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Dissertations / Theses on the topic 'I / D polymorphism of the gene ACE'

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Published: 2 June 2025

Last updated: 31 July 2025

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1

Woods, David Richard. "The ACE I/D polymorphism and gene-environment interaction in human performance." Thesis, University of Leeds, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413280.

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2

Silveira, Luciana Carvalho. "O polimorfismo I/D do gene ECA e nefropatia diabética: evidências baseadas em meta-análises." Universidade Federal de Goiás, 2018. http://repositorio.bc.ufg.br/tede/handle/tede/8667.

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Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2018-07-09T11:01:01Z No. of bitstreams: 2 Dissertação - Luciana Carvalho Silveira - 2018.pdf: 1951667 bytes, checksum: 0801db794146b2cd2c97a78cf769e5a6 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2018-07-09T11:23:38Z (GMT) No. of bitstreams: 2 Dissertação - Luciana Carvalho Silveira - 2018.pdf: 1951667 bytes, checksum: 0801db794146b2cd2c97a78cf769e5a6 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>

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3

Umburanas, Rubia Caldas. "O GENE DA ENZIMA CONVERSORA DE ANGIOTENSINA E SUAS VARIANTES GENOTIPICAS EM HIPERTENSOS E NORMOTENSOS." UNIVERSIDADE ESTADUAL DE PONTA GROSSA, 2013. http://tede2.uepg.br/jspui/handle/prefix/931.

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Made available in DSpace on 2017-07-21T19:59:45Z (GMT). No. of bitstreams: 1 Rubia Caldas.pdf: 1293952 bytes, checksum: 52cae77ba14b2beb72e4443c324cd16c (MD5) Previous issue date: 2013-02-28<br>High blood pressure (HBP) is a multifactorial clinical condition characterized by high and sustained levels of blood pressure (BP). The renin-angiotensin system is involved in the control of the BP, and has as a component the angiotensin converting enzyme (ACE). Recent studies that relate gene variants of Angiotensin Converting Enzyme (ACE) gene, increase the risk of hypertension, compared with the pr

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4

Binti, Ahmad Yusof Hazwani. "The Effects of Angiotensin I-Converting Enzyme (ACE) I/D and Alpha-Actinin-3 (ACTN3) R/X Gene Polymorphisms on Human Physical Performance and Health within Malaysian Population." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/14722.

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A disparity population data set in the current literature with limited reports among Asian samples, coupled with the inconsistent findings among different ethnic groups, and lack of information for the involvement of angiotensin I-converting enzyme (ACE) I/D and alpha-actinin-3 (ACTN3) R/X gene polymorphisms in training adaptation have limited the ability of researchers to draw meaningful conclusions pertaining to the effects of these polymorphisms on human physical performance and health. Therefore, this doctoral research implemented three series of studies to examine the effects of ACE I/D a

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5

Chadwick, Ian George. "Studies on the angiotensin converting enzyme gene polymorphism and ACE inhibitors." Thesis, University of Edinburgh, 1997. http://hdl.handle.net/1842/21136.

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Angiotensin converting enzyme (ACE) converts angiotensin I to angiotensin II, an important step in the control of blood pressure. The gene encoding for ACE is subject to an insertion/deletion (I/D) polymorphism which is associated with different levels of the enzyme in serum. This polymorphism accounts for 47% of the variability in serum ACE concentrations between subjects but its relevance to tissue ACE is unknown. ACE inhibition increases kinin level, for example bradykinin. Kinins have been proposed be involved in the pathogenesis of cough due to ACE inhibitors, a common adverse effect in t

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6

Muthumala, A. "The influence of ACE (I/D) polymorphism in cardiovascular disease." Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/1444529/.

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The renin-angiotensin system (RAS) is involved in maintenance of cardiovascular function and has been implicated in coronary heart disease (CHD) and type 2 diabetes (T2D). Pharmacological inhibition of the RAS improves cardiovascular disease outcomes. Angiotensin Converting Enzyme (principal component of RAS) levels are significantly associated with the ACE(I/D) polymorphism. Large studies have demonstrated a mild effect of this polymorphism on CHD risk. However the presence of RAS in diverse tissues implicated in cardiovascular diseases justify the hypothesis that genetic polymorphisms encodi

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7

Neidhardt, Andrea [Verfasser]. "Bedeutung genetischer Polymorphismen in den Genen ACE, CREB1 und TPH1 für Erfolg und Verlauf der Antidepressivatherapie / Andrea Neidhardt." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2009. http://d-nb.info/1023783630/34.

