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Journal articles on the topic 'Huperzina A'

Author: Grafiati

Published: 4 June 2021

Last updated: 17 February 2022

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1

Xu, Maonian, Starri Heidmarsson, Margret Thorsteinsdottir, et al. "Infraspecific Variation of Huperzine A and B in Icelandic Huperzia selago Complex." Planta Medica 85, no. 02 (2018): 160–68. http://dx.doi.org/10.1055/a-0752-0295.

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AbstractThe alkaloids huperzine A and huperzine B were originally isolated from the Chinese club moss Huperzia serrata. They are known inhibitors of acetylcholinesterase, and especially huperzine A shows pharmaceutical potential for the treatment of Alzheimerʼs disease. Its supply heavily relies on natural plant sources belonging to the genus Huperzia, which shows considerable interspecific huperzine A variations. Furthermore, taxonomic controversy remains in this genus, particularly in the Huperzia selago group. With focus on Icelandic H. selago taxa, we aimed to explore the relatedness of Hu

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2

Ngọc, Vũ Thị, Phạm Thị Hạnh, Lê Thị Lan Anh, Nguyễn Tiến Đạt, and Lê Thị Bích Thủy. "Qualification and quantification of huperzine a from Huperia serrata in Da Lat, Lam Dong province." Vietnam Journal of Biotechnology 14, no. 3 (2016): 473–78. http://dx.doi.org/10.15625/1811-4989/14/3/9861.

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Huperzine A, an alkaloid, was originally isolated from Huperzia serrata. This compound potentially enhances the memory in animal, hence, it has been approved as a drug for the clinical treatment of Alzheimer’s disease, a major disease affecting the elderly population throughout the world. Because Huperzine A is an acetylcholinesterase inhibitor, the presentation of Huperzine A in brain inhibited acetylcholinesterase activity, thus, leading to the increase in concentration of acetylcoline. In Vietnam, H. serrata distributed in Sapa (Lao Cai) and Da Lat (Lam Dong), this species provide valuable

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3

Patočka, Jiří. "Huperzine A - An Interesting Anticholinesterase Compound from the Chinese Herbal Medicine." Acta Medica (Hradec Kralove, Czech Republic) 41, no. 4 (1998): 155–57. http://dx.doi.org/10.14712/18059694.2019.181.

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Huperzine A, alkaloid from the Chinese herbal medicine Qian Ceng Ta, which is prepared from the moss Huperzia serrata, has been used in China for centuries to treat fever and inflammation. Huperzine A is a strong inhibitor of cholinesterases with high selectivity to acetylcholinesterase and in China is developed as therapeutic against Alzheimer's disease. May be that huperzine A will be better than other centrally active anticholinesterases in treating this neurodegenerative disorder. Huperzine A appears to have additional pharmacological properties that make it an attractive candidate therapy

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4

Tan, Chang-Heng, Xiao-Qiang Ma, Guo-Fu Chen, and Da-Yuan Zhu. "Huperzines S, T, and U: New Lycopodium alkaloids from Huperzia serrata." Canadian Journal of Chemistry 81, no. 4 (2003): 315–18. http://dx.doi.org/10.1139/v03-067.

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Three new Lycopodium alkaloids, huperzines S (1), T (2), and U (3), along with eight known compounds, were isolated from the total alkaloids of the whole plant of Huperzia serrata (Thunb) Trev. (Huperziaceae). Those novel alkaloids were identified as 2β,13β-epoxyalopecuridine (1), 5α-hydroxy-6-oxodihydrophlegmariurine A (2), and 2,3-dihydro-12-hydroxyhuperzine B (3), respectively, by means of spectral techniques including NMR studies.Key words: Huperzia serrata, Lycopodium alkaloids, huperzines S, T, U.

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5

Nguyen, Ngoc Chuong, Dinh Vinh, Duc Tuan Nguyen, Huynh Van Thi Nguyen, Cong Luan Tran, and Manh Hung Tran. "Development of a Capillary Electrophoretic Method for the Determination of Huperzine A Concentration in Vietnamese Huperzia serrata." Natural Product Communications 16, no. 9 (2021): 1934578X2110332. http://dx.doi.org/10.1177/1934578x211033225.

