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Journal articles on the topic 'Hematopoiesis Regulation'

Author: Grafiati

Published: 4 June 2021

Last updated: 29 January 2023

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1

Nathan, David G. "Regulation of Hematopoiesis." Pediatric Research 27, no. 5 (May 1990): 423–31. http://dx.doi.org/10.1203/00006450-199005000-00001.

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2

Li, Haiyan, Jin Jin, shao-Cong Sun, and Stephanie S. Watowich. "Molecular Regulation of Adult Hematopoiesis By GATA-2." Blood 124, no. 21 (December 6, 2014): 4337. http://dx.doi.org/10.1182/blood.v124.21.4337.4337.

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Abstract GATA-2 is a zinc finger-containing transcriptional regulator that plays important roles in embryonic and adult hematopoiesis. Mutations in human GATA2 are associated with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), as well as immunodeficiency disorders that present with a profound loss of monocytes, dendritic cells and other myeloid lineage populations. Recent work reveals crucial roles for GATA-2 in definitive hematopoietic stem/progenitor cell activity, vascular integrity and lymphatic development. However, the molecular mechanisms by which GATA-2 controls adult

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3

Zon, LI. "Developmental biology of hematopoiesis." Blood 86, no. 8 (October 15, 1995): 2876–91. http://dx.doi.org/10.1182/blood.v86.8.2876.bloodjournal8682876.

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The cellular and environmental regulation of hematopoiesis has been generally conserved throughout vertebrate evolution, although subtle species differences exist. The factors that regulate hematopoietic stem cell homeostasis may closely resemble the inducers of embryonic patterning, rather than the factors that stimulate hematopoietic cell proliferation and differentiation. Comparative study of embryonic hematopoiesis in lower vertebrates can generate testable hypotheses that similar mechanisms occur during hematopoiesis in higher species.

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Zon, LI. "Developmental biology of hematopoiesis." Blood 86, no. 8 (October 15, 1995): 2876–91. http://dx.doi.org/10.1182/blood.v86.8.2876.2876.

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Abstract The cellular and environmental regulation of hematopoiesis has been generally conserved throughout vertebrate evolution, although subtle species differences exist. The factors that regulate hematopoietic stem cell homeostasis may closely resemble the inducers of embryonic patterning, rather than the factors that stimulate hematopoietic cell proliferation and differentiation. Comparative study of embryonic hematopoiesis in lower vertebrates can generate testable hypotheses that similar mechanisms occur during hematopoiesis in higher species.

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de Rooij, Laura P. M. H., Derek C. H. Chan, Ava Keyvani Chahi, and Kristin J. Hope. "Post-transcriptional regulation in hematopoiesis: RNA binding proteins take control." Biochemistry and Cell Biology 97, no. 1 (February 2019): 10–20. http://dx.doi.org/10.1139/bcb-2017-0310.

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Normal hematopoiesis is sustained through a carefully orchestrated balance between hematopoietic stem cell (HSC) self-renewal and differentiation. The functional importance of this axis is underscored by the severity of disease phenotypes initiated by abnormal HSC function, including myelodysplastic syndromes and hematopoietic malignancies. Major advances in the understanding of transcriptional regulation of primitive hematopoietic cells have been achieved; however, the post-transcriptional regulatory layer that may impinge on their behavior remains underexplored by comparison. Key players at

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Chen, Sisi, and Omar Abdel-Wahab. "Splicing regulation in hematopoiesis." Current Opinion in Hematology 28, no. 4 (May 10, 2021): 277–83. http://dx.doi.org/10.1097/moh.0000000000000661.

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7

QUESENBERRY, PETER J., IAN K. MCNIECE, H. ELIZABETH MCGRATH, DANIEL S. TEMELES, GWEN B. BABER, and DONNA H. DEACON. "Stromal Regulation of Hematopoiesis." Annals of the New York Academy of Sciences 554, no. 1 Molecular and (May 1989): 116–24. http://dx.doi.org/10.1111/j.1749-6632.1989.tb22414.x.

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8

Sashida, Goro, and Atsushi Iwama. "Epigenetic regulation of hematopoiesis." International Journal of Hematology 96, no. 4 (September 29, 2012): 405–12. http://dx.doi.org/10.1007/s12185-012-1183-x.

