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Dissertations / Theses on the topic 'Hit expansion'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Nordqvist, Anneli. "Hit Identification and Hit Expansion in Antituberculosis Drug Discovery : Design and Synthesis of Glutamine Synthetase and 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase Inhibitors." Doctoral thesis, Uppsala universitet, Avdelningen för organisk farmaceutisk kemi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-155428.

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Since the discovery of Mycobacterium tuberculosis (Mtb) as the bacterial agent causing tuberculosis, the permanent eradication of this disease has proven challenging. Although a number of drugs exist for the treatment of tuberculosis, 1.7 million people still die every year from this infection. The current treatment regimen involves lengthy combination therapy with four different drugs in an effort to combat the development of resistance. However, multidrug-resistant and extensively drug-resistant strains are emerging in all parts of the world. Therefore, new drugs effective in the treatment o

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Trasler, Simon Andrew. "Hig orders of Weyl expansions." Thesis, Brunel University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241650.

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Morgan, LeeAnn Jolley. "The William Primrose transcriptions : Primrose's rise to eminence and the expansion of the viola repertoire through his transcriptions /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/11231.

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Pinheiro, Karisa Lorena Carmo Barbosa. "O processo de urbaniza??o de Mossor?: dos processos hist?ricos ? estrutura urbana atual." Universidade Federal do Rio Grande do Norte, 2006. http://repositorio.ufrn.br:8080/jspui/handle/123456789/12418.

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Made available in DSpace on 2014-12-17T13:57:19Z (GMT). No. of bitstreams: 1 KarisaLCBP_ate_cap4.pdf: 2608849 bytes, checksum: cbca79cb026279c0a67fcb2da3b8a521 (MD5) Previous issue date: 2006-12-11<br>The general objective of this academic work is to analyze the relationship between the territorial division and the urban expansion process of Mossor? city, understood here as the production and occupation of space. The urban expansion in Mossor?, since its formation as settlement in 1772 until current days, identifies with the Brazilian urbanization process whose growth is determined by the

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De, Kock Michiel Burger. "Gaussian and non-Gaussian-based Gram-Charlier and Edgeworth expansions for correlations of identical particles in HBT interferometry." Thesis, Stellenbosch : University of Stellenbosch, 2009. http://hdl.handle.net/10019.1/3124.

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Thesis (MSc (Physics))--University of Stellenbosch, 2009.<br>Hanbury Brown-Twiss interferometry is a correlation technique by which the size and shape of the emission function of identical particles created during collisions of high-energy leptons, hadrons or nuclei can be determined. Accurate experimental datasets of three-dimensional correlation functions in momentum space now exist; these are sometimes almost Gaussian in form, but may also show strong deviations from Gaussian shapes. We investigate the suitability of expressing these correlation functions in terms of statistical quanti

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Wang, Ling, Juan Zhao, Junping P. Ren, et al. "Expansion of Myeloid-Derived Suppressor Cells Promotes Differentiation of Regulatory T Cells in HIV-1+ Individuals." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/6532.

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Objective: Regulatory T cells (Tregs) contribute to HIV-1 disease progression by impairing antiviral immunity; however, the precise mechanisms responsible for the development of Tregs in the setting of HIV-1 infection are incompletely understood. Design: In this study, we provide evidence that HIV-induced expansion of monocytic myeloid-derived suppressor cells (M-MDSCs) promote the differentiation of Foxp3+ Tregs. Methods: We measured MDSC induction and cytokine expression by flow cytometry and analyzed their functions by coculturing experiments. Results: We observed a dramatic increase in M-M

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Gama, Lucio. "Mudanças em subgrupos de monócitos durante infecção aguda pelo vírus da imunodeficiência símia (SIV); expansão de uma população inédita de células CD14+CD16- com um fenótipo atípico CCR2-." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5146/tde-22092011-115312/.

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Monócitos podem ser classificados em três subgrupos de acordo com o nível de expressão dos marcadores CD14 e CD16. Monócitos clássicos são os mais abundantes no sangue. Eles expressam um fenótipo CD14+CD16-CCR2+, conferindo a eles a habilidade de migrar rapidamente a sítios inflamatórios, através da resposta à quimiocina CCL2 (CC chemokine ligand 2). Aqui apresentamos a identificação e caracterização de uma expansão de um novo subgrupo de monócitos durante a infecção por SIV e HIV. Essas células são indistinguíveis dos monócitos clássicos quanto à expressão de CD14 e CD16; porém não expressam

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8

Almutairi, Hamad Hhn. "Low energy air conditioning for hot climates." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/low-energy-air-conditioning-for-hot-climates(8e4fe7e9-c0d0-4bc3-8b81-96ced66331e1).html.

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Fossil fuels are the major sources of electrical power generation in the world. Among all fossil fuels, oil is considered as the most sought-after fuel. The burden on countries that provide subsidized electricity produced from oil-fired power plants is noteworthy. Kuwait is a notable example of these countries. Electricity in Kuwait is heavily consumed by residential air conditioning, which comprises 60% of the total electricity generated at peak times on a hot summer day. From this perspective, residential air conditioning in Kuwait was selected to undergo further investigation regarding low

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López, González Alejandro. "In silico strategies for the design of RNA binders: focus on nucleotide repeat expansion disorders and HIV-1." Doctoral thesis, Universitat Ramon Llull, 2016. http://hdl.handle.net/10803/369297.

