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Journal articles on the topic 'Hydrazide-Hydrazone'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Shalini, Agarwal, and Goyal Anju. "Exploring the Therapeutic Potential of Hydrazide-Hydrazone Derivatives: A Comprehensive Review." Pharmaceutical and Chemical Journal 7, no. 3 (2020): 100–107. https://doi.org/10.5281/zenodo.13954554.

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The exploration of novel compounds with antibacterial, anticancer, and anticonvulsant activities is a significant area of research due to the rising challenges posed by drug-resistant bacterial strains, cancer, and neurological disorders. The continual rise of drug-resistant bacterial strains, the complex challenges associated with cancer, and the persistent enigma of neurological disorders have fueled an ongoing quest for innovative therapeutic agents. Among the myriad compounds under investigation, hydrazide-hydrazone derivatives have emerged as promising candidates with diverse biological a

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2

Prateeptongkum, Saisuree, Nongnaphat Duangdee, and Wiratchanee Mahavorasirikul. "Evaluation of Cytotoxicity and Apoptosis Induced by Coumarin Hydrazide-Hydrazone Derivatives in Human Hepatocellular Carcinoma Cell Line." Trends in Sciences 21, no. 7 (2024): 7628. http://dx.doi.org/10.48048/tis.2024.7628.

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Coumarin and aryl hydrazide-hydrazone have attracted our attention due to their vast biological properties. Previous studies suggested that coumarin-tethered aryl hydrazide-hydrazone showed potent activities against HepG2. In the present study, we investigated the cytotoxic potency of the coumarin derivatives 1 - 3 to compare with coumarin hydrazine-hydrazone hybrids 4 and 5 against hepatocellular carcinoma HepG2 and LH86 cell lines. Among the tested coumarins, hybrids 4 and 5 showed highly potent activity against HepG2 with IC50 values of 17.82 ± 2.79 and 7.87 ± 0.88 𝜇g/mL, respectively. The

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3

Fatullayeva, P. A. "COMPLEXES OF METALS WITH HYDRAZONE HYDRAZIDE SALICYLIC ACID." Chemical Problems 19, no. 2 (2021): 79–83. http://dx.doi.org/10.32737/2221-8688-2021-2-79-83.

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Complexes of Cu (II), Ni (II), and Co (II) with hydrazone derivatives of salicylic acid hydrazide and 3,5-di-tert-butyl salicylic aldehyde (LH) were synthesized and the structure of these compounds studied by means of elemental analysis methods, IR and electronic spectroscopy, magnetochemistry and thermal analysis. It revealed that the complexes are monomeric and have a composition [MLXSoI] where M is a metal ion, L is a ligand, X is an inorganic anion, and Sol is a solvent molecule. LH- in the complexes behaves like a monoanionic tridentate ligand. It found that the resulting complexes exhibi

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4

Mateev, Emilio, Muhammed Tilahun Muhammed, Ali Irfan, Shubham Sharma, Maya Georgieva, and Alexander Zlatkov. "Hydrazide-hydrazones as novel antioxidants - in vitro, molecular docking and DFT studies." Pharmacia 71 (October 16, 2024): 1–8. http://dx.doi.org/10.3897/pharmacia.71.e133114.

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The pathogenesis of many diseases, such as obesity, depression, cancer, cataract, and neurodegenerative diseases, is related to the generation of reactive oxygen species (ROS). Structures possessing radical-scavenging properties act as antioxidants and they could prevent the progression of the aforementioned diseases. Therefore, the current work was focused on the resynthesis and the antioxidant evaluation of 13 hydrazide-hydrazones. Two in vitro tests - DPPH and ABTS, were applied for the determination of the antioxidant capacities. The free-radical scavenging assays displayed that the hydraz

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5

Mateev, Emilio, Muhammed Muhammed Tilahun, Ali Irfan, Shubham Sharma, Maya Georgieva, and Alexander Zlatkov. "Hydrazide-hydrazones as novel antioxidants - in vitro, molecular docking and DFT studies." Pharmacia 71 (October 16, 2024): 1–8. https://doi.org/10.3897/pharmacia.71.e133114.

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The pathogenesis of many diseases, such as obesity, depression, cancer, cataract, and neurodegenerative diseases, is related to the generation of reactive oxygen species (ROS). Structures possessing radical-scavenging properties act as antioxidants and they could prevent the progression of the aforementioned diseases. Therefore, the current work was focused on the resynthesis and the antioxidant evaluation of 13 hydrazide-hydrazones. Two <i>in vitro</i> tests - DPPH and ABTS, were applied for the determination of the antioxidant capacities. The free-radical scavenging assays displayed that the

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6

Shaji, Neethu, Sandhya M J Nair, and Shaiju S Dharan. "Coumarin Hydrazide: Chemistry, Synthesis and Pharmacological Activities - A Review." International Journal of Research and Review 9, no. 12 (2022): 16–26. http://dx.doi.org/10.52403/ijrr.20221202.

