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Journal articles on the topic 'HBND2'

Author: Grafiati

Published: 26 July 2024

Last updated: 31 July 2025

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1

Štrajtenberger, Maja, Liborija Lugović-Mihić, Asja Stipić-Marković, et al. "Assesment of Salivary and Serum Levels of HBD2 in Patients with Chronic Angioedema." Journal of Clinical Medicine 13, no. 24 (2024): 7552. https://doi.org/10.3390/jcm13247552.

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Background/Objectives: Human β-defensin 2 (HBD2) is a protein that plays an important role in activating the immune system by modulating spinal pathways and the inflammatory response. According to previous research, HBD2 was proven to be important in chronic spontaneous urticaria (CSU) (their values were significantly elevated in CSU patients, with a significant correlation between HBD2 levels and the percentage of peripheral basophils, suggesting that elevated HBD2 levels may be a potential marker of basophil and mast cell activation), which led us to additional research on the HBD2 molecule

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Beadell, Brent A., Andy Chieng, Kevin R. Parducho, et al. "Nano- and Macroscale Imaging of Cholesterol Linoleate and Human Beta Defensin 2-Induced Changes in Pseudomonas aeruginosa Biofilms." Antibiotics 10, no. 11 (2021): 1279. http://dx.doi.org/10.3390/antibiotics10111279.

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The biofilm production of Pseudomonas aeruginosa (PA) is central to establishing chronic infection in the airways in cystic fibrosis. Epithelial cells secrete an array of innate immune factors, including antimicrobial proteins and lipids, such as human beta defensin 2 (HBD2) and cholesteryl lineolate (CL), respectively, to combat colonization by pathogens. We have recently shown that HBD2 inhibits biofilm production by PA, possibly linked to interference with the transport of biofilm precursors. Considering that both HBD2 and CL are increased in airway fluids during infection, we hypothesized

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Xi, Gang, Melissa A. Solum, Christine Wai, Laura A. Maile, Clifford J. Rosen, and David R. Clemmons. "The Heparin-Binding Domains of IGFBP-2 Mediate Its Inhibitory Effect on Preadipocyte Differentiation and Fat Development in Male Mice." Endocrinology 154, no. 11 (2013): 4146–57. http://dx.doi.org/10.1210/en.2013-1236.

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IGF-binding protein (IGFBP)-2 overexpression confers resistance to high-fat feeding and inhibits the differentiation of preadipocytes in vitro. However, whether administration of IGFBP-2 can regulate adipogenesis in vivo and the domains that mediate this response have not been defined. IGFBP-2 contains 2 heparin-binding domains (HBD), which are localized in the linker region (HBD1) and C-terminal region (HBD2) of IGFBP-2. To determine the relative importance of these domains, we used synthetic peptides as well as mutagenesis. Both HBD1 and HBD2 peptides inhibited preadipocyte differentiation,

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Routsias, John G., Dionysia Marinou, Maria Mavrouli, Athanasios Tsakris та Vassiliki Pitiriga. "Serum β-Defensin 2, A Novel Biomarker for the Diagnosis of Acute Infections". Diagnostics 13, № 11 (2023): 1885. http://dx.doi.org/10.3390/diagnostics13111885.

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Background: Defensins are natural antimicrobial peptides that the human body secretes to protect itself from an infection. Thus, they are ideal molecules to serve as biomarkers for infection. This study was conducted to evaluate the levels of human β-defensins in patients with inflammation. Methods: CRP, hBD2 and procalcitonin were measured in 423 sera of 114 patients with inflammation and healthy individuals using nephelometry and commercial ELISA assays. Results: Levels of hBD2 in the serum of patients with an infection were markedly elevated compared to those of hBD2 in patients with inflam

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Hosny, Alaa El-Dien Shawky, Mohammed Abdelhalim Ramadan, Maha Ahmed Shafik, Mahmoud Ahmed Shafeek, and Rania Abdelmonem Khattab. "Expression levels of pro-inflammatory interleukin-8 and certain antimicrobial peptides in concurrent with bacterial conjunctivitis." International Journal of Ophthalmology 14, no. 5 (2021): 666–75. http://dx.doi.org/10.18240/ijo.2021.05.05.

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AIM: To detect the quantitative expression levels of the pro-inflammatory interleukin-8 (IL8), antimicrobial peptides human beta defense-2 (HBD2), and human beta defense-3 (HBD3) genes in bacterial conjunctivitis. METHODS: The human conjunctival epithelial cells were obtained using the impression cytology technique from healthy controls and patients. The genes expression levels were determined utilizing a reverse transcription quantitative polymerase chain reaction (RT-qPCR). The contribution of causative agent type, the number of isolates and severity of clinical features, in the increase of

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Yin, Lei, та Beverly A. Dale. "Activation of protective responses in oral epithelial cells by Fusobacterium nucleatum and human β-defensin-2". Journal of Medical Microbiology 56, № 7 (2007): 976–87. http://dx.doi.org/10.1099/jmm.0.47198-0.

