Academic literature on the topic 'HIV lifecycle'

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Journal articles on the topic "HIV lifecycle"

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Meducator, The. "The HIV Lifecycle." Meducator 1, no. 31 (2018): 29. http://dx.doi.org/10.15173/m.v1i31.1865.

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Wilflingseder, Doris. "Float on: lipid rafts in the lifecycle of HIV." Frontiers in Bioscience 12, no. 1 (2007): 2124. http://dx.doi.org/10.2741/2216.

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Tavassoli, Ali. "Targeting the protein–protein interactions of the HIV lifecycle." Chem. Soc. Rev. 40, no. 3 (2011): 1337–46. http://dx.doi.org/10.1039/c0cs00092b.

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Klingler, Jéromine, Halina Anton, Eléonore Réal, et al. "How HIV-1 Gag Manipulates Its Host Cell Proteins: A Focus on Interactors of the Nucleocapsid Domain." Viruses 12, no. 8 (2020): 888. http://dx.doi.org/10.3390/v12080888.

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The human immunodeficiency virus (HIV-1) polyprotein Gag (Group-specific antigen) plays a central role in controlling the late phase of the viral lifecycle. Considered to be only a scaffolding protein for a long time, the structural protein Gag plays determinate and specific roles in HIV-1 replication. Indeed, via its different domains, Gag orchestrates the specific encapsidation of the genomic RNA, drives the formation of the viral particle by its auto-assembly (multimerization), binds multiple viral proteins, and interacts with a large number of cellular proteins that are needed for its func
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Peate, Ian. "Understanding HIV – A guide for primary care nurses." Practice Nursing 35, no. 10 (2024): 330–37. https://doi.org/10.12968/pnur.2024.35.10.330.

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The treatment and management of patients with HIV and AIDS has made huge progress, with clinicians now often managing the condition alongside coexisting long terms needs and the frailty of old age. This article provides an insight into Human Immunodeficiency Virus (HIV). A brief overview of HIV is offered along with a discussion of the virus, a definition and the basic biology of HIV, its structure and types. The lifecycle of the virus is outlined as well as its impact on the immune system and how HIV affects the body. The importance of HIV testing in early detection and prevention is describe
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Rosas, Scott R., Jeffrey T. Schouten, Dennis Dixon, et al. "Evaluating protocol lifecycle time intervals in HIV/AIDS clinical trials." Clinical Trials: Journal of the Society for Clinical Trials 11, no. 5 (2014): 553–59. http://dx.doi.org/10.1177/1740774514540814.

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Price, Amanda, David Jacques, Sebastian Essig, et al. "HIV-1 capsid binds host cofactors to mediate nuclear import." Acta Crystallographica Section A Foundations and Advances 70, a1 (2014): C120. http://dx.doi.org/10.1107/s2053273314098799.

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The capsid (CA) protein of HIV-1, which forms the core of the virus, has been shown to have an increasingly important role in the early stages of the virus lifecycle, in particular during reverse transcription and nuclear import. We recently solved the structure of a fragment of the human cofactor CPSF6 in complex with the N-terminal domain of HIV-1 CA, revealing a previously unknown interface used by the virus to recruit CPSF6, which is required for the virus to successfully complete the early stages of its lifecycle. Using a recently developed hexameric unit of CA, we have solved the structu
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Heredia, Alonso, Nhut Le, Ronald B. Gartenhaus, et al. "Targeting of mTOR catalytic site inhibits multiple steps of the HIV-1 lifecycle and suppresses HIV-1 viremia in humanized mice." Proceedings of the National Academy of Sciences 112, no. 30 (2015): 9412–17. http://dx.doi.org/10.1073/pnas.1511144112.

