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Journal articles on the topic 'Hit expansion'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Stumpfe, Dagmar, Maxim Frizler, Mihiret T Sisay, et al. "Hit Expansion through Computational Selectivity Searching." ChemMedChem 4, no. 1 (2009): 52–54. http://dx.doi.org/10.1002/cmdc.200800304.

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2

Barinaga, Marcia. "Stanford animal-research facility expansion hit by local protests." Nature 329, no. 6139 (1987): 477. http://dx.doi.org/10.1038/329477a0.

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3

Parkes, Joanne. "Funded childcare expansion plans in doubt amid nursery closures." Children and Young People Now 2023, no. 8 (2023): 8–9. http://dx.doi.org/10.12968/cypn.2023.8.8.

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Councils are increasingly worried about a shortage of early education places, particularly in disadvantaged areas, and echo warnings from sector leaders that it could hit government plans for funded childcare

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Boerkamp, Martijn. "Bose–Einstein condensates hit record low temperature." Physics World 34, no. 11 (2021): 6i. http://dx.doi.org/10.1088/2058-7058/34/11/07.

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Miller, Duncan C., Mathew P. Martin, Santosh Adhikari, et al. "Identification of a novel ligand for the ATAD2 bromodomain with selectivity over BRD4 through a fragment growing approach." Organic & Biomolecular Chemistry 16, no. 11 (2018): 1843–50. http://dx.doi.org/10.1039/c8ob00099a.

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Fritsch, Katharina. "“It can hit anybody”." Kriminologisches Journal, no. 1 (March 25, 2025): 12–30. https://doi.org/10.3262/kj2501012.

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In recent years, French politics have been shaped by states of emergency, more specifically an anti-terrorist and sanitary state of emergency. At the same time, France’s public sphere has been marked by large protest movements, which have often faced state repression. Based on problem-centred interviews with protest actors belonging to environmental movements, antiracist movements and social justice movements (yellow vests, anti-gentrification) in France, with a focus on Marseille, I discuss how social movement actors frame repression, and in particular how they problematise repression. Their

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Glaser, Jens, Ada Sedova, Stephanie Galanie, et al. "Hit Expansion of a Noncovalent SARS-CoV-2 Main Protease Inhibitor." ACS Pharmacology & Translational Science 5, no. 4 (2022): 255–65. http://dx.doi.org/10.1021/acsptsci.2c00026.

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Bergner, Andreas, and Serge P. Parel. "Hit Expansion Approaches Using Multiple Similarity Methods and Virtualized Query Structures." Journal of Chemical Information and Modeling 53, no. 5 (2013): 1057–66. http://dx.doi.org/10.1021/ci400059p.

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Gelb, Betsy D., Bruce “Chip” Morris, and Ana Friedman. "Will that brand extension hit legal headwinds? The natural expansion of a trademark." Business Horizons 64, no. 5 (2021): 575–85. http://dx.doi.org/10.1016/j.bushor.2021.02.029.

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Baeyens, Nicolas, Bruno Larrivée, Roxana Ola, et al. "Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia." Journal of Cell Biology 214, no. 7 (2016): 807–16. http://dx.doi.org/10.1083/jcb.201603106.

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Morphogenesis of the vascular system is strongly modulated by mechanical forces from blood flow. Hereditary hemorrhagic telangiectasia (HHT) is an inherited autosomal-dominant disease in which arteriovenous malformations and telangiectasias accumulate with age. Most cases are linked to heterozygous mutations in Alk1 or Endoglin, receptors for bone morphogenetic proteins (BMPs) 9 and 10. Evidence suggests that a second hit results in clonal expansion of endothelial cells to form lesions with poor mural cell coverage that spontaneously rupture and bleed. We now report that fluid shear stress pot

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Mehta, Vikas. "Public Space and COVID-19: Contraction, Expansion, and Adaptation." Journal of Public Space, Vol. 5 n. 3 (November 30, 2020): 15–22. http://dx.doi.org/10.32891/jps.v5i3.1360.

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COVID-19 has hit cities hard. With the closure of places of work and learning, third places, places of leisure and consumption, and more, the pandemic has diminished our territories and contracted public space and public life. But a keen observation reveals a more nuanced picture. In many neighborhoods, an interesting phenomenon of reclaiming much neighborhood space for public use is evident. The repurposing of residential streets, sidewalks, parking lots, and other modest public spaces in neighborhoods shows an expansion of public space and sociability. This expansion is also that of agency.

