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Journal articles on the topic 'Hepato toxicity'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Deglmann, C. J., R. Metzger, M. Stickel, S. Hoerrlein, F. W. Schildberg, and H. G. Koebe. "A New Bioassay Including a Small Scale Hepatocyte Bioreactor for Hepato-Mediated Toxicity Testing in a Target Cell Line." International Journal of Artificial Organs 25, no. 10 (2002): 975–84. http://dx.doi.org/10.1177/039139880202501012.

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New approaches for in vitro testing of hepato-mediated toxicity are undertaken to offer alternatives to in vivo animal testing. The described bioassay for hepato-mediated toxicity testing is based on a small scale hepatocyte-bioreactor with pig hepatocytes connected to a silicon sensor based microphysiometer system for monitoring of the extracellular acidification rate (EAR) of cells and the microphysiometer alone. EAR represents the metabolic activity of tested cells (hepatocytes and ZR 751 cells) under the influence of perfused media, compared to controls, which were set to 100%. Cyclophosph

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Udavant, Pavan, Pragati Gurav, Gayatri Kanade та ін. "Evaluation of Hepatoprotective and Nephroprotective Effect of Α- Pinene on Wistar Albino Rat". Biomedical and Pharmacology Journal 16, № 1 (2023): 103–12. http://dx.doi.org/10.13005/bpj/2592.

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Introduction: Hepato-renal toxicity is a devastating, non-communicable disease. Because of a lack of information on low-cost management to combat the disease, this study postulates the ameliorative effect of selected phytoconstituents against toxicity. Aim and Objective: The current study reveals an active phytoconstituent, α- Pinene, that has the ability to combat the degenerative effects of CCl4. Methodology: Carbon tetrachloride (CCl4) is an organic xenobiotic molecule as well as the most potent hepatotoxic agent used (1200 mg/kg body weight; i.p.) to induce hepato-renal toxicity in experim

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Yuliana, Ida, Triawanti, Muhammad Darwin Prenggono, Ika Kustiyah Oktaviyanti, Irfan Maulana, and Fahrina Ulfah. "Effect of Mercury Administration as an Oxidative Stress Trigger in Hepato-Renal Injuries." JURNAL KESEHATAN LINGKUNGAN 17, no. 2 (2025): 159–67. https://doi.org/10.20473/jkl.v17i2.2025.159-167.

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Introduction: Mercury as the source of free radicals can trigger the activation of oxidative stress pathways. With its high toxicity, it can cause hepato-renal injuries. There have been many studies on mercury toxicity in various organs, but there are still few scientific studies that examine the hepato-renal injuries caused by mercury through the oxidative stress pathway. This study was conducted to investigate the triggering of the oxidative stress pathway due to mercury exposure in hepato-renal injuries. Methods: Research using randomized true laboratory experiment method with post-test con

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Abdullah, A. H., and S. A. Althanoon. "The Immunohistochemical Study of Doxorubicin on Liver and Kidney Tissues in albino Rats." IOP Conference Series: Earth and Environmental Science 1449, no. 1 (2025): 012025. https://doi.org/10.1088/1755-1315/1449/1/012025.

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Abstract The current study was conducted to check the influence of DOX on the liver and kidney of male albino rats. The current work was carried out in a research setting, on characterizing the DOX-induced hepato-renal toxicity model in terms of immunochemical evaluations to provide a methodological reference for studying potential therapeutic drugs with hepato-renal effects. The experiences were performed using two groups of healthful male albino rats (12 rats/group). The control group was given normal saline while the experimental group received a singular dosage of DOX at a concentration of

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Ebito, Gabriel, Adelaja Akinlolu, Mubarak Ameen, et al. "In vivo anti-inflammatory effects of anti-toxic principles from Moringa oleifera(MO11) and Musa sapientum (MS06) via NF-KB/IL-4/IL-10- mediated pathway in Cadmium Chloride-induced hepato-toxicity." Anatomy Journal of Africa 12, no. 1 (2023): 2269–78. http://dx.doi.org/10.4314/aja.v12i1.3.

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Cadmium-induction of hepato-toxicity and inflammation in animal models have been reported. The mechanism underlying hepatic inflammation is poorly understood. This study evaluated antiinflammatory potentials of MO11 (isolated from Moringa oleifera leaves) and MS06 (isolated from Musa sapientum suckers) in Cadmium Chloride (CdCl)-induced hepato-toxicity and inflammation in rats.Twenty-eight adult male wistar rats (average weight of 155 g) were randomly divided into 7 groups (n = 4). Group 1 was control. Groups 2 - 4 and 7 received single intraperitoneal administration of 1.5 mg/Kg bodyweight of

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AKINLOLU, ADELAJA A., TEMITOPE OMOHIMORIA, ADEOYE OYEWOPO, RISIKAT E. KADIR, and MUBARAK O. AMEEN. "Anti-Toxic Principles from Morinda lucida and Annona muricata Down-Regulated Ki67 and Multi-Drug Resistance1 Genes in Lead-Induced Hepato-Toxicity in Rats." Malaysian Journal of Pharmaceutical Sciences 20, no. 2 (2022): 135–46. http://dx.doi.org/10.21315/mjps2022.20.2.11.

