Relevant bibliographies by topics / Huperzina A

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Academic literature on the topic 'Huperzina A'

Author: Grafiati
Published: 4 June 2021
Last updated: 17 February 2022

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Journal articles on the topic "Huperzina A"

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Xu, Maonian, Starri Heidmarsson, Margret Thorsteinsdottir, et al. "Infraspecific Variation of Huperzine A and B in Icelandic Huperzia selago Complex." Planta Medica 85, no. 02 (2018): 160–68. http://dx.doi.org/10.1055/a-0752-0295.

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AbstractThe alkaloids huperzine A and huperzine B were originally isolated from the Chinese club moss Huperzia serrata. They are known inhibitors of acetylcholinesterase, and especially huperzine A shows pharmaceutical potential for the treatment of Alzheimerʼs disease. Its supply heavily relies on natural plant sources belonging to the genus Huperzia, which shows considerable interspecific huperzine A variations. Furthermore, taxonomic controversy remains in this genus, particularly in the Huperzia selago group. With focus on Icelandic H. selago taxa, we aimed to explore the relatedness of Hu
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Ngọc, Vũ Thị, Phạm Thị Hạnh, Lê Thị Lan Anh, Nguyễn Tiến Đạt, and Lê Thị Bích Thủy. "Qualification and quantification of huperzine a from Huperia serrata in Da Lat, Lam Dong province." Vietnam Journal of Biotechnology 14, no. 3 (2016): 473–78. http://dx.doi.org/10.15625/1811-4989/14/3/9861.

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Huperzine A, an alkaloid, was originally isolated from Huperzia serrata. This compound potentially enhances the memory in animal, hence, it has been approved as a drug for the clinical treatment of Alzheimer’s disease, a major disease affecting the elderly population throughout the world. Because Huperzine A is an acetylcholinesterase inhibitor, the presentation of Huperzine A in brain inhibited acetylcholinesterase activity, thus, leading to the increase in concentration of acetylcoline. In Vietnam, H. serrata distributed in Sapa (Lao Cai) and Da Lat (Lam Dong), this species provide valuable
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Patočka, Jiří. "Huperzine A - An Interesting Anticholinesterase Compound from the Chinese Herbal Medicine." Acta Medica (Hradec Kralove, Czech Republic) 41, no. 4 (1998): 155–57. http://dx.doi.org/10.14712/18059694.2019.181.

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Huperzine A, alkaloid from the Chinese herbal medicine Qian Ceng Ta, which is prepared from the moss Huperzia serrata, has been used in China for centuries to treat fever and inflammation. Huperzine A is a strong inhibitor of cholinesterases with high selectivity to acetylcholinesterase and in China is developed as therapeutic against Alzheimer's disease. May be that huperzine A will be better than other centrally active anticholinesterases in treating this neurodegenerative disorder. Huperzine A appears to have additional pharmacological properties that make it an attractive candidate therapy
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Tan, Chang-Heng, Xiao-Qiang Ma, Guo-Fu Chen, and Da-Yuan Zhu. "Huperzines S, T, and U: New Lycopodium alkaloids from Huperzia serrata." Canadian Journal of Chemistry 81, no. 4 (2003): 315–18. http://dx.doi.org/10.1139/v03-067.

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Three new Lycopodium alkaloids, huperzines S (1), T (2), and U (3), along with eight known compounds, were isolated from the total alkaloids of the whole plant of Huperzia serrata (Thunb) Trev. (Huperziaceae). Those novel alkaloids were identified as 2β,13β-epoxyalopecuridine (1), 5α-hydroxy-6-oxodihydrophlegmariurine A (2), and 2,3-dihydro-12-hydroxyhuperzine B (3), respectively, by means of spectral techniques including NMR studies.Key words: Huperzia serrata, Lycopodium alkaloids, huperzines S, T, U.
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Nguyen, Ngoc Chuong, Dinh Vinh, Duc Tuan Nguyen, Huynh Van Thi Nguyen, Cong Luan Tran, and Manh Hung Tran. "Development of a Capillary Electrophoretic Method for the Determination of Huperzine A Concentration in Vietnamese Huperzia serrata." Natural Product Communications 16, no. 9 (2021): 1934578X2110332. http://dx.doi.org/10.1177/1934578x211033225.

