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Relevant bibliographies by topics / HBND2

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Academic literature on the topic 'HBND2'

Author: Grafiati

Published: 26 July 2024

Last updated: 31 July 2025

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Journal articles on the topic "HBND2"

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Štrajtenberger, Maja, Liborija Lugović-Mihić, Asja Stipić-Marković, et al. "Assesment of Salivary and Serum Levels of HBD2 in Patients with Chronic Angioedema." Journal of Clinical Medicine 13, no. 24 (2024): 7552. https://doi.org/10.3390/jcm13247552.

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Background/Objectives: Human β-defensin 2 (HBD2) is a protein that plays an important role in activating the immune system by modulating spinal pathways and the inflammatory response. According to previous research, HBD2 was proven to be important in chronic spontaneous urticaria (CSU) (their values were significantly elevated in CSU patients, with a significant correlation between HBD2 levels and the percentage of peripheral basophils, suggesting that elevated HBD2 levels may be a potential marker of basophil and mast cell activation), which led us to additional research on the HBD2 molecule

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Beadell, Brent A., Andy Chieng, Kevin R. Parducho, et al. "Nano- and Macroscale Imaging of Cholesterol Linoleate and Human Beta Defensin 2-Induced Changes in Pseudomonas aeruginosa Biofilms." Antibiotics 10, no. 11 (2021): 1279. http://dx.doi.org/10.3390/antibiotics10111279.

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The biofilm production of Pseudomonas aeruginosa (PA) is central to establishing chronic infection in the airways in cystic fibrosis. Epithelial cells secrete an array of innate immune factors, including antimicrobial proteins and lipids, such as human beta defensin 2 (HBD2) and cholesteryl lineolate (CL), respectively, to combat colonization by pathogens. We have recently shown that HBD2 inhibits biofilm production by PA, possibly linked to interference with the transport of biofilm precursors. Considering that both HBD2 and CL are increased in airway fluids during infection, we hypothesized

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Xi, Gang, Melissa A. Solum, Christine Wai, Laura A. Maile, Clifford J. Rosen, and David R. Clemmons. "The Heparin-Binding Domains of IGFBP-2 Mediate Its Inhibitory Effect on Preadipocyte Differentiation and Fat Development in Male Mice." Endocrinology 154, no. 11 (2013): 4146–57. http://dx.doi.org/10.1210/en.2013-1236.

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IGF-binding protein (IGFBP)-2 overexpression confers resistance to high-fat feeding and inhibits the differentiation of preadipocytes in vitro. However, whether administration of IGFBP-2 can regulate adipogenesis in vivo and the domains that mediate this response have not been defined. IGFBP-2 contains 2 heparin-binding domains (HBD), which are localized in the linker region (HBD1) and C-terminal region (HBD2) of IGFBP-2. To determine the relative importance of these domains, we used synthetic peptides as well as mutagenesis. Both HBD1 and HBD2 peptides inhibited preadipocyte differentiation,

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Routsias, John G., Dionysia Marinou, Maria Mavrouli, Athanasios Tsakris та Vassiliki Pitiriga. "Serum β-Defensin 2, A Novel Biomarker for the Diagnosis of Acute Infections". Diagnostics 13, № 11 (2023): 1885. http://dx.doi.org/10.3390/diagnostics13111885.

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Background: Defensins are natural antimicrobial peptides that the human body secretes to protect itself from an infection. Thus, they are ideal molecules to serve as biomarkers for infection. This study was conducted to evaluate the levels of human β-defensins in patients with inflammation. Methods: CRP, hBD2 and procalcitonin were measured in 423 sera of 114 patients with inflammation and healthy individuals using nephelometry and commercial ELISA assays. Results: Levels of hBD2 in the serum of patients with an infection were markedly elevated compared to those of hBD2 in patients with inflam

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Hosny, Alaa El-Dien Shawky, Mohammed Abdelhalim Ramadan, Maha Ahmed Shafik, Mahmoud Ahmed Shafeek, and Rania Abdelmonem Khattab. "Expression levels of pro-inflammatory interleukin-8 and certain antimicrobial peptides in concurrent with bacterial conjunctivitis." International Journal of Ophthalmology 14, no. 5 (2021): 666–75. http://dx.doi.org/10.18240/ijo.2021.05.05.

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AIM: To detect the quantitative expression levels of the pro-inflammatory interleukin-8 (IL8), antimicrobial peptides human beta defense-2 (HBD2), and human beta defense-3 (HBD3) genes in bacterial conjunctivitis. METHODS: The human conjunctival epithelial cells were obtained using the impression cytology technique from healthy controls and patients. The genes expression levels were determined utilizing a reverse transcription quantitative polymerase chain reaction (RT-qPCR). The contribution of causative agent type, the number of isolates and severity of clinical features, in the increase of

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Yin, Lei, та Beverly A. Dale. "Activation of protective responses in oral epithelial cells by Fusobacterium nucleatum and human β-defensin-2". Journal of Medical Microbiology 56, № 7 (2007): 976–87. http://dx.doi.org/10.1099/jmm.0.47198-0.

