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Journal articles on the topic 'HCV virus'

Author: Grafiati

Published: 24 April 2022

Last updated: 30 July 2025

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1

Shen, Yu-Chuan, Hui-Ching Hsu, Tzu-Min Lin, et al. "H1-Antihistamines Reduce the Risk of Hepatocellular Carcinoma in Patients With Hepatitis B Virus, Hepatitis C Virus, or Dual Hepatitis B Virus-Hepatitis C Virus Infection." Journal of Clinical Oncology 40, no. 11 (2022): 1206–19. http://dx.doi.org/10.1200/jco.21.01802.

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PURPOSE H1-antihistamines (AHs) may exert protective effects against cancer. This study investigated the association of AH use with the risk of hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV), hepatitis C virus (HCV), or dual HBV-HCV virus infection. MATERIALS AND METHODS Patients with HBV, HCV, or dual HBV-HCV infection were enrolled from Taiwan's National Health Insurance Research Database and examined for the period from January 1, 2006, to December 31, 2015. We used the Kaplan-Meier method and Cox proportional hazards regression to evaluate the association between A

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Lu, Meng-Chuan, Ying-Hsuen Wu, Chi-Hsiang Chung, et al. "Association of Hepatitis B and C Virus with the Risk of Coronary Artery Disease and Cerebrovascular Disease in Patients with Hepatocellular Carcinoma." Journal of Clinical Medicine 12, no. 7 (2023): 2602. http://dx.doi.org/10.3390/jcm12072602.

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Background: Hepatocellular carcinoma accounts for approximately 90% of primary liver cancers and hepatitis virus was believed to have the potential for altering the pathogenesis of arteriosclerosis. However, the influence of the hepatitis virus on coronary artery disease or cerebral vascular disease remains unclear. This study used the Taiwan National Health Insurance Research Database to clarify the virus-associated risk of coronary artery disease and cerebral vascular disease in patients with hepatocellular carcinoma (HCC). Methods: A total of 188,039 HCC individuals, age 20 years or older,

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Petruzziello, Arnolfo. "Epidemiology of Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) Related Hepatocellular Carcinoma." Open Virology Journal 12, no. 1 (2018): 26–32. http://dx.doi.org/10.2174/1874357901812010026.

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Introduction:Hepatocellular carcinoma (HCC) is one of the most prevalent primary malignant tumors and accounts for about 90% of all primary liver cancers. Its distribution varies greatly according to geographic location and it is more common in middle and low- income countries than in developed ones especially in Eastern Asia and Sub Saharan Africa (70% of all new HCCs worldwide), with incidence rates of over 20 per 100,000 individuals.Explanation:The most important risk factors for HCC are Hepatitis B Virus (HBV) infection, Hepatitis C Virus (HCV) infection, excessive consumption of alcohol a

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Alhamadany, Alaa Younis Mahdy, and Wajdi Sabeeh Sadek. "Analysis of the Chromosomal Aberrations in Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), and Hepatocellular Carcinoma Patients (HCC) in Mosul City, Iraq." NTU Journal of Pure Sciences 1, no. 2 (2022): 48–53. http://dx.doi.org/10.56286/ntujps.v1i2.210.

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Abstract. Hepatocellular carcinoma (HCC) (also known as liver cancer) is one of the most frequent cancers in humans. HCC is linked to chronic hepatitis B and C virus infection, cirrhosis, and excessive alcohol consumption. The aim of this study was to use Metaphase chromosome analysis in whole blood to determine chromosomal aberrations (CA) in HBV, HCV, and HCC patients. A cohort of 145 samples have been collected from participants from the date of 5 \ 1 \ 2020 to 15\9\ 2021. Among those samples are (40 healthy controls, HBV 38, 44 HCV, and HCC 23) to make cytogenetic evaluation by observing t

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Dickson-Spillmann, Maria, Severin Haug, Ambros Uchtenhagen, Philip Bruggmann, and Michael P. Schaub. "Rates of HIV and Hepatitis Infections in Clients Entering Heroin-Assisted Treatment between 2003 and 2013 and Risk Factors for Hepatitis C Infection." European Addiction Research 22, no. 4 (2015): 181–91. http://dx.doi.org/10.1159/000441973.

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Background/Aims: We report on the rates of hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) in 1,313 clients entering heroin-assisted treatment (HAT) in Switzerland from 2003 to 2013. We identify predictors of HCV infection. Methods: Data were collected using questionnaires within 2 weeks of clients' first entry into HAT. Prevalence of HAV, HBV, HCV and HIV was calculated using laboratory test results collected at entry or using reports of older test results. Predictors of HCV status were identified through multiple logistic regre

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Mujeeb, Syed Abdul, Qamar Jamal, Rafique Khanani, Nayyer Iqbal, and Shahnaz Kaher. "Prevalence of Hepatitis B Surface Antigen and HCV Antibodies in Hepatocellular Carcinoma Cases in Karachi, Pakistan." Tropical Doctor 27, no. 1 (1997): 45–46. http://dx.doi.org/10.1177/004947559702700117.

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Hepatocellular carcinoma (HCC) is a common cancer the world over. In Pakistan it has an incidence of 8/100 000 per annum. To assess the prevalence of Hepatitis B virus (HBV) and Hepatitis C virus (HCV) infections in biopsy proven cases of HCC a serological study was conducted at Screening Laboratory of Blood Transfusion Services, Jinnah Postgraduate Medical Centre. Of 54 sera of HCC tested for HBV and HCV infections, 67% showed HBV infection, and 33% HCV infection. Among them 24% were positive for both HBV and HCV infections. No HBV and HCV infection was found in 24% cases of HCC. Our findings

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Fang, Lily, Amanda Yu, and Jane A. Buxton. "Identification of Acute Vaccine-Preventable Hepatitis in Individuals with Chronic Hepatitis in British Columbia between 1991 and 2007." Canadian Journal of Infectious Diseases and Medical Microbiology 22, no. 1 (2011): 10–14. http://dx.doi.org/10.1155/2011/564290.

