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Dissertations / Theses on the topic 'Human antigen presenting cells'

Author: Grafiati

Published: 31 May 2025

Last updated: 31 July 2025

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1

Brooks, C. F. "Antigen presenting cells in human peripheral blood." Thesis, University of Manchester, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234349.

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2

Al-Bader, Tamara. "Effects of bacterial adjuvants on human antigen presenting cells." Thesis, University of Southampton, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268411.

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3

Neil, Stuart John Douglas. "Lentiviral mediated gene delivery to human antigen presenting cells." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251820.

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4

Wyss-Coray, Anton. "The human T lymphocyte as an antigen presenting cell /." [S.l : s.n.], 1993. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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5

Reuter, Morgan Ann. "Mycobacterium tuberculosis-induced changes in HIV-1 trafficking in human antigen presenting cells." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1278699683.

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6

Funderburg, Nicholas Thomas. "Human beta defensin 3 linking innate and adaptive immune responses /." Connect to text online, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1189084245.

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Thesis (Ph. D.)--Case Western Reserve University, 2007.<br>[School of Medicine] Department of Molecular Biology and Microbiology. Includes bibliographical references. Available online via OhioLINK's ETD Center.

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7

Funderburg, Nicholas Thomas. "Human Beta Defensin 3: Linking Innate and Adaptive Immune Responses." Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1189084245.

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8

Sanders, Theodore James. "Production of retinoic acid by antigen presenting cells in the healthy and inflamed human intestine." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8648.

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Murine small intestinal CD103+ dendritic cells (DCs) produce retinoic acid (RA) through retinaldehyde dehydrogenase (RALDH) activity, thereby inducing ‘gut-homing’ α4β7 and CCR9 on T cells they activate, enhancing TGF-β-mediated induction of Foxp3+ regulatory T cells and suppressing induction of pro-inflammatory TH17 cells. RALDH activity of CD103+ DCs is reduced in mouse models of inflammatory bowel disease (IBD) but the role of RALDH activity in human intestinal DCs in the pathogenesis of IBD is undefined. This project aimed to determine the influence of inflammation on RALDH activity of ant

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9

Mayer, Wolfgang. "The antigen presenting cell in the human cornea – functional and morphological evaluation." Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-143669.

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10

Hutton, Andrew J. "Characterisation of the human lung fibroblasts ability to act as an antigen presenting cell for T helper cells of the immune system." Thesis, University of Southampton, 2015. https://eprints.soton.ac.uk/416623/.

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T helper cells of the immune system are critical in mediating immune responses in the lung. Through the release of cytokines, T helper cells direct the wider immune response against a range of pathogens and are considered indispensible for effective immunity. T cell activation is governed by the interaction with antigen-presenting cells (APCs), which mediate antigen-specific T cell activation and thus control immune responses in areas such as the lung. While T helper cell activation by APCs such as dendritic cells is well established, the role of fibroblasts in T helper cell activation in the

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11

Thomas, Saskia. "Aberrant response of human myeloid dendritic cells to microbial stimuli in patients with inflammatory bowel disease." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2011. http://dx.doi.org/10.18452/16340.

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In zahlreichen Studien konnte an Mausmodellen gezeigt werden, dass dendritische Zellen eine wichtige Rolle im Rahmen der mukosalen Immunabwehr spielen. Eine unkontrollierte Aktivierung immunologischer Effektorzellen durch antigenpräsentierende Zellen ist die Folge, welche die Antigene der luminalen Flora folglich falsch erkennen und damit zu einer Schädigung des Gewebes führen. In der Arbeit wurden humane CD1c+CD11c+CD14-CD19- myeloide dendritische Zellen (mDCs) aus dem peripheren Blut und der intestinalen Mukosa von CED Patienten sowie von gesunden Probanden phänotypisch und funktionell näher

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12

Bachmann, Michael, Holger Bartsch, Biji T. Kurien, et al. "A Novel Modular Antigen Delivery System for Immuno Targeting of Human 6-sulfo LacNAc-Positive Blood Dendritic Cells (SlanDCs)." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-186316.