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Oral epithelia are constantly exposed to non-pathogenic (commensal) bacteria, but generally remain healthy and uninflamed. Fusobacterium nucleatum, an oral commensal bacterium, strongly induces human β-defensin-2 (hBD2), an antimicrobial and immunomodulatory peptide, in gingival epithelial cells (GECs). hBD2 is also expressed in normal oral tissue leading to the hypothesis that oral epithelia are in an activated state with respect to innate immune responses under normal in vivo conditions. In order to test this hypothesis, global gene expression was evaluated in GECs in response to stimulation

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Harris, Peggy, Amber Kerstetter-Fogle, Anthony Sloan, et al. "STEM-20. THE ROLE OF HUMAN BETA DEFENSINS IN THE CLONOGENICITY OF GLIOBLASTOMA MULTIFORME." Neuro-Oncology 23, Supplement_6 (2021): vi25. http://dx.doi.org/10.1093/neuonc/noab196.094.

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Abstract INTRODUCTION Glioblastoma (GBM) is the most common primary malignant brain tumor with a median overall survival of 12-15months. GBM aggressiveness and poor response to treatment are often attributed to a small population of stem-like cells referred to as glioma stem cells (GSCs). Human Beta-Defensins (HBDs), a family of small molecules initially thought to function as anti-microbials, have been implicated in various cancers with functions that are cancer type specific, including proinflammatory and immunosuppressive roles. GOAL: This study aimed to elucidate HBDs expression in GSCs an

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Ouhara, Kazuhisa, Hitoshi Komatsuzawa, Hideki Shiba та ін. "Actinobacillus actinomycetemcomitans Outer Membrane Protein 100 Triggers Innate Immunity and Production of β-Defensin and the 18-Kilodalton Cationic Antimicrobial Protein through the Fibronectin-Integrin Pathway in Human Gingival Epithelial Cells". Infection and Immunity 74, № 9 (2006): 5211–20. http://dx.doi.org/10.1128/iai.00056-06.

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ABSTRACT Antimicrobial peptides, human β-defensin (hBD), and the 18-kDa cationic antimicrobial protein (CAP18) are components of innate immunity. These peptides have antimicrobial activity against bacteria, fungi, and viruses. Actinobacillus actinomycetemcomitans is a gram-negative facultative anaerobe implicated in the initiation of periodontitis. The innate immunity peptides have antibacterial activity against A. actinomycetemcomitans. We investigated the molecular mechanism of human gingival epithelial cells (HGEC) responding to exposure to A. actinomycetemcomitans. HGEC constitutively expr

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Antcheva, Nikolinka, Michele Boniotto, Igor Zelezetsky та ін. "Effects of Positively Selected Sequence Variations in Human and Macaca fascicularis β-Defensins 2 on Antimicrobial Activity". Antimicrobial Agents and Chemotherapy 48, № 2 (2004): 685–88. http://dx.doi.org/10.1128/aac.48.2.685-688.2004.

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ABSTRACT The evolution of orthologous genes coding for β-defensin 2 (BD2) in primates has been subject to positive selection during the divergence of the platyrrhines from the catarrhines and of the Cercopithecidae from the Hylobatidae, great apes, and humans. Three peptides have been selected for a functional analysis of the effects of sequence variations on the direct antimicrobial activity: human BD2 (hBD2), Macaca fascicularis BD2 (mfaBD2), and a variant of the human peptide lacking Asp4, (−D)hBD2, which is characteristic only of the human/great ape peptides. hBD2 and mfaBD2 showed a signi

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Sun, Lingling, Catherine M. Finnegan, Tina Kish-Catalone та ін. "Human β-Defensins Suppress Human Immunodeficiency Virus Infection: Potential Role in Mucosal Protection". Journal of Virology 79, № 22 (2005): 14318–29. http://dx.doi.org/10.1128/jvi.79.22.14318-14329.2005.

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ABSTRACT β-Defensins are small (3 to 5 kDa in size) secreted antimicrobial and antiviral proteins that are components of innate immunity. β-Defensins are secreted by epithelial cells, and they are expressed at high levels in several mucosae, including the mouth, where the concentration of these proteins can reach 100 μg/ml. Because of these properties, we wondered whether they could be part of the defenses that lower oral transmission of human immunodeficiency virus (HIV) compared to other mucosal sites. Our data show that select β-defensins, especially human β-defensin 2 (hBD2) and hBD3, inhi

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Zaynullina, O. N., D. V. Pechkurov, Z. R. Khismatullina, and K. R. Mirkhaidarova. "Human beta-defensin 2, secretory immunoglobulin A, and lysozyme in different specimens of children with atopic dermatitis." Voprosy praktičeskoj pediatrii 16, no. 6 (2021): 45–51. http://dx.doi.org/10.20953/1817-7646-2021-6-45-51.

