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Dissertations / Theses on the topic 'Glycosidases – Inhibitors – Synthesis'

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Published: 4 June 2021

Last updated: 19 February 2022

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1

Caron, Gaétan. "Synthesis of cyclitol-based glucosidase inhibitors." Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/27852.

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The first conduritol aziridine (1,2-dideoxy-1,2-epimino-myo-inositol, 1) was synthesized in seven steps from myo-inositol (2) and inhibits pABG5 β-glucosidase and yeast ⍺-glucosidase irreversibly. 1,2-0-Cyclohexylidene-myo-inositol (3) was obtained by reaction of 2 with cyclohexanone. Benzylation of 3 followed by hydrolysis of the ketal gave l,4,5,6-tetra-0-benzyl-myo-inositol (5). The two free hydroxyl groups in 5 were methanesulfonylated and the axial mesyl group in l,4,5,6-tetra-0-benzyl-2,3-di-0-methanesulfonyl-myo-inositol (12) was selectively displaced by an azido group. The resulting 1-

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2

Meloncelli, Peter J. "The synthesis of several azasugars, glycosylated azasugars and disaccharides of biological interest." University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2007. http://theses.library.uwa.edu.au/adt-WU2007.0052.

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[Truncated abstract] The development of several carbohydrate-based pharmaceuticals has stimulated an increased interest in the field of carbohydrate chemistry. The discovery of Acarbose and invention of Miglitol, treatments for type II diabetes, as well as the influenza treatments, Relenza and Tamiflu, have been largely responsible for this increased interest. These treatments operate by the inhibition of glycoside hydrolases, a group of enzymes important in a variety of biological processes. This thesis involves the study of a group of glycoside hydrolase inhibitors known as azasugars, which

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3

Miglioli, Francesca. "Synthesis and biological evaluation of bicyclic iminosugar derivatives as inhibitors of glycosidases." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amslaurea.unibo.it/16676/.

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During this work, five pyrrolizidine derivatives and one isoxazolidine derivative have been synthetized in order to evaluate their biological activities towards glycosidases, related to their configurations and type of bridge functionalities between the bicyclic iminosugar moiety and the aromatic part of the molecules. The final pyrrolizidine derivatives have been synthetized through click reactions (urea forming reaction, thiourea forming reaction and CuAAC reaction) performed on a common amino-pyrrolizidine precursor. The final isoxazolidine derivative has been synthetized through a CuAAC re

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4

Scaffidi, Adrian. "Synthetic endeavours in carbohydrates." University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2007. http://theses.library.uwa.edu.au/adt-WU2007.0114.

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The overwhelming occurrence and structural diversity of carbohydrates in Nature indicate their importance in a range of fundamental life processes. Indeed, it is this diversity that has lead to the two equally diverse groups of carbohydrate-processing enzymes, namely the glycoside hydrolases and glycosyl transferases. Thus, understanding the role of both carbohydrates and their processing enzymes in biological systems has attracted significant attention. This thesis, firstly, describes endeavours towards the synthesis of an inositol ?- amino acid, along with a series of sugar α-substituted car

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5

Heightman, Tom Daniel. "O-glycosidases under scrutiny: synthesis of inhibitors and structural probes : and Synthesis of a potential DNA-binding pseudotetrasaccharide /." Zürich, 1998. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=12696.

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6

Carpenter, Neil M. "Studies on glycosidase inhibitors." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236101.

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7

Namgoong, Sung Keon. "The synthesis of glycosidase inhibitors." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236199.

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8

Ong, Quyen Binh. "An enantioselective synthesis of glycosidase inhibitors." Thesis, King's College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314209.

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9

Dedola, Simone. "'Click chemistry' to synthesise potential glycosidase inhibitors." Thesis, University of East Anglia, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502211.

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In this study, "click chemistry" was used to assemble a collection of potential glycosidase inhibitors. Using different "click chemistry" conditions, 21 α-D- and β-D glucopyranosyl triazoles were synthesised and assayed as inhibitors of sweet almond β-glucosidase and yeast α-glucosidase. A set of moderately effective glycosidase inhibitors was identified. In the course of this work significant differences in the reactivity of the α- and β-glucopyranosyl azides under CuAAC conditions was noted. This matter was investigated by X-ray crystallography and, in keeping with the anomeric effect, point

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10

Nkansah, Peter Appah. "Syntheses of pyridylglucoconjugates as potential glycosidase inhibitors." Thesis, University of East Anglia, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368182.