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BACKGROUND: In British Columbia (BC), hepatitis A virus (HAV) and hepatitis B virus (HBV) vaccines are provincially funded for persons with chronic hepatitis infections. PURPOSE: To assess the effectiveness of BC public health follow-up of HBV and hepatitis C virus (HCV) cases and immunization policy by determining the number of vaccine-preventable acute hepatitis infections reported following a chronic HBV or HCV diagnosis, by examining demographic characteristics and by observing temporal trends.METHODS: All newly identified cases of HAV, HBV and HCV between 1991 and October 2007 were extrac

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Stroffolini, Tommaso, and Giacomo Stroffolini. "A Historical Overview on the Role of Hepatitis B and C Viruses as Aetiological Factors for Hepatocellular Carcinoma." Cancers 15, no. 8 (2023): 2388. http://dx.doi.org/10.3390/cancers15082388.

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Hepatitis B virus (HBV) and hepatitis C virus (HCV) are the leading cause of hepatocellular carcinoma (HCC) worldwide. Currently, HBV-related HCC predominates in Sub-Saharan Africa and South-East-Asia, while HCV-related HCC predominates in northern Africa and in the western world. Liver cirrhosis is the underlying condition in most HBV cases and in nearly all HCV cases. Several cofactors, viral and non-viral, play a role in the progression toward HCC: dual HBV/HCV infection, HDV, HIV, alcohol intake, smoking, diabetes mellitus, obesity, and NAFLD/NASH. HBV vaccine is effective in preventing bo

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9

Buxton, Jane A., and Jin Hee Kim. "Hepatitis A and Hepatitis B Vaccination Responses in Persons with Chronic Hepatitis C Infections: A Review of the Evidence and Current Recommendations." Canadian Journal of Infectious Diseases and Medical Microbiology 19, no. 2 (2008): 197–202. http://dx.doi.org/10.1155/2008/410362.

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In persons with chronic hepatitis C virus (HCV) infections, superinfection by hepatitis A virus (HAV) or hepatitis B virus (HBV) can cause serious complications, including fulminating hepatitis or increased severity of hepatitis. Therefore, it is important to adequately protect persons with chronic HCV infections by immunization. Suboptimal response to vaccines has been reported in patients with chronic liver disease. The present article reviews HAV and HBV vaccine responses reported in the literature when administered to individuals with chronic HCV infection, and reviews current national and

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Shao, Yu Yun, Min-Shu Hsieh, Chung-Yi Huang, Yung-Ling Chang, Chih-Hung Hsu, and Ann-Lii Cheng. "Vascular endothelial growth factor expression in hepatitis C virus (HCV)-related advanced hepatocellular carcinoma (HCC) compared with hepatitis B virus (HBV)-related advanced HCC." Journal of Clinical Oncology 31, no. 15_suppl (2013): 4115. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.4115.

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4115 Background: HCC with different etiologic factors may result in activation of different signaling pathways. This study aimed to clarify if HBV-related HCC (HBV-HCC) and HCV-related HCC (HCV-HCC) may have difference in the expression of key molecules that are relevant to contemporary molecular targeted therapy. Methods: We enrolled patients diagnosed with advanced HCC from 2001 to 2011 who had tumor tissues obtained upon the diagnosis of advanced HCC at our center. Tumor slides were immunohistochemically stained for phosphorylated extracellular signal-regulated kinases (p-ERK), Raf kinase i

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Navas, Maria-Cristina, Iris Suarez, Andrea Carreño, et al. "Hepatitis B and Hepatitis C Infection Biomarkers and TP53 Mutations in Hepatocellular Carcinomas from Colombia." Hepatitis Research and Treatment 2011 (October 31, 2011): 1–10. http://dx.doi.org/10.1155/2011/582945.

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Hepatocellular Carcinoma (HCC) is a leading cause of cancer-related death worldwide. Globally, the most important HCC risk factors are Hepatitis B Virus (HBV) and/or Hepatitis C Virus (HCV), chronic alcoholism, and dietary exposure to aflatoxins. We have described the epidemiological pattern of 202 HCC samples obtained from Colombian patients. Additionally we investigated HBV/HCV infections and TP53 mutations in 49 of these HCC cases. HBV biomarkers were detected in 58.1% of the cases; HBV genotypes F and D were characterized in three of the samples. The HCV biomarker was detected in 37% of th

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Alhamadany, Alaa Younis Mahdy, and Wajdi Sabeeh Sadek. "Evaluation of the genotoxicity in patients with HBV, HCV, and HCC using micronucleus and comet assay in Mosul City\Iraq." International journal of health sciences 6, S1 (2022): 1567–79. http://dx.doi.org/10.53730/ijhs.v6ns1.4903.

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Hepatitis B virus (HBV) and hepatitis C virus (HCV) have mutagenic effects on somatic cells. HBV and HCV may be showing these mutagenic effects through its viral proteins or through integrating into host DNA. The aim of this study was to determine whether HBV and HCV have a genotoxic effect on the DNA of oral epithelial cells. A cohort of 145 samples have been collected from participants from the date of 5 \ 1 \ 2020 to 15\9\ 2021. Among those samples are (40 healthy controls, HBV 38, 44 HCV, and HCC 23) to make cytogenetic evaluation by observing the micronucleus (MNi) test and comet assay. F

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Shih, Yi-Fen, and Chun-Jen Liu. "Hepatitis C Virus and Hepatitis B Virus Co-Infection." Viruses 12, no. 7 (2020): 741. http://dx.doi.org/10.3390/v12070741.

