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Journal articles on the topic 'HES6'

Author: Grafiati

Published: 4 June 2021

Last updated: 17 February 2022

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1

Kuang, Shaoqing, Patrick Zweidler-McKay, Hui Yang, Zhi Hong Fang, Weigang Tong, and Guillermo Garcia-Manero. "Epigenetic Inactivation of Notch Signaling Target Genes HES in B Cell Acute Lymphoblastic Leukemia." Blood 112, no. 11 (2008): 3372. http://dx.doi.org/10.1182/blood.v112.11.3372.3372.

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Abstract The Notch signaling pathway has been implicated in multiple functions during normal hemato-lymphoid development. It also plays critical roles in T-cell leukemogenesis through influencing T-cell proliferation, differentiation and survival. In contrast, we have previously reported a tumor suppressor role in B-cell leukemias, where Notch signaling leads to growth inhibition and apoptosis. The Notch target genes Hairy/Enhancer of Split (HES1-7) encode transcriptional repressors with basic helix-loop-helix (bHLH) domains. Functional and phenotypic analyses of some of the HES family members

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2

Gratton, Michel-Olivier, Elena Torban, Stephanie Belanger Jasmin, Francesca M. Theriault, Michael S. German, and Stefano Stifani. "Hes6 Promotes Cortical Neurogenesis and Inhibits Hes1 Transcription Repression Activity by Multiple Mechanisms." Molecular and Cellular Biology 23, no. 19 (2003): 6922–35. http://dx.doi.org/10.1128/mcb.23.19.6922-6935.2003.

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ABSTRACT Hes1 is a mammalian basic helix-loop-helix transcriptional repressor that inhibits neuronal differentiation together with corepressors of the Groucho (Gro)/Transducin-like Enhancer of split (TLE) family. The interaction of Hes1 with Gro/TLE is mediated by a WRPW tetrapeptide present in all Hairy/Enhancer of split (Hes) family members. In contrast to Hes1, the related protein Hes6 promotes neuronal differentiation. Little is known about the molecular mechanisms that underlie the neurogenic activity of Hes6. It is shown here that Hes6 antagonizes Hes1 function by two mechanisms. Hes6 in

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3

Bae, S., Y. Bessho, M. Hojo, and R. Kageyama. "The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation." Development 127, no. 13 (2000): 2933–43. http://dx.doi.org/10.1242/dev.127.13.2933.

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We have isolated the basic helix-loop-helix (bHLH) gene Hes6, a novel member of the family of mammalian homologues of Drosophila hairy and Enhancer of split. Hes6 is expressed by both undifferentiated and differentiated cells, unlike Hes1, which is expressed only by the former cells. Hes6 alone does not bind to the DNA but suppresses Hes1 from repressing transcription. In addition, Hes6 suppresses Hes1 from inhibiting Mash1-E47 heterodimer and thereby enables Mash1 and E47 to upregulate transcription in the presence of Hes1. Furthermore, misexpression of Hes6 with retrovirus in the developing

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4

Cossins, Judy, Ann E. Vernon, Yun Zhang, Anna Philpott, and Philip H. Jones. "Hes6 regulates myogenic differentiation." Development 129, no. 9 (2002): 2195–207. http://dx.doi.org/10.1242/dev.129.9.2195.

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Hes6 is a basic helix-loop-helix transcription factor homologous to Drosophila Enhancer of Split (EoS) proteins. It is known to promote neural differentiation and to bind to Hes1, a related protein that is part of the Notch signalling pathway, affecting Hes1-regulated transcription. We show that Hes6 is expressed in the murine embryonic myotome and is induced on C2C12 myoblast differentiation in vitro. Hes6 binds DNA containing the Enhancer of Split E box (ESE) motif, the preferred binding site of Drosophila EoS proteins, and represses transcription of an ESE box reporter. When overexpressed i

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5

Gao, Xiangming, Tanya Chandra, Michel-Olivier Gratton, et al. "HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program." Journal of Cell Biology 154, no. 6 (2001): 1161–72. http://dx.doi.org/10.1083/jcb.200104058.

