Log in

Relevant bibliographies by topics / Hepato toxicity / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Hepato toxicity.

Dissertations / Theses on the topic 'Hepato toxicity'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 37 dissertations / theses for your research on the topic 'Hepato toxicity.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Bonfim, Daniel José Pimentel. "INFLUÊNCIA DO pH DA ÁGUA NA HEPATO E NEFROTOXICIDADE NA INTOXICAÇÃO CRÔNICA POR CÁDMIO EM RATOS WISTAR." Universidade do Oeste Paulista, 2014. http://bdtd.unoeste.br:8080/tede/handle/tede/298.

Full text

Abstract:

Made available in DSpace on 2016-01-26T18:55:40Z (GMT). No. of bitstreams: 1 Daniel Jose Pimentel Bonfim.pdf: 627142 bytes, checksum: c21af76961f71071fd84a086e01d5155 (MD5) Previous issue date: 2014-08-22<br>Introduction: Cadmium is a heavy metal found in the environment and used industrially and can cause hepato-and nephrotoxic effects. Objective: To evaluate the effect of pH of drinking water in the hepato-and nephrotoxicity caused by chronic cadmium poisoning. Methods: We used 90 Wistar albino rats, adult, male, divided into 6 groups (n = 15): GC5 - solution of cadmium chloride in drinkin

APA, Harvard, Vancouver, ISO, and other styles

2

Al-Attrache, Houssein. "Etude de la toxicité idiosyncratique de médicaments sur cellules HepaRG et levure : influence du stress inflammatoire et de la biotransformation." Thesis, Rennes 1, 2016. http://www.theses.fr/2016REN1B049/document.

Full text

Abstract:

Chez l’homme, de nombreux médicaments ne sont toxiques que chez un petit nombre de patients traités. Divers facteurs de susceptibilité, génétiques et autres (doses quotidiennes, stress inflammatoire, réaction immune, maladie hépatique,…), favoriseraient la survenue de ces toxicités de type idiosyncratique, non prévisibles par des études chez l’animal. Leur prédiction et la caractérisation des mécanismes impliqués représentent donc un challenge majeur. Dans ce travail, nous avons étudié in vitro l’influence d’un stress inflammatoire sur le potentiel cytotoxique, cholestatique et stéatosique de

APA, Harvard, Vancouver, ISO, and other styles

3

Wild, Stacie Lynn. "Pyrrolizidine alkaloids: Hepatic metabolism and extrahepatic toxicity." Diss., The University of Arizona, 1994. http://hdl.handle.net/10150/186599.

Full text

Abstract:

Pyrrolizidine alkaloids are proposed to be metabolized in the liver to reactive pyrrole species, or dehydroalkaloids. These reactive pyrroles are hypothesized to be responsible for pyrrolizidine alkaloid toxicity. This dissertation research has established that dehydroalkaloids are, in fact, metabolites of pyrrolizidine alkaloids. It was first determined that dehydromonocrotaline is produced during hepatic microsomal metabolism of monocrotaline and that it has the ability to bind in vitro with a synthetic thiol-containing resin, Thiopropyl Sepharose 6B. Similarly, synthetic dehydromonocrotalin

APA, Harvard, Vancouver, ISO, and other styles

4

Savary, Camille. "Étude de la toxicité chronique et du potentiel cancérogène de contaminants de l’environnement séparément et en mélange sur les cellules HepaRG." Thesis, Rennes 1, 2014. http://www.theses.fr/2014REN1B007/document.

Full text

Abstract:

L’Homme est exposé tout au long de sa vie à de nombreux contaminants présents dans l’environnement et l’alimentation généralement à faibles doses et en mélanges. L’évaluation des risques pose problème dans la mesure où il est bien établi qu’il existe des différences de réponse entre l’homme et l’animal. Quelle que soit la voie d’exposition, de par son rôle majeur dans la biotransformation des xénobiotiques, le foie est considéré comme un organe cible pour de nombreuses classes de produits chimiques potentiellement cytotoxiques, génotoxiques voire cancérogènes. Nous avons utilisé la lignée de c

APA, Harvard, Vancouver, ISO, and other styles

5

Smith, Marie-Caroline. "Incidence de la multi-contamination aux mycotoxines de Fusarium sur cellules humaines : évaluation de la cytotoxicité et approche toxico-protéomique." Thesis, Brest, 2017. http://www.theses.fr/2017BRES0084/document.