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Liu, Chang, Luyang Zhang, and Xingbei Zhu. "Acquisition of Tiffany by LVMH: Successful Market Expansion Strategy." BCP Business & Management 37 (February 1, 2023): 493–501. http://dx.doi.org/10.54691/bcpbm.v37i.3601.

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As a world-renowned luxury brand, LVMH announced a deal to acquire Tiffany & Co. on November 25, 2019. However, the luxury retail industry has been hit hard by the outbreak of the epidemic, and whether the acquisition deal can be successfully completed has become a concern. What is happening behind the deal and what are LVMH's plans after the acquisition of Tiffany & Co. This article provides a comprehensive analysis of the acquisition and future marketing plans, with a special focus on LVMH's divisional financial results, operating profit and sales figures. It also compares the geogra

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Nakauchi, Yusuke, Daniel Thomas, Rajiv Sharma, et al. "Azacitidine and Ascorbate Inhibit the Competitive Outgrowth of Human TET2 Mutant HSPCs in a Xenograft Model of Pre-Leukemia." Blood 132, Supplement 1 (2018): 887. http://dx.doi.org/10.1182/blood-2018-99-113907.

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Abstract The TET2 gene is frequently mutated in pre-leukemic hematopoietic stem cells in human acute myeloid leukemia (AML) and encodes for an enzyme that catalyzes the conversion of DNA 5-methylcytosine to 5-hydroxymethylcytosine. Recent studies suggest that (i) the product of this reaction can be enhanced using high dose ascorbate, and (ii) formation of the substrate 5-methylcytosine can be blocked with azacitidine. To understand the mechanisms of TET2 mutation-driven leukemogenesis, we developed two CRISPR/Cas9 approaches to disrupt the TET2 gene in primary human CD34+ HSPCs to mimic TET2-m

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Chowdhury, Onima, Kristian Gurashi, Amy Wood, et al. "Single-Cell Multiomic Profiling of TP53 Mutated Myelodysplastic Neoplasms - All Clones Are Not Equal." Blood 144, Supplement 1 (2024): 3615. https://doi.org/10.1182/blood-2024-210047.

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Background In patients with myelodysplastic neoplasms (MDS) the acquisition of multi-hit rather than single hit TP53 mutations and chromosomal copy number alterations (CNAs) confers a dismal prognosis with no standard of care therapeutics. Currently available clinical diagnostic tests cannot confidently determine if TP53 mutations are single or multi-hit events or whether CNAs are part of the same clone. Aims We set out to apply a multiomic platform incorporating single-cell DNA sequencing and surface protein mapping to uncover the clonal architecture and clinically relevant genetic heterogene

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Deych, T. L., and V. A. Usov. "BRICS Expansion: Views of China and India." Asia & Africa today, no. 9 (December 15, 2024): 30–38. http://dx.doi.org/10.31857/s0321507524090045.

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The BRIC association created in 2009, turned into BRICS in 2011, including South Africa. South African accession to the group significantly increased its hit towards the Great South, in particular increased its interest in Africa. In August 2023, the XV BRICS Summit was held in Johannesburg, South Africa. The main topics were the expansion of the bloc, the growth of China’s influence and the decision to hold a new summit in Kazan (Russia) in 2024. The BRICS Summit in Johannesburg in August 2023 approved entering the block 5 countries, including two ones from Africa: Egypt and Ethiopia. The BRI

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Ziari, Mohammad, Catherine Burke, Karen Matevosyan, Eugene P. Frenkel, Ravindra Sarode, and Yu-Min Shen. "Optical Density of 1.0 Is a Better Cutoff for Positive HIT Ab ELISA." Blood 114, no. 22 (2009): 3515. http://dx.doi.org/10.1182/blood.v114.22.3515.3515.

