Log in

Relevant bibliographies by topics / HCV virus / Dissertations / Theses

To see the other types of publications on this topic, follow the link: HCV virus.

Dissertations / Theses on the topic 'HCV virus'

Author: Grafiati

Published: 24 April 2022

Last updated: 30 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'HCV virus.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Burke, Stephanie. "Generalized Impairment of CD8+ T-cells in HCV Mono- and HIV-HCV Co-infection." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32770.

Full text

Abstract:

Chronic hepatitis C virus (HCV) infection has global effects on the immune system. CD8+ T-cells, responsible for viral clearance and control, are dysfunctional for as yet unknown reasons. It is hypothesized that IL-7 signaling pathway deficiencies contribute to this impairment. Blood-derived CD8+ T-cells in chronic HCV mono- and HIV-HCV co-infection had lower IL-7-induced activation of STAT5 and production of Bcl-2, and lower proliferation in co-infection, compared to controls. Lower Bcl-2 production was also associated with increased fibrosis. These changes were independent of the IL-7 recep

APA, Harvard, Vancouver, ISO, and other styles

2

Marraiki, Najat A. Y. "Recombinant virus like particles comprising hepatitis C virus (HCV) structural proteins and HCV replicon RNA." Thesis, University of Leeds, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422629.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Matsukura, Motoi. "Highly active anti-retroviral therapy and liver mitochondrial toxicity in human immunodeficiency virus / hepatitis C virus co-infection." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/2517.

Full text

Abstract:

Background: A third of HIV-infected patients are co-infected with HCV in the developed world, and more of co-infected patients than ever before are dying because of liver related diseases today. Drug-related hepatotoxicity is a growing concern among human immunodeficiency virus (HIV) / hepatitis C virus (HCV) co-infected population. Nucleotide analogues containing HIV antiretroviral therapy, namely highly active anti-retroviral therapy (HAART), can induce mitochondrial toxicity. However, little is known about the effect of nucleotide analogues on the liver at the cellular and molecular level,

APA, Harvard, Vancouver, ISO, and other styles

4

Gao, Zhanhai School of Mathematics UNSW. "Modelling Human Immunodeficiency Virus and Hepatitis C Virus Epidemics in Australia." Awarded by:University of New South Wales. School of Mathematics, 2001. http://handle.unsw.edu.au/1959.4/18187.

Full text

Abstract:

This thesis is concerned with the mathematical modelling for human immunodeficiency virus (HIV) and hepatitis C virus (HCV) epidemics in Australia. There are two parts to this thesis. Part I is aimed at modelling the transmission of HIV and HCV via needle sharing among injecting drug users (IDUs). The dynamical model of an epidemic through needle sharing among IDUs is derived. This model reveals the correlation between needle sharing and the epidemic prevalence among IDUs. The simulations of HIV and HCV prevalence and incidence among IDUs in Australia are made with this model. The comparison

APA, Harvard, Vancouver, ISO, and other styles

5

Franco, Kelly Flory. "Hepatitis C virus (HCV) replication in vitroand the effect of HCV on human immunodeficiency virus (HIV-1) coreceptor usage and diversity in the coinfected patient." Cincinnati, Ohio : University of Cincinnati, 2007. http://rave.ohiolink.edu/etdc//view?acc_num=ucin1183474023.

Full text

Abstract:

Thesis (Ph.D.)--University of Cincinnati, 2007.<br>Advisor: Dr. Julie A.E. Nelson. Title from electronic thesis title page (viewed Dec. 22, 2009). Includes abstract. Includes bibliographical references.

APA, Harvard, Vancouver, ISO, and other styles

6

Reynolds, Joanna Elizabeth. "Initiation of hepatitis C virus RNA translation." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264546.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Li, Dongsheng. "The role of HCV core protein in the regulation of HCV replication /." St. Lucia, Qld, 2003. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18009.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Da, Costa Daniel. "Study of cell host factors involved in Hepatitis C virus tropism." Thesis, Strasbourg, 2012. http://www.theses.fr/2012STRAJ071/document.