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8

LO, SASSO Bruna. "Polimorfismo I/D del gene ACE: possibile biomarcatore genetico della patologia ipertensiva." Doctoral thesis, Università degli Studi di Palermo, 2014. http://hdl.handle.net/10447/90888.

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9

Myerson, Saul Gareth. "Exercise physiology and the renin-angiotensin system : role of the ACE gene insertion/deletion polymorphism in cardiac growth and endurance exercise." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270592.

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10

HAMAJIMA, NOBUYUKI, HIDEMI GOTO, KAZUO TAJIMA, et al. "NO ASSOCIATION BETWEEN ANGIOTENSIN I CONVERTING ENZYME (ACE) I/D POLYMORPHISM AND GASTRIC CANCER RISK AMONG JAPANESE." Nagoya University School of Medicine, 2011. http://hdl.handle.net/2237/15359.

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11

Kugler, Sibylle [Verfasser], and Cornelius [Akademischer Betreuer] Schüle. "Der Zusammenhang von kardiovaskulären Risikofaktoren einschließlich der Framingham- Risikobewertung und des Nikotinkonsums mit Polymorphismen des ACE-Gens bei depressiven Störungen / Sibylle Kugler ; Betreuer: Cornelius Schüle." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2018. http://d-nb.info/1153338459/34.

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12

Sarzynski, Mark Andrew. "Association of the PAI-1 4G/5G polymorphism with blood pressure in the Quebec Family Study interactions with adiposity, physical activity, and the ACE I/D polymorphism /." Diss., Connect to online resource - MSU authorized users, 2008.

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13

Alves, Cleber Rene. "Reatividade vascular e atividade da ECA em resposta ao treinamento físico são moduladas pelo polimorfismo +9/-9 do gene do receptor B2 de bradicinina." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-03022010-142937/.

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A ausência (9) e não a presença (+9) de um segmento de nove pares de base do gene codificador do receptor B2 de bradicinina (BDKRB2), está associada com a maior transcrição do gene, com fenótipos cardiovasculares e performance física. Entretanto, os efeitos dessas variantes na reatividade vascular são desconhecidos. Hipotetizamos que, 1) a vasodilatação reflexa em resposta ao exercício de handgrip poderia estar aumenta em sujeitos portadores do genótipo -9/-9, 2) O treinamento físico potencializaria essa resposta, e 3) a atividade da enzima conversora de angiotensina-I (ECA) estaria diminuída.

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14

Torkko, Kathleen Carroll. "Vitamin D receptor gene polymorphisms and prostate cancer /." Connect to full text via ProQuest. IP filtered, 2005.

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Thesis (Ph.D. in Epidemiology) -- University of Colorado at Denver and Health Sciences Center, 2005.<br>Typescript. Includes bibliographical references (leaves 95-118). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;

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15

Freund, Christian [Verfasser]. "PROGINS-polymorphism in the human progesterone receptor gene: a potential genetic risk factor for prostate cancer? / Christian Freund." Ulm : Universität Ulm. Medizinische Fakultät, 2002. http://d-nb.info/1015948650/34.

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16

Haubner, André [Verfasser]. "NK cells in patients undergoing allogeneic stem cell transplantation are influenced by the CMV UL40 gene polymorphism / André Haubner." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2019. http://d-nb.info/1189140195/34.

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17

Shiue, Jai-Jün [Verfasser]. "Modifier-Gene in BRCA1/2-Mutationsträgerinnen: SNP-Analyse (single nucleotide polymorphism) in AKAP10, AKAP13 und c-MYC / Jai-Jün Shiue." Köln : Deutsche Zentralbibliothek für Medizin, 2014. http://d-nb.info/1049200160/34.

