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Dissertations / Theses on the topic 'Hypothalamic Pituitary Adrenal Axis (HPA)'

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Published: 3 June 2025

Last updated: 31 July 2025

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1

Kalyani, Manu. "Interaction between Prolactin and the Hypothalamic-Pituitary-Adrenal (HPA) axis." Miami University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=miami1397233916.

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2

Heinzmann, Jan-Michael. "Central and peripheral aspects of hypothalamic-pituitary-adrenal (HPA) axis dysfunction." Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-150032.

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3

Bakirtzi, Georgia. "Epigenetic regulation of POMC : implications for the hypothalamic-pituitary-adrenal (HPA) axis." Thesis, University of Sheffield, 2015. http://etheses.whiterose.ac.uk/9455/.

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4

Seale, Josephine Victoria. "Gonadal steroids : modulators of hypothalamo-pituitary-adrenal (HPA) axis activity throughout life." Thesis, University of Bristol, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414189.

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5

Evanson, Nathan K. "Rapid regulation of the hypothalamus-pituitary-adrenal axis by glutamate and glucocorticoids." Cincinnati, Ohio : University of Cincinnati, 2008. http://rave.ohiolink.edu/etdc/view.cgi?acc_num=ucin1227289026.

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Thesis (Ph.D.)--University of Cincinnati, 2008.<br>Advisor: James Herman PhD (Committee Chair), Randall Sakai PhD (Committee Member), Stephen Woods PhD (Committee Member), David D'Alessio MD (Committee Member), Yvonne Ulrich-Lai PhD (Committee Member). Title from electronic thesis title page (viewed Feb. 9, 2009). Keywords: HPA axis; glutamate; cannabinoids; nongenomic; glucocorticoids. Includes abstract. Includes bibliographical references.

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6

Dettmer, Amanda M. "Early rearing experience, hypothalamic-pituitary-adrenal (HPA) activity, and serotonin transporter genotype influences on the development of anxiety in infant rhesus monkeys (Macaca mulatta) /." Amherst, Mass. : University of Massachusetts Amherst, 2009. http://scholarworks.umass.edu/open_access_dissertations/45/.

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7

Janse, van Vuuren Marthinus. "Hypothalamic-pituitary-adrenal-axis vs. the sympatho-adrenal medullary system in the acute response to psychological stress." Thesis, Stellenbosch : University of Stellenbosch, 2011. http://hdl.handle.net/10019.1/6738.

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Thesis (MSc (Physiological Sciences))--University of Stellenbosch, 2011.<br>Includes bibliography.<br>ENGLISH ABSTRACT: The hypothalamic-pituitary-adrenal-(HPA) axis has long been closely associated with psychological stress-induced activation of the adrenal cortex and subsequent glucocorticoid production. Another, less known peripheral limb of the psychological stress response, is the sympatho adrenal medullary pathway. We hypothesized that the sympatho-adrenal medullary system constitutes the primary response to acute psychological stress, with the HPA-axis functioning as a secondary re

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8

Nayar, Shweta. "NOCICEPTIN/ORPHANIN FQ (N/OFQ) REGULATION OF THE STRESS RESPONSE: INTERACTION BETWEEN PROLACTIN AND THE HYPOTHALAMIC-PITUITARY-ADRENAL (HPA) AXIS." Miami University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=miami1382509698.

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9

Finn, David Patrick. "Monoamines and the neuroendocrine response to stress : the role of imidazoline Iâ‚‚ binding sites and Î±â‚‚-adrenoceptors." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340303.

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10

Gordon, Jennifer. "Depression, the dynamic function of the autonomic nervous system and hypothalamic-pituitary-adrenal (HPA) axis, and cardiovascular disease." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110429.

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Depression is associated with an increased risk of cardiovascular disease (CVD). One possible mechanism of this effect is dysregulation of the biological stress systems, the autonomic nervous system (ANS) and hypothalamic-pituitary-adrenal (HPA) axis. The current thesis aimed to better understand the relationship between depression and these two systems. In the first study, the effect of major depression on heart rate recovery following exercise, a marker of ANS tone, was examined in cardiac patients. Depression was associated with poor early heart rate recovery, suggesting reduced post-exerci

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11

Warner, Judith Catherine. "Biology and Environment, Mothers and Infants: Linking Stress Physiology, Depression, Anxiety and Attachment." Thesis, Griffith University, 2013. http://hdl.handle.net/10072/365334.

