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Dissertations / Theses on the topic 'Human genetics – research – social aspects'

Author: Grafiati

Published: 27 July 2024

Last updated: 31 July 2025

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1

Poon, Martha A. "Of molecules & networks : tracing the connection between the distribution of samples, the production of genetic maps and the valuation of DNA in human genetics research." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=29404.

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This thesis takes the DNA molecule and its circulation between scientific researchers as an object of analysis. The study's objective was to investigate the techno-social mechanisms through which certain individual's genetic materials are imputed with research value. Two cases, representing two contrasting kinds of circulation practices, are presented. In the first, DNA samples from families diagnosed with hereditary disorders, which allow researchers a shot at the all-or-nothing game of finding genes, are a protected resource. In the second, the DNA reference panel of the CEPH (Centre d'Etude

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2

Bell, Jordana Tzenova. "Epistasis in complex human traits." Thesis, University of Oxford, 2006. http://ora.ox.ac.uk/objects/uuid:547db446-c84c-4a6c-8b5c-ce960f7765c5.

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3

Godley, Donnae-Maree. "Dasein online! a study of the experience of flow in the virtual playground." Thesis, Rhodes University, 2012. http://hdl.handle.net/10962/d1002492.

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The purpose of this study was twofold. First, it aimed to present and understand the experiences of online gamers from the paradigm of positive psychology. To achieve this, the phenomenon of flow was investigated to see whether or not, it is experienced whilst gaming online and if present, how it is revealed in this context. The second purpose was to contribute to theory building and to respond to extant research recommendations. Aligned with a qualitative orientation, the method selected to achieve the objectives of the study was interpretative phenomenological analysis. A sample of four part

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4

Van, der Spuy Gian Dreyer. "Analysis and application of evolutionary markers in the epidemiology of Mycobacterium tuberculosis." Thesis, Stellenbosch : Stellenbosch University, 2008. http://hdl.handle.net/10019.1/1457.

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Thesis (PhD (Biomedical Sciences. Molecular Biology and Human Genetics))--Stellenbosch University, 2008.<br>This series of studies includes both methodological analyses, aimed at furthering our understanding of, and improving the tools used in molecular epidemiology, and investigative projects which have used these tools to add to our knowledge of the M. tuberculosis epidemic. Using serial isolates from tuberculosis patients, we have investigated the evolutionary rate of the IS6110 RFLP pattern. In accordance with other studies, we determined a ½-life for this epidemiological marker of 10.6

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5

Gauthier, Isabelle. "Analyse de la norme sociale comme contrainte au consentement : l'exemple de la recherche biomédicale en situation d'urgence." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=31052.

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This thesis seeks to demonstrate, by way of a multidisciplinary study, that consent is, despite its legal definition which refers to the free and enlighted expression of individual will, in fact, at times limited if not eliminated, by social considerations, arising from the medical, economic and legal context. These considerations reflect what one might call the social norm. An appropriate understanding of consent serves, therefore, to express the social norm as a constraint, which, in turn, acts as a measure of what it means to belong in society. Thus, while consent is often presented as the

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6

Bekele, Adane Mihret. "Gene expression and cytokine pattern of pulmonary tuberculosis patients and their contacts in Ethiopia." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/71942.

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Thesis (PhD)--Stellenbosch University, 2013.<br>ENGLISH ABSTRACT: The immune response against M. tuberculosis is multifactorial, involving a network of innate and adaptive immune responses. Characterization of the immune response, a clear understanding of the dynamics and interplay of different arms of the immune response and the identification of infection-stage specific biomarkers are critical to allow the development of better tools for combating tuberculosis. In an attempt to identify such biomarkers, we studied pulmonary tuberculosis patients and their contacts in Addis Ababa, Ethio

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Khayundi, Francis Mapati Bulimo. "The effects of climate change on the realisation of the right to adequate food in Kenya." Thesis, Rhodes University, 2012. http://hdl.handle.net/10962/d1003190.