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18

Grundberg, Elin. "Genetic Variability in Human Bone Phenotypes : The Vitamin D Receptor Gene and the Estrogen Receptor-α Cofactor RIZ Gene". Doctoral thesis, Uppsala University, Department of Medical Sciences, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6784.

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<p>Important candidate genes to human bone phenotypes are those involved in the regulation of hormonal action, such as the vitamin D receptor (VDR) and the estrogen receptor-α (ERα) genes and their cofactors. RIZ1 is a specific ERα cofactor proved to strongly enhance the function of the ERα. </p><p>The main focus of this thesis has been to study genetic variants in the VDR and RIZ genes and their associations to human bone phenotypes using candidate gene and functional approaches. Specifically, polymorphisms in the VDR 3’ untranslated region (UTR) and a deletion/insertion polymorphism of a pro

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19

Bueno, Larissa Souza Mario. "Vitamina D, polimorfismos do gene VDR e neurofibromatose 1." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2012. http://hdl.handle.net/10183/52955.

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Introdução: A Neurofibromatose tipo 1 (NF1) é uma doença genética autossômica dominante causada por mutação no gene NF1 (17q11.2; proteína neurofibromina). A incidência é de aproximadamente 1:3500 recém-nascidos e o diagnóstico clínico é possível na maioria dos casos. Alguns estudos sugeriram que pacientes com NF1 são mais suscetíveis a apresentar deficiência de vitamina D quando comparados à população geral. Objetivo: Determinar os níveis de 25(OH)D em indivíduos com NF1 e em controles saudáveis. Nos pacientes com NF1 nos também avaliamos o fenótipo clínico e analisamos polimorfismos comuns d

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20

Egwuekwe, Ejike Roland. "Vitamin D Receptor Gene Polymorphisms Knowledge And Breast Cancer In Texas." ScholarWorks, 2019. https://scholarworks.waldenu.edu/dissertations/6199.

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Breast cancer is a world health problem and is a leading cause of cancer-related death among women in the United States. However, breast cancer risks were reported to be reduced through exposure to Vitamin D through its Receptors identified as the p53 target gene. The purpose of this study was to assess the associations between VDR gene polymorphisms knowledge/awareness and decisions to reduce breast cancer risks and likelihood of mammogram screening among women in Texas. Data from survey were used. Roy adaptation model was the theoretical framework that guided this quasi- experimental, quanti

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Sultan, Cheryl Sophia [Verfasser], and Markus [Akademischer Betreuer] Hecker. "Functional association of a single nucleotide polymorphism in the human CD40 gene with the pathogenesis of atherosclerosis / Cheryl Sophia Sultan ; Betreuer: Markus Hecker." Heidelberg : Universitätsbibliothek Heidelberg, 2017. http://d-nb.info/1178009718/34.

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22

Albuquerque, Neto Severino Leão de. "Associação dos polimorfismos I/D do gene da ECA e R557X do gene da ACTN3 aos indicadores de desempenho em jovens atletas da natação brasileira." Universidade Católica de Brasília, 2018. https://bdtd.ucb.br:8443/jspui/handle/tede/2442.

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Issa, Chahira Taha Mah D. Ibrahim. "Relação entre perfil cardiometabólico, status de vitamina d e polimorfismo bsmi do gene vdr em idosos." Universidade Federal da Paraíba, 2014. http://tede.biblioteca.ufpb.br:8080/handle/tede/4307.

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Made available in DSpace on 2015-04-17T15:03:04Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 2451134 bytes, checksum: cd1a58c82bfe6936ed40ff974a4a3740 (MD5) Previous issue date: 2014-03-13<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>The high prevalence of hypovitaminosis D in the elderly population is identified as a potential risk factor for the development of cardiovascular diseases. The vitamin D receptor (VDR) is present in various body cells and polymorphisms of the gene encoding it can affect the cell responses to vitamin D. Therefore, this study aimed t

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24

Rissiek, Anne [Verfasser], and Eva [Akademischer Betreuer] Tolosa. "A single nucleotide polymorphism in the ENTPD1 gene determines CD39 expression levels in regulatory T cells and impinges on their function / Anne Rissiek. Betreuer: Eva Tolosa." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2014. http://d-nb.info/1046940260/34.