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Objective. To evaluate the levels of human beta-defensin 2 (HBD2), secretory immunoglobulin A (sIgA), and lysozyme in various biological specimens from children with atopic dermatitis and to assess their correlation with the severity of clinical manifestations. Patients and methods. This study included 96 children with atopic dermatitis and 31 healthy controls. We measured serum HBD2, salivary and fecal sIgA, and salivary and fecal lysozyme using special ELISA Kits (CUSABIO, Korea). Results. In children with atopic dermatitis, median levels of serum HBD2 (544 pg/mL [range: 288; 719]), salivary

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LEITCH, G. J., and C. CEBALLOS. "A role for antimicrobial peptides in intestinal microsporidiosis." Parasitology 136, no. 2 (2008): 175–81. http://dx.doi.org/10.1017/s0031182008005313.

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SUMMARYClinical isolates from 3 microsporidia species,Encephalitozoon intestinalisandEncephalitozoon hellem, and the insect parasiteAnncaliia(Brachiola, Nosema) algerae, were used in spore germination and enterocyte-like (C2Bbe1) cell infection assays to determine the effect of a panel of antimicrobial peptides. Spores were incubated with lactoferrin (Lf), lysozyme (Lz), and human beta defensin 2 (HBD2), human alpha defensin 5 (HD5), and human alpha defensin 1 (HNP1), alone and in combination with Lz, prior to germination. Of theEncephalitozoonspecies onlyE. hellemspore germination was inhibit

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Mansour, Bassel, Ádám Monyók, Márió Gajdács, et al. "Bladder Tissue Microbiome Composition in Patients of Bladder Cancer or Benign Prostatic Hyperplasia and Related Human Beta Defensin Levels." Biomedicines 10, no. 7 (2022): 1758. http://dx.doi.org/10.3390/biomedicines10071758.

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Balance between the microbiome associated with bladder mucosa and human beta defensin (HBD) levels in urine is a dynamic, sensitive and host-specific relationship. HBD1—possessing both antitumor and antibacterial activity—is produced constitutively, while the inducible production of antibacterial HBD2 and HBD3 is affected by bacteria. Elevated levels of HBD2 were shown to cause treatment failure in anticancer immunotherapy. Our aim was to assess the relationship between microbiome composition characteristic of tumor tissue, defensin expression and HBD levels measured in urine. Tissue samples f

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Moranta, David, Verónica Regueiro, Catalina March та ін. "Klebsiella pneumoniae Capsule Polysaccharide Impedes the Expression of β-Defensins by Airway Epithelial Cells". Infection and Immunity 78, № 3 (2009): 1135–46. http://dx.doi.org/10.1128/iai.00940-09.

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ABSTRACT Human β-defensins (hBDs) contribute to the protection of the respiratory tract against pathogens. It is reasonable to postulate that pathogens have developed countermeasures to resist them. Klebsiella pneumoniae capsule polysaccharide (CPS), but not the lipopolysaccharide O antigen, mediated resistance against hBD1 and hBD2. hBD3 was the most potent hBD against Klebsiella. We investigated the possibility that as a strategy for survival in the lung, K. pneumoniae may not activate the expression of hBDs. Infection of A549 and normal human bronchial cells with 52145-Δwca K2, a CPS mutant

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15

Rue, Cary A., and Patrick Ryan. "Characterization of pseudorabies virus glycoprotein C attachment to heparan sulfate proteoglycans." Journal of General Virology 83, no. 2 (2002): 301–9. http://dx.doi.org/10.1099/0022-1317-83-2-301.

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Pseudorabies virus first attaches to cells through an interaction between the envelope glycoprotein C (gC) and the cell surface heparan sulfate (HS) that is linked to proteoglycans (HSPGs). The HS-binding domain of gC is composed of three discrete heparin-binding domains (HBDs), designated HBD1, -2 and -3 for their proximity to the amino terminus of gC. Each HBD can independently mediate virus attachment to HS, yet each also exhibits a distinct binding preference for differentially sulfated derivatives of heparin. To demonstrate this, affinity columns composed of wild-type gC or mutant gC reta

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Barrera, Jose, Sanchez Tortolero, Adriana Rivas, Carmen Flores та Emanuele Gonzales. "Increased expression and levels of human β defensins (hBD2 and hBD4) in adults with dental caries". Journal of Health Sciences 3, № 2 (2013): 88–97. http://dx.doi.org/10.17532/jhsci.2013.70.

