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Dissertations / Theses on the topic 'Heterocycles Fused'

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Published: 5 June 2025

Last updated: 1 August 2025

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1

Stevenson, Elizabeth. "Pyrolytic syntheses of fused bridgehead nitrogen heterocycles." Thesis, University of Edinburgh, 1999. http://hdl.handle.net/1842/13016.

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There are two distinct areas of work in this thesis, both involving pyrolytic syntheses of nitrogen heterocycles. The first area of work extends a previous synthesis of 1<I>H</I>-azepin-3(2<I>H</I>)-ones to examples with a fused ring in the 1,2-position. The synthetic strategy for such azepinones involved preparation of enaminals incorporating cyclic amines with different ring sizes, then condensation of the enaminals with Meldrum's acid (2,2-dimethyl-1,3-dioxane-4,6-dione). Flash Vacuum Pyrolysis (F.V.P.) of the Meldrum's acid derivative gave the fused azepinone with dicyclopentadienone forme

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2

Fletcher, Rodney Justin. "Radical cyclisation in routes to cis-fused heterocycles." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283701.

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3

Hitchings, G. J. "The synthesis of fused heterocycles containing bridgehead-nitrogen." Thesis, University of York, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383838.

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4

Tyas, Richard G. "New pyrolytic routes to fused bridgehead nitrogen heterocycles." Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/11477.

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Under flash vacuum pyrolysis (FVP) conditions <i>C-</i>unsubstituted imidazole <i>N-</i>propenoate ester derivatives give 78±5:22±5 mixtures of pyrrolo[1,2-<i>a</i>]amidazol-5-one and pyrrolo[1,2<i>-c</i>]imidazol-5-ones. The mechanism involves a cascade process initiated by 1,5-sigmatropic shift of the substituent. Substitution of the imidazole <i>N</i>-propenoate ester at the 2-position or 4,5-positons of the heterocycle allows exclusive access to the pyrrolo[1,2-<i>c</i>]imidazol-5-one and pyrrolo[1,2-<i>a</i>]amidazol-5-one systems respectively upon FVP. Ring-opening of the pyrrolo[1,2-<i>

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5

Ergun, Merve. "Development Of New Synthetic Methodologies For Furan Fused Heterocycles." Master's thesis, METU, 2013. http://etd.lib.metu.edu.tr/upload/12615337/index.pdf.

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Furopyranones and furopyrrolones are furan-fused bicyclic heterocycles containing pyranone and pyrrolone framework respectively. Many natural products and pharmaceutical agents include these core structures. In this study, new synthetic methodologies were developed for the synthesis of furopyranone and furopyrrolone derivatives. In the first section of this thesis, methyl 2-(2-methoxy-2-oxoethyl)-3-furoate was hydrolyzed forming 2-(carboxymethyl)-3-furoic acid which underwent intramolecular cyclization reaction using two different methodologies forming furopyranone derivatives. In the second p

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6

Tice, Nathan Charles. "THE SYNTHESIS, STRUCTURE, AND REACTIVITY OF SOME ORGANOMETALLIC-FUSED HETEROCYCLES." UKnowledge, 2006. http://uknowledge.uky.edu/gradschool_diss/297.

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The synthesis, structure, and reactivity of some organometallic-fusedheterocycles were studied. This work was divided into three parts: first,thiapentalenyl tricarbonyl manganese complexes [Mn(CO)3{??5-SC7H3-1,3-(R)2}]were synthesized employing thiation on diacyl precursors; second, attempts toform the 5,5-fused ring pyrrole analogs to the thiapentalenyl complexes led to theformation of various amine and imine ligands and manganese complexes, but notthe desired ring-closed pyrroles; third, reductive amination on a ferrocenylmonoaldehyde substrate led to the formation of di(N-(ferrocenylmethyl)

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7

Sadiq, Samina. "Studies of some fused-ring heterocycles and 2,6-Diarylpyridine derivatives." Thesis, Brunel University, 1999. http://bura.brunel.ac.uk/handle/2438/7281.