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25

Tikhonoff, Valerie. "Blood pressure and metabolic phenotypes in relation to SAH gene variants and ADRB1 Arg389Gly and ADRAB2 I/D polymorphisms in white family-based population samples." Doctoral thesis, Università degli studi di Padova, 2008. http://hdl.handle.net/11577/3425992.

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Objectives: Aim of the present doctoral dissertation is independent confirmation in family-based population samples, using strict appropriate statistical approach, of the associations, if any, between blood pressure (BP) and related metabolic phenotypes, analysed as continuous traits, and variations in candidate genes arising from experimental animal models [Spontaneously hypertensive rat-clone A-Hypertension-associated (SAH) gene], and from physiological cascades of the adrenergic system [alfa2B- (ADRAB2) and beta1- (ADRB1) adrenergic receptors]. Methods and Results: The SAH gene variants w

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26

Cobas, Roberta Arnoldi. "Polimorfismo I/D do gene da enzima conversora de angiotensina e C242T do gene do componente p22phox da NADPH oxidase em pacientes com diabetes tipo 1." Universidade do Estado do Rio de Janeiro, 2009. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=1694.

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O sistema renina-angiotensina e o estresse oxidativo têm participação importante na fisiopatologia das complicações crônicas do diabetes. No presente estudo, foram avaliados 103 pacientes com diabetes tipo 1 (DM1) com idade de 28,810,6 anos e duração de doença de 13,18,5 anos e 158 controles não diabéticos quanto à presença dos polimorfismos I/D da ECA e C242T do p22phox, componente essencial para a ativação da NADPH oxidase. Esta análise foi realizada por reação de polimerase em cadeia para ambos os polimorfismos, seguida de restrição enzimática para avaliação do polimorfismo C242T p22phox.

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27

Rezende, Rafael Andrade. "Efeitos de uma sessão de exercício aeróbico nas variáveis hemodinâmicas, neurais e inflamatórias de pacientes com doença renal crônica e sua relação com o polimorfismo da gene da ECA." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-12062018-124609/.

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A doença renal crônica (DRC) se associa com a hiperatividade dos sistemas nervoso simpático e renina-angiotensina-aldosterona, o que leva e aumento da pressão arterial. O exercício aeróbico pode ser utilizado para prevenir as doenças cardiovasculares associadas à DRC, em especial a hipertensão arterial porque uma única sessão de exercício aeróbico promove redução da pressão arterial após a sua execução e esse fenômeno é denominado hipotensão pós-exercício. Este efeito do exercício é mediado pela redução da atividade nervosa simpática periférica e diminuição da atividade do sistema renina-angio

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28

Arejano, Gabrielle Gaspar. "Associações dos polimorfismos genéticos ECA I/D, ACTN3 R577X e PON1 C(-107)T de mulheres diabéticas e/ou hipertensas e controles." Universidade Federal de Pelotas, 2017. http://guaiaca.ufpel.edu.br:8080/handle/prefix/3946.

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Submitted by Aline Batista (alinehb.ufpel@gmail.com) on 2018-05-24T13:05:15Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Dissertacao_Gabrielle_Gastar.pdf: 1814034 bytes, checksum: 214de94beffb5c3d14f679611239db4b (MD5)<br>Approved for entry into archive by Aline Batista (alinehb.ufpel@gmail.com) on 2018-05-24T13:56:54Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Dissertacao_Gabrielle_Gastar.pdf: 1814034 bytes, checksum: 214de94beffb5c3d14f679611239db4b (MD5)<br>Approved for entry into arc

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Ferrarezi, Daniela Andraus de Figueiredo. "Variações alélicas no gene do receptor da vitamina D (VDR) e risco de doença arterial coronariana em pacientes diabéticos tipo 2." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-05052011-142938/.

