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Journal articles on the topic 'Hormone immune networks'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Meik, Kunz, Ahmed Nazeer, Dandekar Thomas, and Naseem Muhammad. "Hormone Signaling Networks Open Multiple Routes for Immunity and Disease in Plants." Biohelikon 1, no. 2 (2013): 1–3. https://doi.org/10.5281/zenodo.816323.

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Plant hormones are small signaling molecules that regulate almost every aspect of plant life cycle. Plant pathogens alter hormonal balance of the host to cause disease. In response, host redefines hormone signaling networks to cope with the invading pathogen. Biotrophic pathogens are generally sensitive to salicylic acid mediated defense responses, whereas necrotrophic pathogens are deterred through jasmonate/ethylene pathways. Interaction between these pathways is regarded as central backbone of plant immunity. Classic hormones such as auxin, gibberellin, and cytokinin either promote salicyli

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Keith, Scott A. "Steroid hormone regulation of innate immunity in Drosophila melanogaster." PLOS Genetics 19, no. 6 (2023): e1010782. http://dx.doi.org/10.1371/journal.pgen.1010782.

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Endocrine signaling networks control diverse biological processes and life history traits across metazoans. In both invertebrate and vertebrate taxa, steroid hormones regulate immune system function in response to intrinsic and environmental stimuli, such as microbial infection. The mechanisms of this endocrine-immune regulation are complex and constitute an ongoing research endeavor facilitated by genetically tractable animal models. The 20-hydroxyecdysone (20E) is the major steroid hormone in arthropods, primarily studied for its essential role in mediating developmental transitions and meta

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Dan, Song, and Shi Yichao. "Immune system modifications and feto-maternal immune tolerance." Chinese Medical Journal 127, no. 17 (2014): 3171–80. http://dx.doi.org/10.3760/cma.j.issn.0366-6999.20133072.

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Objective This review aimed at understanding pregnancy-induced changes in the maternal immune response and mechanisms for the establishment of feto-maternal tolerance. Data sources Articles cited in this review were obtained from PubMed in English from 2000 to 2014, and the search string included keywords such as feto-maternal tolerance, dendritic cells, macrophage, T regulatory cells, natural killer cells, cytokines and hormone. Study selection Articles regarding altered maternal immune response, including the proliferation and differentiation of the altered cells, and the production of cytok

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Naseem, Muhammad, Meik Kunz, and Thomas Dandekar. "Probing the Unknowns in Cytokinin-Mediated Immune Defense in Arabidopsis with Systems Biology Approaches." Bioinformatics and Biology Insights 8 (January 2014): BBI.S13462. http://dx.doi.org/10.4137/bbi.s13462.

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Plant hormones involving salicylic acid (SA), jasmonic acid (JA), ethylene (Et), and auxin, gibberellins, and abscisic acid (ABA) are known to regulate host immune responses. However, plant hormone cytokinin has the potential to modulate defense signaling including SA and JA. It promotes plant pathogen and herbivore resistance; underlying mechanisms are still unknown. Using systems biology approaches, we unravel hub points of immune interaction mediated by cytokinin signaling in Arabidopsis. High-confidence Arabidopsis protein—protein interactions (PPI) are coupled to changes in cytokinin-medi

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Wang, Hongtao, and Zhiming Xie. "Cullin-Conciliated Regulation of Plant Immune Responses: Implications for Sustainable Crop Protection." Plants 13, no. 21 (2024): 2997. http://dx.doi.org/10.3390/plants13212997.

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Cullins are crucial components of the ubiquitin–proteasome system, playing pivotal roles in the regulation of protein metabolism. This review provides insight into the wide-ranging functions of cullins, particularly focusing on their impact on plant growth, development, and environmental stress responses. By modulating cullin-mediated protein mechanisms, researchers can fine-tune hormone-signaling networks to improve various agronomic traits, including plant architecture, flowering time, fruit development, and nutrient uptake. Furthermore, the targeted manipulation of cullins that are involved

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Bright, John J., Saravanan Kanakasabai, Wanida Chearwae, and Sharmistha Chakraborty. "PPAR Regulation of Inflammatory Signaling in CNS Diseases." PPAR Research 2008 (2008): 1–12. http://dx.doi.org/10.1155/2008/658520.

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Central nervous system (CNS) is an immune privileged site, nevertheless inflammation associates with many CNS diseases. Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear hormone receptors that regulate immune and inflammatory responses. Specific ligands for PPAR, , and isoforms have proven effective in the animal models of multiple sclerosis (MS), Alzheimer's disease, Parkinson's disease, and trauma/stroke, suggesting their use in the treatment of neuroinflammatory diseases. The activation of NF-B and Jak-Stat signaling pathways and secretion of inflammatory cytokines

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Nagy, Laszlo, Attila Szanto, Istvan Szatmari, and Lajos Széles. "Nuclear Hormone Receptors Enable Macrophages and Dendritic Cells to Sense Their Lipid Environment and Shape Their Immune Response." Physiological Reviews 92, no. 2 (2012): 739–89. http://dx.doi.org/10.1152/physrev.00004.2011.