Full text

Abstract:

Les céréales et les produits issus de leur transformation sont susceptibles d’être contaminés par des espèces fongiques capables de produire des mycotoxines. L’Homme est ainsi exposé tout au long de sa vie à travers son alimentation à ces contaminants naturels, généralement à de faibles doses et en mélange. Cependant, l’incidence de la présence simultanée de ces toxines sur notre santé, à court terme comme à plus long terme, ainsi que les mécanismes responsables de leur toxicité sont encore peu ou mal caractérisés. L’utilisation de modèles cellulaires humains pertinents et adaptés est particul

APA, Harvard, Vancouver, ISO, and other styles

6

Powell, Christine Louise Rusyn Ivan. "Improving linkage of hepatic toxicity and pathology endpoints with toxicogenomics." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,997.

Full text

Abstract:

Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2007.<br>Title from electronic title page (viewed Dec. 18, 2007). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Curriculum in Toxicology." Discipline: Toxicology; Department/School: Medicine.

APA, Harvard, Vancouver, ISO, and other styles

7

Weyers, Carli. "Evaluating metabolism-induced toxicity using a non-hepatic cell line." Thesis, Rhodes University, 2018. http://hdl.handle.net/10962/61950.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Sauer, John-Michael. "All- trans-retinol modulation of chemically-induced pulmonary and hepatic toxicity." Diss., The University of Arizona, 1996. http://hdl.handle.net/10150/187501.

Full text

Abstract:

It has been previously reported that acute hypervitaminosis A in rats dramatically increases the hepatotoxicity of a number of chemicals. This potentiation appears to be mediated by the enhanced release of reactive oxygen species from retinol-primed Kupffer cells. However, in the lung it has been shown that retinol can protect against many of the inflammatory effects caused by bleomycin. Whether or not retinol pretreatment can modulate chemical-induced injury of compounds that cause both liver and lung toxicity is unknown. Therefore, the studies presented here were designed to test the hypothe

APA, Harvard, Vancouver, ISO, and other styles

9

Benlashehr, Imad. "Fumonisin toxicity in ducks and turkeys." Thesis, Toulouse, INPT, 2013. http://www.theses.fr/2013INPT0070/document.

Full text

Abstract:

Les fumonisines (FBs) sont les principales mycotoxines produites par Fusarium verticillioides et Fusarium proliferatum, qui se retrouvent partout dans le monde dans le maïs et ses produits dérivés. Les doses toxiques et les signes cliniques de toxicité provoqués par les FBs varient dune espèce à lautre. La toxicité des FBs est généralement liée à leur capacité à bloquer le métabolisme des sphingolipides chez les espèces animales, y compris chez les espèces aviaires. De précédentes études ont démontré que les canards présentent une plus grande sensibilité à la toxicité des FBs que les dindes, a

APA, Harvard, Vancouver, ISO, and other styles

10

Scott, Maya Millicent. "Canine hepatic slices as a model for studying drug toxicity and metabolism." Diss., Texas A&M University, 2005. http://hdl.handle.net/1969.1/3731.

Full text

Abstract:

Tissue slices can be made from organs, such as liver, kidney, brain, and heart, and from various species including humans, dogs, non-human primates, rats and mice. It has been demonstrated that human and rat liver slices are viable for up to 2 days, and liver slices have been extensively used as an in vitro method to study hepatic drug metabolism and toxicity in humans. The objective of this study was to determine the utility of canine hepatic slices as an in vitro model for studying drug metabolism and hepatotoxicity in dogs. Canine hepatic slices were incubated in media containing various dr

APA, Harvard, Vancouver, ISO, and other styles

11

de, Barros Pereira I. M. "Investigation of biomarkers of hepatic and renal toxicity in the Han Wistar rat." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1435551/.

