Relevant bibliographies by topics / His95

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'His95'

Author: Grafiati
Published: 14 March 2023
Last updated: 31 July 2025

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Journal articles on the topic "His95"

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Rehl, Kristen M., Jayaraman Selvakumar, Rhonda L. Pitsch, et al. "A new ferrocene derivative blocks K-Ras localization and function by oxidative modification at His95." Life Science Alliance 6, no. 11 (2023): e202302094. http://dx.doi.org/10.26508/lsa.202302094.

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Ras proteins are membrane-bound GTPases that regulate essential cellular processes at the plasma membrane (PM). Constitutively active mutations of K-Ras, one of the three Ras isoforms in mammalian cells, are frequently found in human cancers. Ferrocene derivatives, which elevate cellular reactive oxygen species (ROS), have shown to block the growth of non-small cell lung cancers harboring oncogenic mutant K-Ras. Here, we tested a novel ferrocene derivative on the growth of pancreatic ductal adenocarcinoma and non-small cell lung cancer. Our compound, which elevated cellular ROS levels, inhibit
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Gao, Miaomiao, Kaili Nie, Meng Qin, Haijun Xu, Fang Wang та Luo Liu. "Molecular Mechanism Study on Stereo-Selectivity of α or β Hydroxysteroid Dehydrogenases". Crystals 11, № 3 (2021): 224. http://dx.doi.org/10.3390/cryst11030224.

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Hydroxysteroid dehydrogenases (HSDHs) are from two superfamilies of short-chain dehydrogenase (SDR) and aldo–keto reductase (AKR). The HSDHs were summarized and classified according to their structural and functional differences. A typical pair of enzymes, 7α–hydroxysteroid dehydrogenase (7α–HSDH) and 7β–hydroxysteroid dehydrogenase (7β–HSDH), have been reported before. Molecular docking of 7-keto–lithocholic acid(7–KLA) to the binary of 7β–HSDH and nicotinamide adenine dinucleotide phosphate (NADP+) was realized via YASARA, and a possible binding model of 7β–HSDH and 7–KLA was obtained. The α
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Viles, John H., Mark Klewpatinond, and Rebecca C. Nadal. "Copper and the structural biology of the prion protein." Biochemical Society Transactions 36, no. 6 (2008): 1288–92. http://dx.doi.org/10.1042/bst0361288.

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PrP (prion-related protein) is a cell-surface Cu2+-binding glycoprotein which, when misfolded, is responsible for a number of transmissible spongiform encephalopathies. The co-ordination geometry, stoichiometry and affinity of Cu2+ for PrP are the subject of much debate. In the present paper, we review the recent progress we have made in these areas. As many as six Cu2+ ions bind to PrP with submicromolar affinity. Initially, two Cu2+ ions bind to full-length PrP in the amyloidogenic region, between the octarepeats and the structured domain, at His95 and His110. Only subsequent Cu2+ ions bind
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Yang, Hailong, Lu Gan, and Huabei Zhang. "Design, Synthesis, Anticancer Evaluation and Molecular Docking of Pyrimidine, Pyrido[4,3-d]pyrimidine and 5,6,7,8-Tetrahydropyrido[3,4-d]pyrimidine Derivatives as Novel KRAS-G12D Inhibitors and PROTACs." Pharmaceuticals 18, no. 5 (2025): 696. https://doi.org/10.3390/ph18050696.

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Background: KRAS-G12D mutations drive 20–50% of pancreatic/biliary cancers yet remain challenging to target due to GTP-pocket conservation and high cellular GTP levels. While allosteric inhibitors targeting the SWII pocket (e.g., MRTX1133) show promise, limited chemical diversity and paradoxical cellular/enzymatic activity relationships necessitate the exploration of novel scaffolds. This study aims to develop KRAS-G12D inhibitors and PROTACs to offer a selection of new chemical entities through systematic structure–activity optimization and evaluate their therapeutic potential through PROTAC
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Bsat, Nada, and John D. Helmann. "Interaction of Bacillus subtilis Fur (Ferric Uptake Repressor) with the dhb Operator In Vitro and In Vivo." Journal of Bacteriology 181, no. 14 (1999): 4299–307. http://dx.doi.org/10.1128/jb.181.14.4299-4307.1999.