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The last two decades have seen research on early life experiences expand to include the prenatal environment and, more specifically, examination of the effects of prenatal maternal mental health on foetal and infant development. Cortisol, the hormonal end product of the Hypothalamic Pituitary Adrenal (HPA) Axis, has been identified as one mechanism associated independently with stress, pregnancy and mental health, which can account for changes during foetal development. In the postpartum, these early life experiences may serve as protective or risk factors for the infant. The longitudinal stud

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12

Liu, Keke 1988. "Predicting Posttraumatic Stress Disorder Symptoms During Adolescence: A Longitudinal Study of The Role of Hypothalamic-Pituitary-Adrenal (HPA) Axis Dysfunction." Thesis, University of North Texas, 2016. https://digital.library.unt.edu/ark:/67531/metadc849771/.

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Posttraumatic stress disorder (PTSD) is a trauma-related disorder that may develop in response to traumatic or stressful events. Dysfunction of the Hypothalamic-Pituitary-Adrenal (HPA) axis has been implicated in the disorder. Studies support such dysfunction as being a consequence of PTSD, rather than a precursor. However, most studies of the HPA are either cross-sectional or have been carried out in adults. The aim of the present study was to identify whether HPA dysregulation interacts with stressful experiences to increase the likelihood of developing PTSD symptoms in a community-recruited

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13

Di, Rollo Emma Margaret. "Role of 5α-reductase type 1 in modifying anxiety, appetite and the HPA axis". Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/10026.

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Glucocorticoid excess is associated with adverse effects on a number of physiological parameters, leading to obesity, dysfunction of the hypothalamic-pituitary- adrenal (HPA) axis and behavioural changes such as anxiety and impaired learning and memory. Circulating and local tissue glucocorticoid levels are tightly controlled by the HPA axis but an additional level of control exists in tissues such as brain, liver and adipose tissue. In these structures, enzymes including 5α-reductase 1 (5αR1), catalyse the conversion of corticosterone to A-ring reduced metabolites, which have a different spec

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14

Dembek, Katarzyna Agnieszka. "Renin-Angiotensin-Aldosterone System (RAAS) and Hypothalamic-Pituitary-Adrenal Axis (HPAA) in Critically Ill Foals." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1337797078.

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15

Hurst, Thomas Eugene. "Role of nociceptin/orphanin FQ in the prolactin, hypothalamic-pituitary-adrenal axis, and prolactin receptor response to acute stress in rats." Miami University Honors Theses / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=muhonors1303421079.

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16

Zullig, Kelly. "THE EFFECTS OF ORPHANIN FQ/NOCICEPTIN (OFQ/N) DELETION ON THE HYPOTHALAMIC-PITUITARY-ADRENAL (HPA) AXIS ACTIVITY AND PROLACTIN RESPONSE TO STRESS." Miami University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=miami1218130798.

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17

Catibusic, Sanda-Wictoria. "Subjective Well-Being and Biomarkers of Health : The Relationship between Subjective Well-Being, The immune system and Hypothalamic-Pituitary Adrenal Axis Activation." Thesis, Umeå universitet, Institutionen för psykologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-144135.

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An association between inflammation and mood deterioration has been proposed as a potential explanatory mechanism underlying many pathologies. Previous research attributes this consistently reoccurring connection between inflammation and psychopathology that is often reported within the literature, to a relationship between the HPA axis, the body’s stress response system and the immune system. There is evidence of a bidirectional feedback loop between end-products of the immune system and the HPA-axis such as cytokines and cortisol. This is supported by research reporting that components of su

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18

Berg, Ingrid Helene. "The Relationship Between Insomnia and CFS/ME : The HPA Axis as a Mediator." Thesis, Norges teknisk-naturvitenskapelige universitet, Psykologisk institutt, 2013. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-25191.