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9

North, Trista. "Regulation of vertebrate hematopoiesis." Experimental Hematology 53 (September 2017): S40. http://dx.doi.org/10.1016/j.exphem.2017.06.042.

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10

Wimmer, Antonia, Sophia K. Khaldoyanidi, Martin Judex, Naira Serobyan, Richard G. DiScipio, and Ingrid U. Schraufstatter. "CCL18/PARC stimulates hematopoiesis in long-term bone marrow cultures indirectly through its effect on monocytes." Blood 108, no. 12 (December 1, 2006): 3722–29. http://dx.doi.org/10.1182/blood-2006-04-014399.

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AbstractChemokines play a role in regulating hematopoietic stem cell function, including migration, proliferation, and retention. We investigated the involvement of CCL18 in the regulation of bone marrow hematopoiesis. Treatment of human long-term bone marrow cultures (LTBMCs) with CCL18 resulted in significant stimulation of hematopoiesis, as measured by the total number of hematopoietic cells and their committed progenitors produced in culture. Monocytes/macrophages, whose survival was almost doubled in the presence of CCL18 compared with controls, were the primary cells mediating this effec

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11

Sood, Raman, and Paul Liu. "Novel Insights into the Genetic Controls of Primitive and Definitive Hematopoiesis from Zebrafish Models." Advances in Hematology 2012 (2012): 1–13. http://dx.doi.org/10.1155/2012/830703.

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Hematopoiesis is a dynamic process where initiation and maintenance of hematopoietic stem cells, as well as their differentiation into erythroid, myeloid and lymphoid lineages, are tightly regulated by a network of transcription factors. Understanding the genetic controls of hematopoiesis is crucial as perturbations in hematopoiesis lead to diseases such as anemia, thrombocytopenia, or cancers, including leukemias and lymphomas. Animal models, particularly conventional and conditional knockout mice, have played major roles in our understanding of the genetic controls of hematopoiesis. However,

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12

Davis, Amanda G., Jaclyn M. Einstein, Dinghai Zheng, Nathan D. Jayne, Xiang-Dong Fu, Bin Tian, Gene W. Yeo, and Dong-Er Zhang. "A CRISPR RNA-binding protein screen reveals regulators of RUNX1 isoform generation." Blood Advances 5, no. 5 (March 3, 2021): 1310–23. http://dx.doi.org/10.1182/bloodadvances.2020002090.

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Abstract The proper balance of hematopoietic stem cell (HSC) self-renewal and differentiation is critical for normal hematopoiesis and is disrupted in hematologic malignancy. Among regulators of HSC fate, transcription factors have a well-defined central role, and mutations promote malignant transformation. More recently, studies have illuminated the importance of posttranscriptional regulation by RNA-binding proteins (RBPs) in hematopoiesis and leukemia development. However, the RBPs involved and the breadth of regulation are only beginning to be elucidated. Furthermore, the intersection betw

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13

Fielding, Claire, and Simón Méndez-Ferrer. "Neuronal regulation of bone marrow stem cell niches." F1000Research 9 (June 16, 2020): 614. http://dx.doi.org/10.12688/f1000research.22554.1.

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The bone marrow (BM) is the primary site of postnatal hematopoiesis and hematopoietic stem cell (HSC) maintenance. The BM HSC niche is an essential microenvironment which evolves and responds to the physiological demands of HSCs. It is responsible for orchestrating the fate of HSCs and tightly regulates the processes that occur in the BM, including self-renewal, quiescence, engraftment, and lineage differentiation. However, the BM HSC niche is disturbed following hematological stress such as hematological malignancies, ionizing radiation, and chemotherapy, causing the cellular composition to a

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14

Kotsianidis, Ioannis, Jonathan D. Silk, Scott Patterson, Antonio Almeida, Costas Tsatalas, George Bourikas, Vincenzo Cerundolo, Irene A. G. Roberts, and Anastasios Karadimitris. "Regulation of Hematopoiesis In Vitro and In Vivo by Invariant NKT Cells." Blood 106, no. 11 (November 16, 2005): 2277. http://dx.doi.org/10.1182/blood.v106.11.2277.2277.