Full text

Abstract:

Le virus de l’hépatite C (HCV) est un problème majeur de santé publique. Le développement de nouveaux traitements pour lutter contre le HCV a été ralenti par l’absence de modèles d’études in vitro et in vivo convenables. Le but de mon travail de thèse a été, dans un premier temps, de caractériser les facteurs déterminant le tropisme hépatique du HCV. En exprimant des facteurs clés dans une lignée cellulaire humaine non-hépatocytaire, nous avons reconstitué in fine l’ensemble du cycle viral dans ces cellules. L’entrée du virus dans la cellule hôte fait intervenir différents récepteurs d’entrée

APA, Harvard, Vancouver, ISO, and other styles

9

Tuthill, Tobias J. "Construction expression and preliminary biological analysis of HCV and HCV-dengue chimeric virus genomes." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368893.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Paterson, Caren Joan Isabella. "The development of a small animal model for hepatitis C virus (HCV) using chimeric HCV-BVDV (bovine viral diarrhoea virus) replicons." Thesis, Royal Veterinary College (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415668.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Harris, Kathryn Ann. "Genetic diversity and evolution of hepatitis C virus." Thesis, Open University, 2000. http://oro.open.ac.uk/58053/.

Full text

Abstract:

Inter- and intra-host Hey variation was investigated. First. a polymerase chain reactionrestriction fragment length polymorphism procedure was used to assign genotypes and subtypes to Hey infecting 567 individuals (comprising haemophilia patients, blood donors, intravenous drug users, attenders of antenatal and genito-urinary medicine clinics and chronic liver disease patients) from England and Wales. The majority of infections were associated with types 3a, 1 a and 1 b, and genotype distributions were generally similar in different sub-populations. Only 1 % of individuals were identified as b

APA, Harvard, Vancouver, ISO, and other styles

12

Franco, Kelly Flory. "Hepatitis C Virus (HCV) Replication In Vitroand the Effect of HCV on Human Immunodeficiency Virus (HIV-1) Coreceptor Usage and Diversity in the Coinfected Patient." University of Cincinnati / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1183474023.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Zhou, Yu. "HCV, Heroin Use, and MicroRNAs." Diss., Temple University Libraries, 2014. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/309425.

Full text

Abstract:

Pathology<br>Ph.D.<br>Hepatitis C virus (HCV) infection is common among injection drug users (IDUs). There is accumulating evidence that circulating microRNAs (miRNAs) are related to HCV infection and disease progression. The present study was undertaken to determine the in vivo impact of heroin use on HCV infection and HCV-related circulating miRNA expression. Using the blood specimens from four groups of study subjects (HCV-infected individuals, heroin users with/without HCV infection, and healthy volunteers), we found that HCV- infected heroin users had significantly higher viral load than

APA, Harvard, Vancouver, ISO, and other styles

14

Imhof, Ingrid. "Development of an intra- and intergenotypic HCV cell culture method to phenotype and assess antiviral susceptibilities and resistance development of HCV NS3 protease genes from HCV genotypes 1-6." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/6207.

Full text

Abstract:

The development of specific antiviral drugs directly targeting the hepatitis C virus (HCV) is clinically important, as the current standard interferon/ribavirin combination treatment is only partially effective, expensive and often associated with severe side effects. Inhibitors of the NS3 protease (PI) therefore represent a promising alternative or additional therapy. To date, the development and in vitro evaluation of PIs is restricted to the genotype 1/2 based replicon and the genotype 2a full length viral cell culture system. However, proteases of the different HCV genotypes vary substanti

APA, Harvard, Vancouver, ISO, and other styles

15

Potter, Martin. "Estimating variations between health care centres in the uptake of Hepatitis C Virus (HCV) treatment in HIV-HCV co-infected patients." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114160.