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Abstract Abstract 3515 Poster Board III-452 Background Heparin-induced thrombocytopenia (HIT) is a clinicopathologic diagnosis based on pretest clinical assessment aided by the 4T score and confirmed by laboratory testing for the presence of anti-heparin-platelet factor 4 antibody (HIT Ab). Prompt and accurate diagnosis of HIT is paramount due to an extraordinary high risk of thrombosis and the inherent risk of bleeding and cost with the use direct thrombin inhibitors (DTI). The polyspecific enzyme linked immunosorbent assay (poly-ELISA) for the HIT Ab is the most commonly available test that

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Szilágyi, Katalin, Beáta Flachner, István Hajdú, et al. "Rapid Identification of Potential Drug Candidates from Multi-Million Compounds’ Repositories. Combination of 2D Similarity Search with 3D Ligand/Structure Based Methods and In Vitro Screening." Molecules 26, no. 18 (2021): 5593. http://dx.doi.org/10.3390/molecules26185593.

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Rapid in silico selection of target focused libraries from commercial repositories is an attractive and cost-effective approach in early drug discovery. If structures of active compounds are available, rapid 2D similarity search can be performed on multimillion compounds’ databases. This approach can be combined with physico-chemical parameter and diversity filtering, bioisosteric replacements, and fragment-based approaches for performing a first round biological screening. Our objectives were to investigate the combination of 2D similarity search with various 3D ligand and structure-based met

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Rubbini, Gianluca, Ana Begoña Buades-Martín, María Kimatrai-Salvador та ін. "Lead optimization-hit expansion of new asymmetrical pyridinium/quinolinium compounds as choline kinase α1 inhibitors". Future Medicinal Chemistry 10, № 15 (2018): 1769–86. http://dx.doi.org/10.4155/fmc-2018-0059.

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19

Gupta-Ostermann, Disha, Jenny Balfer, and Jürgen Bajorath. "Hit Expansion from Screening Data Based upon Conditional Probabilities of Activity Derived from SAR Matrices." Molecular Informatics 34, no. 2-3 (2015): 134–46. http://dx.doi.org/10.1002/minf.201400164.

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PENGELLEY, DAVID, and FRANK WILLIAMS. "Sparseness for the symmetric hit problem at all primes." Mathematical Proceedings of the Cambridge Philosophical Society 158, no. 2 (2014): 269–74. http://dx.doi.org/10.1017/s0305004114000668.

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AbstractThe hit problem for a module over the Steenrod algebra $\mathcal{A}$ seeks a minimal set of $\mathcal{A}$-generators (“non-hit elements,” those not in the image of positive degree elements of $\mathcal{A}$). This problem has been studied for 25 years in a variety of contexts and, although general or complete results have been difficult to obtain, partial results have been obtained in many cases.For any prime p ⩾ 2, consider the algebra of symmetric polynomials in l variables over $\mathbb{F}$p (the cohomology of BU(l) [BO(l) for p = 2]). We prove a general sparseness result: For any l,

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Rajab, Omama, Kamal Ali, and Firas Al-Menshed. "Radiological and Geological Interpretation Using Radioactivity and Electrical Resistivity Data in the Hit–Kubaisa Vicinity, the Western Part of Iraq." Iraqi Geological Journal 58, no. 1C (2025): 208–18. https://doi.org/10.46717/igj.58.1c.16ms-2025-3-31.

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This study investigates current radioactivity levels in the Hit-Kubaisa area, Anbar Governorate, Iraq, considering recent population expansion and the development of unpaved roads and buildings. The research aims to assess radiation doses and environmental hazards, particularly in areas covered with recently supplied soil materials. Additionally, it seeks to understand the relationship between geological settings and natural radioactivity by integrating radiometric and resistivity surveys conducted in this study. Measurements of radiation exposure dose rates and total radioactivity were conduc

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Gulyaeva, Anastasia A., Andrey I. Sigorskih, Elena S. Ocheredko, Dmitry V. Samborskiy, and Alexander E. Gorbalenya. "LAMPA, LArge Multidomain Protein Annotator, and its application to RNA virus polyproteins." Bioinformatics 36, no. 9 (2020): 2731–39. http://dx.doi.org/10.1093/bioinformatics/btaa065.

