Log in

Relevant bibliographies by topics / Human insulin / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Human insulin.

Dissertations / Theses on the topic 'Human insulin'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Human insulin.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Karlsson, Håkan K. R. "Insulin signaling and glucose transport in insulin resistant human skeletal muscle /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-469-4/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Krook, Anna Christina. "Insulin receptor mutations in human disease." Thesis, University of Cambridge, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266558.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Argyraki, M. "Studies of insulin action in human muscle." Thesis, University of Newcastle Upon Tyne, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234398.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Hurel, Steven J. "Insulin action in cultured human skeletal muscle." Thesis, University of Newcastle Upon Tyne, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363891.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Danielsson, Anna. "Insulin signalling in human adipocytes : mechanisms of insulin resistance in type 2 diabetes." Doctoral thesis, Linköping : Univ, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-10327.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

El, Bilali Jason. "Effects of Chronic Insulin and High Glucose on Insulin-Stimulated Responses in Human Preadipocytes." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34109.

Full text

Abstract:

The preadipocyte is crucial for healthy adipose tissue (AT) remodeling, and insulin resistance in these cells may contribute to AT dysfunction. Chronic exposure to insulin and high glucose induces insulin resistance in the 3T3-L1 mouse adipocyte cell line in vitro, however, whether this occurs in human preadipocytes is not known. To investigate this, human preadipocytes were isolated from subcutaneous AT obtained from 6 female patients undergoing elective surgery (Research Ethics Board-approved). Human preadipocytes were incubated in 5 mM glucose or 25 mM glucose in the presence or absence of

APA, Harvard, Vancouver, ISO, and other styles

7

Humphreys, P. "Biochemical and genetic studies of human insulin resistance." Thesis, University of Cambridge, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604777.

Full text

Abstract:

Biochemical characterisation of fibroblasts from patients with one sub-type of severe insulin resistance, pseudo-acromegalic insulin resistance, was undertaken in order to localise the site of defective insulin signalling. The studies which were carried out can be divided into 1) verification of normal insulin receptor function 2) measurement of metabolic and mitogenic end-point actions of insulin and 3) analysis of components of the signalling cascade. In brief, in most studies the response in patient cells was indistinguishable from normal controls. However, in patient cells there was reduce

APA, Harvard, Vancouver, ISO, and other styles

8

Pickersgill, Laura. "Lipid-induced insulin resistance in human skeletal muscle." Thesis, University of Newcastle Upon Tyne, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413955.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Boyd, Alison Catherine. "Clinical and experimental studies on glycated human insulin." Thesis, University of Ulster, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390153.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Humphreys, Phillippa. "Genetic and biochemical studies of human insulin resistance." Thesis, University of Cambridge, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264507.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

McCrimmon, Rory John. "Human information processing during acute insulin-induced hypoglycaemia." Thesis, University of Edinburgh, 1999. http://hdl.handle.net/1842/22465.

Full text

Abstract:

The research described in this thesis includes studies involving experimentally induced hypoglycaemia, and a clinical study of children with insulin-dependent diabetes mellitus. The effect of acute insulin-induced hypoglycaemia on basic sensory information processing was examined. The principal studies performed were: <i>Study 1</i> - an examination of the effect of acute hypoglycaemia on visual information processing, and; <i>Study 2</i> - an examination of the effect of acute hypoglycaemia on auditory information processing. During 60 minutes of exposure to moderate hypoglycaemia significant

APA, Harvard, Vancouver, ISO, and other styles

12

Luo, Robert Zhao-Tian. "Structure and function of the human insulin receptor, quaternary 3D reconstruction of the insulin-insulin receptor complex and the structural localization of the insulin-binding site." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0019/NQ53809.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Karlsson, Margareta. "Caveolae in insulin signalling in human and rat adipocytes /." Linköping : Univ, 2003. http://www.bibl.liu.se/liupubl/disp/disp2003/med782s.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Brännmark, Cecilia. "Insulin Signaling in Human Adipocytes a Systems Biology Approach." Doctoral thesis, Linköpings universitet, Cellbiologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-85001.