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Coumarins are heterocyclic compound with a benzopyrone structure. Coumarins are a large group of organic compounds found in several plants even in bacteria and fungi. The biological activities of coumarins and its derivatives includes anticoagulant, anticancer, antiulcer, antifungal, anti-HIV, antimicrobial, antiosteoporosis, antioxidant and anti- inflammatory activity. Hydrazide-hydrazone derivatives act as structural sub units in many pharmacologically active compounds including coumarins to give biological activities like antimicrobial, anticancer, antifungal, anti-inflammatory, antiviral,

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7

Wu, Jiale, Jiafeng Wang, Yinglong Han, Yu Lin, Jing Wang, and Ming Bu. "Synthesis and Cytotoxic Activity of Novel Betulin Derivatives Containing Hydrazide-Hydrazone Moieties." Natural Product Communications 16, no. 10 (2021): 1934578X2110553. http://dx.doi.org/10.1177/1934578x211055345.

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A series of novel betulin derivatives containing hydrazide-hydrazone moieties were synthesized. All compounds were evaluated for their cytotoxicity against four human carcinoma cell lines (HepG2, A549, MCF-7 and HCT-116) and a normal human gastric epithelial cell line (GES-1). Among them, compound 6i was the most potent against HepG2 and MCF-7 cell lines, with IC50 values of 9.27 and 8.87 μM, respectively. The results suggest that the incorporation of a hydrazide-hydrazone side chain at the C-28 position of betulin is beneficial for compounds to display significant cytotoxicity. Compound 6i ma

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8

Gera, Ankur, Chander Mohan, and Sandeep Arora. "Synthesis of Phthaloylglycyl Hydrazide Derivatives: Selective Protection of Phthalimide Group from Hydrazinolysis." Current Organic Synthesis 15, no. 6 (2018): 839–45. http://dx.doi.org/10.2174/1570179415666180601083256.

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Background: N-phthalimide amino acid hydrazide is a class of compounds that have the potential therapeutic use. In general, hydrazinolysis of N-substituted amino acid(s) ester removes the ester group and yields the corresponding hydrazide. However, in case if N-substitution group is phthalimide, phthalimide group is cleaved and not the ester group. The resulted compound, therefore, is amino acid ester rather than Nphthalimide amino acid hydrazide. The above class of compounds, because of susceptibility of phthalimide group to hydrazinolysis, has previously been synthesized by a lengthy three-s

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9

Abd El-Salam, N. M., Z. Y. Al Shoaibi, and G. A. Ahmed. "Chemical Studies on 3,6-Dichloropyridazine (Part 2)." E-Journal of Chemistry 8, no. 4 (2011): 1944–50. http://dx.doi.org/10.1155/2011/612825.

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3,6-Dichloropyridazine (1) reacted with 2-aminophenol, phenylalanine, acetophenone hydrazone derivatives, acid hydrazide derivatives and amino-aromatic acids (anthranilic acid and 5-bromoanthranilic acid) and yield the compounds (2), (3), (4a,b), (5a,b) and (6a,b) respectively. Reaction of compounds (5a,b) with acid hydrazide gave (8a,b). Also, compounds (6a,b) reacted with aromatic amino acid and gave (7a-c).

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10

GOKLANI, POONAM, and ANIL GUPTA. "Synthesis, Structural Characterization and Study of Biological Activity of Hydrazine Derivatives." Material Science Research India 14, no. 2 (2017): 190–93. http://dx.doi.org/10.13005/msri/140217.

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Hydrazide-hydrazone derivatives play vital role in development of various pharmacological activities such as anti-tubercular, antiproliferative and antitumor activities. Some novel biologically active Hydrazide derivatives substituted with heterocyclic moiety have been synthesized. All the synthesized compounds structures were confirmed by IR, NMR and Mass spectra. Synthesized compounds were subjected to antibacterial screening in vitro and biological activity in vivo.

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11

Ünver, Hakan, Burak Berber, Rasime Demirel, and Ayşe T. Koparal. "Design, Synthesis, Anti-Proliferative, Anti-microbial, Anti-Angiogenic Activity and In Silico Analysis of Novel Hydrazone Derivatives." Anti-Cancer Agents in Medicinal Chemistry 19, no. 13 (2019): 1658–69. http://dx.doi.org/10.2174/1871520619666190318125824.

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Background: Cancer is the second leading cause of death globally. Hydrazone and hydrazone derivatives have high activity, and for this reason, these compound are greatly used by researchers to synthesize new anti-cancer drug. The aim of this research work is to synthesize novel anticancer agents. Methods: New hydrazone derivatives were synthesized via a reaction between 3-formylphenyl methyl carbonate and benzhydrazide, 4-methylbenzoic hydrazide, 4-tert-butylbenzoic hydrazide, 4-nitrobenzoic hydrazide and 3- methoxybenzoic hydrazide, and were successfully characterized using elemental analysis

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12

Thorat, B. R., S. N. Mali, Umang Shah, et al. "Hydrazide-Hydrazone Derivatives and Their Antitubercular Activity." Russian Journal of Bioorganic Chemistry 51, no. 1 (2025): 35–52. https://doi.org/10.1134/s1068162025010054.

