Academic literature on the topic 'HPLC method development'

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Journal articles on the topic "HPLC method development"

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Snyder, Lloyd R., Joseph L. Glajch, Joseph J. Kirkland, and Richard W. Abbott. "Practical HPLC method development." Analytica Chimica Acta 245 (1991): 287–88. http://dx.doi.org/10.1016/s0003-2670(00)80235-4.

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Krull, L. S. "Practical HPLC Method Development." TrAC Trends in Analytical Chemistry 8, no. 9 (1989): 349–50. http://dx.doi.org/10.1016/0165-9936(89)87046-3.

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Schoenmakers, Peter. "Practical HPLC method development." Journal of Chromatography A 509, no. 2 (1990): 406–7. http://dx.doi.org/10.1016/s0021-9673(01)93100-0.

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Kennedy, John F., and Maria da Paz C. Silva. "Practical HPLC method development." Carbohydrate Polymers 16, no. 3 (1991): 338. http://dx.doi.org/10.1016/0144-8617(91)90119-w.

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Akash, Shelake* Mrs. Jaya D. kamble Dr. Nilesh Chougule. "HPLC Development Method and Validation." International Journal of Pharmaceutical Sciences 2, no. 11 (2024): 910–19. https://doi.org/10.5281/zenodo.14203300.

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Chromatography, while primarily a separation technique, is widely used in chemical analysis. High-performance liquid chromatography (HPLC) is a highly versatile technology that separates analytes by passing them through a column filled with micrometer-sized particles. Today, reversed-phase chromatography is the most extensively utilized separation technique in HPLC. This is due to the reversed-phase method's simplicity, versatility, and scope, which can handle compounds with a wide range of polarity and molecular mass.This article discusses tactics and difficulties for planning HPLC method dev
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Nikita, Pabale* Monali Khatke Mansi Shelke Vishweshwari Bhagat Tanvi Kamble. "A Review on HPLC Method Development and Validation." International Journal of Pharmaceutical Sciences, no. 11 (November 28, 2024): 1496–509. https://doi.org/10.5281/zenodo.14234238.

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High-Performance liquid chromatography (HPLC) is widely recognized as the most commonly used separation technique for the detection, separation, and quantification of drugs. To optimize HPLC methods, various chromatographic parameters are evaluated, including sample pretreatment, choice of mobile phase, column selection, and detector type. This article aims to discuss the processes involved in method development, optimization, and validation. The development and validation of analytical methods are critical in the discovery, development, and manufacturing of pharmaceutical drugs, as well as in
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Jinal, Harshadkumar Rathod *. Jaymin G. Patel Bhumi R. Patel. "ESTIMATION OF CLOTRIMAZOLE, CLINDAMYCIN PHOSPHATE AND TINIDAZOLE BY VARIOUS ANALYTICAL METHOD: REVIEW ARTICLE." Journal of Pharma Research 8, no. 4 (2019): 160–68. https://doi.org/10.5281/zenodo.2647870.

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<strong><em>ABSTRACT</em></strong> <strong><em>A</em></strong><em>nalytical method development and its validation is an important aspect in drug discovery process. Development of analytical method producing accurate and precise data is necessary to ensure the quality and safety of the drugs. At present, the most common analytical method employed for estimation of drugs is Reverse Phase High Pressure Liquid Chromatography (RP-HPLC) because of its high sensitivity, accuracy and speed. Different types of analytical methods are available for estimation of Clindamycin Phosphate, Clotrimazole and Ti
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Strasters, J. K. "Computerized method development for HPLC." TrAC Trends in Analytical Chemistry 10, no. 3 (1991): x—xi. http://dx.doi.org/10.1016/0165-9936(91)85084-5.

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K., Nagaraju, Mekala Sunil, Anusha M., Gopaiah Kurra Venkata, and Subbarao G. "Carvedilol, Tablets Assay Method Development and Validation by UV Spectroscopy, RP-HPLC and HPTLC." Trends in Pharmaceuticals and Nanotechnology (e-ISSN: 2582-4457) 2, no. 1 (2020): 37–47. https://doi.org/10.5281/zenodo.3632225.