Full text

Abstract:

The aim of this project was to identify urinary markers of hepatic and renal toxicity in the male Hanover-Wistar rat; acute and chronic injury models were developed by administration of CCl4. Nephrotoxicity was induced by administration of HCBD. In an acute dose study, CCl4-induced nephrotoxicity occurred above 2.0 mL/kg CCl4. To avoid kidney injury, 2.0 mL/kg CCl4 was chosen as the optimal dose. 1H NMR revealed many changes to the urinary metabolome following CCl4-induced liver injury including an increase in the resonances of taurine, creatine and formate and a decrease in hippurate and crea

APA, Harvard, Vancouver, ISO, and other styles

12

Celliere, Géraldine. "Multi-scale modeling of hepatic drug toxicity and its consequences on ammonia detoxification." Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC100.

Full text

Abstract:

La détoxification de l'ammoniaque est une fonction clé du foie. Récemment, il a été montré que les réactions communément admises dans ce processus étaient insuffisantes pour comprendre toutes les données expérimentales. Nous avons donc développé des explications possibles sous forme de modèles compartimentaux. Grâce à des procédures statistiques, les modèles ont été évalués et comparés. Il est apparu que l'enzyme glutamate déshydrogénase a une importance capitale dans la détoxification de l'ammoniaque. Lorsque l'on modélise des tissues, le choix de la représentation de l'espace peut influencer

APA, Harvard, Vancouver, ISO, and other styles

13

Mesić, Ana. "Space of Disse on Chip Model for Study of Hepatic Toxicity and Inflammation." Electronic Thesis or Diss., université Paris-Saclay, 2025. http://www.theses.fr/2025UPAST044.

Full text

Abstract:

Cette thèse de doctorat s'inscrit dans le cadre du projet ANR DILI on Chip, qui vise à développer un modèle hépatique in vitro sur une puce microfluidique afin d'étudier les lésions hépatiques induites par les médica-ments (Drug-Induced Liver Injury, DILI).Le développement actuel des médicaments repose sur des modèles obsolètes, tels que les cultures cellulaires 2D et les tests in vivo, qui sont coûteux, inefficaces et incapables de prédire avec précision la toxicité hépa-tique. La technologie des organes-sur-puce basée sur la microfluidique constitue une alternative plus précise et dynamique,

APA, Harvard, Vancouver, ISO, and other styles

14

Grave, Béatrice. "Caracterisation des mecanismes de defense de deux lignees d'hepatomes humains hep 3b et hep g2 : application a l'etude de la toxicite radicalaire du lindane et du paraquat." Lille 2, 1995. http://www.theses.fr/1995LIL2P256.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Geenen, Suzanne Aleida Birgitta. "Systems biology approach to understanding hepatic glutathione metabolism and its biomarkers of depletion." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/systems-biology-approach-to-understanding-hepatic-glutathione-metabolism-and-its-biomarkers-of-depletion(760cb481-d46b-494b-8aba-e8759aec025a).html.

Full text

Abstract:

Drug induced liver injury is a leading cause of human illness and a major cause of drug withdrawals from the market. A systems biology approach has the potential to aid toxicology research since toxicological responses are a consequence of multiple non-linear and interdependent biological responses. Here such an approach is developed.The glutathione pathway is a key hepatic defence mechanism and deactivates reactive metabolites before they have the chance to damage cellular proteins. However, glutathione availability is limited and can vary between individuals. As hepatic glutathione levels ca

APA, Harvard, Vancouver, ISO, and other styles

16

Cardoso, Elsa Maria Pereira. "Lymphocytes in the liver and hepatic iron toxicity : human and animal models of iron overload." Doctoral thesis, Porto : Edição do Autor, 2000. http://hdl.handle.net/10216/64561.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Cardoso, Elsa Maria Pereira. "Lymphocytes in the liver and hepatic iron toxicity : human and animal models of iron overload." Tese, Porto : Edição do Autor, 2000. http://catalogo.up.pt/F?func=find-b&local_base=UPB01&find_code=SYS&request=000087509.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Egloff, Caroline. "Effects of Four New Brominated Flame Retardants on Hepatic Messenger RNA Expression, In Vitro Toxicity and In Ovo Toxicity in the Domestic Chicken (Gallus gallus)." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/19969.