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Abstract Invariant NKT cells (iNKT cells) are a small subset of immunoregulatory T cells highly conserved in humans and mice. Upon activation by glycolipids presented by the MHC-like molecule CD1d, iNKT cells promptly secrete Th1/2 cytokines but also cytokines with hematopoietic potential such as IL-3 and GM-CSF. In mice, NKT cells activated by alpha-galactosylceramide (alphaGC), a potent glycolipid ligand, cause an in increase in extramedullary hematopoietic committed progenitor activity through secretion of these cytokines. We tested the role of iNKT cells in regulating hematopoiesis under c

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15

Uckun, F. M., D. A. Vallera, and S. L. Wee. "B lymphocyte regulation of human hematopoiesis." Journal of Immunology 135, no. 6 (December 1, 1985): 3817–22. http://dx.doi.org/10.4049/jimmunol.135.6.3817.

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Abstract Epstein Barr virus (EBV)-transformed B lymphoblastoid cell lines (BLCL) were derived from seven different individuals. The ability of BLCL supernatants to stimulate hematopoietic colony formation in vitro was tested in a conventional stem cell assay system. Supernatants promoted the growth of single (GM, E, MK) as well as multi-lineage (GEMM) colonies in bone marrow cultures. Our results indicate that EBV-transformed B lymphocytes produce cytokines that affect in vitro stem cell proliferation and differentiation. These studies demonstrate the regulatory potential of activated B lympho

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16

Takizawa, Hitoshi, Steffen Boettcher, and Markus G. Manz. "Demand-adapted regulation of early hematopoiesis in infection and inflammation." Blood 119, no. 13 (March 29, 2012): 2991–3002. http://dx.doi.org/10.1182/blood-2011-12-380113.

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AbstractDuring systemic infection and inflammation, immune effector cells are in high demand and are rapidly consumed at sites of need. Although adaptive immune cells have high proliferative potential, innate immune cells are mostly postmitotic and need to be replenished from bone marrow (BM) hematopoietic stem and progenitor cells. We here review how early hematopoiesis has been shaped to deliver efficient responses to increased need. On the basis of most recent findings, we develop an integrated view of how cytokines, chemokines, as well as conserved pathogen structures, are sensed, leading

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17

Remillieux-Leschelle, Nathalie, Pedro Santamaria, and Neel B. Randsholt. "Regulation of Larval Hematopoiesis in Drosophila melanogaster: A Role for the multi sex combs Gene." Genetics 162, no. 3 (November 1, 2002): 1259–74. http://dx.doi.org/10.1093/genetics/162.3.1259.

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Abstract Drosophila larval hematopoietic organs produce circulating hemocytes that ensure the cellular host defense by recognizing and neutralizing non-self or noxious objects through phagocytosis or encapsulation and melanization. Hematopoietic lineage specification as well as blood cell proliferation and differentiation are tightly controlled. Mutations in genes that regulate lymph gland cell proliferation and hemocyte numbers in the body cavity cause hematopoietic organ overgrowth and hemocyte overproliferation. Occasionally, mutant hemocytes invade self-tissues, behaving like neoplastic ma

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18

Jenkins, Brendan J., Andrew W. Roberts, Meri Najdovska, Dianne Grail, and Matthias Ernst. "The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis." Blood 105, no. 9 (May 1, 2005): 3512–20. http://dx.doi.org/10.1182/blood-2004-09-3751.

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Abstract The interleukin-6 (IL-6) cytokine family plays an important role in regulating cellular responses during hematopoiesis. We report here that mice homozygous for a knock-in mutation in the IL-6 cytokine family receptor signaling subunit glycoprotein (gp) 130 (gp130Y757F/Y757F) that leads to gp130-dependent signal transducers and activators of transcription (STAT) 1/3 hyperactivation develop a broad spectrum of hematopoietic abnormalities, including splenomegaly, lymphadenopathy, and thrombocytosis. To determine whether STAT3 hyperactivation was responsible for the perturbed hematopoiesi

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19

Orelio, Claudia, Esther Haak, Marian Peeters, and Elaine Dzierzak. "Interleukin-1–mediated hematopoietic cell regulation in the aorta-gonad-mesonephros region of the mouse embryo." Blood 112, no. 13 (December 15, 2008): 4895–904. http://dx.doi.org/10.1182/blood-2007-12-123836.