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HES6 is a novel member of the family of basic helix–loop–helix mammalian homologues of Drosophila Hairy and Enhancer of split. We have analyzed the biochemical and functional roles of HES6 in myoblasts. HES6 interacted with the corepressor transducin-like Enhancer of split 1 in yeast and mammalian cells through its WRPW COOH-terminal motif. HES6 repressed transcription from an N box–containing template and also when tethered to DNA through the GAL4 DNA binding domain. On N box–containing promoters, HES6 cooperated with HES1 to achieve maximal repression. An HES6–VP16 activation domain fusion p

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6

Katakura, Masanori, Michio Hashimoto, Toshiyuki Okui, Hossain Md Shahdat, Kentaro Matsuzaki, and Osamu Shido. "Omega-3 Polyunsaturated Fatty Acids Enhance Neuronal Differentiation in Cultured Rat Neural Stem Cells." Stem Cells International 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/490476.

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Polyunsaturated fatty acids (PUFAs) can induce neurogenesis and recovery from brain diseases. However, the exact mechanisms of the beneficial effects of PUFAs have not been conclusively described. We recently reported that docosahexaenoic acid (DHA) induced neuronal differentiation by decreasing Hes1 expression and increasingp27kip1expression, which causes cell cycle arrest in neural stem cells (NSCs). In the present study, we examined the effect of eicosapentaenoic acid (EPA) and arachidonic acid (AA) on differentiation, expression of basic helix-loop-helix transcription factors (Hes1, Hes6,

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7

Lee, Jiwon, Sung Kook Chun, Gi Hoon Son, and Kyungjin Kim. "Sumoylation of Hes6 Regulates Protein Degradation and Hes1-Mediated Transcription." Endocrinology and Metabolism 30, no. 3 (2015): 381. http://dx.doi.org/10.3803/enm.2015.30.3.381.

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8

Jacobsen, K., and P. Albert. "[P120]: Coordinated actions of Hes1, Hes5, Hes6 and NUDR on 5‐HT1A transcription at a functional polymorphism." International Journal of Developmental Neuroscience 24, no. 8 (2006): 547. http://dx.doi.org/10.1016/j.ijdevneu.2006.09.182.

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9

Luca, Bogdan-Alexandru, Vincent Moulton, Christopher Ellis, Shea P. Connell, Daniel S. Brewer, and Colin S. Cooper. "Convergence of Prognostic Gene Signatures Suggests Underlying Mechanisms of Human Prostate Cancer Progression." Genes 11, no. 7 (2020): 802. http://dx.doi.org/10.3390/genes11070802.

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The highly heterogeneous clinical course of human prostate cancer has prompted the development of multiple RNA biomarkers and diagnostic tools to predict outcome for individual patients. Biomarker discovery is often unstable with, for example, small changes in discovery dataset configuration resulting in large alterations in biomarker composition. Our hypothesis, which forms the basis of this current study, is that highly significant overlaps occurring between gene signatures obtained using entirely different approaches indicate genes fundamental for controlling cancer progression. For prostat

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10

Cossins, J., AE Vernon, Y. Zhang, A. Philpott, and PH Jones. "Hes6 Regulates Myogenic Differentiation." Clinical Science 103, s47 (2002): 44P. http://dx.doi.org/10.1042/cs103044pa.

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11

Martinez-Jimenez, Celia Pilar, Irene Kyrmizi, Philippe Cardot, Frank J. Gonzalez та Iannis Talianidis. "Hepatocyte Nuclear Factor 4α Coordinates a Transcription Factor Network Regulating Hepatic Fatty Acid Metabolism". Molecular and Cellular Biology 30, № 3 (2009): 565–77. http://dx.doi.org/10.1128/mcb.00927-09.