Full text

Abstract:

The effect of Health Care Centres on uptake of Hepatitis C Virus (HCV) treatment in HIV-HCV co-infected patientsBackgroundThe purpose of the study was to investigate the effect of health care centres on HCV treatment uptake after adjusting for case-mix variables. Methods Using data from the Canadian Co-infection Cohort, we modelled time to HCV treatment uptake using a Bayesian survival analysis model with random intercepts for each of the 16 cohort centres. To take into account variability in patient populations served at each centre (case-mix), models were adjusted for age, gender, ethnicity,

APA, Harvard, Vancouver, ISO, and other styles

16

Dao, Thi Viet Loan. "The Scavenger Receptor B1 is a multifunctional HCV entry factor." Thesis, Lyon, École normale supérieure, 2011. http://www.theses.fr/2011ENSL0650.

Full text

Abstract:

L’entrée cellulaire du virus de l’Hépatite C (VHC) est un processus complexe qui met en jeu plusieurs facteurs cellulaires. L’un d’eux est un récepteur des lipoprotéines, le « Scavenger Récepteur B1 » (SR-BI). SR-BI a initialement été proposé comme récepteur viral de par son interaction avec la glycoprotéine (GP) E2 du VHC. L’importance de SR-BI pour l’entrée cellulaire du VHC n’était, jusqu’alors suggérée que par des preuves indirectes. En outre, les mécanismes par lesquels SR-BI permet l’entrée du VHC restent peu connus. Néanmoins, grâce à l’identification de cellules hépatiques présentant u

APA, Harvard, Vancouver, ISO, and other styles

17

Owen, Rachel Elizabeth. "Immunomodulatory effects of the hepatitis C virus (HCV) core protein." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406416.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Schwarz, Anne-Katrin. "Defining the mechanism(s) of Hepatitis C virus (HCV) entry." Thesis, University of Birmingham, 2009. http://etheses.bham.ac.uk//id/eprint/475/.

Full text

Abstract:

Hepatitis C virus (HCV) is a major human pathogen and the leading cause of cirrhosis and liver cancer worldwide. HCV entry is clathrin- and pH-dependent, and requires CD81, Scavenger receptor BI (SR-BI), and the tight junction (TJ) proteins Claudin-1 and Occludin. Primary HCV strains cannot be efficiently cultured in vitro, making the evaluation of potential antiviral compounds in a biologically relevant context extremely difficult. Despite being suitable for high-throughput screening, most cell-based reporter assays rely on the secretion of serine alkaline phosphatase and thus do not allow th

APA, Harvard, Vancouver, ISO, and other styles

19

Maidens, Catherine. "Characterisation of hepatitis C virus envelope glycoprotein interactions with cellular receptors." Thesis, University of Reading, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340047.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Pumeechockchai, Wanna. "Density heterogeneity of hepatitis C virus RNA in immunocompetent and immunodeficient patients." Thesis, University of Newcastle Upon Tyne, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324936.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Jung, Dorothy Eunhyun. "CD4+ T cell discordance in HIV-infected patients with and without hepatitis C virus (HCV)-coinfection." Thesis, Boston University, 2012. https://hdl.handle.net/2144/31572.

Full text

Abstract:

Thesis (M.A.)--Boston University<br>PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>HIV infected patients with hepatitis C virus (HCV) infection are at increased risk of faster fibrosis progression and end-stage liver disease compared to patients with HCV alone. Why HIV /HCV -coinfected patie

APA, Harvard, Vancouver, ISO, and other styles

22

Lévy, Pierre. "Hepatitis C virus-induced reprogramming of glutamine metabolism." Thesis, Lyon 1, 2014. http://www.theses.fr/2014LYO10328.

Full text

Abstract:

L'hépatite C chronique est une des étiologies principales du carcinome hépatocellulaire. En revanche, les mécanismes de tumorigenèse sont peu connus. Récemment, plusieurs modifications du métabolisme du glucose ont été décrites dans les cellules infectées par le HCV. Celles-ci évoquent les reprogrammations métaboliques mises en place dans les cellules cancéreuses. L'effet Warburg, ou glycolyse aérobie, est une des caractéristiques principales des cellules tumorales. Ce phénomène permet d'assurer une production énergétique ainsi qu'un stock en précurseurs de macromolécules suffisants pour perme

APA, Harvard, Vancouver, ISO, and other styles

23

Shawa, Isaac Thom. "Protection from HCV infection : identification of mechanisms of resistance to HCV infection in exposed uninfected injection drug users." Thesis, University of Plymouth, 2017. http://hdl.handle.net/10026.1/10386.