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This work reported is divided into two parts: the first part deals with quinoxaline derivatives and includes the preparation and characterisation of novel linear tricyclic quinones 1,4-diazanthracen-9,10-diones, (54) and (55). The reaction of diazanaphthoquinones and 1-acetyl-1,3-butadiene are used to produce these quinones through the Diels-Alder reaction. In addition hexaazapentacyclic 5,6,7,12,13, 14-hexaazapentacene was prepared by the reaction ofbis(2-chloroquinoxalin-3-yl)sulfide with thioxamide and the reaction of the sulfide with amines was investigated. Two different approaches to 6,1

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8

Ladwa, Mitesh Mohan. "A radical approach towards the synthesis of fused nitrogen heterocycles." Thesis, University of Aberdeen, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430405.

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A literature review of the chemistry of homolytic aromatic substitution is presented with particular emphasis to the formation of fused heterocyclic systems. A series of five-membered spirocyclic 5-azaoxindole-ring systems have been synthesised by generating an alkyl radical that underwent an intramolecular radical cyclisation at the 3-positon of a pyridine ring and was followed by oxidation giving rise to a mix of fused pyridine ring systems. However, numerous problems were encountered with this investigation, not least the stability of the alpha brominated carbonyl radical precursor, conseq

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9

Boyle, Rosemary. "Synthesis, structure and stereochemistry of metabolites from benzo-fused oxygen heterocycles." Thesis, Queen's University Belfast, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333789.

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10

Torrisi, Elena. "Intramolecular 1,3 dipolar cycloaddition: a powerful tool to synthetize fused heterocycles." Doctoral thesis, Urbino, 2021. http://hdl.handle.net/11576/2689496.

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11

Bell, Ian Alexander Weston. "Investigations of new synthetic routes to fused tricyclic heteropines and related heterocycles." Thesis, University of Edinburgh, 1996. http://hdl.handle.net/1842/13851.

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The subject matter of this thesis is concerned with investigations into the synthesis of tricyclic heteropine systems. In particular Lewis acid-catalysed and carbanion-induced cyclisation reactions of suitably substituted isothiocyanate and carbodiimide derivatives were investigated for the synthesis of dibenzoxazepines, pyridobenxoxazepines, dibenzothiazepines, dibenzodiazepines and benzonapthoxazepines. These studies were also expanded to investigate the synthesis of benzoxazepinodibenzoxazepines and benzoxazepinobenzonapthoxazepines via the double-cyclisation of the appropriate bis-isothioc

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12

INGARRA, Angela Maria. "FUSED NITROGEN HETEROCYCLES AS PROMISING SMALL MOLECULES FOR THE TREATMENT OF CANCER." Doctoral thesis, Università degli Studi di Palermo, 2020. http://hdl.handle.net/10447/395424.

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13

Fulton, Craig Kennedy. "The microbial transformation of nitrogen and sulphur containing heterocycles fused to aromatic centres." Thesis, University of Leicester, 2000. http://hdl.handle.net/2381/29649.

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The microbial degradation of isothiazolin rings was investigated. A mixed culture of bacteria able to utilise the isothiazolin ring containing compound saccharin as a source of carbon and nitrogen was isolated. A single type of bacterium able to utilise saccharin as a source of nitrogen was isolated from the community and identified as an Alcaligenes sp. A second organism able to utilise benzoate as a carbon source was isolated and identified as a Pseudomonas sp. Together the two bacteria were able to utilise saccharin as a source of carbon and nitrogen. The end products ammonia, sulphite, sul

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14

Willumstad, Thomas P. (Thomas Paul). "Synthesis of highly substituted benzo-fused nitrogen heterocycles via tandem benzannulation/cyclization strategies." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/84379.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2013.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Benzannulations employing ynamides and vinylketenes (generated in situ from [alpha]-diazo ketones) were investigated. Irradiation of the diazo ketones using a batch or continuous-flow reactor leads to the formation of vinylketenes via a photo-Wolff rearrangement. The vinylketenes then react with ynamides via a pericyclic cascade process to produce highly substituted aniline derivatives. Using this vinylketene-based benzannulation,