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<em>Aim &amp; Objectives : </em><em>The present study describes the development of a new rapid, simple, sensitive and reproducible RP-HPLC, HPTLC, UV Spectrophotometry method for the analysis of Carvedilol that offer certain advantages in its simplicity and sensitivity and applicable in routine analysis. Material &amp; Methods: Carvedilol is polar in nature, reverse phase chromatography has been used and assay method is developed for UV-Spectroscopy, RP-HPLC, &amp; HPTLC&nbsp;&nbsp; &amp; method validation is also done. Results &amp; Discussion: The validated method was applied for the analysi
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Amandeep, Kaur*and Monika Gupta. "DEVELOPMENT AND VALIDATION OF METHOD BY HPLC TECHNIQUES." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 07 (2018): 7057–65. https://doi.org/10.5281/zenodo.1325897.

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<em>The primary focus of the review article is on general approaches and considerations toward development of chromatographic methods for separation, identification, and quantification of compounds, which may be applied within the various functions in the drug development continuum. This article also discusses the issues and parameters that must be considered in the validation of analytical methods. At the end of the review, a scope of the present research study is covered.</em> <strong>Keywords: </strong><em>Introduction, Method development, Steps for HPLC method development, Method validatio
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Dissertations / Theses on the topic "HPLC method development"

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Wintergerst, Mieke. "Detection of inositol phosphates with HPLC-ICP-AES : Method development." Thesis, Uppsala universitet, Analytisk kemi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-202003.

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Inositol phosphates (IPs) represent a major part of the organic phosphorus found in the environment, which makes their identification and quantification very important. The goal of this project was to explore the possibility of quantification of IPs with inductively coupled plasma - atomic emission spectrometry (ICP - AES). This paper deals with the creation of an in-house IP standard and the considerations for the successful linking of high performance liquid chromatography (HPLC) with ICP - AES. Experiments with different nebulizers, mobile phases, standard solutions and model substance were
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Pretorius, Marguerite. "PheroidTM-based anti-malarial formulations : HPLC method development and stability studies." Thesis, North-West University, 2008. http://hdl.handle.net/10394/4180.

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Malaria remains one on the world's most common infectious diseases with 300 to 500 million cases every year. The current treatment of malaria is restricted due to ever increasing drug resistance, cost of treatment and the availability of treatment. When looking at solutions for these problems, new drug delivery systems should be taken into consideration. The Pheroid™ drug delivery system which incorporates Pheroid™ technology can be placed in this category and the stability of anti-malarial drugs in combination with the Pheroid™ drug delivery system was investigated. The main objectives of thi
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Ganti, Satyakala. "DEVELOPMENT OF HPLC METHODS FOR PHARMACEUTICALLY RELEVANT MOLECULES; METHOD TRANSFER TO UPLC: COMPARING METHODS STATISTICALLY FOR EQUIVALENCE." Diss., Temple University Libraries, 2011. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/118587.

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Chemistry<br>Ph.D.<br>High Pressure Liquid Chromatography (HPLC) is a well-known and widely used analytical technique which is prevalent throughout the pharmaceutical industry as a research tool. Despite its prominence HPLC possesses some disadvantages, most notably slow analysis time and large consumption of organic solvents. Ultra Pressure Liquid Chromatography (UPLC) is a relatively new technique which offers the same separation capabilities of HPLC with the added benefits of reduced run time and lower solvent consumption. One of the key developments which facilitate the new UPLC technology
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Undin, Torgny. "Development and improvement of methods for characterization of HPLC stationary phases." Licentiate thesis, Uppsala universitet, Analytisk kemi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-166978.