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Oral epithelia are constantly exposed to non-pathogenic (commensal) bacteria, but generally remain healthy and uninflamed. Fusobacterium nucleatum, an oral commensal bacterium, strongly induces human β-defensin-2 (hBD2), an antimicrobial and immunomodulatory peptide, in gingival epithelial cells (GECs). hBD2 is also expressed in normal oral tissue leading to the hypothesis that oral epithelia are in an activated state with respect to innate immune responses under normal in vivo conditions. In order to test this hypothesis, global gene expression was evaluated in GECs in response to stimulation

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Harris, Peggy, Amber Kerstetter-Fogle, Anthony Sloan, et al. "STEM-20. THE ROLE OF HUMAN BETA DEFENSINS IN THE CLONOGENICITY OF GLIOBLASTOMA MULTIFORME." Neuro-Oncology 23, Supplement_6 (2021): vi25. http://dx.doi.org/10.1093/neuonc/noab196.094.

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Abstract INTRODUCTION Glioblastoma (GBM) is the most common primary malignant brain tumor with a median overall survival of 12-15months. GBM aggressiveness and poor response to treatment are often attributed to a small population of stem-like cells referred to as glioma stem cells (GSCs). Human Beta-Defensins (HBDs), a family of small molecules initially thought to function as anti-microbials, have been implicated in various cancers with functions that are cancer type specific, including proinflammatory and immunosuppressive roles. GOAL: This study aimed to elucidate HBDs expression in GSCs an

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Ouhara, Kazuhisa, Hitoshi Komatsuzawa, Hideki Shiba та ін. "Actinobacillus actinomycetemcomitans Outer Membrane Protein 100 Triggers Innate Immunity and Production of β-Defensin and the 18-Kilodalton Cationic Antimicrobial Protein through the Fibronectin-Integrin Pathway in Human Gingival Epithelial Cells". Infection and Immunity 74, № 9 (2006): 5211–20. http://dx.doi.org/10.1128/iai.00056-06.

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ABSTRACT Antimicrobial peptides, human β-defensin (hBD), and the 18-kDa cationic antimicrobial protein (CAP18) are components of innate immunity. These peptides have antimicrobial activity against bacteria, fungi, and viruses. Actinobacillus actinomycetemcomitans is a gram-negative facultative anaerobe implicated in the initiation of periodontitis. The innate immunity peptides have antibacterial activity against A. actinomycetemcomitans. We investigated the molecular mechanism of human gingival epithelial cells (HGEC) responding to exposure to A. actinomycetemcomitans. HGEC constitutively expr

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Antcheva, Nikolinka, Michele Boniotto, Igor Zelezetsky та ін. "Effects of Positively Selected Sequence Variations in Human and Macaca fascicularis β-Defensins 2 on Antimicrobial Activity". Antimicrobial Agents and Chemotherapy 48, № 2 (2004): 685–88. http://dx.doi.org/10.1128/aac.48.2.685-688.2004.

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ABSTRACT The evolution of orthologous genes coding for β-defensin 2 (BD2) in primates has been subject to positive selection during the divergence of the platyrrhines from the catarrhines and of the Cercopithecidae from the Hylobatidae, great apes, and humans. Three peptides have been selected for a functional analysis of the effects of sequence variations on the direct antimicrobial activity: human BD2 (hBD2), Macaca fascicularis BD2 (mfaBD2), and a variant of the human peptide lacking Asp4, (−D)hBD2, which is characteristic only of the human/great ape peptides. hBD2 and mfaBD2 showed a signi

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Sun, Lingling, Catherine M. Finnegan, Tina Kish-Catalone та ін. "Human β-Defensins Suppress Human Immunodeficiency Virus Infection: Potential Role in Mucosal Protection". Journal of Virology 79, № 22 (2005): 14318–29. http://dx.doi.org/10.1128/jvi.79.22.14318-14329.2005.

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ABSTRACT β-Defensins are small (3 to 5 kDa in size) secreted antimicrobial and antiviral proteins that are components of innate immunity. β-Defensins are secreted by epithelial cells, and they are expressed at high levels in several mucosae, including the mouth, where the concentration of these proteins can reach 100 μg/ml. Because of these properties, we wondered whether they could be part of the defenses that lower oral transmission of human immunodeficiency virus (HIV) compared to other mucosal sites. Our data show that select β-defensins, especially human β-defensin 2 (hBD2) and hBD3, inhi

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Dissertations / Theses on the topic "HBND2"

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Yovcheva, Venelina Zlateva [Verfasser], Thomas [Akademischer Betreuer] Hehlgans, and Wulf [Akademischer Betreuer] Schneider. "Die Rolle von hBD2 und hBD3 im entzündlichen und malignen Kontext / Venelina Zlateva Yovcheva. Betreuer: Thomas Hehlgans ; Wulf Schneider." Regensburg : Universitätsbibliothek Regensburg, 2013. http://d-nb.info/1037021355/34.