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15

Mak, Xiao Yin. "Tandem benzannulation-ring closing metathesis strategy for the synthesis of benzo-fused nitrogen heterocycles." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/46034.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2008.<br>Vita.<br>Includes bibliographical references.<br>A tandem benzannulation-ring closing metathesis strategy for the efficient synthesis of benzo-fused nitrogen heterocycles such as dihydroquinolines, benzazepines, and benzazocines has been developed. This strategy is based on the benzannulation reaction of ynamides with cyclobutenones or [alpha]-diazo ketones to generate highly-substituted aniline derivatives, which then participate in ring-closing metathesis reactions to form nitrogen heterocycles. The syntheti

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16

Hron, Rebecca. "Design, Synthesis and Glioblastoma Activity of 1,3-Diazinane Based Aryl Amides and Benzo Fused Heterocycles." ScholarWorks@UNO, 2017. http://scholarworks.uno.edu/td/2301.

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The development of novel targeted therapeutics for the treatment of cancer remains difficult due to the complex nature of the disease itself as well as the challenges associated with the synthesis of these therapeutics. Impediments to the discovery of novel drug candidates include lack of available starting materials and access to well-developed syntheses which are both convenient and economically feasible. Semicarbazides, for instance, are a critical synthon for the manufacture of numerous biologically important molecules. Historically, convenient methods for the synthesis of semicarbazides a

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17

Suzuki, Yamato. "Diversity-Oriented Syntheses of Fused Nitrogen Heterocycles and Their Application to the Structure-Activity Relationship Studies on CK2 Inhibitors." 京都大学 (Kyoto University), 2012. http://hdl.handle.net/2433/157893.

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18

Brown, Barber Jennifer Crystal. "Synthesis of Fused Heterocyclic Diamidines for the Treatment of Human African Trypanosomiasis and Fluorescence Studies of Selected Diamidines." Digital Archive @ GSU, 2010. http://digitalarchive.gsu.edu/chemistry_diss/38.

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A class of linear diamidines was synthesized for the evaluation as a treatment of Human African Trypanosomiasis. These fused heterocyclic compounds are thiazole[5,4-d]thiazoles and are of interest because the parent compound, 2,5-Bis(4-amidinophenyl)-thiazolo[5,4-d]thiazole HCl salt, which is also called DB 1929, has exhibited a low nanomolar IC50 value against Trypanosoma brucei rhodesiense and has shown selectivity for binding to the human telomere G-quadruplex over that of DNA duplex. A fluoro and a methoxy derivative have been synthesized and are currently undergoing testing for activity a

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19

Alawode, Olajide E. "Part 1: Mechanistic insights into the photochemistry of tetrazolethiones Part 2: Synthesis of phenanthridine-fused quinazoliniminium and computational investigation of their optoelectronic properties." Diss., Kansas State University, 2012. http://hdl.handle.net/2097/13652.

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Doctor of Philosophy<br>Department of Chemistry<br>Sundeep Rayat<br>Research in our laboratory has focused on designing photoactivated DNA cleaving agents based on tetrazolethione scaffolds. The key step in the activation of these involves conversion of tetrazolethione moiety to carbodiimides upon irradiation. However, the mechanism of this reaction was not previously reported. Therefore, we undertook a study to elucidate the mechanism of photodecomposition of tetrazolethione as to identify reactive intermediates involved, that may interfere or aid with the activity of our synthesized DNA clea

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20

Cartwright, Matthew William. "Highly functionalised fused heterocycle synthesis from fluoropyridines." Thesis, Durham University, 2006. http://etheses.dur.ac.uk/2622/.

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Current approaches to drug discovery tends to involve the rapid analogue synthesis and testing of small, focused libraries of low molecular weight, structurally similar "drug-like" molecules, often based around heterocyclic core scaffolds. If some desired activity is shown by a compound, elaboration can give higher activity and more favourable pharmiokinetic properties. As this "lead generation" stage of drug development has been identified as a major bottleneck in the drug pipeline process, there is a great demand for methodology detailing the synthesis of highly functionalised heterocyclic c

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21

Milligan, Andrew Alexander. "Novel pyrolytic routes to fused heterocyclic rings." Thesis, University of Edinburgh, 2003. http://hdl.handle.net/1842/15389.