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13

Agili, Fatimah. "Novel Hydrazide Hydrazone Derivatives as Antimicrobial Agents: Design, Synthesis, and Molecular Dynamics." Processes 12, no. 6 (2024): 1055. http://dx.doi.org/10.3390/pr12061055.

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Ester 2 was produced by reacting thiourea derivative 1 with ethyl 2-chloro-3-oxobutanoate in MeOH containing piperidine. Hydrazide 3 was produced by reacting the latter ester with hydrazine hydrate in EtOH at reflux. By reacting hydrazide 3 with aromatic/heterocyclic aldehydes, twelve derivatives of hydrazide hydrazone 5a–l were produced. Spectral measurements and elemental analysis verified the molecular structure. Compounds 2, 5a, 5c, 5d, and 5f had strong effects on all the pathogenic bacterial strains according to an evaluation of the antimicrobial qualities of the synthetic compounds. Wit

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14

Popiołek, Łukasz. "Updated Information on Antimicrobial Activity of Hydrazide–Hydrazones." International Journal of Molecular Sciences 22, no. 17 (2021): 9389. http://dx.doi.org/10.3390/ijms22179389.

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Hydrazide–hydrazones possess a wide spectrum of bioactivity, including antibacterial, antitubercular, antifungal, anticancer, anti-inflammatory, anticonvulsant, antidepressant, antiviral, and antiprotozoal properties. This review is focused on the latest scientific reports regarding antibacterial, antimycobacterial, and antifungal activities of hydrazide–hydrazones published between 2017 and 2021. The molecules and their chemical structures presented in this article are the most active derivatives, with discussed activities having a hydrazide–hydrazone moiety as the main scaffold or as a side

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15

Agarwal, Mahadev, Neelam Singla, and S. K. Singh. "Novel Synthesis, Physicochemical Characterization of 1,3,4-Oxadiazinoindole Derivatives for the Purpose of Antidepressant Activity." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 13, no. 03 (2023): 936–41. http://dx.doi.org/10.25258/ijddt.13.3.26.

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The present study synthesized a series of 1,3,4-oxadiazinoindole moiety-containing compounds by combining MAOI’s hydrazide moiety and tricyclic moiety having antidepressant activity. The formation of amino acid chloride from amino acids started the synthesis. Further, they were converted into amino acid hydrazide, and then amino acid hydrazones were prepared by reaction of amino acid hydrazide with isatin. Finally, cyclization was acted on hydrazone-containing compounds in the presence of cold H2SO4. Synthesized compounds are characterized and confirmed via mass spectroscopy, 1H-nuclear magnet

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16

Wang, Lingyun, Xianggen Chen, and Derong Cao. "A cyanide-selective colorimetric “naked-eye” and fluorescent chemosensor based on a diketopyrrolopyrrole–hydrazone conjugate and its use for the design of a molecular-scale logic device." RSC Advances 6, no. 99 (2016): 96676–85. http://dx.doi.org/10.1039/c6ra21669b.

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A novel diketopyrrolopyrrole (DPP)–hydrazone based receptor was designed and synthesized as a selective fluorescent and colorimetric chemosensor for cyanide in aqueous media via deprotonation between the hydrazide moiety of the probe and cyanide.

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17

Choi, Heekyoung, Misun Go, Yubin Cha, Yeonweon Choi, Ki-Young Kwon, and Jong Hwa Jung. "A facile method to fabricate hydrogels from DMSO polymer gels via solvent exchange." New Journal of Chemistry 41, no. 12 (2017): 4793–96. http://dx.doi.org/10.1039/c7nj00152e.

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A mixture of the bipyridine, phenyl and/or cyclohexanediamine-based building blocks 1, 2, and/or 3, having hydrazide, aldehyde or amine moieties, respectively, formed DMSO polymer gels by the hydrazone reaction under acidic conditions.

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18

Wardakhan, Wagnat Wahba, El-Sayed Nahed Nasser Eid, and Rafat Milad Mohareb. "Synthesis and anti-tumor evaluation of novel hydrazide and hydrazide-hydrazone derivatives." Acta Pharmaceutica 63, no. 1 (2013): 45–57. http://dx.doi.org/10.2478/acph-2013-0004.

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The reaction of cyclopentanone with cyanoacetylhydrazine gave 2-cyano-2-cyclopentylideneacetohydrazide (1). Treatment of compound 1 with elemental sulphur in the presence of triethylamine afforded 2-amino-5,6-dihydro- -4H-cyclopenta[b]thiophene-3-carbohydrazide (2), which in-turn formed the corresponding intermediate diazonium salt. The latter was coupled with either ethyl cyanoacetate or ethyl acetoacetate to form 2-cyano-2-(3-(hydrazinecarbonyl)- 5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)hydrazono) acetate (3) and ethyl 2-(2-(3-(hydrazinecarbonyl)-5,6-dihydro- 4H-cyclopenta[b]thiophen-2-yl)h

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19

Abidov, Musa T. "Pharmacological aspects of hydrazides and hydrazide derivatives." Health Promotion & Physical Activity 2, no. 3 (2017): 9–21. http://dx.doi.org/10.5604/01.3001.0010.7718.