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ABSTRACT Bacillus subtilis contains three metalloregulatory proteins belonging to the ferric uptake repressor (Fur) family: Fur, Zur, and PerR. We have overproduced and purified Fur protein and analyzed its interaction with the operator region controlling the expression of the dihydroxybenzoate siderophore biosynthesis (dhb) operon. The purified protein binds with high affinity and selectivity to the dhb regulatory region. DNA binding does not require added iron, nor is binding reduced by dialysis of Fur against EDTA or treatment with Chelex. Fur selectively inhibits transcription from the dhb
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Wang, Xixi, Jiankai Shan, Wei Liu, et al. "Theoretical Studies on the Binding Mode and Reaction Mechanism of TLP Hydrolase kpHIUH." Molecules 26, no. 13 (2021): 3884. http://dx.doi.org/10.3390/molecules26133884.

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In this work, we have investigated the binding conformations of the substrate in the active site of 5-HIU hydrolase kpHIUH and its catalytic hydrolysis mechanism. Docking calculations revealed that the substrate adopts a conformation in the active site with its molecular plane laying parallel to the binding interface of the protein dimer of kpHIUH, in which His7 and His92 are located adjacent to the hydrolysis site C6 and have hydrogen bond interactions with the lytic water. Based on this binding conformation, density functional theory calculations indicated that the optimal catalytic mechanis
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Sanyanga, Taremekedzwa Allan, Bilal Nizami та Özlem Tastan Bishop. "Mechanism of Action of Non-Synonymous Single Nucleotide Variations Associated with α-Carbonic Anhydrase II Deficiency". Molecules 24, № 21 (2019): 3987. http://dx.doi.org/10.3390/molecules24213987.

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Human carbonic anhydrase II (CA-II) is a Zinc (Zn 2 + ) metalloenzyme responsible for maintenance of acid-base balance within the body through the reversible hydration of CO 2 to produce protons (H + ) and bicarbonate (BCT). Due to its importance, alterations to the amino acid sequence of the protein as a result of single nucleotide variations (nsSNVs) have detrimental effects on homeostasis. Six pathogenic CA-II nsSNVs, K18E, K18Q, H107Y, P236H, P236R and N252D were identified, and variant protein models calculated using homology modeling. The effect of each nsSNV was analyzed using motif ana
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Hempelmann, Franziska, Soraya Hölper, Mirka-Kristin Verhoefen, et al. "His75−Asp97 Cluster in Green Proteorhodopsin." Journal of the American Chemical Society 133, no. 12 (2011): 4645–54. http://dx.doi.org/10.1021/ja111116a.

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Tanley, Simon W. M., Antoine M. M. Schreurs, Loes M. J. Kroon-Batenburg, and John R. Helliwell. "Room-temperature X-ray diffraction studies of cisplatin and carboplatin binding to His15 of HEWL after prolonged chemical exposure." Acta Crystallographica Section F Structural Biology and Crystallization Communications 68, no. 11 (2012): 1300–1306. http://dx.doi.org/10.1107/s1744309112042005.

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The anticancer complexes cisplatin and carboplatin are known to bind to both the Nδand the N∊atoms of His15 of hen egg-white lysozyme (HEWL) in the presence of dimethyl sulfoxide (DMSO). However, neither binds in aqueous media after 4 d of crystallization and crystal growth, suggesting that DMSO facilitates cisplatin/carboplatin binding to the N atoms of His15 by an unknown mechanism. Crystals of HEWL cocrystallized with cisplatin in both aqueous and DMSO media, of HEWL cocrystallized with carboplatin in DMSO medium and of HEWL cocrystallized with cisplatin andN-acetylglucosamine (NAG) in DMSO
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10

Plowman, Jeffrey E., та Lawrence K. Creamer. "Restrained molecular dynamics study of the interaction between bovine κ-casein peptide 98–111 and bovine chymosin and porcine pepsin". Journal of Dairy Research 62, № 3 (1995): 451–67. http://dx.doi.org/10.1017/s0022029900031150.

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SummaryThe cleavage of bovine κ-casein at the Phe105–Met106* bond by chymosin or pepsin is the first stage in casein micelle coagulation and casein digestion. The nature of the interaction of the peptide His98–Pro–His–Pro–His–Leu–Ser–Phe105–Met–Ala–Ile–Pro-Pro-Lys111 with chymosin and porcine pepsin was investigated using molecular modelling and energy minimization techniques. This study verified and extended a proposed model that electrostatic binding (involving His98, His100, His102 and Lys111 or Lys112) at either end of the active site cleft of chymosin is important for the positioning of r
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Dissertations / Theses on the topic "His95"

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Mai, Phuong Thao. "The potential role of copper binding sites in prion propagation." Doctoral thesis, SISSA, 2014. http://hdl.handle.net/20.500.11767/3905.