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Introduction: Defensins are small anti-microbial peptides produced by epithelial cells. These peptides have a broad range of actions against microorganisms, including Gram-positive and Gram-negative bacteria.Human defensins are classifi ed into two subfamilies, the α-, and β- defensins, which differ in their distribution of disulphide bonds between the six conserved cysteine residues. Defensins are found in salivaand others compartments of the body. Human β defensins 2 (hBD2), beta defensins 4 (hBD4) and alpha defensins 4 (hNP4) in saliva may contributes to vulnerability or resistance to carie

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Zarina, Kaiva Zile, and Mara Pilmane. "Characterization of Angiogenic, Matrix Remodeling, and Antimicrobial Factors in Preterm and Full-Term Human Umbilical Cords." Journal of Developmental Biology 12, no. 2 (2024): 13. http://dx.doi.org/10.3390/jdb12020013.

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Background: Little is known about morphogenetic changes in the umbilical cord during the maturation process. Extracellular matrix remodeling, angiogenesis, progenitor activity, and immunomodulation are represented by specific markers; therefore, the aim of this study was to determine the expression of matrix metalloproteinase-2 (MMP2), tissue inhibitor of metalloproteinases-2 (TIMP2), CD34, vascular endothelial growth factor (VEGF), and human β-defensin 2 (HBD2) in preterm and full-term human umbilical cord tissue. Methods: Samples of umbilical cord tissue were obtained from 17 patients and di

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Fischer, Natalie, Emmanuel Sechet, Robin Friedman, et al. "Histone deacetylase inhibition enhances antimicrobial peptide but not inflammatory cytokine expression upon bacterial challenge." Proceedings of the National Academy of Sciences 113, no. 21 (2016): E2993—E3001. http://dx.doi.org/10.1073/pnas.1605997113.

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Antimicrobial peptides (AMP) are defense effectors of the innate immunity playing a crucial role in the intestinal homeostasis with commensals and protection against pathogens. Herein we aimed to investigate AMP gene regulation by deciphering specific characteristics allowing their enhanced expression among innate immune genes, particularly those encoding proinflammatory mediators. Our emphasis was on epigenetic regulation of the gene encoding the AMP β-defensin 2 (HBD2), taken as a model of possibly specific induction, upon challenge with a commensal bacterium, compared with the proinflammato

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Midorikawa, Kazushige, Kazuhisa Ouhara, Hitoshi Komatsuzawa та ін. "Staphylococcus aureus Susceptibility to Innate Antimicrobial Peptides, β-Defensins and CAP18, Expressed by Human Keratinocytes". Infection and Immunity 71, № 7 (2003): 3730–39. http://dx.doi.org/10.1128/iai.71.7.3730-3739.2003.

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ABSTRACT The antimicrobial peptides human β-defensin-1 (hBD1), hBD2, hBD3, and CAP18 expressed by keratinocytes have been implicated in mediation of the innate defense against bacterial infection. To gain insight into Staphylococcus aureus infection, the susceptibility of S. aureus, including methicillin-resistant S. aureus (MRSA), to these antimicrobial peptides was examined. Based on quantitative PCR, expression of hBD2 mRNA by human keratinocytes was significantly induced by contact with S. aureus, and expression of hBD3 and CAP18 mRNA was slightly induced, while hBD1 mRNA was constitutivel

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Coello, Daniel, Jeffery D. Knott, and Edith Porter. "In vitro model for assessing the effect of T helper cell cytokines on the barrier function of alveolar type II epithelial cells." Journal of Immunology 202, no. 1_Supplement (2019): 67.20. http://dx.doi.org/10.4049/jimmunol.202.supp.67.20.

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Abstract There are still diseases of global burden for which satisfactory vaccines are unavailable, e.g. tuberculosis. Vaccines against intracellular microbes has relied on the activation of the adaptive T cell response. Our laboratory is interested in investigating whether the innate epithelial host defense could be integrated in a novel approach. In response to airborne pathogens, airway epithelia release antimicrobial peptides like human beta defensin-2 and -3 (HBD2/3), antimicrobial lipids, and chemokines, like IL-8, to attract other immune cells including T helper cells that are integral

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Subramanian, Hariharan, Kshitij Gupta, Donguk Lee, Arzu Bayir, Harry Ahn та Hydar Ali. "β-defensins activate human mast cells via Mas-related Gene-X2: cross-regulation by LPS (P4179)". Journal of Immunology 190, № 1_Supplement (2013): 112.23. http://dx.doi.org/10.4049/jimmunol.190.supp.112.23.

