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Journal articles on the topic 'HSV system'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

P, Das. "Semen Infection Associated Male Infertility and Role of Assisted Reproductive Techniques: A Review." Virology & Immunology Journal 6, no. 3 (2022): 1–9. http://dx.doi.org/10.23880/vij-16000297.

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Recent research has revealed that pathogens in the semen and in the genital tract play a significant role in male infertility. The infection of viruses like Human Immunodeficiency Virus (HIV), Hepatitis B virus (HBV), Hepatitis C virus (HCV), Human Papilloma Virus (HPV), Herpes-Simplex Virus (HSV), and Human Cytomegalovirus (HCMV) may have a significant impact on male infertility. These infections may lead to temporary or permanent infertility, hormonal impairment, testicular malfunction, or abnormal spermatogenesis. This review is looking into the mechanism of viral infections and their effec

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Higashimoto, Yuki, Soichiro Ishimaru, Hiroki Miura, et al. "1417. Detection of Human Herpesviruses DNA in Cerebrospinal Fluids of Patients Suspected with Central Nervous System Infection." Open Forum Infectious Diseases 6, Supplement_2 (2019): S516. http://dx.doi.org/10.1093/ofid/ofz360.1281.

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Abstract Background Of the nine human herpesviruses (HHVs), most viruses have neurovirulence. Clinical manifestations of central nervous system (CNS) complications caused by some of the HHVs are well examined in children and immunocompromised adults; however, information of EBV and β-herpesviruses in an immunocompetent adult is limited. Methods Between April 2013 and March 2018, 322 patients (median age; 51.6 years old, male/female; 196/126) suspected to CNS infection were enrolled in this study. Patients with unconsciousness or characteristic change lasting more than 24 hours and abnormal bra

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Bermawi, Bastiana, Endang Retnowati K, and Erwin A. Triyono. "PERHITUNGAN JUMLAH SEL CD4 DENGAN SEROPOSITIF IgM HERPES SIMPLEKS TIPE-2 DI PASIEN HIV." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 15, no. 3 (2018): 73. http://dx.doi.org/10.24293/ijcpml.v15i3.970.

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Herpes simplex type-2 (HSV-2) infection is usually transmitted sexually and can cause recurrent, painful genital ulcers. Seropositivityof IgM HSV-2 indicates acute infection of HSV-2. The low level of CD4 cell counts can lead to opportunistic infection in HIV patients.Therefore, the aim of this study is to investigate the association between CD4 cell counts and HSV-2 infection (based on seropositivity ofIgM HSV-2) in HIV patients with heterosexual risk factor in Dr. Soetomo Hospital, Surabaya. Specimens were collected during the firstpresentation on June and July 2008. HSV-2 IgM and was assess

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Tsitoura, Eliza, Michaela Lucas, Valerie Revol-Guyot, Alberto L. Epstein, Roberto Manservigi, and Penelope Mavromara. "Expression of hepatitis C virus envelope glycoproteins by herpes simplex virus type 1-based amplicon vectors." Journal of General Virology 83, no. 3 (2002): 561–66. http://dx.doi.org/10.1099/0022-1317-83-3-561.

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Herpes simplex virus type 1 (HSV-1)-based amplicon vectors expressing hepatitis C virus (HCV) E1 and E2 glycoproteins were investigated. HSV-1 amplicon vectors carrying the E1E2p7- or E2p7-coding sequences of HCV type 1a under the control of the HSV-1 IE4 (α22/α47) promoter were constructed. Studies of infected HepG2, WRL 68 or Vero cells indicated that HSV-1-based amplicon vectors express high levels of HCV glycoproteins that are processed correctly. Immunofluorescence microscopy combined with immunoprecipitation and endoglycosidase treatment of cells infected with the HSV-1-based vectors exp

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Malolina, E. A., A. L. Lebedeva, A. Yu Kulibin, et al. "Interaction of herpesviruses with mature human spermatozoa in the model system <i>in vitro</i>." Problems of Virology 61, no. 3 (2016): 119–25. http://dx.doi.org/10.18821/0507-4088-2016-61-3-119-125.

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The DNA of human herpesviruses (HHV), including the herpes simplex virus (HSV) and cytomegalovirus (CMV), is often identified in ejaculates of patients with urogenital diseases and infertility. At least a part of viral DNA is associated with cell fraction of ejaculate. However, it remains unclear how the semen is infected by the virus. It can be located in gametes or be capable of infecting mature germ cells, including motile sperm cells. In order to resolve this issue, interactions of the CMV and HSV with human sperm cells were studied using an original optimized model of the herpesviral infe

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Liu, Yu, Xi-Qiu Xu, Biao Zhang, et al. "Bowman‒Birk Inhibitor Suppresses Herpes Simplex Virus Type 2 Infection of Human Cervical Epithelial Cells." Viruses 10, no. 10 (2018): 557. http://dx.doi.org/10.3390/v10100557.

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The Bowman‒Birk inhibitor (BBI), a protease inhibitor derived from soybeans, has been extensively studied in anti-tumor and anti-inflammation research. We recently reported that BBI has an anti-HIV-1 property in primary human macrophages. Because HSV-2 infection plays a role in facilitating HIV-1 sexual transmission, we thus examined whether BBI has the ability to inhibit HSV-2 infection. We demonstrated that BBI could potently inhibit HSV-2 replication in human cervical epithelial cells (End1/E6E7). This BBI-mediated HSV-2 inhibition was partially through blocking HSV-2-mediated activation of

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Stavropoulos, Tom A., and Craig A. Strathdee. "An Enhanced Packaging System for Helper-Dependent Herpes Simplex Virus Vectors." Journal of Virology 72, no. 9 (1998): 7137–43. http://dx.doi.org/10.1128/jvi.72.9.7137-7143.1998.