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Fatigue is common in the general population, and is the hallmark of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). Although the occurrence of sleep difficulties is known to be common in subjects with fatigue, research on insomnia in such subjects is absent. The current study sought to examine the impact comorbid insomnia has on level of fatigue in subjects with chronic fatigue. The aim of this study is to assess the relationship between insomnia and chronic fatigue, and examine if the relationship is affected by the endocrine activity in the HPA axis. The following hypotheses wer

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19

Solomon, Matia B. "The Effect of Gonadal Hormones on Agonistic Behavior in Previously Defeated Female and Male Syrian Hamsters." Digital Archive @ GSU, 2006. http://digitalarchive.gsu.edu/psych_diss/13.

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Following social defeat, male hamsters exhibit behavioral changes characterized by a breakdown of normal territorial aggression and an increase in submissive/defensive behaviors in the presence of a non-aggressive intruder (NAI). We have termed this phenomenon conditioned defeat (CD). By contrast, only a small subset of defeated females exhibit submissive/defensive behavior in the presence of a NAI. We hypothesized that fluctuations in gonadal hormones might contribute to differences in the display of submissive behavior in intact female hamsters. Following social defeat, proestrous females

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20

Baes, Cristiane von Werne. "Estresse precoce e alterações do eixo hipotálamo-pituitária-adrenal (HPA) na depressão." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/17/17148/tde-30052012-034325/.

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Introdução: Diversos estudos sugerem que o estresse nas fases iniciais de desenvolvimento pode induzir alterações persistentes na capacidade do eixo Hipotálamo-Pituitária-Adrenal (HPA) em responder ao estresse na vida adulta. O desequilíbrio do cortisol tem sido identificado como um correlato biológico dos transtornos depressivos. Essas anormalidades parecem estar relacionadas às mudanças na capacidade dos glicocorticóides circulantes em exercer seu feedback negativo na secreção dos hormônios do eixo HPA por meio da ligação aos receptores mineralocorticóides (RM) e glicocorticóides (RG) nos te

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21

Pereira, Ana Rita Salgueiro. "HPA axis function and episodic memory loss in early Alzheimer disease." Master's thesis, Universidade de Aveiro, 2013. http://hdl.handle.net/10773/12509.

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Mestrado em Bioquímica - Bioquímica Clínica<br>Alzheimer’s disease (AD) is a brain neurodegenerative disease leading to progressive loss of memory and intellectual abilities. It is characterized by the appearance of amyloid-β oligomers (Aβ), which then aggregate into plaques, progressive appearance of neurofibrillary tangles composed of hyperphosphorylated tau, synaptic impairment and neuronal death. The hippocampus, a key structure responsible for memory encoding, is the first brain region affected in AD leading to early episodic memory loss. Aβ accumulation seems to have an important role i

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22

Li-Tempel, Ting [Verfasser], Jobst [Akademischer Betreuer] Meyer, Andrea [Akademischer Betreuer] Schote-Frese, Jobst [Gutachter] Meyer, and Andrea [Gutachter] Schote-Frese. "Hypothalamic-pituitary-adrenal (HPA) axis-related genetic variants influence the stress response / Ting Li-Tempel ; Gutachter: Jobst Meyer, Andrea Schote-Frese ; Jobst Meyer, Andrea Schote-Frese." Trier : Universität Trier, 2020. http://d-nb.info/1210271532/34.

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23

Bertke, Alexander. "Social Buffering By Unfamiliar Adult Males in Periadolescent Guinea Pigs: The Effects on HPA Axis Activity And Fos Induction In The Medial Prefrontal Cortex." Wright State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=wright1559558966039455.

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24

Lamfon, Hawazen Ahmad. "Influence of the hypothalamo-pituitary adrenal (HPA) axis on the inducible form of nitric oxide synthase (NOS-2) in rodent thymus." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408756.

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25

Heinzmann, Jan-Michael [Verfasser], and Rainer [Akademischer Betreuer] Landgraf. "Central and peripheral aspects of hypothalamic-pituitary-adrenal (HPA) axis dysfunction : insights from mice selectively bred for extremes in stress reactivity / Jan-Michael Heinzmann. Betreuer: Rainer Landgraf." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2012. http://d-nb.info/1028191367/34.