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A key issue in the immune system is to generate specific cell types, often with opposing activities. The mechanisms of differentiation and subtype specification of immune cells such as macrophages and dendritic cells are critical to understand the regulatory principles and logic of the immune system. In addition to cytokines and pathogens, it is increasingly appreciated that lipid signaling also has a key role in differentiation and subtype specification. In this review we explore how intracellular lipid signaling via a set of transcription factors regulates cellular differentiation, subtype s

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Ribarac-Stepic, Nevena, Snezana Djurica, Zorica Zakula, Goran Koricanac, and Dragoslav Milosevic. "Molecular basis of glucocorticoid action." Srpski arhiv za celokupno lekarstvo 133, Suppl. 1 (2005): 61–66. http://dx.doi.org/10.2298/sarh05s1061r.

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Glucocorticoid hormones are involved in regulation of cell processes and coordinate physiological response to diverse signals. These hormones, through interaction with specific intracellular receptors, coordinate components of physiological repertoires by activating the expression of gene networks. Thus hormone-receptor complexes may function as key constituent in regulation of specific cell functions as well as in provoking differentiation in already determined cells. Analysis of steroid receptors are important for understanding of molecular details of transcriptional control as well as provi

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McKinney, Lawrence P., Rajesh Singh, I. King Jordan, Sooryanarayana Varambally, Eric B. Dammer, and James W. Lillard. "Transcriptome Analysis Identifies Tumor Immune Microenvironment Signaling Networks Supporting Metastatic Castration-Resistant Prostate Cancer." Onco 3, no. 2 (2023): 81–95. http://dx.doi.org/10.3390/onco3020007.

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Prostate cancer (PCa) is the second most common cause of cancer death in American men. Metastatic castration-resistant prostate cancer (mCRPC) is the most lethal form of PCa and preferentially metastasizes to the bones through incompletely understood molecular mechanisms. Herein, we processed RNA sequencing data from patients with mCRPC (n = 60) and identified 14 gene clusters (modules) highly correlated with mCRPC bone metastasis. We used a novel combination of weighted gene co-expression network analysis (WGCNA) and upstream regulator and gene ontology analyses of clinically annotated transc

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Zhu, Wenyong, Hao Huang, Zixi Hu, et al. "Comprehensive Transcriptome Analysis Expands lncRNA Functional Profiles in Breast Cancer." International Journal of Molecular Sciences 25, no. 15 (2024): 8456. http://dx.doi.org/10.3390/ijms25158456.

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Breast cancer is a heterogeneous disease that arises as a multi-stage process involving multiple cell types. Patients diagnosed with the same clinical stage and pathological classification may have different prognoses and therapeutic responses due to alterations in molecular genetics. As an essential marker for the molecular subtyping of breast cancer, long non-coding RNAs (lncRNAs) play a crucial role in gene expression regulation, cell differentiation, and the maintenance of genomic stability. Here, we developed a modular framework for lncRNA identification and applied it to a breast cancer

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Tam, Neville N. C., Carol Y. Y. Szeto, Johannes M. Freudenberg, Amy N. Fullenkamp, Mario Medvedovic, and Shuk-Mei Ho. "Research Resource: Estrogen-Driven Prolactin-Mediated Gene-Expression Networks in Hormone-Induced Prostatic Intraepithelial Neoplasia." Molecular Endocrinology 24, no. 11 (2010): 2207–17. http://dx.doi.org/10.1210/me.2010-0179.

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Abstract Cotreatment with testosterone (T) and 17β-estradiol (E2) is an established regimen for inducing of prostatic intraepithelial neoplasia (PIN) and prostate cancer in rodent models. We previously used the pure antiestrogen ICI 182,780 (ICI) and bromocriptine, a dopamine receptor agonist, to inhibit PIN induction and systemic hyperprolactinemia in Noble rats and found that the carcinogenic action of T+E2 is mediated directly by the effects of E2 on the prostate and/or indirectly via E2-induced hyperprolactinemia. In this study, we delineate the specific action(s) of E2 and prolactin (PRL)

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Kim, Hyung Suk, Min Gyu Kim, Kyueng-Whan Min, Un Suk Jung, and Dong-Hoon Kim. "High MMP-11 expression associated with low CD8+ T cells decreases the survival rate in patients with breast cancer." PLOS ONE 16, no. 5 (2021): e0252052. http://dx.doi.org/10.1371/journal.pone.0252052.

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Matrix metalloproteinase-11 (MMP-11) promote cancer invasion and metastasis through degrading the extracellular matrix. Protein degradation by MMP-11 in tumor cells may progressively suppress cancer surveillance activities with blocking immune response in breast cancer. The aim of study is to analyze clinicopathological parameters, molecular interactions and anticancer immune response in patients with MMP-11 expression and to provide candidate target drugs. We investigated the clinicopathologic parameters, specific gene sets, tumor antigenicity, and immunologic relevance according to MMP-11 ex

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Aşır, Fırat, Senem Çetin Duran, Muhammet Afşin, Enis Duran, Tuğcan Korak, and Fırat Şahin. "Investigation of Vitamin D Levels in Men with Suspected Infertility." Life 14, no. 2 (2024): 273. http://dx.doi.org/10.3390/life14020273.