Full text

Abstract:

Hepatitis C virus (HCV) is a leading cause of chronic liver disease. In the developed world, injection drug use (IDU) through sharing of infected needles and other paraphernalia remains the principal risk factor for HCV transmission. Effective but expensive treatment is now possible but there remains a pressing need for a vaccine. A proportion of people who inject drugs (PWIDs) remain uninfected despite HCV exposure from a long history of sharing needles and other paraphernalia. These cases are termed exposed but uninfected (EU) and test negative for both HCV antibodies and RNA and exhibit a p

APA, Harvard, Vancouver, ISO, and other styles

24

Denolly, Solène. "HCV assembly : from clustering of viral assembly factors to envelopment and lipidation of particles." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1085/document.

Full text

Abstract:

Le virus de l'hépatite C (VHC) est détecté dans les sérums de patients infectés sous forme de particules infectieuses lipidées de très faibles densités. Le VHC est un virus enveloppé dont l'assemblage de particules virales se produit à la membrane du réticulum endoplasmique consécutivement au clivage séquentiel de sa polyprotéine et à sa maturation en protéines structurales et non structurales. Dans ce travail, nous avons cherché à mieux comprendre les mécanismes d'assemblage, d'enveloppement et de sécrétion des particules infectieuses. Dans une première étude, nous avons montré la connexion f

APA, Harvard, Vancouver, ISO, and other styles

25

Abdulhaq, Ahmed Abdulhaq. "Activation of monocyte derived dendritic cells (MoDCs) by hepatitis C virus (HCV) glycoproteins." Thesis, University of Nottingham, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.555701.

Full text

Abstract:

Hepatitis C Virus causes a persistent, chronic infection in more than 80% of the estimated 170 million infections worldwide. Persistent infection can lead to complications such as cirrhosis and hepatocellular carcinoma. Around 20% of HCV infected patients are able to spontaneously clear the infection. HCV glycoprotein E2 mediates HCV entry, and as such is the primary target for recognition by immune response. Production of broadly neutralizing antibodies to the E2 protein correlates with spontaneous clearance. However, antibody production requires efficient antigen presentation. Dendritic cell

APA, Harvard, Vancouver, ISO, and other styles

26

Auma, Ann Winniefred Nangobi. "THE IMPACT OF DIRECT-ACTING ANTI-VIRAL THERAPY ON NAIVE CD4+ T CELL LYMPHOPENIA AND CELLULAR IMMUNE ACTIVATION IN HCV INFECTION AND HCV/HIV CO-INFECTION." Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1625764728651756.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Iles, James C. "The molecular epidemiology of HCV and related viruses in Africa." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:8eb2d243-9918-48d5-acec-0886c8d3b254.

Full text

Abstract:

Hepatitis C virus (HCV) causes severe illness in millions of people worldwide, but the epidemic strains responsible for most infections arose within the past hundred years and represent only a small part of total HCV diversity. In this thesis I combine laboratory and computational methods to study HCV in Africa. I aim to characterize its current genetic diversity and its historical transmission prior to the global HCV epidemic. In Chapter 2 I begin by screening samples from the Democratic Republic of the Congo (DRC) for HCV and the related human pegivirus. I find high HCV sequence diversity, i

APA, Harvard, Vancouver, ISO, and other styles

28

Da, Costa Daniel. "Etude des facteurs cellulaires de l'hôte impliqués dans le tropisme du virus de l'hépatite C." Phd thesis, Université de Strasbourg, 2012. http://tel.archives-ouvertes.fr/tel-00804227.