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High Performance Liquid Chromatography (HPLC) is a widely used tech-nique both for detecting and purifying substances in academy and in the industry. In order to facilitate the use of, and knowledge in HPLC, character-ization of stationary phases is of utmost importance. Tailor made characteri-zation methods and workflows are steadily increasing the speed and accura-cy in which new separation systems and methods are developed. In the field fundamental separation science and of preparative chromatography there is always the need for faster and more accurate methods of adsorption isotherm determ
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Andersson, Anja. "Method development for the determination of thiols using HPLC with fluorescence detection." Thesis, Umeå universitet, Kemiska institutionen, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-59827.

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Zhong, Fanyi. "DEVELOPMENT AND APPLICATIONS OF HPLC-MS/MS BASED METABOLOMICS." Miami University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=miami1524792637748877.

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Kühn, Antoinette. "Pro-Pheroid-based antiretroviral formulations : HPLC method development and stability studies / Antoinette Kühn." Thesis, North-West University, 2008. http://hdl.handle.net/10394/2320.

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Oteef, Mohammed Dhafer Y. "Analysis of the potato sprout inhibitor 1, 4-dimethylnapthalene : HPLC method development and applications." Thesis, University of Glasgow, 2008. http://theses.gla.ac.uk/319/.

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1,4-Dimethylnaphthalene (1,4-DMN) is a pesticide used for inhibiting the sprouting of stored potatoes, and therefore prolonging the storage time. It is registered for commercial use in different parts of the world (e.g. USA and New Zealand) and its registration process in the EU is at an advanced stage. Limited information is available regarding the behaviour and fate of this pesticide in the environment, and therefore, various studies are required in this field. In such studies, analytical methods for the determination of 1,4-DMN in the different environmental samples are a core element. This
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Schmidt, Alexander H. [Verfasser]. "Innovative HPLC Method Design (Development & Understanding) within the Pharmaceutical Lifecycle / Alexander H. Schmidt." Berlin : Freie Universität Berlin, 2018. http://d-nb.info/1150238100/34.

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Lindholm, Johan. "Development and Validation of HPLC Methods for Analytical and Preparative Purposes." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4442.

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Books on the topic "HPLC method development"

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Snyder, Lloyd R., Joseph J. Kirkland, and Joseph L. Glajch. Practical HPLC Method Development. John Wiley & Sons, Inc., 1997. http://dx.doi.org/10.1002/9781118592014.

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1925-, Kirkland J. J., and Glajch Joseph L, eds. Practical HPLC method development. 2nd ed. Wiley, 1997.

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L, Glajch Joseph, and Kirkland J. J. 1925-, eds. Practical HPLC method development. J. Wiley, 1988.

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Corradini, Fabio. Development of a HPLC method for analysis of DMSP, glycinebetaine and proline in plants. University College Dublin, 1996.

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Gill, Sukwinder Kaur. Development of a method for the determination of chlortetracycline (CTC) in a three component mixture (Microfac) by HPLC. University of Wolverhampton, 1997.

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Samanidou, Victoria. Drug monitoring by HPLC: Recent developments. Nova Science, 2010.

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Christine T. C. Fook Sheung. The applicability of ASTED/HPLC to the development of bioanalytical methods. De Montfort University, 1996.

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Snyder, Lloyd R., Joseph J. Kirkland, and Joseph L. Glajch. Practical HPLC Method Development. Wiley & Sons, Incorporated, John, 2010.

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Snyder. Practical HPLC Method Development. Wiley & Sons, Incorporated, John, 1998.

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Snyder, Lloyd R. Practical HPLC Method Development. Wiley India, 2011.

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Book chapters on the topic "HPLC method development"

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LoBrutto, Rosario. "Method Development." In HPLC for Pharmaceutical Scientists. John Wiley & Sons, Inc., 2006. http://dx.doi.org/10.1002/9780470087954.ch8.

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Machtejevas, Egidijus. "Additional Tools for Method Development: Flow and Temperature Gradients." In Gradient HPLC for Practitioners. Wiley-VCH Verlag GmbH & Co. KGaA, 2019. http://dx.doi.org/10.1002/9783527812745.ch9.