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A doença cardiovascular (DCV) é a principal causa de mortalidade e morbidade em pacientes portadores de diabetes mellitus tipo 2 (DM 2), estando associada com mais de 80% das mortes nesses pacientes. Portadores de DM 2 têm um risco três vezes maior em relação à indivíduos não diabéticos de desenvolver aterosclerose e suas complicações clínicas como infarto agudo do miocárdio (IAM), acidente vascular cerebral (AVC) e doença vascular periférica. O sistema endócrino da vitamina D regula a diferenciação e a proliferação de vários tipos celulares, além de possuir propriedades antiinflamatórias e an

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Mota, Mariza Aparecida 1956. "Identificação do gene RHD em doadores voluntários de sangue fenotipados como RHD negativo utilizando pools de DNA = RHD allelic identification among D-brazilian blood donors as a routine test using pools of DNA." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310410.

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Orientador: Lilian Maria de Castilho<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-21T01:20:23Z (GMT). No. of bitstreams: 1 Mota_MarizaAparecida_D.pdf: 4935868 bytes, checksum: e4f0e5bb4b8dde3d39725064ffee9de2 (MD5) Previous issue date: 2012<br>Resumo: Alelos RHD que levam à redução da expressão do antígeno D na superfície dos eritrócitos podem levar à tipagem errônea como D- por técnica sorológica e podem causar imunização anti-D quando transfundidos em pacientes. A fim de determinar a ocorrência de tais alelos

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31

Khuseyinova, Natalie [Verfasser]. "Association between plasma levels of the soluble CD14 receptor of lipopolysaccharide and the C(-260)→T polymorphism in the promoter of the CD14 gene and coronary artery disease : investigations in a large case-control study / Natalie Khuseyinova." Ulm : Universität Ulm. Medizinische Fakultät, 2002. http://d-nb.info/1015469833/34.

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Гарбузова, Єлізавета Антонівна, Елизавета Антоновна Гарбузова, Yelizaveta Antonivna Harbuzova, Євген Іванович Дубовик, Евгений Иванович Дубовик та Yevhen Ivanovych Dubovyk. "Частота алельних варіантів гена VEGFA за поліморфізмом C936T у пацієнтів з цукровим діабетом 2-го типу". Thesis, Сумський державний університет, 2017. http://essuir.sumdu.edu.ua/handle/123456789/64479.

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Вступ. Важливе значення вітаміну D у регуляції запальних реакцій і імунної відповіді, а також участь у кістковому ремоделюванні і процесах мінералізації, обумовлюють його вагому роль у патогенезі пародонтиту. Оскільки зниження мінеральної щільності кісткової тканини альвеолярних відростків щелеп є сприятливим фоном для ушкоджуючої дії пародонтопатогенної мікрофлори, останнім часом увагу стоматологів все більше і більше привертає питання зв'язку пародонтиту з порушенням регуляції мінерального обміну. Серед чинників, що активно вивчаються, важливе місце належить генетичним маркерам, а саме полім

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Обухова, Ольга Анатоліївна, Ольга Анатольевна Обухова, Olha Anatoliivna Obukhova та ін. "Зв'язок Aраl поліморфізму гена VDR з ішемічним інсультом з урахуванням дисліпопротеїнемії атерогенного характеру". Thesis, Івано-Франківський національний медичний університет, 2019. https://essuir.sumdu.edu.ua/handle/123456789/80864.

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У розвитку атеросклерозу вагоме значення належить запальним процесам у судинній стінці. Враховуючи імуномоделюючі властивості вітаміну D, його вплив на регуляцію атеросклеротичного процесу може мати важливе значення у розвитку серцево-судинних захворювань, включаючи клапанні кальцифікації, гіпертонію, ішемічний атеротромботичний інсульт.

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Tsai, Chung-Shing, and 蔡忠勳. "Association of CTLA-4 gene and ACE gene polymorphism with oral precancerous lesion in Aborigines of Southern Taiwan." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/16796681707067189575.

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碩士<br>高雄醫學大學<br>牙醫學研究所<br>96<br>Background Oral precancerous lesion (OPL) is a chronic disease that may affect the entire oral cavity. It has been indicated to be associated with inflammatory and immune reaction. Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is a negative regulator of T-lymphocyte activation, it plays an important role in immune tolerance and energy. Angiotensin-converting enzyme (ACE) is expressed in a wide range of tissues. It may be involved in various steps of the inflammatory response. We therefore investigated the role of the CTLA-4 gene and ACE gene polymorphism

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35

Min-Sho and 顧明修. "The Association Study of ACE, CD14, IL-4 Gene Polymorphism and Atopic Disease in Taiwan." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/10447314485197534701.