Full text

Abstract:

Brominated flame retardants (BFR) such as hexachlorocyclopentadienyl-dibromocyclooctane (HCDBCO), bis(2-ethylhexyl)tetrabromophthalate (BEHTBP), 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE) and decabromodiphenylethane (DBDPE) are contaminants of environmental concern. These BFRs are replacement alternatives for some of the major production BFRs, which have been restricted from the marketplace due to their adverse health effects. Their presence in environmental matrices, including wild birds, suggests they should be tested for possible toxic effects. BFR alternatives have been detected in the

APA, Harvard, Vancouver, ISO, and other styles

19

Duthie, Susan Joyce. "The HepG2 hepatoma cell line : a model for the metabolism and toxicity of xenobiotics in man." Thesis, University of Aberdeen, 1992. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU045924.

Full text

Abstract:

The aim of the study was to determine the suitability of the human hepatoma cell line, HepG2, as an in vitro model for xenobiotic metabolism and toxicity in man. Bromobenzene (BB) toxicity in HepG2 cells was not mediated by cy-tochrome P450 (P450), but was dependent upon culture medium and cell growth. Epoxide hydrase detoxified BB. Reduced glutathione (GSH) did not. Neither lipid peroxidation (LP), nor proteolysis accounted for toxicity. The anticancer agent, cyclophosphamide (CP), induced HepG2 cell death. P450 was protective. Neither GSH nor aldehyde dehydrogenase was important in CP detoxi

APA, Harvard, Vancouver, ISO, and other styles

20

Michaut, Anaïs. "Mise au point d'un modèle de stéatose hépatique liée à l'obésité : application à l'étude de la toxicité du paracétamol." Thesis, Rennes 1, 2015. http://www.theses.fr/2015REN1B015/document.

Full text

Abstract:

L'obésité et les maladies du foie associées (NAFLD) augmentent le risque et la sévérité de l’hépatotoxicité induite par certains xénobiotiques, mais les mécanismes impliqués sont encore mal compris. Pour l'éthanol et le paracétamol (APAP), le rôle du cytochrome P450 2E1 (CYP2E1) hépatique est suspecté car l'activité de cette enzyme est augmentée au cours de ces pathologies dysmétaboliques. Le 1er objectif de notre travail expérimental a été de mettre au point un modèle cellulaire de NAFLD caractérisé non seulement par l'accumulation de triglycérides mais aussi par l’augmentation de l'activité

APA, Harvard, Vancouver, ISO, and other styles

21

Boulais, Lilandra. "Cryogel-integrated hepatic cell culture microchips for liver tissue engineering." Thesis, Compiègne, 2020. http://www.theses.fr/2020COMP2561.

Full text

Abstract:

L’un des enjeux de l’industrie pharmaceutique aujourd’hui est de développer des modèles de foie in vitro fidèles pour améliorer la prédictivité des études précliniques, notamment l’étude de la toxicité et de l’efficacité des médicaments candidats. Ces dernières années, l’ingénierie tissulaire, approche multidisciplinaire pour développer des tissus, a mené au développement de nouvelles méthodes de culture cellulaire. Parmi elles, les cultures de cellules en 3D ou en perfusion ont permis d’obtenir des activités hépatiques similaires à celles observées in vivo. L’objectif de cette thèse est de co

APA, Harvard, Vancouver, ISO, and other styles

22

O'Brien, Jason. "The Effects of Perfluoroalkyl Compounds on In Ovo Toxicity and Hepatic mRNA Expression in the Domestic Chicken (Gallus gallus domesticus)." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/19924.

Full text

Abstract:

Perfluoroalkyl compounds (PFCs) are a group of chemical surfactants most notably used in non-stick and stain-resistance applications. Due to their wide-spread use and inherent resistance to degradation, several PFCs have become persistent environmental contaminants. Despite the high concentrations of PFCs reported in wild birds and their eggs, very little is known about the toxicological effects they have on avian species. This thesis investigates the developmental toxicity of PFCs in an avian model species: the domestic chicken (Gallus gallus domesticus). Egg injection experiments were perfor

APA, Harvard, Vancouver, ISO, and other styles

23

Lai, Ian Kwan-Tai. "Using dietary strategies to explore mechanisms of hepatic toxicity caused by 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) in an animal model." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/1157.