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This thesis examines the interplay between the effects of climate change and human rights. It seeks to interrogate the contribution of human rights in addressing the effects of climate change on the enjoyment of the right to food in Kenya. Climate change has been recognised as a human rights issue. Despite this acknowledgement, many states are yet to deal with climate change as a growing threat to the realisation of human rights. The situation is made worse by the glacial pace in securing a binding legal agreement to tackle climate change. The thesis also reveals that despite their seemingly d

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8

Yako, Yandiswa Yolanda. "Molecular investigation of genetic and environmental factors contributing to obesity in adolescent learners residing in the semi-urban/rural areas of the Western Cape Province, South Africa." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/71644.

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Thesis (PhD)--Stellenbosch University, 2012.<br>Includes bibliography<br>ENGLISH ABSTRACT: Background/Aims: Obesity has increased rapidly in South African children and adolescents with significant variability observed among racial groups. Genes that regulate appetite have been studied in different populations worldwide, but their role in obesity among South African adolescents is unknown. The present study aimed at investigating the role of these genes, and their combined effect with physical activity in the development of obesity among South African adolescents. Methods: A total of 1564

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9

Karlsson, Stefan. "A Norm Creative Perspective : Understanding users through norm creative theories." Thesis, Umeå universitet, Institutionen för informatik, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-154776.

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There is a saying that we should not attempt to fix what is not broken, but we cannot afford to stick tothat mindset if we want to be able to design products and services that matter to the user. We shouldbroaden our views, explore new things and see what we can learn from them and use that knowledge toexpand on our existing methods. In recent years there have been a lot of work regarding how normsinfluence us to act and feel in certain ways, what if the knowledge behind norms could be utilized withindesign? To answer this question a study was conducted where two so called norm creative method

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10

Bilginer, Onur. "Control And Manipulation Of Life: A Critical Assessment Of Genetics Through The Perspectives Of Hans Jonas, Martin Heidegger And Michel Foucault." Master's thesis, METU, 2006. http://etd.lib.metu.edu.tr/upload/12607453/index.pdf.

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This study is on the political and ethical aspects of recent advances in genetics. Its aim is to explicate the scientific and technological premises of genetics along historical, philosophical and political axes by employing the critical perspectives of Jonas, Heidegger and Foucault. Starting the discussion from a brief account of scientific and technological revolutions initiated in the 16th and 17th centuries, I defend the thesis that the idea of control and manipulation of life is not a novelty introduced by genetics, but a historical orientation underlying modern man&rsquo<br>s metaphysica

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11

Ferreira, Mariana Toledo. "A institucionalização da pesquisa em genética no Brasil e seus pesquisadores: um estudo de caso do Centro de Estudos do Genoma Humano da USP." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/8/8132/tde-27012014-110441/.

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Partindo da concepção de que a ciência é, por definição, uma atividade coletiva, organizada localmente e através de instituições, esta dissertação realiza um estudo empírico do Centro de Estudos do Genoma Humano (CEGH), situado na Universidade de São Paulo. A pergunta mais geral do trabalho diz respeito à maneira pela qual se dá a organização social da produção de conhecimento e da produção de produtores de conhecimento em uma área específica de pesquisa a genética em um país periférico. Para isso, parte-se do processo de institucionalização da pesquisa em genética no Brasil, enfatizando os

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12

Iezzi, Valeria. "Connectedness : Designing interactive systems that foster togetherness as a form of resilience for people in social distancing during Covid-19 pandemic. Exploring novel user experiences in the intersection between light perception, tangible interactions and social interaction design (SxD)." Thesis, Malmö universitet, Malmö högskola, Institutionen för konst, kultur och kommunikation (K3), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-37697.

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This thesis project explores how interactive technologies can facilitate a sense of social connectedness with others whilst remotely located. While studying the way humans use rituals for emotional management, I focused my interest on the act of commensality because it is one of the oldest and most important rituals used to foster togetherness among families and groups of friends. Dining with people who do not belong to the same household is of course hard during a global pandemic, just like many of the other forms of social interactions that were forcibly replaced by the use of technological

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13

Leite, Marcelo. "Biologia total : hegemonia e informação no genoma humano." [s.n.], 2005. http://repositorio.unicamp.br/jspui/handle/REPOSIP/280489.