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碩士<br>中山醫學大學<br>醫學研究所<br>93<br>Atopic disease including allergic rhinitis and asthma, are common in the world and Taiwan. The disease are genally considered to be caused by interaction of genetic and environmental factors. In recent years, studies about genetic factor, including positional cloning, candidate gene studies and polymorphisn of candidate genes are published. But most of the study are reported by other countries. So the aim of our study was to investigate the relationship of candidate genes polymorphism and atopic disease in Taiwan. Angiotensin-converting enzyme (ACE) play a key

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黃雅芳. "ACE gene Insertion/Delection polymorphism associated with metabolic syndrome in Chinese type 2 diabetic patient." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/11298335667282132801.

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碩士<br>國立中興大學<br>生命科學院碩士在職專班<br>90<br>Angiotensin-Converting Enzyme (ACE) Insertion/Deletion (I/D) polymorphism has been shown to be associated with diabetes, hypertension, coronary artery diseases, and diabetic nephropathy, and plasma ACE concentration has been found to be associated with plasma triglyceride and total cholesterol levels in patients with type 2 diabetes。 The goal of this study was to investigate whether ACE gene I/D polymorphism can be associated with metabolic syndrome. 711patients with type 2 diabetes and 750 control subjects were studied. The ACE I/D po

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Huang, Sheng-Hsien, and 黃勝賢. "Association of transporter associated with antigen processing (TAP) gene and angiotensin-I converting enzyme (ACE) gene polymorphism withcalcium oxalate stone disease." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/83180256670886647629.

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碩士<br>中國醫藥大學<br>醫學研究所<br>93<br>Background: Urinary stone disease is a common and multifactorial disease. Inflammation and renal tubular damage might be the causes of stone disease. The function of transporter associated with antigen processing (TAP) is related to immune response and inflammation. It maybe contributed to stone formation. Renin-angiotension system was activated during renal tubular epitheilial injury that may cause by calcium oxalate crystalization. Angiotensin I converting enzyme (ACE) is the key enzyme of renin-angiotensin system (RAS). Single nucleotide polymorphisms provide

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He, Sin-Ru, and 何馨如. "The effect of hepatitis C and ACE gene polymorphism on the development and progression of albuminuria in Type 2 diabetes." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/97328900714187103100.

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碩士<br>高雄醫學大學<br>醫學遺傳學研究所<br>98<br>Background: The prevalence of hepatitis C is 4.4% in Taiwan. The prevalence of hepatitis C in diabetes is significantly higher than non-diabetes. Hepatitis C is also reported to reduce estimated glomerular filtration, and results in chronic kidney disease. ACE (Angiotensin-converting enzyme) I/D polymorphism can affect the activity of ACE, and then results in vascular constriction, inflammation, and renal function impairment. ACE I/D polymorphism was associated with diabetic nephropathy. We explored the influence of hepatitis C and ACE I/D polymorphism on the

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Κοντός, Βασίλειος. "Ο ρόλος του πολυμορφισμού ACE I/D στην εκδήλωση στεφανιαίας νόσου και στην ανταπόκριση των ασθενών σε συγκεκριμένη φαρμακευτική αγωγή". 2006. http://nemertes.lis.upatras.gr/jspui/handle/10889/455.

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Η στεφανιαία νόσος (ΣΝ) αποτελεί τη συχνότερη πάθηση του καρδιαγγειακού συστήματος. Κύρια αιτία της νόσου είναι η αθηροσκλήρυνση, που σήμερα θεωρείται πλέον μια χρόνια φλεγμονώδης αντίδραση του αγγειακού τοιχώματος. Η λειτουργικότητα του ενδοθηλίου του αγγειακού τοιχώματος που αποτελεί προγνωστικό δείκτη καρδιαγγειακών συμβαμάτων και μέθοδο ελέγχου της ανταπόκρισης σε φάρμακα μπορεί να προσδιοριστεί με μέτρηση της αγγειοδιαστολής που διαμεσολαβείται από τη ροή (Flow-Mediated Dilation, FMD) στη βραχιόνιο αρτηρία. Σημαντικό ρόλο στην παθοφυσιολογία της αθηροσκλήρυνσης ασκεί το σύστημα Ρενίνης-Αγ

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Yen, Tzu-Pei, and 顏智培. "Studies on the Relationship between Vitamin D Receptor Gene Apa I Polymorphism and Osteoporosis for Men in Tainan." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/db5u5g.