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Huperzine A, isolated from Huperzia serrata, is a potent, specific, and reversible inhibitor of acetylcholinesterase with high efficiency and low toxicity. To evaluate the presence of huperzine A in Vietnamese H serrata, a reliable capillary zone electrophoresis method was developed. The analytical conditions were established using 80 mM ammonium acetate buffer, pH 6.0, hydrodynamic injection at 50 mbar for 5 s, applied voltage of 20 kV, temperature at 25 °C, uncoated fused-silica capillary, 56 cm (50 cm effective length) × 70 µm inner diameter, and ultraviolet detection at 310 nm. The recover

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6

Ma, Xiaoqiang, Changheng Tan, Dayuan Zhu, David R. Gang, and Peigen Xiao. "Huperzine A from Huperzia species—An ethnopharmacolgical review." Journal of Ethnopharmacology 113, no. 1 (2007): 15–34. http://dx.doi.org/10.1016/j.jep.2007.05.030.

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7

Zhang, Yanqing, Junbo Xie, Wen-Qian Chen, Tian-Yan Zhou, and Wei Lu. "Development of a Sensitive High-Performance Liquid Chromatographic Method with Simple Extraction for Simultaneous Determination of Huperzine A and Huperzine B in the Species Containing Lycopodium Alkaloids." Journal of AOAC INTERNATIONAL 92, no. 4 (2009): 1060–63. http://dx.doi.org/10.1093/jaoac/92.4.1060.

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Abstract A sensitive HPLC method with simple extraction was developed for simultaneous determination of huperzine A (HupA) and huperzine B (HupB) in Huperzia serrata, H. crispata, H. miyoshiana, and Lycopodiastrum casuarinoides. In order to avoid conventional multiple-step and time-consuming sample preparation methods, direct reflux extraction with alkaline chloroform was adopted. The quantitative determination was conducted by reversed-phase HPLC with a photodiode array detector set at 308 nm. Separation was performed on a Luna C18 column (250 4.6 mm id, 5 m) with methanol0.2 aqueous acetic a

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8

Tan, Chang-Heng, Shan-Hao Jiang, and Da-Yuan Zhu. "Huperzine P, a novel Lycopodium alkaloid from Huperzia serrata." Tetrahedron Letters 41, no. 30 (2000): 5733–36. http://dx.doi.org/10.1016/s0040-4039(00)00893-5.

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9

Goodger, Jason Q. D., Anne L. Whincup, Ashley R. Field, Joseph A. M. Holtum, and Ian E. Woodrow. "Variation in huperzine A and B in Australasian Huperzia species." Biochemical Systematics and Ecology 36, no. 8 (2008): 612–18. http://dx.doi.org/10.1016/j.bse.2008.05.006.

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10

Szypuła, Wojciech J., Beata Wileńska, Aleksandra Misicka, and Agnieszka Pietrosiuk. "Huperzine A and Huperzine B Production by Prothallus Cultures of Huperzia selago (L.) Bernh. ex Schrank et Mart." Molecules 25, no. 14 (2020): 3262. http://dx.doi.org/10.3390/molecules25143262.

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This is the first report of an efficient and effective procedure to optimize the biosynthesis of huperzine A (HupA) and huperzine B (HupB) in vitro from Huperzia selago gametophytes. Axenic tissue cultures were established using spores collected from the sporophytes growing in the wild. The prothalia were obtained after 7–18 months. Approximately 90 up to 100% of the gametophytes were viable and grew rapidly after each transfer on to a fresh medium every 3 months. The best biomass growth index for prothallus calculated on a fresh (FW) and dry weight (DW) basis, at 24 weeks of culture, was 2500

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11

Tan, Chang-Heng, Shan-Hao Jiang, and Da-Yuan Zhu. "ChemInform Abstract: Huperzine P, a Novel Lycopodium Alkaloid from Huperzia serrata." ChemInform 31, no. 44 (2000): no. http://dx.doi.org/10.1002/chin.200044218.