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Abstract Hematopoiesis during development is a dynamic process, with many factors involved in the emergence and regulation of hematopoietic stem cells (HSCs) and progenitor cells. Whereas previous studies have focused on developmental signaling and transcription factors in embryonic hematopoiesis, the role of well-known adult hematopoietic cytokines in the embryonic hematopoietic system has been largely unexplored. The cytokine interleukin-1 (IL-1), best known for its proinflammatory properties, has radioprotective effects on adult bone marrow HSCs, induces HSC mobilization, and increases HSC

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20

Kotsianidis, Ioannis, Jonathan D. Silk, Emmanouil Spanoudakis, Scott Patterson, Antonio Almeida, Richard R. Schmidt, Costas Tsatalas, et al. "Regulation of hematopoiesis in vitro and in vivo by invariant NKT cells." Blood 107, no. 8 (April 15, 2006): 3138–44. http://dx.doi.org/10.1182/blood-2005-07-2804.

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AbstractInvariant natural killer T cells (iNKT cells) are a small subset of immunoregulatory T cells highly conserved in humans and mice. On activation by glycolipids presented by the MHC-like molecule CD1d, iNKT cells promptly secrete T helper 1 and 2 (Th1/2) cytokines but also cytokines with hematopoietic potential such as GM-CSF. Here, we show that the myeloid clonogenic potential of human hematopoietic progenitors is increased in the presence of glycolipid-activated, GM-CSF–secreting NKT cells; conversely, short- and long-term progenitor activity is decreased in the absence of NKT cells, i

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21

Liu, Ying, Khalid Timani, Charlie Mantel, Yan Fan, Giao Hangoc, Scott Cooper, Johnny J. He, and Hal E. Broxmeyer. "TIP110/p110nrb/SART3/p110 regulation of hematopoiesis through CMYC." Blood 117, no. 21 (May 26, 2011): 5643–51. http://dx.doi.org/10.1182/blood-2010-12-325332.

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Abstract Intracellular factors are involved in and essential for hematopoiesis. HIV-1 Tat-interacting protein of 110 kDa (TIP110; p110nrb/SART3/p110) is an RNA-binding nuclear protein implicated in the regulation of HIV-1 gene and host gene transcription, pre-mRNA splicing, and cancer immunology. In the present study, we demonstrate a role for TIP110 in the regulation of hematopoiesis. TIP110 was expressed in human CD34+ cells and decreased with differentiation of CD34+ cells. TIP110 mRNA was also expressed in phenotyped mouse marrow hematopoietic stem cells (HSCs) and hematopoietic progenitor

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22

Dent, Alexander, L. "T cell regulation of hematopoiesis." Frontiers in Bioscience Volume, no. 13 (2008): 6229. http://dx.doi.org/10.2741/3150.

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23

Zhao, Jimmy L., and David Baltimore. "Regulation of stress-induced hematopoiesis." Current Opinion in Hematology 22, no. 4 (July 2015): 286–92. http://dx.doi.org/10.1097/moh.0000000000000149.

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24

Anderson, Georgina A., Melanie Rodriguez, and Katie L. Kathrein. "Regulation of stress-induced hematopoiesis." Current Opinion in Hematology 27, no. 4 (May 6, 2020): 279–87. http://dx.doi.org/10.1097/moh.0000000000000589.

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25

Chitteti, Brahmananda R., Monique Bethel, Melissa A. Kacena, and Edward F. Srour. "CD166 and regulation of hematopoiesis." Current Opinion in Hematology 20, no. 4 (July 2013): 273–80. http://dx.doi.org/10.1097/moh.0b013e32836060a9.

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26

Tall, Alan R. "Regulation of Hematopoiesis by Cholesterol." Blood 124, no. 21 (December 6, 2014): SCI—53—SCI—53. http://dx.doi.org/10.1182/blood.v124.21.sci-53.sci-53.

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Abstract Leukocytosis is a risk factor for athero-thrombotic disease in humans, and develops in animal models of atherosclerosis in response to feeding high-fat, high-cholesterol diets. The ATP binding cassette transporters ABCA1 and ABCG1 promote cholesterol efflux to apoA-1 and high density lipoprotein (HDL), respectively and are targets of liver X receptor (LXR) transcription factors. Mice lacking ABCA1/G1 develop a dramatic myeloproliferative phenotype with monocytosis and neutrophilia, associated with expansion and proliferation of hematopoietic stem and myeloid progenitor populations (HS

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27

Pantel, K., and A. Nakeff. "Lymphoid cell regulation of hematopoiesis." International Journal of Cell Cloning 7, no. 1 (1989): 2–12. http://dx.doi.org/10.1002/stem.5530070103.