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Huperzine A, isolated from Huperzia serrata, is a potent, specific, and reversible inhibitor of acetylcholinesterase with high efficiency and low toxicity. To evaluate the presence of huperzine A in Vietnamese H serrata, a reliable capillary zone electrophoresis method was developed. The analytical conditions were established using 80 mM ammonium acetate buffer, pH 6.0, hydrodynamic injection at 50 mbar for 5 s, applied voltage of 20 kV, temperature at 25 °C, uncoated fused-silica capillary, 56 cm (50 cm effective length) × 70 µm inner diameter, and ultraviolet detection at 310 nm. The recover
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Ma, Xiaoqiang, Changheng Tan, Dayuan Zhu, David R. Gang, and Peigen Xiao. "Huperzine A from Huperzia species—An ethnopharmacolgical review." Journal of Ethnopharmacology 113, no. 1 (2007): 15–34. http://dx.doi.org/10.1016/j.jep.2007.05.030.

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Zhang, Yanqing, Junbo Xie, Wen-Qian Chen, Tian-Yan Zhou, and Wei Lu. "Development of a Sensitive High-Performance Liquid Chromatographic Method with Simple Extraction for Simultaneous Determination of Huperzine A and Huperzine B in the Species Containing Lycopodium Alkaloids." Journal of AOAC INTERNATIONAL 92, no. 4 (2009): 1060–63. http://dx.doi.org/10.1093/jaoac/92.4.1060.

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Abstract A sensitive HPLC method with simple extraction was developed for simultaneous determination of huperzine A (HupA) and huperzine B (HupB) in Huperzia serrata, H. crispata, H. miyoshiana, and Lycopodiastrum casuarinoides. In order to avoid conventional multiple-step and time-consuming sample preparation methods, direct reflux extraction with alkaline chloroform was adopted. The quantitative determination was conducted by reversed-phase HPLC with a photodiode array detector set at 308 nm. Separation was performed on a Luna C18 column (250 4.6 mm id, 5 m) with methanol0.2 aqueous acetic a
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Tan, Chang-Heng, Shan-Hao Jiang, and Da-Yuan Zhu. "Huperzine P, a novel Lycopodium alkaloid from Huperzia serrata." Tetrahedron Letters 41, no. 30 (2000): 5733–36. http://dx.doi.org/10.1016/s0040-4039(00)00893-5.

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Goodger, Jason Q. D., Anne L. Whincup, Ashley R. Field, Joseph A. M. Holtum, and Ian E. Woodrow. "Variation in huperzine A and B in Australasian Huperzia species." Biochemical Systematics and Ecology 36, no. 8 (2008): 612–18. http://dx.doi.org/10.1016/j.bse.2008.05.006.

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Szypuła, Wojciech J., Beata Wileńska, Aleksandra Misicka, and Agnieszka Pietrosiuk. "Huperzine A and Huperzine B Production by Prothallus Cultures of Huperzia selago (L.) Bernh. ex Schrank et Mart." Molecules 25, no. 14 (2020): 3262. http://dx.doi.org/10.3390/molecules25143262.

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This is the first report of an efficient and effective procedure to optimize the biosynthesis of huperzine A (HupA) and huperzine B (HupB) in vitro from Huperzia selago gametophytes. Axenic tissue cultures were established using spores collected from the sporophytes growing in the wild. The prothalia were obtained after 7–18 months. Approximately 90 up to 100% of the gametophytes were viable and grew rapidly after each transfer on to a fresh medium every 3 months. The best biomass growth index for prothallus calculated on a fresh (FW) and dry weight (DW) basis, at 24 weeks of culture, was 2500
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Dissertations / Theses on the topic "Huperzina A"

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Lunardi, Paula Santana. "Efeito da huperzina-A sobre a secreção de S100B em cultura primária de astrócitos e fatias hipocampais." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2010. http://hdl.handle.net/10183/27999.

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A doença de Alzheimer (DA) resulta de múltiplos eventos patogênicos, que incluem anormalidades no processamento protéico, inflamação e estresse oxidativo, levando à destruição seletiva de populações neuronais, especialmente de neurônios colinérgicos. Tal hipótese colinérgica justifica o uso de inibidores da acetilcolinesterase (AChE) como a estratégia utilizada para tratamento de pacientes com DA. Huperzina A (HupA), um alcalóide Licopodium extraído de uma espécie vegetal (Huperzia serrata) de uso tradicional pela medicina chinesa, parece se apresentar como uma alternativa. A HupA atua como um
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Lunardi, Paula Santana. "Perfil da ativação dos astrócitos em diferentes modelos biológicos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2014. http://hdl.handle.net/10183/101643.