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Hepatitis C virus (HCV) and hepatitis B virus (HBV) co-infection can be encountered in either virus endemic countries. Co-infection can also be found in populations at risk of parenteral transmission. Previous studies demonstrated a high risk of liver disease progression in patients with HCV/HBV co-infection; thus, they should be treated aggressively. Previous evidence recommended therapy combining peginterferon (pegIFN) alfa and ribavirin for co-infected patients with positive HCV RNA. Recent trials further advise using direct-acting antivirals (DAAs) for the clearance of HCV in the co-infect

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Haberl, Elisabeth M., Thomas S. Weiss, Georg Peschel, et al. "Liver Lipids of Patients with Hepatitis B and C and Associated Hepatocellular Carcinoma." International Journal of Molecular Sciences 22, no. 10 (2021): 5297. http://dx.doi.org/10.3390/ijms22105297.

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Hepatocellular carcinoma (HCC) still remains a difficult to cure malignancy. In recent years, the focus has shifted to lipid metabolism for the treatment of HCC. Very little is known about hepatitis B virus (HBV) and C virus (HCV)-related hepatic lipid disturbances in non-malignant and cancer tissues. The present study showed that triacylglycerol and cholesterol concentrations were similar in tumor adjacent HBV and HCV liver, and were not induced in the HCC tissues. Higher levels of free cholesterol, polyunsaturated phospholipids and diacylglycerol species were noted in non-tumorous HBV compar

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Alhamadany, Alaa Younis Mahdy, and Wajdi Sabeeh Sadek. "Evaluation of the genotoxicity and genomic instability in patients with HBV, HCV and HCC using micronucleus and comet assay." NTU Journal of Pure Sciences 1, no. 2 (2022): 54–63. http://dx.doi.org/10.56286/ntujps.v1i2.214.

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On somatic cells, the hepatitis B virus (HBV) and the hepatitis C virus (HCV) are mutagenic. HBV and HCV may be causing these mutagenesis effects via integrating into host DNA or by viral proteins. The purpose of this research was to investigate if HBV and HCV had a genotoxic effect on renal epithelial cells' DNA. A total of 145 samples were taken from participants between the periods of 5 \1 2020 and 15\9 2021. (40 healthy controls, HBV 38, 44 HCV, and HCC 23) were used to perform cytogenetic analysis in renal epithelial cells using the micronucleus (MNi) test and comet assay. For the comet e

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Kuo, Yuan-Hung, Tzu-Hsin Huang, Jing-Houng Wang, et al. "Well-Controlled Viremia Predicts the Outcome of Hepatocellular Carcinoma in Chronic Viral Hepatitis Patients Treated with Sorafenib." Cancers 14, no. 16 (2022): 3971. http://dx.doi.org/10.3390/cancers14163971.

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Without analyzing the status of viremia, hepatitis C virus-related hepatocellular carcinoma (HCV-HCC) patients are proposed to have better prognosis than hepatitis B virus-related HCC (HBV-HCC) patients using sorafenib. We aimed to elucidate the efficacy of concurrent sorafenib and anti-viral treatment for HCC patients with HBV or HCV infection in real world. Between January 2018 and January 2021, 256 unresectable HCC patients receiving first-line sorafenib were evaluated. High-potency nucleoside analogs were used for HBV control, whereas direct-acting antivirals were administered for HCV erad

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Jiang, Joy, Meredith S. Shiels, Donna Rivera, Marc G. Ghany, Eric A. Engels, and Thomas R. O’Brien. "Trends in hepatocellular carcinoma and viral hepatitis treatment in older Americans." PLOS ONE 19, no. 11 (2024): e0307746. http://dx.doi.org/10.1371/journal.pone.0307746.

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Background Incidence of hepatocellular carcinoma (HCC) had been increasing steadily among older Americans but plateaued in 2015–2017. Chronic infection with hepatitis B virus (HBV) or hepatitis C virus (HCV) are important causes of HCC. The impact of improved treatments for these infections on recent trends in HCC incidence is unclear. Aims To examine the relationship between use of antiviral therapy for chronic viral hepatis and HCC incidence in older Americans. Methods We used 2007–2017 data from the Surveillance, Epidemiology, and End Results—Medicare database to estimate age-standardized i

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Shrestha, Umid Kumar, and Bhup Dev Bhatta. "Seroprevalence of hepatitis B virus, hepatitis C virus and human immunodeficiency virus in the western region of Nepal." Journal of Advances in Internal Medicine 5, no. 1 (2017): 6–10. http://dx.doi.org/10.3126/jaim.v5i1.17064.

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Background and aims: The hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) are associated with major public health concerns. The aim of the study was to determine the seroprevalence of HBV, HCV and HIV in the western region of Nepal.Methods: This was a cross-sectional observational study, in which 15,791 patients, attending to Manipal Teaching Hospital, Pokhara, Nepal, were investigated for HBV, HCV and HIV from June 2013 to March 2016; demographic and biochemical profile were studied among the patients with positive test results.Results: Among 15,791 pati

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Samson, Adel, Matthew J. Bentham, Karen Scott, et al. "Oncolytic reovirus as a combined antiviral and anti-tumour agent for the treatment of liver cancer." Gut 67, no. 3 (2016): 562–73. http://dx.doi.org/10.1136/gutjnl-2016-312009.