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12

Zhang, Zhi Bin, Qing Gui Zeng, Ri Ming Yan, Ya Wang, Zheng Rong Zou, and Du Zhu. "Endophytic fungus Cladosporium cladosporioides LF70 from Huperzia serrata produces Huperzine A." World Journal of Microbiology and Biotechnology 27, no. 3 (2010): 479–86. http://dx.doi.org/10.1007/s11274-010-0476-6.

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13

Dong, Li-Hui, San-Wei Fan, Qing-Zhi Ling, Bei-Bei Huang, and Zhao-Jun Wei. "Indentification of huperzine A-producing endophytic fungi isolated from Huperzia serrata." World Journal of Microbiology and Biotechnology 30, no. 3 (2013): 1011–17. http://dx.doi.org/10.1007/s11274-013-1519-6.

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14

Wang, Ya, Qing Gui Zeng, Zhi Bin Zhang, Ri Ming Yan, Ling Yun Wang, and Du Zhu. "Isolation and characterization of endophytic huperzine A-producing fungi from Huperzia serrata." Journal of Industrial Microbiology & Biotechnology 38, no. 9 (2010): 1267–78. http://dx.doi.org/10.1007/s10295-010-0905-4.

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15

Ying, You-Min, Yi-Lian Xu, Hang-Fei Yu, et al. "Biotransformation of Huperzine A by Irpex lacteus-A fungal endophyte of Huperzia serrata." Fitoterapia 138 (October 2019): 104341. http://dx.doi.org/10.1016/j.fitote.2019.104341.

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16

Shu, Shaohua, Xinmei Zhao, Wenjuan Wang, et al. "Identification of a novel endophytic fungus from Huperzia serrata which produces huperzine A." World Journal of Microbiology and Biotechnology 30, no. 12 (2014): 3101–9. http://dx.doi.org/10.1007/s11274-014-1737-6.

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17

Zhang, Hongchao, Hao Liang, Pengqun Kuang, Qipeng Yuan, and Yan Wang. "Simultaneously preparative purification of Huperzine A and Huperzine B from Huperzia serrata by macroporous resin and preparative high performance liquid chromatography." Journal of Chromatography B 904 (September 2012): 65–72. http://dx.doi.org/10.1016/j.jchromb.2012.07.019.

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18

Sun, Ye, Hua-Hong Chen, Hong-Min Sun, et al. "Naumannella huperziae sp. nov., an endophytic actinobacterium isolated from Huperzia serrata (Thunb.)." International Journal of Systematic and Evolutionary Microbiology 67, no. 6 (2017): 1867–72. http://dx.doi.org/10.1099/ijsem.0.001882.

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19

Zhu, D., J. Wang, Q. Zeng, Z. Zhang, and R. Yan. "A novel endophytic Huperzine A-producing fungus, Shiraia sp. Slf14, isolated from Huperzia serrata." Journal of Applied Microbiology 109, no. 4 (2010): 1469–78. http://dx.doi.org/10.1111/j.1365-2672.2010.04777.x.

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20

Ferreira, Ana, Márcio Rodrigues, Ana Fortuna, Amílcar Falcão, and Gilberto Alves. "Huperzine A from Huperzia serrata: a review of its sources, chemistry, pharmacology and toxicology." Phytochemistry Reviews 15, no. 1 (2014): 51–85. http://dx.doi.org/10.1007/s11101-014-9384-y.

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21

Le, Thanh Thi Minh, Anh Thi Hong Hoang, Nhue Phuong Nguyen, et al. "A novel huperzine A-producing endophytic fungus Fusarium sp. Rsp5.2 isolated from Huperzia serrate." Biotechnology Letters 42, no. 6 (2020): 987–95. http://dx.doi.org/10.1007/s10529-020-02836-x.

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22

Yang, Yan, Liangfang Dai, Decai Wu, et al. "In Vitro Propagation, Huperzine A Content and Antioxidant Activity of Three Genotypic Huperzia serrata." Plants 10, no. 6 (2021): 1112. http://dx.doi.org/10.3390/plants10061112.