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11

Scott, J. Newberry. "The synthesis and evaluation of iminosugars as glycosidase inhibitors." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.543038.

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12

Holt, Karen Elizabeth. "Asymmetric synthesis of aza-sugars using aldolase enzymes." Thesis, University of Cambridge, 1993. https://www.repository.cam.ac.uk/handle/1810/272658.

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13

Ranzinger, Gerlinde. "Studies towards the synthesis of photochromic azasugars as glycosidase inhibitors." Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311741.

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14

Curtis, Kim Louise. "The synthesis of azadisaccharides and aminopyrrolidines as potential glycosidase inhibitors." Thesis, University of Leicester, 2005. http://hdl.handle.net/2381/30094.

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Azadisaccharides e.g. 399 (Figure 1) are known to be potent selective inhibitors of glycosidases and thus have potential as anti-viral, anti-cancer and anti-diabetic agents. We have developed new, efficient, versatile and stereoselective routes to azadisaccharides using non-carbohydrate starting materials. Pinacol methodology has been successfully used to synthesise two (2â†’6) linked homoaza-O-disaccharides mimics and due to the versatility of the synthetic route, modification has enabled the synthesis of a (2â†’6) linked homoaza-O-trisaccharide. Complementary to this, RCM (Grubbs catalyst) a

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15

Glawar, Andreas Felix Gregor. "Design, synthesis and biological evaluation of glycosidase inhibitors in an anti-cancer setting." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:602edf26-d9ff-4fcf-8dec-c8548f3578da.

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The aim of the work described in this thesis was to explore the synthesis of glycosidase inhibitors and to evaluate their potential as anti-cancer agents. Glycosidases catalyze the fission of glycosidic bonds and are involved in vital biological functions. With regard to their potential for anti-cancer therapy, two glycosidases were identified: α-N-acetyl-galactosaminidase and β-N-acetyl-hexosaminidase. The former has been implicated in causing immunosuppression in advanced cancer patients by negating the effect of the macrophage activating factor (MAF), while the latter is secreted by invadin

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16

Neuss, Judi. "Fragmentation-cyclisation approaches to the synthesis of aza-sugars." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338541.

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17

Tanaka, Kelly Sean Eichi. "Synthesis and evaluation of novel conformationally biased and carbocyclic based glycosidase inhibitors." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0025/NQ51926.pdf.

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18

Brazdova, Barbora. "Synthesis and studies of carbohydrate mimetics as glycosidase inhibitors and molecular switches." Scholarly Commons, 2006. https://scholarlycommons.pacific.edu/uop_etds/2651.

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Part I . We explored the synthesis of a C -glycoside synthesis from L-fucose and malononitrile in the presence of a base catalyst. The reaction was much faster than the previously studied Henry condensation, and went further---to a double cyclization of 2:1 adduct with a novel dioxabicyclic structure. It provides a new route for the synthesis of chiral polysubstituted dihydropyrans and dihydropurans. A series of carbasugars was synthesized and tested for inhibitory activity towards fungal glycosidases from Aspergillus oryzae and Penicillium canescens . In order to reveal the dependence of inhi

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19

Maxwell, Vanessa L. "Studies on ring closure heterometathesis and the synthesis of novel glycosidase inhibitors." Thesis, University of Leicester, 2005. http://hdl.handle.net/2381/29972.

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Compound I was synthesised to study intramolecular ring closing metathesis of an oxime and an olefin. In the event an intermolecular reaction took place to give II. (Fig. 11160A).;A series of bias imines IV were synthesised and also subjected to ring closure metathesis conditions using the Grubbs catalyst. No cyclisation was observed. (Fig. 11160B).;Three diamino sugar derivatives V were prepared by epoxide opening of the corresponding 2,3 manno (up) epoxide. Benzylidene deprotection was not possible. (Fig. 11160C).;A further six examples of deprotected diamino altro derivatives 395b-g were pr

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20

Heck, Marie-Pierre. "Synthese d'amidines d'interet therapeutique inhibiteurs potentiels de glycosidases a visee anti vih." Strasbourg 1, 1994. http://www.theses.fr/1994STR15033.