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Morinda lucida (ML) and Annona muricata (AM) are ethno-medicinal plants with antioxidant potentials. In addition, lead is a toxic pollutant of global health concerns. This study evaluated the effects of column chromatography-extracted ethanolic fractions of ML and AM leaves on immuno-modulations of Ki67 and multi-drug resistance1 (MDR1) proteins in the liver of rats in lead acetate (LA)-induced hepato-toxicity in-order to determine their hepato-protective, anti-proliferation, anti-drug resistance and anti-cancer potentials. Sixty adult female rats were randomly divided into 12 groups (n = 5).

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Waly, Hanan Salah Ahmed, Mohamed Bassam Al-Salahy, Wafaa Mohammed Hassan El-Arably, Magdy Wilson, and Khaled Mohamed Ahmed Hassanein. "Hepato- and nephro-toxicity of coumatetralyl rodenticide in some wild rat species." Journal of Multidisciplinary Sciences 2, no. 2 (2020): 49–55. http://dx.doi.org/10.33888/jms.2020.226.

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Coumatetralyl (COM) is an anticoagulant rodenticide absorbed quickly after oral dosing. It causes rodent’s death due to internal or external bleeding after complete depletion of plasma vitamin K-dependent coagulation factors. The present study aimed was to shed light on metabolic alterations as the potential hepato- and nephrotoxicity caused by ¼ LD50 COM in Rattus rattus, Arvicanthis niloticus, and Geribellus geribellus wild rat species. Elevation in plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin, total free amino acids, and erythrocyte lysate glucose-6-phosp

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8

Dar, AA, A. Fehaid, S. Alkhatani, et al. "The protective role of luteolin against the methotrexate-induced hepato-renal toxicity via its antioxidative, anti-inflammatory, and anti-apoptotic effects in rats." Human & Experimental Toxicology 40, no. 7 (2021): 1194–207. http://dx.doi.org/10.1177/0960327121991905.

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Methotrexate (MTX) is frequently used drug in treatment of cancer and autoimmune diseases. Unfortunately, MTX has many side effects including the hepato-renal toxicity. In this study, we hypothesized that Luteolin (Lut) exhibits protective effect against the MTX-induced hepato-renal toxicity. In order to investigate our hypothesis, the experiment was designed to examine the effect of exposure of male rats to MTX (20 mg/kg, i.p., at day 9) alone or together with Lut (50 mg/kg, oral for 14 days) compared to the control rats (received saline). The findings demonstrated that MTX treatment induced

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Sumathi Rajamani, Gobinath Kalyanasundaram, Tamizharasi Sengodan, Sivakumar Thangavelu, Nikhitha K Shanmukhan, and Arun Radhakrishnan. "Hepato & nephro protective effects of naringenin-loaded tpgs polymeric nanosuspension against cisplatin-induced toxicity." International Journal of Research in Pharmaceutical Sciences 10, no. 4 (2019): 2755–64. http://dx.doi.org/10.26452/ijrps.v10i4.1544.

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Cisplatin (Cis-Diammineplatinum (II) dichloride/CIS) is one of the most potent chemotherapeutic agents widely used in treatment of various cancers. Naringenin (NAR), a natural flavonoid, protect against CIS-induced injury in rats without hampering CIS beneficial cytotoxic activity. Even though NAR exhibits therapeutic potency, clinical evolution of the molecule is embarrassed because of very less aqueous solubility which corresponds to low availability at the site of the tumor. In our former analysis, nanosuspension of naringenin (NARNS) was developed by the method of high-pressure homogenizat

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Rana, Suresh V. S., and Nidhi Rastogi. "Effects of Cadmium On Liver Function in Diabetic Rats." Toxicology and Industrial Health 14, no. 3 (1998): 473–77. http://dx.doi.org/10.1177/074823379801400306.

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Hepato-toxicity of cadmium in alloxan induced diabetic rats has been studied by estimating a few enzymes viz serum glutamic oxalacetic transaminase, glutamic pyruvic transaminase, alkaline phosphatase and γ-glutamyltranspeptidase. Present results suggest that cadmium manifests difterent effects in normal and diabetic rats. Insulin therapy helps in restoring the liver function. It is suggested that an isozyme of cytochrome P450 that appears in diabetic rats might be responsible for altered toxicity of cadmium.

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11

Nang, Trinh Dinh, Nguyen Minh Hai, Tran Thi Thu Huong, et al. "Subchronic toxicity study of efcovida powder in experimental animals." Tạp chí Nghiên cứu Y học 161, no. 12E11 (2022): 27–34. http://dx.doi.org/10.52852/tcncyh.v161i12e11.996.

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The purpose of this study was to evaluate the subchronic toxicity of Efcovida powder through oral administration in experimental animals. The subchronic toxicity was studied in Wistar rats with oral doses of 90 mg/kg/day and 270 mg/kg/day in 90 consecutive days based on guidance of the World Health Organization and Organisation for Economic Co-operation and Development. Our result showed that Efcovida powder had no deleterious effect on hematological parameters, hepato-renal functions, macroscopic and microscopic images of livers and kidneys of rats. In conclusion, Efcovida powder did not prod

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Adefola, Edward Tolulope, Ajibade Adeshina John, and Edward Sylvester Sunday. "Effects of Lutein on the Body Weights, Hepato-renal DNA and Antioxidant Capacity Following Paraquat-induced Toxicity in Wistar Rats." South Asian Research Journal of Applied Medical Sciences 6, no. 05 (2024): 132–40. http://dx.doi.org/10.36346/sarjams.2024.v06i05.002.