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Intense search for new antimicrobials, including anti-tuberculosis drugs, is dictated by the phenomenon of bacterial multidrug resistance. Hydrazides are considered the key intermediate and valuable starting material for some novel biologically active compounds. Over 70% of recently reported synthetic hydrazide derivatives are evaluated for antimicrobial and/or antifungal activity. The most frequently applied hydrazide is an anti- tuberculosis drug isoniazid/isonicotinic acid hydrazide (NIH). Hydrazide chemicals are sharing a common functional group characterized by a nitrogen- to-nitrogen cov

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20

Heinemann, F. W., H. Hartung, H. Dehne, and A. Scheunemann. "Thiooxalic Acid 2-Amide-1-hydrazide-2-hydrazone." Acta Crystallographica Section C Crystal Structure Communications 51, no. 3 (1995): 442–45. http://dx.doi.org/10.1107/s0108270194005494.

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21

Doshi, Viralkumar Arvindbhai, and Yogesh S. Patel. "Novel Benzimidazole based Hydrazide-hydrazone Compounds: Synthesis, Characterization and Antimicrobial Assessment." Asian Journal of Chemistry 36, no. 8 (2024): 1793–802. http://dx.doi.org/10.14233/ajchem.2024.31484.

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This work presents a comprehensive study on the design, synthesis, spectral characterization and antimicrobial assessment of new hydrazide-hydrazone incorporated benzimidazole compounds (6a-p). The synthesis of these compounds (6a-p) involved the condensation of benzimidazole derivative, 4-(1-methyl-5-nitro-1H-benzo[d]imidazol-2-yl)butane hydrazide with substituted aromatic aldehydes, utilizing an efficient and environmentally benign synthetic route. The IR, NMR and mass spectrometry were among the spectroscopic methods used to characterize the novel synthesized substances to confirm their che

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22

Tzankova, Diana, Lily Peikova, and Maya Georgieva. "PRELIMINARY DETERMINATION OF HYDROLYTIC STABILITY OF A PYRROLE-BASED HYDRAZIDE AND ITS HYDRAZONE." CBU International Conference Proceedings 6 (September 25, 2018): 1192–98. http://dx.doi.org/10.12955/cbup.v6.1314.

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A validated UV/VIS method for preliminary determination of the chemical stability and stability in close to physiological conditions of a model pyrrole hydrazide and its corresponding derivative, bearing susceptible to hydrolysis hydrazone group was developed. The evaluated substances were subjected to the influence of a variety of pH medias, representing the main physiological values of 37°C and corresponding pH values in the stomach (pH 2.0), blood (pH 7.4) and small intestine (pH 9.0). The chemical stability at strong alkali media of pH 13.0 was also evaluated. The hydrazide was found to be

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23

Nora, Amer Hussien, Y. Hussien Hyffaa, and H. Abdulrahman Shaymaa. "Predictive biological activity of newly synthesized hydrazone compounds derived from indomethacin." Journal of Wildlife and Biodiversity 7, Special Issue (2023): 391–402. https://doi.org/10.5281/zenodo.10246323.

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New derivatives of hydrazone have been successfully created, specifically 2-(1-(Aryl)-5-methoxy-2-methyl-1H-indol-3-yl)-N'-(2-chlorobenzylidene) acetohydrazide. The transformation of Indomethacin ester into hydrazide was achieved through a reaction with hydrazine hydrate in absolute ethanol, followed by the reaction of the resulting hydrazide with aromatic aldehydes. The structures of these newly synthesized hydrazones were validated through IR, 1HNMR, and 13CNMR analyses. Each compound's energies were optimized by utilizing density functional theory (DFT) for theoretical calculations. By empl

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24

Ekram Abdullah Basheer, Kalid Matny Al-jaanaby, and Feras Shauki Al-joboury. "Synthesis a Number of Heterocyclic Compounds Derived From Levofloxacin." Tikrit Journal of Pure Science 20, no. 5 (2023): 84–95. http://dx.doi.org/10.25130/tjps.v20i5.1244.

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In this paper, the preparation a number of heterocyclic compounds five membered rings like oxadiazole, imidazolidine, thiozolidine, tetrazole, azetidine 2-on. Hydrazide (1) was synthesized from the reaction of levofloxacin with hydrazine hydrate. Hydrazone compounds (2-9) were synthesized from the reaction (1) with a number of aldehydes, and 3-acetyl-1,3,4-oxadiazol (10-17) was prepared from the reaction of hydrazones (2-9) with acetic anhydride, 5-oxo-2-aryl imadazoldine derivative (18-25) were prepared from the reaction of hydrazone derivatives (2-9) with glycine, while the reaction of hydra

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25

El-Essawy, Farag A., Wael A. El-Sayed, Sherif A. El-Kafrawy, Asmaa S. Morshedy, and Adel-H. Abdel-Rahman. "Anti-Hepatitis B Virus Activity of New 1,2,4-Triazol-2-yl- and 1,3,4-Oxadiazol-2-yl-2-pyridinone Derivatives." Zeitschrift für Naturforschung C 63, no. 9-10 (2008): 667–74. http://dx.doi.org/10.1515/znc-2008-9-1010.