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Huperzia serrata is a traditional herb and endangered Chinese medicinal material, which has attracted much attention due to its production of Huperzine A (HupA). In vitro propagation of H. serrata is considered a new way to relieve the resource pressure of H. serrata. In this study, three different genotypic wild H. serrata were used for in vitro propagation. Then, the antioxidant activity and the content of HupA in the regenerated H. serrata were investigated. The results showed the survival rate of the explant was increased to 25.37% when using multiple sterilization processes. The best indu

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23

ZHANG, Jingcai, Jie WEI, Hongmin ZHONG, Zhimou GUO, and Hua ZHANG. "Determination of Huperzine A in the extract of Huperzia serrata by high performance liquid chromatography." Chinese Journal of Chromatography 31, no. 1 (2013): 79. http://dx.doi.org/10.3724/sp.j.1123.2012.08038.

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24

Ying, You-Min, Wei-Guang Shan, and Zha-Jun Zhan. "Biotransformation of Huperzine A by a Fungal Endophyte of Huperzia serrata Furnished Sesquiterpenoid–Alkaloid Hybrids." Journal of Natural Products 77, no. 9 (2014): 2054–59. http://dx.doi.org/10.1021/np500412f.

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25

Szypuła, Wojciech, Agnieszka Pietrosiuk, Piotr Suchocki, Olga Olszowska, Mirosława Furmanowa, and Olga Kazimierska. "Somatic embryogenesis and in vitro culture of Huperzia selago shoots as a potential source of huperzine A." Plant Science 168, no. 6 (2005): 1443–52. http://dx.doi.org/10.1016/j.plantsci.2004.12.021.

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26

Toribio, Alix, Eldra Delannay, Bernard Richard, et al. "Preparative isolation of huperzines A and B from Huperzia serrata by displacement centrifugal partition chromatography." Journal of Chromatography A 1140, no. 1-2 (2007): 101–6. http://dx.doi.org/10.1016/j.chroma.2006.11.065.

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27

Yu, Lijun, Yunfeng Shi, Jianan Huang, Yushun Gong, Zhonghua Liu, and Weixin Hu. "Modification and Validation of a High-Performance Liquid Chromatography Method for Quantification of Huperzine A in Huperzia Crispata." Journal of AOAC INTERNATIONAL 93, no. 5 (2010): 1428–35. http://dx.doi.org/10.1093/jaoac/93.5.1428.

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Abstract The present study describes a rapid and sensitive HPLC method for the quantification of huperzine A (HupA) in Huperzia Crispata (Huperziaceae). The sample extraction and preparation involved a simple, time-saving, single-solvent extraction, with each sample being analyzed within 12 min. The mobile phase was ammonium acetate (0.1 M, pH 6.0)methanol (64 + 36, v/v) at a flow rate of 1.0 mL/min. Detection was at 308 nm. The calibration curve was linear from 0.049 to 7.84 µg (R2 = 0.9997), with intraday and interday precision RSD of less than 2%. The extraction recovery rate was over 98.49

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28

Ishiuchi, Kan’ichiro, Jeong-Jin Park, Robert M. Long, and David R. Gang. "Production of huperzine A and other Lycopodium alkaloids in Huperzia species grown under controlled conditions and in vitro." Phytochemistry 91 (July 2013): 208–19. http://dx.doi.org/10.1016/j.phytochem.2012.11.012.

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29

Cuthbertson, Daniel, Jasenka Piljac-Žegarac, and Bernd Markus Lange. "Validation of a microscale extraction and high-throughput UHPLC-QTOF-MS analysis method for huperzine A in Huperzia." Biomedical Chromatography 26, no. 10 (2012): 1191–95. http://dx.doi.org/10.1002/bmc.2677.

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30

Ho, Raimana, Niloufar Marsousi, Philippe Eugster, Jean-Pierre Bianchini, and Phila Raharivelomanana. "Detection by UPLC/ESI-TOF-MS of Alkaloids in Three Lycopodiaceae Species from French Polynesia and Their Anticholinesterase Activity." Natural Product Communications 4, no. 10 (2009): 1934578X0900401. http://dx.doi.org/10.1177/1934578x0900401007.