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Male infertility may be caused by an impaired sperm functionality, with insufficient vitamin D levels affecting the quantity and development of motile sperm. Given the influence of vitamin D on vital aspects of male infertility, this study aimed to investigate the correlation between vitamin D levels and male infertility, along with exploring the possible mechanism of action. A total of 306 male participants were included. Semen samples were collected and analyzed for semen parameters with demographic features. Patients were classified into two groups based on vitamin D levels of <20 ng/mL

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Michalik, Liliane, and Walter Wahli. "PPARs Mediate Lipid Signaling in Inflammation and Cancer." PPAR Research 2008 (2008): 1–15. http://dx.doi.org/10.1155/2008/134059.

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Lipid mediators can trigger physiological responses by activating nuclear hormone receptors, such as the peroxisome proliferator-activated receptors (PPARs). PPARs, in turn, control the expression of networks of genes encoding proteins involved in all aspects of lipid metabolism. In addition, PPARs are tumor growth modifiers, via the regulation of cancer cell apoptosis, proliferation, and differentiation, and through their action on the tumor cell environment, namely, angiogenesis, inflammation, and immune cell functions. Epidemiological studies have established that tumor progression may be e

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Chen, Jian, Michael Clinton, Guang Qi, Daowen Wang, Fengquan Liu, and Zheng Qing Fu. "Reprogramming and remodeling: transcriptional and epigenetic regulation of salicylic acid-mediated plant defense." Journal of Experimental Botany 71, no. 17 (2020): 5256–68. http://dx.doi.org/10.1093/jxb/eraa072.

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Abstract As a plant hormone, salicylic acid (SA) plays essential roles in plant defense against biotrophic and hemibiotrophic pathogens. Significant progress has been made in understanding the SA biosynthesis pathways and SA-mediated defense signaling networks in the past two decades. Plant defense responses involve rapid and massive transcriptional reprogramming upon the recognition of pathogens. Plant transcription factors and their co-regulators are critical players in establishing a transcription regulatory network and boosting plant immunity. A multitude of transcription factors and epige

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Zhang, Zeyu, Tongyu Fu, Cong Zhou, et al. "Genome-Wide Analysis of the PERK Gene Family in Brassica napus L. and Their Potential Roles in Clubroot Disease." International Journal of Molecular Sciences 26, no. 6 (2025): 2685. https://doi.org/10.3390/ijms26062685.

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The proline-rich extensin-like receptor kinase (PERK) gene family is crucial to various molecular and cellular processes in plants. We identified 50 PERK genes in Brassica napus to explore their evolutionary dynamics, structural diversity, and functional roles. These genes were grouped into four classes and unevenly distributed across 18 chromosomes. Phylogenetic studies and Ka/Ks ratios revealed purifying selection during the evolution process. They exhibited significant diversification in gene length, molecular weight, and isoelectric points, suggesting specialized function. Gene structure a

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Kapic, Ammar, Khadiza Zaman, Vien Nguyen, Katalin Prokai-Tatrai, and Laszlo Prokai. "Identification of Estrogen-Responsive Proteins in Mouse Seminal Vesicles Through Mass Spectrometry-Based Proteomics." Pharmaceuticals 17, no. 11 (2024): 1508. http://dx.doi.org/10.3390/ph17111508.

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Background: Although estrogenic compounds promise therapeutic potential in treating various conditions, concerns regarding their endocrine-disrupting effects have been raised. Current methodologies for screening estrogenicity in rodent models are limited to the female-specific uterotrophic bioassay. Studies have reported enlargement of the seminal vesicles in orchiectomized males treated with estrogens. However, identifying estrogenicity strictly through changes in wet weights is uninformative regarding the molecular mechanisms of these agents. Therefore, protein-based biomarkers can complemen

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Greiner, E. F., S. Berger, and G. Schütz. "Genetic dissection of gluco- and mineralocorticoid receptor function in mice." Pure and Applied Chemistry 75, no. 11-12 (2003): 1699–707. http://dx.doi.org/10.1351/pac200375111699.

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Nuclear hormone receptors function to transduce hormonal signals into transcriptional responses by controlling the activity of specific target genes. These target genes comprise a genetic network whose coordinate activity defines the physiological responses to hormonal signals. Dissecting nuclear hormone receptor functions in vivo by gene inactivation and transgenic strategies represents an invaluable and powerful approach to increase our knowledge of these genetic networks and their physiological functions. Glucocorticoids and mineralocorticoids are involved in numerous physiological processe

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Amrahov, N. R., G. A. Aghazada, S. R. Alizada, et al. "The involvement of phytohormones in plant–pathogen interaction." Regulatory Mechanisms in Biosystems 15, no. 3 (2024): 527–42. http://dx.doi.org/10.15421/022474.