Full text

Abstract:

This doctoral dissertation work strived to contribute to the ever expanding knowledge about the mechanisms of polychlorinated biphenyl (PCB) toxicity using dietary strategies. PCBs are a family of persistent environmental pollutants with a wide range of toxicity. The toxicity of PCBs is largely dependent on the congener's chlorination pattern. Of particular interest to this work was 3,3',4,4',5-pentachlorobiphenyl (PCB 126), the most potent of the dioxin-like PCB congeners. I hypothesized that in vivo PCB 126 toxicity will be ameliorated by dietary selenium supplementation, lowered dietary cop

APA, Harvard, Vancouver, ISO, and other styles

24

Messelmani, Taha. "Development and characterisation of a biomimetic liver on chip featuring 3D hepatic coculture with an endothelial barrier." Electronic Thesis or Diss., Compiègne, 2023. http://www.theses.fr/2023COMP2736.

Full text

Abstract:

Au cours des programmes de développement de médicaments, des modèles animaux sont utilisés pour évaluer le métabolisme et la toxicité des médicaments. Plusieurs cadres juridiques sont établis pour le remplacement, la réduction et l'amélioration de ces expériences. Le foie est un organe central pour la détoxification des molécules exogènes. Par conséquent, le développement de modèles reproduisant les fonctions du foie reste un objectif ambitieux. Ces dernières années, l'association entre l'ingénierie tissulaire et la technologie des organes sur puce a conduit au développement de modèles alterna

APA, Harvard, Vancouver, ISO, and other styles

25

Prado, Regilane Matos da Silva. "Studies on cardiovascular and hepatic effects of trans-dehydrocrotonin, a clerodane diterpene isolated from Croton cajucara benth (sacaca)." Universidade Federal do CearÃ, 2005. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=6.

Full text

Abstract:

CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>Croton cajucara Benth (Euphorbiaceae) is a popular medicinal plant in the Amazon region of Brazil for the treatment of liver and kidney disorders and also to lower blood cholesterol. The trans-dehydrocrotonin (t-DCTN), is the major clerodane diterpene isolated from the stem bark of Croton cajucara, that showed gastroprotective, hypoglycemic and hypolipidemic effects. Since drugs that possess pharmacological properties are often associated with contradictory cardiovascular and hepatic effects with possible cytoprotection or cytotoxi

APA, Harvard, Vancouver, ISO, and other styles

26

El, Azzi Pamela. "Induction d’une cholestase par la chlorpromazine dans les cellules hépatiques humaines HepaRG : Etude des mécanismes impliqués et de l’influence d’un stress inflammatoire." Thesis, Rennes 1, 2014. http://www.theses.fr/2014REN1B009/document.

Full text

Abstract:

La survenue de lésions hépatiques représente une cause majeure de retrait des médicaments au cours de leur développement et après leur mise sur le marché. La manifestation la plus fréquente des effets secondaires liés aux médicaments est lacholestase qui résulte d’un blocage de la sécrétion biliaire. Ils peuvent être prévisibles, généralement dépendants de la dose, ou dans certains cas n’être observés que chez un nombre restreint de patients traités, par exemple avec la chlorpromazine (CPZ), un neuroleptique. Il s’agit alors d’une hépatotoxicité idiosyncratique. Notre travail a eu pour but d’i

APA, Harvard, Vancouver, ISO, and other styles

27

Alvergnas-Vieille, Magalie. "Effets du bézafibrate sur l'expression et la régulation des enzymes du métabolisme des xénobiotiques et sur le protéome hépatique dans les cultures primaires d'hépatocytes de rat et d'Homme. Impact de l'environnement redox." Thesis, Besançon, 2011. http://www.theses.fr/2011BESA3004.