Full text

Abstract:

Obesity and a sedentary life style are associated with type 2 diabetes, a disease starting with insulin resistance in the adipose tissue, which spreads to the whole body. Despite large research efforts to understand the insulin signaling system, there is little knowledge of the mechanisms behind insulin resistance and type 2 diabetes developments. We have herein focused on the insulin signaling in adipocytes, elucidating mechanisms for early signaling. We have also modeled isolated adipocytes and data from the in vivo, whole bodysituation, concurrently. We also mapped and quantitatively descri

APA, Harvard, Vancouver, ISO, and other styles

15

Au, S. T. B. "Determinants and consequences of insulin resistance in human disease." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.479276.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Bell, Andrea Dorothy Lee. "Insulin and TSH signal transduction pathways in human preadipocytes." Thesis, University of Ottawa (Canada), 2000. http://hdl.handle.net/10393/8646.

Full text

Abstract:

Signaling through the rapamycin-sensitive mammalian target of rapamycin-p70 S6 kinase (p70 S6K) pathway was examined in human preadipocytes in primary culture. The inhibitory effect of rapamycin on insulin-induced differentiation of preadipose cell lines has been attributed to a blockade of clonal expansion. We demonstrate that rapamycin inhibits the differentiation of human preadipocytes in primary culture, even though these cells do not undergo clonal expansion. Glycerol-3-phosphate-dehydrogenase (GPDH) activity, an indicator of differentiation, was reduced in omental and subcutaneous preadi

APA, Harvard, Vancouver, ISO, and other styles

17

Bell, Andrea. "Insulin and TSH signal transduction pathways in human preadipocytes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0020/MQ57086.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Soos, M. A. "Studies with monoclonal antibodies to the human insulin receptor." Thesis, University of Cambridge, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373704.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Norton, Luke. "Calpain-10 and insulin resistance in human skeletal muscle." Thesis, University of Nottingham, 2007. http://eprints.nottingham.ac.uk/11536/.

Full text

Abstract:

Variation in the calpain-10 gene has been linked to a three-fold increased risk for type 2 diabetes in Pima Indian and some European populations. Furthermore, reduced skeletal muscle expression of calpain-10 is associated with reduced insulin mediated glucose disposal and carbohydrate oxidation. The skeletal muscle specific calpain-3 plays a key role in skeletal muscle integrity and has also been linked to insulin resistance in humans and rodents. The major aims of this thesis were to 1) investigate the hypothesis that alterations in insulin sensitivity in healthy humans would lead to signific

APA, Harvard, Vancouver, ISO, and other styles

20

Bagstaff, Stephanie M. "Hyperinsulinemia and insulin resistance in cultured human muscle cells." Thesis, University of Newcastle Upon Tyne, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270177.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Potts, Jennifer Lucy. "Lipoprotein metabolism in human adipose tissue." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334875.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Nyman, Elin. "Insulin signaling dynamics in human adipocytes : Mathematical modeling reveals mechanisms of insulin resistance in type 2 diabetes." Doctoral thesis, Linköpings universitet, Avdelningen för cellbiologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-104725.

Full text

Abstract:

Type 2 diabetes is characterized by raised blood glucose levels caused by an insufficient insulin control of glucose homeostasis. This lack of control is expressed both through insufficient release of insulin by the pancreatic beta-cells, and through insulin resistance in the insulin-responding tissues. We find insulin resistance of the adipose tissue particularly interesting since it appears to influence other insulin-responding tissues, such as muscle and liver, to also become insulin resistant. The insulin signaling network is highly complex with cross-interacting intermediaries, positive a

APA, Harvard, Vancouver, ISO, and other styles

23

Borg, Mathias. "Study of the insulin-like peptide 3 in human platelets." Thesis, Linköping University, Department of Physics, Chemistry and Biology, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-21016.

Full text

Abstract:

<p>The insulin-like 3 peptide is autocrine/paracrine insulin-related hormone with a size of approximately 6kDa [1]. It mediates through a leucine richG-coupled receptor named LGR8. INSL3 is mainly expressed in human Leydig cells and is directly responsible for migration of the testis during the pre-natal period in maledevelopment. [2]</p><p>INSL3 mRNA has recently been verified in human platelets whereas no mRNA has been detected for LGR8 (by Sanofi-Aventis GmbH in Frankfurt,Germany), indicating that INSL3 might be released through paracrine functions at sites of platelet adhesion and aggregat