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碩士<br>嘉南藥理科技大學<br>生物科技系暨研究所<br>100<br>To investigate the relationship between vitamin D receptor gene Apa I polymorphism and osteoporosis for the male is conducted in Tainan regional hospital. The vitamin D receptor genotype was determined by polymerase chain reaction restriction fragment length polymerphisms（PCR-RFLP）for 91 male in Tainan. Bone mineral density（BMD）at lumbar spine and left hip was measured by dual-energy X-ray absorptiometry（DXA）. The allele frequencies of Apa I polymorphism are in line with Hardy- Weinberg equilibrium. Frequencies distribution of VDR Apa I genotype for osteop

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TSAI, YU-JUI, and 蔡育睿. "Association between Vitamin D Receptor Gene Polymorphism and Osteoporosis through Trial Sequential Analysis: Case Control Study and Meta- Analysis." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/cq8848.

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碩士<br>國防醫學院<br>公共衛生學研究所<br>107<br>Introduction The proportion of elderly people aged over 65 in Taiwan has reached 13.9% in the end of 2017. The aging of the population will lead to the increase of chronic diseases such as osteoporosis, which is an important public health issue. Therefore, this study first search the meta- analysis of osteoporosis and gene polymorphism, and used trial sequential analysis to explore whether these SNPs provided by the above article can be affirmed with evidence. Among them, one of SNPs called VDR ApaI still has insufficient evidence, therefore, we first use the

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GIOVINAZZO, SALVATORE. "Vitamin D receptor gene polymorphisms/haplotypes and serum 25(OH)D3 levels in Hashimoto's thyroiditis." Doctoral thesis, 2017. http://hdl.handle.net/11570/3105461.

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Vitamin D deficiency and/or reduced function, as per certain polymorphisms of the vitamin D receptor (VDR) gene, have been related to several autoimmune disorders. The present study was aimed to investigate the association of Hashimoto's thyroiditis with vitamin D status and functional polymorphisms (SNPs) of the VDR gene. In this case-control study, 200 euthyroid subjects were enrolled: 100 newly diagnosed HT patients (87 F, 13 M; mean age ± SD 42 ± 15 year) and 100 healthy individuals, matched for age, sex, BMI, and month of blood sampling. Serum 25(OH)D3 was measured by HPLC. The VDR SNPs B

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Hutter, Stephan [Verfasser]. "Natural variation in Drosophila melanogaster : a survey of genome wide DNA sequence polymorphism and gene expression diversity, and the development of new bioinformatic tools / Stephan Hutter." 2007. http://d-nb.info/986065897/34.

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Jiang, Hong [Verfasser]. "C, T polymorphism of the intercellular adhesion molecule-1 gene (Exon 6, Codon 469) : a risk factor for the coronary heart disease and myocardial infarction / vorgeletg von Hong Jiang." 2001. http://d-nb.info/963783106/34.

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Heller, Samuel. "Aldosteron syntáza u arteriální hypertenze a možný vliv polymorfismu jejího genu na hypertrofii levé komory srdeční." Doctoral thesis, 2013. http://www.nusl.cz/ntk/nusl-326710.

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Part I. The aldosterone synthase gene (CYP11B2) polymorphism T-344C in blood pressure and left ventricular hypertrophy. BACKGROUND: Aldosterone is a key cardovascular hormone, it significantly influences volume, pressure and electrolyte balance. Aldosterone plays an important role in development of left ventricular (LV) hypertrophy and myocardial fibrosis. The aldosterone synthase gene (CYP11B2) is an important candidate gene region in essential hypertension. DESIGN AND METHODS: We assessed the influence of the T-344C polymorphism of aldosterone synthase - the rate-limiting enzyme in aldostero

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