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ABSTRACT Helper-dependent herpes simplex virus (HSV) vectors (amplicons) show considerable promise to provide for long-term transduced-gene expression in most cell types. The current packaging system of choice for these vectors involves cotransfection with a set of five overlapping cosmids that encode the full HSV type 1 (HSV-1) helper virus genome from which the packaging (pac) elements have been deleted. Although both the helper virus and the HSV amplicon can replicate, only the latter is packaged into infectious viral particles. Since the titers obtained are too low for practical applicatio

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Burbelo, Peter D., Yo Hoshino, Hannah Leahy, et al. "Serological Diagnosis of Human Herpes Simplex Virus Type 1 and 2 Infections by Luciferase Immunoprecipitation System Assay." Clinical and Vaccine Immunology 16, no. 3 (2009): 366–71. http://dx.doi.org/10.1128/cvi.00350-08.

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ABSTRACT Highly quantitative and high-throughput serological tests for evaluation of humoral responses to herpes simplex virus 1 (HSV-1) and HSV-2 are not available. The efficacy of luciferase immunoprecipitation system (LIPS) assays for antibody profiling and serologic diagnosis of HSV-1 and HSV-2 infection was investigated using a panel of five recombinant HSV antigens. Plasma samples from subjects seropositive for HSV-1 and/or HSV-2 or seronegative for HSV-1 and HSV-2 that had previously been analyzed by Western blotting and the Focus Plexus immunoassay were evaluated. The LIPS test measuri

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Andrieieva, O. G., V. I. Yanchenko, V. S. Vasylyk, P. A. Dyachenko, and L. V. Muravskya. "Anxiety-depressive syndrome in patients with damage to the central nervous system by herpes viruses." Reports of Vinnytsia National Medical University 25, no. 1 (2021): 57–61. http://dx.doi.org/10.31393/reports-vnmedical-2021-25(1)-10.

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Annotation. Purpose of work – a study of the prevalence and severity of anxiety-depressive syndrome based on the Hospital Anxiety and Depression Scale (HADS) in patients with damage to the nervous system of hepatic virus etiology. In this study, 2 groups of 30 people took part. The first group (main) is 30 people from a verified diagnosis of herpesviral damage to the nervous system aged 14 to 74 years. Viruses were in the stage of activation and persistence. The second group (control), almost healthy people – 30 people. There were 20 women and 10 men in each group. Diagnoses: Encephalitis, men

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Mavrov, G. I., T. V. Osinska, Yu V. Shcherbakova, D. D. Kurushin, and I. V. Kalashnikovа. "Sexually transmitted infections in the penitentiary system (analysis of scientific publications and own data)." Ukrainian Journal of Dermatology, Venerology, Cosmetology, no. 2 (June 29, 2021): 79–84. http://dx.doi.org/10.30978/ujdvk2021-2-79.

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Objective — assessing the current prevalence of sexually transmitted infections (STIs) and HIV in prisons in the context of a holistic consideration of the problem, and taking into account our own pilot studies on the prevalence of herpes simplex virus infection type 1 (HSV-1) and disorders of the psycho-emotional state of patients. Materials and methods. The search was carried out in accordance with the recommendations of PRISMA 2009, 2020 (The Preferred Reporting Items for Systematic reviews and Meta-Analyses). The data of own research of 33 convicted men and 29 women are also presente

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Arvin, Ann M., and Charles G. Prober. "Herpes Simplex Virus Infections: The Genital Tract and the Newborn." Pediatrics In Review 13, no. 3 (1992): 107–11. http://dx.doi.org/10.1542/pir.13.3.107.

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There are six recognized members of the human herpes group of viruses. These include type 1 and type 2 herpes simplex viruses (HSV-1 and HSV-2), cytomegalovirus (CMV), Epstein-Barr virus (EBV), varicellazoster virus (VZV), and human herpes virus type 6 (HHV-6). These ubiquitous double-stranded DNA viruses are relatively large and lipid-enveloped. The capacity to induce a state of latency in the infected host has been proved for all of the herpes viruses. That is, after primary infection, the viruses remain forever with the host with the possibility for subsequent reactivations. The mechanisms

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Maughan-Brown, Brendan, Gavin George, Sean Beckett, et al. "Age-disparate partnerships and HSV-2 among adolescent girls and young women in South Africa: implications for HIV infection risk." Sexually Transmitted Infections 95, no. 6 (2019): 443–48. http://dx.doi.org/10.1136/sextrans-2018-053577.

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ObjectiveThere is an urgent need to understand high HIV-infection rates among young women in sub-Saharan Africa. While age-disparate partnerships have been characterised with high-risk sexual behaviours, the mechanisms through which these partnerships may increase HIV-risk are not fully understood. This study assessed the association between age-disparate partnerships and herpes simplex virus type-2 (HSV-2) infection, a factor known to increase HIV-infection risk.MethodsCross-sectional face-to-face questionnaire data, and laboratory HSV-2 and HIV antibody data were collected among a representa

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DA SILVA, Samya Jezine, Mauro Jorge CABRAL-CASTRO, Maria Angélica GUIMARÃES, José Mauro PERALTA, and Marzia PUCCIONI-SOHLER. "Cerebrospinal fluid challenges for the diagnosis of herpes simplex infection in the central nervous system." Arquivos de Neuro-Psiquiatria 78, no. 3 (2020): 163–68. http://dx.doi.org/10.1590/0004-282x20190179.