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Apesar de representarem cerca de 50% de todas as células do encéfalo humano, as células da glia foram negligenciadas pela Doutrina do Neurônio, no início do século XX, por não serem excitáveis e por não se comunicarem como os neurônios. Durante um longo período, os estudos sobre os astrócitos se restringiam a suas funções de suporte do SNC. Atualmente se sabe que os astrócitos expressam receptores para uma variedade de neurotransmissores, como por exemplo, receptores colinérgicos nicotínicos, sugerindo possíveis mecanismos de resposta aos sinais enviados pela atividade neuronal, de modo variáv
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Alcalà, Cañadas Ma del Mar. "Estudio farmacológico de nuevos anticolinesterásicos híbridos tracina-huperzina A potencialmente útiles para el tratamiento de la enfermedad de Alzheimer." Doctoral thesis, Universitat Autònoma de Barcelona, 2003. http://hdl.handle.net/10803/5374.

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La enfermedad de Alzheimer (AD) es uno de los trastornos neurodegenerativos más importantes que afectan a las personas de edad avanzada, y tan sólo los fármacos anticolinesterásicos han probado tener cierta utilidad en la terapéutica de esta enfermedad. En el presente trabajo de tesis doctoral se han evaluado diversas características farmacológicas de dos nuevos anticolinesterásicos híbridos tacrina-huperzina A, (±)-huprina Y (huprina Y) y (±)-huprina Z (huprina Z). Mediante el método de Ellman se determinó la inhibición de los enzimas acetilcolinesterasa (AChE) bovina y humana y butirilcoline
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Román, Mejías Susana. "Caracterización colinérgica de la (+/-) huprina x, un anticolinesterásico híbrido tacrina-huperzina A, con potencial interés para el tratamiento sintomatológico de la enfermedad de Alzheimer." Doctoral thesis, Universitat Autònoma de Barcelona, 2005. http://hdl.handle.net/10803/5398.

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La enfermedad de Alzheimer (EA) es la enfermedad neurodegenerativa más común entre las demencias existentes hoy en día, cursando con alteraciones cognitivas y neuropsiquiátricas. Durante el proceso normal de envejecimiento existe un declive de las funciones sensoriales y motoras, acompañado de una disfunción cognitiva leve. Sin embargo, la demencia comprende un grupo de disfunciones caracterizadas por un deterioro gradual de las habilidades intelectuales, hasta el punto de originar graves problemas sociales. La prevalencia de los casos de demencia en personas de más de 80 años es de aproximada
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Gissi, Danilo Soares. "Phylogeny of Phlegmariurus (Lycopodiaceae) focusing on Brazilian endemic species." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/41/41132/tde-18052017-150806/.

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Phlegmariurus is the most abundant genus of Lycopodiaceae in Brazil with 40 species, 24 of which are endemic, occurring mainly in the Atlantic Rainforest and Rocky Fields (“Campos Rupestres”) in the Espinhaço range. Some phylogeny works with the group had already been carried out, but not including a representative sample of the Brazilian species. Thus, we performed a molecular phylogeny of Phlegmariurus species endemic in Brazil using three molecular markers of cpDNA. Phlegmariurus showed to be monophyletic, including two clades, one Neotropical and another Paleotropical. All the
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Caprio, Vittorio. "A convergent approach to huperzine A." Thesis, University of Reading, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389646.

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Lucey, Cathal Daniel. "Synthesis of Huperzine A and analogues." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485064.

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Huperzine A is a natural product, originally isolated from the Chinese club moss Huperzia serrata, which is currently undergoing clinical trials in the U.S. and has already been approved in China for the treatment of Alzheimer's disease (AD). This sesquiterpene alkaloid of the Lycopodium family is an eXGellent selective and reversible inhibitor of acetylcholinesterase (AChE), which is an established target in the palliative treatment of AD. Huperzine A has been the target of several syntheses and a number of analogues have also been prepared. However, all of the synthetic approaches to date ha
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Kessler, Eduardo. "Esporófito de Huperzia mandiocana (Raddi) Trevisan (Lycopodiaceae)." reponame:Repositório Institucional da UFSC, 2012. http://repositorio.ufsc.br/xmlui/handle/123456789/92913.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pos-Graduação em Biologia Vegetal, Florianópolis, 2009.<br>Made available in DSpace on 2012-10-24T13:55:42Z (GMT). No. of bitstreams: 1 279704.pdf: 4386601 bytes, checksum: f87d4af2dd04f85b67a27701d8b2ddbc (MD5)<br>Lycopodiaceae inclui quatro gêneros, Huperzia distingüe-se dos outros três gêneros por apresentar, entre outras características, caules ramificados isotomicamente e esporofilos semelhantes às folhas vegetativas. Huperzia mandiocana é uma epífita ocorrente nas florestas dos Est
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Kelly, S. A. "A convergent approach to huperzine A and analogues." Thesis, Queen's University Belfast, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403166.