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Introduction: Paraquat is a leading cause of herbicide-related fatalities worldwide. Its high mortality rate is attributed to its inherent generation of ROS-mediated toxicity, and lack of effective treatment till date. Lutein is an antioxidant with free radical scavenging ability, which may contribute to its protective effects and possible DNA preservation. Objective: The study is evaluating the effects of lutein on body weights and hepato-renal antioxidant capacity with DNA quantification following paraquat toxicity in wistar rats. Methods: Thirty-five male Wistar rats (150-180g) rats were ra

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Khokhar, Aamna, Iram Kehkashan Khurshid, Sadia Lodhi, et al. "N-Acetyl Cysteine Ameliorates Hepatotoxicity Associated with the Use of Methotrexate in Mice." Pakistan Journal of Medical and Health Sciences 15, no. 5 (2021): 1008–10. http://dx.doi.org/10.53350/pjmhs211551005.

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Background: Liver is not only involved in maintaining homeostasis but also exhibits significant role in metabolism and detoxification of various drugs and toxins. Aim: To explore the hepato-protective role of N-acetylcysteine against methotrexate induced hepato-toxicity. Study design: Randomized controlled trial. Methodology: This study having mice (n=18) was carried out after ethical review committee’s (ERC) approval at Foundation university medical college in collaboration of National institute of health, Islamabad in 2017. Single intraperitoneal injection (20mg/kg) of methotrexate induced h

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Khokhar, Aamna, Iram Kehkashan Khurshid, Sadia Lodhi, et al. "N-Acetyl Cysteine Ameliorates Hepatotoxicity Associated with the Use of Methotrexate in Mice." Pakistan Journal of Medical and Health Sciences 15, no. 5 (2021): 1008–10. http://dx.doi.org/10.53350/pjmhs211551008.

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Background: Liver is not only involved in maintaining homeostasis but also exhibits significant role in metabolism and detoxification of various drugs and toxins. Aim: To explore the hepato-protective role of N-acetylcysteine against methotrexate induced hepato-toxicity. Study design: Randomized controlled trial. Methodology: This study having mice (n=18) was carried out after ethical review committee’s (ERC) approval at Foundation university medical college in collaboration of National institute of health, Islamabad in 2017. Single intraperitoneal injection (20mg/kg) of methotrexate induced h

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15

Cha, Nguyen Thi, Ho Phu Ha, Nguyen Tien Thanh, et al. "In vivo assessment of acute and subchronic toxicity of Nanochitin in experimental animals." Tạp chí Nghiên cứu Y học 190, no. 5E16 (2025): 137–44. https://doi.org/10.52852/tcncyh.v190i5e16.3508.

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This study aimed to evaluate the safety of Nanochitin through oral administration in experimental animals. The acute toxicity was determined in mice at ascending doses and the subchronic toxicity was evaluated in rats with oral doses of 15.6 mg/kg b.w/day and 46.8 mg/kg b.w/day for 30 days. As a result, in the course of the acute toxicity test, Nanochitin at the highest dose of 750 mg/kg did not express acute toxicity in mice. Along with the subchronic toxicity test, Nanochitin had no deleterious effect on hematological parameters, hepato-renal functions, macroscopic and microscopic images of

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16

Fihri, Aicha Fassi, Noori S. Al-Waili, Redouan El-Haskoury, et al. "Protective Effect of Morocco Carob Honey Against Lead-Induced Anemia and Hepato-Renal Toxicity." Cellular Physiology and Biochemistry 39, no. 1 (2016): 115–22. http://dx.doi.org/10.1159/000445610.

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Background/Aims: Natural honey has many biological activities including protective effect against toxic materials. The aim of this study was to evaluate the protective effect of carob honey against lead-induced hepato-renal toxicity and lead-induced anemia in rabbits. Methods: Twenty four male rabbits were allocated into four groups six rabbits each; group 1: control group, received distilled water (0.1 ml / kg.b.wt /daily); group 2: received oral lead acetate (2 g/kg.b.wt/daily); group 3: treated with oral honey (1g /kg.b.wt/daily) and oral lead (2 g/kg.b.wt/daily), and group 4: received oral

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17

Elkomy, Ashraf, Mohamed Aboubakr, Ahmed Soliman, Ahmed Abdeen, Afaf Abdelkader, and Haitham Hekal. "Paracetamol induced hepatic toxicity and amelioration by cinnamon in rats." International Journal of Pharmacology and Toxicology 4, no. 2 (2016): 187. http://dx.doi.org/10.14419/ijpt.v4i2.6529.

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The study was designed to evaluate the hepato-protective activity of aqueous extract of cinnamon in acute experimental liver injury induced by paracetamol. Twenty four male albino rats were randomly divided into four groups (six rats in each). Group I rats received distilled water for 15 days and served as a vehicle control. The animals in the group II were given single oral administration of paracetamol (1 g/kg), 1 h after last distilled water administration and acts as paracetamol toxic control group. Groups III and IV received aqueous extract of cinnamon (200 and 400 mg/kg bwt), respectivel

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Doval, Divya, Sanjeev Kumar Sharma, Meet Kumar, Vipin Khandelwal, and Dharma Choudhary. "Cytarabine ears – A side effect of cytarabine therapy." Journal of Oncology Pharmacy Practice 26, no. 2 (2019): 471–73. http://dx.doi.org/10.1177/1078155219848800.