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A number of 1,3,4-oxadiazole, 3 - 9, and 1,2,4-triazole derivatives, 13 - 15, were synthesized starting form the acid hydrazide 1. The 1,3,4-thiadiazole derivative 12 was prepared from the substituted phenylthiosemicarbazide derivative 11 by treatment with sulfuric acid. The aryl hydrazone derivatives 10a - c were synthesized by reaction of the hydrazide 1 with the corresponding ketones. The thioalkyl derivatives 16a - e were prepared by akylation of the thiol derivatives 3 and 13 with different alkylating agents. The newly synthesized compounds were tested for their anti-HBV activity and some

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26

Assoma, Amon, Affoué Bede, Patrick-Armand Achi, and Siomenan Coulibali. "Stability and Reactivity of Two Benzimidazole Hydrazide-Hydrazone Compounds: A Theoretical Study by DFT Method." International Journal of Computational and Theoretical Chemistry 12, no. 1 (2024): 10–17. http://dx.doi.org/10.11648/j.ijctc.20241201.12.

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This work contributes to theoretical chemistry’s knowledge of benzimidazole-hydrazide-hydrazone. Indeed, hydrazides-hydrazones-benzimidazoles have shown anticancer, antibacterial, antiparasitic activities, and many other activities. A benzimidazole-hydrazide-hydrazone compound can exhibit four conformers: E/Z synperiplanar (Esp, Zsp) and E/Z antiperiplanar (Eap, Zap). Studies have indicated that the prevalence of these compounds is attributed to their stability and their tendency to readily bind to DNA. A theoretical study with advanced methods would make it possible to evaluate the stability

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27

Wameed Raad Abd-allah and Khaled Mtani Al – Janabi. "Preparation and diagnosis of new picolinic acid derivatives." Tikrit Journal of Pure Science 23, no. 6 (2023): 101–10. http://dx.doi.org/10.25130/tjps.v23i6.679.

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In this study, a new series of heterocyclic rings derived from picolinic acid was prepared. The quaternary reaction of acid hydrazone with chloroacetyl chloride was intended to obtain the azitidine-2-on ring known as beta-lactam and the preparation of the seventh ring of acid hydrazone reaction with the anhydride and phthalic anhydride To obtain a 3.1-oxabine loop. The five-ring of the picolinic acid hydrazide reaction with CS2 was also destined to obtain a 4,3,1-oxadiazole-2-thaion ring. The new compounds were diagnosed using FT-IR techniques and resonance technique Nuclear Magnetic H-NMR and

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Tzankova, Diana, Lily Peikova, Stanislava Vladimirova, and Maya Georgieva. "Development and validation of RP-HPLC method for stability evaluation of model hydrazone, containing a pyrrole ring." Pharmacia 66, no. 3 (2019): 127–34. http://dx.doi.org/10.3897/pharmacia.66.e47035.

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RP-HPLC method with UV detection was developed and validated for determination of the chemical stability and stability in close to physiological conditions of a model pyrrole hydrazone ethyl 5-(4-bromophenyl)-1-(1-(2-(4-hydroxy-3-methoxybenzylidene) hydrazineyl)-4-methyl-1-oxopentan-2-yl)-2-methyl-1H-pyrrole-3-carboxylate (D_5d), containing susceptible to hydrolysis hydrazone group. The evaluated substance was subjected to the influence of a variety of pH , representing the main physiological values of 37°C and corresponding pH values in the stomach (pH 2.0), blood (pH 7.4) and small intestine

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Tzankova, Diana, Lily Peikova, Stanislava Vladimirova, and Maya Georgieva. "Development and validation of RP-HPLC method for stability evaluation of model hydrazone, containing a pyrrole ring." Pharmacia 66, no. (3) (2019): 127–34. https://doi.org/10.3897/pharmacia.66.e47035.

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RP-HPLC method with UV detection was developed and validated for determination of the chemical stability and stability in close to physiological conditions of a model pyrrole hydrazone ethyl 5-(4-bromophenyl)-1-(1-(2-(4-hydroxy-3-methoxybenzylidene) hydrazineyl)-4-methyl-1-oxopentan-2-yl)-2-methyl-1H-pyrrole-3-carboxylate (D_5d), containing susceptible to hydrolysis hydrazone group. The evaluated substance was subjected to the influence of a variety of pH , representing the main physiological values of 37°C and corresponding pH values in the stomach (pH 2.0), blood (pH 7.4) and small intestine

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30

Šedová, Petra, Radovan Buffa, Peter Šilhár, et al. "The effect of hydrazide linkers on hyaluronan hydrazone hydrogels." Carbohydrate Polymers 216 (July 2019): 63–71. http://dx.doi.org/10.1016/j.carbpol.2019.04.011.