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ABSTRACT Adaptation of liver to nutritional signals is regulated by several transcription factors that are modulated by intracellular metabolites. Here, we demonstrate a transcription factor network under the control of hepatocyte nuclear factor 4α (HNF4α) that coordinates the reciprocal expression of fatty acid transport and metabolizing enzymes during fasting and feeding conditions. Hes6 is identified as a novel HNF4α target, which in normally fed animals, together with HNF4α, maintains PPARγ expression at low levels and represses several PPARα-regulated genes. During fasting, Hes6 expressio

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12

Salama-Cohen, Patricia, María-Ángeles Arévalo, Jochen Meier, Rosemarie Grantyn, and Alfredo Rodríguez-Tébar. "NGF Controls Dendrite Development in Hippocampal Neurons by Binding to p75NTR and Modulating the Cellular Targets of Notch." Molecular Biology of the Cell 16, no. 1 (2005): 339–47. http://dx.doi.org/10.1091/mbc.e04-05-0438.

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Notch and neurotrophins control neuronal shape, but it is not known whether their signaling pathways intersect. Here we report results from hippocampal neuronal cultures that are in support of this possibility. We found that low cell density or blockade of Notch signaling by a soluble Delta-Fc ligand decreased the mRNA levels of the nuclear targets of Notch, the homologues of enhancer-of-split 1 and 5 (Hes1/5). This effect was associated with enhanced sprouting of new dendrites or dendrite branches. In contrast, high cell density or exposure of low-density cultures to NGF increased the Hes1/5

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13

Vilas-Boas, Filipe, and Domingos Henrique. "HES6-1 and HES6-2 Function through Different Mechanisms during Neuronal Differentiation." PLoS ONE 5, no. 12 (2010): e15459. http://dx.doi.org/10.1371/journal.pone.0015459.

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14

Koyano-Nakagawa, N., J. Kim, D. Anderson, and C. Kintner. "Hes6 acts in a positive feedback loop with the neurogenins to promote neuronal differentiation." Development 127, no. 19 (2000): 4203–16. http://dx.doi.org/10.1242/dev.127.19.4203.

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During the development of the vertebrate nervous system, neurogenesis is promoted by proneural bHLH proteins such as the neurogenins, which act as potent transcriptional activators of neuronal differentiation genes. The pattern by which these proteins promote neuronal differentiation is thought to be governed by inhibitors, including a class of transcriptional repressors called the WRPW-bHLH proteins, which are similar to Drosophila proteins encoded by hairy and genes in the enhancer of split complex (E-(SPL)-C). Here, we describe the isolation and characterization of Hes6, which encodes a nov

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15

Fior, Rita, and Domingos Henrique. "A novel hes5/hes6 circuitry of negative regulation controls Notch activity during neurogenesis." Developmental Biology 281, no. 2 (2005): 318–33. http://dx.doi.org/10.1016/j.ydbio.2005.03.017.

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16

Yamamoto, Takanori, Atsushi Kamijo, Tadao Nakazawa, et al. "A Very Rare Case of Hypereosinophilic Syndrome Secondary to Natural Killer/T-Cell Lymphoma." Case Reports in Otolaryngology 2018 (2018): 1–4. http://dx.doi.org/10.1155/2018/5965029.

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Hypereosinophilic syndrome (HES) is a systemic disease characterized by an increased peripheral blood eosinophil count accompanied by systemic organ dysfunction. HES is classified into idiopathic HES, primary (neoplastic) HES (HESN), and secondary (reactive) HES (HESR). In this case report, a patient who developed peripheral blood eosinophilia and granulation tissue in the pharynx and paranasal sinus, which was initially diagnosed as chronic eosinophilic leukemia (CEL), categorized as HESN, but was eventually identified after the patient had died as natural killer/T-cell (NK/T) lymphoma, nasal

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17

Lee, Yeon-Ju, Dong-Hee Han, Youngmi Kim Pak, and Sehyung Cho. "Circadian regulation of low density lipoprotein receptor promoter activity by CLOCK/BMAL1, Hes1 and Hes6." Experimental & Molecular Medicine 44, no. 11 (2012): 642. http://dx.doi.org/10.3858/emm.2012.44.11.073.

