Relevant bibliographies by topics / Human Induced neurons

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Human Induced neurons'

Author: Grafiati
Published: 15 June 2024
Last updated: 31 July 2025

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Journal articles on the topic "Human Induced neurons"

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Wang, Gefei, Rui Li, Zhiwu Jiang, et al. "Influenza Virus Induces Inflammatory Response in Mouse Primary Cortical Neurons with Limited Viral Replication." BioMed Research International 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/8076989.

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Unlike stereotypical neurotropic viruses, influenza A viruses have been detected in the brain tissues of human and animal models. To investigate the interaction between neurons and influenza A viruses, mouse cortical neurons were isolated, infected with human H1N1 influenza virus, and then examined for the production of various inflammatory molecules involved in immune response. We found that replication of the influenza virus in neurons was limited, although early viral transcription was not affected. Virus-induced neuron viability decreased at 6 h postinfection (p.i.) but increased at 24 h p
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Häkli, Martta, Satu Jäntti, Tiina Joki, et al. "Human Neurons Form Axon-Mediated Functional Connections with Human Cardiomyocytes in Compartmentalized Microfluidic Chip." International Journal of Molecular Sciences 23, no. 6 (2022): 3148. http://dx.doi.org/10.3390/ijms23063148.

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The cardiac autonomic nervous system (cANS) regulates cardiac function by innervating cardiac tissue with axons, and cardiomyocytes (CMs) and neurons undergo comaturation during the heart innervation in embryogenesis. As cANS is essential for cardiac function, its dysfunctions might be fatal; therefore, cardiac innervation models for studying embryogenesis, cardiac diseases, and drug screening are needed. However, previously reported neuron-cardiomyocyte (CM) coculture chips lack studies of functional neuron–CM interactions with completely human-based cell models. Here, we present a novel comp
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Rawson, N. E., G. Gomez, B. Cowart, et al. "Selectivity and Response Characteristics of Human Olfactory Neurons." Journal of Neurophysiology 77, no. 3 (1997): 1606–13. http://dx.doi.org/10.1152/jn.1997.77.3.1606.

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Rawson, N. E., G. Gomez, B. Cowart, J. G. Brand, L. D. Lowry, E. A. Pribitkin, and D. Restrepo. Selectivity and response characteristics of human olfactory neurons. J. Neurophysiol. 77: 1606–1613, 1997. Transduction mechanisms were investigated in human olfactory neurons by determining characteristics of odorant-induced changes in intracellular calcium concentration ([Ca2+]i). Olfactory neurons were freshly isolated from nasal biopsies, allowed to attach to coverslips, and loaded with the calcium-sensitive indicator fura-2. Changes in [Ca2+]i were studied in response to exposure to individual
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Kraskovskaya, Nina, Anastasia Bolshakova, Mikhail Khotin, Ilya Bezprozvanny, and Natalia Mikhailova. "Protocol Optimization for Direct Reprogramming of Primary Human Fibroblast into Induced Striatal Neurons." International Journal of Molecular Sciences 24, no. 7 (2023): 6799. http://dx.doi.org/10.3390/ijms24076799.

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The modeling of neuropathology on induced neurons obtained by cell reprogramming technologies can fill a gap between clinical trials and studies on model organisms for the development of treatment strategies for neurodegenerative diseases. Patient-specific models based on patients’ cells play an important role in such studies. There are two ways to obtain induced neuronal cells. One is based on induced pluripotent stem cells. The other is based on direct reprogramming, which allows us to obtain mature neuronal cells from adult somatic cells, such as dermal fibroblasts. Moreover, the latter met
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Gunewardene, Niliksha, Duncan Crombie, Mirella Dottori, and Bryony A. Nayagam. "Innervation of Cochlear Hair Cells by Human Induced Pluripotent Stem Cell-Derived NeuronsIn Vitro." Stem Cells International 2016 (2016): 1–10. http://dx.doi.org/10.1155/2016/1781202.