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Cytarabine, a pyramidine analog, is used for treating various hematological malignancies such as acute leukemias and lymphomas. Side effects of cytarabine are dose dependent and include bone marrow suppression, fever, cerebellar toxicity, cardiomyopathy, hepato-renal insufficiency, necrotizing enterocolitis, pancreatitis, acute respiratory distress, corneal toxicity and dermatological side effects. The dermatological side effects can be immediate or due to delayed hypersensitivity reactions. They have been attributed largely to release of cytokines. We present three such cases of delayed hyper

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Oanh, Le Hong, Hoang Minh Chau, Khuat Van Manh, et al. "Evaluation of subchronic toxicity of diabetna capsules in experimental animals." Tạp chí Nghiên cứu Y học 177, no. 4E14 (2024): 149–57. http://dx.doi.org/10.52852/tcncyh.v177i4e14.2423.

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This research aimed to evaluate the subchronic toxicity of Diabetna capsules through oral administration in experimental animals. The subchronic toxicity was studied in Wistar rats with oral doses of 0.72 g/kg/day (equal to recommended human dose) and 2.16 g/kg/day (3 times as high as recommended human dose) in consecutive 12 weeks, following guidance from the World Health Organization and Organisation for Economic Co-operation and Development. Our result showed that Diabetna capsules had no deleterious effect on hematological parameters, hepato-renal functions, macroscopic and microscopic ima

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Vikrant, Sanjay. "Hepato-renal toxicity-associated with methyl parathion exposure." Renal Failure 37, no. 2 (2014): 355–56. http://dx.doi.org/10.3109/0886022x.2014.986620.

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Oghenetega, Onome B., Fathia O. Ibrahim, Gloria E. Oghenetega, Rufus O. Animashaun, and Patrick G. Okwute. "Ameliorative Potentials of N-Acetylcysteine and Vitamin C on Zinc-oxide Nanoparticles Induced Hepato-renal Toxicity in Male Wistar Rats." Nigerian Journal of Biochemistry and Molecular Biology 39, no. 3 (2024): 129–35. https://doi.org/10.4314/njbmb.v39i3.2.

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Zinc-oxide nanoparticles (ZnO-NPs) are prevalent in various companies and consumer products, raising concerns about their potential toxicity. Vitamin C and N-acetyl-cysteine (NAC) are known for their antioxidant properties, which may protect against cytotoxicity. However, limited information exists on their effects on ZnO-NPs-induced toxicity. This study investigates the ameliorative effects of N-acetylcysteine and vitamin C on hepato-renal toxicity of Zinc-oxide Nanoparticles in Male Wistar Rats. Twenty-five male Wistar rats (100-120g) were grouped namely; Control, ZnO-NPs, ZnO-NPs + NAC, ZnO

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Muhammad Bilal, Ghazala Shaheen, Syed Hassan Mustafa, et al. "Hepatic safety of low dose methotrexate therapy in patients with Rheumatoid Arthritis." Professional Medical Journal 29, no. 06 (2022): 791–96. http://dx.doi.org/10.29309/tpmj/2022.29.06.6870.

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Objective: To determine the Hepatic safety of low dose methotrexate therapy in patients with Rheumatoid Arthritis. Study Design: Prospective and Descriptive study. Settings: Department of Medicine, Peshawar Institute of Medical Sciences. Period: May 2020 to May 2021. Material & Methods: A total of 151 patients with rheumatoid Arthritis were included in this study. All diagnosed patients were advised baseline liver function tests and routine blood investigations. Patients were started on methotrexate 7.5 mg weekly. On each monthly follow-up visit, liver function tests were done to detect he

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Ehgendy, Fatma, Rania M. Waheed, Samer Ibrahim, Elshaimaa Said, and Faten Elsayed. "Ameilorative effect of lycopine against cisplatin toxicity in rats." International Journal of Pharmacology and Toxicology 9, no. 2 (2021): 84. http://dx.doi.org/10.14419/ijpt.v9i2.31687.

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The following study aimed to investigate the hepato and neuro protective efficacy of Lycopine against Cisplatin which induced hepatotoxicity and neurotoxicity. Twenty Five male Wister rats were used for this experiment they were equally divided into 5 groups (5 rats per group): group (1) served as control group they were injected 1ml saline orally once daily for 20 day, group (2) served as Corn Oil group and they were administrated 1 mL Corn Oil orally once daily for 20 days, group (3) served as Lycopine group and they were administrated (10 mg/kg b.wt) Lycopine orally once daily for 20 days.

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Hafiz, Ahmad Jalal Hafiz Ahmad Bilal Hafiz Ahmad Kamal Ayesha Khalid. "ROLE OF ZINC SULPHATE IN PARACETAMOL TOXICITY." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 05 (2018): 3331–34. https://doi.org/10.5281/zenodo.1241491.