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18

Hasyim, Djatun, Ratn Samodro, Himawan Sasongko, and Ery Leksana. "Perbedaan Pengaruh HES 6% (200) Dalam NaCl 0,9% dan Dalam Larutan Berimbang pada Base Excess dan Strong Ion Difference Pasien Seksio Sesaria dengan Anestesi Spinal." JAI (Jurnal Anestesiologi Indonesia) 5, no. 2 (2013): 83. http://dx.doi.org/10.14710/jai.v5i2.6410.

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Latar belakang : Pada bedah sesar dengan anestesi spinal, pemilihan koloid sebagaicairan preload lebih efektif ketimbang kristaloid. Pemberian cairan koloid denganpelarut yang berbeda sebagai preload ini memiliki dampak terhadap keseimbanganasam basa tubuh. Sehingga pemilihan koloid berdasarkan pelarutnya mulaidipertimbangkan.Tujuan : Melihat pengaruh pemberian HES 6% dalam larutan berimbang dengan HES6% dalam NaC1 0,9% terhadap Base Excess (BE) dan Strong Ion Difference (SID)pada pasien bedah sesar dengan anestesi spinal.Metode : Merupakan uji klinik eksperimental yang dilakukan secara acak t

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19

Xu, Ying-Chen, Chao-Jie Liang, Dong-Xin Zhang, et al. "LncSHRG promotes hepatocellular carcinoma progression by activating HES6." Oncotarget 8, no. 41 (2017): 70630–41. http://dx.doi.org/10.18632/oncotarget.19906.

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20

Wickramasinghe, Caroline M., Renae Domaschenz, Yoko Amagase, et al. "HES6 enhances the motility of alveolar rhabdomyosarcoma cells." Experimental Cell Research 319, no. 1 (2013): 103–12. http://dx.doi.org/10.1016/j.yexcr.2012.08.010.

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21

Murai, Kasumi, Ann E. Vernon, Anna Philpott, and Phil Jones. "Hes6 is required for MyoD induction during gastrulation." Developmental Biology 312, no. 1 (2007): 61–76. http://dx.doi.org/10.1016/j.ydbio.2007.09.011.

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22

Lamb, Alastair D., Antonio Ramos-Montoya, Roslin Russell, et al. "Role of Hes6 in castration-resistant prostate cancer." Lancet 383 (February 2014): S67. http://dx.doi.org/10.1016/s0140-6736(14)60330-5.

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23

Bauer, Simone, Leonie Ratz, Doreen Heckmann-Nötzel, et al. "miR-449a Repression Leads to Enhanced NOTCH Signaling in TMPRSS2:ERG Fusion Positive Prostate Cancer Cells." Cancers 13, no. 5 (2021): 964. http://dx.doi.org/10.3390/cancers13050964.

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About 50% of prostate cancer (PCa) tumors are TMPRSS2:ERG (T2E) fusion-positive (T2E+), but the role of T2E in PCa progression is not fully understood. We were interested in investigating epigenomic alterations associated with T2E+ PCa. Using different sequencing cohorts, we found several transcripts of the miR-449 cluster to be repressed in T2E+ PCa. This repression correlated strongly with enhanced expression of NOTCH and several of its target genes in TCGA and ICGC PCa RNA-seq data. We corroborated these findings using a cellular model with inducible T2E expression. Overexpression of miR-44

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24

Carvalho, Filipe L. F., Luigi Marchionni, Anuj Gupta, et al. "HES6 promotes prostate cancer aggressiveness independently of Notch signalling." Journal of Cellular and Molecular Medicine 19, no. 7 (2015): 1624–36. http://dx.doi.org/10.1111/jcmm.12537.

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25

Kang, Seon Ah, Jae Hong Seol, and Jaesang Kim. "The conserved WRPW motif of Hes6 mediates proteasomal degradation." Biochemical and Biophysical Research Communications 332, no. 1 (2005): 33–36. http://dx.doi.org/10.1016/j.bbrc.2005.04.089.