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Foricher, Yann. "A convergent synthesis of the skeleton of huperzine A and analogues." Thesis, University of Reading, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342106.

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Books on the topic "Huperzina A"

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Bagchi, Debasis, Jean Barilla, and Bagchi D. Huperzine A: Boost Your Brain Power. McGraw-Hill, 1999.

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Huperzine A: What You Need to Know. Avery, 1999.

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Book chapters on the topic "Huperzina A"

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Lian, Wen-Wen, Ai-Lin Liu, and Guan-Hua Du. "Huperzine A." In Natural Small Molecule Drugs from Plants. Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-8022-7_45.

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Hanin, Israel, Xi Can Tang, and Alan P. Kozikowski. "Clinical and Preclinical Studies with Huperzine." In Cholinergic Basis for Alzheimer Therapy. Birkhäuser Boston, 1991. http://dx.doi.org/10.1007/978-1-4899-6738-1_32.

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Tang, Xi Can, Zhi Qi Xiong, Bo Chu Qian, Zhi Fang Zhou, and Ci Lu Zhang. "Cognition Improvement by Oral Huperzine A: A Novel Acetylcholinesterase Inhibitor." In Alzheimer Disease. Birkhäuser Boston, 1994. http://dx.doi.org/10.1007/978-1-4615-8149-9_20.

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Bhatnagar, Somika, Yuan Qing Deborah Hong, Guang Yuan Wang, and Yan Hong. "In Vivo and In Vitro Studies on Huperzine A Producing Ferns." In Biotechnology and Sustainable Agriculture 2006 and Beyond. Springer Netherlands, 2007. http://dx.doi.org/10.1007/978-1-4020-6635-1_63.

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Han, Yifan, and Xican Tang. "Preclinical and Clinical Progress with Huperzine A: A Novel Acetylcholinesterase Inhibitor." In Alzheimer Disease. Birkhäuser Boston, 1997. http://dx.doi.org/10.1007/978-1-4612-4116-4_36.

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Saxena, Ashima, Alan P. Kozikowski, Shaomeng Wang, Giuseppe Campiani, Qingjie Ding, and B. P. Doctor. "Characterization of C-10 Substituted Analogues of Huperzine A as Inhibitors of Cholinesterases." In Advances in Behavioral Biology. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5337-3_85.

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Orhan, Ilkay Erdogan, and F. Sezer Senol. "Alkaloids and Inhibitory Effects Against Enzymes Linked to Neurodegenerative Diseases (Physostigmine, Galanthamine, Huperzine, etc.)." In Natural Products. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-22144-6_23.

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Ved, H. S., J. M. Best, J. R. Dave, and B. P. Doctor. "Comparative Inhibition of Acetylcholinesterase by Tacrine, Physostigmine and Huperzine in the Adult Rat Brain." In Enzymes of the Cholinesterase Family. Springer US, 1995. http://dx.doi.org/10.1007/978-1-4899-1051-6_102.

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Silman, Israel, Michal Harel, Mia Raves, and Joel L. Sussman. "Crystallographic Studies on Complexes of Acetylcholinesterase with the Natural Cholinesterase Inhibitors Fasciculin and Huperzine A." In Advances in Behavioral Biology. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5337-3_75.

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Zhu, Da-Yuan, Chang-Heng Tan, and Yi-Ming Li. "The Overview of Studies on Huperzine A: A Natural Drug for the Treatment of Alzheimer's Disease." In Medicinal Chemistry of Bioactive Natural Products. John Wiley & Sons, Inc., 2006. http://dx.doi.org/10.1002/0471739340.ch4.

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Reports on the topic "Huperzina A"

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Myers, Todd M., Wei Sun, Ashima Saxena, Bhupendra P. Doctor, Andrew J. Bonvillain, and Matthew G. Clark. Huperzine A: Behavioral and Pharmacological Evaluation in Rhesus Monkeys. Defense Technical Information Center, 2008. http://dx.doi.org/10.21236/ada501469.

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