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Dissertations / Theses on the topic 'Human platelet'

Author: Grafiati

Published: 21 February 2023

Last updated: 25 July 2025

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1

Bunescu, Andreia. "Cellular markers indicating activation of the hemostatic system : studies on platelets and leukocytes in peripheral human blood /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-759-2/.

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2

Rolf, Michael George. "P2X₁ receptors and human platelet function." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621241.

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3

Sato, Masami. "Effects of barbiturates on human platelet aggregation." Kyoto University, 2003. http://hdl.handle.net/2433/148488.

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4

Zijenah, Lynn Sodai. "The platelet-reactivity of human collagens I and III : investigation of platelet-reactive sites in the human collagen molecule." Thesis, University of Cambridge, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359782.

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5

Bienz, Denise Edith. "Human blood platelets : the role of glycoproteins in the platelet interaction with thrombin and collagen /." [S.l.] : [s.n.], 1988. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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6

Scott, Nigel T. "Investigations on human factor 8 and platelet function." Thesis, University of East London, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.353257.

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7

Bouwmans, Eva Lamberta Antonia. "Human platelet antigen-1a presentation and antibody generation." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610311.

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8

Simpson, Craig J. "Studies on the structure of human platelet phosphofructokinase." Thesis, University of Edinburgh, 1991. http://hdl.handle.net/1842/20189.

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Phosphofructokinase (ATP: D-fructose 6-phosphate 1-transferase, EC 2.7.1.11) catalyses the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate, and is a key regulatory enzyme in glycolysis. Sequence conservation between mammalian PFK and PFK from <i>E.coli, B.stearothermophilus</i> and <i>S.citri</i>, and between the amino and carboxyl halves of the mammalian enzymes suggests that mammalian PFK has evolved from a prokaryotic progenitor by a process of gene duplication and fusion. The aim of this project was to obtain detailed structural information describing PFK from humans a

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9

Baker, Jennifer Mary. "The effect of extracellular pH on human platelet metabolism." Thesis, University of Birmingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368422.

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10

Hall, David A. "The biochemical pharmacology of the human platelet ADP receptor." Thesis, University of Surrey, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385201.

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11

Caine, Graham James. "Coagulation, platelet activation, inflammation and angiogenesis in human cancer." Thesis, Birmingham City University, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421827.

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12

Arnaud, F. G. "Cryopreservation of human blood platelets in the presence of propane-1,2-diol." Thesis, Open University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233558.

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13

Cook, Nia. "Characterisation and agonist regulation of the human platelet β-adrenoceptor". Thesis, University of Leicester, 1988. http://hdl.handle.net/2381/35861.

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14

Vishnubhatla, Indira. "Studies on the effects of storage on human platelet phospholipids." Thesis, University of Ottawa (Canada), 1986. http://hdl.handle.net/10393/5399.

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15

Qu, Jiamin. "Effects of platelet-derived growth factor on human neutrophil function." Thesis, Open University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385249.

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16

Rashid, Shahila. "Characterisation of human platelet alpha-adrenoceptors and 5 HT-receptors." Thesis, Manchester Metropolitan University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278003.

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17

Kawamoto, Shuji. "Bidirectional effects of dexmedetomidine on human platelet functions in vitro." Kyoto University, 2016. http://hdl.handle.net/2433/215391.

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18

Chase, Peter Burritt 1955. "The molecular pharmacology of a human platelet-activating factor receptor." Diss., The University of Arizona, 1996. http://hdl.handle.net/10150/290574.

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Platelet-activating factor (PAF) is a broadly bioactive family of phospholipids which contribute to the pathogenesis of numerous diseases as well as to many normal physiologic processes. The pleiotropic nature of PAFs actions may be due to the activation of several intracellular signaling pathways or the presence of PAF receptor subtypes. Therefore, to begin to understand the complex mechanisms by which PAF molecules induce cellular responses, a molecular approach was initiated to provide tools to investigate many of the issues surrounding PAF receptors. Using a strategy based upon homology cr

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19

Bosnic, Anthony Martin. "Human antibody responses to a chlamydia-secreted protease factor : a thesis /." San Antonio : UTHSC, 2005. http://learningobjects.library.uthscsa.edu/cdm4/item%5Fviewer.php?CISOROOT=/theses&CISOPTR=14&REC=5.