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Abstract Herpes simplex virus (HSV) is a cause of a severe disease of the central nervous system (CNS) in humans. The demonstration of specific antibodies in the cerebrospinal fluid (CSF) may contribute to the retrospective neurological diagnosis. However, the commercial immunological tests for HSV infection are for use in serum samples. Objective: The aim of the present study was to adapt a commercial kit anti-HSV IgG used for serum samples to be performed with a CSF sample. Methods: Forty CSF specimens from 38 patients with suspected CNS HSV infection were serially diluted for detecting anti

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Yavru, Sibel, Mehmet Özdemir, and Bahadır Feyzioğlu. "Laboratory Diagnosis of Pediatric Herpesvirus Infections of the Central Nervous System by a Multiplex Polymerase Chain Reaction Assay and Intrathecal Antibodies." Journal of Pediatric Infectious Diseases 13, no. 03 (2018): 178–84. http://dx.doi.org/10.1055/s-0038-1639616.

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Abstract Introduction Central nervous system (CNS) viral infections are a serious problem requiring accurate diagnosis and treatment. Human herpesviruses (HHVs) are an important cause of these infections. Recent research has focused on new diagnostic methods allowing accurate and rapid identification of viral infections because there are still diagnostic difficulties for these infections. This study was done to determine the etiologic role of human herpes viruses and to obtain information that will contribute to the diagnostic algorithm in suspected cases of viral encephalitis or aseptic menin

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Diefenbach, Russell J., April Davis, Monica Miranda-Saksena, et al. "The Basic Domain of Herpes Simplex Virus 1 pUS9 Recruits Kinesin-1 To Facilitate Egress from Neurons." Journal of Virology 90, no. 4 (2015): 2102–11. http://dx.doi.org/10.1128/jvi.03041-15.

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ABSTRACTThe alphaherpesviral envelope protein pUS9 has been shown to play a role in the anterograde axonal transport of herpes simplex virus 1 (HSV-1), yet the molecular mechanism is unknown. To address this, we used anin vitropulldown assay to define a series of five arginine residues within the conserved pUS9 basic domain that were essential for binding the molecular motor kinesin-1. The mutation of these pUS9 arginine residues to asparagine blocked the binding of both recombinant and native kinesin-1. We next generated HSV-1 with the same pUS9 arginine residues mutated to asparagine (HSV-1p

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Sanaee, Layli, Monica Taljaard, Tim Karnauchow, and Jeffrey J. Perry. "Clinical and Laboratory Findings That Differentiate Herpes Simplex Virus Central Nervous System Disease from Enteroviral Meningitis." Canadian Journal of Infectious Diseases and Medical Microbiology 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/3463909.

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Background. It can be difficult for clinicians to distinguish between the relatively benign enteroviral (EnV) meningitis and potentially lethal herpes simplex virus (HSV) central nervous system (CNS) disease. Very limited evidence currently exists to guide them.Objective. This study sought to identify clinical features and cerebrospinal fluid (CSF) findings associated with HSV CNS disease.Methods. Given that PCR testing often is not immediately available, this chart review study sought to identify clinical and cerebrospinal fluid (CSF) findings associated with HSV meningitis over a 6-year peri

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Ptaszyńska-Sarosiek, Iwona, Justyna Dunaj, Agata Zajkowska, et al. "Post-mortem detection of six human herpesviruses (HSV-1, HSV-2, VZV, EBV, CMV, HHV-6) in trigeminal and facial nerve ganglia by PCR." PeerJ 6 (January 9, 2019): e6095. http://dx.doi.org/10.7717/peerj.6095.

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BackgroundAmong over 100 types ofHerpesviridaeviruses, eight can infect humans: herpes simplex viruses (HSV-1, HSV-2), varicella zoster virus (VZV), cytomegalovirus (CMV), Epstein-Barr virus (EBV), and human herpesviruses 6, 7, and 8 (HHV-6, HHV-7, HHV-8). After initial infection, the viruses remain latent for the lifetime of the host. The aim of this study was to determine the distribution of six different herpesviruses: HSV-1, HSV-2, VZV, EBV, CMV, and HHV-6 in trigeminal and facial nerve ganglia among a random group of Polish population.MethodsThe studied group consisted of 47 individuals (

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Gosselin, J., L. Flamand, M. D'Addario, et al. "Modulatory effects of Epstein-Barr, herpes simplex, and human herpes-6 viral infections and coinfections on cytokine synthesis. A comparative study." Journal of Immunology 149, no. 1 (1992): 181–87. http://dx.doi.org/10.4049/jimmunol.149.1.181.

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Abstract Herpesviruses such as EBV, HSV, and human herpes virus-6 (HHV-6) have a marked tropism for cells of the immune system and therefore infection by these viruses may result in alterations of immune functions, leading at times to a state of immunosuppression. We report the results of a comparative study in which we found that EBV, HSV-1, and HHV-6 act differentially on the immune system with regard to their effect on the synthesis of IL-1 beta, IL-6, and TNF-alpha, i.e., three immunoregulatory cytokines mainly secreted by activated monocytes/macrophages. Using the polymerase chain reactio

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Tang, Y., J. Li, S. Zhao, and J. Liu. "Killing Effect of the Herpes Simplex Virus Thymidine Kinase/Ganciclovir Enzyme/Prodrug System on Human Nasopharyngeal Carcinoma Cells." Journal of International Medical Research 35, no. 4 (2007): 433–41. http://dx.doi.org/10.1177/147323000703500401.