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Induced pluripotent stem cells (iPSCs) may serve as an autologous source of replacement neurons in the injured cochlea, if they can be successfully differentiated and reconnected with residual elements in the damaged auditory system. Here, we explored the potential of hiPSC-derived neurons to innervate early postnatal hair cells, using establishedin vitroassays. We compared two hiPSC lines against a well-characterized hESC line. After ten days’ coculturein vitro, hiPSC-derived neural processes contacted inner and outer hair cells in whole cochlear explant cultures. Neural processes from hiPSC-
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Perego, M. Chiara, Benjamin D. McMichael, Nicholas R. McMurry, Scott W. Ventrello, and Lisa J. Bain. "Arsenic Impairs Differentiation of Human Induced Pluripotent Stem Cells into Cholinergic Motor Neurons." Toxics 11, no. 8 (2023): 644. http://dx.doi.org/10.3390/toxics11080644.

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Arsenic exposure during embryogenesis can lead to improper neurodevelopment and changes in locomotor activity. Additionally, in vitro studies have shown that arsenic inhibits the differentiation of sensory neurons and skeletal muscle. In the current study, human-induced pluripotent stem (iPS) cells were differentiated into motor neurons over 28 days, while being exposed to up to 0.5 μM arsenic. On day 6, neuroepithelial progenitor cells (NEPs) exposed to arsenic had reduced transcript levels of the neural progenitor/stem cell marker nestin (NES) and neuroepithelial progenitor marker SOX1, whil
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Cheng, Xueyan, Zijian Tan, Xiao Huang, et al. "Inhibition of Glioma Development by ASCL1-Mediated Direct Neuronal Reprogramming." Cells 8, no. 6 (2019): 571. http://dx.doi.org/10.3390/cells8060571.

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Direct conversion of non-neural cells into induced neurons holds great promise for brain repair. As the most common malignant tumor in the central nervous system, glioma is currently incurable due to its exponential growth and invasive behavior. Given that neurons are irreversible postmitotic cells, reprogramming glioma cells into terminally differentiated neuron-like cells represents a potential approach to inhibit brain tumor development. We here show that human glioma cells can be directly, rapidly and efficiently reprogrammed into terminally differentiated neuron-like cells by the single t
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Karpe, Yashashree, Zhenyu Chen, and Xue-Jun Li. "Stem Cell Models and Gene Targeting for Human Motor Neuron Diseases." Pharmaceuticals 14, no. 6 (2021): 565. http://dx.doi.org/10.3390/ph14060565.

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Motor neurons are large projection neurons classified into upper and lower motor neurons responsible for controlling the movement of muscles. Degeneration of motor neurons results in progressive muscle weakness, which underlies several debilitating neurological disorders including amyotrophic lateral sclerosis (ALS), hereditary spastic paraplegias (HSP), and spinal muscular atrophy (SMA). With the development of induced pluripotent stem cell (iPSC) technology, human iPSCs can be derived from patients and further differentiated into motor neurons. Motor neuron disease models can also be generat
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Tian, Jie L., Chia-Wei Huang, Farzad Eslami, Michael Philip Mannino, Rebecca Lee Mai, and Gerald W. Hart. "Regulation of Primary Cilium Length by O-GlcNAc during Neuronal Development in a Human Neuron Model." Cells 12, no. 11 (2023): 1520. http://dx.doi.org/10.3390/cells12111520.

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The primary cilium plays critical roles in the homeostasis and development of neurons. Recent studies demonstrate that cilium length is regulated by the metabolic state of cells, as dictated by processes such as glucose flux and O-GlcNAcylation (OGN). The study of cilium length regulation during neuron development, however, has been an area left largely unexplored. This project aims to elucidate the roles of O-GlcNAc in neuronal development through its regulation of the primary cilium. Here, we present findings suggesting that OGN levels negatively regulate cilium length on differentiated cort
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McDonald, Kirstin O., Nikita M. A. Lyons, Luca K. C. Gray, et al. "Transcription Factor-Mediated Generation of Dopaminergic Neurons from Human iPSCs—A Comparison of Methods." Cells 13, no. 12 (2024): 1016. http://dx.doi.org/10.3390/cells13121016.