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Plant–pathogen interactions involve intricate signaling networks that coordinate the plant immune response. Recognition of pathogens through pattern recognition receptors (PRRs) triggers activation of mitogen-activated protein kinase (MAPK) pathways, initiating a cascade of defense mechanisms. Central to these responses is the synthesis of phytohormones such as salicylic acid (SA), auxins–indole-3-acetic acid (IAA), and gibberellins–gibberellic acid (GA), pivotal for immune activation. This review explores the multifaceted roles of these phytohormones in plant immunity, drawing on recent findi

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Movahedi, Ali, Soheila Aghaei-Dargiri, Bahram Barati, et al. "Plant Immunity Is Regulated by Biological, Genetic, and Epigenetic Factors." Agronomy 12, no. 11 (2022): 2790. http://dx.doi.org/10.3390/agronomy12112790.

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An immune system is a protective mechanism that shields plants from environmental stresses. This primary function is to maintain optimal circumstances for the growth and development of plant tissues while avoiding harm from biotic and abiotic stress factors. Plants subjected to various stressors initiate stress signaling cascades that affect multiple gene expressions and induce adaptation. These signaling pathways are coordinated by transcription factors, non-coding RNAs, RNA-binding proteins, and protein–protein interaction networks. Several studies have focused on various immune systems, but

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McCune, Kasi, Poornima Bhat-Nakshatri, Mangesh A. Thorat, Kenneth P. Nephew, Sunil Badve, and Harikrishna Nakshatri. "Prognosis of Hormone-Dependent Breast Cancers: Implications of the Presence of Dysfunctional Transcriptional Networks Activated by Insulin via the Immune Transcription Factor T-bet." Cancer Research 70, no. 2 (2010): 685–96. http://dx.doi.org/10.1158/0008-5472.can-09-1530.

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Chen, Ying, Shuyi Qian, Yinyin Chen, Kanghan Liu, Wei Yin, and Xun Luo. "KIAA0101 and IL2RA Were Identified as Core Genes in Hormone-Resistant Nephropathy." Disease Markers 2022 (September 17, 2022): 1–9. http://dx.doi.org/10.1155/2022/6545266.

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Objectives. To analyze the tissue heterogeneity of hormone-sensitive and drug-resistant nephrotic syndrome genes using a bioinformatics approach and to analyze gene-related functional pathways. Methods. The limma package of R software was used to screen differential genes from the nephropathy datasets GSE145969 and GSE189734. The differential genes were analyzed for functional and pathway enrichment in terms of biological processes, cellular components, and molecular functions. The Metascape tool was used to construct protein networks for the differential genes, and the results were imported i

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Wang, Yuanhua, Zhiming Yan, Weihua Tang, et al. "Impact of Chitosan, Sucrose, Glucose, and Fructose on the Postharvest Decay, Quality, Enzyme Activity, and Defense-Related Gene Expression of Strawberries." Horticulturae 7, no. 12 (2021): 518. http://dx.doi.org/10.3390/horticulturae7120518.

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Strawberry is one of the most highly consumed fruits worldwide, but is extremely perishable. This study systematically compared the effects of chitosan, sucrose, glucose, and fructose immersion on the physiology and disease development in harvested strawberries. After storage at 15 °C for 9 days, all sugar treatment groups had significantly higher total soluble solids and total anthocyanin content than those of the control group. All sugar treatment groups inhibited malondialdehyde accumulation. At the end of the storage, chitosan, glucose, and fructose maintained higher superoxide dismutase a

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Yang, Zhihui, Xiaoliu Yang, Jiahao Du, et al. "Comparative Transcriptome Analysis of Hepatopancreas Reveals Sexual Dimorphic Response to Methyl Farnesoate Injection in Litopenaeus vannamei." International Journal of Molecular Sciences 25, no. 15 (2024): 8152. http://dx.doi.org/10.3390/ijms25158152.

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Sexually dimorphic traits such as growth and body size are often found in various crustaceans. Methyl farnesoate (MF), the main active form of sesquiterpenoid hormone in crustaceans, plays vital roles in the regulation of their molting and reproduction. However, understanding on the sex differences in their hormonal regulation is limited. Here, we carried out a comprehensive investigation on sexual dimorphic responses to MF in the hepatopancreas of the most dominant aquacultural crustacean—the white-leg shrimp (Litopenaeus vannamei). Through comparative transcriptomic analysis of the main MF t

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Shankar, Kartik, Ying Zhong, Ping Kang, et al. "RNA-seq Analysis of the Functional Compartments within the Rat Placentation Site." Endocrinology 153, no. 4 (2012): 1999–2011. http://dx.doi.org/10.1210/en.2011-1833.