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Abstract Motivation To facilitate accurate estimation of statistical significance of sequence similarity in profile–profile searches, queries should ideally correspond to protein domains. For multidomain proteins, using domains as queries depends on delineation of domain borders, which may be unknown. Thus, proteins are commonly used as queries that complicate establishing homology for similarities close to cutoff levels of statistical significance. Results In this article, we describe an iterative approach, called LAMPA, LArge Multidomain Protein Annotator, that resolves the above conundrum b

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23

Alkhalid, Farah Flayeh, Abdulhakeem Qusay Albayati, and Ahmed Ali Alhammad. "Expansion dataset COVID-19 chest X-ray using data augmentation and histogram equalization." International Journal of Electrical and Computer Engineering (IJECE) 12, no. 2 (2022): 1904. http://dx.doi.org/10.11591/ijece.v12i2.pp1904-1909.

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The main important factor that plays vital role in success the deep learning is the deep training by many and many images, if neural networks are getting bigger and bigger but the training datasets are not, then it sounds like going to hit an accuracy wall. Briefly, this paper investigates the current state of the art of approaches used for a data augmentation for expansion the corona virus disease 2019 (COVID-19) chest X-ray images using different data augmentation methods (transformation and enhancement) the dataset expansion helps to rise numbers of images from 138 to 5520, the increasing r

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Farah, Flayyeh Alkhalid, Qusay Albayati Abdulhakeem, and Ali Alhammad Ahmed. "Expansion dataset COVID-19 chest X-ray using data augmentation and histogram equalization." International Journal of Electrical and Computer Engineering (IJECE) 12, no. 2 (2022): 1904–9. https://doi.org/10.11591/ijece.v12i2.pp1904-1909.

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The main important factor that plays vital role in success the deep learning is the deep training by many and many images, if neural networks are getting bigger and bigger but the training datasets are not, then it sounds like going to hit an accuracy wall. Briefly, this paper investigates the current state of the art of approaches used for a data augmentation for expansion the corona virus disease 2019 (COVID-19) chest X-ray images using different data augmentation methods (transformation and enhancement) the dataset expansion helps to rise numbers of images from 138 to 5520, the increasing r

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25

Obie, Muhammad, Marina Pakaya, Mustakimah, and Syilfi. "OIL PALM EXPANSION AND LIVELIHOOD VULNERABILITY ON RURAL COMMUNITIES (A CASE IN POHUWATO REGENCY - INDONESIA)." Humanities & Social Sciences Reviews 8, no. 1 (2020): 01–12. http://dx.doi.org/10.18510/hssr.2020.811.

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Purpose: This study analyzed the expansion of oil palm and its impact on the livelihood vulnerability of rural communities. Furthermore, this study analyzed the livelihood base of rural communities, explained the mechanism of oil palm expansion controlling rural land, analyzed land tenure by oil palm expansion, which caused vulnerability to rural livelihoods, and analyzed the actions of rural peasants responding livelihood vulnerability due to oil palm expansion. Methodology: The researchers conducted observations inTaludisub district and Popayatosub district, both of which were location

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Braems, Elke, Bart Swinnen, and Ludo Van Den Bosch. "C9orf72 loss-of-function: a trivial, stand-alone or additive mechanism in C9 ALS/FTD?" Acta Neuropathologica 140, no. 5 (2020): 625–43. http://dx.doi.org/10.1007/s00401-020-02214-x.

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Abstract A repeat expansion in C9orf72 is responsible for the characteristic neurodegeneration in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) in a still unresolved manner. Proposed mechanisms involve gain-of-functions, comprising RNA and protein toxicity, and loss-of-function of the C9orf72 gene. Their exact contribution is still inconclusive and reports regarding loss-of-function are rather inconsistent. Here, we review the function of the C9orf72 protein and its relevance in disease. We explore the potential link between reduced C9orf72 levels and disease phenotypes

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Finch, NiCole A., Xue Wang, Matthew C. Baker, et al. "Abnormal expression of homeobox genes and transthyretin in C9ORF72 expansion carriers." Neurology Genetics 3, no. 4 (2017): e161. http://dx.doi.org/10.1212/nxg.0000000000000161.

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Objective:We performed a genome-wide brain expression study to reveal the underpinnings of diseases linked to a repeat expansion in chromosome 9 open reading frame 72 (C9ORF72).Methods:The genome-wide expression profile was investigated in brain tissue obtained from C9ORF72 expansion carriers (n = 32), patients without this expansion (n = 30), and controls (n = 20). Using quantitative real-time PCR, findings were confirmed in our entire pathologic cohort of expansion carriers (n = 56) as well as nonexpansion carriers (n = 31) and controls (n = 20).Results:Our findings were most profound in the

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Gelderblom, Hanneke, Henri Lhuissier, Alexander L. Klein, et al. "Drop deformation by laser-pulse impact." Journal of Fluid Mechanics 794 (April 6, 2016): 676–99. http://dx.doi.org/10.1017/jfm.2016.182.