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Dopaminergic neurons are the predominant brain cells affected in Parkinson’s disease. With the limited availability of live human brain dopaminergic neurons to study pathological mechanisms of Parkinson’s disease, dopaminergic neurons have been generated from human-skin-cell-derived induced pluripotent stem cells. Originally, induced pluripotent stem-cell-derived dopaminergic neurons were generated using small molecules. These neurons took more than two months to mature. However, the transcription-factor-mediated differentiation of induced pluripotent stem cells has revealed quicker and cheape
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Dissertations / Theses on the topic "Human Induced neurons"

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Melo, de Farias Ana Raquel. "Probing the Alzheimer’s disease risk gene PTK2B using human-derived induced neurons." Electronic Thesis or Diss., Université de Lille (2022-....), 2023. http://www.theses.fr/2023ULILS062.

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La maladie d'Alzheimer (MA) est le principal type de démence et représente un défi majeur pour la santé publique mondiale. Elle se caractérise par un déclin progressif de la cognition, de la mémoire et des fonctions comportementales et touche plus de 55 millions de personnes dans le monde. Au niveau moléculaire, la MA se définit par la présence d'enchevêtrements neurofibrillaires agrégés dans les neurones et par l'accumulation de plaques d'amyloïde-β (Aβ) dans le cerveau. Ces caractéristiques pathologiques sont associées à des altérations de l'activité neuronale, à la perte de synapses, à la g
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Sánchez, Danés Adriana 1984. "Generation of human dopaminergic neurons from induced pluripotent stem cells to model Parkinson's disease." Doctoral thesis, Universitat Pompeu Fabra, 2012. http://hdl.handle.net/10803/96912.

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Parkinson’s disease (PD) is an incurable, chronically progressive neurodegenerative disease leading to premature invalidity and death. The locomotor disability of PD patients is mainly rooted in the gradual and insidious degeneration of dopaminergic neurons (DA) projecting from the midbrain substantia nigra (SN) to the basal ganglia striatum, a pathological process highlighted microscopically by the formation of insoluble cytosolic protein aggregates, known as Lewy bodies and Lewy neurites. The pathogenic mechanisms leading to PD remain poorly understood, arguably owing to the lack of suitable
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GIANI, ALICE MARIA. "GENERATION OF AUTHENTIC HUMAN NEOCORTICAL NEURONS FROM INDUCED PLURIPOTENT STEM CELLS TO INVESTIGATE 7Q11.23 GENE DOSAGE IMBALANCES." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/561835.

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Questo lavoro di tesi ha avuto lo scopo di studiare lo sviluppo della neocorteccia umana ed i meccanisimi alla base della sua compromissione che risultano nell’insorgenza di patologie del neurosviluppo mediante un’analisi dei profili trascrizionali e della morfologia di neuroni neocorticali umani generati a partire da cellule staminali pluripotenti indotte (iPSCs). Data l’importanza di basarsi su un paradigma di neurogenesi in vitro riproducibile e affidabile nel generare neuroni neocoritcali umani autentici, prima di adottare questo sistema modello per lo studio di patologie del neurosvilup
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Fenske, Pascal [Verfasser]. "Characterization of synaptic transmission in autaptic cultured neurons derived from human induced pluripotent stem cells / Pascal Fenske." Berlin : Freie Universität Berlin, 2021. http://d-nb.info/1234451611/34.

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Toli, Diana Eleni. "Directed differentiation and purification of motor neurons from human induced pluripotent stem cells to model Amyotrophic Lateral Sclerosis." Thesis, Paris 5, 2013. http://www.theses.fr/2013PA05T044/document.