APA, Harvard, Vancouver, ISO, and other styles

24

Horn, Henrik von. "Regulation of insulin-like growth factor-II in human liver /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-880-0/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Armstrong, Jane Louise. "Insulin signalling to glycogen synthesis in cultured human muscle cells." Thesis, University of Newcastle Upon Tyne, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340684.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Donovan, Stephen James. "The regulation of human 11Î²-hydroxysteroid dehydrogenase." Thesis, University of Southampton, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323945.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Kruszynska, Y. T. "Metabolic effects of portal and peripheral insulin delivery in streptozotocin diabetic rats." Thesis, University of Newcastle Upon Tyne, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356789.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Björnholm, Marie. "Molecular mechanisms of insulin action in human skeletal muscle and adipose tissue : implications for diabetes and obesity /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-245-0.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Halse, Reza. "Control of glycogen synthesis in cultured human muscle." Thesis, University of Newcastle Upon Tyne, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310172.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Tang, Shiue-Cheng. "Genetic engineering of non-beta-cells for regulated insulin secretion." Diss., Available online, Georgia Institute of Technology, 2004:, 2003. http://etd.gatech.edu/theses/available/etd-04072004-180222/unrestricted/tang%5Fshiue-cheng%5F200312%5Fphd.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Löfgren, Patrik. "Studies on fat cell function in human obesity and insulin resistance /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-198-9/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

George, S. "Signal transduction defects in the human syndromes of severe insulin resistance." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599359.

Full text

Abstract:

This thesis describes the characterization of several mutations found in subjects with severe insulin resistance. The first mutation was found in an infant with the most severe type of insulin resistance-Donohue’s syndrome. This mutation (DV335) in the insulin receptor was found to cause abnormal processing such that only 30% of mature receptor was formed when compared to wild type. A mutation (E1092Q) in the cyclic GMP inhibited phosphodiesterase PDE3B was found in a patient with type A insulin resistance. Involved in the anti-lipolytic actions of insulin, the activation of PDE3B results in a

APA, Harvard, Vancouver, ISO, and other styles

33

Morrow, Valerie A. "Insulin regulation of nitric oxide production in human aortic endothelial cells." Thesis, University of Glasgow, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.401651.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Xu, Su. "Insulin-like growth factors and their binding proteins in human skin." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343351.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Hoo, Lai-chong Ruby, and 何麗莊. "Transcriptional regulation of the human glucose-dependent insulinotropic polypeptide gene." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31224428.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Rochford, Justin J. "Regulation of glycogen synthase kinase 3 in cultured human muscle." Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388659.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Hoo, Lai-chong Ruby. "Transcriptional regulation of the human glucose-dependent insulinotropic polypeptide gene." Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B22266665.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Lees, Justin Guy Clinical School Prince of Wales Hospital Faculty of Medicine UNSW. "Differentiation of human embryonic stem cells for the treatment of type 1 diabetes." Publisher:University of New South Wales. Clinical School - Prince of Wales Hospital, 2008. http://handle.unsw.edu.au/1959.4/41251.

Full text

Abstract:

A five stage selection protocol originally applied to mouse embryonic stem cells (mESCs) was examined for the derivation of insulin producing cells from human embryonic stem cells (hESCs). Insulin gene expression was observed and insulin protein was measured by radioimmunoassay. However, the radioimmunoassay results were shown to be susceptible to false positive findings due to the presence of exogenous insulin within differentiation media and it was concluded that this particular strategy was not ideal for the derivation of insulin producing cells from hESCs. An investigation was then underta

APA, Harvard, Vancouver, ISO, and other styles

39

El, Sanadi Caroline Elizabeth. "THE VALUE OF A FUNCTIONAL EXCIPIENT ADDITIVE TO HUMAN INSULIN THERAPIES: FROM MANUFACTURE TO HUMAN CLINICAL TRIAL." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1450286879.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Liao, Yu Huan. "Evaluation of insulin secretion by in vitro generated human islet-like clusters." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/2511.

Full text

Abstract:

Type 1 diabetes is an autoimmune disease in which patients' insulin-secreting beta cells in pancreatic islets are destroyed by their own immune system, leading to unregulated blood glucose levels and severe complications. Its only treatment is intensive insulin therapy, which carries the risk of hypoglycemic episodes and can result in seizures, coma, and even death. Islet transplantation has recently become an alternative, albeit experimental, treatment for type 1 diabetes patients. More than one donor graft is usually required to render recipients insulin independent, making the shortage of d

APA, Harvard, Vancouver, ISO, and other styles

41

Chan, Michelle Tsz Ting. "Regulation of primary, immortalized, and metatstatic human pancreatic ductal cells by insulin." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/43770.