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A free falling, absorbing liquid drop hit by a nanosecond laser pulse experiences a strong recoil pressure kick. As a consequence, the drop propels forward and deforms into a thin sheet which eventually fragments. We study how the drop deformation depends on the pulse shape and drop properties. We first derive the velocity field inside the drop on the time scale of the pressure pulse, when the drop is still spherical. This yields the kinetic energy partition inside the drop, which precisely measures the deformation rate with respect to the propulsion rate, before surface tension comes into pla

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Grant, Andrew. "Atom & cosmos: Growth of early universe gauged: Project measures expansion before dark energy hit the gas." Science News 182, no. 13 (2012): 9. http://dx.doi.org/10.1002/scin.5591821306.

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30

Jacobs, Robert Acton, Daniela Flück, Thomas Christian Bonne, et al. "Improvements in exercise performance with high-intensity interval training coincide with an increase in skeletal muscle mitochondrial content and function." Journal of Applied Physiology 115, no. 6 (2013): 785–93. http://dx.doi.org/10.1152/japplphysiol.00445.2013.

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Six sessions of high-intensity interval training (HIT) are sufficient to improve exercise capacity. The mechanisms explaining such improvements are unclear. Accordingly, the aim of this study was to perform a comprehensive evaluation of physiologically relevant adaptations occurring after six sessions of HIT to determine the mechanisms explaining improvements in exercise performance. Sixteen untrained (43 ± 6 ml·kg−1·min−1) subjects completed six sessions of repeated ( 8 – 12 ) 60 s intervals of high-intensity cycling (100% peak power output elicited during incremental maximal exercise test) i

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Hrustic, Hasiba. "A comparative analysis of models selected as a response to the world financial crisis." Medjunarodni problemi 61, no. 3 (2009): 244–73. http://dx.doi.org/10.2298/medjp0903244h.

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The financial crisis has hit the entire world economy. Many governments have been forced to rescue the financial systems, having as their priority to ensure economic recovery. A number of important measures have been taken to promote financial stability, including injection of capital into financial organizations, a substantial expansion of guarantees for bank liabilities by central banks, the recapitalization and the various liquidity programmes. However, the recovery has required a comprehensive plan to stabilize the financial system and restore normal flows of credit. The ultimate goal of t

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BASSAN, M., B. BUONOMO, G. CAVALLARI, et al. "MEASUREMENT OF THE THERMAL EXPANSION COEFFICIENT OF AN Al-Mg ALLOY AT ULTRA-LOW TEMPERATURES." International Journal of Modern Physics B 27, no. 22 (2013): 1350119. http://dx.doi.org/10.1142/s0217979213501191.

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We describe a result coming from an experiment based on an Al - Mg alloy (~5% Mg ) suspended bar hit by an electron beam and operated above and below the temperature of transition from superconducting to normal state of the material. The amplitude of the bar first longitudinal mode of oscillation, excited by the beam interacting with the bulk, and the energy deposited by the beam in the bar are the quantities measured by the experiment. These quantities, inserted in the equations describing the mechanism of the mode excitation and complemented by an independent measurement of the specific heat

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Jirarungsatian, Chalermkiat, Cherdpong Jomdecha, and Krisada Pojnsirisilp. "The Comparison of Acoustic Emission Activities between Material Integrity and Leakage during CNG Cylinder Testing." Key Engineering Materials 659 (August 2015): 638–43. http://dx.doi.org/10.4028/www.scientific.net/kem.659.638.

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The objective of this paper is to study the different acoustic emission (AE) activities from material integrity and leakage which were obtained from CNG steel cylinder during pressurization. CNG type I cylinders were employed to test by hydrostatic stressing. The pressure was continuously increased to over 1.1 time of operating pressure or leakage occurrences. AE sensors, resonance frequency of 150 kHz, were mounted on the outside cylinder wall to detect the AE activities throughout the testing. AE activities were compared between AE of material expansion and leakage by amount of AE signals de

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Turner-Bowker, D., J. Bjorner, M. DeRosa, et al. "Expansion of the Headache Impact Test (HIT ™) item pool & initial evaluation in a primary care setting." Journal of Pain 6, no. 3 (2005): S68. http://dx.doi.org/10.1016/j.jpain.2005.01.270.