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26

Guiu, Jordi, Ritsuko Shimizu, Teresa D’Altri, et al. "Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling." Journal of Experimental Medicine 210, no. 1 (2012): 71–84. http://dx.doi.org/10.1084/jem.20120993.

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Previous studies have identified Notch as a key regulator of hematopoietic stem cell (HSC) development, but the underlying downstream mechanisms remain unknown. The Notch target Hes1 is widely expressed in the aortic endothelium and hematopoietic clusters, though Hes1-deficient mice show no overt hematopoietic abnormalities. We now demonstrate that Hes is required for the development of HSC in the mouse embryo, a function previously undetected as the result of functional compensation by de novo expression of Hes5 in the aorta/gonad/mesonephros (AGM) region of Hes1 mutants. Analysis of embryos

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27

Massie, Charles E., Inmaculada Spiteri, Helen Ross-Adams, et al. "HES5 silencing is an early and recurrent change in prostate tumourigenesis." Endocrine-Related Cancer 22, no. 2 (2015): 131–44. http://dx.doi.org/10.1530/erc-14-0454.

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Prostate cancer is the most common cancer in men, resulting in over 10 000 deaths/year in the UK. Sequencing and copy number analysis of primary tumours has revealed heterogeneity within tumours and an absence of recurrent founder mutations, consistent with non-genetic disease initiating events. Using methylation profiling in a series of multi-focal prostate tumours, we identify promoter methylation of the transcription factorHES5as an early event in prostate tumourigenesis. We confirm that this epigenetic alteration occurs in 86–97% of cases in two independent prostate cancer cohorts (n=49 an

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28

Cau, E., G. Gradwohl, S. Casarosa, R. Kageyama, and F. Guillemot. "Hes genes regulate sequential stages of neurogenesis in the olfactory epithelium." Development 127, no. 11 (2000): 2323–32. http://dx.doi.org/10.1242/dev.127.11.2323.

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We have characterised the functions of the bHLH transcriptional repressors HES1 and HES5 in neurogenesis, using the development of the olfactory placodes in mouse embryos as a model. Hes1 and Hes5 are expressed with distinct patterns in the olfactory placodes and are subject to different regulatory mechanisms. Hes1 is expressed in a broad placodal domain, which is maintained in absence of the neural determination gene Mash1. In contrast, expression of Hes5 is restricted to clusters of neural progenitor cells and requires Mash1 function. Mutations in Hes1 and Hes5 also have distinct consequence

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29

Carvalho, L., and M. Berman. "656 HES6 interacts with Notch signaling in prostate cancer progression." European Urology Supplements 11, no. 1 (2012): e656-e656a. http://dx.doi.org/10.1016/s1569-9056(12)60653-8.

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30

Annala, Matti, Kati Kivinummi, Katri Leinonen, et al. "DOT1L‐HES6 fusion drives androgen independent growth in prostate cancer." EMBO Molecular Medicine 6, no. 9 (2014): 1121–23. http://dx.doi.org/10.15252/emmm.201404210.

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31

Jhas, S., S. Ciura, S. Belanger-Jasmin, et al. "Hes6 Inhibits Astrocyte Differentiation and Promotes Neurogenesis through Different Mechanisms." Journal of Neuroscience 26, no. 43 (2006): 11061–71. http://dx.doi.org/10.1523/jneurosci.1358-06.2006.

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32

Malone, Caroline M. P., Renae Domaschenz, Yoko Amagase, Ian Dunham, Kasumi Murai, and Philip H. Jones. "Hes6 is required for actin cytoskeletal organization in differentiating C2C12 myoblasts." Experimental Cell Research 317, no. 11 (2011): 1590–602. http://dx.doi.org/10.1016/j.yexcr.2011.03.023.

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33

Murai, Kasumi, Anna Philpott, and Philip H. Jones. "Hes6 Is Required for the Neurogenic Activity of Neurogenin and NeuroD." PLoS ONE 6, no. 11 (2011): e27880. http://dx.doi.org/10.1371/journal.pone.0027880.