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OBJECTIVE: Research objective was the determination of the Zinc Sulphate role as an agent of hepatoprotective in the acetaminophen-induced changes of histopathological nature in the model of animals. DESIGN: Research was Observational Experimental in nature. SETTING: Research was carried out in the Pathology and Pharmacology Department Mayo Hospital Lahore from Dec, 2016 to Mar, 2017. METHODOLOGY: Our research sample was 90 albino rats with the range of weight from 18 – 32 grams and we made three groups each group consisting of thirty albino rats. Control group was A group and normal sal

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Tung, Tran Thanh, Nguyen Thanh Binh, and Dang Thi Thu Hien. "Acute and sub-chronic toxicities of phatra tricholes capsule in experimental animals." Tạp chí Nghiên cứu Y học 177, no. 4E14 (2024): 115–23. http://dx.doi.org/10.52852/tcncyh.v177i4e14.2281.

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Phatra Tricholes capsule is a multiplant production planned for dyslipidemia patients. Herein, we assessed the potential toxicity of Phatra Tricholes, applying the protocol of acute and sub-chronic oral administration in experimental animal models. According to the WHO guidelines, the acute toxicity study was conducted on Swiss mice. Sub-chronic toxicity studies were conducted in Wistar rats, and oral administration was done at 0.11 and 0.33 g/kg for 30 consecutive days. As a result, Phatra Tricholes capsule used for mice at the highest dose (19.58 g/kg b.w) did not express acute toxicity in m

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Ghareeb, Mosad A., Mansour Sobeh, Walaa H. El-Maadawy, et al. "Chemical Profiling of Polyphenolics in Eucalyptus globulus and Evaluation of Its Hepato–Renal Protective Potential Against Cyclophosphamide Induced Toxicity in Mice." Antioxidants 8, no. 9 (2019): 415. http://dx.doi.org/10.3390/antiox8090415.

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Cyclophosphamide (CP) is a potent anti-neoplastic and immunosuppressive agent; however, it causes multi-organ toxicity. We elucidated the protective activities of Eucalyptus globulus (EG) leaf extract against CP-induced hepato–renal toxicity. Mice were treated with EG for 15 days plus CP on day 12 and 13 of the experiment. Using HPLC-DAD-ESI-MS/MS, 26 secondary metabolites were identified in EG leaf extract. Out of them, 4 polyphenolic compounds were isolated: (1) 4-(O-β-d-xylopyranosyloxy)-3,5-di-hydroxy-benzoic acid, (2) 4-(O-α-l-rhamnopyranosyloxy)-3,5-di-hydroxy-benzoic acid, (3) gallic ac

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Gad El-Karim, Dina R. S., Mohamed A. Lebda, Badriyah S. Alotaibi, Attalla F. El-kott, Heba I. Ghamry, and Mustafa Shukry. "Lutein Modulates Oxidative Stress, Inflammatory and Apoptotic Biomarkers Related to Di-(2-Ethylhexyl) Phthalate (DEHP) Hepato-Nephrotoxicity in Male Rats: Role of Nuclear Factor Kappa B." Toxics 11, no. 9 (2023): 742. http://dx.doi.org/10.3390/toxics11090742.

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Phthalates are widely distributed in our environment due to their usage in many industries, especially in plastic production, which has become an essential part of daily life. This investigation aimed to assess the potential remedial influence of lutein, a naturally occurring carotenoid, on phthalate-triggered damage to the liver and kidneys. When di-(2-ethylhexyl) phthalate (DEHP) was administered to male albino rats over sixty straight days at a dosage of 200 mg/kg body weight, it resulted in a significant increase in the serum activity of liver enzymes (AST, ALT, and GGT), alpha-fetoprotein

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Ha, Tran Thai, Pham Thi Van Anh, Dao Xuan Tinh, and Dinh Thi Thu Hang. "Evaluation of acute and subchronic toxicity of “Tran Chau Nguu Hoang Hoan” in experimental animals." Tạp chí Nghiên cứu Y học 148, no. 12 (2021): 38–47. http://dx.doi.org/10.52852/tcncyh.v148i12.252.

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“Tran chau nguu hoang hoan” was prepared from 12 herbal ingredients. So far, the safety of this product, has not been reported yet. Thus, this study aimed to evaluate the acute and subchronic toxicity of “Tran chau nguu hoang hoan” through oral administration in experimental animals. The acute toxicity was determined by the method of Litchfield Wilcoxon in mice at the doses of 2.42 g/kg b.w/day to 6.04 g/kg b.w/day. The subchronic toxicity was evaluated followed the Guideline of WHO and OECD in rats with oral doses of 58.0 mg/kg b.w/day and 174.0 mg/kg b.w/day for 12 consecutive weeks. As a re

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Tung, Tran Thanh, Dau Thuy Duong, Pham Thi Thuy Minh, Nguyen Thu Hien, and Dinh Thi Thu Hang. "Evaluation of acute and subchronic toxicities of “Phuong Dong Dai Trang” tablets in experimental animals." Tạp chí Nghiên cứu Y học 141, no. 5 (2021): 29–38. http://dx.doi.org/10.52852/tcncyh.v141i5.210.