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ObjectiveOncolytic viruses (OVs) represent promising, proinflammatory cancer treatments. Here, we explored whether OV-induced innate immune responses could simultaneously inhibit HCV while suppressing hepatocellular carcinoma (HCC). Furthermore, we extended this exemplar to other models of virus-associated cancer.Design and resultsClinical grade oncolytic orthoreovirus (Reo) elicited innate immune activation within primary human liver tissue in the absence of cytotoxicity and independently of viral genome replication. As well as achieving therapy in preclinical models of HCC through the activa

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Liu, Weibo. "The transmission route of hepatitis A, B, and C virus and its pathological changes on the liver." Theoretical and Natural Science 48, no. 1 (2024): 15–21. http://dx.doi.org/10.54254/2753-8818/48/2024pj0111.

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This study explored the globally prevalent pathogens, hepatitis viruses, and their significant impact on human health. This article mainly focuses on HAV, HBV, and HCV, aiming to provide a comprehensive reference for future studies. HAV is mainly transmitted through the gastrointestinal tract, while HBV and HCV are mainly transmitted through blood, body fluids, sexual contact, and mother-to-child transmission. Pathologically, HAV is mostly acute, while HBV and HCV tend to be chronic, which can easily lead to cirrhosis and even liver cancer. Analyzing the transmission mechanism and pathological

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Higgs, Martin R., Philippe Chouteau, and Hervé Lerat. "‘Liver let die’: oxidative DNA damage and hepatotropic viruses." Journal of General Virology 95, no. 5 (2014): 991–1004. http://dx.doi.org/10.1099/vir.0.059485-0.

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Chronic infections by the hepatotropic viruses hepatitis B virus (HBV) and hepatitis C virus (HCV) are major risk factors for the development of hepatocellular carcinoma (HCC). It is estimated that more than 700 000 individuals per year die from HCC, and around 80 % of HCC is attributable to HBV or HCV infection. Despite the clear clinical importance of virus-associated HCC, the underlying molecular mechanisms remain largely elusive. Oxidative stress, in particular DNA lesions associated with oxidative damage, play a major contributory role in carcinogenesis, and are strongly linked to the dev

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Awadh, Abdullah A., Abdulrahman A. Alharthi, Basil A. Alghamdi, et al. "Coinfection of Hepatitis B and C Viruses and Risk of Hepatocellular Carcinoma: Systematic Review and Meta-analysis." Journal of Global Infectious Diseases 16, no. 4 (2024): 127–34. https://doi.org/10.4103/jgid.jgid_211_23.

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Introduction: Hepatitis B and C are viral infections causing chronic liver inflammation and, when left untreated, lead to cirrhosis and a risk for hepatocellular carcinoma, the most common type of primary liver cancer with high mortality. The hepatitis B virus-hepatitis C virus (HBV-HCV) coinfection leads to a faster progression to advanced liver diseases and higher hepatocellular carcinoma (HCC) risk than monoinfection. Unlike the relative risk for HCC due to either HBV or HCV, no recent analysis of the risk for HBV-HCV coinfection exists. Methods: Based on PRISMA recommendations and guidelin

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Crobu, Maria Grazia, Paolo Ravanini, Clotilde Impaloni, et al. "Hepatitis C Virus as a Possible Helper Virus in Human Hepatitis Delta Virus Infection." Viruses 16, no. 6 (2024): 992. http://dx.doi.org/10.3390/v16060992.

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Previous studies reported that the hepatitis C virus (HCV) could help disseminate the hepatitis D virus (HDV) in vivo through the unrelated hepatitis B virus (HBV), but with essentially inconclusive results. To try to shed light on this still-debated topic, 146 anti-HCV-positive subjects (of whom 91 HCV/HIV co-infected, and 43 with prior HCV eradication) were screened for anti-HDV antibodies (anti-HD), after careful selection for negativity to any serologic or virologic marker of current or past HBV infection. One single HCV/HIV co-infected patient (0.7%) tested highly positive for anti-HD, bu

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Saitta, Carlo, Patrizia Pontisso, Maurizia R. Brunetto, et al. "Virological Profiles in Hepatitis B Virus/Hepatitis C Virus Coinfected Patients under Interferon plus Ribavirin Therapy." Antiviral Therapy 11, no. 7 (2006): 931–34. http://dx.doi.org/10.1177/135965350601100713.

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Background Hepatitis C virus (HCV) is believed to exert a suppressive effect on hepatitis B virus (HBV) in most HBV/HCV-coinfected patients; once HCV is cured by interferon-based therapy, these patients may show HBV reactivation. However, recent evidence revealed that the virological status in HBV/HCV-untreated individuals may vary over time and may show fluctuating profiles. Methods To evaluate the behaviour of apparently inactive HBV infection in patients under treatment for a concurrent HCV infection, we performed a prospective study that evaluated nine consecutive patients (eight males wit

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Cortes-Mancera, Fabian, Carmen Luisa Loureiro, Sergio Hoyos, et al. "Etiology and Viral Genotype in Patients with End-Stage Liver Diseases admitted to a Hepatology Unit in Colombia." Hepatitis Research and Treatment 2011 (September 20, 2011): 1–10. http://dx.doi.org/10.1155/2011/363205.

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Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are the principal risk factor associated to end-stage liver diseases in the world. A study was carried out on end-stage liver disease cases admitted to an important hepatology unit in Medellin, the second largest city in Colombia. From 131 patients recruited in this prospective study, 71% of cases were diagnosed as cirrhosis, 12.2% as HCC, and 16.8% as cirrhosis and HCC. Regarding the risk factors of these patients, alcohol consumption was the most frequent (37.4%), followed by viral etiology (17.6%). Blood and/or hepatic tissue sa

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Khandekar, Rahul, Sabi Shrestha, Kawika Dipko, Colleen Conger, and Neil B. Newman. "Viral-Mediated Hepatocellular Carcinoma: A Review on Mechanisms and Implications for Therapy." Applied Radiation Oncology 13, no. 3 (2024): 15–22. https://doi.org/10.37549/aro-d-24-00019.