Full text

Abstract:

Le virus de l'hépatite C (HCV) est un problème majeur de santé publique. Le développement de nouveaux traitements pour lutter contre le HCV a été ralenti par l'absence de modèles d'études in vitro et in vivo convenables. Le but de mon travail de thèse a été, dans un premier temps, de caractériser les facteurs déterminant le tropisme hépatique du HCV. En exprimant des facteurs clés dans une lignée cellulaire humaine non-hépatocytaire, nous avons reconstitué in fine l'ensemble du cycle viral dans ces cellules. L'entrée du virus dans la cellule hôte fait intervenir différents récepteurs d'entrée

APA, Harvard, Vancouver, ISO, and other styles

29

Fiocco, Daniela. "α-DEFENSINS EXPRESSION IN PERIPHERAL BLOOD MONONUCLEAR CELLS FROM PATIENTS WITH HEPATITIS C VIRUS INFECTIONS". Doctoral thesis, La Sapienza, 2005. http://hdl.handle.net/11573/916796.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Bradshaw, Daniel Mark. "Defining risk factors and mechanisms of permucosal transmission of HCV amongst HIV-infected men who have sex with men." Thesis, University of Cambridge, 2016. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709469.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Wiklund, Lisa. "Role of the 3'UTR in translation and stability of HCV and HPV mRNAs." Doctoral thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3017.

Full text

Abstract:

<p>Virus mRNAs can be divided into functional regions. The focus of this thesis will be to investigate the function of one of these regions, the 3’ untranslated region (UTR). The 3’UTR of HCV contains a U-rich element and the late 3’UTR of HPV-1 contains an AU-rich element. The roles of these regions in translation and stability of HCV and HPV have been studied. </p><p>A method was established for studying translation of HCV mRNA in living cells. Noninfectious minivirus clones were synthesised <i>in vitro </i>and were transfected into cells by electroporation. This made it possible to bypass t

APA, Harvard, Vancouver, ISO, and other styles

32

Kania, Dramane. "Développement d’outils et de stratégies pour le diagnostic et le suivi biologique des infections VIH, VHB et VHC dans les pays à ressources limitées." Thesis, Montpellier 1, 2014. http://www.theses.fr/2014MON1T017/document.

Full text

Abstract:

Le diagnostic et le suivi des infections par le VIH, VHB et VHC restent un défi dans les pays à faibles ressources qui sont par ailleurs les plus touchés. Il est urgent de pouvoir disposer d'outils de biologie simples, fiables et peu chers pour le contrôle de ces infections virales. Le défi est immense d'un point de vue clinique et politique de santé. L'objectif de ce travail de recherche effectué dans le cadre de la présente thèse est de développer et valider des stratégies et de nouveaux outils de biologie adaptés au diagnostic et au suivi des hépatites virales et de l'infection VIH dans les

APA, Harvard, Vancouver, ISO, and other styles

33

Delcorde, Julie. "Investigating Host-Viral Interactions in Liver Lipid Homeostasis and HCV Pathology." Thesis, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31184.

Full text

Abstract:

Hepatitis C virus (HCV) infects an estimated 170 million people worldwide and is a major cause of chronic hepatitis and hepatocellular carcinoma. As there are limited treatment options, the elucidation of novel host-viral interactions during HCV pathogenesis will be critical for the development of new therapeutics. My thesis work has identified cell death-inducing DFF45-like effector B (CIDEB) as a host factor that is disregulated during HCV infection, and has delineated the relevance of CIDEB’s dual roles in apoptosis and lipid metabolism in the context of the HCV lifecycle. Moreover, additi

APA, Harvard, Vancouver, ISO, and other styles

34

Vilar, Fernando Crivelenti. "Expressão do HLA-G no tecido hepático de pacientes coinfectados com HIV/HCV." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/17/17138/tde-24082014-194222/.