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HIV necessitates host factors for successful completion of its life cycle. Mammalian target of rapamycin (mTOR) is a conserved serine/threonine kinase that forms two complexes, mTORC1 and mTORC2. Rapamycin is an allosteric inhibitor of mTOR that selectively inhibits mTORC1. Rapamycin interferes with viral entry of CCR5 (R5)-tropic HIV and with basal transcription of the HIV LTR, potently inhibiting replication of R5 HIV but not CXCR4 (X4)-tropic HIV in primary cells. The recently developed ATP-competitive mTOR kinase inhibitors (TOR-KIs) inhibit both mTORC1 and mTORC2. Using INK128 as a protot
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Roxby, Alison C., Jennifer A. Unger, Jennifer A. Slyker, et al. "A Lifecycle Approach to HIV Prevention in African Women and Children." Current HIV/AIDS Reports 11, no. 2 (2014): 119–27. http://dx.doi.org/10.1007/s11904-014-0203-2.

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Tavassoli, Ali. "ChemInform Abstract: Targeting the Protein-Protein Interactions of the HIV Lifecycle." ChemInform 42, no. 27 (2011): no. http://dx.doi.org/10.1002/chin.201127257.

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Dissertations / Theses on the topic "HIV lifecycle"

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Roger, Jonathan C. "Analyzing the role of NonO, a host protein, in the HIV-1 lifecycle." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1394705150.

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De, Villiers William Murray. "Aspects of the South African music industry : an analytical perspective." Diss., 2007. http://hdl.handle.net/2263/27324.

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The music industry worldwide is rapidly evolving as a result of commercial, technological and demographic developments. The magnitude of the strategic impact of these developments on the South African music industry is evaluated in terms of internal and external factors, such as the intrinsic industry growth levels, ability to adapt to change, the consumer buying power, audio-visual piracy and counterfeiting, literacy, employment and the prevalence of HIV/AIDS. Collected data from public domain and proprietary music industry sources are transformed and presented in terms of the competitiveness
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Venugopal, Vishnu. "Modelling How Refractoriness to Interferon Compromises Interferon-Free Treatment of Hepatitis C Virus Infection." Thesis, 2017. http://etd.iisc.ac.in/handle/2005/3612.

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Hepatitis C virus (HCV) infection globally affects 130-150 million people. It causes both acute and chronic infections. Due to the severe side effects and low success rates of interferon based treatments, which formed the standard treatment for HCV, the treatment paradigm shifted to direct acting antivirals (DAAs). DAAs have revolutionized the treatment of hepatitis C virus infection. Clinical trials with combinations of DAAs have recorded >90% response with shorter treatment durations and fewer side effects than earlier treatments involving IFN. Outside the controlled setting of a clinical t
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Venugopal, Vishnu. "Modelling How Refractoriness to Interferon Compromises Interferon-Free Treatment of Hepatitis C Virus Infection." Thesis, 2017. http://etd.iisc.ernet.in/2005/3612.

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Hepatitis C virus (HCV) infection globally affects 130-150 million people. It causes both acute and chronic infections. Due to the severe side effects and low success rates of interferon based treatments, which formed the standard treatment for HCV, the treatment paradigm shifted to direct acting antivirals (DAAs). DAAs have revolutionized the treatment of hepatitis C virus infection. Clinical trials with combinations of DAAs have recorded >90% response with shorter treatment durations and fewer side effects than earlier treatments involving IFN. Outside the controlled setting of a clinical t
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Book chapters on the topic "HIV lifecycle"

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Andrasik, Michele, Gail Broder, Linda Oseso, et al. "18.1 In Practice: Building Community Engagement for Clinical Research Response." In Principles and Practice of Emergency Research Response. Springer International Publishing, 2024. http://dx.doi.org/10.1007/978-3-031-48408-7_26.

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AbstractThis in-practice text provides examples of progressive community engagement that lays the groundwork for an emergency clinical research response in case of need. Community engagement via good participatory practice (GPP) enables sharing information and perspectives among community members, researchers, research sponsors, and other stakeholders throughout the clinical trial lifecycle. It builds and maintains relationships and partnerships between the research team and the wider community through bidirectional communication and reciprocity. Real-world examples of community engagement inc
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Tenente, Marcos, Carla Henriques, Álvaro Gomes, Patrícia Pereira da Silva, and António Trigo. "Multiple Impacts of Energy Efficiency Technologies in Portugal." In Springer Proceedings in Political Science and International Relations. Springer Nature Switzerland, 2022. http://dx.doi.org/10.1007/978-3-031-18161-0_9.