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The study aimed to evaluate the acute and subchronic toxicities of “Phuong Dong Dai Trang” tablets through oral administration using experimental animal models. Acute toxicity in Swiss mice was determined using the Litchfield Wilcoxon method. The subchronic toxicity in Wistar rats was evaluated according to WHO and OECD’s recommendation with oral doses of 4.68 g/kg/day (equivalent to recommended human dose) and 14.04 g/kg/day (3 times the recommended human dose) for 4 consecutive weeks. In terms of acute toxicity, “Phuong Dong Dai Trang” tablets did not express acute toxicity in mice at the hi

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Mrunali, Dhakare* Dr. Gopal Bihani Dr. Pavan N. Folane Dr. Kailash Biyani. "Evaluation Of In-Vivo Hepato-Protective Activity of Polyherbal Extract Against Chemically Induced-Hepatotoxic Rats." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3823–35. https://doi.org/10.5281/zenodo.15490469.

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Chemically induced hepatotoxicity in rats, also known as drug-induced liver injury (DILI), is a widely used model for studying liver damage caused by various chemicals and drugs. Researchers use this model to understand the mechanisms of hepatotoxicity, develop new therapies, and assess the safety of new drugs before they are tested in humans. Commonly used hepatotoxins in rats include Carbon Tetrachloride (CCl4), Thioacetamide (TAA), Paracetamol (Acetaminophen), D-Galactosamine, and Dimethyl nitrosamine (DMN). Histopathological and biochemical parameters are assessed through examination of li

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Pandey, C. K., A. Agarwal, A. Baronia, and N. Singh. "Toxicity of ingested formalin and its management." Human & Experimental Toxicology 19, no. 6 (2000): 360–66. http://dx.doi.org/10.1191/096032700678815954.

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Formaldehyde is a physiological intermediary metabolite taking part in many biological process in the body. It is a constituent of many items of daily use, including foods. It is also used in medicine for treatment of some conditions. A 40% solution offormaldehyde in water is known as formalin. Formalin is irritating, corrosive and toxic and absorbed from all surfaces of the body. Ingestion is rare because of alarming odour and irritant effect but documented in accidental, homicidal or suicidal attempts. Ingestion can lead to immediate deleterious effects on almost all systems of the body incl

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Kanhiya Mahour. "Multiple approach of natural hepato-protectant against chemical toxicity." World Journal of Biology Pharmacy and Health Sciences 11, no. 3 (2022): 157–66. http://dx.doi.org/10.30574/wjbphs.2022.11.3.0148.

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Plants are the major source of various ingredients which are responsible for the treatment of diseases and complications. They are used from ancient times mentioned in the Ayurveda and various Vedas because herbal medicine and their products are safe, very effective and environmental eco-friendly. They are less toxic and easily available. On the other hand, liver is the major vital organ performing major functions in the body like detoxification, biotransformation etc. It synthesizes proteins and produces biochemical’s necessary for digestion and growth. Its other roles in metabolism include t

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Ong, Simon YK, Stephen J. Clarke, James Bishop, Helen M. Dodds, and Laurent P. Rivory. "Toxicity of irinotecan (CPT-11) and hepato-renal dysfunction." Anti-Cancer Drugs 12, no. 7 (2001): 619–25. http://dx.doi.org/10.1097/00001813-200108000-00009.

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Kanhiya, Mahour. "Multiple approach of natural hepato-protectant against chemical toxicity." World Journal of Biology Pharmacy and Health Sciences 11, no. 3 (2022): 157–66. https://doi.org/10.5281/zenodo.7601986.

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Plants are the major source of various ingredients which are responsible for the treatment of diseases and complications. They are used from ancient times mentioned in the Ayurveda and various Vedas because herbal medicine and their products are safe, very effective and environmental eco-friendly. They are less toxic and easily available. On the other hand, liver is the major vital organ performing major functions in the body like detoxification, biotransformation etc. It synthesizes proteins and produces biochemical’s necessary for digestion and growth. Its other roles in metabolism inc

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Minh, Phan Hong, Tran Thi Thu Trang, Ho My Dung, et al. "Investigation of extract from jasminum subtriplinerve blume leaves for acute and subchronic oral toxicity in experimental animals." Tạp chí Nghiên cứu Y học 179, no. 6 (2024): 288–99. http://dx.doi.org/10.52852/tcncyh.v179i6.2465.

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This research is conducted to evaluate the acute and subchronic toxicities of the extract of Jasminum subtriplinvere Blume leaves through oral administration in experimental animals. The acute toxicity was determined by the Litchfield Wilcoxon method in Swiss mice. The subchronic toxicity was evaluated by WHO and OECD’s recommendation in Wistar rats with oral doses of 2.4 g/kg/day and 7.2 g/kg/day for 90 consecutive days. We found no sign of toxicity and no mortality was observed in Jasminum subtriplinvere Blume treated mice at 5000 mg/kg. In terms of the subchronic toxicity test, after oral a

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Quynh, Nguyen Thi Nhu, Dam Dinh Tranh, Dinh Thi Thu Hang, and Tran Thanh Tung. "Evaluation of acute and subchronic toxicity of An Nguyet Khang tablets in experimental animals." Tạp chí Nghiên cứu Y học 173, no. 12E13 (2023): 37–46. http://dx.doi.org/10.52852/tcncyh.v173i12e13.1815.