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Substituted benzo[<i>b</i>]thiophenes were synthesised from 2-(<i>S</i>-allyl)- or 2-(<i>S</i>-benzyl)-cinnamic ester derivatives utilising flash vacuum pyrolysis (FVP). Under these conditions the benzyl or allyl groups cleaved from the precursor to form a thiophenoxyl radical which then cyclised with the ejection of the ester function as a radical leaving group. A deuteriated precursor was also synthesised to investigate the breakdown pathway during electron impact mass spectrometry. The reactions of some indole-based radicals were investigated. Thus iminyl radicals were generated from 2-thio

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22

Jackson, P. Mark. "Diels-Alder reactions of heterocyclic fused α-pyrones". Thesis, Loughborough University, 1991. https://dspace.lboro.ac.uk/2134/27733.

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The chemistry of heterocyclic analogues of orthoquinodimethane is reviewed. Benzothieno[2,3-c]pyran-3-ones and the isomeric [3,2-c]pyranones are stable analogues of benzothiophene-2,3-qyinodimethane. When heated with alkynes they undergo Diels-Alder reaction to give, after loss of carbon dioxide, dibenzothiophenes.

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23

Sengpracha, Waya. "Synthesis of biologically active indole-fused heterocyclic derivatives." Department of Chemistry - Faculty of Science, 2005. http://ro.uow.edu.au/theses/279.

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New synthetic routes to 1,2- and 2,3-fused indoles with seven- or eight-membered rings have been developed in this project, with the longer term aim of assessing their biological activity. Approaches to such fused indole derivatives were accessed via free radical cyclisation from 1- or 2-substituted indole derivatives with haloacetamide precursors. Using 1-substituted indole derivatives with haloacetamide functionalites, free radical cyclisation reactions gave fair yields of the indole- and dihydroindole-fused eight membered ring derivatives. Using 2-substituted indole derivatives with haloace

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24

Robinson, William J. III. "Development of Tetrathiafulvalene Fused N-Heterocyclic Carbene Compounds." Wright State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=wright1610382201476554.

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25

Noble, A. "Investigation into the use of 1,2-diamines in fused heterocycle synthesis." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1346443/.

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The introductory chapter of this thesis gives a brief outline of the literature concerning the importance of 1,2-diamines. This includes their biological significance, their successful application to synthetic chemistry, especially in asymmetric synthesis, and methods available for their preparation. One particular method, the nitro-Mannich reaction, is reviewed in more detail. The synthetic utility of the products of the nitro-Mannich reaction is demonstrated by their application to the synthesis of natural products and pharmaceutical agents. Improvements to the scope of the nitro-Mannich rea

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26

Sprick, Reiner Sebastian. "Polytriarylamines containing fused ring and heterocyclic structures prepared using N-heterocyclic carbene complexes of palladium." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/polytriarylamines-containing-fused-ring-and-heterocyclic-structures-prepared-using-nheterocyclic-carbene-complexes-of-palladium(c09188eb-490b-452c-945a-22979f58c76d).html.

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For the preparation of semiconducting polymers often ‘standard’ catalytic systems are used without further optimisation. New ligands, such as N-heterocyclic carbenes have shown excellent activity in cross-coupling reactions (e.g. Suzuki-Miyaura reaction, or Hartwig-Buchwald amination). These systems show excellent conversions under mild conditions and even allow the use of aryl chlorides as reagents. Nevertheless, previously no system has been reported for the synthesis of conjugated polymers, e.g. the Suzuki polycondensation or Buchwald-Hartwig type polycondensation using these catalysts. A N

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27

Geraghty, Paul Bythell. "Studies towards the synthesis of fused N-Heterocyclic carbene precursors." Thesis, University of Canterbury. Chemistry, 2013. http://hdl.handle.net/10092/8197.