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A promising new approach for the gene therapy of cancer is the introduction of the herpes simplex virus thymidine kinase (HSV tk) gene into tumour cells, where the HSV tk gene product converts the non-toxic prodrug ganciclovir (GCV) into its cytotoxic metabolite. We constructed a recombinant plasmid containing the HSV tk gene using standard molecular biology techniques in order to investigate whether the HSV tk/GCV enzyme/prodrug system could kill the human nasopharyngeal carcinoma cell line HNE-1. The recombinant plasmid pcDNA3.1(–) CMV.TK was transfected into the HNE-1 cells by electroporati

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Zhang, Binman, Yuncheng Li, Ping Yang та ін. "Herpes Simplex Virus Type 2 Blocks IFN-β Production through the Viral UL24 N-Terminal Domain-Mediated Inhibition of IRF-3 Phosphorylation". Viruses 16, № 10 (2024): 1601. http://dx.doi.org/10.3390/v16101601.

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Herpes simplex virus type 2 (HSV-2) is a sexually transmitted virus, the cause of genital herpes, and its infection can increase the risk of HIV-1 infection. After initial infection, HSV-2 can establish lifelong latency within the nervous system, which is likely associated with the virus-mediated immune evasion. In this study, we found that HSV-2 UL24 significantly inhibited the activation of the IFN-β promoter and the production of IFN-β at both mRNA and protein levels. Of importance, the inhibitory effect of HSV-2 on IFN-β production was significantly impaired in the context of HSV-2 infecti

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Patel, Navin, Lynn Kauffmann, Geri Baniewicz, Michael Forman, Martin Evans, and David Scholl. "Confirmation of Low-Titer, Herpes Simplex Virus-Positive Specimen Results by the Enzyme-Linked Virus-Inducible System (ELVIS) Using PCR and Repeat Testing." Journal of Clinical Microbiology 37, no. 12 (1999): 3986–89. http://dx.doi.org/10.1128/jcm.37.12.3986-3989.1999.

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The ELVIS HSV Id test kit (an enzyme-linked virus-inducible system) (Diagnostic Hybrids, Inc.) uses genetically engineered BHK cells to produce a detectable enzyme, beta-galactosidase, upon infection with either herpes simplex virus (HSV) type 1 (HSV-1) or HSV-2. Twenty six ELVIS-positive clinical specimens were selected for study by PCR and with monoclonal antibodies because they were originally low-titer HSV-positive specimens by ELVIS but HSV antibody nonreactive upon follow-up staining of the ELVIS monolayer. Twenty-one of 26 specimens were frozen, thawed, and retested with ELVIS without r

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Read, Steven J., and John B. Kurtz. "Laboratory Diagnosis of Common Viral Infections of the Central Nervous System by Using a Single Multiplex PCR Screening Assay." Journal of Clinical Microbiology 37, no. 5 (1999): 1352–55. http://dx.doi.org/10.1128/jcm.37.5.1352-1355.1999.

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A multiplex PCR assay that detects the four commonest causes of viral meningitis and encephalitis in the United Kingdom (herpes simplex virus [HSV] type 1 [HSV-1], HSV type 2 [HSV-2], varicella-zoster virus [VZV], and enteroviruses) was developed, and its sensitivity was compared with those of similar assays described previously for this application. Compared to the previous assays, this single multiplex PCR assay had higher molecular sensitivities for the detection for each of the viruses and improved utility for routine use in a diagnostic laboratory. The assay was used to test a series of 1

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Granato, Paul A., Brenda R. Alkins, Belinda Yen-Lieberman, et al. "Comparative Evaluation of AmpliVue HSV 1+2 Assay with ELVIS Culture for Detecting Herpes Simplex Virus 1 (HSV-1) and HSV-2 in Clinical Specimens." Journal of Clinical Microbiology 53, no. 12 (2015): 3922–25. http://dx.doi.org/10.1128/jcm.01905-15.

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The AmpliVue HSV 1+2 assay was compared to the ELVIS HSV ID and D3Typing Culture System for the qualitative detection and differentiation of herpes simplex virus 1 (HSV-1) and HSV-2 DNA in 1,351 cutaneous and mucocutaneous specimens. Compared to ELVIS, AmpliVue had sensitivities of 95.7 and 97.6% for detecting HSV-1 and HSV-2, respectively. Following arbitration of discordant results by an independent molecular method, the AmpliVue assay had a resolved sensitivity and specificity of 99.2 and 99.7%, respectively, for both HSV-1 and HSV-2, whereas ELVIS had a resolved sensitivity of 87.1% for HS

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Basu, Maitreyi, Sibarjun Ghosh, Abhijit Dutta, and Sudip Saha. "Disseminated Herpes Simplex Infection in a Neonate." Journal of Neonatology 21, no. 4 (2007): 275–76. http://dx.doi.org/10.1177/097321790702100415.

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Herpes simplex virus (HSV) infection in a newborn is commonly due to HSV 2 and less commonly due to HSV 1.1,2 Mixed HSV 1 & 2 infection in newborn is rarely reported.3 Neonatal HSV infection can present as- a) Localized skin, eye and mouth (SEM) affection; b) Central nervous system (CNS) disease or c)Disseminated disease.1,4,5 We report an unusual case of HSV infection in a neonate due both HSV 1 & HSV 2. It led to initial manifestation just like septicemia and ultimately prolonged cholestasis that responded to acyclovir therapy.