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Transmissible spongiform encephalopathies (TSEs) or prion diseases are caused by a post-translational conversion of the normal cellular form of the prion protein (PrPC) into the pathological and infectious isoform denoted as prion or PrPSc. PrPC has been shown as a high-affinity copper-binding protein, and to a lesser extent binding to other divalent cations through the octarepeat region (OR) and the non-OR copper binding sites located in the disordered N-terminal domain. Studies on the role of copper in promoting prion conversion and infectivity yielded controversial results. In this work, we
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Wu, Yu-Hsun, and 吳育勳. "Mutational Analysis of Leu29 and His93 from Sperm Whale Myoglobin on the Effect of Peroxidase Activity." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/23531793287270212345.

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碩士<br>國立交通大學<br>生物資訊研究所<br>97<br>Myoglobin (Mb) is a heme-protein, functioning as oxygen carrier in vertebrates. In previous study, MbH64D/V68L/I107M had been engineered into an enzyme with peroxidase activity. We further investigated the L29X/H64D/V68L/I107M and site-saturated H93X mutational effects on peroxidase activity. A well established peroxidase activity with one-electron oxidation reacted with 2’-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) was observed by the UV/Vis spectrophotometer and demonstrated its capability in electron transfer reaction. When ABTS was used as sub
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Books on the topic "His95"

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Choe, Hui-Woog. Kristallisationsstudien an verschiedenen Proteinen: Ribulose-1,5-Bisphosphat Carboxylase Oxygenase aus Alcaligenes eutrophus H16, Ribonuclease T1 aus Aspergillus oryzae und aus einer rekombinanten Mutante (His92-Ala) und ein DNA-bindendes Escherichia coli Protein, FIS. 1989.

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Book chapters on the topic "His95"

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Achoch, Mounia, Giovanni Feverati, Kave Salamatian, Laurent vuillon, and Claire Lesieur. "Cross-Talk Between Intramolecular and Intermolecular Amino Acid Networks Orchestrates the Assembly of the Cholera Toxin B Pentamer via the Residue His94." In International Conference on Advanced Intelligent Systems for Sustainable Development. Springer Nature Switzerland, 2023. http://dx.doi.org/10.1007/978-3-031-35248-5_35.

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Bottinelli, Fiorentina, Patricia Saenz-Méndez, and Oscar N. Ventura. "Computational Study of the Initial Step in the Mechanism of Dehaloperoxidase A: Determination of the Protonation Scheme at the Active Site and the Movement of the His55 Residue." In Challenges and Advances in Computational Chemistry and Physics. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-21626-3_14.

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Helliwell, John, Antoine Schreurs, Loes Kroon-Batenburg, and Simon Tanley. "Cisplatin coordination chemistry determination at hen egg white lysozyme His15 with ligand distances and angles, and their standard uncertainties, and also reporting a split occupancy effect." In Data Review. The University of Manchester, 2016. http://dx.doi.org/10.3927/45371856.

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Conference papers on the topic "His95"

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Saiki, Anne Y., Deanna Mohn, Yu Li, et al. "Abstract 1285:In vitrocharacterization of sotorasib and other RAS ‘His95-groove' binders and investigation of resistance mechanisms." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-1285.

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Reports on the topic "His95"

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Droby, Samir, Joseph W. Eckert, Shulamit Manulis, and Rajesh K. Mehra. Ecology, Population Dynamics and Genetic Diversity of Epiphytic Yeast Antagonists of Postharvest Diseases of Fruits. United States Department of Agriculture, 1994. http://dx.doi.org/10.32747/1994.7568777.bard.

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One of the emerging technologies is the use of microbial agents for the control of postharvest diseases of fruits and vegetables. A number of antagonistic microorganisms have been discovered which have the potential to effectively control postharvest diseases. Some of this technology has been patented and commercial products such as AspireTM (Ecogen Corporatin, Langhorne, PA, USA), Biosave 10TM and Biosave 11TM (Ecoscience Inc., Worchester, MA, USA) have been registered for commercial use. The principal investigator of this project was involved in developing the yeast-based biofungicide-Aspire
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