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This thesis describes the preparation of a various NHC ligands with five and six-membered rings, different fused aromatic cores and the subsequent synthetic development of their complexation of with Ag, Ru and Pd. The investigation and preparation of these compunds was with the intention of exploring their chemical and physical properties. The synthesis of the NHC ligands proved to be difficult, but analysis and characterisation of the side products from the reactions helped to establish successful synthetic methodologies. In both the five and six-membered research conducted a common attribute

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28

Uzelac, Eric James. "Thiazole vs. Thiophene: Heterocycle Effects on the Properties of Fused-Ring Conjugated Materials." Diss., North Dakota State University, 2017. https://hdl.handle.net/10365/29091.

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Conjugated polymers and related molecular materials comprise a field of materials chemistry focused on the development of semiconducting organic plastics that find use in applications such as organic solar cells and organic light-emitting diodes. The optical and electronic properties of these molecules, such as absorption and emission of light, can be tuned through engineering at the molecular level. However, many of the current molecules of choice suffer from high-lying frontier orbitals, which results in a mismatch of energy levels to common components of electronic devices along with potent

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29

Leung, Qing-yun, and 梁青雲. "Synthesis, characterization and photovoltaic applications of fused heterocyclic molecules with intramolecular charge transfer properties." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44527755.

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30

Dincoflaz, Yasemin. "The Synthesis Of 6- And 7- Membered Heterocyclic Ring Systems Fused To Pyridine Ring." Master's thesis, METU, 2013. http://etd.lib.metu.edu.tr/upload/12615579/index.pdf.

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The synthesis of the nitrogen containing heterocyclic compounds is one of the leading research areas throughout the organic chemistry due to their significant activities in biological systems. Among the various biologically active molecules, pyridine-fused ring systems are of prime importance on the grounds of their proven clinical roles. The coupling reactions with 6-membered heterocyclic compounds and diazepines gave rise to new pharmalogical compounds in recent years. Therefore, our object was the synthesis of pyridine-fused 6- and 7-membered heterocycles. Starting from bromopyridine, two d

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31

BENZI, ALICE. "Synthesis and applications of fused N- and O-heterocyclic systems from nitrodienic building-blocks." Doctoral thesis, Università degli studi di Genova, 2022. http://hdl.handle.net/11567/1075546.

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N-containing and O-containing heterocycles are widely distributed in natural products essential for life and are often responsible for the pharmaceutical activity of a lot of drugs and lead-compounds. Exploiting the electrophilic nature of functionalized nitrodienic building-blocks, combined with an opportune nuclophile, new protocols for the synthesis of fused N- and O-heterocycles, has been developed. When using 2-aminopyridines or pyrrole as nucleophiles in the reaction with a suitable nitrodienic building block, it is possible to obtain imidazo[1,2-a]pyridines and 7-aryl-6-nitroindoles r

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32

Guardado, Puentes Julian. "Trans diequatorially fused 3',3'-Diphenyl-2'-morpholinone derivatives of 2-Amino-2-deoxy-D-glucose." Scholarly Commons, 1985. https://scholarlycommons.pacific.edu/uop_etds/2113.

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The chemistry of amino sugar compounds has been studied in the last years in connection with the study of natural products, and many of them have been isolated. 57,17,18 Amino sugars play an important role in biochemistry, forming blocks of homo- and heteropolymers and complex molecules such as microbial polysaccharides, enzymes, gangliosides, glycoproteins, and antibiotics. This research project had the purpose of preparing a derivative of 2-amino-2-deoxy-D-glucose, with a free hydroxyl group at the anomeric carbon, with the 4,6-positions blocked with the benzylidene cyclic acetal, and the 2,

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33

Kaplan, Hilan. "A General Approach to Cis-Fused Sesquiterpene Quinones and Synthesis, Characterization, and Catalytic Applications of Bis(Imino)-N-Heterocyclic Carbene Complexes of Iron." Thesis, Boston College, 2014. http://hdl.handle.net/2345/3862.