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Ahuja, Satinder. "Basic Considerations in HPLC Method Development of Chiral Compounds." In Chiral Separation Methods for Pharmaceutical and Biotechnological Products. John Wiley & Sons, Inc., 2010. http://dx.doi.org/10.1002/9780470608661.ch3.

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Roja, Aavula, Peram Uma Maheshwari, Ramapuram Munemma, and Konda Swathi. "Method Development and Validation of Gallic Acid in Liquid Dosage Form by Using RP-HPLC Method." In Advances in Experimental Medicine and Biology. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-31986-0_51.

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Guo, Xuewu, Lina Li, Yefu Chen, and Dongguang Xiao. "Development of HPLC Method for Determination of the Content of Tyramine in Rice Wine." In Proceedings of the 2012 International Conference on Applied Biotechnology (ICAB 2012). Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-37916-1_57.

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Ates, Hasret, Debby Mangelings, and Yvan Vander Heyden. "High-Throughput Screening and Method Development Strategies to Separate Chiral Drug Compounds in HPLC, SFC, and CE." In Chiral Separation Methods for Pharmaceutical and Biotechnological Products. John Wiley & Sons, Inc., 2010. http://dx.doi.org/10.1002/9780470608661.ch12.

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"HPLC Method Development." In Modern HPLC for Practicing Scientists. John Wiley & Sons, Inc., 2006. http://dx.doi.org/10.1002/0471973106.ch8.

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Rasmussen, Henrik T., Weiyong Li, Dirk Redlich, and M. Ilias Jimidar. "6 HPLC method development." In Separation Science and Technology. Elsevier, 2005. http://dx.doi.org/10.1016/s0149-6395(05)80050-9.

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"Preparative HPLC Separation." In Practical HPLC Method Development. John Wiley & Sons, Inc., 2012. http://dx.doi.org/10.1002/9781118592014.ch13.

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"Computer-Assisted Method Development." In Practical HPLC Method Development. John Wiley & Sons, Inc., 2012. http://dx.doi.org/10.1002/9781118592014.ch10.

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Conference papers on the topic "HPLC method development"

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Chia, Dian Ning, Fanyi Duanmu, Luca Mazzei, Eva Sorensen, and Maximilian O. Besenhard. "The Smart HPLC Robot: Fully Autonomous Method Development Guided by A Mechanistic Model Framework." In The 35th European Symposium on Computer Aided Process Engineering. PSE Press, 2025. https://doi.org/10.69997/sct.116643.

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Developing ultra- or high-performance liquid chromatography (HPLC) methods for analysis or purification requires significant amounts of material and manpower, and typically involves time-consuming iterative lab-based workflows. This work demonstrates in two case studies that an autonomous HPLC platform coupled with a mechanistic model that self-corrects itself by performing parameter estimation can efficiently develop an optimized HPLC method with minimal experiments (i.e., reduced experimental costs and burden) and manual intervention (i.e., reduced manpower). At the same time, this HPLC plat
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Devina, Kezia Elian, Dono Indarto, and Tri Nugraha Susilawati. "Identification of Quercetin and Chrysin in Banana Peel Extract Using High Performance Liquid Chromatography and Liquid Chromatography Mass Spectrometer for Obesity Treatment." In 8th International Conference on Advanced Material for Better Future. Trans Tech Publications Ltd, 2025. https://doi.org/10.4028/p-6iz2xi.

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Pancreatic lipase plays an important role in converting triglyceride into long-chain fatty acids and glycerol, then becomes a therapeutic target for obesity treatment. Quercetin and chrysin are able to inhibit pancreatic lipase, which is potentially developed for obesity treatment. This study aimed to identify quercetin and chrysin derived from the methanol extract of raja and kepok banana peels using High Performance Liquid Chromatography (HPLC) and Liquid Chromatography Mass Spectrometer (LC-MS) for the development of obesity treatment. Raja and kepok banana peels were purchased from a fruit
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Sanchez, Joseph, Chuan Zhang, John Aguada, Jane Li, Jiaqi Tang, and Chris Richardson. "Advanced Package Sample Preparation Leveraging Precision CNC-Based Milling and Selective Microwave Induced Plasma Etching." In ISTFA 2024. ASM International, 2024. http://dx.doi.org/10.31399/asm.cp.istfa2024p0492.