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Vargues, Thomas. "Antimicrobial peptides : structure, function and resistance." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4076.

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Higher eukaryotes produce a vast range of antimicrobial peptides (AMPs) that play important roles in their defence against microbial infection. Beta defensins are small (3-5 kDa), cationic peptides that display broad, potent antimicrobial activity against a range of microbes and also act as chemoattractants of important immunomodulatory cells. To generate highly pure peptides for structural and functional studies, we developed a method to prepare recombinant human beta defensin-2 (HBD2). The HBD2 gene was synthesised by recursive PCR with codons optimised for expression in Escherichia coli. HB

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Capewell, Samantha Jessica. "Structural and functional studies of protein targets at the host-pathogen interface." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/9636.

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Ferric ABC Transporters. Pathogenic bacteria have evolved specialised iron acquisition systems that allow them to effectively colonise a host. One of these systems is the ferric binding protein (Fbp) complex that is a member of the ATP-Binding Cassette (ABC) superfamily of small molecule transporters. The Fbp complex is made up of three-components (FbpABC) that transports ferric iron from the periplasm to the cytoplasm of many Gram negative bacteria. FbpA binds iron in the periplasm and transports it to the FbpB transporter complex that permeates the cytoplasmic membrane. Here the iron is acti

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Wang, Bingjie. "Novel function of human beta-defensin 2 : protecting epidermal barrier against pathogenic proteases." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28756.

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Atopic Dermatitis (AD) is a common chronic relapsing inflammatory skin disease affecting 15 - 20% of children and 2 - 10% of adults worldwide, with significant morbidity. A hallmark of AD is disruption of the critical barrier function of upper epidermal layers, causatively linked to environmental stimuli, genetics and infections. Another typical feature of AD is skin infections, especially from Staphylococcus aureus (S. aureus), which closely relates with the disease severity. Although not a normal flora, S. aureus is found on 75-100% of AD lesions (< 30% on healthy skin). S. aureus secrete a

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Creatti, Luisa. "Studi sulle interazioni tra i peptidi di difesa dell' ospite e cellule dell' immunità." Doctoral thesis, Università degli studi di Trieste, 2010. http://hdl.handle.net/10077/3697.

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2008/2009<br>We are exposed daily to a myriad of potential pathogens, mainly through dermal contact, ingestion and inhalation. The innate immune system is of crucial importance in preventing pathogens from colonizing and growing to a point where they can cause life-threatening infections. Different types of cationic antimicrobial peptides (AMP), also known as host defense peptides (HDP), are among the innate immune mechanisms involved in this protective activity. -defensins are an important class of antimicrobial peptides that are present in human beings and have been widely reported to dis

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Huang, Kun-Che, and 黃堃哲. "HBD2-Overexpression decreases BMSC Proinflammatory Cytokine Expression of BMSC after Porphyromonas gingivalis Lipopolysaccharide Stimulation." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/2ghv7x.

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碩士<br>國立陽明大學<br>口腔生物研究所<br>106<br>Periodontitis is a common oral inflammatory disease caused by bacterial infection which leads to destruction of periodontal tissues. Successful periodontal regenerative therapy requires reduction of bacteria-related pathogenic factors and promotion of tissue regeneration. Porphyromonas gingivalis (Pg) is a major pathogen of periodontitis. Pg lipopolysaccharide (LPS) induces the production of proinflammatory cytokines, such as interleukin (IL)-1β (IL-1β), IL-6, and IL-8, and plays an important role in Pg’s pathogenic mechanism. Human β-defensin 2 (hBD2) is an i

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Book chapters on the topic "HBND2"

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Enna, S. J., and David B. Bylund. "HBD2." In xPharm: The Comprehensive Pharmacology Reference. Elsevier, 2007. http://dx.doi.org/10.1016/b978-008055232-3.61878-1.

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Conference papers on the topic "HBND2"

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Armbruster, N., B. Jensen, D. Mailänder-Sánchez, et al. "Rekombinantes orales humanes beta-Defensin 2 (hBD2) verbessert signifikant die experimentell induzierte Colitis in vivo." In Viszeralmedizin 2017. Georg Thieme Verlag KG, 2017. http://dx.doi.org/10.1055/s-0037-1604801.

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Mailänder-Sánchez, D., N. Armbruster, S. Kjaerulf, et al. "Rekombinantes subkutanes humanes beta-Defensin 2 (hBD2) lindert die experimentell induzierte Colitis in verschiedenen Mausmodellen in vivo." In Viszeralmedizin 2017. Georg Thieme Verlag KG, 2017. http://dx.doi.org/10.1055/s-0037-1604800.

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