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Thesis advisor: James P. Morken<br>Sesquiterpene quinones are a prolific class of marine natural products that are particularly interesting due to their antibacterial, antiviral, and anti-inhibitory properties. Hundreds of these biologically active molecules are based on decalin frameworks, both cis- as well as trans-fused, however, significantly less synthetic work has focused on targeting the cis-fused series of compounds. In this chapter, progress towards an asymmetric, general route to various sesquiterpene quinones in the cleordane family of natural products will be described. The key ste

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34

He, Jiang [Verfasser], Todd B. [Gutachter] Marder, Maik [Gutachter] Finze, and Florian [Gutachter] Beuerle. "Studies of N-heterocyclic olefins as donors in triarylboranes and electron-poor phenylpyridyl-fused boroles / Jiang He ; Gutachter: Todd B. Marder, Maik Finze, Florian Beuerle." Würzburg : Universität Würzburg, 2020. http://d-nb.info/1222910543/34.

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Shah, Sana. "Synthesis and Characterization of Manganese Pyridazyl Complexes." TopSCHOLAR®, 2013. http://digitalcommons.wku.edu/theses/1298.

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Heterocyclic’s and their fused-ring derivatives have been of interest for their use in electronic materials due to their ease of production, synthetic versatility, and low cost compared to traditional inorganic materials like silicon. Pyridazines have been found to be useful in catalysis gas storage, polymeric sensors and biological mimetics. When a transition-metal is fused into a synthesized pyridazine, unique properties such as conductivity and optics are allowed. In this work, synthesized pyridazine complexes will be analyzed by mass spectroscopy, elemental analysis, nuclear magnetic reson

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36

Ziffle, Vincent Elan. "Synthesis of benzo-fused nitrogen heterocycles and substituted benzenes." 2010. http://hdl.handle.net/10048/1009.

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Thesis (Ph. D.)--University of Alberta, 2010.<br>Title from pdf file main screen (viewed on June 24, 2010). A thesis submitted to the Faculty of Graduate Studies and Research in partial fulfillment of the requirements for the degree of Doctor of Philosophy, Department of Chemistry, University of Alberta. Includes bibliographical references.

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Ziffle, Vincent. "Synthesis of benzo-fused nitrogen heterocycles and substituted benzenes." Phd thesis, 2010. http://hdl.handle.net/10048/1009.

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The first chapter of this thesis represents the continued development of a general method for the formation of benzo-fused N-heterocycles by formal radical cyclization onto benzene rings. Important stages in this process involve 1) the copper-mediated coupling of various amino alcohols to protected p-iodophenols, 2) carbamate-protection of the resulting aryl secondary amine to allow the following oxidation step, 3) the oxidative formation of quinone ketals as radical acceptors, 4) the radical cyclization of pendant iodo-radical triggers onto the cross-conjugated ketone, and 5) the subsequent

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38

Cheung, Lawrence. "Synthesis of Fused Nitrogen Containing Heterocycles via Cascade Reactions." Thesis, 2012. http://hdl.handle.net/1807/33870.

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The synthesis of fused nitrogen heterocycles has been investigated. Chapter 1 describes the synthesis of quinolones through a copper catalyzed amide coupling to ortho acetyl aryl halide followed by an aldol condensation that produces the quinolone in modest to good yields. The reaction works well with lactam partners and leads to tricyclic ring systems. Chapter 2 describes the synthesis of 8 membered enamide rings through a [3,3] sigmatropic rearrangement ring expansion of N-vinyl β-lactams. The N-vinyl β-lactams also undergo a 6π electrocyclization following the [3,3] sigmatropic rearrangemen

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Shen, Po-Jung, and 沈柏榕. "Synthesis of Nitrogen-containing [6,5]-fused heterocycles as Anticancer Agents." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/85895386237269685171.