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The rat placentation site is distinctly organized into interacting zones, the so-called labyrinth, junctional, and metrial gland compartments. These zones house unique cell populations equipped to undertake myriad prescribed functions including transport, hormonal responses, and immune interactions. Although much is known about the genesis of these cell types and specific markers that characterize each zone, a detailed global overview of gene expression in the three zones is absent. In this report, we used massively parallel sequencing (RNA-seq) to assess mRNA expression profiles and generated

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Wu, Wei, Nilesh B. Dave, Guoying Yu, et al. "Network analysis of temporal effects of intermittent and sustained hypoxia on rat lungs." Physiological Genomics 36, no. 1 (2008): 24–34. http://dx.doi.org/10.1152/physiolgenomics.00258.2007.

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The molecular networks underlying the lung response to hypoxia are not fully understood. We employed systems biology approaches to study temporal effects of intermittent or sustained hypoxia on gene expression in rat lungs. We obtained gene expression profiles from rats exposed to intermittent or sustained hypoxia lasting 0–30 days and identified differentially expressed genes, their patterns, biological processes, and regulatory networks critical for lung response to intermittent or sustained hypoxia. We validated selected genes with quantitative real-time PCR. Intermittent and sustained hypo

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Alzahrani, Faisal A., Mohd Faheem Khan, and Varish Ahmad. "Recognition of Differentially Expressed Molecular Signatures and Pathways Associated with COVID-19 Poor Prognosis in Glioblastoma Patients." International Journal of Molecular Sciences 24, no. 4 (2023): 3562. http://dx.doi.org/10.3390/ijms24043562.

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Glioblastoma (GBM) is a type of brain cancer that is typically very aggressive and difficult to treat. Glioblastoma cases have been reported to have increased during COVID-19. The mechanisms underlying this comorbidity, including genomic interactions, tumor differentiation, immune responses, and host defense, are not completely explained. Therefore, we intended to investigate the differentially expressed shared genes and therapeutic agents which are significant for these conditions by using in silico approaches. Gene expression datasets of GSE68848, GSE169158, and GSE4290 studies were collecte

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Yu, Bo, Nian Liu, Siqi Tang, Tian Qin, and Junli Huang. "Roles of Glutamate Receptor-Like Channels (GLRs) in Plant Growth and Response to Environmental Stimuli." Plants 11, no. 24 (2022): 3450. http://dx.doi.org/10.3390/plants11243450.

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Plant glutamate receptor-like channels (GLRs) are the homologues of ionotropic glutamate receptors (iGluRs) that mediate neurotransmission in mammals, and they play important roles in various plant-specific physiological processes, such as pollen tube growth, sexual reproduction, root meristem proliferation, internode cell elongation, stomata aperture regulation, and innate immune and wound responses. Notably, these biological functions of GLRs have been mostly linked to the Ca2+-permeable channel activity as GLRs can directly channel the transmembrane flux of Ca2+, which acts as a key second

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Ametaj, Burim N. "From Parts to Whole: A Systems Biology Approach to Decoding Milk Fever." Veterinary Sciences 12, no. 4 (2025): 347. https://doi.org/10.3390/vetsci12040347.

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Milk fever, or periparturient hypocalcemia, in dairy cows has traditionally been addressed as an acute calcium deficiency, leading to interventions like supplementation and adjustments in dietary cation–anion balance. Although these measures have improved clinical outcomes, milk fever remains a widespread and economically significant issue for the dairy industry. Emerging findings demonstrate that a narrow emphasis on blood calcium concentration overlooks the complex interactions of immune, endocrine, and metabolic pathways. Inflammatory mediators and bacterial endotoxins can compromise hormon

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D’Alessio, Stefania, Stefanía Thorgeirsdóttir, Igor Kraev, Karl Skírnisson, and Sigrun Lange. "Post-Translational Protein Deimination Signatures in Plasma and Plasma EVs of Reindeer (Rangifer tarandus)." Biology 10, no. 3 (2021): 222. http://dx.doi.org/10.3390/biology10030222.

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The reindeer (caribou) Rangifer tarandus is a Cervidae in the order Artiodactyla. Reindeer are sedentary and migratory populations with circumpolar distribution in the Arctic, Northern Europe, Siberia and North America. Reindeer are an important wild and domesticated species, and have developed various adaptive strategies to extreme environments. Importantly, deer have also been identified to be putative zoonotic carriers, including for parasites, prions and coronavirus. Therefore, novel insights into immune-related markers are of considerable interest. Peptidylarginine deiminases (PADs) are a

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Khan, Shakeel Ahmad. "Network pharmacology and in silico analysis reveal Kochiae Fructus as a potential therapeutic against atopic dermatitis through immunomodulatory pathway interactions." PLOS ONE 20, no. 4 (2025): e0320818. https://doi.org/10.1371/journal.pone.0320818.