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Background Previously, we identified a major myeloid-derived proinflammatory subpopulation of human blood dendritic cells which we termed slanDCs (e.g. Schäkel et al. (2006) Immunity 24, 767–777). The slan epitope is an O-linked sugar modification (6-sulfo LacNAc, slan) of P-selectin glycoprotein ligand-1 (PSGL-1). As slanDCs can induce neoantigen-specific CD4+ T cells and tumor-reactive CD8+ cytotoxic T cells, they appear as promising targets for an in vivo delivery of antigens for vaccination. However, tools for delivery of antigens to slanDCs were not available until now. Moreover, it is un

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13

Mayer, Wolfgang J. [Verfasser], and Daniel [Akademischer Betreuer] Kook. "The antigen presenting cell in the human cornea – functional and morphological evaluation / Wolfgang Mayer. Betreuer: Daniel Kook." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2012. http://d-nb.info/1023206048/34.

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14

Bachmann, Michael, Holger Bartsch, Biji T. Kurien, et al. "A Novel Modular Antigen Delivery System for Immuno Targeting of Human 6-sulfo LacNAc-Positive Blood Dendritic Cells (SlanDCs)." PLOS, 2011. https://tud.qucosa.de/id/qucosa%3A29020.

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Background Previously, we identified a major myeloid-derived proinflammatory subpopulation of human blood dendritic cells which we termed slanDCs (e.g. Schäkel et al. (2006) Immunity 24, 767–777). The slan epitope is an O-linked sugar modification (6-sulfo LacNAc, slan) of P-selectin glycoprotein ligand-1 (PSGL-1). As slanDCs can induce neoantigen-specific CD4+ T cells and tumor-reactive CD8+ cytotoxic T cells, they appear as promising targets for an in vivo delivery of antigens for vaccination. However, tools for delivery of antigens to slanDCs were not available until now. Moreover, it is un

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15

Ostrop, Jenny [Verfasser], Thomas [Akademischer Betreuer] Winkler, and Roland [Akademischer Betreuer] Lang. "Activation of human antigen-presenting cells by the mycobacterial cord factor and its glycolipid adjuvant analogue trehalose-6,6’-dibehenate / Jenny Ostrop. Gutachter: Thomas Winkler ; Roland Lang." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2015. http://d-nb.info/1076166482/34.

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16

Howard, Jennifer Ruth. "Role of human gamma-delta T lymphocytes in the instruction of the adaptive immune response against Plasmodium falciparum infection." Thesis, Bordeaux, 2015. http://www.theses.fr/2015BORD0110/document.

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Les phosphoantigènes (P-Ag) de P. falciparum (P.f.) induisent une forte activation et une expansion des lymphocytes T (LT) Vγ9Vδ2 par un mécanisme encore mal décrit. Les LT Vγ9Vδ2 actives inhibent le cycle sanguin de P. f. par des médiateurs cytotoxiques solubles, inhibant ainsi la capacité invasive des mérozoites. Il a été montre in vitro que des LT Vγ9Vδ2 activés par les P-Ag peuvent présenter des antigènes et activer les LT αβ, agissant ainsi comme des cellules présentatrices d’antigènes (APC). Cette fonction n’a cependant pas été démontrée dans un contexte physiopathologique. Le but de ce

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17

Yang, Tianyu. "Two novel mechanisms of MHC class I down-regulation in human cancer accelerated degradation of TAP-1 mRNA and disruption of TAP-1 protein function /." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1078192113.

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Thesis (Ph. D.)--Ohio State University, 2004.<br>Title from first page of PDF file. Document formatted into pages; contains x, 117 p.; also includes graphics (some col.) Includes bibliographical references (p. 99-117). Available online via OhioLINK's ETD Center

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18

Salabert, Nina. "Dynamique de la réponse immune aux vaccins : exploration par imagerie in vivo dans un modèle utilisant le primate non humain." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA114802.