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20

Pedvis, Lloyd Gary. "Differential activation and inhibition of human platelet shape change, micro- and macroaggregation, in whole blood and platelet-rich plasma." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61878.

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21

Allen, David L. "A study of the Human Platelet Antigen 1a (HPA-1a) antibody response in neonatal alloimmune thrombocytopenia (NAIT)." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:44a10539-de5d-44dc-9c51-5f43cf3c3a82.

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Neonatal alloimmune thrombocytopenia (NAIT) is caused by maternal alloantibodies against fetal platelet antigens inherited from the father and which are absent from maternal platelets. In Caucasians, antibodies against the Leu33 (HPA-1a) polymorphism of integrin β3 (part of the platelet αIIbβ3 complex) account for >70% of cases. Antenatal screening for these antibodies does not currently take place in the UK, partly because of the absence of sensitive, predictive tests. We hypothesized that the poor sensitivity and predictive abilities of current assays are due to the use of β3 in an inappropr

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22

Teoh, Diane Marie. "Platelet-Activating Factor, PAF, and its effects on human neutrophil CD43." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0018/MQ49657.pdf.

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23

Gray, S. J. "Studies of cyclic AMP in relation to human blood platelet behaviour." Thesis, University of Nottingham, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235383.

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24

Manning, Susan Diane. "Ion channels in highly purified human platelet surface and intracellular membranes." Thesis, Imperial College London, 1990. http://hdl.handle.net/10044/1/46431.

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25

Andersen, Henrik. "Human protease activated receptor 4 and its role in platelet activation /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/9235.

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26

Holland, Errol Anthony. "The platelet laminin receptor : discovery of a 67kDA receptor for laminin on the membranes of human platelets : characterisation and isolation." Doctoral thesis, University of Cape Town, 1995. http://hdl.handle.net/11427/27034.

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Previous work on the binding of resting platelets to the basement membrane glycoprotein, laminin, has identified the Ic/IIa integrin c01aplex (CD49f/CD29), also known as VLA-6, as the receptor. There exists however, another protein with a molecular weight of 67kDa, that mediates this function on other cells. It is abundantly expressed on the membranes of breast cancer cells, where it plays a key role in both the localisation at, and penetration of vascular beds, by metastases. The objectives of this study were: * The development of a micro-titre assay similar to those used in previous studies,

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27

Willoughby, Scott R. "Inhibition of human platelet aggregation by perhexiline maleate : mechanisms and therapeutic implications /." Title page, contents and summary only, 1999. http://web4.library.adelaide.edu.au/theses/09PH/09phw739.pdf.

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28

Lee, Vivian S. "Optical studies of human blood cells : the quantitative determination of platelet viability." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.291299.

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29

Kurlak, Lesia Olha. "The influence of membrane properties on platelet aggregation in the human neonate." Thesis, University of Nottingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272377.

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30

Appleyard, Caroline Barbara. "The synthesis and catabolism of Platelet Activating Factor in human colon mucosa." Thesis, University of Southampton, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359303.

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31

Qureshi, Shahryar Jamshed. "Nanomaterial Charge-Dependent Platelet Activating Factor Receptor Agonism in Human Epidermal Cells." Wright State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=wright1535391805311408.

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32

ARNONE, ROSARIA. "Intracellular and surface redox systems in human platelets." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2010. http://hdl.handle.net/2108/1195.

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Redox balance is important for platelet physiology, indeed it is crucial for blood coagulation and thrombosis. This thesis will give an update on intracellular and plasma membrane systems involved on redox homeostasis in human platelets, with particular regard to vitamin C and plasma membrane NAD(P)H oxidases. The redox balance is linked to the presence of intracellular antioxidants; in particular, vitamin C appears to be a key modulator of platelet oxidative state, since these cells physiologically accumulate ascorbic acid. Here, we showed, for the first time, that platelets could compensat

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33

Anani, Sarab Gholamreza. "Construction, expression and antigenic characterisation of recombinant human platelet antigen-1 (HPA-1)." Thesis, University of Aberdeen, 2010. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=158493.