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Three Lycopodiaceae species from French Polynesia, Lycopodium venustulum C. Gaudichaud, Lycopodiella cernua (C. Linnaeus) R. E. Pichi Sermolli and Lycopodium henryanum E. D. Brown were investigated for their alkaloidal composition by UHPLC/ESI-TOF-MS. Ten alkaloids were identified, with lycopodine and lycodoline being the main constituents in the three species. The acetylcholinesterase-inhibitory activities of the three species are probably due to the occurrence of huperzine A, huperzine B, huperzine E, huperzinine and lycopodine.

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31

Kong, Xiang-Peng, Etta Y. L. Liu, Zhi-Cong Chen, et al. "Synergistic Inhibition of Acetylcholinesterase by Alkaloids Derived from Stephaniae Tetrandrae Radix, Coptidis Rhizoma and Phellodendri Chinensis Cortex." Molecules 24, no. 24 (2019): 4567. http://dx.doi.org/10.3390/molecules24244567.

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Alkaloids having acetylcholinesterase (AChE) inhibitory activity are commonly found in traditional Chinese medicine (TCM); for example, berberine from Coptis chinensis, galantamine from Lycoris radiata, and huperzine A from Huperzia serrata. In practice of TCM, Stephaniae Tetrandrae Radix (STR) is often combined with Coptidis Rhizoma (CR) or Phellodendri Chinensis Cortex (PCC) as paired herbs during clinical application. Fangchinoline from STR and coptisine and/or berberine from CR and/or PCC are active alkaloids in inhibiting AChE. The traditional usage of paired herbs suggests the synergisti

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32

Ayer, William A., Lois M. Browne, Helena Orszanska, Zdenek Valenta, and Jia-Sen Liu. "Alkaloids of Lycopodiumselago. On the identity of selagine with huperzine A and the structure of a related alkaloid." Canadian Journal of Chemistry 67, no. 10 (1989): 1538–40. http://dx.doi.org/10.1139/v89-234.

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Selagine, an alkaloid of Lycopodiumselago, is shown to be identical with huperzine A (2). A minor alkaloid, C15H18N2O2, isolated from L. selago is found to be 6β-hydroxyhuperzine A (4). Keywords: huperzine A, selagine, Lycopodium alkaloids, Alzheimer's disease, acetylcholine esterase inhibitor.

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33

Cui, Lingli, Hamza Armghan Noushahi, Yipeng Zhang, et al. "Endophytic Fungal Community of Huperzia serrata: Diversity and Relevance to the Production of Huperzine A by the Plant Host." Molecules 26, no. 4 (2021): 892. http://dx.doi.org/10.3390/molecules26040892.

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As the population ages globally, there seem to be more people with Alzheimer’s disease. Unfortunately, there is currently no specific treatment for the disease. At present, Huperzine A (HupA) is one of the best drugs used for the treatment of Alzheimer’s disease and has been used in clinical trials for several years in China. HupA was first separated from Huperzia serrata, a traditional medicinal herb that is used to cure fever, contusions, strains, hematuria, schizophrenia, and snakebite for several hundreds of years in China, and has been confirmed to have acetylcholinesterase inhibitory act

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34

Chương, Nguyễn Ngọc. "THIẾT LẬP CHẤT CHUẨN VÀ ĐỊNH LƯỢNG HUPERZIN A TRONG MỘT SỐ LOÀI HỌ THẠCH TÙNG Ở VIỆT NAM". Vietnam Journal of Science and Technology 54, № 2C (2018): 417. http://dx.doi.org/10.15625/2525-2518/54/2c/11870.

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Huperzin A được phân lập lần đầu tiên từ loài Thạch tùng răng và có tác dụng ức chếacetylcholinesterase. Thiết lập chất chuẩn Huperzin A với độ tinh khiết 99,13 % đã được thực hiệnlà rất cần thiết để làm chất đối chiếu trong kiểm nghiệm đánh giá chất lượng các dược liệu. Quytrình định tính và định lượng bằng phương pháp HPLC được xây dựng và thẩm định đạt yêu cầuđể ứng dụng phân tích hàm lượng huperzin A trong 10 loài thuộc họ Thạch tùng ở Việt Nam.