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31

Nasr, Tamer, Samir Bondock, and Mahmoud Youns. "Anticancer activity of new coumarin substituted hydrazide–hydrazone derivatives." European Journal of Medicinal Chemistry 76 (April 2014): 539–48. http://dx.doi.org/10.1016/j.ejmech.2014.02.026.

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32

Nocheva, Hristina, Stanislava Vladimirova, Diana Tzankova, Lily Peikova, and Maya Georgieva. "Analgesic properties of newly synthesized N pyrrolyl hydrazide hydrazones." Tropical Journal of Pharmaceutical Research 22, no. 1 (2023): 121–27. http://dx.doi.org/10.4314/tjpr.v22i1.17.

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Purpose: To screen a series of newly synthesized N-pyrrolyl hydrazide hydrazones for analgesic activity via Paw-pressure (PP) test and hot plate test (HPT). Methods: The compounds newly synthesized through the classical Paal-Knor cyclization, N-pyrrolyl hydrazide-hydrazones were administered intraperitoneally at a dose of 20 mg/kg. Paw pressure and hot plate tests were applied to assess the analgesic properties. In addition, stress-induced analgesia with naloxone as a non-selective opioid receptor antagonist was performed. Results: The compound (DI-5g), containing an izatine carbon

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33

Shabeeb, Ihsan, Luay Al-Essa, Majed Shtaiwi, et al. "New Hydrazide-hydrazone Derivatives of Quinoline 3-Carboxylic Acid Hydrazide: Synthesis, Theoretical Modeling and Antibacterial Evaluation." Letters in Organic Chemistry 16, no. 5 (2019): 430–36. http://dx.doi.org/10.2174/1570178616666181227122326.

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A series of biologically active 3-quinoline carboxylic acid hydrazide-hydrazones has been synthesized from 3-quinoline carboxylic acid hydrazide and a variety of aldehydes, with moderate to good yields. The chemical structures of the new products were confirmed by elemental analysis, IR, and 1H NMR, 13C NMR spectral data. The structural and frontier molecular orbital (FMO) properties and the density functional theory (DFT) calculations were conducted for the new compounds. The new hydrazide-hydrazones exhibited low to moderate antibacterial activity against Staphylococcus aureus and Esherichia

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Shu, Zhang, Wang Longyu, Cao Pengzhang, Gu Xuefan, Zhang Huani, and Chen Gang. "Synthesis of New Hydrazone Compounds from Natural Grease and Investigation as Flow Improver for Crude Oil." Нефтехимия 63, no. 3 (2023): 354–62. http://dx.doi.org/10.31857/s0028242123030061.

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n this work, salicylaldehyde hydrazone (SAH), different from the traditional polymers, was synthesized from natural oils (castor, SAСH, rapeseed, SARH and soybean, SASH), hydrazine hydrate and salicylaldehyde. Firstly, natural grease reacts with hydrazine hydrate to produce hydrazide, and then salicylaldehyde reacts with hydrazide to synthesis salicylaldehyde hydrazone. In this work, SAH were evaluated as viscosity-reducers and pour point depressors for crude oil. The results show that the SAH can significantly reduce the pour point and viscosity of crude oil, with the increase of crude oil fl

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Mohd, Saleem, Sharma Mohita, Mahajan Simpy, N. Sheikh H., and L. Kalsotra B. "Cyano complexes of oxotungsten(IV) with aroyl hydrazone ligands." Journal of India Chemical Society Vol. 87, Nov 2010 (2010): 1385–89. https://doi.org/10.5281/zenodo.5805877.

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Department of Chemistry, University of Jammu, Jammu-180 006, Jammu & Kashmir, India <em>E-mail</em> : hnsheikh@rediffmail.com <em>Manuscript received 26 October 2009, revised 10 May 2010, accepted 17 May 2010</em> Reactions of K<sub>3</sub>Na[WO<sub>2</sub>(CN)<sub>4</sub>). 6H<sub>2</sub>O with aroyl hydrazone ligands namely benzoic acid[1-(furan-2- yl)methylene]hydrazide (BFMH), benzoic acid [(thlophene-2-yl)methylene]hydrazide (BTMH), benzoic acid[1-(thiophene- 2-yl)methyldenehydrazlde (BTEH), benzoic acid(phenylmethylene) hydrazide (BPMH) and benzoic acid[l-(anisol-3- yl)methylene

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Yates, Ronald L., and John A. Wenninger. "Fluorometric Determination of Benzylideneacetone in Fragrance Products by Liquid Chromatography with Post-Column Derivatization." Journal of AOAC INTERNATIONAL 71, no. 5 (1988): 965–67. http://dx.doi.org/10.1093/jaoac/71.5.965.