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26

Baes, Cristiane von Werne. "A neurobiologia da depressão em pacientes com estresse precose: o papel do eixo HPA e da função dos receptores glicocorticóides (GR) e mineralocorticóides (MR)." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17148/tde-27072016-152342/.

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Introdução: Crescentes evidências indicam que o abandono e o abuso infantis são fatores de risco para transtornos psiquiátricos. Estudos realizados tanto em animais como em humanos sugerem que o estresse nas fases iniciais de desenvolvimento pode induzir alterações persistentes na capacidade do eixo HPA em responder ao estresse na vida adulta e que esse mecanismo pode levar a uma maior suscetibilidade à depressão. Esta desregulação do eixo HPA parece estar relacionada às mudanças na capacidade dos glicocorticóides circulantes em exercer seu feedback negativo na secreção dos hormônios do eixo H

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27

Faure, Jacqueline J. "Repetitive stressors at various lifetime periods differentially affect the HPA axis, neuronal neurotrophic factors and behavioural responses." Thesis, Stellenbosch : University of Stellenbosch, 2006. http://hdl.handle.net/10019.1/1755.

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Thesis (MSc (Physiological Sciences))--University of Stellenbosch, 2006.<br>Early adverse life events appear to increase the susceptibility of developing psychiatric disorders later in life. The molecular mechanisms involved in the development of pathological behaviour remain unclear. Dysregulation of the hypothalamic-pituitary-adrenal axis and alterations in neurotrophic factors have been implicated.

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28

Sautron, Valerie. "Biologie intégrative des réponses de stress et robustesse chez le porc." Thesis, Toulouse, INPT, 2016. http://www.theses.fr/2016INPT0086/document.

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Le travail de cette thèse s’inscrit dans le cadre du projet ANR SUSoSTRESS qui a pour objectif la compréhension des mécanismes moléculaireset génétiques sous-jacents à la variabilité individuelle de réponses de stress et a collecté des données longitudinales à plusieurs niveaux biologiquessur une population d’étude porcine (race Large White). La thèse est organisé en deux partie. La première partie s’articule autour de l’analyse de données cliniques et transcriptomiques collectées à plusieurs pas de temps avant et après application de deux types de stress : injection d’ACTH et de LPS. Dans cet

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29

Maken, Deborah Suzanne. "Central Mechanisms Regulating Pituitary-Adrenal Activity in Infant Guinea Pigs (Cavia porcellus) during Exposure to Psychological Stressors: Independent and Combined Effects of Maternal Separation and Novelty." Wright State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=wright1259610672.

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30

Evuarherhe, Obaro. "Gender, puberty and the hypothalamic-pituitary-adrenal axis." Thesis, University of Bristol, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.618813.

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The hypothalamo-pituitary-adrenal (HPA) axis, a neuroendocrine pathway involved in the stress response is well studied in both human beings and rodents. Major gender-related neuroendocrine changes take place during pubcl1y (days 30 - 60 in rats) including a robust increase in the levels of gonadal steroids which are thought to underlie numerous neural and behavioural changes brought on after puberty. Evidence suggests the HPA axis undergoes significant changes over the pubertal period. This project investigated the effects of gonadal steroids on the HPA axis before and after puberty and the ro

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31

Stirrat, Laura Ingram. "Hypothalamic pituitary adrenal axis dysregulation in obese pregnancy." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/28979.

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There has been a global rise in obesity in the last three decades, and at present one in five women are obese at antenatal booking. Maternal obesity is associated with an increased risk of adverse pregnancy outcomes, including increased fetal size and prolonged pregnancy. In the longer-term, offspring of obese are at increased risk of premature death from a cardiovascular event in their adulthood. One mechanism that has been linked to these outcomes is fetal exposure to glucocorticoids in utero. During normal pregnancy, the maternal hypothalamic pituitary adrenal (HPA) axis undergoes major cha

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32

Näsman, Birgitta. "The limbic-hypothalamic-pituitary-adrenal axis in Alzheimer's disease." Doctoral thesis, Umeå universitet, Geriatrik, 1994. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-140822.