Full text

Abstract:

Le foie est le principal organe impliqué dans la biotransformation des xénobiotiques. Les cytochromes P450 (CYP) en sont des enzymes dés. Parmi elles, leCYP4A est impliqué dans rhydroxylatlon des acides gras et la biotransformation de médicaments, tels que le bézafibrate (BE2A), un hypolipémiant utilisé enthérapeutique humaine. Cette molécule a été montrée hépatocarcinogène chez les rongeurs mais cet effet n'a pas été rapporté chez l'Homme. H est doncimportant de connaître les mécanismes d'action impliqués dans les effets du BEZA chez l'Homme. Dans une première étude, nous avons étudié l'expre

APA, Harvard, Vancouver, ISO, and other styles

28

Campos, Neto Armindo de Arruda. "Níveis de exposição a vapores orgânicos e consequências psicofísicas, neurocognitivas e fisiológicas em uma amostra de frentistas brasileiros." Universidade Federal da Paraíba, 2013. http://tede.biblioteca.ufpb.br:8080/handle/tede/6955.

Full text

Abstract:

Made available in DSpace on 2015-05-14T13:16:23Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 3324327 bytes, checksum: b85304a7fe276b9b7697e2cdf5a23471 (MD5) Previous issue date: 2013-12-06<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>This study aimed at verifying exposure levels for gasoline and ethanol vapors and their psychophysical, neurocognitive, and physiological consequences in a sample of Brazilian pump attendants. Gas chromatography and microclimate sensing were used to passive and active monitoring of environmental levels of vapors. The psychophysic

APA, Harvard, Vancouver, ISO, and other styles

29

Marcelino, Renato Ivan de Ávila. "Estudo da atividade quimioprotetora in vitro e in vivo da Eugenia dysenterica dc. (Myrtaceae) após exposição ao cromo hexavalente." Universidade Federal de Goiás, 2013. http://repositorio.bc.ufg.br/tede/handle/tede/3679.

Full text

Abstract:

Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2014-11-24T12:08:05Z No. of bitstreams: 2 Dissertação - Renato Ivan de Ávila Marcelino - 2013.pdf: 1307159 bytes, checksum: 353b525742af80ec75afbd4c58f79c96 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2014-11-24T14:01:41Z (GMT) No. of bitstreams: 2 Dissertação - Renato Ivan de Ávila Marcelino - 2013.pdf: 1307159 bytes, checksum: 353b525742af80ec75afbd4c58f79c96 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a77147

APA, Harvard, Vancouver, ISO, and other styles

30

Nhiwatiwa, Melody. "Comparison of drug-induced hepato-toxicity in female patients during anti-retroviral therapy." Thesis, 2014.

Find full text

Abstract:

A research report submitted to the Faculty of Health Sciences, University of the Witwatersrand, in partial fulfillment of the requirements for the degree of Master of Science in Medicine in Pharmacotherapy, Johannesburg, 2011<br>Long term antiretroviral therapy (ART) use is known to cause various toxic adverse effects in patients. Hepato-toxicity is one of the most significant adverse effects which have been associated with all antiretroviral therapy drugs in South Africa and worldwide.

APA, Harvard, Vancouver, ISO, and other styles

31

Rebelo, Sofia Raquel Paulo. "Development of 3D in vitro models for prediction of hepatic metabolism and toxicity." Doctoral thesis, 2015. http://hdl.handle.net/10362/15268.

Full text

Abstract:

The development of human cell models that recapitulate hepatic functionality allows the study of metabolic pathways involved in toxicity and disease. The increased biological relevance, cost-effectiveness and high-throughput of cell models can contribute to increase the efficiency of drug development in the pharmaceutical industry. Recapitulation of liver functionality in vitro requires the development of advanced culture strategies to mimic in vivo complexity, such as 3D culture, co-cultures or biomaterials. However, complex 3D models are typically associated with poor robustness, limited sca

APA, Harvard, Vancouver, ISO, and other styles

32

Silva, Rui Gonçalo Teixeira da. "The effect of silver nanoparticles: a chronic in vivo study for the evaluation of hepatic mitochondrial toxicity." Master's thesis, 2014. http://hdl.handle.net/10316/28174.