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28

Hoggatt, J., and L. M. Pelus. "Eicosanoid regulation of hematopoiesis and hematopoietic stem and progenitor trafficking." Leukemia 24, no. 12 (September 30, 2010): 1993–2002. http://dx.doi.org/10.1038/leu.2010.216.

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29

Guo, Fukun, Wei Liu, Kankana Chava, Jose Cancelas, George Thomas, Sara C. Kozma, and Yi Zheng. "Role of mTOR in Hematopoiesis and Hematopoietic Stem Cell Regulation." Blood 114, no. 22 (November 20, 2009): 1490. http://dx.doi.org/10.1182/blood.v114.22.1490.1490.

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Abstract Abstract 1490 Poster Board I-513 The mammalian target of rapamycin (mTOR) integrates nutrients, growth factors, and cellular energy status to control protein synthesis that determines cell growth and metabolism. It is also known that mTOR plays an essential role in cell survival by regulating Akt/PKB signaling. By using the inhibitor rapamycin, mTOR has previously been suggested to regulate proliferation of megakaryocyte progenitors and late stage of megakaryocyte differentiation without a general impact on normal hematopoiesis or hematopoietic stem cell (HSC) function. Due to limitat

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30

Choi, Kyunghee. "Hemangioblast development and regulation." Biochemistry and Cell Biology 76, no. 6 (December 1, 1998): 947–56. http://dx.doi.org/10.1139/o99-007.

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Hematopoietic and endothelial cell lineages are the first to mature from mesoderm in the developing embryo. However, little is known about the molecular and (or) cellular events leading to hematopoietic commitment. The recent applications of technology utilizing gene targeted mice and the employment of many available in vitro systems have facilitated our understanding of hematopoietic establishment in the developing embryo. It is becoming clear that embryonic hematopoiesis occurs both in the extra-embryonic yolk sac and within the embryo proper in the mouse. The existence of the long pursued h

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31

Jeanson, Nathaniel T., and David T. Scadden. "Vitamin D receptor deletion leads to increased hematopoietic stem and progenitor cells residing in the spleen." Blood 116, no. 20 (November 18, 2010): 4126–29. http://dx.doi.org/10.1182/blood-2010-04-280552.

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Abstract Bone components participate in the regulation of hematopoietic stem cells in the adult mammal. Vitamin D regulates bone mineralization and is associated with pleiotropic effects in many cell types, including putative roles in hematopoietic differentiation. We report that deletion of the vitamin D receptor (VDR) in hematopoietic cells did not result in cell autonomous perturbation of hematopoietic stem cell or progenitor function. However, deletion of VDR in the microenvironment resulted in a marked accumulation of hematopoietic stem cells in the spleen that could be reversed by calciu

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32

Basu, Sreemanti, Irene Hernandez, Mark Zogg, Karen-Sue B. Carlson, and Hartmut Weiler. "Regulation of Hematopoiesis By the Coagulation Receptor Thrombomodulin." Blood 126, no. 23 (December 3, 2015): 4750. http://dx.doi.org/10.1182/blood.v126.23.4750.4750.

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Abstract BACKGROUND: Pharmacologic supplementation of protein C pathway function by infusion of recombinant Thbd or activated protein C supports recovery of hematopoietic function from lethal radiation injury in mice [Geiger et al., Nature Medicine, 2012]. Partial Thbd deficiency in hematopoietic stem and progenitor cells (HSPC) or bone marrow endothelium results in augmented sensitivity towards radiation injury [Geiger et al., Nature Medicine, 2012]. The underlying cellular and molecular mechanisms of Thbd function in hematopoiesis are not yet characterized. The objective of the current study

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33

Ganapati, Uma, Lynne A. Bui, Maureen Lynch, Milana Dolezal, Hongying Tina Tan, Sven deVos, and Judith C. Gasson. "Regulated Expression of Activated Notch 1 during Embryonic Stem Cell Differentiation Preserves Multipotential Progenitors and Promotes Erythroid Cell Fate." Blood 104, no. 11 (November 16, 2004): 4151. http://dx.doi.org/10.1182/blood.v104.11.4151.4151.