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34

Ball, Andrew J., Annelie E. Abrahamsson, Björn Tyrberg, Pamela Itkin-Ansari, and Fred Levine. "HES6 reverses nuclear reprogramming of insulin-producing cells following cell fusion." Biochemical and Biophysical Research Communications 355, no. 2 (2007): 331–37. http://dx.doi.org/10.1016/j.bbrc.2007.01.153.

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35

Kita, Aya, Itaru Imayoshi, Masato Hojo, et al. "Hes1 and Hes5 Control the Progenitor Pool, Intermediate Lobe Specification, and Posterior Lobe Formation in the Pituitary Development." Molecular Endocrinology 21, no. 6 (2007): 1458–66. http://dx.doi.org/10.1210/me.2007-0039.

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Abstract The pituitary gland is composed of two distinct entities: the adenohypophysis, including the anterior and intermediate lobes, and the neurohypophysis, known as the posterior lobe. This critical endocrine organ is essential for homeostasis, metabolism, reproduction, and growth. The pituitary development requires the control of proliferation and differentiation of progenitor cells. Although multiple signaling molecules and transcription factors are required for the proper pituitary development, the mechanisms that regulate the fate of progenitor cells remain to be elucidated. Hes genes,

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36

Zhang, Jing-Wen, Ru Yan, Yu-Sheng Tang, et al. "Hyperhomocysteinemia-induced autophagy and apoptosis with downregulation of hairy enhancer of split 1/5 in cortical neurons in mice." International Journal of Immunopathology and Pharmacology 30, no. 4 (2017): 371–82. http://dx.doi.org/10.1177/0394632017740061.

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It has been reported that hyperhomocysteinemia (HHcy) is associated with neurodegenerative and cardiovascular diseases. However, little is known about brain histomorphology, neuronal organelles, and hairy enhancer of split ( hes) expression under HHcy. In this study, non-HHcy and HHcy induced by high-methionine diet in apolipoprotein E–deficient (Apo E−/−) mice were comparatively investigated. The histomorphology, ultrastructure, autophagosomes, apoptosis, and expression of proteins, HES1, HES5 and P62, were designed to assess the effects of HHcy on brain. The results showed that compared to t

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37

Carvalho, F. L., L. Marchionni, A. Gupta, et al. "847 HES6 promotes prostate cancer aggressiveness and is independent of Notch signalling." European Urology Supplements 13, no. 1 (2014): e847. http://dx.doi.org/10.1016/s1569-9056(14)60834-4.

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38

Eun, Bokkee, Bongki Cho, Younghye Moon, et al. "Induction of neuronal apoptosis by expression of Hes6 via p53-dependent pathway." Brain Research 1313 (February 2010): 1–8. http://dx.doi.org/10.1016/j.brainres.2009.11.078.

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39

Vilas‐Boas, F., and D. Henrique. "[P1.57]: Two hes6 genes in the chick with different functions during embryonic development." International Journal of Developmental Neuroscience 28, no. 8 (2010): 674. http://dx.doi.org/10.1016/j.ijdevneu.2010.07.097.

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40

De Decker, Matthias, Marieke Lavaert, Juliette Roels, et al. "HES1 and HES4 have non-redundant roles downstream of Notch during early human T-cell development." Haematologica 106, no. 1 (2020): 130–41. http://dx.doi.org/10.3324/haematol.2019.226126.

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In both mouse and human, Notch1 activation is the main initial driver to induce T-cell development in hematopoietic progenitor cells. The initiation of this developmental process coincides with Notch1-dependent repression of differentiation towards other hematopoietic lineages. Although well described in mice, the role of the individual Notch1 target genes during these hematopoietic developmental choices is still unclear in human, particularly for HES4 since no orthologous gene is present in the mouse. Here, we investigated the functional capacity of the Notch1 target genes HES1 and HES4 to mo

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41

Suzuki, Y. "Expression of Hes6 and NeuroD in the Olfactory Epithelium, Vomeronasal Organ and Non-sensory Patches." Chemical Senses 28, no. 3 (2003): 197–205. http://dx.doi.org/10.1093/chemse/28.3.197.