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Orientador: Laymert Garcia dos Santos<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Filosofia e Ciencias Humanas<br>Made available in DSpace on 2018-08-05T01:28:26Z (GMT). No. of bitstreams: 1 Leite_Marcelo_D.pdf: 18137235 bytes, checksum: d2ccf296709649c706ae95e568a4a4e8 (MD5) Previous issue date: 2005<br>Resumo: A tese central deste trabalho é que a aceitação pública despertada pelo Projeto Genoma Humano só se explica pelo uso político e retórico de um determinismo genético crescentemente irreconciliável com os resultados empíricos da pesquisa genômica atual. A com

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14

Kazeem, Ganiat Omolara. "Technology In Policing : An ethnographic study of the use of information and communication technology within Bedfordshire police force." Thesis, Linnéuniversitetet, Institutionen för informatik (IK), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-76419.

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Policing in The United Kingdom is an intricate business, balancing the enforcement of statute and other laws while dealing with public safety and security. Policing engages a diverse and complicated set of organisational structures and processes relying heavily on the skill and expertise of officers on the ground. Their role in preventing and or intercepting crime before, during and after it occurs is integral to sustaining peace, security, law and order in communities. The police operational and logistics staff work day to day with information and communication technologies, ranging from conv

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15

Saleh, Diana. "Interaction Design for Remote Control of Military Unmanned Ground Vehicles." Thesis, Linköpings universitet, Interaktiva och kognitiva system, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-174074.

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The fast technology development for military unmanned ground vehicles (UGVs) has led to a considerable demand to explore the soldier’s role in an interactive UGV system. This thesis explores how to design interactive systems for UGVs for infantry soldiers in the Swedish Armed Force. This was done through a user-centered design approach in three steps; (1) identifying the design drivers of the targeted military context through qualitative observations and user interviews, (2) using the design drivers to investigate concepts for controlling the UGV, and (3) create and evaluate a prototype of an

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16

Cortobius, Fredriksson Moa. "ProBenefit : Implementing the Convention on Biological Diversity in the Ecuadorian Amazon." Thesis, Södertörn University College, School of Life Sciences, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-2771.

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<p>Legislation on benefit sharing dates back to 1992 and the commandment of the UNConvention on Biological Diversity, hence implementation still has few cases to fall back on(CBD, 1992). The case study of the project ProBenefit presented by the thesis highlights howlack of deliberation can undermine a democratic process. The objective of the thesis is thatProBenefit’s attempt to implement the standards of the CBD on access and benefit sharingwill highlight not only problems met by this specific project, but difficulties that generallymeet democratic processes in contexts of high inequality. To

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17

Chen, Siying. "Integration of Functional Genomic Data in Genetic Analysis." Thesis, 2021. https://doi.org/10.7916/d8-snjy-r856.

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Identifying disease risk genes is a central topic of human genetics. Cost-effective exome and whole genome sequencing enabled large-scale discovery of genetic variations. However, the statistical power of finding new risk genes through rare genetic variation is fundamentally limited by sample sizes. As a result, we have an incomplete understanding of genetic architecture and molecular etiology of most of human conditions and diseases. In this thesis, I developed new computational methods that integrate functional genomics data sets, such as epigenomic profiles and single-cell transcriptomics,

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18

Swaminathan, Shanker. "ROLE OF GENOMIC COPY NUMBER VARIATION IN ALZHEIMER'S DISEASE AND MILD COGNITIVE IMPAIRMENT." Thesis, 2013. http://hdl.handle.net/1805/3224.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Alzheimer's disease (AD) is the most common form of dementia defined by loss in memory and cognitive abilities severe enough to interfere significantly with daily life activities. Amnestic mild cognitive impairment (MCI) is a clinical condition in which an individual has memory deficits not normal for the individual's age, but not severe enough to interfere significantly with daily functioning. Every year, approximately 10-15% of individuals with MCI will progress to dementia. Currently, there is no treatment to slow or halt AD progr

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19

Dembinski, Gina. "Evaluation of the IrisPlex DNA-based eye color prediction tool in the United States." Thesis, 2014. http://hdl.handle.net/1805/4836.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>DNA phenotyping is a rapidly developing area of research in forensic biology. Externally visible characteristics (EVCs) can be determined based on genotype data, specifically from single nucleotide polymorphisms (SNPs). These SNPs are chosen based on their association with genes related to the phenotypic expression of interest, with known examples in eye, hair, and skin color traits. DNA phenotyping has forensic importance when unknown biological samples at a crime scene do not result in a criminal database hit; a phenotype profil