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35

Lv, Qian, Liuxi Cai, Xiaoling Yu, Haihui Ma, Yun Li, and Yue Shu. "An Automatic Fault Diagnosis Method for the Reciprocating Compressor Based on HMT and ANN." Applied Sciences 12, no. 10 (2022): 5182. http://dx.doi.org/10.3390/app12105182.

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The health management of the reciprocating compressor is crucial for its long term steady operation and safety. Online condition monitoring technology for the reciprocating compressor is almost mature, whereas the fault diagnosis technologies are still insufficient to meet the need. Therefore, in this paper, a novel fault detection method for the reciprocating compressor based on digital image processing and artificial neural network (ANN) was proposed. This method is implemented to the sectionalized pressure–volume (p–V) curves, which are obtained by dividing a working cycle in the cylinder i

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Smeeding, Timothy M., Jennifer Romich, and Michael R. Strain. "The Long Recovery from the Great Recession: An Introduction." ANNALS of the American Academy of Political and Social Science 695, no. 1 (2021): 8–26. http://dx.doi.org/10.1177/00027162211036030.

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The first two decades of the twenty-first century have been marked by the Great Recession (GR), which was followed by the longest recovery in U.S. history, here termed the Long Recovery (LR). The LR lasted more than 10 years and ended with a pandemic bang in March 2020. This article introduces the eighteen articles that make up our review of the effects of the LR on the working class. What did more than a decade of economic expansion following the GR do for the working class and various groups of disadvantaged workers? We study this question through the lenses of economics, demography, sociolo

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Tomašič, Tihomir, Asta Zubrienė, Žiga Skok, et al. "Selective DNA Gyrase Inhibitors: Multi-Target in Silico Profiling with 3D-Pharmacophores." Pharmaceuticals 14, no. 8 (2021): 789. http://dx.doi.org/10.3390/ph14080789.

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DNA gyrase is an important target for the development of novel antibiotics. Although ATP-competitive DNA gyrase (GyrB) inhibitors are a well-studied class of antibacterial agents, there is currently no representative used in therapy, largely due to unwanted off-target activities. Selectivity of GyrB inhibitors against closely related human ATP-binding enzymes should be evaluated early in development to avoid off-target binding to homologous binding domains. To address this challenge, we developed selective 3D-pharmacophore models for GyrB, human topoisomerase IIα (TopoII), and the Hsp90 N-term

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Taylor-Fishwick, David A., Wenjing Shi, Gary L. Pittenger, and Aaron I. Vinik. "PDX-1 can repress stimulus-induced activation of the INGAP promoter." Journal of Endocrinology 188, no. 3 (2006): 611–21. http://dx.doi.org/10.1677/joe.1.06108.

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Islet neogenesis associated protein (INGAP) promotes the generation of new islet mass in adult animal models. It is not understood what factors control the expression of INGAP. In this study, factors that regulate the expression of INGAP promoter activity are reported. To determine factors that regulate INGAP expression, we previously cloned the promoter region for INGAP. Analysis of the INGAP promoter suggested that candidate regulators of INGAP expression include the transcription factors PDX-1, NeuroD, PAN-1, STAT and AP-1. Using gene addition experiments in the 293 cell line the activity o

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Khatri, Palash, and V. R. Sudindra. "Private Equity and Venture Capital – Preamble." Shanlax International Journal of Management 8, S1-Feb (2021): 133–37. http://dx.doi.org/10.34293/management.v8is1-feb.3766.

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Private equity investment can offer very strong returns in comparison to any stock market returns or public market investment opportunity.Private equity invests in companies which are not listed in the recognized stock exchange. Every business comes across six stages of the life cycle which include; Development, Start-up, early-stage growth, expansion, maturity, and decline/crisis stage. PE firms invest in the initial three stages. In today’s fast-moving world with technological changes very great business plan may hit by various events and successes of companies. Private equity not only inves

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Chen, Mio Sheng, Wu Lung Huang, Kuan Min Wu, and Chia Chun Tsai. "Qnew-Video Course Consultative System." Advanced Materials Research 655-657 (January 2013): 1839–42. http://dx.doi.org/10.4028/www.scientific.net/amr.655-657.1839.