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La sclérose latérale amyotrophique (SLA) est une maladie neurodégénérative incurable de l’adulte qui affecte principalement les motoneurones. Les mécanismes conduisant à la mort des motoneurones restent mal connus, notamment du fait de l'hétérogénéité de la maladie et du manque d'accès aux neurones humains affectés. La technologie des cellules souches pluripotentes induites humaines (iPSc) est un outil prometteur pour la modélisation de la SLA, car elle offre la possibilité unique d'obtenir et d’étudier des motoneurones humains.Des clones d’iPSc de deux sujets témoins ont été générés et nous a
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Hermann, Andreas, Jeong Beom Kim, Sumitra Srimasorn, et al. "Factor-Reduced Human Induced Pluripotent Stem Cells Efficiently Differentiate into Neurons Independent of the Number of Reprogramming Factors." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-203366.

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Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) by overexpression of the transcription factors OCT4, SOX2, KLF4, and c-Myc holds great promise for the development of personalized cell replacement therapies. In an attempt to minimize the risk of chromosomal disruption and to simplify reprogramming, several studies demonstrated that a reduced set of reprogramming factors is sufficient to generate iPSC. We recently showed that a reduction of reprogramming factors in murine cells not only reduces reprogramming efficiency but also may worsen subsequent differentiation. To
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Miyawaki, Yoshifumi. "Zonisamide promotes survival of human induced pluripotent stem cell-derived dopaminergic neurons in the striatum of female rats." Kyoto University, 2020. http://hdl.handle.net/2433/259730.

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Beevers, Joel Edward. "Investigating the function of microtubule-associated protein tau (MAPT) and its genetic association with Parkinson's using human iPSC-derived dopamine neurons." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:7a94919a-73a1-4a9f-b04d-cdf5b9c64be7.

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Parkinson's disease (PD) primarily manifests as loss of motor control through the degeneration of nigrostriatal dopaminergic neurons. The microtubule-associated protein tau (MAPT) locus is highly genetically associated with PD, wherein the H1 haplotype confers disease risk and the H2 haplotype is protective. As this haplotype variation does not alter the amino acid sequence, disease risk may be conferred by altered gene expression, either of total MAPT or of specific isoforms, of which there are six in adult human brain. To investigate haplotype-specific control of MAPT expression in the neuro
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Burton, Mark P., Declan J. McKeefry, Brendan T. Barrett, Chara Vakrou, and A. B. Morland. "Disruptions to human speed perception induced by motion adaptation and transcranial magnetic stimulation." Wiley, 2009. http://hdl.handle.net/10454/4731.

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no<br>To investigate the underlying nature of the effects of transcranial magnetic stimulation (TMS) on speed perception, we applied repetitive TMS (rTMS) to human V5/MT+ following adaptation to either fast- (20 deg/s) or slow (4 deg/s)-moving grating stimuli. The adapting stimuli induced changes in the perceived speed of a standard reference stimulus moving at 10 deg/s. In the absence of rTMS, adaptation to the slower stimulus led to an increase in perceived speed of the reference, whilst adaptation to the faster stimulus produced a reduction in perceived speed. These induced changes in speed
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Kikuchi, Tetsuhiro. "Survival of human induced pluripotent stem cell-derived midbrain dopaminergic neurons in the brain of a primate model of Parkinson's disease." Kyoto University, 2012. http://hdl.handle.net/2433/159389.

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Books on the topic "Human Induced neurons"

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Nat, Roxana, and Andreas Eigentler. Cell Culture, iPS Cells and Neurodegenerative Diseases. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190233563.003.0013.