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21

Chevrier, Carine. "Synthèse et évaluation d'aminosucres, inhibiteurs de fucosidases : structure de base pour la conception d'inhibiteurs de fucosyltransférases." Mulhouse, 2003. https://www.learning-center.uha.fr/opac/resource/synthese-et-evaluation-daminosucres-inhibiteurs-de-fucosidases-structure-de-base-pour-la-conception-/BUS3681656.

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L'objectif de ce travail a été de synthétiser des analogues stables du GDP-béta-L-fucose en tant qu'inhibiteurs de fucosyltransférases (agents anti-inflammatoires potentiels). Nous avons, dans un premier temps, synthétisé des analogues de fucose de type aminosucre qui ont été évalués sur l'alpha-L-fucosidase. Dans la série la plus active, nous avons développé une nouvelle voie de synthèse d'un puissant inhibiteur de fucosidase, donnant accès à une structure de base facilement fonctionnalisable : la nitrone en série L-lyxose synthètisée à partir du D-ribose. Des groupes chélatants, acides hydro

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22

Concia, Alda Lisa. "Chemoenzymatic synthesis of sugar-related polyhydroxylated compounds, iminocyclitols and their derivatives as glycosidase inhibitors." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/113239.

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Section 1 (Introduction) is a comprehensive review of the subjects discussed in this thesis: biocatalysis, aldolases and iminocyclitols. It contains a description of the application of dihydroxyacetone phosphate (DHAP) and dihydroxyacetone (DHA) utilizing aldolases to the chemoenzymatic synthesis of bioactive compounds and an introduction to the structure, biological activities and synthesis of iminocyclitols. Recent bibliographic references are included at the end of the section. Section 2 (Objectives) outlines the aims of this thesis. Section 3 (Results and discussion) describes the stud

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23

Camps, Bres Flora. "Synthèse d'aminocyclitols, inhibiteurs potentiels de glycosidases lysosomales, via des aldolases." Phd thesis, Université Blaise Pascal - Clermont-Ferrand II, 2010. http://tel.archives-ouvertes.fr/tel-00629666.

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Les glycosidases sont des enzymes impliquées dans de nombreux processus biologiques. Entre autres, elles sont responsables de la dégradation des déchets polysaccharidiques de nos cellules. Lorsqu'une modification génétique touche un gène qui code pour une de ces enzymes, des pathologies graves regroupées sous l'appellation de " maladies lysosomales " peuvent être déclenchées. L'objectif de ce projet a été de proposer une méthode de synthèse efficace de molécules potentiellement actives spécifiquement sur l'une ou l'autre de ces maladies. Les molécules ciblées sont des inhibiteurs de glycosidas

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24

Best, Daniel. "Rare monosaccharides and biologically active iminosugars from carbohydrate chirons." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:028392ce-6580-4fb9-bdc3-9be702b951e4.

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Iminosugars are polyhydroxylated alkaloids, and can be viewed as sugar analogues in which the endocyclic oxygen atom has been replaced with nitrogen. These compounds are highly medically relevant and their biological activity is largely due to their inhibition of glycosidases. Several examples of the iminosugar class are currently marketed as drugs, and many more are in earlier stages of development for a variety of diseases and disorders. The most fruitful approaches to the chemical synthesis of iminosugars have utilised carbohydrate starting materials as optically pure chiral building blocks

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25

Fraser, Rebecca Dawn. "Isolation of natural product inhibitors and synthesis of inhibitors of signal transduction : Part II structure-activity relationship for a series of glycosidase inhibitors." Diss., Georgia Institute of Technology, 1993. http://hdl.handle.net/1853/30508.

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26

Zelli, Renaud. "Synthèse sans catalyseurs métalliques de systèmes multivalents à base d'iminosucres, nouveaux inhibiteurs de glycosidases." Thesis, Montpellier, Ecole nationale supérieure de chimie, 2015. http://www.theses.fr/2015ENCM0015.