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AbstractPortuguese programs aimed at fostering Energy Efficiency (EE) measures often rely on cost–benefit approaches only considering the use phase and neglecting other potential impacts generated. Therefore, this work suggests a novel methodological framework by combining Hybrid Input–Output Lifecycle Analysis (HIO-LCA) with the Portuguese seasonal method for computing the households’ energy needs. A holistic assessment of the energy, economic, environmental, and social impacts connected with the adoption of EE solutions is conducted aimed at supporting decision-makers (DMs) in the design of
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CAMPBELL, ANDY. "HIV Lifecycle Model." In Queer Communion. Intellect Books, 2020. http://dx.doi.org/10.2307/j.ctv36xw1b1.59.

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L. Wale, Janet, and Dominique Hamerlijnck. "Perspective Chapter: Patient Advocacy - From a Seat at the Table to Equal Stakeholders." In Economics of Healthcare, Studies and Cases [Working Title]. IntechOpen, 2024. http://dx.doi.org/10.5772/intechopen.1005513.

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Much has changed in individual and policy level patient advocacy in the years since the late 1980s when HIV/AIDS activists challenged the United States medical product regulator and aspects of how randomised controlled trials are conducted. Delays in access to innovative, life-saving medical interventions continue to be a key topic. We provide storylines to explore three interrelated pathways. The first follows the involvement of patients in the medical product lifecycle and clinical trial regulation, where the biopharmaceutical industry is a major stakeholder. The second follows the course of
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Borycki Elizabeth M. and Kushniruk Andre W. "Scenario-based Testing of Health Information Systems (HIS) in Electronic and Hybrid Environments." In Studies in Health Technology and Informatics. IOS Press, 2009. https://doi.org/10.3233/978-1-58603-979-0-284.

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Researchers have identified sources of technology-induced errors involving health information systems (HIS) across the software development lifecycle. In this paper the authors review approaches to identifying technology-induced error and describe, compare and contrast the advantages and disadvantages of using predictive and post-implementation methodologies to identify technology-induced error. Following this, the authors focus upon clinical simulations using scenario-based testing as a methodology for diagnosing technology-induced errors to assess HIS ability to respond to the stresses and s
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Marcilly Romaric, Kushniruk Andre W., Beuscart-Zephir Marie-Catherine, and Borycki Elizabeth M. "Insights and limits of usability evaluation methods along the health information technology lifecycle." In Studies in Health Technology and Informatics. IOS Press, 2015. https://doi.org/10.3233/978-1-61499-512-8-115.

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A great variety of usability evaluation methods exist but they do not provide the same kind of results and do not address the same stage of the Health Information Technology (HIT) lifecycle. This paper takes stock of the application of expert evaluation, usability testing, clinical simulation, clinical trials and post-implementation surveillance to provide an overview of their main similarities and differences. Results from this comparison will help in choosing methods that are best able to evaluate a HIT and improve its usability and ultimately its safety of use.
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Usselman Erin, Borycki Elizabeth M., and Kushniruk Andre W. "The Evaluation of Electronic Perioperative Nursing Documentation Using a Cognitive Walkthrough Approach." In Studies in Health Technology and Informatics. IOS Press, 2015. https://doi.org/10.3233/978-1-61499-488-6-331.

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Health Information System (HIS) implementations are on the rise in North America as the result of increased investment by governments. According to the evidence, systems not only have the potential to introduce error, but poorly designed user interfaces can result in systems that are not usable and possibly unsafe. Therefore, the need to evaluate HIS during the early phases of the system development lifecycle is becoming increasingly important. Researchers have begun to propose usability engineering methods that can be applied to help evaluate systems during design and development using an ite
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Mludek Volker, Wolff Astrid Corinna, van der Haak Minne, et al. "Supporting Clinical Practice Guidelines: Lifecycle of Guidelines for Oncology within an XML-based Guideline Framework." In Studies in Health Technology and Informatics. IOS Press, 2002. https://doi.org/10.3233/978-1-60750-934-9-466.