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Ma thèse a permis de développer une nouvelle approche pour étudier, par imagerie in vivo, le comportement des cellules présentatrices d’antigènes (CPA) de la peau suite à la vaccination par voie intradermique chez le primate non-humain. Le ciblage des CPA a été réalisé par injection in vivo d’un anticorps monoclonal anti-HLA-DR fluorescent. L’effet sur les CPA d’un adjuvant (R-848, ligand du TLR7/8) et l’immuno-ciblage des cellules de Langerhans par une protéine de fusion vaccinale anti-VIH (anti-langérine-VIHGag) ont ainsi été évalués par imagerie in vivo, vidéomicroscopie confocale ex vivo e

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19

Adam, Lucille. "Dynamique de la réponse immunitaire précoce mise en place localement suite à l’injection d’un vaccin ADN associée à une électroporation chez le macaque cynomolgus." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA114812/document.

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La compréhension des mécanismes immunologiques précoces mis en place suite à l’administration de vaccins est encore de nos jours largement méconnue. Pourtant de plus en plus d’études démontrent l’importance de ces mécanismes très précoces faisant intervenir les acteurs de l’immunité innée dans la génération d’une réponse spécifique efficace après vaccination. La peau est un organe intéressant pour l'administration de vaccins du fait de sa richesse en cellules présentatrices d'antigènes (APC), qui sont des cellules essentielles dans la mise en place de la réponse immunitaire. L'administration p

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20

Gerber--Tichet, Elina. "Le rôle des cellules de Langerhans (LCs) au cours du processus de vaccination basé sur les adénovirus humains." Electronic Thesis or Diss., Université de Montpellier (2022-....), 2025. https://ged.scdi-montpellier.fr/florabium45/jsp/nnt.jsp?nnt=2025UMONT003.

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Les cellules de Langerhans (LCs) sont des cellules présentatrices d'antigènes (APCs) professionnelles résidentes de certains tissus ou muqueuses et font partie de notre première ligne de défense. Les LCs se trouvent non seulement dans certaines muqueuses et autres tissus lymphoïdes, mais aussi dans la peau, l'une des principales voies d'entrée des agents pathogènes. Impliquées dans de nombreuses réponses antivirales, les LCs sont capables de scanner l'environnement à la recherche d'agents pathogènes grâce à leurs projections cytoplasmiques. Outre la détection des pathogènes, les LCs jouent éga

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21

Todorova, Biliana. "Imagerie in vivo de la réponse immune locale à la vaccination par voie intradermique à l’aide d’un ADN plasmidique associée à l’électroporation chez le macaque cynomolgus." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA114837.

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L’électroporation (EP) in vivo est utilisée comme stratégie d’amélioration de la réponse immune induite par les vaccins ADN. Cependant son effet sur les acteurs du système immunitaire inné reste méconnu. Dans l’objectif de mettre en évidence le comportement cellulaire sur le site de la vaccination, nous avons développé des approches d’imagerie par fluorescence in vivo chez le macaque. Nos résultats montrent que l’EP locale, augmente non seulement la quantité et la distribution de l’antigène vaccinal, mais induit également la mobilisation et la migration des cellules de Langerhans. De plus, l’E

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22

Zheng, Biao. "Inductive interactions between antigen presenting cells and T cells." Thesis, Open University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314796.

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23

Vicente-Suarez, Ildefonso. "Immunomodulatory role of flagellin in antigen-presenting cells." [Tampa, Fla] : University of South Florida, 2007. http://purl.fcla.edu/usf/dc/et/SFE0002201.

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24

McCormick, P. Andrew. "Interaction of bovine antigen-presenting cells with mycobacteria." Thesis, University of Bristol, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.435849.

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25

Kalupahana, Ruwani Sagarika. "Interaction of Salmonella typhimurium with antigen presenting cells." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620666.

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26

Allan, Philip James. "The function of NOD2 in antigen presenting cells." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:773bf1c0-5dc6-40b7-97a1-9e70efdee1ae.

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Crohn’s disease (CD), a chronic inflammatory condition of the gut affecting 1:1000 of western populations, is thought to arise from a dysregulated immune response in a genetically susceptible individual. Polymorphisms in the ligand recognition domain of an intracellular pattern recognition receptor (PRR), NOD2, remain the strongest genetic risk factor for the development of CD. NOD2 directs autophagy in human DCs to facilitate bacterial destruction and antigen presentation; the CD-variant-NOD2 shows defects in this pathway. Recent work in the laboratory has demonstrated NOD2 signals to control

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27

Hewson, Timothy John. "Interactions of HIV-1 with antigen presenting cells." Thesis, University of Edinburgh, 2000. http://hdl.handle.net/1842/22307.