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The research evaluated the acute and subchronic toxicities of An Nguyet Khang tablets in experimental animals. Acute toxicity was defined by the method of Litchfield Wilcoxon in Swiss mice. The subchronic toxicity was evaluated by WHO and OECD's recommendation in Wistar rats with oral doses of 0.65 g/kg/day (equal to recommended human dose) and 1.95 g/kg/day (3 times as high as recommended human dose) in fourconsecutive weeks. We found that An Nguyet Khang tablet at the highest dose used for mice (35.15 g/kg) did not express acute toxicity in mice. Regarding the subchronic toxicity test, after

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Phu, Le Hong, Nguyen Cong Thuc, and Dinh Thi Thu Hang. "Examination of the acute and subchronic oral toxicity of “Com Kien Ty” in experimental animals." Tạp chí Nghiên cứu Y học 173, no. 12E13 (2023): 79–86. http://dx.doi.org/10.52852/tcncyh.v173i12e13.2122.

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We evaluate the acute and subchronic toxicities of “Com kien ty” through oral administration in experimental animals. The acute toxicity was determined using the Litchfield Wilcoxon method in mice. Following WHO's recommendation, the subchronic toxicity was assessed in rabbits with oral doses of 0.9 g/kg/day (equal to the recommended human dose) and 2.7 g/kg/day (3 times as high as the recommended human dose) in 4 consecutive weeks. Results showed “Com kien ty” at the highest dose of 60.0 g/kg did not express acute toxicity in mice. Regarding the subchronic toxicity test, after oral administra

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Das, D., S. Tamuly, M. Das Purkayastha, et al. "Green tea leaves extract with low concentration of EGCG can provide health benefits without causing renal damage." Acta Alimentaria 50, no. 3 (2021): 369–82. http://dx.doi.org/10.1556/066.2021.00007.

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AbstractGreen tea or its concentrated extract is coveted for its health promoting catechin-like polyphenols, especially epigallocatechin-3-gallate (EGCG). However, its amicable efficacy is now being doubted considering the recent occurrence of several cases of hepato- and nephrotoxicity, after the ingestion of EGCG-fortified (≥85–90%) nutritional supplements. Therefore, the current study was carried out to ascertain the effect of green tea leaves extract (GTE), having low EGCG content (73.8%), on liver and kidney functions of male Wistar rats using various in vivo experiments and in vitro radi

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Malekinejad, H., M. Fani, S. Kh Shafiee-Roodbari, F. Delkhosh-Kasmaie, and A. Rezaei-Golmisheh. "Crosstalk between E2f1 and c-Myc mediates hepato-protective effect of royal jelly on taxol-induced damages." Human & Experimental Toxicology 36, no. 6 (2016): 626–37. http://dx.doi.org/10.1177/0960327116660752.

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Previous histopathological studies have shown the hepatotoxicity of paclitaxel (TXL). However, there is little known about the molecular pathway(s) of TXL-induced hepatotoxicity. Therefore, this study aimed to uncover the role of two transcription factors in the TXL-induced hepatotoxicity. Moreover, the hepato-protective effect of royal jelly (RJ) on TXL-induced toxicity was investigated. Wistar rats were divided into control and test groups. The test groups along with TXL received various doses of RJ (0, 50, 100 and 150 mg/kg, body weight). Biochemical hepatic functional assays, histopatholog

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Van Anh, Pham Thi, Nguyen Van Dam, Pham Thanh Ky, Vu Viet Hang, and Dinh Thi Thu Hang. "The study of acute and subchronic toxicities of Da Dai Trang HVD capsules in experimental animals." Tạp chí Nghiên cứu Y học 148, no. 12 (2021): 7–15. http://dx.doi.org/10.52852/tcncyh.v148i12.773.

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The purpose of this research is to evaluate the acute and subchronic toxicities of DA DAI TRANG HVD capsules through oral administration in experimental animals. The acute toxicity was determined by the method of Litchfield Wilcoxon in Swiss mice. The subchronic toxicity was evaluated by the recommendation of WHO and OECD in Wistar rats with oral doses of 1.44 g/kg/day (equal to recommended human dose) and 4.32 g/kg/day (3 times as high as recommended human dose) in 4 consecutive weeks. As a result, DA DAI TRANG HVD capsules at the highest dose used for mice (99.9 g materials/kg) did not expre

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Quan, Hoang Trong, Pham Thuy Phuong, Pham Quoc Binh, Pham Thi Van Anh, and Dinh Thi Thu Hang. "Investigation of “Kien ty chi thong - HV” granules for acute and subchronic oral toxicity in experimental animals." Tạp chí Nghiên cứu Y học 166, no. 5E12 (2023): 1–10. http://dx.doi.org/10.52852/tcncyh.v166i5e12.1448.

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This research is to evaluate the acute and subchronic toxicities of “Kien ty chi thong - HV” granules through oral administration in experimental animals. The acute toxicity was determined by Litchfield Wilcoxon method in Swiss mice. The subchronic toxicity was evaluated by WHO and OECD’s recommendation in Wistar rats with oral doses of 1.8 g/kg/day (equal to recommended human dose) and 5.4 g/kg/day (3 times as high as recommended human dose) in 4 consecutive weeks. As a result, “Kien ty chi thong - HV” granules at the highest dose used in mice (56.25 g/kg) did not express acute toxicity in mi

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Boulila, Salha, Kais Mnafgui, Hassane Oudadesse, Hafed El Feki, and Abdelfattah El Feki. "Comparison of three types of physical aspects of a carbonated hydroxyapatite biomaterial: Study implantaion in vivo in rats of "Wistar" strain and physiological & physicochemical explorations." JOURNAL OF ADVANCES IN CHEMISTRY 8, no. 2 (2012): 1612–29. http://dx.doi.org/10.24297/jac.v8i2.4042.