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Abstract A method is described for the liquid chromatographic (LC)-fluorometric determination of benzylideneacetone in fragrance products. Benzylideneacetone is first separated from other fragrance ingredients by LC and then reacted post-column with a methanolic solution of isonicotinic acid hydrazide and aluminum nitrate. The reactants are maintained at 65°C for about 1.5 min to quantitatively form the fluorescent isonicotinoyl hydrazone derivative of benzylideneacetone. The aluminum ion forms a complex with the hydrazone to enhance the fluorescence of the derivative. The amount of benzyliden

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Wu, Shouting, Xi Liang, Fang Luo, et al. "Synthesis, Crystal Structure and Bioactivity of Phenazine-1-carboxylic Acylhydrazone Derivatives." Molecules 26, no. 17 (2021): 5320. http://dx.doi.org/10.3390/molecules26175320.

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A phenazine-1-carboxylic acid intermediate was synthesized from the reaction of aniline and 2-bromo-3-nitro-benzoic acid. It was then esterified and reacted with hydrazine hydrate to afford phenazine-1-carboxylic hydrazine. Finally, 10 new hydrazone compounds 3a–3j were obtained by the condensation reaction of phenazine-1-carboxylic acid hydrazide and the respective aldehyde-containing compound. The structures were characterized by 1H and 13C NMR spectroscopy, MS and single crystal X-ray diffraction. The antitumor activity of the target compounds in vitro (HeLa and A549) was determined by thia

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Garifullin, Bulat F., Olga V. Andreeva, Irina Yu Strobykina, Vasiliy M. Babaev, and Vladimir E. Kataev. "Macrocyclic Derivatives of Diterpenoid Isosteviol with Hydrazide and Hydrazone Moieties." Macroheterocycles 6, no. 2 (2013): 184–91. http://dx.doi.org/10.6060/mhc130334k.

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Durgesh, Rudavath, Sreenivasulu Reddymasu, Rao Pinapati Srinivasa, and Ramesh Raju Rudraraju. "Synthesis and anticancer evaluation of indazole-aryl hydrazide-hydrazone derivatives." Journal of India Chemical Society Vol. 95, Apr 2018 (2018): 433–38. https://doi.org/10.5281/zenodo.5642515.

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Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar-522 510, Andhra Pradesh, India E-mail: rrraju1@gmail.com Department of Chemistry, University College of Engineering (Autonomous), Jawaharlal Nehru Technological University, Kakinada-533 003, Andhra Pradesh, India <em>Manuscript received 24 February 2018, revised 01 March 2018, accepted 02 March 2018</em> A new series of hydrazide-hydrazones linked between indazole and substituted benzaldehydes were designed, synthesized and evaluated for their cytotoxicity against four human cancer cell lines (HeLa, MDAMB- 231, MCF-7 and A5

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Lazić, M., Siniša Radulović, Tamara R. Todorović, D. M. Sladić, Ž. Tešić, and K. K. Andjelković. "Evaluation of Cytotoxic Activity of d-Metal Complexes with Hydrazone Ligands." Materials Science Forum 518 (July 2006): 513–18. http://dx.doi.org/10.4028/www.scientific.net/msf.518.513.

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Cytotoxic activity of four series of coordinated complexes of Zn(II) and Fe(II) with hydrazone/hydrazide ligands against HeLa and B16 cells was evaluated. The ligands N’,N'2- bis[(1E)-1-(2-pyridyl)ethylidene]ethanedihydrazide (H2L1) and N’,N'2-bis[(1E)-1-(2-pyridyl) ethylidene]propanedihydrazide (H2L2) and their Zn(II) complexes showed IC50 values in the low micromolar range, while the other ligands and complexes were less active or inactive.

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Ibtehal K. Abdullah and Meaad K. Buniya. "Preparation and Identification of some heterocyclic compounds from cyano compounds." Tikrit Journal of Pure Science 20, no. 5 (2023): 96–105. http://dx.doi.org/10.25130/tjps.v20i5.1245.

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This article included prepared cyano acetic acid hydrazid from interaction cyano ethylacetate with hydrate hydrazen, and interaction with 2- acytel thiophene and 2- acytelpyridine it will formation of hydrazide- hydrazone derivative (I, II), and through the undergo the compounds (I,II) for chain of interactions with different chemical materials then enclosed cyclo formed derivative of (arylidene ,coumarin , aryl hydrazon , thiophene ) . Prepared compounds have been studied and Identification by physical and spectral means.

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Gavara, Laurent, Federica Verdirosa, Alice Legru та ін. "4-(N-Alkyl- and -Acyl-amino)-1,2,4-triazole-3-thione Analogs as Metallo-β-Lactamase Inhibitors: Impact of 4-Linker on Potency and Spectrum of Inhibition". Biomolecules 10, № 8 (2020): 1094. http://dx.doi.org/10.3390/biom10081094.

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To fight the increasingly worrying bacterial resistance to antibiotics, the discovery and development of new therapeutics is urgently needed. Here, we report on a new series of 1,2,4-triazole-3-thione compounds as inhibitors of metallo-β-lactamases (MBLs), which represent major resistance determinants to β-lactams, and especially carbapenems, in Gram-negative bacteria. These molecules are stable analogs of 4-amino-1,2,4-triazole-derived Schiff bases, where the hydrazone-like bond has been reduced (hydrazine series) or the 4-amino group has been acylated (hydrazide series); the synthesis and ph

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Witusik-Perkowska, Monika, Pola Głowacka, Adam M. Pieczonka, et al. "Autophagy Inhibition with Chloroquine Increased Pro-Apoptotic Potential of New Aziridine-Hydrazide Hydrazone Derivatives against Glioblastoma Cells." Cells 12, no. 14 (2023): 1906. http://dx.doi.org/10.3390/cells12141906.