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Abstract Human β-defensins (hBDs) stimulate degranulation in rat peritoneal mast cells and cause increased vascular permeability in wild-type but not mast cell-deficient rats. Here, we sought to determine if hBDs activate murine and human mast cells and to delineate the mechanisms of their regulation. hBD2 and hBD3 did not induce degranulation in murine peritoneal or bone marrow-derived mast cells in vitro and had no effect on vascular permeability in vivo. By contrast, they induced sustained Ca2+ mobilization and substantial degranulation in human mast cells with hBD3 being more potent. While

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Jung, Sascha, Justyna Mysliwy, Björn Spudy та ін. "Human β-Defensin 2 and β-Defensin 3 Chimeric Peptides Reveal the Structural Basis of the Pathogen Specificity of Their Parent Molecules". Antimicrobial Agents and Chemotherapy 55, № 3 (2010): 954–60. http://dx.doi.org/10.1128/aac.00872-10.

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ABSTRACTDespite partial sequence identity and structural similarity, human β-defensin 3 (HBD3) killsStaphylococcus aureuswith a 4- to 8-fold higher efficiency than human β-defensin 2 (HBD2), whereas the activities againstEscherichia coliare identical. The design and characterization of HBD2/HBD3 chimeric peptides revealed that distinct molecular regions are responsible for their divergent killing properties. Two of the chimeras killed bothE. coliandS. aureuswith an even higher efficacy than the wild-type molecules. Moreover, one of these two chimeras maintained its high killing activities in t

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PARK, JU YOUN, Jae-Ho Chang, Myong-Jo Kim та Soo-Ki Kim. "Urushiol regulates the expression of TLR2, HBD and TSLP via NF-κB pathway in Staphylococcus aureus-treated HaCaT cells (134.50)". Journal of Immunology 182, № 1_Supplement (2009): 134.50. http://dx.doi.org/10.4049/jimmunol.182.supp.134.50.

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Abstract TLR2, HBDs(beta-defensins) and TSLP(thymic stromal lymphopoietin) expressed from keratinocytes play key roles in controlling the progression of atopic dermatitis. These molecules might account for the accelerated colonization with S. aureus into eczematous skin barrier. In the course of screening natural substance in regulating TLR2, HBD and TSLP expression by using the inflamed keratinocytes, we found urushiol, major active ingredient of Rhus verniciflua Stokes which has been used as barrier protective in traditional medicine. The aim of this study was to clarify how urushiol regulat

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Filipe Rosa, Louisa, Andreas Rings, Iris Stolzer та ін. "Human α-Defensin 51–9 and Human β-Defensin 2 Improve Metabolic Parameters and Gut Barrier Function in Mice Fed a Western-Style Diet". International Journal of Molecular Sciences 24, № 18 (2023): 13878. http://dx.doi.org/10.3390/ijms241813878.

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Obesity and metabolic comorbidities are associated with gut permeability. While high-fructose and Western-style diet (WSD) disrupt intestinal barrier function, oral administration of human α-defensin 5 (HD5) and β-defensin 2 (hBD2) is believed to improve intestinal integrity and metabolic disorders. Eighty-four male C57BL/6J mice were fed a WSD or a control diet (CD) ± fructose (F) for 18 weeks. In week 13, mice were randomly divided into three intervention groups, receiving defensin fragment HD51–9, full-length hBD2, or bovine serum albumin (BSA)-control for six weeks. Subsequently, parameter

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Nguyen, Anh-Thu, Minho Kim, Ye-Eun Kim та ін. "MSF Enhances Human Antimicrobial Peptide β-Defensin (HBD2 and HBD3) Expression and Attenuates Inflammation via the NF-κB and p38 Signaling Pathways". Molecules 28, № 6 (2023): 2744. http://dx.doi.org/10.3390/molecules28062744.

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Both defensin and inflammation are part of the human innate immune system that responds rapidly to pathogens. The combination of defensins with pro- or anti-inflammatory effects can be a potential research direction for the treatment of infection by pathogens. This study aimed to identify whether MSF (Miracle Synergy material made using Filipendula glaberrima), a probiotic lysate of Filipendula glaberrima extracts fermented with Lactiplantibacillus plantarum K8, activates the expression of human β-defensin (HBD2 and HBD3) to protect the host against pathogens and inhibit inflammation caused by

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Hamanaka, Yoichi, Masahiro Nakashima, Masahiro Ito, et al. "Induction of human B-defensin-2 (hBD2) in Helicobacter pylori (HP)-induced gastritis: Antibacterial effect of hBD2 against for HP." Gastroenterology 118, no. 4 (2000): A741. http://dx.doi.org/10.1016/s0016-5085(00)85098-2.

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Seo, Emily S., Bärbel S. Blaum, Thomas Vargues та ін. "Interaction of Human β-Defensin 2 (HBD2) with Glycosaminoglycans". Biochemistry 49, № 49 (2010): 10486–95. http://dx.doi.org/10.1021/bi1011749.