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Di Stefano, Alessandro, Chiara Alcantarini, Cristiana Atzori, et al. "Cerebrospinal fluid biomarkers in patients with central nervous system infections: a retrospective study." CNS Spectrums 25, no. 3 (2019): 402–8. http://dx.doi.org/10.1017/s1092852919000981.

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BackgroundCentral nervous system (CNS) may be infected by several agents, resulting in different presentations and outcomes. Analysis of cerebrospinal fluid (CSF) markers could be helpful to differentiate specific conditions and setting an appropriate therapy.MethodsPatients presenting with signs and symptoms were enrolled if, before receiving a diagnostic lumbar puncture, signed a written informed consent. We analyzed CSF indexes of blood–brain barrier permeability (CSF to serum albumin ratio or CSAR), inflammation (CSF to serum IgG ratio, neopterin), amyloid deposition (1–42 β-amyloid), neur

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Ahmed, Saima, Patrick van Zalm, Emily A. Rudmann, et al. "Using CSF Proteomics to Investigate Herpesvirus Infections of the Central Nervous System." Viruses 14, no. 12 (2022): 2757. http://dx.doi.org/10.3390/v14122757.

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Herpesviruses have complex mechanisms enabling infection of the human CNS and evasion of the immune system, allowing for indefinite latency in the host. Herpesvirus infections can cause severe complications of the central nervous system (CNS). Here, we provide a novel characterization of cerebrospinal fluid (CSF) proteomes from patients with meningitis or encephalitis caused by human herpes simplex virus 1 (HSV-1), which is the most prevalent human herpesvirus associated with the most severe morbidity. The CSF proteome was compared with those from patients with meningitis or encephalitis due t

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Peng, Tao, Jia Zhu, Alexis Klock, et al. "Evasion of the Mucosal Innate Immune System by Herpes Simplex Virus Type 2." Journal of Virology 83, no. 23 (2009): 12559–68. http://dx.doi.org/10.1128/jvi.00939-09.

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ABSTRACT Understanding the mechanisms by which herpes simplex virus (HSV) evades host immune defenses is critical to defining new approaches for therapy and prevention. We performed transcriptional analyses and immunocytochemistry on sequential biopsy specimens of lesional tissue from the acute through the posthealing phases of recurrent mucocutaneous HSV-2 infection. Histological analysis of these biopsy specimens during the acute stage revealed a massive infiltration of T cells, as well as monocytes/macrophages, a large amount of myeloid, and a small number of plasmacytoid dendritic cells, i

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Ch'ng, T. H., P. G. Spear, F. Struyf, and L. W. Enquist. "Glycoprotein D-Independent Spread of Pseudorabies Virus Infection in Cultured Peripheral Nervous System Neurons in a Compartmented System." Journal of Virology 81, no. 19 (2007): 10742–57. http://dx.doi.org/10.1128/jvi.00981-07.

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ABSTRACT The molecular mechanisms underlying the directional neuron-to-epithelial cell transport of herpesvirus particles during infection are poorly understood. To study the role of the viral glycoprotein D (gD) in the directional spread of herpes simplex virus (HSV) and pseudorabies virus (PRV) infection, a culture system consisting of sympathetic neurons or epithelial cells in different compartments was employed. We discovered that PRV infection could spread efficiently from neurons to cells and back to neurons in the absence of gD, the viral ligand required for entry of extracellular parti

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Sutter, Julia, Jennifer L. Hope, Brian Wigdahl, Vandana Miller, and Fred C. Krebs. "Immunological Control of Herpes Simplex Virus Type 1 Infection: A Non-Thermal Plasma-Based Approach." Viruses 17, no. 5 (2025): 600. https://doi.org/10.3390/v17050600.

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Herpes simplex virus type 1 (HSV-1) causes a lifelong infection due to latency established in the trigeminal ganglia, which is the source of recurrent outbreaks of cold sores. The lifelong persistence of HSV-1 is further facilitated by the lack of cure strategies, unsuccessful vaccine development, and the inability of the host immune system to clear HSV-1. Despite the inefficiencies of the immune system, the course of HSV-1 infection remains under strict immunological control. Specifically, HSV-1 is controlled by a CD8+ T cell response that is cytotoxic to HSV-1-infected cells, restricts acute

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Chyad, Haitham Salman, Raniah Ali Mustafa, and Kawther Thabt Saleh. "Hand Print Recognition System based on FP-Growth Algorithm." Webology 19, no. 1 (2022): 980–1000. http://dx.doi.org/10.14704/web/v19i1/web19067.

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Hand print recognition system received great interest in the recent few years such as human-computer interaction, computer vision, and computer graphics. In this paper, proposed system for recognition human handprint based on FP-growth algorithm, the system consists of three-stage. The first stage the detection algorithm using HSV color space, canny algorithm and contrast enhancement for grayscale. In this stage separate skin area in-handprint image through first HSV color space converting RGB to HSV color space as well as conducting specific rules for determining the skin area. And then appli

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Park, Ho-Sik. "Vehicle Tracking System using HSV Color Space at nighttime." Journal of Korea Institute of Information, Electronics, and Communication Technology 8, no. 4 (2015): 270–74. http://dx.doi.org/10.17661/jkiiect.2015.8.4.270.