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Abstract Hematopoietic stem cells pass sequentially through a series of developmental decision points regulating self-renewal and lineage-specific differentiation. In normal hematopoiesis proliferation is tightly linked to differentiation in ways that are poorly understood. The Notch gene family has been shown to be evolutionarily conserved and to play an important role in determining cell fate, survival, and proliferation in multiple organisms. Numerous in vitro and in vivo studies strongly support a role for Notch signaling in the regulation of stem cell signaling and hematopoiesis. To defin

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34

Melotti, P., D. H. Ku, and B. Calabretta. "Regulation of the expression of the hematopoietic stem cell antigen CD34: role of c-myb." Journal of Experimental Medicine 179, no. 3 (March 1, 1994): 1023–28. http://dx.doi.org/10.1084/jem.179.3.1023.

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The CD34 antigen defines a subset of hematopoietic progenitor cells with self-renewal capacity and the ability to reconstitute hematopoiesis in irradiated primates and marrow-ablated humans, but its function remains unknown. The c-myb protooncogene plays a fundamental role in hematopoiesis, most likely via its transcriptional regulator function. We report that c-myb protein transactivates the CD34 promoter via specific interaction with multiple Myb binding sites in the 5' flanking region of the gene and induces expression of the endogenous CD34 mRNA in rodent fibroblasts. Also, constitutive ex

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35

Lin, Xionghui, and Irene Söderhäll. "Crustacean hematopoiesis and the astakine cytokines." Blood 117, no. 24 (June 16, 2011): 6417–24. http://dx.doi.org/10.1182/blood-2010-11-320614.

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Abstract Major contributions to research in hematopoiesis in invertebrate animals have come from studies in the fruit fly, Drosophila melanogaster, and the freshwater crayfish, Pacifastacus leniusculus. These animals lack oxygen-carrying erythrocytes and blood cells of the lymphoid lineage, which participate in adaptive immune defense, thus making them suitable model animals to study the regulation of blood cells of the innate immune system. This review presents an overview of crustacean blood cell formation, the role of these cells in innate immunity, and how their synthesis is regulated by t

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36

Zou, Gang-Ming, Mei-Hua Luo, April Reed, Mark R. Kelley, and Mervin C. Yoder. "Ape1 regulates hematopoietic differentiation of embryonic stem cells through its redox functional domain." Blood 109, no. 5 (October 19, 2006): 1917–22. http://dx.doi.org/10.1182/blood-2006-08-044172.

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Abstract Ape1 is a molecule with dual functions in DNA repair and redox regulation of transcription factors. In Ape1-deficient mice, embryos do not survive beyond embryonic day 9, indicating that this molecule is required for normal embryo development. Currently, direct evidence of the role of Ape1 in regulating hematopoiesis is lacking. We used the embryonic stem (ES) cell differentiation system and an siRNA approach to knockdown Ape1 gene expression to test the role of Ape1 in hematopoiesis. Hemangioblast development from ES cells was reduced 2- to 3-fold when Ape1 gene expression was knocke

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37

Stein, Sarah J., та Albert S. Baldwin. "Deletion of the NF-κB subunit p65/RelA in the hematopoietic compartment leads to defects in hematopoietic stem cell function". Blood 121, № 25 (20 червня 2013): 5015–24. http://dx.doi.org/10.1182/blood-2013-02-486142.

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Key Points p65 is an important factor in hematopoiesis through the regulation of hematopoietic stem cell function and lineage commitment. p65 controls the expression of genes encoding key factors that promote hematopoietic stem cell homeostasis.

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38

Stergiou, Ioanna E., and Efstathia K. Kapsogeorgou. "Autophagy and Metabolism in Normal and Malignant Hematopoiesis." International Journal of Molecular Sciences 22, no. 16 (August 9, 2021): 8540. http://dx.doi.org/10.3390/ijms22168540.

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The hematopoietic system relies on regulation of both metabolism and autophagy to maintain its homeostasis, ensuring the self-renewal and multipotent differentiation potential of hematopoietic stem cells (HSCs). HSCs display a distinct metabolic profile from that of their differentiated progeny, while metabolic rewiring from glycolysis to oxidative phosphorylation (OXPHOS) has been shown to be crucial for effective hematopoietic differentiation. Autophagy-mediated regulation of metabolism modulates the distinct characteristics of quiescent and differentiating hematopoietic cells. In particular

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39

Akashi, Koichi. "Transcriptional Regulation in Normal and Malignant Hematopoiesis." Blood 118, no. 21 (November 18, 2011): SCI—28—SCI—28. http://dx.doi.org/10.1182/blood.v118.21.sci-28.sci-28.