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Previously it has been shown that sequences containing both Trp<sup>25</sup> and Leu<sup>33</sup> are the most effective at inducing Th cell proliferation in HLA-DRB3*0101 positive women, alloimmunised with anti-HPA-1a. The Leu<sup>33</sup>/Pro<sup>33</sup> polymorphism is embedded in the N-terminal plexin/semaphorin/integrin (PSI) domain of GPIIIa. In the present study, amino acids 1-62 of the GPIIIa (Leu<sup>33</sup> or Pro<sup>33</sup>) PSI domain were cloned into the vector pGEX-6p-1. The recombinant proteins were expressed and tested by ELISA, Luminex and Absorption Assays. The presen

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34

Wecksler, Aaron Thomas. "Allosteric, mechanistic, and inhibitory investigations of human platelet 12-lipoxygenase, human reticulocyte 15-lipoxygenase-1 and human epithelial 15-lipoxygenase-2 /." Diss., Digital Dissertations Database. Restricted to UC campuses, 2009. http://uclibs.org/PID/11984.

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35

Santos, Sara Catarina Nunes da Silva. "Development of injectable hydrogels derived from human platelest lysates." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22668.

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Mestrado em Bioquímica<br>A medicina regenerativa e a engenharia de tecidos surgiram como alternativas para as terapias atualmente usadas no tratamento e substituição de tecidos ou órgãos lesados. Estas novas terapias combinam o uso de materiais sintéticos ou biológicos ou uma combinação de ambos por forma a produzir um tecido com a mesma estrutura e funcionalidade do original, contribuindo para o tratamento de tecidos e órgãos lesados. No tecido nativo, as células estão rodeadas por uma matriz extracelular que fornece suporte mecânico e biológico às mesmas. Hidrogéis são redes poliméricas com

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36

Bodie, Susan L. "Regulation of myosin light chainâ†2â†0 phosphorylation in human platelet shape change." Thesis, University of Aberdeen, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394650.

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Myosin light chain<sub>20</sub> (MLC<sub>20</sub>) phosphorylation is thought to be responsible for the initiation of platelet shape change. The aim of this study was to investigate the regulation of MLC<sub>20</sub> phosphorylation in platelet shape change. Previous studies have suggested that MLC<sub>20</sub> phosphorylation following platelet stimulation is dependent on intracellular calcium release. This study was designed to investigate the role of calcium sensitization in human platelet shape change and the possible intracellular mechanisms involved. An α-toxin permeabilized platelet mod

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37

Ahn, Chang-Ho. "Mechanism of action of prostaglandin endoperoxide (U46619) and trimetoquinol on human platelet function /." The Ohio State University, 1985. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487261553057595.

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38

De, Leon Ellen Jane Biotechnology &amp Biomolecular Sciences Faculty of Science UNSW. "Engineering antibodies against complex platelet antigens using phage display technology." Awarded by:University of New South Wales, 2007. http://handle.unsw.edu.au/1959.4/37009.

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Platelets are small anucleate cell fragments found in blood whose physiological role is important in maintaining haemostasis. In vivo, platelet surface glycoproteins mediate the mechanistic roles of platelets, and polymorphic changes to these glycoproteins have been observed to have significant effects on the platelet cellular function and such changes may include over-expression, under-expression and antigenicity of the protein. Human platelet antigens (HPA) are a result of polymorphic differences in platelet surface glycoproteins which have been found to be variably expressed in the populati

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39

Lin, Liwen. "Comprehensive identification of nitroxyl-reactive cysteines in human platelet proteins by quantitative mass spectrometry." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/37089.

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HNO, a small compound which can be produced upon hydrolysis of Angeli’s Salt, is known to be able to inhibit platelet aggregation. An important step to elucidate the mechanism of the antiaggregatory effect of HNO and define the drug’s targets is the identification of HNO-reactive proteins in platelets. The sulfhydryl group is considered the major target of HNO. It can be modified into either sulfinamide or disulfide. The sulfinamide modification is directly detectable by mass spectrometry; however, cysteines converted into disulfide groups by HNO cannot be monitored this way, because the origi

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40

Wadman, Isobel A. "The regulation of human platelet adenylate cyclase by ATP and guanine nucleotide binding proteins." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241124.