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Dysfunction of the limbic-hypothalamic-pituitary-adrenal (LHPA) axis is a common finding in advanced dementia. In this study, the function of the LHPA axis at different levels was investigated in patients with dementia and in healthy elderly. A subtle disturbance in the feedback regulation of the LHPA axis was found in patients with early (i.e., mild to moderate) Alzheimer’s disease (AD). After 0.5 mg dexamethasone, serum cortisol levels were less suppressed in AD patients and plasma adrenocorticotropin (ACTH) levels were lower as compared with healthy elderly. After stimulation with human cor

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33

Watson, Stuart. "Hypothalamic-pituitary-adrenal axis function in mood disorder patients." Thesis, University of Newcastle upon Tyne, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413260.

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34

Dembek, Katarzyna Agnieszka. "Hypothalamic-pituitary-adrenal axis dysfunction in critically ill foals." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1479220019340433.

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35

Gillich, Anton. "The role of histamine in the hypothalamic - pituitary - adrenal axis /." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=55496.

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Histamine appears to act as a neurotransmitter within the CNS and may be involved in the regulation of a number of physiological systems including the Hypothalamic-Pituitary-Adrenal (HPA) axis. We conducted a series of experiments in rats to examine the role of histamine within the HPA axis. We first determined if histamine undergoes diurnal variations in the paraventricular nucleus, the periventricular nucleus, and the ventro-medial nucleus of the hypothalamus, the frontal cortex, septal nucleus, median eminence, posterior hypothalamus, mammillary bodies, supraoptic nucleus, suprachiasmatic n

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36

Zollner, Ekkehard Werner Arthur. "Hypothalamic-pituitary-adrenal axis suppression in asthmatic children on corticosteroids." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/95468.

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Thesis (PhD)-- Stellenbosch University, 2013.<br>ENGLISH ABSTRACT: Although the effect of inhaled corticosteroids (ICS) on the hypothalamic- pituitary-adrenal axis (HPA) has been regarded as a “benign physiological response”, a survey published in 2002 suggested that adrenal crisis is more common in asthmatic children on ICS than previously thought. Relying on clinical features to detect chronic adrenal insufficiency secondary to corticosteroids may not be wise, as these are non-specific and can therefore easily be missed. Accurate biochemical assessment of the whole axis to detect subcli

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37

Reynolds, Rebecca M. "Programming of the hypothalamic-pituitary-adrenal axis during fetal life." Thesis, University of Edinburgh, 2002. http://hdl.handle.net/1842/23168.

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The aim of this thesis was to study the HPA axis in detail, examining aspects of both activity of the axis and cortisol action, in order to determine variations that could explain the link between low birthweight and subsequent development of cardiovascular risk factors. The principal findings were that men aged 66-77 years, who were of low birthweight and/or with the Metabolic Syndrome, have activation of the HPA axis with increased cortisol response to ACTH<sub>1-24</sub> and increased urinary cortisol metabolite excretion. In contrast to rats programmed by dexamethasone administration durin

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38

Sudlow, Allan William. "Actions of lipocortin-1 on the immune-hypothalamic-pituitary-adrenal axis." Thesis, University of Manchester, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.618752.

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It is thought that the involvement of common mediators such as corticotrophin releasing hormone (CRR), cytokines, prostaglandins (PG's), pituitary peptides and glucocorticoids allows the integration of immune and neuroendocrine activity during the acute phase response (APR) to injury and infection. Glucocorticoids are the major inhibitory component within this complex system, which has been termed the immunehypothalamic- pituitary-adrenal (HPA) axis. In the past, lipocortin-1 (LC-1) has been implicated as a "second messenger" of glucocorticoid actions. The present study explored this potential

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39

Connan, Frances. "An investigation of hypothalamic pituitary adrenal axis hyperactivity in anorexia nervosa." Thesis, King's College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419238.

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40

Hesketh, Shirley Anne. "Pharmacological manipulation of central serotonin and the hypothalamic-pituitary-adrenal axis." Thesis, University of Bristol, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404294.

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41

Buss, Nicholas Alexander Piers Sascha. "The role of formyl peptide receptors within the hypothalamic pituitary adrenal axis." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/5849.