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Abstract SCI-28 Lineage commitment should involve selective and temporally-regulated expression of essential genes. In multi- or oligo-potent progenitors, the expression of oligo-lineage-affiliated genes is primed: oligo-lineage genes are co-expressed prior to the commitment at the single cell level, and once lineage fate is decided, genes of irrelevant lineages are immediately downregulated. For example, single common myeloid progenitors (CMP) co-express both granulocyte/monocyte-affiliated and megakaryocyte/erythroid-affiliated genes. The priming of these lineage-restricted genes could be de

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40

Huang, Gang, Shannon Elf, Xiaomei Yan, Lan Wang, Yan Liu, Goro Sashida, Alex Gural, et al. "Previously Unknown Interactions Between AML1 and MLL Provide Epigenetic Regulation of Gene Expression in Normal Hematopoiesis and in Leukemia." Blood 112, no. 11 (November 16, 2008): 282. http://dx.doi.org/10.1182/blood.v112.11.282.282.

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Abstract In all organisms, the fundamental process of transcriptional regulation requires transcription factors, which bind to DNA in response to extra-cellular signals and regulate transcription of target genes. In eukaryotes, this process also involves epigenetic regulation, which includes DNA and histone modifications. Hematopoiesis and leukemia are excellent model systems for studying the higher eukaryotic regulations of gene expression and for identifying important molecules involved in genetic and epigenetic transcriptional regulation. The Mixed-Lineage Leukemia (MLL) protein, a Set1-lik

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41

Gu, Yue, Wei Yang, Amanda Jones, Shanrun Liu, Qian Dai, C. Scott Swindle, Thomas Ryan, Tim M. Townes, Christopher Klug, and Hengbin Wang. "Regulation of Hematopoietic Stem Cell Function By the Histone H2A Deubiquitinase Usp16." Blood 126, no. 23 (December 3, 2015): 1177. http://dx.doi.org/10.1182/blood.v126.23.1177.1177.

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Abstract Epigenetic mechanism plays important regulatory roles in hematopoiesis and hematopoietic stem cell (HSC) function. Subunits of Polycomb repressive complex 1 (PRC1), the major histone H2A ubiquitin ligase, are critical for both normal and pathological hematopoiesis; however, it was unclear which H2A deubiquitinase pairs with PRC1 to control H2A ubiquitination (ubH2A) level in vivo and regulates hematopoiesis. Here we investigated the function of Usp16 in mouse hematopoiesis. Deletion of Usp16 in bone marrow resulted in a significant increase of global ubH2A level and mouse lethality. U

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Stellrecht, C. M., G. Fraizer, C. Selvanayagam, L. Y. Chao, A. Lee, and G. F. Saunders. "Transcriptional regulation of a hematopoietic proteoglycan core protein gene during hematopoiesis." Journal of Biological Chemistry 268, no. 6 (February 1993): 4078–84. http://dx.doi.org/10.1016/s0021-9258(18)53582-1.

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Migueles, Rosa Portero, Louise Shaw, Neil P. Rodrigues, Gillian May, Korinna Henseleit, Kathryn G. V. Anderson, Hakan Goker, et al. "Transcriptional regulation of Hhex in hematopoiesis and hematopoietic stem cell ontogeny." Developmental Biology 424, no. 2 (April 2017): 236–45. http://dx.doi.org/10.1016/j.ydbio.2016.12.021.

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Lin, Kuan-Hung, Jui-Chung Chiang, Ya-Hsuan Ho, Chao-Ling Yao, and Hsinyu Lee. "Lysophosphatidic Acid and Hematopoiesis: From Microenvironmental Effects to Intracellular Signaling." International Journal of Molecular Sciences 21, no. 6 (March 16, 2020): 2015. http://dx.doi.org/10.3390/ijms21062015.