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Abstract The rapid development of advanced packaging technologies for high-performance computing (HPC) applications poses significant challenges for sample preparation methodologies. Conventional techniques are often insufficient to cope with the complex architectures and heterogeneous materials of modern packages, such as COWOS (Chip-on-Wafer-on-Substrate) and 3D structures. In this paper, we present a novel approach for sample preparation that leverages precision CNC (Computer Numerical Control) milling and selective MIP plasma etch. These methods enable precise and selective removal of unwa
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Chen, Tao, Ping Chen, Harry Montgomerie, Thomas Hagen, and Henry Ekpeni. "Development of Environmentally Friendly Calcium Carbonate Scale Inhibitor for HTHP Squeeze Application in the Oil and Gas Field Water Treatment." In CORROSION 2011. NACE International, 2011. https://doi.org/10.5006/c2011-11389.

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Abstract The formation of calcium carbonate mineral scale is a persistent and expensive problem in oil and gas production, especially in the high temperature and high pressure (HTHP) wells. Scaling of metallic or insulating walls in contact with hard water may cause unscheduled equipment shutdown and loss of production. The aim of this paper is to develop environmentally friendly calcium carbonate scale inhibitors for HTHP squeeze application in the oil and gas field water treatment. Typical commercial scale inhibitors, including several phosphonate based squeeze scale inhibitors and patented
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Hoang, Nhung. "Development of method for determination of diacerein in raw material by HPLC." In MOL2NET'22, Conference on Molecular, Biomedical & Computational Sciences and Engineering, 8th ed. - MOL2NET: FROM MOLECULES TO NETWORKS. MDPI, 2022. http://dx.doi.org/10.3390/mol2net-08-12784.

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Kumar, Praveen, Meenu Chaudhary, Vaibhav Rathi, Bhupendra Singh, Manish Vyas, and Geetanjali Saini. "Validated analytical method development for drug residue (Clonazepam) in pharmaceutical industries by RP-HPLC." In THE FOURTH SCIENTIFIC CONFERENCE FOR ELECTRICAL ENGINEERING TECHNIQUES RESEARCH (EETR2022). AIP Publishing, 2023. http://dx.doi.org/10.1063/5.0162987.

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Logoyda, Liliya, and Kateryna Typlynska. "Development of the HPLC method for the determination of related substances in ramipril tablets." In MOL2NET'22, Conference on Molecular, Biomedical & Computational Sciences and Engineering, 8th ed. - MOL2NET: FROM MOLECULES TO NETWORKS. MDPI, 2022. http://dx.doi.org/10.3390/mol2net-08-13919.

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Wei, Na, Enada Archibold, Grace Jairo, and Heather Kuiper. "Development of a method for separation of geometric isomers of alpha-linolenic acid in human plasma by silver Ion HPLC and GC-NCI-MS." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/fvyw5862.

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Alpha-linolenic acid (ALA), an omega-3 fatty acid essential for humans, must be supplied by diet, mainly from plants. It's a precursor of omega-3 long-chain fatty acids, eicosapentaenoic and docosahexaenoic acids which are essential for human cardiovascular health. ALA consumption may also reduce the risk of heart disease. The geometric isomers of ALA in humans are derived from consumption of industrially produced partially hydrogenated and deodorized vegetable oils. The presence of trans-isomers of ALA in humans may affect the levels of regular ALA, potentially impacting the beneficial effect
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Pysz, Ilona, Paul J. Jackson, Khondaker M. Rahman, and David E. Thurston. "Abstract 738: Development of an HPLC method for the assessment of hydrophobicity of ADC payloads." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-738.