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Atopic dermatitis (AD), a chronic inflammatory disorder, poses significant therapeutic challenges owing to its complex pathophysiology, involving disrupted epidermal barrier function and immune dysregulation. This study investigated the therapeutic potential of Kochiae Fructus in AD treatment using bioinformatics, including network pharmacology and molecular docking techniques. We identified 19 key phytochemicals from Kochiae Fructus and 268 potential targets using the Traditional Chinese Medicine Systems Pharmacology Database (TCMSP) and SwissTarget Prediction. Using GeneCards, 1786 AD-relate

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Phillips, D. J., K. L. Jones, A. E. O'Connor, et al. "041.Activin A: from reproductive factor to inflammatory cytokine." Reproduction, Fertility and Development 16, no. 9 (2004): 41. http://dx.doi.org/10.1071/srb04abs041.

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Activin A was originally isolated and characterised as a reproductive feedback regulator of follicle-stimulating hormone. While potent paracrine networks involving activin and its binding protein, follistatin, are present in the gonad and pituitary, recent focus has been on emerging roles in a number of other systems, such as erythropoiesis, neuronal survival, embryonic development and inflammatory processes. The latter relatively new property was first suggested by us when follistatin in the circulation was elevated in sheep undergoing surgical trauma. We have since focussed on a model of acu

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Rudloff, Brooke, Mackenzie Stohlmann, Rachel Reith, et al. "199 Follicle Stimulating Hormone stimulation causes divergent response in Granulosa cell gene expression in typical and non-cycling heifers." Journal of Animal Science 103, Supplement_1 (2025): 24–25. https://doi.org/10.1093/jas/skaf102.027.

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Abstract Our laboratory identified 5 pubertal classifications in heifers from the UNL Research Herd: Typical, Early, Start-Stop-Start, Start-Stop-Discontinuous and Non-Cycling. Previously, we reported these heifer pubertal classifications to be moderately heritable (0.38). Non-Cycling heifers have delayed puberty characterized by reduced sexual maturity, no evidence of ovulation, and reduced numbers of calves in the first 21d of the calving season. We hypothesized that ovaries from Non-Cycling heifers were less responsive to FSH-stimulation than Typical heifers. To test this hypothesis: 1) Typ

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Wang, Jie, Huimei Fan, Mianying Li, et al. "Integration of Non-Coding RNA and mRNA Profiles Reveals the Mechanisms of Rumen Development Induced by Different Types of Diet in Calves." Genes 14, no. 5 (2023): 1093. http://dx.doi.org/10.3390/genes14051093.

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Selecting suitable feed types and understanding the gastrointestinal digestive mechanism are helpful for the growth and health of calves in intensive dairy farming. However, the effects on rumen development of changing the molecular genetic basis and the regulatory mechanism by using different feed types are still unclear. Nine 7-day-old Holstein bull calves were randomly divided into GF (concentrate), GFF (alfalfa: oat grass = 3:2) and TMR (concentrate: alfalfa grass: oat grass: water = 0.30:0.12:0.08:0.50) diet experiment groups. Rumen tissue and serum samples were collected for physiologica

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Penrose, Harrison Michael, Hani Nakhoul, Nathan Ungerleider, Erik Flemington, and Suzana Savkovic. "3253 Identification of Immune Cell Profiles and Molecular Pathways in Inflammatory Bowel Disease Driving Non-Response to Biologic Therapy." Journal of Clinical and Translational Science 3, s1 (2019): 13–14. http://dx.doi.org/10.1017/cts.2019.35.

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OBJECTIVES/SPECIFIC AIMS: Inflammatory Bowel Disease (IBD) is a chronic, life-long condition characterized by inflammation of the intestine that greatly affects an individual’s quality of life. While biologic therapy directed against TNFα (anti-TNFα, Infliximab) and α4β7 integrin (anti-α4β7; Vedolizumab) is used to treat IBD, a substantial number of patients remain non-responsive. Using a comprehensive bioinformatics approach, the aim of this study was to characterize immune cell profiles and altered molecular pathways in IBD patient non-responders to anti-TNFα and anti-α4β7 therapy to determi

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Mercer, Audrey, Marco Sancandi, Amy Maclatchy, and Sigrun Lange. "Brain-Region-Specific Differences in Protein Citrullination/Deimination in a Pre-Motor Parkinson’s Disease Rat Model." International Journal of Molecular Sciences 25, no. 20 (2024): 11168. http://dx.doi.org/10.3390/ijms252011168.

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The detection of early molecular mechanisms and potential biomarkers in Parkinson’s disease (PD) remains a challenge. Recent research has pointed to novel roles for post-translational citrullination/deimination caused by peptidylarginine deiminases (PADs), a family of calcium-activated enzymes, in the early stages of the disease. The current study assessed brain-region-specific citrullinated protein targets and their associated protein–protein interaction networks alongside PAD isozymes in the 6-hydroxydopamine (6-OHDA) induced rat model of pre-motor PD. Six brain regions (cortex, hippocampus,

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Elanany, Mona M., Dina Mostafa, Ahmad A. Hady, et al. "CCR4-NOT Transcription Complex Subunit 7 (CNOT7) Protein and Leukocyte-Associated Immunoglobulin-like Receptor-1 in Breast Cancer Progression: Clinical Mechanistic Insights and In Silico Therapeutic Potential." International Journal of Molecular Sciences 26, no. 15 (2025): 7141. https://doi.org/10.3390/ijms26157141.