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Abstract Hepatocellular carcinoma (HCC) is one of the most common cancers in the United States. Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are major risk factors of HCC. This review article discusses the pathogenesis behind HBV- and HCV-induced HCC, examining the ways these viruses contribute to the development of liver cancer. Furthermore, we aim to explore the therapeutic implications of viral-mediated HCC, with an interest in preventing chronic infections and subsequent HCC development. By understanding the underlying pathogenesis and therapeutic targets, we aim

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Lin, Ping-Yi, Shu-Chu Chen, Tsai-Chang Lo, and Hsien-Wen Kuo. "Dual Infection with Hepatitis B Virus and Hepatitis C Virus Correlated with Type 2 Diabetes Mellitus." Experimental and Clinical Endocrinology & Diabetes 128, no. 01 (2019): 38–42. http://dx.doi.org/10.1055/a-0794-6135.

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Abstract Background Conflicting data exist regarding the relationship between dual infection of hepatitis B virus (HBV) and hepatitis C virus (HCV) with type 2 diabetes mellitus (T2DM). We assessed dual infection of HBV and HCV with the levels of blood glucose and development of DM. Methods A total of 9621 participants in a community-based study were enrolled from 18 towns in Maoli county of Taiwan. Blood samples were collected and tested for hepatitis B surface antigen (HBsAg) and antibodies (HBsAb), antibodies against hepatitis C virus (anti-HCV) and fasting plasma glucose. DM was defined as

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Ullah, Qudrat, Usman Ali Rehman, Asif Hanif, and Sami Ullah Bhatti. "Frequency of Parenteral Exposure and Seroprevalence of HBV, HCV and HIV among Operating Room Personnel." International Journal of Frontier Sciences 2, no. 2 (2018): 3–10. https://doi.org/10.5281/zenodo.2545981.

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Abstract Background: There are many experiences in the operation theatre professionals to get Hepatitis B virus, Hepatitis C virus and Human immunodeficiency virus during their profession in operating room due to accidental needle pricks or through cut by any sharp. The objective of this study is to find out the Frequency of parenteral exposure and seroprevalence of HBV, HCV and HIV among operating room personnel. Methodology: Frequency of parenteral exposure and seroprevalence of HBV, HCV and HIV among operating room personnel was found using ICT method. Results: All 108 (100 %) operating roo

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Kanda, Tatsuo, Taichiro Goto, Yosuke Hirotsu, Mitsuhiko Moriyama, and Masao Omata. "Molecular Mechanisms Driving Progression of Liver Cirrhosis towards Hepatocellular Carcinoma in Chronic Hepatitis B and C Infections: A Review." International Journal of Molecular Sciences 20, no. 6 (2019): 1358. http://dx.doi.org/10.3390/ijms20061358.

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Almost all patients with hepatocellular carcinoma (HCC), a major type of primary liver cancer, also have liver cirrhosis, the severity of which hampers effective treatment for HCC despite recent progress in the efficacy of anticancer drugs for advanced stages of HCC. Here, we review recent knowledge concerning the molecular mechanisms of liver cirrhosis and its progression to HCC from genetic and epigenomic points of view. Because ~70% of patients with HCC have hepatitis B virus (HBV) and/or hepatitis C virus (HCV) infection, we focused on HBV- and HCV-associated HCC. The literature suggests t

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Gonçales, Fernando Lopes, Josiane Silveira Felix Pereira, Claudia da Silva, et al. "Hepatitis B Virus DNA in Sera of Blood Donors and of Patients Infected with Hepatitis C Virus and Human Immunodeficiency Virus." Clinical Diagnostic Laboratory Immunology 10, no. 4 (2003): 718–20. http://dx.doi.org/10.1128/cdli.10.4.718-720.2003.

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ABSTRACT With the use of PCR, we searched for hepatitis B virus (HBV) DNA in serum samples from 415 HBsAg-negative, anti-HBc-positive patients: 150 were blood donors, 106 had only hepatitis C virus (HCV) infection, and 159 had human immunodeficiency virus (HIV) infection (of which 88 were HCV positive and 71 were HCV negative). HBV DNA was detected in 4% of blood donors, 3.4% of HIV- and HCV-positive patients, and 24% of HCV-positive patients.

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Afsheen Qazi, Bhawani Shanker, Rajesh Rathi, and Narindar Kumar. "Seroprevalence of Hepatitis-B virus and Hepatitis-C virus in pregnant women in Hyderabad." JMMC 10, no. 2 (2020): 59–61. http://dx.doi.org/10.62118/jmmc.v10i2.110.

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Introduction: Infections of the hepatitis B virus (HBV) and the hepatitis C virus (HCV) are major global public health problem. Approximately 350 million and 190 million people worldwide are infected with HBV and HCV respectively.  Objective: To evaluate seroprevalence of hepatitis B and C among pregnant women of Hyderabad. Methodology: This prospective cross sectional study conducted at Pathology department of a tertiary care hospital of Hyderabad during Jan 2019 to July 2019. During period of study data of 500 pregnant women recorded on pre structured proforma after taking inform

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Hester, Caitlin A., Nicole E. Rich, Amit G. Singal, and Adam C. Yopp. "Comparative Analysis of Nonalcoholic Steatohepatitis– Versus Viral Hepatitis– and Alcohol-Related Liver Disease–Related Hepatocellular Carcinoma." Journal of the National Comprehensive Cancer Network 17, no. 4 (2019): 322–29. http://dx.doi.org/10.6004/jnccn.2018.7105.