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Dietrich, Deborah E., Xiangjun Xiao, Deborah V. Dawson та ін. "Human α- and β-Defensins Bind to Immobilized Adhesins from Porphyromonas gingivalis". Infection and Immunity 76, № 12 (2008): 5714–20. http://dx.doi.org/10.1128/iai.00997-08.

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ABSTRACT Human neutrophil peptide α-defensins (HNPs) and human β-defensins (HBDs) are small well-characterized peptides with broad antimicrobial activities and a diversity of innate immune functions. Although the interactions of defensins with bacteria and their membranes have been well characterized, the interactions of defensins with bacterial adhesins have not. Here we determine if HNPs and HBDs bind to the immobilized adhesins of Porphyromonas gingivalis strain 381, recombinant hemagglutinin B (rHagB) and recombinant fimbrillin A (rFimA), by surface plasmon resonance spectroscopy. Associat

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Promsong, Aornrutai, Jureeporn Chuerduangphui, Claire N. Levy, Florian Hladik, Surada Satthakarn, and Wipawee Nittayananta. "Effects of Ellagic Acid on Vaginal Innate Immune Mediators and HPV16 Infection In Vitro." Molecules 29, no. 15 (2024): 3630. http://dx.doi.org/10.3390/molecules29153630.

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Ellagic acid (EA) is a phenolic phytochemical found in many plants and their fruits. Vaginal epithelial cells are the first line of defense against pathogen invasion in the female reproductive tract and express antimicrobial peptides, including hBD2 and SLPI. This study investigated the in vitro effects of EA (1) on vaginal innate immunity using human vaginal epithelial cells, and (2) on HPV16 pseudovirus infection. Vaginal cells were cultured in the presence or absence of EA, and the expression of hBD2 and SLPI was determined at both transcriptional and translational levels. In addition, secr

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Grankovsky, V. A., E. P. Karpova, L. V. Gankovskaya, Ya S. Avalyan, E. D. Merkusheva, and E. V. Zinina. "Features of innate immunity in children with hypertrophy of the palatine tonsils." Medical Immunology (Russia) 26, no. 2 (2023): 263–70. http://dx.doi.org/10.15789/1563-0625-foi-2650.

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Hypertrophy of pharyngeal lymphoid tissue is among the most common problems in pediatric otorhinolaryngology, in particular, hypertrophy of the palatine tonsils. This disorder is characterized by increased size of a single or both palatine tonsils combined with various clinical symptoms. The principles of treatment in children with this pathology remain debatable, since the long-term effects of bilateral tonsillotomy are still not fully understood. The aim of the study was to assess the expression levels of genes encoding the innate immunity molecules (TLR4, HBD1, HBD2, IL1β) in the mucous mem

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Astuti, S. D., R. Nashichah, P. Widiyanti, et al. "Effectiveness of 650 nm red laser photobiomodulation therapy to accelerate wound healing post tooth extraction." Biomedical Photonics 13, no. 1 (2024): 4–15. http://dx.doi.org/10.24931/2413-9432-2024-13-1-4-15.

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After tooth extraction, there can be consequences involving injury to the tissue surrounding the extracted tooth, which may lead to severe problems such as inflammation and infection. The wound healing process comprises inflammation, proliferation, and remodeling phases. Photobiomodulation is a therapy form that utilizes the interaction of a light source with tissue. This interaction can activate an increase in Adenosine Triphosphate (ATP), which subsequently triggers a chain reaction leading to the creation of new blood vessels and an increase in the number of fibroblasts. This study used a r

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Jenke, A. C., J. Postberg, B. Mariel, et al. "S100A12 and hBD2 Correlate with the Composition of the Fecal Microflora in ELBW Infants and Expansion ofE. coliIs Associated with NEC." BioMed Research International 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/150372.

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Objective. To describe the development of the gut microbiota in extremely low birth weight (ELBW) infants with and without necrotizing enterocolitis (NEC) between April 2008 and December 2009, fecal microflora was prospectively analyzed in fecal samples of all ELBW infants using real-time PCR assays. In addition, fecal inflammatory were measured.Results. Fecal microflora established early in ELBW infants and microbiota composition remained stable over the first 28 days of life except for the prevalence ofC. difficilewhich decreased with decreasing antibiotic use. Infants who subsequently devel

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Arnold, M. F. F., A. F. Haag, S. Capewell, et al. "Partial Complementation of Sinorhizobium meliloti bacA Mutant Phenotypes by the Mycobacterium tuberculosis BacA Protein." Journal of Bacteriology 195, no. 2 (2012): 389–98. http://dx.doi.org/10.1128/jb.01445-12.