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Metastatic breast cancer (BC) spread underscores the need for novel prognostic biomarkers. This study investigated CCR4-NOT Transcription Complex Subunit 7 (CNOT7) and leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) in BC progression and natural killer (NK) cell resistance. In the current study, 90 female BC patients (46 non-metastatic, 44 metastatic) were analyzed. CNOT7 and LAIR-1 protein levels were measured in serum via ELISA and CNOT7 expression in tissue by immunohistochemistry (IHC). In silico tools explored related pathways. Computational analyses, including in silico bioi

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MARCHETTI, BIANCA, FRANCESCO GALLO, ZELINDA FARINELLA, CARMELA ROMEO, and MARIA C. MORALE. "Luteinizing Hormone-Releasing Hormone (LHRH) Receptors in the Neuroendocrine-Immune Network." Annals of the New York Academy of Sciences 784, no. 1 Challenges an (1996): 209–36. http://dx.doi.org/10.1111/j.1749-6632.1996.tb16238.x.

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Dongre, Anushka. "Abstract B022: Targeting epithelial-mesenchymal plasticity and CD73 to enhance responses of breast cancers to immune checkpoint blockade therapies." Cancer Research 84, no. 3_Supplement_1 (2024): B022. http://dx.doi.org/10.1158/1538-7445.advbc23-b022.

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Abstract Immune checkpoint blockade (ICB) therapy has generated dramatic responses in certain types of human tumors however, the response of breast cancers has been largely limited. Epithelial-mesenchymal plasticity (EMP) enables carcinoma cells to metastasize, gain tumor-initiating ability and mount resistance to chemotherapies. In addition, we have demonstrated that this plasticity program also contributes to the establishment of an immunosuppressive tumor microenvironment and confers resistance to ICB therapy (Dongre and Weinberg 2019). By establishing novel, preclinical models of more-epit

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Perov, Sergey Yu, Larisa V. Pokhodzey, Yuriy P. Paltsev, and Rano Z. Lifanova. "2–5 G mobile communication electromagnetic field chronic animal exposure assessment." Hygiene and sanitation 104, no. 3 (2025): 258–64. https://doi.org/10.47470/0016-9900-2025-104-3-258-264.

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Introduction. The intensive implementation of modern wireless communications networks using multi-frequency modulated electromagnetic fields radiofrequency (EMF RF) has led to a significant change in the electromagnetic background, which requires scientific research to assess the human health risk. The aim of the study. To study the features of the biological effects chronic exposure to multi-frequency EMF RF from mobile communication systems of GSM (2G), UMTS (3G), LTE (4G) and 5G NR IMT-2020 (5G) standards on some state of indices in animals. Materials and methods. Male Wistar rats of 180–20

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Mesrizadeh, Zahra, Kavitha Mukund, Fokrul Hossain, et al. "Abstract LB006: Cell marker-based classification of TNBC subtypes and patient outcomes." Cancer Research 84, no. 7_Supplement (2024): LB006. http://dx.doi.org/10.1158/1538-7445.am2024-lb006.

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Abstract Background: Triple-negative breast cancer (TNBC) is an aggressive BC subtype characterized by significant molecular and clinical heterogeneity, influenced by genetic, phenotypic, and environmental factors, as well as interactions of the tumor with its surrounding milieu. In the recent past, gene expression-based subtyping methods have provided a functional understanding for the observed molecular diversity/heterogeneity. In this study, we propose an approach to reclassifying TNBC while considering the cellular heterogeneity of the tumor as well as the tumor milieu. Methods: RNA-Sequen

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Harrison, Leonard C., and Iain L. Campbell. "MINIREVIEW: Cytokines: An Expanding Network of Immuno-lnflammatory Hormones." Molecular Endocrinology 2, no. 12 (1988): 1151–56. http://dx.doi.org/10.1210/mend-2-12-1151.

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Wang, Dan, Mingyue Li, Jing Li, et al. "Comprehensive Characterization of Androgen-Responsive lncRNAs Mediated Regulatory Network in Hormone-Related Cancers." Disease Markers 2020 (September 26, 2020): 1–18. http://dx.doi.org/10.1155/2020/8884450.

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The AR signaling pathway plays an important role in initiation and progression of many hormone-related cancers including prostate, bladder, kidney, lung, and breast cancer. However, the potential roles of androgen-responsive long noncoding RNAs (lncRNAs) in hormone-related cancers remained unclear. In the present study, we identified 469 novel androgen-responsive lncRNAs using microarray data. After validating the accuracy of the array data, we constructed a transcriptional network which contained more than 30 transcriptional factors using ChIP-seq data to explore upstream regulators of androg

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Spiga, Francesca, Eder Zavala, Jamie J. Walker, Zidong Zhao, John R. Terry, and Stafford L. Lightman. "Dynamic responses of the adrenal steroidogenic regulatory network." Proceedings of the National Academy of Sciences 114, no. 31 (2017): E6466—E6474. http://dx.doi.org/10.1073/pnas.1703779114.