Full text

Abstract:

A doença hepática crônica causada pelo vírus da hepatite C (HCV) tornou-se, nos últimos anos, uma das principais comorbidades dos pacientes portadores do vírus da imunodeficiência humana (HIV) nos países desenvolvidos. Os pacientes coinfectados com HIV/HCV apresentam uma progressão mais rápida para a cirrose e as suas complicações que os pacientes monoinfectados com HCV. Embora os mecanismos responsáveis por esta evolução não estejam totalmente esclarecidos, a expressão da molécula de HLA-G, um HLA de classe Ib não clássico, que tem propriedades bem reconhecidas na regulação negativa da respos

APA, Harvard, Vancouver, ISO, and other styles

35

Swayne, Cheryl. "Barriers to mental health services for homeless adults with Hepatitis C virus (HCV) infection." Thesis, Northern Kentucky University, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3606126.

Full text

Abstract:

<p> This action research study explored the complex nature of homeless adults and their perceptions of barriers to mental health services. Barriers to mental health services and a lack of resources for homeless adults are social justice issues explored in the study. The participants were homeless adults with a history of substance abuse, diagnosis of Hepatitis C (HCV) infection, and mental illness. A qualitative approach allowed for data analysis which described the experiences of homeless adults living with HCV infection. Due to the stigma assigned by HCV based on the prevalence of HCV being

APA, Harvard, Vancouver, ISO, and other styles

36

Thompson, Susan Lynn. "Provider Identification of Hepatitis C Virus (HCV) Risk Factors at Inmate Intake to Prison." Diss., The University of Arizona, 2015. http://hdl.handle.net/10150/560731.

Full text

Abstract:

The hepatitis C virus (HCV) disproportionately affects the prison population. Studies demonstrate that healthcare provider knowledge of HCV risk factors is insufficient and many individuals are not aware that they are HCV positive. Early identification of HCV status can prompt early treatment and avoidance of complications that contribute to poor outcomes resulting in chronic disease progression. This doctor of nursing practice (DNP) project addresses provider identification of HCV risk factors at initial inmate intake to prison and whether providers obtained HCV testing based on guidelines

APA, Harvard, Vancouver, ISO, and other styles

37

Haddad, Juliano. "Etude biochimique et fonctionnelle de la glycoprotéine E1 du virus de l'Hépatite C (HCV)." Thesis, Lille 2, 2017. http://www.theses.fr/2017LIL2S029/document.

Full text

Abstract:

Du fait de leur présence à la surface de la particule virale, les glycoprotéines d’enveloppe E1 et E2 du virus HCV jouent un rôle essentiel dans sa morphogenèse ainsi que lors de son entrée dans la cellule hôte. Jusqu’à récemment, les travaux de recherche sur les glycoprotéines d’enveloppe du virus HCV se sont essentiellement focalisés sur E2 car elle est la protéine d’attachement du virus. De plus, elle est la cible majeure des anticorps neutralisants et il a été longtemps postulé qu’elle était la protéine de fusion du virus. Cependant, les récentes publications de la structure de E2 ne mette

APA, Harvard, Vancouver, ISO, and other styles

38

Verlengia, Rozangela. "Otimização da nested-PCR em turbo unico na detecção do RNA-HCV." [s.n.], 1999. http://repositorio.unicamp.br/jspui/handle/REPOSIP/288206.

Full text

Abstract:

Orientador: Mario Hiroyuki Hirata<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-07-26T02:58:17Z (GMT). No. of bitstreams: 1 Verlengia_Rozangela_D.pdf: 5111418 bytes, checksum: a1316bcb3d2aaf4caa88f93aad39b0e2 (MD5) Previous issue date: 1999<br>Resumo: No presente estudo foi otimizado uma metodologia de nested-PCR em tubo único para a detecção do RNA-HCV. As condições da nested-PCR em tubo único foram estabelecidas utilizando um controle recombinante, produzido pela amplificação da região 5'-UTR do genoma do

APA, Harvard, Vancouver, ISO, and other styles

39

Yao, Felix Caspar. "Investigation on the risk of viral infection in musculoskeletal grafts." University of Western Australia. School of Surgery, 2010. http://theses.library.uwa.edu.au/adt-WU2010.0068.