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Tumor therapy escape due to undesired side effects induced by treatment, such as prosurvival autophagy or cellular senescence, is one of the key mechanisms of resistance that eventually leads to tumor dormancy and recurrence. Glioblastoma is the most frequent and practically incurable neoplasm of the central nervous system; thus, new treatment modalities have been investigated to find a solution more effective than the currently applied standards based on temozolomide. The present study examined the newly synthesized compounds of aziridine–hydrazide hydrazone derivatives to determine their ant

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Kulabas, Necla, Fahrettin Bugra Kilic, and Sevil Senkardes. "Investigations of Some Chlorocresol Hydrazones Against Tyrosinase Enzyme by Molecular Docking Method: In Silico Study." Pharmedicine Journal 2, no. 1 (2025): 16–23. https://doi.org/10.62482/pmj.23.

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Introduction: Tyrosinase, found in various organisms, including plants and mammals, and is responsible for pigmentation as well as the undesirable browning of fruits and vegetables, is a multi-copper enzyme involved in the synthesis of melanin in human. As it is known, melanin provides protection against harmful ultraviolet radiation, which can lead to serious conditions like skin cancers. However, excessive melanin accumulation could result in hyperpigmented spots, creating aesthetic concerns. Tyrosinase inhibitors could potentially lead to the development of novel skin-whitening agents, anti

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Gobis, Katarzyna, Małgorzata Szczesio, Andrzej Olczak, et al. "Differences in the Structure and Antimicrobial Activity of Hydrazones Derived from Methyl 4-Phenylpicolinimidate." Materials 15, no. 9 (2022): 3085. http://dx.doi.org/10.3390/ma15093085.

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Four novel methyl 4-phenylpicolinoimidate derivatives of hydrazone have been synthesized and evaluated for their antimicrobial activity, including tuberculostatic activity. The compounds obtained are condensates of hydrazonamide or hydrazide with 5-nitro-2-furaldehyde or 5-nitro-2-thiophenecarboxaldehyde. The antimicrobial activity of the tested compounds varied. Compound 3b exhibited significant activity against the tested Gram-positive bacteria (7.8–250 µg/mL). The results of structural tests revealed that the compound is the only one obtained in the form of a Z isomer. Tuberculostatic activ

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Tameem, Abdassalam A. A., and Abdussalam S. Mohamed. "UV-Vis Spectroscopic Study on a New Synthesized 4-Hydroxy-N-[(E)-(2-hydroxyphenyl)methylidene]benzohydrazide as Calorimetric Reagent For Mg2+ Ions." Journal of Pure & Applied Sciences 21, no. 1 (2022): 83–86. http://dx.doi.org/10.51984/jopas.v21i1.1702.

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This study is concerned about the study of the chromogenic properties of hydrazone compound, i.e. 4-hydroxy-N-[(E)-(2-hydroxyphenyl)-methylidene]benzo-hydrazide towards magnesium ion recognition. The hydrazone compound was synthesized and characterized by FT-IR and NMR spectroscopy. The complexation ability of the studied ligand towards Mg2+ was investigated using UV-Vis spectroscopy. Experimental parameters that affect the ligand-metal ion complexation such as effect of solvent, standing time, metal concentration and ligand concentration were investigated. Results show that HNHMB is preferent

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Mohammed, Salim, and Fatin zuhair. "Synthesis , Characterization of Some Benzilyl Hydrazone Derived from Benzilic Acid Hydrazide." JOURNAL OF EDUCATION AND SCIENCE 26, no. 5 (2013): 233–39. http://dx.doi.org/10.33899/edusj.2013.163072.

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Chelushkin, Pavel S., Ksenia V. Polyanichko, Maria V. Leko, Marina Yu Dorosh, Thomas Bruckdorfer, and Sergey V. Burov. "Convenient method of peptide hydrazide synthesis using a new hydrazone resin." Tetrahedron Letters 56, no. 4 (2015): 619–22. http://dx.doi.org/10.1016/j.tetlet.2014.12.056.

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Gurkok, Gokce, Nurten Altanlar, and Sibel Suzen. "Investigation of Antimicrobial Activities of Indole-3-Aldehyde Hydrazide/Hydrazone Derivatives." Chemotherapy 55, no. 1 (2009): 15–19. http://dx.doi.org/10.1159/000166999.

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Patil, Sohan, Shalini Pandey, Amit Singh, Mithun Radhakrishna, and Sudipta Basu. "Hydrazide–Hydrazone Small Molecules as AIEgens: Illuminating Mitochondria in Cancer Cells." Chemistry – A European Journal 25, no. 35 (2019): 8229–35. http://dx.doi.org/10.1002/chem.201901074.

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