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Somatic reprogramming technology, which enables the conversion of adult human non-neural cells into neurons, has progressed rapidly in recent years. The derivation of patient-specific induced pluripotent stem (iPS) cells has become routine. The inherent broad differentiation potential of iPS cells makes possible the generation of diverse types of human neurons. This constitutes a remarkable step in facilitating the development of more appropriate and comprehensive preclinical human disease models, as well as for high throughput drug screenings and cell therapy. This chapter reviews recent prog
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Seth, Rohit. Zinc deficiency induces apoptosis via mitochondrial p53- and caspase-dependent pathways in human neuronal precursor cells. Elseveir, 2014.

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Bisschops, Raf. Ligand & Electrically Induced Activation Patterns in Myenteric Neuronal Networks: Confocal Calcium Imaging As a Bridge Between Basic & Human Physiology (Acta Biomedica Lovaniensia). Leuven Univ Pr, 2005.

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Ziemann, Ulf. Pharmacology of TMS measures. Edited by Charles M. Epstein, Eric M. Wassermann, and Ulf Ziemann. Oxford University Press, 2012. http://dx.doi.org/10.1093/oxfordhb/9780198568926.013.0013.

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This article discusses various aspects of the pharmacology of transcranial magnetic stimulator (TMS) measures. TMS measures reflect axonal, or excitatory or inhibitory synaptic excitability in distinct interneuron circuits. TMS measures can be employed to study the effects of a drug with unknown or multiple modes of action, and hence to determine its main mode of action at the systems level of the motor cortex. TMS experiments can also study acute drug effects that may be different from chronic drug effects. TMS or repetitive TMS may induce changes in endogenous neurotransmitter or neuromodula
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Book chapters on the topic "Human Induced neurons"

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Zhou-Yang, Lucia, Sophie Eichhorner, Lukas Karbacher, Lena Böhnke, Larissa Traxler, and Jerome Mertens. "Direct Conversion of Human Fibroblasts to Induced Neurons." In Methods in Molecular Biology. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1601-7_6.

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Legault, Emilie M., and Janelle Drouin-Ouellet. "Generation of Induced Dopaminergic Neurons from Human Fetal Fibroblasts." In Methods in Molecular Biology. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1601-7_7.

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Tofoli, Fabiano Araújo, Ana Teresa Silva Semeano, Ágatha Oliveira-Giacomelli, et al. "Midbrain Dopaminergic Neurons Differentiated from Human-Induced Pluripotent Stem Cells." In Methods in Molecular Biology. Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9007-8_8.

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Rizalar, Filiz Sila, and Volker Haucke. "Generation of Glutamatergic Human Neurons from Induced Pluripotent Stem Cells." In Methods in Molecular Biology. Springer US, 2025. https://doi.org/10.1007/978-1-0716-4446-1_2.

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Garg, Pretty, Mathias Bähr, and Sebastian Kügler. "Differentiation of Mature Dopaminergic Neurons from Human Induced Pluripotent Stem Cells." In Methods in Molecular Biology. Springer US, 2025. https://doi.org/10.1007/978-1-0716-4446-1_4.

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Fernandes, Sofia R., Mariana Pereira, Sherif M. Elbasiouny, Yasin Y. Dhaher, Mamede de Carvalho, and Pedro C. Miranda. "Interplay Between Electrical Conductivity of Tissues and Position of Electrodes in Transcutaneous Spinal Direct Current Stimulation (tsDCS)." In Brain and Human Body Modelling 2021. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-15451-5_7.

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AbstractTranscutaneous Spinal Direct Current Stimulation (tsDCS) is a neuromodulatory technique that applies low intensity (2–4 mA) direct currents to the spinal cord through electrodes placed above or near the vertebral column. As in transcranial electric stimulation, tsDCS induces an electric field in the spinal cord that can transiently change the transmembrane potential of spinal neurons or influence synaptic communication. Anatomical features near the electrodes or in the current path can originate local variations of the electric field magnitude and orientation that result in different e
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Lopes, Carla. "Imaging Mitochondrial Axonal Transport in Human Induced Pluripotent Stem Cell-Derived Neurons." In Methods in Molecular Biology. Springer US, 2024. http://dx.doi.org/10.1007/978-1-0716-4264-1_10.