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Annexin 1 (ANXA1) is an important mediator of the regulatory effects of glucocorticoids (GCs) within the neuroendocrine and host defence systems. Recent data suggest that it acts via a formyl peptide receptor (FPR) as a mediator of the negative feedback effects of GCs on adrenocorticotrophic hormone (ACTH) release. In the present study, in vitro and in vivo methods were used to detect and explore further the function of these receptors within the hypothalamo-pituitary-adrenocortical (HPA) axis. Lipopolysaccharide (LPS), given intra-peritoneally (i.p.) or centrally (i.c.v.), increased expressio

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42

Symonds, Catherine. "The hypothalamic-pituitary-adrenal axis in depression : a focus on the hippocampus." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/the-hypothalamic--pituitary--adrenal-axis-in-depression-a-focus-on-the-hippocampus(65f9eca0-f831-4bf0-a934-0f3d21b8856c).html.

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Background: The hypothalamic-pituitary-adrenal (HPA) axis has been implicated in the aetiopathology of depression, and the incidence of HPA dysfunction tends to increase with the severity of treatment resistance. In healthy volunteers (HV), both acute and chronic hypercortisolaemia causes cognitive impairment, including emotional memory. The exact mechanism of this remains unclear; however the action of cortisol on corticosteroid receptors in the hippocampus appears to be crucial and this may also be important in the aetiopathology of depression. The aim of this thesis was to investigate acute

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43

Porter, Richard J. "Corticosteroid serotonin interactions in depression." Thesis, University of Newcastle upon Tyne, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289200.

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44

Beck, Meredith Nell. "Effects of Prolactin on the Hypothalamic Pituitary Adrenal Axis in Postpartum Female Rats." Miami University Honors Theses / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=muhonors1303497697.

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45

Nye, Elisabeth Jane. "Dynamic stimulation tests in the assessment of hypothalamic-pituitary-adrenal axis function in pituitary disease and obesity /." St. Lucia, Qld, 2001. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17166.pdf.

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46

Jeffray, Treena. "The effects of cortisol on the development of the fetal hypothalamic-pituitary-adrenal axis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ41180.pdf.

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47

Tannenbaum, Beth. "Hypothalamic-pituitary-adrenal axis regulation over the lifespan : contribution of dietary and lifestyle factors." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=36842.

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A delicate balance exists between the protective effects of adrenal glucocorticoids (GCs) secreted in response to stress and the negative consequences that the excessive production of these hormones may have for numerous systems. GCs are involved in the regulation of the stress response, have effects on feeding and body weight gain and are associated with the acceleration of central nervous system aging. Their production, secretion, and containment are subject to both environmental modulation and individual variation. Neonatal manipulations known to affect the development of the adult hypothal

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48

Hawkins, Paul. "Nutritional influences on development of the cardiovascular system and the hypothalamic-pituitary-adrenal axis." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325124.

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49

Faghih, Rose Taj. "The FitzHugh-Nagumo model dynamics with an application to the hypothalamic pituitary adrenal axis." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/60161.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2010.<br>Includes bibliographical references (p. 68-70).<br>In this thesis, I revisit the issue of the utility of the FitzHugh-Nagumo (FHN) model for capturing neuron firing behaviors. It has been noted (e.g., see [8]) that the FHN model cannot exhibit certain interesting firing behaviors such as bursting. I will illustrate that, by allowing time-varying parameters for the FHN model, one could overcome such limitations while still retaining the low order complexity of the FHN model. I al

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Cullen, Alexis Elizabeth. "Increased stress susceptibility and hypothalamic-pituitary-adrenal axis dysfunction : early markers of psychosis vulnerability?" Thesis, King's College London (University of London), 2014. http://kclpure.kcl.ac.uk/portal/en/theses/increased-stress-susceptibility-and-hypothalamicpituitaryadrenal-axis-dysfunction(b602f1f0-1006-4491-a112-83d5156f8e13).html.

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Background: Individuals with psychosis are characterised by increased exposure and reactivity to psychosocial stressors and abnormal hypothalamic-pituitary-adrenal (HPA) axis function [i.e., elevated cortisol levels, a blunted cortisol awakening response (CAR), and pituitary volume abnormalities]. The extent to which these features are present among at-risk individuals, prior to illness onset, is currently unclear. Aims: To determine whether putatively at-risk children who present multiple antecedents of schizophrenia (ASz) or a family history of illness (FHx) show increased susceptibility to

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