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Background: Despite an increasing burden of nonalcoholic steatohepatitis (NASH), limited data are available comparing outcomes of NASH-related hepatocellular carcinoma (HCC) versus other etiologies. Methods: Patient demographic and tumor characteristics were collected for 1,051 patients diagnosed with NASH-, alcohol-related liver disease (ALD)–, hepatitis C virus (HCV)–, and hepatitis B virus (HBV)–related HCC at 2 large health systems from January 2008 through December 2016. Patient demographics, clinical characteristics, and survival were compared. Risk-adjusted treatment receipt and overall

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Mbaga, Donatien Serge, Sebastien Kenmoe, Cyprien Kengne-Ndé, et al. "Hepatitis B, C and D virus infections and risk of hepatocellular carcinoma in Africa: A meta-analysis including sensitivity analyses for studies comparable for confounders." PLOS ONE 17, no. 1 (2022): e0262903. http://dx.doi.org/10.1371/journal.pone.0262903.

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Introduction Africa denotes unique facies for hepatocellular carcinoma (HCC) characterized by a conjunction of low sensitization, restricted access to diagnosis and treatment and associated with the highest incidence and mortality in the world. We investigated whether hepatitis B (HBV), C (HCV) and D (VHD) viruses were etiological agents of HCC in Africa. Methods Relevant articles were searched in PubMed, Web of Science, African Index Medicus, and African Journal Online databases, as well as manual searches in relevant reviews and included articles. Analytical studies from Africa evaluating th

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Szalay, Ferenc. "Hepatitis C virus infection and hepatocarcinogenesis." Orvosi Hetilap 151, no. 38 (2010): 1524–29. http://dx.doi.org/10.1556/oh.2010.28946.

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Ma már bizonyított, hogy nemcsak a HBV-, hanem a HCV-infekció is krónikus hepatitist, májcirrhosist és hepatocellularis májrákot (HCC) okozhat. A hepatitis C-vírus is onkogén vírusnak minősül. A két különböző vírus által indukált májrák kialakulásának mechanizmusa több közös és számos eltérő sajátságot mutat. Mindkét esetben többnyire hosszú évekig, akár évtizedekig tartó krónikus gyulladás által okozott májcirrhosis talaján alakul ki a májrák. A HCV mint RNS-vírus nem épül be a májsejt genomjába, hanem különböző utakon indukálja a ráksejtek kialakulását, amelyek azután kontroll nélkül prolife

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Sethi, Amna Ameen, and Nisar Ahmed Shar. "Molecular insights into the viral etiologies in liver cancer." Pakistan Journal of Science 76, no. 04 (2024): 522–29. https://doi.org/10.57041/vol76iss04pp522-529.

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Hepatitis B (HBV) and Hepatitis C (HCV) viruses are the main causes of viral hepatitis, which greatly increases the incidence of liver cancer worldwide, especially hepatocellular carcinoma (HCC). The infections caused by HBV and HCV can progress from acute to chronic stages, with an increased risk for HCC due to the promotion of cirrhosis. Therefore, it is essential to understand the molecular mechanisms of HBV and HCV attachment, and entry into human cells for developing targeted therapies and preventive measures. This study identifies and analyzes the functional receptors involved in HBV and

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Yen, Yi-Hao, Kwong-Ming Kee, Wei-Feng Li, et al. "Causes of Death among Patients with Hepatocellular Carcinoma According to Chronic Liver Disease Etiology." Cancers 15, no. 6 (2023): 1687. http://dx.doi.org/10.3390/cancers15061687.

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This study was conducted to determine whether the causes of death among patients with hepatocellular carcinoma (HCC) differ according to chronic liver disease (CLD) etiology. Between 2011 and 2020, 3977 patients who were newly diagnosed with HCC at our institution were enrolled in this study. We determined whether the cause of death was HCC-related and non-HCC-related. For patients with multiple CLD etiologies, etiology was classified using the following hierarchy: hepatitis C virus (HCV) > hepatitis B virus (HBV) > alcohol-related causes > all negative. All negative was defined as ne

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Tong, C. Y. W., R. Khan, N. J. Beeching, et al. "The occurrence of hepatitis B and C viruses in Pakistani patients with chronic liver disease and hepatocellula carcinoma." Epidemiology and Infection 117, no. 2 (1996): 327–32. http://dx.doi.org/10.1017/s0950268800001503.

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SummaryTo study the occurrence of hepatitis B virus (HBV) and hepatitis C virus (HCV) in patients with chronic liver disease (CLD) and hepatocellular carcinoma (HCC) in Pakistan, blood samples from 105 sequential patients with biopsy-proven CLD (n= 82) and HCC (n= 23) were tested for HBV and HCV markers. Of the 105, 87 (83%) had evidence of hepatitis B exposure, 58 (55%) were positive for hepatitis B surface antigen (HBsAg), 23 (22%) had hepatitis C antibodies and 25 (24%) had detectable HCV RNA. Significantly more patients with HCC had evidence of HBV exposure in the absence of HCV markers (4

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Castillo, Inmaculada, Javier Bartolomé, Juan Antonio Quiroga, and Vicente Carreño. "High prevalence of occult hepatitis C virus infection in patients with chronic hepatitis B virus infection." Journal of Medical Microbiology 62, no. 8 (2013): 1235–38. http://dx.doi.org/10.1099/jmm.0.058297-0.