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Les iminosucres sont des composés azotés polyhydroxylés mono- (pyrrolidine, piperidine, azepane) ou bicycliques (pyrrolizidine, indolizidine, nortropane) démontrant une forte activité inhibitrice envers les glycosidases, enzymes catalysant l'hydrolyse des liaisons glycosidiques des glycoconjugués. Le développement de nouveaux dérivés d'iminosucres est essentiel afin d'obtenir de nouveaux traitements contre des maladies comme le diabète de type II, la mucoviscidose ou les troubles du stockage lysosomale (maladies de Gaucher ou de Fabry par exemple). Des études récentes ont démontré que l'utilis

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27

Razavi, Hossein. "Amino acid Schiff base methodology for the synthesis of glycosidase inhibitors: Polyhydroxylated pyrrolidines and indolizidines." Diss., The University of Arizona, 1999. http://hdl.handle.net/10150/284049.

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The concise enantioselective syntheses of iminolyxitol and iminoribitol glycosidase inhibitors starting from benzophenone imines, of D-serine and L-alanine esters are presented. The reductive alkenylation of the Schiff bases followed by substrate-directed dihydroxylation and cyclization under various amino dehydration conditions (Ph₃P, CCl₄, or TEMPO oxidation/NaCNBH₃ reduction) gave the polyhydroxylated pyrrolidines in excellent overall yields (23% for 1 → 8a, 12% for 1 → 8b, 13% for 11 → 18a). In addition, synthesis of indolizidine glycosidase inhibitor 8- epi-swainsonine has been achieved.

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28

MONTHILLER, SOPHIE. "Synthese de 9-oxa-quinolizidines, inhibiteurs potentiels de glycosidases a visee anti-vih." Université Louis Pasteur (Strasbourg) (1971-2008), 1994. http://www.theses.fr/1994STR13138.

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Ce travail traite de la synthese et de l'evaluation biologique de 9-oxaquinolizidines, inhibiteurs potentiels de glycosidases a visee anti-sida. La conception de ces nouveaux inhibiteurs de glycosidases possedant une fonction perhydro-oxazine, a ete realisee en se basant sur le mecanisme d'hydrolyse des glycosides. Le principe des syntheses repose sur l'utilisation d'hexopyranoses comme produit de depart, de meme stereochimie que les composes souhaites. Cette derniere a ete conservee via des reactions d'amination reductrice stereoselectives. Les reactivites observees en serie glucose, mannose

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Lenagh-Snow, Gabriel Matthew Jack. "The synthesis of azetidine and piperidine iminosugars from monosaccharides." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:207235d5-2ea5-4724-92fd-924fa0ccd4ed.

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Iminosugars are polyhydroxylated alkaloids, and can be generally defined as sugar mimetics in which the endocyclic oxygen atom has been replaced with a basic nitrogen. A common affect of this atomic substitution is to bestow these compounds with the ability to inhibit various sugarprocessing enzymes; most significantly the glycosidases (glycoside hydrolases) which areintimately involved in a huge array of biological functions. Compounds which inhibit these enzymes concordantly possess much potential as medicinal agents for the treatment of a variety of diseases. Several iminosugars have alread

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30

Ramstadius, Clinton. "Synthesis of Carbohydrate Mimics and Development of a Carbohydrate Epimerisation Method." Doctoral thesis, Stockholms universitet, Institutionen för organisk kemi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-45855.

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In this thesis the synthesis of several hydrolytically stable carbohydrate mimics with the potential to function as glycosidase or lectin inhibitors are described. This work is presented in Chapters 2-5. Chapters 2 and 3 describe synthetic efforts for producing carbasugars, and include the first synthesis of 1,2-bis-epi-valienamine and the preparation of two previously known aminocarbasugars. All three compounds were synthesised starting from D-mannose, using ring-closing metathesis as the key step. 1,2-Bis-epi-valienamine was found to inhibit Cellulomonas fimi β-mannosidase with a Ki value of

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31

Roth, Alexander J. K. [Verfasser], and Christian B. W. [Akademischer Betreuer] Stark. "Untersuchungen zur Aldehyd-Hydrat-Stabilisierung durch N-Oxide sowie Synthese und Untersuchung von Morpholinderivaten als Glycosidase-Inhibitoren / Alexander J. K. Roth. Betreuer: Christian B. W. Stark." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2014. http://d-nb.info/1057002046/34.