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Vertebrate hematopoiesis is a complex physiological process that is tightly regulated by intracellular signaling and extracellular microenvironment. In recent decades, breakthroughs in lineage-tracing technologies and lipidomics have revealed the existence of numerous lipid molecules in hematopoietic microenvironment. Lysophosphatidic acid (LPA), a bioactive phospholipid molecule, is one of the identified lipids that participates in hematopoiesis. LPA exhibits various physiological functions through activation of G-protein-coupled receptors. The functions of these LPARs have been widely studie

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Cooney, Jeffrey D., Ebrahim Shafizadeh, Paul F. McBride, Kelli J. Carroll, Heidi Anderson, Jared J. Ganis, Trista E. North, and Barry H. Paw. "Zebrafish Growth Factor Independence Transcription Factors Establish a New Paradigm for Regulation of Primitive and Definitive Hematopoietic Lineages,." Blood 118, no. 21 (November 18, 2011): 3379. http://dx.doi.org/10.1182/blood.v118.21.3379.3379.

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Abstract Abstract 3379 The Growth Factor Independence (Gfi) zinc finger transcription factors play essential roles in hematopoiesis, differentially activating and repressing transcriptional programs required for hematopoietic lineage specification. In mammals, Gfi1 regulates hematopoietic stem cell (HSC) and lymphoid populations, while Gfi1b is required for megakaryocyte and erythroid development (van der Meer, et al. 2010 Leukemia 11:1834–43). In zebrafish, gfi1.1 plays an essential role in primitive hematopoiesis, preserving primitive HSC populations and regulating the erythroid-myeloid bala

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Lan, Wenwen, Sumin Liu, Long Zhao, and Ying Su. "Regulation of Drosophila Hematopoiesis in Lymph Gland: From a Developmental Signaling Point of View." International Journal of Molecular Sciences 21, no. 15 (July 24, 2020): 5246. http://dx.doi.org/10.3390/ijms21155246.

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The Drosophila hematopoietic system is becoming increasingly attractive for its simple blood cell lineage and its developmental and functional parallels with the vertebrate system. As the dedicated organ for Drosophila larval hematopoiesis, the lymph gland harbors both multipotent stem-like progenitor cells and differentiated blood cells. The balance between progenitor maintenance and differentiation in the lymph gland must be precisely and tightly controlled. Multiple developmental signaling pathways, such as Notch, Hedgehog, and Wnt/Wingless, have been demonstrated to regulate the hematopoie

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Weiss, L., and U. Geduldig. "Barrier cells: stromal regulation of hematopoiesis and blood cell release in normal and stressed murine bone marrow." Blood 78, no. 4 (August 15, 1991): 975–90. http://dx.doi.org/10.1182/blood.v78.4.975.975.

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Abstract Murine hematopoietic bone marrow is heterogenous in respect to bone- lining cells, hematopoiesis, and release of blood cells. In diaphyseal femoral marrow, bone-lining cells are largely osteoblasts, indifferent endosteum, blood cells, and reticular cells. Hematopoiesis is sustained by rather differentiated progenitors, as myelocytes and polychromatophilic erythroblasts. But in sharply restricted loci within trabeculated bone in the distal medial femoral metaphysis, bone-lining cells are dominated by newly discovered fibroblastic, contractile, stromal barrier cells; activated, multilam

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Weiss, L., and U. Geduldig. "Barrier cells: stromal regulation of hematopoiesis and blood cell release in normal and stressed murine bone marrow." Blood 78, no. 4 (August 15, 1991): 975–90. http://dx.doi.org/10.1182/blood.v78.4.975.bloodjournal784975.

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Abstract:

Murine hematopoietic bone marrow is heterogenous in respect to bone- lining cells, hematopoiesis, and release of blood cells. In diaphyseal femoral marrow, bone-lining cells are largely osteoblasts, indifferent endosteum, blood cells, and reticular cells. Hematopoiesis is sustained by rather differentiated progenitors, as myelocytes and polychromatophilic erythroblasts. But in sharply restricted loci within trabeculated bone in the distal medial femoral metaphysis, bone-lining cells are dominated by newly discovered fibroblastic, contractile, stromal barrier cells; activated, multilaminar and

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49

Prosper, Felipe, and Catherine M. Verfaillie. "Regulation of hematopoiesis through adhesion receptors." Journal of Leukocyte Biology 69, no. 3 (March 2001): 307–16. http://dx.doi.org/10.1189/jlb.69.3.307.

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Rafii, Shahin, Robert Mohle, Fred Shapiro, Beat M. Frey, and Malcolm A. S. Moore. "Regulation of Hematopoiesis by Microvascular Endothelium." Leukemia & Lymphoma 27, no. 5-6 (January 1997): 375–86. http://dx.doi.org/10.3109/10428199709058305.

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