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Falco, Amel, Rocío Bartolomé-Cabrero, and Sergio Gascón. "Bcl-2-Assisted Reprogramming of Mouse Astrocytes and Human Fibroblasts into Induced Neurons." In Methods in Molecular Biology. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1601-7_5.

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Sepehrimanesh, Masood, and Baojin Ding. "Generation of Motor Neurons from Human Induced Pluripotent Stem Cells Using Small Chemical Molecules." In Neuromethods. Springer US, 2024. http://dx.doi.org/10.1007/978-1-0716-3999-3_11.

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Silva, M. Catarina, Ghata Nandi, and Stephen J. Haggarty. "Differentiation of Human Induced Pluripotent Stem Cells into Cortical Neurons to Advance Precision Medicine." In Methods in Molecular Biology. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-1979-7_10.

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Conference papers on the topic "Human Induced neurons"

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Schmieder, F., R. Habibey, V. Busskamp, J. W. Czarske, and L. Büttner. "Adaptive Holographic Optogenetic Illumination for Human Neural Network Analysis." In Digital Holography and Three-Dimensional Imaging. Optica Publishing Group, 2022. http://dx.doi.org/10.1364/dh.2022.w4a.7.

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A two-wavelength optogenetic stimulation platform with high spatiotemporal resolution and inherent aberration correction is presented. By stimulating single neurons, we investigated the temporal evolution of connectivity in human induced pluripotent stem cell-derived neuronal networks in-vitro.
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Pitta, Marina Galdino da Rocha, Jordy Silva de Carvalho, Luzilene Pereira de Lima, and Ivan da Rocha Pitta. "iPSC therapies applied to rehabilitation in parkinson’s disease." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.022.

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Background: Parkinson’s disease (PD) is a neurological disorder that affects movement, mainly due to damage and degeneration of the nigrostriatal dopaminergic pathway. The diagnosis is made through a clinical neurological analysis where motor characteristics are considered. There is still no cure, and treatment strategies are focused on symptoms control. Cell replacement therapies emerge as an alternative. Objective: This review focused on current techniques of induced pluripotent stem cells (iPSCs). Methods: The search terms used were: “Parkinson’s Disease”, “Stem cells” and “iPSC”. Open arti
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Murata, Masaaki, Hidekatsu Ito, Teppei Taenaka, and Suguru N. Kudoh. "Modification of activity pattern induced by synaptic enhancements in a semi-artificial network of living neurons." In 2011 International Symposium on Micro-NanoMechatronics and Human Science (MHS). IEEE, 2011. http://dx.doi.org/10.1109/mhs.2011.6102187.

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Komatsu, Masaaki, Heather E. Wheeler, Claudia Wing, Shannon Delaney, and M. Eileen Dolan. "Abstract 3489: A novel investigation into chemotherapy-induced peripheral neuropathy using iPSC-derived human neurons." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-3489.

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Ferreira, João, Manuel de Sousa Ribeiro, Ricardo Gonçalves, and João Leite. "Looking Inside the Black-Box: Logic-based Explanations for Neural Networks." In 19th International Conference on Principles of Knowledge Representation and Reasoning {KR-2022}. International Joint Conferences on Artificial Intelligence Organization, 2022. http://dx.doi.org/10.24963/kr.2022/45.

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Deep neural network-based methods have recently enjoyed great popularity due to their effectiveness in solving difficult tasks. Requiring minimal human effort, they have turned into an almost ubiquitous solution in multiple domains. However, due to the size and complexity of typical neural network models' architectures, as well as the sub-symbolical nature of the representations generated by their neuronal activations, neural networks are essentially opaque, making it nearly impossible to explain to humans the reasoning behind their decisions. We address this issue by developing a procedure to
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Foisset, F., C. Lehalle, A. Nasri, et al. "Development of a bronchial epithelium model innervated by sensory neurons from human induced pluripotent stem cells." In ERS International Congress 2022 abstracts. European Respiratory Society, 2022. http://dx.doi.org/10.1183/13993003.congress-2022.2394.