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Hauser, Ronald G., Sheldon M. Campbell, Cynthia A. Brandt, and Shiyi Wang. "Cost-Effectiveness Study of Criteria for Screening Cerebrospinal Fluid To Determine the Need for Herpes Simplex Virus PCR Testing." Journal of Clinical Microbiology 55, no. 5 (2017): 1566–75. http://dx.doi.org/10.1128/jcm.00119-17.

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ABSTRACT The absence of markers of inflammation in the cerebrospinal fluid (CSF) commonly predicts the absence of herpes simplex virus (HSV) central nervous system (CNS) infection. Consequently, multiple authors have proposed and validated criteria for deferring HSV PCR testing of CSF in immunocompetent hosts with normal CSF white blood cell and protein levels (≤5 cells/mm 3 and ≤50 mg/dl, respectively). Hosts are considered immunocompetent if they are ≥2 years old and have not had HIV or an organ transplant. Adoption of the criteria may erroneously exclude HSV-infected persons from a necessar

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Norgren, Robert B., John H. McLean, H. Curt Bubel, Arden Wander, David I. Bernstein, and Michael N. Lehman. "Anterograde transport of HSV-1 and HSV-2 in the visual system." Brain Research Bulletin 28, no. 3 (1992): 393–99. http://dx.doi.org/10.1016/0361-9230(92)90038-y.

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Rogalin, Henry B., and Ekaterina E. Heldwein. "Characterization of Vesicular Stomatitis Virus Pseudotypes Bearing Essential Entry Glycoproteins gB, gD, gH, and gL of Herpes Simplex Virus 1." Journal of Virology 90, no. 22 (2016): 10321–28. http://dx.doi.org/10.1128/jvi.01714-16.

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ABSTRACTHerpes simplex viruses (HSVs) are unusual in that unlike most enveloped viruses, they require at least four entry glycoproteins, gB, gD, gH, and gL, for entry into target cells in addition to a cellular receptor for gD. The dissection of the herpes simplex virus 1 (HSV-1) entry mechanism is complicated by the presence of more than a dozen proteins on the viral envelope. To investigate HSV-1 entry requirements in a simplified system, we generated vesicular stomatitis virus (VSV) virions pseudotyped with HSV-1 essential entry glycoproteins gB, gD, gH, and gL but lacking the native VSV fu

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Bello-Morales, Raquel, Sabina Andreu, and José Antonio López-Guerrero. "The Role of Herpes Simplex Virus Type 1 Infection in Demyelination of the Central Nervous System." International Journal of Molecular Sciences 21, no. 14 (2020): 5026. http://dx.doi.org/10.3390/ijms21145026.

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Herpes simplex type 1 (HSV-1) is a neurotropic virus that infects the peripheral and central nervous systems. After primary infection in epithelial cells, HSV-1 spreads retrogradely to the peripheral nervous system (PNS), where it establishes a latent infection in the trigeminal ganglia (TG). The virus can reactivate from the latent state, traveling anterogradely along the axon and replicating in the local surrounding tissue. Occasionally, HSV-1 may spread trans-synaptically from the TG to the brainstem, from where it may disseminate to higher areas of the central nervous system (CNS). It is n

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Kodukula, Padma, Ting Liu, Nico Van Rooijen, Martine J. Jager, and Robert L. Hendricks. "Macrophage Control of Herpes Simplex Virus Type 1 Replication in the Peripheral Nervous System." Journal of Immunology 162, no. 5 (1999): 2895–905. http://dx.doi.org/10.4049/jimmunol.162.5.2895.

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Abstract After corneal infection, herpes simplex virus type 1 (HSV-1) invades sensory neurons with cell bodies in the trigeminal ganglion (TG), replicates briefly, and then establishes a latent infection in these neurons. HSV-1 replication in the TG can be detected as early as 2 days after corneal infection, reaches peak titers by 3–5 days after infection, and is undetectable by 7–10 days. During the period of HSV-1 replication, macrophages and γδ TCR+ T lymphocytes infiltrate the TG, and TNF-α, IFN-γ, the inducible nitric oxide synthase (iNOS) enzyme, and IL-12 are expressed. TNF-α, IFN-γ, an

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Minjolle, Sophie, C. Michelet, I. Jusselin, M. Joannes, F. Cartier, and R. Colimon. "Amplification of the Six Major Human Herpesviruses from Cerebrospinal Fluid by a Single PCR." Journal of Clinical Microbiology 37, no. 4 (1999): 950–53. http://dx.doi.org/10.1128/jcm.37.4.950-953.1999.

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We used a novel type of primer system, a system that uses stair primers, in which the primer sequences are based on consensus sequences in the DNA polymerase gene of herpesvirus to detect herpesviruses by PCR. A single PCR in a single tube detected the six major herpesviruses that infect the central nervous system: herpes simplex virus type 1 (HSV-1), and type 2 (HSV-2), cytomegalovirus (CMV), Epstein-Barr virus (EBV), varicella-zoster virus (VZV), and human herpesvirus 6 (HHV-6). We used the technique to analyze 142 cerebrospinal fluid (CSF) samples that had been stored at −80°C and compared

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Lehrer, Steven, та Peter H. Rheinstein. "Alignment of Alzheimer’s Disease Amyloid-β Peptide and Herpes Simplex Virus-1 pUL15 C-Terminal Nuclease Domain". Journal of Alzheimer's Disease Reports 4, № 1 (2020): 373–77. http://dx.doi.org/10.3233/adr-200231.