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42

Methot, L., R. Hermann, Y. Tang, et al. "Interaction and Antagonistic Roles of NF- B and Hes6 in the Regulation of Cortical Neurogenesis." Molecular and Cellular Biology 33, no. 14 (2013): 2797–808. http://dx.doi.org/10.1128/mcb.01610-12.

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43

Scheffer, Deborah, Cyrille Sage, David P. Corey, and Veronique Pingault. "Gene expression profiling identifies Hes6 as a transcriptional target of ATOH1 in cochlear hair cells." FEBS Letters 581, no. 24 (2007): 4651–56. http://dx.doi.org/10.1016/j.febslet.2007.08.059.

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44

Liu, J., F. Ye, H. Chen, W. LÜ, C. Zhou, and X. Xie. "Expression of differentiation associated protein Hes1 and Hes5 in cervical squamous carcinoma and its precursors." International Journal of Gynecologic Cancer 17, no. 6 (2007): 1293–99. http://dx.doi.org/10.1111/j.1525-1438.2007.00930.x.

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Hairy and Enhancer-of-split homologues 1 and 5 (Hes1 and Hes5) are the basic helix-loop-helix transcriptional factors that negatively regulate the cell differentiation during embryogenesis. It has been reported that they may be involved in carcinogenesis in some tumors. The roles of Hes1 and Hes5 in development and progression of cervical carcinoma are not well documented todate. In the study, the expression of Hes1 and Hes5 were detected by immunohistochemistry in 295 cases with various degrees of cervical epithelial lesions, including 78 normal cervical epithelia, 31 mild dysplasia (CIN I),

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45

Pissarra, Luı́sa, Domingos Henrique, and António Duarte. "Expression of hes6 , a new member of the Hairy/Enhancer-of-split family, in mouse development." Mechanisms of Development 95, no. 1-2 (2000): 275–78. http://dx.doi.org/10.1016/s0925-4773(00)00348-8.

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46

Haapa-Paananen, S., S. Kiviluoto, M. Waltari, et al. "HES6 gene is selectively overexpressed in glioma and represents an important transcriptional regulator of glioma proliferation." Oncogene 31, no. 10 (2011): 1299–310. http://dx.doi.org/10.1038/onc.2011.316.

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47

Qian, Dong, Kristen Radde-Gallwitz, Michael Kelly, et al. "Basic helix–loop–helix gene Hes6 delineates the sensory hair cell lineage in the inner ear." Developmental Dynamics 235, no. 6 (2006): 1689–700. http://dx.doi.org/10.1002/dvdy.20736.

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48

Trofka, A., J. Schwendinger-Schreck, T. Brend, W. Pontius, T. Emonet, and S. A. Holley. "The Her7 node modulates the network topology of the zebrafish segmentation clock via sequestration of the Hes6 hub." Development 139, no. 5 (2012): 940–47. http://dx.doi.org/10.1242/dev.073544.

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Belanger-Jasmin, Stephanie, Estelle Llamosas, Yeman Tang, et al. "Inhibition of cortical astrocyte differentiation by Hes6 requires amino- and carboxy-terminal motifs important for dimerization and phosphorylation." Journal of Neurochemistry 103, no. 5 (2007): 2022–34. http://dx.doi.org/10.1111/j.1471-4159.2007.04902.x.

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Seta, Yuji, Cristi L. Stoick-Cooper, Takashi Toyono, Shinji Kataoka, Kuniaki Toyoshima, and Linda A. Barlow. "The bHLH transcription factors, Hes6 and Mash1, are expressed in distinct subsets of cells within adult mouse taste buds." Archives of Histology and Cytology 69, no. 3 (2006): 189–98. http://dx.doi.org/10.1679/aohc.69.189.

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