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Hepatitis C virus (HCV) infection in the absence of detectable antibodies against HCV and of viral RNA in serum is called occult HCV infection. Its prevalence and clinical significance in chronic hepatitis B virus (HBV) infection is unknown. HCV RNA was tested for in the liver samples of 52 patients with chronic HBV infection and 21 (40 %) of them were positive for viral RNA (occult HCV infection). Liver fibrosis was found more frequently and the fibrosis score was significantly higher in patients with occult HCV than in negative ones, suggesting that occult HCV infection may have an impact on

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Yaro, Abubakar, Svetoslav Martinov, and Catherine Johnson. "Efficacy of combined antiretroviral therapy (cART) in Hepatitis B and C associated hepatocellular carcinoma (HCC): a narrative review." Journal of Human Virology & Retrovirology 10, no. 3 (2023): 73–78. http://dx.doi.org/10.15406/jhvrv.2023.10.00271.

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Introduction: HCC is the 3rd leading cancers in the world. Majority of HCC are due to chronic viral hepatitis including HBV, HCV, and HDV. Progression to cirrhosis and HCC in HBV and HCV infection is linked to level of replication and high serum viral DNA load. The use of antiviral agents is an effective strategy of treating HBV- and HCV- associated HCC. Aim: To assess the effectiveness of combined antiretroviral therapy on HBV and HCV-associated HCC Method: A narrative review of literature involving RCT and observational studies was performed. Blinding scores was used to evaluate the quality

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Adeiza, Shuaibu Suleiman, Md Aminul Islam, Hauwa’u Umar Mungadi, Abdulmalik Bello Shuaibu, and Ranjit Sah. "A preregistered meta-meta-analysis on the global distribution of Hepatotropic Viruses." Problems of Virology 69, no. 5 (2024): 429–40. http://dx.doi.org/10.36233/0507-4088-234.

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Introduction. Hepatotropic viruses (HAV, HBV, HCV, HDV, and HEV) significantly impact global health, with varying prevalence across regions. Objective. This study aims to systematically consolidate data from diverse meta-analyses to provide a contemporary reference on virus distribution and prevalence. Materials and methods. Adhering to PRISMA guidelines, the study utilized a mixed effects model for data integration. Quality evaluation was carried out with QUOROM and AMSTAR tools, with heterogeneity assessed via the Higgins I2 statistic, Q-statistic and Tau squared (τ2) values. Results. The st

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von Drygalski, Annette, Niamh O'Connell, Peter Verhamme, et al. "Adult Patients with Hemophilia B and with a History of Chronic HCV/HBV Infection Receiving Liver-Directed Gene Therapy Demonstrated Long-Term Bleeding Protection and Sustained FIX Activity: Efficacy and Safety Results from the HOPE-B Trial 3 Years after Administration of a Single Dose of Etranacogene Dezaparvovec." Blood 142, Supplement 1 (2023): 2258. http://dx.doi.org/10.1182/blood-2023-188921.

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Introduction: Liver-targeted recombinant adeno-associated virus (rAAV) gene therapy for hemophilia B has recently become a real-world therapeutic option for an adult population burdened with prevalent co-morbid chronic hepatitis C virus (HCV) and hepatitis B virus (HBV). The pivotal phase 3 HOPE-B trial (NCT03489291) evaluated the efficacy and safety of etranacogene dezaparvovec (CSL222, formerly AMT-061), an AAV5 vector, containing a codon-optimized, highly active factor IX (FIX) Padua R338L transgene under the control of the liver-specific promoter LP-1. Here we evaluate the efficacy and saf

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Alshimerry, Athraa Falah, and Rawaa Ghalib Farhood. "Concept of HBV and HCV as a risk factor and prevention of viral hepatitis-related hepatocellular carcinoma." Medical Journal of Babylon 20, no. 4 (2023): 657–60. http://dx.doi.org/10.4103/mjbl.mjbl_269_23.

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Abstract Hepatocellular carcinoma (HCC) represents one of the most common cancers worldwide, and it is a very important reason for cancer-related death. Infection with hepatitis B virus (HBV) and hepatitis C virus (HCV) is considered the major leading cause of HCC. The pathophysiology of HB and HC viral-related HCC includes chronic inflammation, deorganization of cell signaling pathways, and oxidative stress. Contrary to HCV, HBV is oncogenic by itself, due to its integration into the DNA of cell. Six months of ultrasound monitoring is recommended for high-risk patients. Using antiviral drugs

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Kaliaskarova, Kulpash. "Aspects of Cancer Prevention of the Main Precursors of Liver Carcinoma - Viral hepatitis." Oncology.kz, no. 8 (August 15, 2023): 13–17. https://doi.org/10.56598/2957-6377-2023-8-13-17.

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The vast majority of hepatocellular carcinoma (HCC) tumors arise from liver cirrhosis (LC), which in turn is most often caused by infection with hepatitis B virus (HBV) or hepatitis C virus (HCV).The purpose of the study: to assess the dynamics of the prevalence of HBV and HCV as one of the factors in the development of cirrhosis and HCC.Methods. A retrospective analysis of the prevalence of HBV, HCV, LC and HCC over a 10-year period (2013-2022) was carried out. The dynamics of the incidence of HCV and HBV infections from 2020 to 2022 was also studied. The work used data from the Information S

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Huang, Xiao-wen, Bing Liao, Yang Huang, et al. "Non-Invasive Diagnostic Criteria for Hepatocellular Carcinoma in Hepatitis B Virus-Endemic Areas: Is Cirrhosis Indispensable?" Digestive Diseases 36, no. 3 (2018): 228–35. http://dx.doi.org/10.1159/000486196.