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32

Wu, Pey Jiuann, and 吳佩絹. "Synthesis of glycosidase inhibitors." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/91565010674613604602.

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碩士<br>國立彰化師範大學<br>化學系<br>96<br>We successfully synthesized a series of aza-C-glycoside derivatives, N-alkylated aza-C-glycosides and aza-C-disaccharides starting from the commercial D-ribose. Our strategy takes advantage of a direct coupling reaction of alkylated amine with 5-OMs-ribose and further underwent intramolecular hetero-Michael reaction under base condition. In addition, we also prepared a series of ether bridge bicyclo azasugar 58 and N-alkyl ether bridge bicyclo azasugar derivatives 60 starting from 38. When further deprotected, they may therefore provide access to a large number o

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GUO, Chao-Ci, and 郭朝其. "The Synthesis of glycosidase inhibitors and fluorescent chemosensors derivatives." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/58171484089769612463.

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碩士<br>國立彰化師範大學<br>化學系<br>96<br>We synthesized a series of N-alkylated aza-C-glycosides starting from the commercial D-ribose. Our strategy take advantage of a direct coupling reaction of alkylated amine with 5-OMs-ribose and further undergoes intramolecular hetero-Michael reaction under base condition. In addition, we also synthesized a novel cyclodextrin-like artifical receptor which is a 1,2,3-triazole compound through Huisgen 1,3-dipolar cycloadditions of alkynes to azides. This idea is based upon the assumption that a cyclic array of carbohydrate moieties, nitrogen atom and amino acid func

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34

Li, Heng-Yi, and 李恆毅. "Synthesis of aminocyclitols(deoxyinosamines) and polyhydroxyindolizidines for potential glycosidase inhibitors." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/67744090257103290862.

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碩士<br>淡江大學<br>化學學系碩士班<br>95<br>Naturally occurring polyhydroxylated aminosugars are considered to be potential glycosidase inhibitors. These glycosidase inhibitors possess potential in the treatment of cancers, HIV, diabetes and metabolic disorders. Especially in diabetes, it is estimated that the number of diabetes patients is expectd to rise from the current estimated of 150 million to 220 million in 2010. Polyhydroxylated aminosugars have been known as glycosidase inhibitors. They display the same stereochemistry as the corresponding hexoses, exceptor nitrogen atom replacing the original o

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35

林昌慶. "Synthesis of α(2→9) Oligosialic Acids and Glycosidase Inhibitors". Thesis, 2005. http://ndltd.ncl.edu.tw/handle/45587978576346815030.

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博士<br>國立清華大學<br>化學系<br>94<br>Chapter 1: Synthesis of ��(2→9) Oligosialic Acids In the first part of this chapter, we accomplished new phosphite-based donors for efficient and highly ��-selective synthesis of oligosialic acids (up to pentasialoside) using iterative sialylation. Although the ��-selectivity decreased with increasing size of the donor, pure pentasialic acid was obtained on the 10 mg scale. We believe that these phosphite donors will have applications in the development of polysialic acid based vaccines. In the second part, we focussed on the large-scale synthesis of per-O-acetyl

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"Studies on synthetic and naturally occurring glycosidase inhibitors from mushrooms." Chinese University of Hong Kong, 1994. http://library.cuhk.edu.hk/record=b5887198.

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Fung Pik Ha.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 1994.<br>Includes bibliographical references (leaves 116-121).<br>Acknowledgments --- p.i<br>Table of Contents --- p.ii<br>List of Figures --- p.v<br>List of Tables --- p.x<br>Abstract --- p.xi<br>Chapter Chapter I --- Introduction --- p.1<br>Chapter Chapter II --- Literature Reviews<br>Chapter II.l --- Glycosidase --- p.3<br>Chapter II.2 --- Biosynthesis of N-linked Glycoprotein --- p.4<br>Chapter II.3 --- Mechanism of Enzyme Catalysed Reaction --- p.8<br>Chapter II.4 --- Types of Glycosidase Inhibitors --- p.12<br>C

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Chiang, Cheng-Fang, and 蔣呈凡. "Synthesis of 7-Hydroxymethyl-3,4,5-trihydroxyazepanes and Polyhydroxyperhydroazaazulenes for glycosidase inhibitors." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/76374430387067480094.