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Data in this thesis demonstrate that gp120 causes a decline of cell-surface CD4 from human macrophages <i>in vitro</i>. A mechanism for this loss is proposed based on observation that it is significantly more substantial when CCR-5-binding gp120, derived from M-tropic HIV-1 is used as opposed to CXCR-4-binding gp120. CD4 loss is absent from macrophages that fail to express surface CCR-5 due to homozygosity for the naturally occurring <i>ccr5</i><i>D32</i> mutation. It appears that CD4 loss by this novel CCR-5-dependent mechanism requires cross-linking of CCR-5, CD4 and gp120 at the cell surfac

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28

Frenger, Quentin. "Roles of autophagy-related proteins in antigen presentation by antigen presenting cells." Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAJ043.

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La présentation antigénique joue un rôle crucial dans l'immunité adaptative. Les protéines d'autophagie orchestrent la macroautophagie, un processus essentiel pour l'homéostasie cellulaire, et peuvent également être recrutées sur des membranes endolysosomales. Ces processus influencent la présentation antigénique. J'ai démontré que la macroautophagie n'est pas dérégulée dans les cellules mononuclées du sang périphérique des patients atteints de sclérodermie systémique. Cependant, les macrophages ne recrutent pas efficacement LC3 sur les phagosomes. Les lymphocytes B capturent l'antigène via le

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29

Rodionova, Elena. "Developing anti-tumor vaccines: Antigens and Antigen-presenting cells." [S.l. : s.n.], 2006. http://digbib.ubka.uni-karlsruhe.de/volltexte/1000006088.

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30

Herberg, Jethro Adam. "Antigen presenting genes and proteins of the human MHC." Thesis, King's College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298847.

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31

Hudson, Sarah. "Myeloid antigen presenting cell populations in the murine uterus /." Title page, abstract and contents only, 2000. http://web4.library.adelaide.edu.au/theses/09PH/09phh887.pdf.

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32

Chang, Nan-Hua. "Selective elimination of antigen-specific T cells by antigen-targeted drug-labeled antigen-presenting cell membranes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ27889.pdf.

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33

Bujdoso, R. "The role of antigen presenting cells in the activation of T cells." Thesis, University of Cambridge, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303811.

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34

Hine, Dominic William. "B cells as antigen-presenting cells in a model of rheumatoid arthritis." Thesis, University of Newcastle upon Tyne, 2013. http://hdl.handle.net/10443/2189.

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Rheumatoid arthritis (RA) is a multifaceted inflammatory autoimmune disease characterised by the infiltration of leukocytes into synovial joints leading to the destruction of articular cartilage and bone. Autoreactive CD4+ T cells producing inflammatory cytokines are implicated in disease pathogenesis. The clinical efficacy of B cell-depletion therapy is not dependent on clearance of autoantibodies suggesting a critical role for B cells as antigen presenting cells (APC). To elucidate the role of B cells in activating CD4+ T cells in RA, this project examined B cell- mediated antigen presentati

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35

Holst, Rutger van der. "TRAPC : a novel triggering receptor expressed on antigen presenting cells /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-427-3/.

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36

Drobbe, Lea [Verfasser]. "Inhibition of antigen presentation by primary antigen presenting cells through Helicobacter pylori / Lea Drobbe." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2019. http://d-nb.info/1202042465/34.

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37

Richer, Martin Joseph. "The role of antigen presenting cells in coxsackieviral-induced autoimmune diseases." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/23339.

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Susceptibility to autoimmune diseases is dictated by the interplay of genetic determinants and environmental factors including diet, toxins and infections. Viral infections have long been suspected to play a role in the etiology of several autoimmune disorders. In particular, coxsackieviruses are common human pathogens that have been linked to autoimmune myocarditis and type 1 diabetes (T1D). Evidence suggests that interactions between a pathogen and components of the innate immune system may influence the generation of a dysregulated adaptive response ultimately resulting in autoimmune diseas

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38

Glew, Elizabeth Jane. "The interaction of bovine viral diarrhoea virus with antigen presenting cells." Thesis, University of Reading, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312578.