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20

Kalash, Abeer. "Trust modelling through social sciences." Thesis, 2014. http://hdl.handle.net/1805/6454.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>In today's fast paced world, people have become increasingly interested in online communication to facilitate their lives and make it faster. This goes on from simple social interactions to more advanced actions like shopping on the internet. The presence of such activities makes it crucial for people to use their common sense and judgment to process all this information and evaluate what/who they trust and what/whom they do not. This process would have been much easier if the number of people in such networks is really small and man

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21

Erasmus, Louie. "Verbandlegging tussen die nasionale plan vir gesinslewe en staatsbefondsde programme van maatskaplike welsynsorganisasies." Thesis, 2012. http://hdl.handle.net/10210/7184.

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M.A.<br>The principle aim of the present study was to uncover the similarities and differences between the National Plan for Family Life (NPFL) and six state-funded programmes of social welfare organisations. A checklist was compiled from the NPFL on the basis of an explorative-descriptive research design with the following categories: "principles", "aim", "objectives", "the identified needs of families", "target groups" and "actions". The content of the said six state-funded programmes of social-welfare organisations were then analysed by means of the said checklist in order to uncover any po

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22

Lahood, Gregg. "Bearing in mind : birth, fathers, ritual, and 'reproductive consciousness' in transpersonal anthropological perspective : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Social Anthropology at Massey University, Albany, New Zealand." 2006. http://hdl.handle.net/10179/1468.

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Bearing in Mind: Birth, Fathers, Ritual, and 'Reproductive Consciousness' in Transpersonal Anthropological Perspective is an exploration of 'unusual' psychospiritual experiences among a small group of procreative fathering males in New Zealand and the viewing of these experiences through a transpersonal anthropological lens. I have used the transpersonal literature and the anthropological record, coupled with fieldwork among contemporary males to explore some of their more 'non-ordinary' responses to childbirth, paying close attention to the symbolic and therapeutic dimension implicated in the

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23

De, Beer Marlene. "The implementation of equality and elimination of discriminatory practices by police officials at station level." Thesis, 2012. http://hdl.handle.net/10210/5791.

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M.A.<br>Although all forms of apartheid control legislation have been repealed and the Constitution and Bill of Rights adopted, it is questionable in what way these principles of equality and non-discrimination are effectively implemented and whether changes have occurred in practice. Chapter one therefore provides an overview of the study. The discussion of legislation viz. the Constitution, the Equality Clause and Employment Equity Act urges the elimination of discrimination and the implementation of equality. The legacy of policing also provides the challenge to change. Several SAPS policie

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24

Markwick, Moira. "Eating as a cultural performance in early 21st century New Zealand : an exploration of the relationships between food and place : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in Social Anthropology at Massey University, Auckland, New Zealand." 2009. http://hdl.handle.net/10179/1234.

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During New Zealand’s comparatively short history as a nation, its cuisine has undergone great development. The culinary traditions brought by the early settlers, from both Eastern Polynesia and then Britain, offered a relatively limited variety, however, since the late 20th century New Zealand’s foodways have undergone a revolution; today a smorgasbord of international cuisines awaits our selection. This gastronomic range is the result of a number of factors which include the influx of diverse immigrants, increased air travel by New Zealanders, the return of military personnel from overseas an

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25

Kim, Sung-Ju. "The impact of federal government welfare expenditures on state government expenditures and philanthropic giving to human service organizations (HSOs) : 2005-2006." Thesis, 2014. http://hdl.handle.net/1805/4523.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>A sizeable body of research has attempted to examine the interaction between government spending and private giving known as the crowd-out effect. Most researchers reported that increases of government spending cause decreases of philanthropic giving to different types of nonprofits. However, few studies have attempted to indicate the interaction between government welfare expenditures and private giving to human service organizations even though human service organizations are the most sensitive to the changes of government spending