Full text

Abstract:

[Truncated abstract] Around 50,000 hip and knee replacements are performed every year in Australia and this number has been increasing by around 13% annually since 1998 (Transplantation Society 2006). The incidence and number of revision surgery has increased by a similar proportion. Autogenous bone or allograft is still the gold standard grafting material and is currently used in a variety of reconstructive surgical procedures. The use of any allograft material carries with it the risk of transfer of disease from donor to recipient. These tissues can transmit the same viral and bacterial infe

APA, Harvard, Vancouver, ISO, and other styles

40

Jaubert, Chloe. "Extrémités 3’ de l’ARN du Virus de l’Hépatite C : structures et Rôles dans la réplication du génome." Thesis, Bordeaux, 2016. http://www.theses.fr/2016BORD0219/document.

Full text

Abstract:

Le génome du virus de l’Hépatite C est constitué d’un ARN monocaténaire linéaire de polarité positive (+). Les interactions ARN-ARN prennent une place essentielle dans la régulation du cycle viral.La synthèse de l’ARN est réalisée par l’ARN-polymérase ARN-dépendante (RdRp) codée par le virus. Elle serait initiée à l’extrémité 3’ des molécules à répliquer. Un ARN génomique complémentaire de polarité négative (-) est d’abord synthétisé. Il sert ensuite de matrice pour la production des brins génomiques. Les mécanismes qui président au recrutement de la polymérase et à l’initiation de la synthèse

APA, Harvard, Vancouver, ISO, and other styles

41

Blaising, Julie Élisabeth Françoise. "Étude des mécanismes moléculaires des inhibiteurs de l'entrée du virus de l'hépatite C (HCV) Silibinine et Arbidol : microenvironnement hépatique et infection par le HCV." Thesis, Lyon 1, 2013. http://www.theses.fr/2013LYO10235.

Full text

Abstract:

Le virus de l'hépatite C (HCV) infecte environ 180 millions de personnes à travers le monde. De nouveaux antiviraux ont récemment été mis sur le marché mais ils présentent des effets indésirables. La recherche de nouvelles cibles thérapeutiques reste donc d'actualité. Mes principaux travaux ont consisté à développer des approches de biochimie et d'imagerie sur cellules vivantes pour étudier les mécanismes moléculaires d'action des antiviraux silibinine (SbN) et arbidol (ARB) sur HCV. Nous avons montré que SbN et ARB inhibent des vésicules entourées de clathrine et ne sont pas délivrés aux endo

APA, Harvard, Vancouver, ISO, and other styles

42

Wing, Peter Alexander Cornelius. "Reduced sensitivity of Genotype 3 hepatitis C virus to direct acting antivirals." Thesis, Queen Mary, University of London, 2018. http://qmro.qmul.ac.uk/xmlui/handle/123456789/44044.

Full text

Abstract:

Sofosbuvir is a uridine based nucleotide inhibitor of the hepatitis C viral (HCV) polymerase that is the backbone of many treatment regimens. In combination with drugs targeting other viral enzymes (including the poorly potent guanosine analogue ribavirin or highly potent inhibitors of viral NS5A or protease) most patients clear virus and resistance to sofosbuvir is rare, allowing effective retreatment with sofosbuvir. Patients with Genotype 3 HCV respond less well than other genotypes and response is reduced in those previously exposed to interferon. Here we show that patientderived virus fro

APA, Harvard, Vancouver, ISO, and other styles

43

MAGRI, ANDREA. "Exploration of new uracil-based compounds as novel inhibitors of Hepatitis C Virus replication." Doctoral thesis, Università del Piemonte Orientale, 2016. http://hdl.handle.net/11579/115181.

Full text

Abstract:

Hepatitis C Virus (HCV) is a major public health problem worldwide. While highly efficacious directly-acting antiviral agents have been developed in recent years, their high costs and relative inaccessibility make their use limited. In this thesis, new uracil-based compounds have been evaluated as potential antiviral drugs against HCV. Using several biochemical and virological assays to investigate virus infection and replication, it has been shown that these compounds are able to significantly reduce viral genomic replication with their IC50 values in the nanomolar range. Finally, these compo

APA, Harvard, Vancouver, ISO, and other styles

44

Pearce, Emma St Clair. "Development of antibodies and characterisation of the humoral immune responses in a surrogate animal model for hepatitis C virus (HCV)." Thesis, Queen Mary, University of London, 2017. http://qmro.qmul.ac.uk/xmlui/handle/123456789/25978.