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35

Wen-Xia, Han, Han Zhong-Wen, Jia Min, et al. "Five novel and highly efficient endophytic fungi isolated from Huperzia serrata expressing huperzine A for the treatment of Alzheimer’s disease." Applied Microbiology and Biotechnology 104, no. 21 (2020): 9159–77. http://dx.doi.org/10.1007/s00253-020-10894-4.

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36

&NA;. "Huperzine A." Drugs in R & D 5, no. 1 (2004): 44–45. http://dx.doi.org/10.2165/00126839-200405010-00009.

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37

Pepping, Joseph. "Huperzine A." American Journal of Health-System Pharmacy 57, no. 6 (2000): 530–34. http://dx.doi.org/10.1093/ajhp/57.6.530.

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38

Ji, R. "Huperzine A." Drugs of the Future 12, no. 6 (1987): 531. http://dx.doi.org/10.1358/dof.1987.012.06.55104.

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39

Ding, Rui, Jian-Guo Fu, Guang-Qiang Xu, Bing-Feng Sun, and Guo-Qiang Lin. "Divergent Total Synthesis of the Lycopodium Alkaloids Huperzine A, Huperzine B, and Huperzine U." Journal of Organic Chemistry 79, no. 1 (2013): 240–50. http://dx.doi.org/10.1021/jo402419h.

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40

Sun, Rui, Si Hao Chen, and Chen Chen Xing. "Fixed Speed Release System: Huperzine a Loaded Microspheres in Thermosensitive Methylcellulose Based Hydrogel." Advanced Materials Research 236-238 (May 2011): 2491–94. http://dx.doi.org/10.4028/www.scientific.net/amr.236-238.2491.

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Huperzine A loaded microspheres are prepared using a W/O solvent evaporation method. The fixed speed release system is that microspheres composed with thermosensitive methylcellulose based hydrogel. SEM is used to analysis the surface morphology of Huperzine A loaded microspheres, which is shown that the difference of the size of microspheres. The size less than 200µm can be used as injection. Gelation experiment shows that the methylcellulose based solution can be transformed into in-situ hydrogel in 15 minutes at body temperature. The result of in vitro release shows that Huperzine A release

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41

Wang, Zhi-Yong, Jian-Gang Liu, Hao Li, and Hui-Ming Yang. "Pharmacological Effects of Active Components of Chinese Herbal Medicine in the Treatment of Alzheimer's Disease: A Review." American Journal of Chinese Medicine 44, no. 08 (2016): 1525–41. http://dx.doi.org/10.1142/s0192415x16500853.

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Alzheimer's disease (AD), the most common neurodegenerative disorder associated with dementia, not only severely decreases the quality of life for its victims, but also brings a heavy economic burden to the family and society. Unfortunately, few chemical drugs designed for clinical applications have reached the expected preventive or therapeutic effect so far, and combined with their significant side-effects, there is therefore an urgent need for new strategies to be developed for AD treatment. Traditional Chinese Medicine has accumulated many experiences in the treatment of dementia during th

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42

Szypuła, Wojciech J., Paulina Mistrzak, and Olga Olszowska. "A new and fast method to obtain in vitro cultures of Huperzia selago (Huperziaceae) sporophytes, a club moss which is a source of huperzine A." Acta Societatis Botanicorum Poloniae 82, no. 4 (2013): 313–20. http://dx.doi.org/10.5586/asbp.2013.034.

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This study presents a protocol for a fast and effective in vitro axenic culture of <em>Huperzia selago</em> (Huperziaceae Rothm.) sporophytes, a club moss which is a source of huperzine A, an alkaloid of a considerable therapeutic potential extensively investigated for its uses as treatment for some neurodegenerative diseases. The proposed procedure allowed approximately tenfold shortening of the species developmental stages with the omission of the gametophyte stage while the sporophyte mass could be increased tenfold within a 6-month period. The cultures were established using ve

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43

ARANA, MARCELO D. "Nomenclatural notes on Phlegmariurus dentatus (Lycopodiaceae)." Phytotaxa 252, no. 4 (2016): 298. http://dx.doi.org/10.11646/phytotaxa.252.4.8.