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QNew is different from the common Internet video, for it shares the readers with its curriculum self-timer videos. It has the spirit of the open textbook-assisted learning. It also focuses on the uploading, sharing, and expansion of the users’ information. Typically, 5 to 10 minutes is the limit, as long as the teachers and students have finished registering, they can upload their videos of teaching. Website platform is composed of the sub-platform of course classification and message board, which furnishes the teachers and students with the service of Internet Hit.. QNew is the website mentio

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Nakano, Hirofumi, Tsukasa Hasegawa, Riyo Imamura, et al. "Development of a potent and selective FLT3 kinase inhibitor by systematic expansion of a non-selective fragment-screening hit." Bioorganic & Medicinal Chemistry Letters 26, no. 9 (2016): 2370–74. http://dx.doi.org/10.1016/j.bmcl.2016.03.006.

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Amer, Asmaa, Ahmed Nagah, Tianhai Tian, and Xinan Zhang. "Mutation Mechanisms of Breast Cancer among the Female Population in China." Current Bioinformatics 15, no. 3 (2020): 253–59. http://dx.doi.org/10.2174/1574893615666191220141548.

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Background: Cancer is a genetic disease caused by the accumulation of gene mutations. It is important to derive the number of driver mutations that are needed for the development of human breast cancer, which may provide insights into the tumor diagnosis and therapy. Objective: This work is designed to investigate whether there is any difference for the mutation mechanism of breast cancer between the patients in the USA and those in China. We study the mechanisms of breast cancer development in China, and then compare these mechanisms with those in the USA. Methods: This work designed a multis

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McLaren, Donna, Thorsten Gorba, Anita Marguerie de Rotrou, et al. "Automated Large-Scale Culture and Medium-Throughput Chemical Screen for Modulators of Proliferation and Viability of Human Induced Pluripotent Stem Cell–Derived Neuroepithelial-like Stem Cells." Journal of Biomolecular Screening 18, no. 3 (2012): 258–68. http://dx.doi.org/10.1177/1087057112461446.

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The aim of this study was to demonstrate proof-of-concept feasibility for the use of human neural stem cells (NSCs) for high-throughput screening (HTS) applications. For this study, an adherent human induced pluripotent stem (iPS) cell–derived long-term, self-renewing, neuroepithelial-like stem (lt-NES) cell line was selected as a representative NSC. Here, we describe the automated large-scale serum-free culture (“scale-up”) of human lt-NES cells on the CompacT SelecT cell culture robotic platform, followed by their subsequent automated “scale-out” into a microwell plate format. We also report

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Mandarino, Andrea, Francesco Faccini, Fabio Luino, Barbara Bono, and Laura Turconi. "Integrated Approach for the Study of Urban Expansion and River Floods Aimed at Hydrogeomorphic Risk Reduction." Remote Sensing 15, no. 17 (2023): 4158. http://dx.doi.org/10.3390/rs15174158.

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Urbanization in flood-prone areas is a critical issue worldwide. The historical floods, the urban expansion in terms of building footprint, the extent and construction period of inundated buildings with reference to two representative floods (5–6 November 1994 and 24–25 November 2016), and the ground effects and dynamics of these events were investigated in the cities of Garessio, Ceva, and Clavesana, along the Tanaro River (NW Italy). An integrated approach based on historical data analysis, photograph interpretation, field surveys, and GIS investigations was adopted, and novel metrics for qu

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Borisov, Denis I., and Oskar A. Sultanov. "Complete Asymptotics for Solution of Singularly Perturbed Dynamical Systems with Single Well Potential." Mathematics 8, no. 6 (2020): 949. http://dx.doi.org/10.3390/math8060949.

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We consider a singularly perturbed boundary value problem ( − ε 2 ∆ + ∇ V · ∇ ) u ε = 0 in Ω , u ε = f on ∂ Ω , f ∈ C ∞ ( ∂ Ω ) . The function V is supposed to be sufficiently smooth and to have the only minimum in the domain Ω . This minimum can degenerate. The potential V has no other stationary points in Ω and its normal derivative at the boundary is non-zero. Such a problem arises in studying Brownian motion governed by overdamped Langevin dynamics in the presence of a single attracting point. It describes the distribution of the points at the boundary ∂ Ω , at which the trajectories of th

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Sun, Shenfei, Ning Jiang, Yamei Jiang, et al. "Chromatin remodeler Znhit1 preserves hematopoietic stem cell quiescence by determining the accessibility of distal enhancers." Leukemia 34, no. 12 (2020): 3348–58. http://dx.doi.org/10.1038/s41375-020-0988-5.