Full text

Abstract:

Hepatitis C virus (HCV) infection has become a global public health concern with over 130 million people chronically infected and over 350,000 deaths every year from HCV-related liver diseases. GB virus-B (GBV-B) infection in tamarins is a surrogate model for acute HCV infection. Whilst HCV infection commonly leads to chronicity, GBV-B is naturally cleared. To better understand this natural clearance, this project aimed to study the associated humoral immune response to GBV-B. Additionally, GBV-B-specific antibodies were produced with the aim of characterising the pathology of the virus. Previ

APA, Harvard, Vancouver, ISO, and other styles

45

Soare, Catalina P. "Characterization of Liver Damage Mechanisms Induced by Hepatitis C Virus." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20343.

Full text

Abstract:

Hepatitis C Virus (HCV) is one of the most important causes of chronic liver disease, affecting more than 170 million people worldwide. The mechanisms of hepatitis C pathogenesis are unknown. Viral cytotoxicity and immune mediated mechanisms might play an important role in its pathogenesis. HCV infection and alcohol abuse frequently coexist and together lead to more rapid progression of liver disease, increasing the incidence and prevalence of cirrhosis and hepatocellular carcinoma. The cytopathic effect of HCV proteins, especially the core, E1 and E2 structural proteins, which induce liver st

APA, Harvard, Vancouver, ISO, and other styles

46

Berg, Thomas. "Chronische Hepatitis C." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2002. http://dx.doi.org/10.18452/13812.

Full text

Abstract:

Die vorliegende Habilitationsschrift befasst sich schwerpunktmäßig vor allem mit der Klinik und Therapie der Hepatitis C. Evaluiert wurden: 1. verschiedene therapeutische Strategien, 2. die Ursachen der "Non-Response" auf eine anti-virale Therapie sowie 3. die klinische Relevanz der neu entdeckten Hepatitis-assoziierten Viren und 4. ihre Bedeutung bei Patienten mit akuter bzw. chronischer Lebererkrankung unklarer Ätiologie sowie bei Patienten vor und nach Lebertransplantation. Ad 1. Aus dem Vergleich verschiedener Therapie-Konzepte wie der Kurzzeit- Kombinationstherapie, Triple-Therapie

APA, Harvard, Vancouver, ISO, and other styles

47

Alabdullah, Bader Saleh. "Synthesis of Novel Nucleoside Analogs Targeting HCV." University of Toledo / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1524827142181671.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Turek, Marine. "Etude des facteurs cellulaires responsables de l'initiation et de la dissémination du virus de l'hépatite C." Thesis, Strasbourg, 2013. http://www.theses.fr/2013STRAJ123/document.

Full text

Abstract:

Le VHC est une cause majeure de cancer du foie. Le traitement actuel est caractérisé par à un cout élevé, la présence de toxicité et l’émergence de résistance virale. Dans la 1ère partie de ma thèse, je me suis intéressé à l’entrée virale. L’entrée est nécessaire pour l’initiation ; la dissémination et le maintien de l’infection et représente ainsi une cible intéressante dans le développement de thérapies antivirales : CD81 et SRBI sont les 1ers facteurs décrits comme importants pour l’entrée : Nous avons confirmé leur rôle clé dans l’entrée et les étapes suivant l’entrée. De plus, nous avons

APA, Harvard, Vancouver, ISO, and other styles

49

Cheng, Pui-sai. "Evaluation and comparison of genotyping assays for molecular epidemiological study of HCV in Hong Kong /." View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38297231.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Cheng, Pui-sai, and 鄭佩茜. "Evaluation and comparison of genotyping assays for molecular epidemiological study of HCV in Hong Kong." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B45011126.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!