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The Lycopodiaceae comprise 16 monophyletic genera grouped into three subfamilies (Arana & Øllgaard 2012, Øllgaard 2012, 2014). One of the recently resurrected genera is Phlegmariurus Holub (1964: 21) with ca. 400 species formerly treated under Huperzia Bernhardi (1801: 126) in the Neotropics and Palaeotropics, leaving Huperzia s.s. with 15–25 species restricted to the Holarctic and austral Andean regions (Arana & Øllgaard 2012).

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44

Peng, Qing-Zhong, Hua Long, Ci Du, Jing Li, and De-Yu Xie. "RNA-seq of aboveground sporophyte’s transcriptome of Huperzia serrata and transcriptional understanding of early steps associated with huperzine biosynthesis in forest." Current Plant Biology 24 (December 2020): 100159. http://dx.doi.org/10.1016/j.cpb.2020.100159.

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45

Hu, Xiao-na, Jiao-feng Wang, Yi-qin Huang, et al. "Huperzine A attenuates nonalcoholic fatty liver disease by regulating hepatocyte senescence and apoptosis: an in vitro study." PeerJ 6 (June 26, 2018): e5145. http://dx.doi.org/10.7717/peerj.5145.

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Objective This study was undertaken to detect if free fatty acids (FFA) induce hepatocyte senescence in L-02 cells and if huperzine A has an anti-aging effect in fatty liver cells. Methods L-02 cells were treated with a FFA mixture (oleate/palmitate, at 3:0, 2:1, 1:1, 1:2 and 0:3 ratios) at different concentrations. Cell viability and fat accumulation rate were assessed by a Cell Counting Kit 8 and Nile Red staining, respectively. The mixture with the highest cell viability and fat accumulation rate was selected to continue with the following experiment. The L-02 cells were divided into five g

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Thu Ha, Tran Thi, Tran Dang Khanh, and Khuat Huu Trung. "Evaluation of Genetic Diversity and Identification of Huperzia Species Collected in Some Different Areas in Vietnam by Molecular Markers." International Letters of Natural Sciences 80 (December 2020): 13–23. http://dx.doi.org/10.18052/www.scipress.com/ilns.80.13.

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The objective of this study was to evaluate genetic diversity of 35 Huperzia samples collected from the different ecological areas in Vietnam by using rbcL markers. The results revealed that the samples were genetically diverse in high genetic similarity which ranged from 98.0 to 99.0%, respectively. Based on the Genbank data in comparison, it was ascertained that only one sample (BK3) is a member of H.phlegmarioides group, and others belonged H. squarrosa group as divided into two main groups by phylogenetic tree analyses. It suggests that some Huperzia samples may plausibly descend from the

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Gong, Zhi-Lian, Meng-Jie Ai, Hong-Min Sun, Hong-Yu Liu, Li-Yan Yu, and Yu-Qin Zhang. "Jatrophihabitans huperziae sp. nov., an endophytic actinobacterium isolated from surface-sterilized tissue of the medicinal plant Huperzia serrata (Thunb.)." International Journal of Systematic and Evolutionary Microbiology 66, no. 10 (2016): 3972–77. http://dx.doi.org/10.1099/ijsem.0.001296.

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Yang, Yuhang, Hua Wang, Haixia Yu, et al. "Simultaneous separation and determination of three huperzine alkaloids in Huperzia serrata and its preparations by cyclodextrin-modified mixed micellar electrokinetic capillary chromatography." Analytical Biochemistry 623 (June 2021): 114207. http://dx.doi.org/10.1016/j.ab.2021.114207.

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Johns, R. J. "HUPERZIA PINIFOLIA Lycopodiaceae." Curtis's Botanical Magazine 8, no. 3 (1991): 123–28. http://dx.doi.org/10.1111/j.1467-8748.1991.tb00373.x.

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Thorroad, Sakornrat, Prateep Worawittayanont, Nisachon Khunnawutmanotham, et al. "Three new Lycopodium alkaloids from Huperzia carinata and Huperzia squarrosa." Tetrahedron 70, no. 43 (2014): 8017–22. http://dx.doi.org/10.1016/j.tet.2014.08.042.

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