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Aim: To confirm whether cirrhosis is indispensable for the non-invasive diagnostic criteria for hepatocellular carcinoma (HCC) in hepatitis B virus (HBV)-endemic areas. Methods: Between January 2014 and December 2014, a total of 409 patients with pathologically proven focal liver lesions who underwent contrast-enhanced ultrasound (CEUS) were recruited from our institution. Clinical liver cirrhosis, HBV/HCV infection and HCC-typical vascular pattern of the targeted lesion on CEUS were evaluated. The following 3 criteria were applied to these patients to diagnose HCC: criterion 1, clinical liver

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Yan, Brian M., and Samuel S. Lee. "Acute Coinfection with Hepatitis B and Hepatitis C Viruses." Canadian Journal of Gastroenterology 19, no. 12 (2005): 729–30. http://dx.doi.org/10.1155/2005/514813.

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Acute coinfection of hepatitis B virus (HBV) and hepatitis C virus (HCV) is rare. The few previously reported cases all describe acute HBV followed by acute HCV, leading to HBV clearance but chronic HCV. This is the first reported case of acute concurrent infection and spontaneous clearance of both HBV and HCV.

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Kishta, Sara, Ashraf Tabll, Tea Omanovic Kolaric, Robert Smolic, and Martina Smolic. "Risk Factors Contributing to the Occurrence and Recurrence of Hepatocellular Carcinoma in Hepatitis C Virus Patients Treated with Direct-Acting Antivirals." Biomedicines 8, no. 6 (2020): 175. http://dx.doi.org/10.3390/biomedicines8060175.

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Although hepatitis C virus (HCV) RNA may be eliminated from blood circulation by direct-acting antivirals (DAA) therapy as assessed by real-time polymerase chain reaction (PCR), HCV RNA can still be present in liver tissue, and this is known as occult HCV. There has been a lot of controversy surrounding the recurrence of hepatocellular carcinoma (HCC) after DAA treatment of hepatic cells infected with chronic HCV. One of the main risk factors that leads to de novo HCC is the chronicity of HCV in hepatic cells. There are many studies regarding the progression of HCV-infected hepatic cells to HC

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Gurung, Kishor, T. P. Poudel, G. J. Shah, and D. Mishra. "Seroprevalence of Human Immunodeficiency Virus, Hepatitis B Virus and Hepatitis C Virus in Nepalgunj Medical College, Nepal." Journal of Nepalgunj Medical College 16, no. 1 (2018): 63–66. http://dx.doi.org/10.3126/jngmc.v16i1.24233.

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Introduction: Human immune deficiency viruses (HIV), Hepatitis B viruses (HBV) and Hepatitis C viruses (HCV) are the three most common chronic viral pathogens known. The viruses have common routes of transmission (such as blood and blood products, sharing needles to inject drugs and sexual activities) and similar risk factors. Aim and objective: The aim of study was to determine the seroprevalence of HIV, HBV and HCV in Kohalpur Teaching Hospital, Nepalgunj Medical College. Materials and methods: This is a descriptive hospital based study. The study was conducted at Nepalgunj Medic

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Brackmann, SA, A. Gerritzen, J. Oldenburg, HH Brackmann, and KE Schneweis. "Search for intrafamilial transmission of hepatitis C virus in hemophilia patients." Blood 81, no. 4 (1993): 1077–82. http://dx.doi.org/10.1182/blood.v81.4.1077.1077.

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Abstract This study was performed to determine the risk of family members of anti-hepatitis C virus (HCV)-positive hemophilia patients (index patients) for infection with HCV compared with the risk of acquiring hepatitis B virus (HBV), human immunodeficiency virus (HIV), and hepatitis A virus (HAV) infection. All index patients (n = 141) were found to be positive by first and second generation anti-HCV enzyme immunoassays (EIAs). Among their household contacts (n = 228), 224 were negative and 1 positive by both assays. Three contacts gave positive results in first generation anti-HCV EIA and n

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Brackmann, SA, A. Gerritzen, J. Oldenburg, HH Brackmann, and KE Schneweis. "Search for intrafamilial transmission of hepatitis C virus in hemophilia patients." Blood 81, no. 4 (1993): 1077–82. http://dx.doi.org/10.1182/blood.v81.4.1077.bloodjournal8141077.

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This study was performed to determine the risk of family members of anti-hepatitis C virus (HCV)-positive hemophilia patients (index patients) for infection with HCV compared with the risk of acquiring hepatitis B virus (HBV), human immunodeficiency virus (HIV), and hepatitis A virus (HAV) infection. All index patients (n = 141) were found to be positive by first and second generation anti-HCV enzyme immunoassays (EIAs). Among their household contacts (n = 228), 224 were negative and 1 positive by both assays. Three contacts gave positive results in first generation anti-HCV EIA and negative r

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50

Andressa de Farias Fehlberg, Joelma Lessa da Silva, Roberta Pinho Gomes, and Rachel Siqueira de Queiroz Simões. "Immunological serum markers for hepatitis viral infections: HAV, HBV, HCV to advance of genetic engineering." GSC Biological and Pharmaceutical Sciences 25, no. 1 (2023): 118–30. http://dx.doi.org/10.30574/gscbps.2023.25.1.0394.

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Viral hepatitis is increasingly present in infections diagnosed around the world. Thousands of individuals are infected by these often-silent diseases that only manifest themselves when clinical signs are very advanced. Hepatitis A virus (HAV) is a vaccine-preventable liver infection. Recombinant vaccines had been applied with the advance of genetic engineering for HBV. New studies have investigated the improvement of the vaccine model of heterological antigens based on hepatitis B virus envelope protein containing HCV antigen as a chimeric vaccine. The aim of this study was to evaluate the de

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