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ABSTRACTTheSinorhizobium melilotiBacA ABC transporter protein plays an important role in its nodulating symbiosis with the legume alfalfa (Medicago sativa). TheMycobacterium tuberculosisBacA homolog was found to be important for the maintenance of chronic murine infections, yet itsin vivofunction is unknown. In the legume plant as well as in the mammalian host, bacteria encounter host antimicrobial peptides (AMPs). We found that theM. tuberculosisBacA protein was able to partially complement the symbiotic defect of anS. melilotiBacA-deficient mutant on alfalfa plants and to protect this mutant

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Vargues, Thomas, Gareth Morrison, Emily Seo, et al. "Efficient Production of Human β-Defensin 2 (HBD2) in Escherichia coli." Protein & Peptide Letters 16, no. 6 (2009): 668–76. http://dx.doi.org/10.2174/092986609788490122.

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Shevchenko, Olga V., Alexander D. Voropaev, Ivan V. Bogdanov, Tatiana V. Ovchinnikova, and Ekaterina I. Finkina. "Effects of the Tobacco Defensin NaD1 Against Susceptible and Resistant Strains of Candida albicans." Pathogens 13, no. 12 (2024): 1092. https://doi.org/10.3390/pathogens13121092.

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Today, Candida albicans is still the most common cause of both local and life-threatening systemic candidiasis. The spread of resistant fungal strains has resulted in an urgent need to search for new promising antimycotics. Here, we investigated the antifungal action of the tobacco defensin NaD1 against susceptible and resistant to azoles and echinocandins strains of C. albicans. We demonstrated that NaD1 was equally effective and fungicidal against all tested strains. The MIC and MFC values were 6.25 and 12.5 µM, respectively. We showed for the first time that NaD1 could act synergistically n

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Deshmukh, Prashant, Shruti Mathur, Gejo Gangadharan, Gopinatha Krishnappa, Nandakumar Dalavaikodihalli Nanjaiah, and Balasundaram Padmanabhan. "Novel pyrano 1,3 oxazine based ligand inhibits the epigenetic reader hBRD2 in glioblastoma." Biochemical Journal 477, no. 12 (2020): 2263–79. http://dx.doi.org/10.1042/bcj20200339.

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Glioblastoma (GBM) is the most common primary brain malignancy, rarely amenable to treatment with a high recurrence rate. GBM are prone to develop resistance to the current repertoire of drugs, including the first-line chemotherapeutic agents with frequent recurrence, limiting therapeutic success. Recent clinical data has evidenced the BRD2 and BRD4 of the BET family proteins as the new druggable targets against GBM. In this relevance, we have discovered a compound (pyrano 1,3 oxazine derivative; NSC 328111; NS5) as an inhibitor of hBRD2 by the rational structure-based approach. The crystal st

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Salem, Abdelhakim, Rabeia Almahmoudi, Jaana Hagström та ін. "Human β-Defensin 2 Expression in Oral Epithelium: Potential Therapeutic Targets in Oral Lichen Planus". International Journal of Molecular Sciences 20, № 7 (2019): 1780. http://dx.doi.org/10.3390/ijms20071780.

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Human β-defensin 2 (hBD-2) is a potent antimicrobial peptide that participates in defense against invading bacteria. We recently showed that bacterial components and histamine, through histamine H4 receptor (H4R), are involved in the pathogenesis of the potentially malignant lesion, oral lichen planus (OLP). However, the underlying mechanisms remain unknown. We, therefore, investigated the role of hBD2–histamine crosstalk signaling in promoting OLP pathology. Biopsies from OLP and oral tongue squamous cell carcinoma (OTSCC) patients, and healthy controls were used. Two OTSCC cell lines and nor

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Grupp, Alexander, Martin Kimmel, Peter Fritz, et al. "The Expression Patterns of Peritoneal Defensins." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 27, no. 6 (2007): 654–62. http://dx.doi.org/10.1177/089686080702700611.

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Background Local defense mechanisms are important for the integrity of the peritoneum, but few details are known about the expression patterns of antimicrobial proteins such as human defensin in normal and damaged peritoneum. Methods Part A: The expression of different defensins in normal ( n = 12), inflamed ( n = 5), and metastatic peritoneum ( n = 4) and in cultured human peritoneal mesothelial cells was analyzed using mRNA and immunohistochemistry. Part B: Using immunohistochemistry the expression of different defensins was analyzed in different subgroups: healthy controls ( n = 25), patien

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Kim, MinJeong, Kui Young Park, Mi-Kyung Lee, Taewon Jin, and Seong Jun Seo. "Adiponectin Suppresses UVB-Induced Premature Senescence and hBD2 Overexpression in Human Keratinocytes." PLOS ONE 11, no. 8 (2016): e0161247. http://dx.doi.org/10.1371/journal.pone.0161247.

