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Journal articles on the topic 'Human insulin'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Ray, Sumit. "Insulin infusion protocol (Human insulin®/Insugen®)." Current Medicine Research and Practice 4, no. 4 (2014): 186–87. http://dx.doi.org/10.1016/j.cmrp.2014.08.007.

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2

Mbanya, Jean Claude, Juergen Sandow, Wolfgang Landgraf, and David R. Owens. "Recombinant Human Insulin in Global Diabetes Management – Focus on Clinical Efficacy." European Endocrinology 13, no. 01 (2017): 21. http://dx.doi.org/10.17925/ee.2017.13.01.21.

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Biosynthetic human insulin and insulin analogues are the mainstay of insulin therapy for both type 1 and type 2 diabetes although access to human insulin at affordable prices remains a global issue. The world is experiencing an exponential rise in the prevalence of diabetes presenting an urgent need to establish effective diabetes therapy in countries burdened by inadequate health care budgets, malnutrition and infectious diseases. Recombinant human insulin has replaced animal insulins and animal-based semisynthetic human insulin thereby available in sufficient quantities and at affordable pri

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3

Sandow, Juergen, Wolfgang Landgraf, Reinhard Becker, and Gerhard Seipke. "Equivalent Recombinant Human Insulin Preparations and their Place in Therapy." European Endocrinology 11, no. 1 (2015): 10. http://dx.doi.org/10.17925/ee.2015.11.01.10.

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Recombinant human insulin was one of the first products of biotechnology. It was developed in response to the need for a consistent and sufficient worldwide supply. Recombinant human insulin replaced the animal insulins and semisynthetic insulins obtained by modification of animal insulins. Bioequivalence studies were required for regulatory approval. Three reference products were independently established during these procedures: Humulin® (Eli Lilly and Co), Novolin® (NovoNordisk) and Insuman® (Sanofi). Numerous brand names have been used during the commercial development of recombinant human

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4

Hale, Genevieve, Valerie Marcellus, Tina Benny, Cynthia Moreau, Elaina Rosario, and Alexandra Perez. "Real-World Analysis of Long-Acting and NPH-Containing Insulins on Glycemic Control." Senior Care Pharmacist 39, no. 1 (2024): 42–49. http://dx.doi.org/10.4140/tcp.n.2024.42.

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Introduction Affordability of insulin products has become a concern in the past several years as the average price of various insulin products has increased. While awaiting legislation at the federal level that would address issues leading to high insulin costs, providers may have shifted prescribing practices to prescribe the lowest-priced insulin products to achieve patients’ treatment goals. Objective To compare the prevalence of hypoglycemic events between patients receiving lower-cost neutral protamine Hagedorn (NPH)-containing human insulins and higher-cost long-acting insulin analogs in

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5

Ahmed Aziz, Kamran Mahmood. "Role of New Insulin Analogs in the Management of Diabetes. A Clinical Review." Diabetes & Obesity International Journal 8, no. 1 (2023): 1–8. http://dx.doi.org/10.23880/doij-16000269.

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This paper has reviewed different insulin analogs currently available in the market and pharma industry, their safety, efficacy and their roles in the diabetes management, comparing with human regular and NPH insulin. Traditional insulins (human regular and NPH insulins) do not have constant or smoother pharmacokinetic and pharmacodynamic profiles and are usually associated with erratic blood glucose profiles with hypoglycemia or hyperglycemia when compared with analog insulins. Similarly they do not match physiologic insulin profiles with basal bolus format. According to the medical literatur

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6

Dzhavakhishvili, T. S., T. I. Romantsova, and O. V. Roik. "Influence of the dynamics of body weight on the risk factors of cardiovascular disease in patients with type 2 diabetes during the first year of insulin treatment." Obesity and metabolism 10, no. 1 (2013): 22–25. http://dx.doi.org/10.14341/2071-8713-5067.

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The aim of the present study was to investigate whether insulin treatment-induced weight gain had an adverse impact on cardiovascular risk factors in insulin-treated type 2 diabetic patients during the first year after initiating insulin therapy when insulin analogues or human insulins are used. A total of 157 patients with newly insulinized type 2 diabetes were included in the study. The patients were divided in two groups. First group consisted of subjects (mean age 57 [45; 73], duration of diabetes of 10 years [4; 16]) who had received long-acting basal (glargine, detemir), premixed (biphas

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7

Broussard, John D., and Mark E. Peterson. "Comparison of two ultralente insulin preparations with protamine zinc insulin in clinically normal cats." American Journal of Veterinary Research 55, no. 1 (1994): 127–31. http://dx.doi.org/10.2460/ajvr.1994.55.01.127.