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Clinical Practice Guidelines (CPGs) have become important instruments for supporting patient care. Many structure models for CPGs have been developed to explicitly gain structured CPG documents, some of them using XML. Often, however, problems arise in filling these structures with content and integrating CPG applications into an EPR/HIS The Universities of Giefien and Heidelberg have each presented an XML-based CPG structure, which are actually being merged into one. The obtained CPG structure will build our common “xCPG core model” embedded in an “XML framework&
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Siems, Florian U., and Dominik Walcher. "The Life Event Cycle." In Mass Customization for Personalized Communication Environments. IGI Global, 2010. http://dx.doi.org/10.4018/978-1-60566-260-2.ch001.

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In this chapter it is argued that service stores most often offer standardized services, which may not hit the customers’ demands. As a new possibility to customize service offerings the life event cycle is introduced, which builds on traditional lifecycle concepts but refines them by a stronger individual perspective. In the first part of the chapter, a short introduction in service management, kinds of services and the relevance of a long term customer relationship for service stores is given. Then the idea of life cycles is shown in general, before in the main part the life event cycle is e
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Kng, Chun Keat, Pantea Keikhosrokiani, and Moussa Pourya Asl. "Artificial Intelligence and Human Rights Activism." In Advances in Computational Intelligence and Robotics. IGI Global, 2022. http://dx.doi.org/10.4018/978-1-6684-6242-3.ch006.

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Behrouz Boochani, the Kurdish-Iranian author of No Friends But the Mountains, has been using social media platforms such as Twitter to speak up against social injustice and human rights abuse against immigrants across the globe. This study proposes an artificial intelligence lifecycle for opinion mining of the dominant sentiments, topics, and emotions in Boochani's social media activism. Sentiment analysis (Vader and Textblob), topic modelling (LDA and NMF), and emotion detection are performed to extract hidden sentiments, topics, and emotions from the data that is collected from his tweets fr
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Conference papers on the topic "HIV lifecycle"

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Pollard, Lee, Adrian Belanger, and Tim Clarke. "Managing HIC Affected Pipelines Utilizing MFL Hard Spot Technology." In CORROSION 2004. NACE International, 2004. https://doi.org/10.5006/c2004-04172.

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Abstract When a pipeline operator considers the concept of pipeline integrity, conventional wisdom has led operators to believe that evaluation techniques should only be concerned with processes or conditions that may have affected pipeline integrity during the construction or operation phases of a pipeline's lifecycle. Due to unfortunate circumstances, pipeline incidents have become increasingly prevalent and the causation has not solely been attributed to these two factors. Non-homogeneous structural pipeline conditions created during the milling process have become an issue that pipeline op
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Khramtsova, Maria, and Dmitry Wiebe. "Observable signatures of lifecycle of PAHs in HII complexes." In The Life Cycle of Dust in the Universe: Observations, Theory, and Laboratory Experiments. Sissa Medialab, 2014. http://dx.doi.org/10.22323/1.207.0123.

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Liu, Huiyan, Xueying Wang, and Qqizhe Quan. "Research on the Enterprise' Model of Information Lifecycle Management Based on Enterprise Architecture." In 2009 Ninth International Conference on Hybrid Intelligent Systems. IEEE, 2009. http://dx.doi.org/10.1109/his.2009.246.

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Fallin, T. Wade, and Deborah L. Thurston. "Decision Decomposition for the Lifecycle of the Design Process." In ASME 1994 Design Technical Conferences collocated with the ASME 1994 International Computers in Engineering Conference and Exhibition and the ASME 1994 8th Annual Database Symposium. American Society of Mechanical Engineers, 1994. http://dx.doi.org/10.1115/detc1994-0149.

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Abstract Expanding design analysis to include lifecycle considerations makes design decision making more complex. This paper presents a methodology for structuring the lifecycle of the design decision making process itself in order to efficiently utilize designers’ time. The first step involves organizing performance objectives and decision variables into a hierarchical matrix structure defining the design space. Then, vertex partitioning is performed on a graph representation of the design space to delineate distinct stages where only a subset of decision variables are analyzed. An example of
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Kain, Sebastian, Frank Schiller, and Sven Dominka. "Reuse of models in the lifecycle of production plants using HiL simulation models for diagnosis." In 2008 IEEE International Symposium on Industrial Electronics (ISIE 2008). IEEE, 2008. http://dx.doi.org/10.1109/isie.2008.4677244.