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Background: The cause of Alzheimer’s disease (AD) is poorly understood. Neurotropic microbes, particularly herpesviruses, might set off chronic neuroinflammation. Amyloid-β (Aβ) has antimicrobial properties and could represent a brain defense against infection. Objective: We searched for protein sequence alignment between herpes simplex virus type I (HSV-1) HSV-2, and Aβ. Methods: Protein data bank (pdb) structures for Aβ, HSV-1, and HSV-2 were searched on the RCSB Protein Data Bank. The protein structures were superimposed and aligned on PYMOL v 2.3.4. Results: For HSV-1 and Aβ, amino acid re

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Kim, Buyun, Eun-Bin Kwon, Hye Jin Yang, et al. "Vaccinium bracteatum Thunb Extract Inhibits HSV-1 Infection by Regulating ER Stress and Apoptosis." Antioxidants 11, no. 9 (2022): 1773. http://dx.doi.org/10.3390/antiox11091773.

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Herpes simplex Type 1 (HSV-1) is a neurotropic virus that infects the peripheral and central nervous system. Usually, after primary infection in epithelial cells, HSV-1 migrates retrograde to the peripheral nervous system (PNS), where it establishes a latent infection. HSV-1 can remain latent in the nervous system, and its reactivation in the brain can rarely cause acute HSV-1 encephalitis, often a life-threatening condition, or asymptomatic reactivations that could lead to neuronal damage and ultimately neurodegenerative disorders. Acyclovir and related nucleoside analogs have been used as th

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Rouse, Barry T., and D. Scott Schmid. "Fraternal Twins: The Enigmatic Role of the Immune System in Alphaherpesvirus Pathogenesis and Latency and Its Impacts on Vaccine Efficacy." Viruses 14, no. 5 (2022): 862. http://dx.doi.org/10.3390/v14050862.

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Although the establishment, maintenance and reactivation from alphaherpesvirus latency is far from fully understood, some things are now manifestly clear: Alphaherpesvirus latency occurs in neurons of the peripheral nervous system and control of the process is multifactorial and complex. This includes components of the immune system, contributions from non-neuronal cells surrounding neurons in ganglia, specialized nucleic acids and modifications to the viral DNA to name some of the most important. Efficacious vaccines have been developed to control both acute varicella and zoster, the outcome

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Svetlova, E. V., N. V. Balatskaya, S. V. Saakyan, et al. "The incidence of infection in tumor and eye fluid system, and specific humoral immunity to herpes viruses in patients with uveal melanoma." Problems of Virology 68, no. 1 (2023): 37–44. http://dx.doi.org/10.36233/0507-4088-154.

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Introduction. Studies aimed at a direct research of human herpes viruses (HHVs) in the tumor material and eye media have not been carried out so far. Research goal to establish the frequency of detection HHVs DNA in the biomaterial of the eye and blood and to assess the specific humoral immunity to the causative agents of herpes virus infections in patients with uveal melanoma. Materials and methods. 38 patients with the uveal tract tumor were examined for the presence of DNA of HHV types 1 and 2 (HSV-1, 2), Cytomegalovirus (CMV), Varicella Zoster virus (VZV), EpsteinBarr virus (EB

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Burgos, Javier S., Carlos Ramirez, Isabel Sastre, María J. Bullido, and Fernando Valdivieso. "Involvement of Apolipoprotein E in the Hematogenous Route of Herpes Simplex Virus Type 1 to the Central Nervous System." Journal of Virology 76, no. 23 (2002): 12394–98. http://dx.doi.org/10.1128/jvi.76.23.12394-12398.2002.

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ABSTRACT Apolipoprotein E (ApoE), a constituent of the lipoproteins, may be relevant in herpes simplex virus type 1 (HSV-1) infection of the central nervous system (CNS), since HSV-1 binds to human serum ApoE lipoproteins. This study demonstrates the involvement of ApoE in the hematogenous route of HSV-1 to the CNS.

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Bertram, Kirstie M., Naomi R. Truong, Jacinta B. Smith, et al. "Herpes Simplex Virus type 1 infects Langerhans cells and the novel epidermal dendritic cell, Epi-cDC2s, via different entry pathways." PLOS Pathogens 17, no. 4 (2021): e1009536. http://dx.doi.org/10.1371/journal.ppat.1009536.

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Skin mononuclear phagocytes (MNPs) provide the first interactions of invading viruses with the immune system. In addition to Langerhans cells (LCs), we recently described a second epidermal MNP population, Epi-cDC2s, in human anogenital epidermis that is closely related to dermal conventional dendritic cells type 2 (cDC2) and can be preferentially infected by HIV. Here we show that in epidermal explants topically infected with herpes simplex virus (HSV-1), both LCs and Epi-cDC2s interact with HSV-1 particles and infected keratinocytes. Isolated Epi-cDC2s support higher levels of infection than

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Bieńkowski, Kuba, Albert Bielaska, Ewelina Wesołek-Bielaska, Wojciech Kołodziej, Jakub Krzysztof Gałązka, and Magdalena Greszta. "Chronic fatigue syndrome related to herpes simplex viruses infection – a narrative review." Quality in Sport 17 (July 21, 2024): 52946. http://dx.doi.org/10.12775/qs.2024.17.52946.