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Summary The absorption kinetics and glycemic effects of 3 long-acting insulin preparations (protamine zinc beefpork insulin, ultralente beef-pork insulin, and ultralente human insulin) were evaluated in 9 healthy, adult, domestic shorthair cats (6 males, 3 females). A triple crossover study was performed, in which the serial serum concentrations of insulin and glucose were determined over a 24-hour period after SC administration of the 3 insulin preparations (dosage, 1.0 U/kg of body weight) at 3-week intervals. A control study was also performed in 4 of the cats by serially collecting samples

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8

Ndayishimye, Samuel *. Prudence A. Rodrigues. "HUMAN INSULIN AND INSULIN ANALOGUES IN MANAGEMENT OF DIABETES MELLITUS." Journal of Pharma Research 7, no. 10 (2018): 224–26. https://doi.org/10.5281/zenodo.1468476.

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<em>ABSTRACT</em> <strong><em>T</em></strong><em>he aim of the study was to determine the outcomes of human insulin and insulin analogues in the management of diabetes mellitus. Since good glycemic control is needed for diabetic insulin analogues are having faster onset and shorter duration of action when compared to human insulin. Insulin analogues show improvements in clinical outcomes, medication adherence and patient satisfaction. When compared with human insulin, insulin analogues are having lesser episodes of hypoglycemia. Premixed insulin analogues show little benefits than Rapid and lo

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9

&NA;. "Insulin human." Reactions Weekly &NA;, no. 587 (1996): 5. http://dx.doi.org/10.2165/00128415-199605870-00017.

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10

&NA;. "Insulin human." Reactions Weekly &NA;, no. 588 (1996): 8. http://dx.doi.org/10.2165/00128415-199605880-00025.

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11

&NA;. "Insulin human." Reactions Weekly &NA;, no. 589 (1996): 8. http://dx.doi.org/10.2165/00128415-199605890-00022.

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12

&NA;. "Insulin human." Reactions Weekly &NA;, no. 599 (1996): 6. http://dx.doi.org/10.2165/00128415-199605990-00019.

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13

&NA;. "Insulin human." Reactions Weekly &NA;, no. 428 (1992): 8. http://dx.doi.org/10.2165/00128415-199204280-00036.

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14

&NA;. "Insulin human." Reactions Weekly &NA;, no. 452 (1993): 8. http://dx.doi.org/10.2165/00128415-199304520-00035.

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&NA;. "Insulin human." Reactions Weekly &NA;, no. 457 (1993): 10. http://dx.doi.org/10.2165/00128415-199304570-00040.

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&NA;. "Insulin human." Reactions Weekly &NA;, no. 462 (1993): 10. http://dx.doi.org/10.2165/00128415-199304620-00054.

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17

Brogden, R. N., and R. C. Heel. "Human Insulin." Drugs 34, no. 3 (1987): 350–71. http://dx.doi.org/10.2165/00003495-198734030-00003.

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18

&NA;. "Insulin human." Reactions Weekly &NA;, no. 630 (1996): 8. http://dx.doi.org/10.2165/00128415-199606300-00018.

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19

&NA;. "Insulin human." Reactions Weekly &NA;, no. 638 (1997): 8–9. http://dx.doi.org/10.2165/00128415-199706380-00024.

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20

&NA;. "Insulin human." Reactions Weekly &NA;, no. 671 (1997): 9. http://dx.doi.org/10.2165/00128415-199706710-00019.

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21

&NA;. "Insulin human." Reactions Weekly &NA;, no. 683 (1998): 9. http://dx.doi.org/10.2165/00128415-199806830-00022.

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22

&NA;. "Insulin human." Reactions Weekly &NA;, no. 689 (1998): 9. http://dx.doi.org/10.2165/00128415-199806890-00028.

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23

&NA;. "Human insulin." Reactions Weekly &NA;, no. 370 (1991): 6. http://dx.doi.org/10.2165/00128415-199103700-00024.

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24

&NA;. "Insulin human." Reactions Weekly &NA;, no. 383 (1992): 8. http://dx.doi.org/10.2165/00128415-199203830-00042.

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25

&NA;. "Insulin human." Reactions Weekly &NA;, no. 283 (1990): 6. http://dx.doi.org/10.2165/00128415-199002830-00023.