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Currently, research on biomaterials must meet and demonstrate a set of therapeutic competence to level many health problems. The objective of our work is to normalize the technique of implantation of the biomaterial (carbonated hydroxyapatite: HAC). Three modes subcutaneous implantation was carried out. This technique consists to select the most tolerated by the body without toxicity. Thus, we have applied our biomaterial (HAC) in pellet form under pressure, under pressure sintering pellets and capsules for two weeks. Our results showed that the capsule did not disturb and mainted the equilibr

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Bintu, Babagana, and O. Sadiq Lukman. "Effect of Moringa oleifera Crude Leaf Extract on Chlorpyriphos-induced Hepato-Toxicity in Wistar Albino Rats." Pharmaceutical and Chemical Journal 5, no. 3 (2018): 15–19. https://doi.org/10.5281/zenodo.13905105.

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The effect of <em>Moringa oleifera</em> crude leaf extract on Chlorpyriphos-induced hepato-toxicity in Wistar albino rats was investigated. Sixteen (16) adult Wistar albino rats of weighing about 100g and 250g were divided into a group of four (4) of four (4) rats each. Group I served as the control and were given a standard feed while groups II, III and IV were given 200mg/kg, 100mg/kg and 100mg/kg of the feed respectively following different treatments with Moringa and Chlorpyriphos. All feed were administered in pelleted form for a period of 28days. On the 29th day, the animals were humanel

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Nair, Cherupally KrishnanKrishnan, R. Indu, TS Azhar, and Arathy Nair. "Amelioration of doxorubicin induced cardio-and hepato-toxicity by carotenoids." Journal of Cancer Research and Therapeutics 10, no. 1 (2014): 62. http://dx.doi.org/10.4103/0973-1482.131370.

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El-Moselhy, Mohamed A., and Azza A. K. El-Sheikh. "Protective mechanisms of atorvastatin against doxorubicin-induced hepato-renal toxicity." Biomedicine & Pharmacotherapy 68, no. 1 (2014): 101–10. http://dx.doi.org/10.1016/j.biopha.2013.09.001.

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Inselmann, G., U. Lawerenz, and H. Heidemann. "Enhancement of cyclosporin a induced hepato-toxicity by glutathione depletion." Journal of Hepatology 13 (January 1991): S133. http://dx.doi.org/10.1016/0168-8278(91)91505-b.

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Reddy, P. Malla, and G. H. Philip. "Hepato Toxicity of Malathion on the Protein Metabolism inCyprinus carpio." Acta Hydrochimica et Hydrobiologica 19, no. 1 (1991): 127–30. http://dx.doi.org/10.1002/aheh.19910190115.

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Paul, Subhankar, and Priyankar Pal. "Benzene-mediated hepato-toxicity: A review of the underlying mechanisms." International Journal of Hepatology Research 6, no. 1 (2024): 01–03. http://dx.doi.org/10.33545/26646595.2024.v6.i1a.3.

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Lee, Victor HF, Weijia Fang, Ka On Lam, et al. "Capecitabine but not 5-FU worsened hepatosplenomegaly and liver function when used with oxaliplatin and cetuximab as first-line treatment in K-ras wild-type metastatic colorectal cancer." Journal of Clinical Oncology 31, no. 15_suppl (2013): e14530-e14530. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e14530.

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e14530 Background: MRC COIN study showed that OXA and CAP (CAPOX) have greater toxicities compared with OXA and 5-FU (FOLFOX) when cetuximab (C225) was added for mCRC. Meanwhile, OXA was associated with splenomegaly and hepatic sinusoidal injury. We investigated if CAPOX+C225 worsened hepatosplenomegaly and liver function compared with FOLFOX+C225 in K-rasWT mCRC. Methods: 97 patients with K-ras WT mCRC received either FOLFOX or CAPOX (n=57) or the same regimen+C225 (n=40) as 1st line treatment. CT scan of abdomen was performed at baseline and then after every 3-4 cycles. Liver excluding liver

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Ammar, Naglaa M., Heba A. Hassan, Heba M. I. Abdallah, et al. "Protective Effects of Naringenin from Citrus sinensis (var. Valencia) Peels against CCl4-Induced Hepatic and Renal Injuries in Rats Assessed by Metabolomics, Histological and Biochemical Analyses." Nutrients 14, no. 4 (2022): 841. http://dx.doi.org/10.3390/nu14040841.

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Citrus fruits are grown worldwide for their special nutritive and several health benefits. Among citrus bioactives, naringenin, a major flavanone, exhibits a potential hepatoprotective effect that is not fully elucidated. Herein, serum biochemical parameters and histopathological assays were used to estimate the hepatoprotective activity of naringenin, isolated from Citrus sinensis (var. Valencia) peels, in CCl4-induced injury in a rat model. Further, GC–MS-based untargeted metabolomics was used to characterize the potential metabolite biomarkers associated with its activity. Present results r

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