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41

Dietrich, Joanna Louise. "Phosphorylation of human platelet cytosolic phospholipase A₂ by the Src-family protein tyrosine kinases." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621659.

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42

Min, Jung-Hyun. "Enzyme mechanism, substrate specificity, and lipoprotein association of human plasma platelet-activating factor acetylhydrolase /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/9254.

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43

Xu, Hui 1958. "Characterization of the biochemical and functional properties of platelet proteins recognized by human hybridoma autoantibodies." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=28553.

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Anti-platelet autoantibodies may be responsible for hematological complications in patients with systemic lupus erythematosus (SLE), but the mechanisms by which these antibodies cause abnormal hemostasis remain unknown. In the present study, we demonstrate that an SLE-derived human hybridoma autoantibody, 9604, recognizes a surface antigen expressed on platelets activated by adenosine diphosphate (ADP), calcium ionophore A23187, or phorbol myristate acetate (PMA), showing saturation with approximately 2,000 antibody molecules bound and a K$ rm sb{d}$ of 41 nM. This antibody did not affect shap

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44

Bachmair, Eva-Maria. "Modulation of human platelet function by conjugated linoleic acid from a proteomics and functional perspective." Thesis, University of Aberdeen, 2013. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=201837.

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45

Hughes, Kevin Richard. "Studies of isoforms of platelet-derived growth factor and their receptors in human intestinal myofibroblasts." Thesis, University of Nottingham, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430317.

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46

Othman, Roohaida. "The design, synthesis and expression of human platelet derived phospholipase Aâ†2 in Escherichia coli." Thesis, University of Southampton, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295850.

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47

Bonazza, V. "SILICON AND PLATELET CONCENTRATES IN TISSUE REGENERATION:AN ¿IN VITRO¿ STUDY." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/465641.

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Tissue regeneration is a complex process of healing and tissue growth, which involves different biological elements and strategies, including the use of autologous cells, growth factors and scaffolds. All of these elements are present in platelet concentrates, such as Concentrated Growth Factors (CGF). Moreover, some trace elements play an important role in enhancing cell growth and proliferation and so tissue development and regeneration. Among these, Silicon seems to be beneficial for different organs and tissues, such as: bone and cartilage, brain, skin, nails and hair, cardiovascular syst

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48

Morris, Timothy J. "Exploring the improvement of human cell cryopreservation." Thesis, Loughborough University, 2015. https://dspace.lboro.ac.uk/2134/19279.

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Regenerative medicine is an emerging technology and with hundreds of cell therapies currently in clinical trials there is a need to expand the limited knowledge related to their storage, shipment and preservation. The most widely used medium for human cell cryopreservation is 10%wt dimethyl sulfoxide (DMSO) in serum. However given its potential toxicity, DMSO usage is a key issue in cryopreservation. Methods specify the need to reduce cell exposure time to DMSO above 0°C as much as possible but the maximum amount of time cells can be exposed to DMSO to prevent a detrimental effect needs to be

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49

Glazier, Thomas F., Thomas C. Waldrop, John C. Gunsolley, and Robert Sabatini. "The Role of Leukocyte-Platelet Rich Fibrin in Human Alveolar Ridge Preservation: A Randomized Clinical Trial." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3735.

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PURPOSE: The aim of this study is to examine the healing of intact extraction sockets grafted with leukocyte-platelet rich fibrin (L-PRF) as compared to sockets grafted with freeze-dried bone allograft (FDBA) and a resorbable collagen barrier membrane (RCM). METHODS: This prospective randomized, examiner blinded pilot study included 17 subjects randomized to two treatment groups. Serum total cholesterol, low density lipoprotein (LDL), 25-hydroxyvitamin-D3, and platelet counts were determined preoperatively in all subjects. The experimental arm consisted of 8 posterior tooth-bounded intact extr

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50

Al-Arayyed, Najah Abdulwahab. "Influence of the #alpha#1-adrenoceptor antagonists naftopidil and doxazosin on human platelet function in vitro." Thesis, University College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362508.

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