Full text

Abstract:

Epidemiological studies have reported positive correlation between type 2 diabetes and risk of pancreatic cancer. Hyperinsulinemia occurring during early diabetes has been postulated to be a possible pathophysiological mechanism in promoting pancreatic cancer, but the mechanisms by which elevated insulin levels contribute to pancreatic carcinogenesis are still unknown. Here, the effects of insulin and its associated mechanism on cellular viability were examined in three cell models that are meant to represent three stages in pancreatic cancer progression. Furthermore, using small molecule inhi

APA, Harvard, Vancouver, ISO, and other styles

42

Lee, Adrian. "Analysis of insulin-like growth factor-II in human breast cancer cells." Thesis, University of Surrey, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335638.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Tan, Karen Mei Ling. "Functional characterization of naturally occurring human mutations causing insulin resistance and obesity." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612991.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Cheetham, Tim D. "The growth hormone/insulin-like growth factor I axis in insulin-dependent diabetes mellitus during adolescence : studies of recombinant human insulin-like growth factor I (rhIGF-I) administration." Thesis, University of Leicester, 1996. http://hdl.handle.net/2381/34300.

Full text

Abstract:

The fall in insulin sensitivity during adolescence is accentuated in insulin-dependent diabetes mellitus (IDDM) and has been linked to enhanced growth hormone (GH) secretion. The rise in GH release is related to low insulin-like growth factor I (IGF-I) levels and low IGF bioactivity. Abnormalities of the IGF binding proteins (IGFBP's), including low insulin-like growth factor binding protein-3 (IGFBP-3) and elevated insulin-like growth factor binding protein-1 (IGFBP-1) concentrations are also observed. The rise in GH concentrations may lead to increased insulin requirements that cannot easily

APA, Harvard, Vancouver, ISO, and other styles

45

Ong, Kenneth Kian Leong. "Longitudinal analysis of the insulin gene minisatellite and insulin-like growth factors in human size at birth and early childhood growth." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619807.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Senthilmohan, Tharmalingam. "The role of human alpha-2-macroglobulin in health and disease." Thesis, University of Sussex, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362274.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

DeSantis, Teresa Anna. "The effects of insulin and insulin-like growth factor-I on the replication of the human immunodeficiency virus type 1 in vitro /." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=55441.

Full text

Abstract:

Insulin and IGF-I, primarily considered to be metabolic and growth modulatory hormones, were found to inhibit HIV-1 replication in de novo infected CBMC and chronically infected U937 cells in vitro. The effect of IGF-I was seen at physiological concentrations or lower (1.3 $ times$ 10$ sp{-10}$ M) while that of insulin was observed at supraphysiological concentrations (8 $ times$ 10$ sp{-7}$ M). The EC$ sb{50}$ for IGF-I was found to be 2.5 to 4.5 $ times$ 10$ sp{-9}$ M and the EC$ sb{50}$ for insulin was found to be 1.1 to 1.3 $ times$ 10$ sp{-6}$ M. The insulin and ICF-I concentrations emplo

APA, Harvard, Vancouver, ISO, and other styles

48

Gulino, Angela Marie. "Insulin secretion dynamics of recombinant hepatic and intestinal cells." Thesis, Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/28220.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

Lighten, Antony David. "The role of the insulin-like growth factor family in human preimplantation development." Thesis, Imperial College London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298778.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Groshong, Jason S. "THE ROLE OF MACROPHAGES IN EXERCISE AND INSULIN RESISTANCE IN HUMAN SKELETAL MUSCLE." UKnowledge, 2013. http://uknowledge.uky.edu/physiology_etds/13.

Full text

Abstract:

Muscle biopsies were taken at baseline, post eccentric exercise, post aerobic training, and after training followed by eccentric exercise from adults with different health status. In Cell Western analysis of pAkt/Akt ratio suggests that muscle cells isolated from baseline biopsies respond to insulin in a dose dependent manner that tracks with sensitivity to insulin of the host; however, this is uncoupled from glucose disposal in vitro. Nitrotyrosine (NY), a marker of free radical damage, was employed to assess the efficacy of the exercise paradigm. NY immunohistochemistry on muscle cross-secti

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!