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Al-Samarrai, Saif Dahham Hameedi, and Eman Thiab Al-Samarraie. "Development and validation of RP-HPLC method analysis for COVID-19 antiviral drug Samavir tablet." In 1ST SAMARRA INTERNATIONAL CONFERENCE FOR PURE AND APPLIED SCIENCES (SICPS2021): SICPS2021. AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0120911.

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Reports on the topic "HPLC method development"

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Joyce, Christine, and Deidre Mountain. Optimization of Liposomal Encapsulation Efficiency. University of Tennessee Health Science Center, 2021. http://dx.doi.org/10.21007/com.lsp.2018.0002.

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Introduction: My project was a continuation of the Vascular Research Lab’s (VRL) ongoing research at the University of Tennessee Medical Center Knoxville (UTMCK) aimed at optimizing liposomal encapsulation efficiency of small interfering RNA (siRNA) which can be used to silence genes to prevent a variety of disease pathologies. Methods: Assay siRNA loading capacity of liposomes based on lipid concentration Development of a method for liposome purification: HPLC &amp; HiTRAP Column Results &amp; Conclusion: siRNA loading capacity Higher lipid:siRNA resulted in increased encapsulation efficiency
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หนูจักร, ธรรมนูญ, та อมร เพชรสม. การพัฒนาวิธีการวิเคราะห์และการหาปริมาณแคปไซซินและไดไฮโดรแคปไซซิน ในผลิตภัณฑ์พริกและอาหารรสเผ็ด : รายงานการวิจัยฉบับสมบูรณ์ ปีที่ 3 (ต.ค. 2551 ถึง ก.ย. 2552) ( Development of analytical methods and determination of capsaicin and dihydrocapsaicin in chili products and hot spicy food). จุฬาลงกรณ์มหาวิทยาลัย, 2009. http://dx.doi.org/10.58837/chula.res.2009.1.

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ได้ประยุกต์วิธีการเตรียมตัวอย่างและเทคนิคไมเซลลาร์อิเล็กโทรไคเนทิกโครมาโทกราฟี (MEKC) ที่พัฒนาขึ้นในงานวิจัยก่อนหน้านี้ สำหรับการวิเคราะห์ปริมาณแคปไซซินอยด์ (CAPs) ในตัวอย่างจริงที่เป็นซอสพริกและเครื่องแกงสำเร็จรูป เมื่อใช้การทดสอบทางสถิติด้วยวิธี paired t-test ที่ระดับความเชื่อมั่น 95 % พบว่าปริมาณของ CAPs ในซอสพริก 9 ตัวอย่างที่วิเคราะห์ได้ด้วยเทคนิค MEKC และ HPLC ไม่มีความแตกต่างอย่างมีนัยสำคัญ จากการวิเคราะห์ด้วย MEKC ปริมาณ CAPs ที่พบในซอสพริก 22 ตัวอย่าง อยู่ในช่วง 13 ถึง 262 ppm และปริมาณ CAPs ในเครื่องแกงสำเร็จรูป 5 ตัวอย่าง อยู่ในช่วง 41 ถึง 140 ppm โดยที่ซอสพริก 7 ตัวอย่าง และเครื่อง
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Pasupuleti, Murali Krishna. Mathematical Modeling for Machine Learning: Theory, Simulation, and Scientific Computing. National Education Services, 2025. https://doi.org/10.62311/nesx/rriv125.

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Abstract Mathematical modeling serves as a fundamental framework for advancing machine learning (ML) and artificial intelligence (AI) by integrating theoretical, computational, and simulation-based approaches. This research explores how numerical optimization, differential equations, variational inference, and scientific computing contribute to the development of scalable, interpretable, and efficient AI systems. Key topics include convex and non-convex optimization, physics-informed machine learning (PIML), partial differential equation (PDE)-constrained AI, and Bayesian modeling for uncertai
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