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This article reviews the potential impact of herpes simplex viruses (HSV) on chronic fatigue syndrome (CFS). HSV-1 and HSV-2 are prevalent pathogens, with HSV-1 acquired early in life and HSV-2 typically transmitted sexually. Studies have shown an association between HSV and CFS, with HSV-1 detected in saliva and cerebrospinal fluid of CFS patients and elevated HSV-2 antibodies found in CFS patients. Immunological abnormalities, including increased pro-inflammatory cytokines and chemokines, suggest immune dysregulation in CFS patients infected with HSV. HSV infections can also disrupt the hypo

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Carr, Daniel J. J., Micaela Lee Montgomery та Derek Royer. "CD8+ T cells control HSV-1 replication in the nervous system but not the cornea in HSV-1 0ΔNLS-vaccinated mice lacking virus-neutralizing antibody". Journal of Immunology 200, № 1_Supplement (2018): 125.19. http://dx.doi.org/10.4049/jimmunol.200.supp.125.19.

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Abstract HSV-1 is a successful human pathogen that can elicit benign pathology including cold sores to more severe to extreme life-threatening manifestations like blinding necrotizing stromal keratitis and encephalitis. To date, there is no commercially available vaccine for HSV-1 despite many failed experimental prototypes. We have evaluated the use of a live-attenuated HSV-1 strain (HSV-1 0ΔNLS) as a vaccine in a mouse model of ocular infection. This vaccine has been shown to prevent virus replication, spread, and establishment of latency while functionally preserving the visual axis and cor

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Basso, Monica, Daniela Zago, Irene Pozzetto, et al. "Viral Molecular Testing of Cerebrospinal Fluid in Adults with Suspected Central Nervous System Infection in an Italian University Hospital Laboratory: A Retrospective Study on 1462 Consecutive Patients." Open Microbiology Journal 15, no. 1 (2021): 26–35. http://dx.doi.org/10.2174/1874285802115010026.

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Background: Generally, about half of the patients with central nervous system infections cases remain unexplained. Therefore, we aimed to describe which viruses were detected in unselected patients with a suspected central nervous system infection and the first diagnostic workflow in a university hospital laboratory. Methods: A comprehensive virus testing in cerebrospinal fluid with an in-house real-time PCR method was employed. Determining how many and which viruses to test was at the full discretion of the treating physician. Results: 1462 patients were evaluated from 2011 to 2017 and 9 898

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Ragupathy, Viswanath, Wang Xue, Ji Tan, Krishnakumar Devadas, Yamei Gao, and Indira Hewlett. "Progesterone augments cell susceptibility to HIV-1 and HIV-1/HSV-2 co-infections." Journal of Molecular Endocrinology 57, no. 3 (2016): 185–99. http://dx.doi.org/10.1530/jme-16-0138.

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In human immunodeficiency virus type 1 (HIV-1)-infected women, oral or injectable progesterone containing contraceptive pills may enhance HIV-1 acquisition in vivo, and the mechanism by which this occurs is not fully understood. In developing countries, Herpes simplex virus type-2 (HSV-2) co-infection has been shown to be a risk for increase of HIV-1 acquisition and, if co-infected women use progesterone pills, infections may increase several fold. In this study, we used an in vitro cell culture system to study the effects of progesterone on HIV-1 replication and to explore the molecular mecha

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Vieira, Valdimara C., and Marcelo A. Soares. "The Role of Cytidine Deaminases on Innate Immune Responses against Human Viral Infections." BioMed Research International 2013 (2013): 1–18. http://dx.doi.org/10.1155/2013/683095.

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The APOBEC family of proteins comprises deaminase enzymes that edit DNA and/or RNA sequences. The APOBEC3 subgroup plays an important role on the innate immune system, acting on host defense against exogenous viruses and endogenous retroelements. The role of APOBEC3 proteins in the inhibition of viral infection was firstly described for HIV-1. However, in the past few years many studies have also shown evidence of APOBEC3 action on other viruses associated with human diseases, including HTLV, HCV, HBV, HPV, HSV-1, and EBV. APOBEC3 inhibits these viruses through a series of editing-dependent an

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Avitabile, Elisa, Laura Menotti, Barbara Giordani, Vanessa Croatti, Carola Parolin, and Beatrice Vitali. "Vaginal Lactobacilli Supernatants Protect from Herpes Simplex Virus Type 1 Infection in Cell Culture Models." International Journal of Molecular Sciences 25, no. 5 (2024): 2492. http://dx.doi.org/10.3390/ijms25052492.

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A healthy vaginal microbiota hosts Lactobacillus as the most predominant genus. Lactobacilli play a role in human health through the production of diverse antimicrobial substances that can act against human pathogens or modulate the immune system. Previous reports highlighted the ability of vaginal lactobacilli to counteract viruses causing STIs, e.g., HIV-1 and HSV-2. In this report, we analyze the activity of supernatants of vaginal lactobacilli against HSV-1 infection, which is becoming increasingly relevant as a STI. We show that the supernatants of two vaginal Lactobacillus species (i.e.,

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Chen, Shih-Heng, Hui-Wen Yao, Wen-Yen Huang, et al. "Efficient Reactivation of Latent Herpes Simplex Virus from Mouse Central Nervous System Tissues." Journal of Virology 80, no. 24 (2006): 12387–92. http://dx.doi.org/10.1128/jvi.01232-06.

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ABSTRACT For decades, numerous ex vivo studies have documented that latent herpes simplex virus (HSV) reactivates efficiently from ganglia, but rarely from the central nervous systems (CNS), of mice when assayed by mincing tissues before explant culture, despite the presence of viral genomes in both sites. Here we show that 88% of mouse brain stems reactivated latent virus when they were dissociated into cell suspensions before ex vivo explant culture. The efficient reactivation of HSV from the mouse CNS was demonstrated with more than one viral strain, viral serotype, and mouse strain, furthe

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