Full text

Abstract:

Dissertação de mestrado em Bioquímica, apresentada ao Departamento de Ciências da Vida da Faculdade de Ciências e Tecnologia da Universidade de Coimbra.<br>Manufactured nanomaterials have been of extreme importance due to the beneficial physicochemical properties they possess compared to bulk parental materials. However, the properties that make them so attractive are also the same that can cause harm both to humans and environment. Over the last years there has been a rapid development of the nanotechnology industry and the inevitable human exposure tends rapidly to expand, accompanied by pot

APA, Harvard, Vancouver, ISO, and other styles

33

Costa, Daniela Filipa de Oliveira. "Hepatic differentiation of skin-derived stem cells and their application within in vitro toxicity testing." Master's thesis, 2016. http://hdl.handle.net/10451/34619.

Full text

Abstract:

Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2016<br>Steatosis is the hepatic accumulation of lipids. Despite being the least severe stage of Non-Alcoholic fatty liver disease, evaluation of steatosis is a mechanistic assay for toxin-induced liver injury, mandatory for the development of new chemical entities. Toxin-induced liver injury represent a major concern to the pharmaceutical industry. The discontinuation of the development of new compounds, in addition with the withdrawal of market drugs, represent an immense economic imp

APA, Harvard, Vancouver, ISO, and other styles

34

LU, WEI-HAN, and 呂維翰. "Dose-Volume Factors Analysis for Radiation-Induced Hepatic Toxicity in Patients with Hepatocellular Carcinoma after Radiotherapy." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/pan373.

Full text

Abstract:

碩士<br>國立高雄科技大學<br>電子工程系<br>107<br>Purpose : To assess the dose-volume factors analysis of radiation - induced hepatic toxicity (RIHT) in patients with hepatocellular carcinoma (HCC) after radiotherapy. Materials and methods : The study is retrospectively collected between 2014 and 2017, 114 patients with HCC underwent intensity modulation radiation therapy (IMRT). Of those, liver dose - volume receiving of less than 700 cc and extreme value excluded with remain only 69 patients and to use the bootstrapping of reached 138 samples. Assess blood draw rises level during the course of the patient's

APA, Harvard, Vancouver, ISO, and other styles

35

Huang, Chi-Chang, and 黃啟彰. "Effects of Chronic Alcoholic Toxicity on Antioxidative Status and Hepatic Morphologic Changes by Lieber-DeCarli Animal Model." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/49349388686977521225.

Full text

Abstract:

博士<br>臺北醫學大學<br>藥學系<br>93<br>This dissertation had two major parts; one was to evaluate the correlation between gender differences and chronic alcoholic liver disease. In addition, effects of gender differences on jejunal lipase and disaccharidase activities, the liver function tests, metabolic disorders and oxidative damage were also examined. Another major part was to examine oxidative stress of alcoholic injury and carbon tetrachloride- induced damage in relation to risk factors for liver disease. The first part of this study was to investigate the effects of gender differences on alcoholic

APA, Harvard, Vancouver, ISO, and other styles

36

Chang, Sheng-Wen, and 張勝文. "In Vitro Studies of Cadmium and 2,3,7,8-terachloro-dibenzo-p- dioxin (TCDD) Toxicity in Cultured Human Hepatoma and Eel (JAPONICA, AUGUILIA) Hepatocyte." Thesis, 1997. http://ndltd.ncl.edu.tw/handle/59068344752679791376.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Roquito, Tiago José Brasil. "The impact of curcumin-encapsulated glucan nanoparticles on hepatic cells and immune cells: oxidative stress and immunomodulatory properties." Master's thesis, 2021. http://hdl.handle.net/10316/99107.

Full text

Abstract:

Dissertação de Mestrado em Biotecnologia Farmacêutica apresentada à Faculdade de Farmácia<br>Nanotechnology is experiencing a rising interest from the pharmaceutical field due to the ability of nanoparticles (NPs) to increase the safety and efficiency of encapsulated drugs. Curcumin is a polyphenol with great therapeutic properties, especially regarding its anti-cancer abilities. However, its pharmacokinetics are poor, having poor bioavailability and being rapidly metabolized and excreted in vivo. The NPs chosen to overcome the curcumin’s poor pharmacokinetics were glucan NPs, as glucan has gr

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!