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AbstractHematopoietic stem cell (HSC) utilizes its quiescence feature to combat exhaustion for lifetime blood cell supply. To date, how certain chromatin architecture and subsequent transcription profile permit HSC quiescence remains unclear. Here, we show an essential role of chromatin remodeler zinc finger HIT-type containing 1 (Znhit1) in maintaining HSC quiescence. We find that loss of Znhit1 leads to exhaustion of stem cell pool and impairment of hematopoietic function. Mechanically, Znhit1 determines the chromatin accessibility at distal enhancers of HSC quiescence genes, including Pten,

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K, Shajila Beegam M. "The Virtual Retinal Display: A Technology for Augmented Reality." International Journal for Research in Applied Science and Engineering Technology 11, no. 1 (2023): 287–91. http://dx.doi.org/10.22214/ijraset.2023.48544.

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Abstract: Virtual Retinal Display (VRD) is an advanced technology for creating visual images. Dr. Thomas A. Furness III created it at the Human Interface Technology Laboratory (HIT Lab). Low power laser light is directly scanned onto the retina by the VRD to produce images. Bright, high-contrast, high-resolution photos are produced with this unique technique. It has been shown that all the technological advancements needed have been made in order for small, laser-scanned, virtual retinal displays to operate effectively. Since several years ago, military and commercial customers have received p

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Chandrasiri, Sunil. "Empowering Sri Lankan Msmes: The Crucial Role of Skill Development in Fostering Future Tourism Growth." Sri Lanka Journal of Economic Research 11, no. 1 (2023): 105–13. http://dx.doi.org/10.4038/sljer.v11i1.198.

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Tourism is a strategically important industry for Sri Lanka, making a significant contribution to the crises that hit the island economy in terms of income generation, foreign exchange earnings, job creation, attracting foreign direct investment and high value-added growth. It is the only sector which has bounced back very strongly and has a high potential for growth and expansion. The MSMEs account for 80 per cent of business enterprises and 75 per cent of employment in the tourism industry, and its growth prospects are seriously impacted by skill gaps and shortages. This is mainly a supply-s

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Amaliya, Arina, Agus Supriono, Rizky Yanuarti, et al. "Proyeksi Produksi dan Konsumsi Gula Pasir di Indonesia 2022 2025 serta Implikasinya terhadap Target Swasembada Nasional." Journal of Agribusiness, Social and Economic 5, no. 1 (2025): 73–85. https://doi.org/10.32585/jase.v5i1.6656.

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Research aims to forecast sugar production and consumption in Indonesia for 2022–2025 and analyze its implications for the national self-sufficiency target by 2025. The research method employs ARIMA (Autoregressive Integrated Moving Average) time series analysis using secondary data from BPS and the Ministry of Agriculture (1990–2021). Results indicate that sugar production in 2025 is projected to reach 2.72 million tons, while consumption will hit 8.45 million tons, resulting in a mere 32.19% self-sufficiency rate (far below the 90% target). Key constraints include stagnant sugarcane acreage,

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Fernandez-Bustamante, Ana, Robert A. Parker, Juraj Sprung, et al. "An anesthesia-centered bundle to reduce postoperative pulmonary complications: The PRIME-AIR study protocol." PLOS ONE 18, no. 4 (2023): e0283748. http://dx.doi.org/10.1371/journal.pone.0283748.

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Background Postoperative pulmonary complications (PPCs) are a major cause of morbidity and mortality after open abdominal surgery. Optimized perioperative lung expansion may minimize the synergistic factors responsible for the multiple-hit perioperative pulmonary dysfunction. This ongoing study will assess whether an anesthesia-centered bundle focused on perioperative lung expansion results in decreased incidence and severity of PPCs after open abdominal surgery. Methods Prospective multicenter randomized controlled pragmatic trial in 750 adult patients with at least moderate risk for PPCs und

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