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Kim, MinJeong, Kui Young Park, Mi-Kyung Lee, Taewon Jin, and Seong Jun Seo. "Correction: Adiponectin Suppresses UVB-Induced Premature Senescence and hBD2 Overexpression in Human Keratinocytes." PLOS ONE 11, no. 9 (2016): e0162738. http://dx.doi.org/10.1371/journal.pone.0162738.

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Li, Jing, Michael Raghunath, Donald Tan, Ricky R. Lareu, ZhenCheng Chen, and Roger W. Beuerman. "Defensins HNP1 and HBD2 Stimulation of Wound-Associated Responses in Human Conjunctival Fibroblasts." Investigative Opthalmology & Visual Science 47, no. 9 (2006): 3811. http://dx.doi.org/10.1167/iovs.05-1360.

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Yamamoto, Eiji, Tomonori Takashi, Yoichi Morinaka, et al. "Interaction of two recessive genes, hbd2 and hbd3, induces hybrid breakdown in rice." Theoretical and Applied Genetics 115, no. 2 (2007): 187–94. http://dx.doi.org/10.1007/s00122-007-0554-9.

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White, John H. "Emerging Roles of Vitamin D-Induced Antimicrobial Peptides in Antiviral Innate Immunity." Nutrients 14, no. 2 (2022): 284. http://dx.doi.org/10.3390/nu14020284.

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Vitamin D deficiency, characterized by low circulating levels of calcifediol (25-hydroxyvitamin D, 25D) has been linked to increased risk of infections of bacterial and viral origin. Innate immune cells produce hormonal calcitriol (1,25-dihydroxyvitamin D, 1,25D) locally from circulating calcifediol in response to pathogen threat and an immune-specific cytokine network. Calcitriol regulates gene expression through its binding to the vitamin D receptor (VDR), a ligand-regulated transcription factor. The hormone-bound VDR induces the transcription of genes integral to innate immunity including p

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Porter, Edith, Huixia Yang, Sujata Yavagal, et al. "Distinct Defensin Profiles in Neisseria gonorrhoeae and Chlamydia trachomatis Urethritis Reveal Novel Epithelial Cell-Neutrophil Interactions." Infection and Immunity 73, no. 8 (2005): 4823–33. http://dx.doi.org/10.1128/iai.73.8.4823-4833.2005.

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ABSTRACT Defensins are key participants in mucosal innate defense. The varied antimicrobial activity and differential distribution of defensins at mucosal sites indicate that peptide repertoires are tailored to site-specific innate defense requirements. Nonetheless, few studies have investigated changes in peptide profiles and function after in vivo pathogen challenge. Here, we determined defensin profiles in urethral secretions of healthy men and men with Chlamydia trachomatis- and Neisseria gonorrhoeae-mediated urethritis by immunoblotting for the epithelial defensins HBD1, HBD2, and HD5 and

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Corrales-García, Ligia Luz, Leobardo Serrano-Carreón та Gerardo Corzo. "Improving the heterologous expression of human β-defensin 2 (HBD2) using an experimental design". Protein Expression and Purification 167 (березень 2020): 105539. http://dx.doi.org/10.1016/j.pep.2019.105539.

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Stanton, A., A. S. M. Ali, R. S. Pickard, and J. Hall. "140 Estrogen and hBD2 in the innate defence of the female uro-genital tract." European Urology Supplements 14, no. 2 (2015): e140. http://dx.doi.org/10.1016/s1569-9056(15)60142-7.

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Zhong, Zhixia, Zhinan Xu, Li Peng, Lei Huang, Xiangming Fang, and Peilin Cen. "Tandem repeat mhBD2 gene enhance the soluble fusion expression of hBD2 in Escherichia coli." Applied Microbiology and Biotechnology 71, no. 5 (2005): 661–67. http://dx.doi.org/10.1007/s00253-005-0212-6.

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ZONG, Zhao-Wen, Nan LI, Tao-Yuan XIAO, et al. "Effect of hBD2 Genetically Modified Dermal Multipotent Stem Cells on Repair of Infected Irradiated Wounds." Journal of Radiation Research 51, no. 5 (2010): 573–80. http://dx.doi.org/10.1269/jrr.10047.

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Li, Jing, Hong Yuan Zhu, and Roger W. Beuerman. "Stimulation of Specific Cytokines in Human Conjunctival Epithelial Cells by Defensins HNP1, HBD2, and HBD3." Investigative Opthalmology & Visual Science 50, no. 2 (2009): 644. http://dx.doi.org/10.1167/iovs.08-1838.

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Lafferty, Mark K., Lingling Sun, Wuyuan Lu, and Alfredo Garzino-Demo. "112 hBD2 inhibits HIV via CCR6, a receptor expressed on memory, Dendritic and Th17 cells." JAIDS Journal of Acquired Immune Deficiency Syndromes 51 (June 2009): 1. http://dx.doi.org/10.1097/01.qai.0000351069.36343.fa.

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