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The hypothalamic–pituitary–adrenal axis is a dynamic system regulating glucocorticoid hormone synthesis in the adrenal glands. Many key factors within the adrenal steroidogenic pathway have been identified and studied, but little is known about how these factors function collectively as a dynamic network of interacting components. To investigate this, we developed a mathematical model of the adrenal steroidogenic regulatory network that accounts for key regulatory processes occurring at different timescales. We used our model to predict the time evolution of steroidogenesis in response to phys

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CSABA, G., P. KOVACS, and E. PALLINGER. "In vitro effect of biogenic amines on the hormone content of immune cells of the peritoneal fluid and thymus. Is there a hormonal network inside the immune system?" Cell Biology International 31, no. 3 (2007): 224–28. http://dx.doi.org/10.1016/j.cellbi.2006.10.007.

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Liu, Qianqian, Xiaoli Tang, Haipeng Xu, Jie Wen, Yangyang Chen, and Shoubin Xue. "Weighted gene co-expression network analysis reveals key biomarkers and immune infiltration characteristics for bronchial epithelial cells from asthmatic patients." Medicine 103, no. 16 (2024): e37796. http://dx.doi.org/10.1097/md.0000000000037796.

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Background: Asthma ranks among the most prevalent non-communicable diseases worldwide. Previous studies have elucidated the significant role of the immune system in its pathophysiology. Nevertheless, the immune-related mechanisms underlying asthma are complex and still inadequately understood. Thus, our objective was to investigate novel key biomarkers and immune infiltration characteristics associated with asthma by employing integrated bioinformatics tools. Methods: In this study, we conducted a weighted gene co-expression network analysis (WGCNA) to identify key modules and genes potentiall

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Csaba, G., and É. Pállinger. "In vitro effect of hormones on the hormone content of rat peritoneal and thymic cells. Is there an endocrine network inside the immune system?" Inflammation Research 56, no. 11 (2007): 447–51. http://dx.doi.org/10.1007/s00011-007-7021-6.

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Cui, Jingwen, Wanrong Song, Yipeng Jin, et al. "Research Progress on the Mechanism of the Acupuncture Regulating Neuro-Endocrine-Immune Network System." Veterinary Sciences 8, no. 8 (2021): 149. http://dx.doi.org/10.3390/vetsci8080149.

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As one of the conventional treatment methods, acupuncture is an indispensable component of Traditional Chinese Medicine. Currently, acupuncture has been partly accepted throughout the world, but the mechanism of acupuncture is still unclear. Since the theory of the neuro-endocrine-immune network was put forward, new insights have been brought into the understanding of the mechanism of acupuncture. Studies have proven that acupuncture is a mechanical stimulus that can activate local cell functions and neuroreceptors. It also regulates the release of related biomolecules (peptide hormones, lipid

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Krebs, S., S. Bauersachs, H. D. Reichenbach, et al. "175 TRANSCRIPTOME ANALYSIS OF BOVINE DAY 150 FETAL LIVER AND COTYLEDON REVEALS GENES INVOLVED IN FETAL GROWTH." Reproduction, Fertility and Development 20, no. 1 (2008): 167. http://dx.doi.org/10.1071/rdv20n1ab175.

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Major problems in breeding of modern dairy cows include increasing rates of stillbirth and dystocia, associated with elevated costs for veterinary intervention (caesarean section) and loss of production animals (cows and calves). Rates of stillbirth as high as 12% have been reported, primarily caused by fetal overgrowth and increased birth weight. In order to discover molecular markers for selection against stillbirth, we developed a model for the inheritance of fetal growth traits. A Fleckvieh bull segregating for paternal stillbirth was used for insemination of 36 cows that were slaughtered

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Jiang, Shengyuan, Yixiao Wang, Haiyan Chen, Yuanyuan Teng, Qiaoying Zhu, and Kaipeng Xie. "Exploring the Role of Bifenthrin in Recurrent Implantation Failure and Pregnancy Loss Through Network Toxicology and Molecular Docking." Toxics 13, no. 6 (2025): 454. https://doi.org/10.3390/toxics13060454.

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Bifenthrin (BF) is a widely used pyrethroid pesticide recognized as an endocrine-disrupting chemical (EDC). Previous studies have confirmed that chronic exposure to BF is associated with various health risks. However, its potential association with recurrent implantation failure (RIF) and recurrent pregnancy loss (RPL) remains unclear. In this study, the potential targets of BF were identified using several databases, including the Comparative Toxicogenomics Database (CTD), TargetNet, GeneCards, SwissTargetPrediction, and STITCH. Differentially expressed genes (DEGs) associated with RIF were o

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