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26

&NA;. "Insulin human." Reactions Weekly &NA;, no. 289 (1990): 8–9. http://dx.doi.org/10.2165/00128415-199002890-00034.

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27

&NA;. "Insulin human." Reactions Weekly &NA;, no. 292 (1990): 6–7. http://dx.doi.org/10.2165/00128415-199002920-00023.

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28

&NA;. "Insulin human." Reactions Weekly &NA;, no. 295 (1990): 6. http://dx.doi.org/10.2165/00128415-199002950-00025.

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29

&NA;. "Insulin human." Reactions Weekly &NA;, no. 297 (1990): 8. http://dx.doi.org/10.2165/00128415-199002970-00034.

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&NA;. "Insulin human." Reactions Weekly &NA;, no. 298 (1990): 6. http://dx.doi.org/10.2165/00128415-199002980-00026.

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31

&NA;. "Insulin human." Reactions Weekly &NA;, no. 322 (1990): 8–9. http://dx.doi.org/10.2165/00128415-199003220-00031.

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32

&NA;. "Insulin human." Reactions Weekly &NA;, no. 333 (1991): 8. http://dx.doi.org/10.2165/00128415-199103330-00038.

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33

&NA;. "Insulin human." Reactions Weekly &NA;, no. 354 (1991): 9. http://dx.doi.org/10.2165/00128415-199103540-00038.

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34

Stocks, Alan E. "Human insulin." Medical Journal of Australia 154, no. 4 (1991): 295–96. http://dx.doi.org/10.5694/j.1326-5377.1991.tb121117.x.

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35

Miller, John J. "Human insulin." Medical Journal of Australia 154, no. 4 (1991): 296. http://dx.doi.org/10.5694/j.1326-5377.1991.tb121118.x.

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36

Breidahl, Harald D. "Human insulin." Medical Journal of Australia 154, no. 7 (1991): 493–94. http://dx.doi.org/10.5694/j.1326-5377.1991.tb121203.x.

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37

&NA;. "Insulin human." Reactions Weekly &NA;, no. 477 (1993): 8. http://dx.doi.org/10.2165/00128415-199304770-00034.

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38

&NA;. "Insulin human." Reactions Weekly &NA;, no. 486 (1994): 8. http://dx.doi.org/10.2165/00128415-199404860-00035.

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39

&NA;. "Insulin human." Reactions Weekly &NA;, no. 501 (1994): 9. http://dx.doi.org/10.2165/00128415-199405010-00037.

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40

Kiln, M. R., and Amanda Sugarman. "Human insulin." Nature 358, no. 6381 (1992): 10. http://dx.doi.org/10.1038/358010e0.

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41

Williams, Gareth, and Alan W. Patrick. "Human insulin." Nature 359, no. 6394 (1992): 355. http://dx.doi.org/10.1038/359355c0.

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42

Ahrens, Edward R., Ved V. Gossain, and David R. Rovner. "Human insulin." Postgraduate Medicine 80, no. 1 (1986): 181–87. http://dx.doi.org/10.1080/00325481.1986.11699459.

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43

Felner, E. I. "Insulin (Human)." Clin-Alert 41, no. 9 (2003): 8. http://dx.doi.org/10.1177/0069477003041009015.

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44

Heding, Lise G. "Human Insulin." Acta Medica Scandinavica 213, S671 (2009): 107–15. http://dx.doi.org/10.1111/j.0954-6820.1983.tb08556.x.

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45

Home, P. "Human insulin." BMJ 292, no. 6520 (1986): 625–26. http://dx.doi.org/10.1136/bmj.292.6520.625-d.

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46

Pickup, J. "Human insulin." BMJ 292, no. 6520 (1986): 626. http://dx.doi.org/10.1136/bmj.292.6520.626.

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47

Olczak, S. A., and R. H. Greenwood. "Human insulin." BMJ 292, no. 6522 (1986): 763. http://dx.doi.org/10.1136/bmj.292.6522.763.

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48

Matthews, D. M. "Human insulin." BMJ 303, no. 6812 (1991): 1265. http://dx.doi.org/10.1136/bmj.303.6812.1265-a.

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49

Watkins, P. J. "Human insulin." BMJ 303, no. 6812 (1991): 1265. http://dx.doi.org/10.1136/bmj.303.6812.1265-b.

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50

Walker, J. D. "Human insulin." BMJ 303, no. 6812 (1991): 1265–66. http://dx.doi.org/10.1136/bmj.303.6812.1265-c.

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