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39

Trzaska, Timo [Verfasser]. "The role of granzyme B in antigen-presenting cells / Timo Trzaska." Ulm : Universität Ulm, 2021. http://d-nb.info/1234554968/34.

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40

Lukas, Dominika [Verfasser]. "Exploring the role of Smad7 in antigen presenting cells / Dominika Lukas." Mainz : Universitätsbibliothek Mainz, 2017. http://d-nb.info/1128342871/34.

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41

Pope, Melissa J. "Functional characterization of the T cells and antigen presenting cells of salmonella-infected mice /." Title page, abstract and table of contents only, 1992. http://web4.library.adelaide.edu.au/theses/09PH/09php8261.pdf.

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42

Lino, Andréia Cristina Leitão Correia Simão. "THE ROLE OF ANTIGEN PRESENTING CELLS IN IMMUNE REGULATION MEDIATED BY REGULATORY T CELLS." Doctoral thesis, Instituto de Ciências Biomédicas Abel Salazar, 2008. http://hdl.handle.net/10216/7249.

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43

Lino, Andréia Cristina Leitão Correia Simão. "THE ROLE OF ANTIGEN PRESENTING CELLS IN IMMUNE REGULATION MEDIATED BY REGULATORY T CELLS." Tese, Instituto de Ciências Biomédicas Abel Salazar, 2008. http://hdl.handle.net/10216/7249.

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44

Springer, Sebastian Hartmut. "The biochemistry of antigen presentation." Thesis, University of Oxford, 1996. http://ora.ox.ac.uk/objects/uuid:34d1afd2-fafc-4732-8e43-e00dcd8460d1.

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This thesis describes studies on the binding of peptides to the murine major histocompatibility complex (MHC) class I molecule H-2D<sup>b</sup> (D<sup>b</sup>). The expression of the recombinant soluble D<sup>b</sup> molecule in Chinese hamster ovary cells and its subsequent purification by nickel affinity chromatography, gel filtration, and preparative native isoelectric focusing are reported. The product is the correct molecule, homogeneous, a dimer of dimers, and free of endogenous peptide. A novel binding assay based on the enhancement of natural tryptophan fluorescence by the binding of p

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45

Pecora, Nicole Danielle. "TLR₂-dependent modulation of antigen presenting cell functions by mycobacterial lipoproteins." Cleveland, Ohio : Case Western Reserve University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1212611434.

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46

Wattendorf, Uta. "Towards receptor-specific targeting of antigen presenting cells with functionalized stealth microparticles /." Zürich : ETH, 2008. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=17540.

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47

Bergamin, Fabio. "Antigen-presenting cells and BAFF in porcine B-cell responses against FMDV /." Bern : [s.n.], 2007. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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48

Omilusik, Kyla Dione. "The requirement for competent antigen presenting dendritic cells and poised T cells for immune responses." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/36789.

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Immune responses are initiated by dendritic cells (DCs) that cross present exogenous antigen to naïve T cells. DC cross presentation is essential for generating primary immune responses, yet the mechanistic details remain undefined. Using a CD74⁻/⁻ mouse model, a CD74-MHC I association was shown to mediate trafficking of MHC I from the endoplasmic reticulum to endolysosomal compartments for antigenic loading. These studies describe a novel CD74-mediated cross presentation pathway in DCs that plays a major role in the generation of cytolytic T lymphocyte (CTL) responses against viral and cell-a

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49

Frankenberry, Marc A. "Critical features of antigen-specific and allospecific recognition by cytotoxic T lymphocytes." Morgantown, W. Va. : [West Virginia University Libraries], 2004. https://etd.wvu.edu/etd/controller.jsp?moduleName=documentdata&jsp%5FetdId=3476.

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Thesis (Ph. D.)--West Virginia University, 2004.<br>Title from document title page. Document formatted into pages; contains xii, 239 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.

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50

Kambarage, D. M. "Characterisation of non-lyphoid cells in the small intestinal lamina propria of the rat and the pig." Thesis, University of Bristol, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303748.

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