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碩士<br>臺北醫學大學<br>藥學研究所<br>99<br>Histone deacetylase inhibitors (HDACi) have been used for anticancer drugs broadly. Some of them were approved by FDA, for example ZolinzaR and RomidepsinR for treatment of refractory cutaneous T-call lymphoma. Therefore, to target histone deacetylase provides a potential methodology to develop potent anticancer agents. To cording to the structures of HDACi, our laboratory found benzamide and N-hydroxyacrylamide important to HDAC inhibition activity. Besides, we observed some small molecular anticancer drugs containing nitrogen-containing [6,5]-fused heterocycles

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Dhole, Sandip Popat, and 杜杉帝. "Design and Synthesis of Biologically Interesting Novel Fused/Linked Heterocycles." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/62q43m.

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41

Madeley, Lee Gavin. "Synthesis of benzo-fused heterocycles using isometerization and ring-closing metathesis reactions." Thesis, 2011. http://hdl.handle.net/10539/9127.

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The first part of the dissertation involves the use of ruthenium mediated isomerization (RMI) followed by ring-closing metathesis (RCM) on a selection of phenols and naphthol-1-ol precursors – that had been subjected to allylation; followed by a heat initiated Claisen rearrangement; followed by re-allylation – to form a selection of benzofurans. This procedure, to the best of our knowledge, represents a novel method for the synthesis of benzofurans, with very good average yields of around 90% overall for the RMI/RCM and allylation steps. The lowest yield of the five synthetic steps, were for t

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42

Schulman, Jacqueline Madeleine. "Synthesis of 1,2,3-Triazole-fused Heterocycles via Palladium Catalyzed Annulation of 5-Iodotriazoles." Thesis, 2011. http://hdl.handle.net/1807/31434.

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Increasing attention has recently been directed toward 1,2,3-triazole-containing compounds. With their unique properties and excellent stability, 1,4-disubstituted triazoles are readily accessible via the copper catalyzed azide alkyne cycloaddition (CuAAC). As compounds containing fused triazoles become common in pharmaceutical targets and biologically active substances, new strategies to synthesize this class of molecules are highly desirable. An efficient and highly modular approach toward the synthesis of three different heterocyclic motifs containing fused 1,2,3-triazoles is reported.

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Chen, Jiun-Jia, and 陳俊嘉. "Synthesis of Coumarin/Phenanthridine-fused N-Heterocycles and Their Photochemical and Thermochromic Properties." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/27577941977535905616.

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碩士<br>東海大學<br>化學系<br>98<br>Four coumarin and phenanthridine-fused heterocycles 1, 2, 12, and 27 were efficiently synthesized using base-catalyzed annulation of 4-methylquinolinium iodide and coumarin as a key step. Compound 1 is sensitive to light and changes color upon UV irradiation, compounds 12 and 27 are sensitive to heat and possesses thermochromic properties, and compound 2 is sensitive to both light and heat. A novel heat and light-sensitive molecular skeleton is introduced.

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Bailey, Timothy Samuel. "Synthesis of fused medium-ring heterocycles by the rearrangement of quaternary ammonium derivatives." Thesis, 1994. https://eprints.utas.edu.au/18986/1/whole_BaileyTimothySamuel1994_thesis.pdf.

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The general aim of this study was to develop new modes of access to benzfused medium-ring heterocycles. The approach adopted was to utilise the rearrangements, with concurrent ring expansion, of heterocyclic quaternary ammonium N-ylides and N-oxides. Of particular interest were new applications of the [2,3] rearrangements of these systems. Base promoted [2,3] sigmatropic rearrangement of 1-viny1-2- ethoxycarbonylmethyl-1,2,3,4-tetrahydroisoquinolinium salts at room temperature in acetonitrile afforded functionalised 2,3,4,5-tetrahydro-1H-3-benzazonine derivatives, as mixtures of the o

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Alberico, Dino. "Norbornene-mediated palladium-catalyzed synthesis of fused aromatic carbocycles and heterocycles /by Dino Alberico." 2006. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=442417&T=F.

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Lin, Pin-Hui, and 林品慧. "Visible-Light-Mediated Reactions: Synthesis of Coumarin/Imidazopyridine-Fused Heterocycles from 4-Heteroarylamino-3-nitrocoumarins." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/fm66fb.