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Courellis, Hristos, Juri Minxha, Araceli Cardenas, et al. "Abstract representations encoded by human hippocampal neurons support behavioral inference and can be induced through verbal instruction." In 2023 Conference on Cognitive Computational Neuroscience. Cognitive Computational Neuroscience, 2023. http://dx.doi.org/10.32470/ccn.2023.1668-0.

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Cotter, Laurent, Romane A. Lahaye, Wei Chou Tseng, et al. "I07 Selective lowering of mutant-huntingtin by antisense oligonucleotides (ASOs) in human cortical neurons derived from patient-specific induced pluripotent stem cells (HD-IPSC)." In EHDN 2022 Plenary Meeting, Bologna, Italy, Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/jnnp-2022-ehdn.233.

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"Human induced stem cells (hiPSCs)-derived motor neurons model applied for the study of the aryl hydrocarbon receptor mediated signaling by the induction of environmental pollutant." In INTERNATIONAL CONFERENCE ON BIOLOGICAL RESEARCH AND APPLIED SCIENCE. Jinnah University for Women, 2024. http://dx.doi.org/10.37962/ibras/2024/57.

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Martens, William L., Philip Poronnik, and Darren Saunders. "Hypothesis-Driven Sonification of Proteomic Data Distributions Indicating Neurodegredation in Amyotrophic Lateral Sclerosis." In The 22nd International Conference on Auditory Display. The International Community for Auditory Display, 2016. http://dx.doi.org/10.21785/icad2016.024.

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Three alternative sonifications of proteomic data distributions were compared as a means to indicate the neuropathology associated with Amyotrophic Lateral Sclerosis (ALS) via auditory display (through exploration of the differentiation of induced pluripotent stem cell derived neurons). Pure visual displays of proteomic data often result in ”visual overload” such that detailed or subtle data important to describe ALS neurodegradation may be glossed over, and so three competing approaches to the sonification of proteomic data were designed to capitalize upon human auditory capacities that compl
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Reports on the topic "Human Induced neurons"

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Yu, Mei, Pengyu Wang, Binbin Li, et al. NRSF Negatively Regulates Microglial Pro-Inflammatory Activation. Progress in Neurobiology, 2024. http://dx.doi.org/10.60124/j.pneuro.2024.20.02.

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Microglial activation contributes to neurological disorders like Parkinson’s disease (PD), and modulating this activation is a potential therapeutic approach. The neuron-restrictive silencer factor (NRSF) functions as a negative regulator of gene transcription through epigenetic modifications. While previous research has primarily examined the role of NRSF in neuronal differentiation and injury, emerging evidence indicates that NRSF also plays a significant role in maintaining the phenotype of glial cells. In this study, we explored the role and underlying mechanisms of NRSF in lipopolysacchar
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Cheepsunthorn, Poonlarp, and Yong Poovorawan. Identification of receptors for H5N1 virus on human nerve cells using protromics-based approaches. Chulalongkorn University, 2013. https://doi.org/10.58837/chula.res.2013.12.

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Abstract:
In this study, we investigated neuroinfectious capacity of H5N1 (A/Thailand/NK165/2005) isolated from plasma of infected individual during the third wave of Thailand outbreaks using human neuroblastoma SH-SY5Y cells. This was due to lack of information regarding neuroinfectivity of this variant. Results demonstrated that H5N1/NK165 induced servere CPEs in these neuronal cells. H5N1-specific hemagglutinin was found in the cytoplasm of the infected cells as early as 12 h post-infection. By 24 h post-infection, all cells in the cultures were infected. These findings coincided with time course of
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