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Elmagdoub, Abdelrahman W. M., Joris Simaitis, Mattias Halmearo, et al. "Freevalve: A Comparative GWP Life Cycle Assessment of E-fuel Fully Variable Valvetrain-equipped Hybrid Electric Vehicles and Battery Electric Vehicles." In WCX SAE World Congress Experience. SAE International, 2023. http://dx.doi.org/10.4271/2023-01-0555.

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<div class="section abstract"><div class="htmlview paragraph">Throughout its history, the internal combustion engine has been continuously scrutinized to achieve strict legislative emission targets. With the dawn of renewable fuels fast approaching, most Internal Combustion Engine (ICE) equipped hybrid electric vehicles (HEVs) face difficulty in adjusting their precise control strategies to new fuels. This is partly due to constrained limitations associated with camshaft-induced design-point air induction limitations. Freevalve is a fully variable valvetrain technology enabling ind
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Baiashvili, Beka. "Circular Economy - The Way to Survive in a Post-pandemic Situation." In Challenges in Economics and Business in the Post-COVID Times. University of Maribor Press, 2022. http://dx.doi.org/10.18690/um.epf.5.2022.1.

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The crisis caused by coronavirus has hit the world economy and business sector particularly hard. The recovery process after this crisis will not be easy. The circular economy has become one of the most crucial discussion topics globally. It can help countries overcome the emerging economic problem caused by the coronavirus pandemic. The circular economy is a production and consumption model which involves sharing,leasing, reusing, repairing, refurbishing and recycling existing materials and products for as long as possible, thus extending the lifecycle of products. According to preliminary es
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Fritsch, Klaus. "GWP® - The Weighing Standard: Why We Should Challenge the Established Way We Calibrate and Test Weighing Instruments." In NCSL International Workshop & Symposium. NCSL International, 2013. http://dx.doi.org/10.51843/wsproceedings.2013.35.

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In the pharmaceutical laboratory, weighing is only one step of a whole analysis chain in drug discovery and quality control; however it strongly influences the overall quality and integrity of the final result. Also in production, weighing is decisive to achieve batch uniformity and consistency, e.g. in dispensing or formulation processes. For the food industry, accurate weighing processes also act as an important contribution for two of its most demanding challenges: Increasing public health and consumer safety, and increasing productivity and competitiveness. The same or similar issues are a
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Cox, Chase D., and Nanci Hardwick. "A Novel Solid-State Additive Manufacturing Technology in Support of Turbomachinery Sustainment." In ASME Turbo Expo 2019: Turbomachinery Technical Conference and Exposition. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/gt2019-91419.

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Abstract Maintenance, repair, and overhaul activities are necessary and critical, often repeated, operations which occur during the lifecycle of turbomachinery components and assemblies. The ability to extend the life and performance of parts via sustainment type activities currently in service offers a significant and beneficial financial impact for both the manufacturers of these components as well as their end-users. Additive manufacturing not only enables manufacturers the ability to “print” complex geometries in a wide array of materials including metals but, in some instances, also offer
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Teixeira, André, João Pedro Polito, Júlio Santos, and Marcos Kakitani. "Competition, research and extension: the three approaches to the popularization of small satellites in the Alto Paraopeba region in Brazil." In Symposium on Space Educational Activities (SSAE). Universitat Politècnica de Catalunya, 2022. http://dx.doi.org/10.5821/conference-9788419184405.124.

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There are several approaches to the diffusion of the space technologies, three of them are in this work: competition, research, and extension. Thus, the objective of this work is to focus on presenting the results of the Brazilian nanosatellite team called NoizOrbita, and also to qualify quantitatively the impact of using these approaches in popularizing the topic of small satellites for space educational purposes. The team was founded on September 29, 2020, by three people: an alumni of Telecommunications Engineering at Federal University of São João del- Rei (UFSJ), Alto Paraopeba Campus (CA
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