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碩士<br>東海大學<br>化學系<br>105<br>This thesis mainly described the application of visible light to promote the cyclization of 3-nitro-4-(quinazolin-4-ylmethyl)coumarin to give an alkaloid lamellarin core-like compound in the absence of photosensitizer. A series of 2-aminopyridine- and coumarin-fused derivatives were synthesized via visible light-mediated cyclization of 3-nitro-4-(quinazolin-4-ylmethyl)coumarins and their molecular structures were characterized by 1H and 13C spectra and X-ray crystal analysis. A possible mechanism for this visible light-mediated cyclization was proposed on the basis

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Kevin, Chang, and 鄭奎文. "Preparation and Physical Characterization of Tetraalkylammonium Salts of p-Benzoquinoe Derivatives Fused with Sulphur- Containing Heterocycles." Thesis, 1993. http://ndltd.ncl.edu.tw/handle/32604011243847582017.

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碩士<br>淡江大學<br>化學學系<br>81<br>Simple and complex alkylammonium salts of electron acceptors Qmnt (5,10-dihydro-5,10-dioxo-[1,2,-b:4,5-b ]bis[1,4]dithiole- benzo-2, 3,7,8-tetracarbonnitrile) and Qimnt(2,2 -(4,8-dihydro-4,8-dioxo -[1,2-d:4,5-d ]-bis[1,3 ]dithioilebenzo-2,6-diylidene)-bispropandi nitrile) were prepared by reactions of the acceptors with R4NI in acetonitrile. These salts were studied using various techniques, including infrared and electronic absorption spectracopie

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Huang, Richard Yichong. "Domino C-H Functionalization Reactions of gem-Dibromoolefins: Synthesis of N-Fused Benzo[c]carbazoles." Thesis, 2012. http://hdl.handle.net/1807/33248.

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The development of a novel palladium-catalyzed domino reaction with indole-based gem-dibromoolefin substrates is described. The reaction allowed access to a new class of polycyclic nitrogen heterocycles: N-fused benzo[c]carbazoles. A key feature of this domino reaction was the participation of both bromides in C–H functionalization processes, a hitherto unprecedented reactivity. Various substituents and substitution patterns were tolerated in this reaction, allowing for a highly modular approach to these challenging synthetic targets. Mechanistic studies were performed to gain further insight

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Cho-Chin, Young, and 楊朝欽. "Physical Characterization and structure of Tetraalkylammonium Salts of p-Benzoquinoe Fused with Sulphur-Containing Heterocycles by electrocrystallized." Thesis, 1994. http://ndltd.ncl.edu.tw/handle/32849054606809041429.

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碩士<br>淡江大學<br>化學學系<br>82<br>Simple and complex alkylammonium salts of electron acceptors Qimnt(2,2''-(4,8-dihydro-4,8-dioxo-[1,2-d:4,5-d''] -bis[1,3] dithiolebenzo-2,6-diylidene)-bispropanedinitrile were electrocrystallized by reaction of the electron acce- ptor with R4NBr ( R= tetramethylammonium,tetraethylammonium ,tetrapropylammonium, tetrabutylammonium ) in acetonitrile. Physical properties of these crystals were also measured, including infrared spectra , ultraviolet-visible spectra ,

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Lee, Chang Suk. "Synthesis of Haptens for the Marine Toxin, Gymnodimine; Synthesis of Beta-lactone Fused Carbocycles and Nitrogen Heterocycles; Efforts Toward the Synthesis of the Proposed Structure of Thiolyngbyan." Thesis, 2010. http://hdl.handle.net/1969.1/ETD-TAMU-2010-05-7768.

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Contamination of seafood by marine toxins has been a consistent public health problem. Gymnodimine (GYM) is a member of a family of spirocyclic imine containing marine natural products which was shown to be highly toxic (LD50 96 mg/kg, intraperitoneal injection); thus ensuring public safety requires stringent monitoring of gymnodimine. Current detection methods for GYM and spirolides include the mouse bioassay and LC-MS-based detection techniques which, however, have significant limitations. Therefore, more efficient and convenient detection methods are required. Building on our recently compl

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