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Tradicionalment, el disseny de fàrmacs s’ha basat en utilitzar molècules per tractar dianes biològiques clau o en una via metabòlica concreta, típicament proteïnes. No obstant, aquest paradigma està evolucionant de forma que el problema a resoldre no es troba només en entendre l’activació o inactivació de proteïnes sinó en controlar la maquinària interna que utilitza la cèl·lula per produir aquestes proteïnes. De la mateixa manera, les malalties conegudes com a minoritàries tenen els seus orígens en la genètica, i la utilització de proteïnes com a diana terapèutica ha esdevingut insuficient.

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Carvalho, Elmo Jos? Carneiro. "A expans?o urbana da cidade de Serrinha - Bahia e suas repercuss?es sobre os recursos h?dricos." Universidade Estadual de Feira de Santana, 2017. http://localhost:8080/tede/handle/tede/622.

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Submitted by Jadson Francisco de Jesus SILVA (jadson@uefs.br) on 2018-03-02T21:49:53Z No. of bitstreams: 1 Elmo Jos? Carneiro Carvalho - Disserta??o.pdf: 11843086 bytes, checksum: c09d8b9867b5deb817f3f17ab0119c80 (MD5)<br>Made available in DSpace on 2018-03-02T21:49:53Z (GMT). No. of bitstreams: 1 Elmo Jos? Carneiro Carvalho - Disserta??o.pdf: 11843086 bytes, checksum: c09d8b9867b5deb817f3f17ab0119c80 (MD5) Previous issue date: 2017-08-30<br>This paper aims to analyze the urban sprawl of Serrinha and its impact on local water resources. From information acquired based on local history and an

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Villegas, Prados David. "Analysis of Hall effect thrusters using Hybrid PIC simulations and coupling to EP plume." Thesis, Luleå tekniska universitet, Rymdteknik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-80641.

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In the last 30 years, numerical models have been developed to properly analyze Hall eect thrusters (HET),leading to a bridge between analytical prediction/empirical intuition and experiments. For companies in thespace sector, these codes serve to much more than simply simulating the thruster, but it provides a fast, cheapand reliable tool for processes such as validation and verication procedures, as well as for technical developmentof the thruster. During the testing of the thruster, mostly measurements upstream from the thruster exhaustare obtained since the high density plasma inside the ch

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12

Hamaji, Adilson. "Estudo prospectivo randomizado comparando duas técnicas de expansão volêmica em cirurgia de artroplastia total de quadril: hidroxietilamido (130/0,4) e Ringer lactato." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/5/5152/tde-27082009-154106/.

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Introdução: Os hidroxietilamidos (HES) são considerados expansores plasmáticos efetivos em pacientes submetidos a procedimentos cirúrgicos de grande porte. Entretanto, seu uso clínico é limitado principalmente por sua interferência na hemostasia, representada por alterações da função plaquetária e na coagulação. A extensão dessas alterações está relacionada ao seu ipeso molecular ou à sua substituição molar. Este estudo clínico, foi realizado durante cirurgia de artroplastia de quadril em pacientes adultos para comparar os efeitos do HES (130/0,4) e a solução de Ringer lactato em relação ao sa

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13

Ngom, Ndeye Fatou. "Enjeux de la prise en charge thérapeutique du VIH au Sénegal." Thesis, Montpellier, 2018. http://www.theses.fr/2018MONTT098/document.

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RESUME : La communauté internationale s’est engagée à mettre fin à l’épidémie de sida d’ici à 2030. L’atteinte de cet objectif repose sur la capacité des programmes de lutte contre le VIH à apporter le traitement à toutes les personnes vivant avec le VIH et à maintenir ces personnes sous traitement avec une charge virale contrôlée le plus longtemps possible. Des progrès considérables ont été réalisés ces dernières années en matière d’accès au traitement, mais la performance des programmes reste insuffisante en Afrique, en particulier en Afrique occidentale.Afin de mieux comprendre les obstacle

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14

Ralaidovy, Ambinintsoa Haritiana. "Efficiency in health ressource allocation : three empirical studies in Eastern Sub-Sahara Africa and Southeast Asia." Thesis, Université Clermont Auvergne‎ (2017-2020), 2019. http://www.theses.fr/2019CLFAD016.

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La définition des priorités en matière de santé, dans le contexte de la couverture sanitaire universelle, met l'accent sur trois valeurs : améliorer la santé de la population, garantir l'égalité d'accès aux services et la qualité de ceux-ci et éviter l'appauvrissement des usagers ou la sous-utilisation des services par ceux-ci en raison de dépenses non remboursables. L’efficience allocative peut être mesurée par rapport à l'une quelconque de ces valeurs, ou par rapport à l'ensemble, par différentes variantes de l'analyse coût-efficacité. Dans cette thèse, nous utilisons la « Generalized Cost-E

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15

Smith, Elaine. "An exploration of emerging problems for infant feeding options : some obstacles for the rapid expansion of the HIV mother-to-child transmission prevention programme : the KwaZulu-Natal experience." Thesis, 2003. http://hdl.handle.net/10413/4363.

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16

Odoi, Keturah. "Orthogonality and Codon Preference of the Pyrrolysyl-tRNA Synthetase-tRNAPyl pair in Escherichia coli for the Genetic Code Expansion." Thesis, 2012. http://hdl.handle.net/1969.1/ETD-TAMU-2012-05-11037.

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Systematic studies of basal nonsense suppression, orthogonality of tRNAPyl variants, and cross recognition between codons and tRNA anticodons are reported. E. coli displays detectable basal amber and opal suppression but shows a negligible ochre suppression. Although detectable, basal amber suppression is fully inhibited when a pyrrolysyl-tRNA synthetase (PylRS)-tRNAPyl_CUA pair is genetically encoded. trnaPyl_CUA is aminoacylated by an E. coli aminoacyl-tRNA synthetase at a low level, however, this misaminoacylation is fully inhibited when both PylRS and its substrate are present. Besides th

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