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26

Conroy, Susan Kim. "Chemotherapy, estrogen, and cognition : neuroimaging and genetic variation." Thesis, 2014. http://hdl.handle.net/1805/4027.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>The time course and biological mechanisms by which breast cancer (BC) and/or alterations in estrogen status lead to cognitive and brain changes remain unclear. The studies presented here use neuroimaging, cognitive testing, genetics, and biomarkers to investigate how post-chemotherapy interval (PCI), chemotherapy-induced amenorrhea (CIA), and genetic variation in the estrogen pathway affect the brain. Chapter 1 examines the association of post-chemotherapy interval (PCI) with gray matter density (GMD) and working memory-related brain

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27

Downing, Brandon David. "Myeloid cells induce neurofibromatosis type 1 aneurysm formation through inflammation and oxidative stress." Thesis, 2014. http://hdl.handle.net/1805/5850.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Neurofibromatosis Type 1 (NF1) is a genetic disorder resulting from mutations in the NF1 tumor suppressor gene. Neurofibromin is the protein product of NF1 and functions as a negative regulator of Ras activity in both hematopoietic and vascular wall cells, which are critical for maintaining blood vessel homeostasis. NF1 patients are predisposed to chronic inflammation and premature cardiovascular disease, including development of large arterial aneurysms, which may result in sudden death secondary to their rupture. However, the molec

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28

Khumalo, Cynthia Tuduetso. "A reflection on the group interaction and cohesion in a participatory research process :." Diss., 1999. http://hdl.handle.net/10500/17083.

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In 1995 a participatory research project was undertaken in the Gauteng Welfare Deparbnent by two outside researchers. The subject for the research was the management of change in the Gauteng Welfare Department. During the research, the researcher observed how the discouraged, apathetic and negative group became animated and empowered. On the basis of this observation, the researcher undertook to do a case study which reflects on the interactional process and cohesion which transpired within the participatory research process.<br>Social Science<br>M.A. Social Science (Mental Health)

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29

Schenck, Catherina Johanna. "Paradigma ontleding van en paradigma beskrywing vir deelnemende werkswyses." 1998. http://hdl.handle.net/10500/17673.

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Community development and in particular participatory development is about people. This means that the person who studies or practices participatory development or any other of the participatory pratices should have a particular way of thinking about people. The main aim motivating this study was to investigate the paradigm/s about people on which participatory practices are based. This included a literature research on five participatory practices namely participatory development; participatory communication; participatory learning; participatory research; and participatory managem

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30

Li, Li. "Spatio-temporal analyses of the distribution of alcohol outlets in California." Thesis, 2014. http://hdl.handle.net/1805/6463.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>The objective of this research is to examine the development of the California alcohol outlets over time and the relationship between neighborhood characteristics and densities of the alcohol outlets. Two types of advanced analyses were done after the usual preliminary description of data. Firstly, fixed and random effects linear regression were used for the county panel data across time (1945-2010) with a dummy variable added to capture the change in law regarding limitations on alcohol outlets density. Secondly, a Bayesian spatio-t

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31

Sethuntsa, Molelekeng. "The development of a therapeutic approach for the treatment of individuals with Prader-Willi syndrome and their primary caregivers." Thesis, 2017. http://hdl.handle.net/10500/23826.

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Prader-Willi syndrome (PWS) is a genetic disorder resulting from a mutation of chromosome 15. It can manifest in physiological characteristics, cognitive impairment, behavioural problems, and sometimes also psychiatric disturbances. Taking care of an individual with PWS has a detrimental impact on the primary caregiver and also affects others around them. This considered, the current study aimed to learn more about the experiences and challenges of individuals diagnosed with PWS and their primary caregivers, in Gauteng and North-West Provinces, South Africa. Purposive sampling was used to sele

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Mokwatlo, Elizabeth Maboakae. "The evaluation of the implementation of HIV-AIDS policies at school level with particular focus on discrimination and stigma amongst educators." Diss., 2006. http://hdl.handle.net/10500/2085.

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Against the background of evidence that HIV-AIDS has had and continues to have an enormous impact on all South African schools, a need has arisen for HIV -AIDS policies and programmes to be effectively implemented in all schools. In this study, a qualitative methodology was used to evaluate policy implementation in the North West province. Data was gathered by means of field notes, observation and interviews with management and educators. The study found that although principals and educators are knowledgeable about HIV -AIDS, there is a tendency to discriminate against infected educato

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