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碩士<br>淡江大學<br>化學學系碩士班<br>95<br>Azasugars are considered as glycosidase inhibitors and possess potential in treatment of diabetes, cancers, and AIDS. Seven-membered azasugars were reported to be more conformationally flexible than the corresponding six- and five-membered counterparts, but little attention has been paid. We describe herein a new approach to the synthesis of diastereomeric 7-hydroxymethyl-3,4,5-trihydroxyazepanes in ten steps from D-(-)-quinic acid. We also compare the biological activities with C2-symmetrical tetrahydroxy -azepanes. In addition, 5,7-heterocyclic ring sys

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38

張元軍. "Synthesis of N-alkyl Iminoalditol and pyrrolidine derivatives as Glycosidase Inhibitors." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/83759606820380930634.

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碩士<br>國立彰化師範大學<br>化學系<br>97<br>The goals of our research are to synthesize glycosidase inhibitors. The first project is using D-ribose as starting material to synthesize the derivatives of ribopyranoside. We are successful to obtain the target compound methyl 2-C-(5-deoxy-2,3-di-O-isopropylidene-5 morpholinopropylamino-β-D-ribopyranosyl) acetate 7, methyl 2-C-(5-deoxy-2,3-di-O-isopropylidene-5-decylamino-β-Dribopyranosyl) acetate 9, 2-C-(5-deoxy-2,3-di-O-isopropylidene-5-morpholinopropyl amino-β-D-ribopyranosyl)ethanol 8, and 2-C-(5-deoxy-2,3-di-O-isopropylidene-5- decylamino -β-D-ribopyranosy

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Liang, Ming-Tsung, and 梁名琮. "Synthesis of Polyhydorxylated 7-Alkylazepanes as Potent Glycosidase Inhibitors from D-(—)-Quinic acid." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/55451187134500140402.

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碩士<br>淡江大學<br>化學學系碩士班<br>96<br>The biological activities of polyhydroxylated piperidines and their derivatives have been extensively studied during the past decades. These molecules are potentially therapeutic agents, especially, to serve as glycosidase inhibitors in treatment of cancers, diabetes and viral infections. The C- and N-alkylated piperidines are competitive glycosidase inhibitors to their corresponding molecules. Among them, deoxyfuconojirimycin (1,5-deoxy-1,5-imino-L-fucitol) was inhibitor against

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Kuo, Wei-Shen, and 郭威伸. "Synthesis of a New Trihydroxy Piperidine Derivative for Glycosidase Inhibitor from D-(-)-Quinic Acid." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/86579139954835053864.

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碩士<br>淡江大學<br>化學學系<br>92<br>Recently, the syntheses of glycosidase inhibitors have attracted a great deal of attention in academies and industries. These glycosidase inhibitors possess potential in the treatment of cancers, HIV, diabetes and metabolic disorders.The polyhydroxylated piperidines (called “azasugars” or “iminosugars”) have been known as glycosidase inhibitors. They display the same stereochemical information as common hexoses, but a nitrogen atom replaced the ring oxygen of the corresponding pyranose. Among these azasugars, the representative morecu1es, such as 1-deoxynojirimycin

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Gunasundari, T. "Design, Synthesis and Applications of Novel Thiosugars & Amino Acid Derivatives." Thesis, 2012. http://hdl.handle.net/2005/3225.

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Abstract:

Glycosidases are carbohydrate processing essential enzymes necessary for the growth and development of all organisms such as intestinal digestion, post-translational processing of glycoproteins and the lysosomal catabolism of glycoconjugates. The function of these glycosidases is limited and studies are still in progress to understand their function at cellular level. In recent years, biological role of carbohydrates has resulted in various carbohydrate-based therapeutics2. These carbohydrates serve as a tool to study the function of glycosidases by inhibiting their active site. The concept of

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