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Journal articles on the topic 'I / D polymorphism of the gene ACE'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Salimi, Saeedeh, Mojgan Mokhtari, Minoo Yaghmaei, Mohammad Jamshidi, and Anoosh Naghavi. "Association of Angiotensin-Converting Enzyme Intron 16 Insertion/Deletion and Angiotensin II Type 1 Receptor A1166C Gene Polymorphisms with Preeclampsia in South East of Iran." Journal of Biomedicine and Biotechnology 2011 (2011): 1–6. http://dx.doi.org/10.1155/2011/941515.

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Some evidence suggests that a variety of genetic factors contributed in pathogenesis of the preeclampsia. The aim of this study was to assess the association between the angiotensin-converting enzyme (ACE) I/D and angiotensin II type1 receptor A1166C polymorphisms with preeclampsia. This study was performed in 125 preeclamptic pregnant women and 132 controls. The I/D Polymorphism of the ACE gene was assessed by polymerase chain reaction and the A1166C Polymorphism of the AT1R gene was determined by restriction fragment length polymorphism. The genotype and allele frequencies of I/D polymorphis

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Cam, F. Sirri, Muzaffer Colakoglu, Cevad Sekuri, Sule Colakoglu, Çagatay Sahan, and Afig Berdeli. "Association Between the ACE I/D) Gene Polymorphism and Physical Performance in a Homogeneous Non-Elite Cohort." Canadian Journal of Applied Physiology 30, no. 1 (2005): 74–86. http://dx.doi.org/10.1139/h05-106.

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Background: I/D polymorphism of the ACE gene may be associated with better endurance performance and a stronger response to exercise training. The aim of this study was to investigate the association between ACE gene polymorphism and athletic performance in a homogeneous cohort. Methods: Eighty-eight male non-elite Caucasian Turkish athletes with similar training backgrounds for at least for 6 months were studied for ACE gene polymorphisms by PCR analysis. Performance on the 60-meter sprint and middle-distance running tests were evaluated. Results: The distributions of the ACE I/D genotypes we

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3

Chu, Fen-Fen, Shi-Kun Yang, and Wen-Li Zeng. "The Influence of ACE Insertion/Deletion Gene Polymorphism on the Risk of IgA Nephropathy: A Debatable Topic." Genetics Research 2021 (November 18, 2021): 1–11. http://dx.doi.org/10.1155/2021/3112123.

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Background. The connection between angiotensin-converting enzyme insertion/deletion (ACE I/D) gene polymorphisms and IgA nephropathy (IgAN) was conflicting. This pooled analysis was performed to explore this issue. Methods. All eligible investigations were identified from various electronic databases, and the pooled analysis was evaluated using Stata software. Results. 27 studies with 2538 IgAN cases and 3592 controls were included. In overall subjects, ACE D allele, DD, and II genotype were associated with IgAN susceptibility (D vs. I: OR = 1.21, 95% CI: 1.10–1.32, P < 0.001 ; DD vs. ID +

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Montes-de-Oca-García, Adrián, Alejandro Perez-Bey, Daniel Velázquez-Díaz, et al. "Influence of ACE Gene I/D Polymorphism on Cardiometabolic Risk, Maximal Fat Oxidation, Cardiorespiratory Fitness, Diet and Physical Activity in Young Adults." International Journal of Environmental Research and Public Health 18, no. 7 (2021): 3443. http://dx.doi.org/10.3390/ijerph18073443.

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There is controversy about the relationship between ACE I/D polymorphism and health. Seventy-four healthy adults (n = 28 women; 22.5 ± 4.2 years) participated in this cross-sectional study aimed at determining the influence of ACE I/D polymorphism, ascertained by polymerase chain reaction, on cardiometabolic risk (i.e., waist circumference, body fat, blood pressure (BP), glucose, triglycerides, and inflammatory markers), maximal fat oxidation (MFO), cardiorespiratory fitness (maximal oxygen uptake), physical activity and diet. Our results showed differences by ACE I/D polymorphism in systolic

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Anisenkova, A., Y. Kovalev, A. Kuchinskii, et al. "Structural features of DNAin women with ischemic heart disease." "Arterial’naya Gipertenziya" ("Arterial Hypertension") 14, no. 1 (2008): 53–58. http://dx.doi.org/10.18705/1607-419x-2008-14-1-53-58.

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Clinical aspects, risk factors, results of selective coronary angiography, features of DNA-polymorphism (I/D polymorphism of gene ACE, isoalleles polymorphism gene APOE, SsTI polymorphism gene АРОСЗ, С677Т polymorphism of gene MTHFR, 4a/4b, G894T and T786C polymorphisms eNOs) in 89 women with a various degree of a coronary obstruction. In patients with sings of coronary artery atherosclerosis, familial history i heart disease was observed in most cases (greater degree on a line of mother). The obtained data show the reliable role of allele T, genotype CT gene MTHFRand gene-gene interaction of

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Turgut, Günfer, Sebahat Turgut, Osman Genç, Ayfer Atalay, and Erol Ömer Atalay. "The Angiotensin Converting Enzyme I/D Polymorphism in Turkish Athletes and Sedentary Controls." Acta Medica (Hradec Kralove, Czech Republic) 47, no. 2 (2004): 133–36. http://dx.doi.org/10.14712/18059694.2018.79.

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The angiotensin converting enzyme (ACE) gene is located on human chromosome 17 expressing three genotypes within the intron 16 of the related gene structure. These genotypes are classified as I and D alleles which are termed as insertion and deletion, respectively. This study was carried out to identify possible relationships between the insertion/ deletion (I/D) polymorphisms and athletic performance in Turkish athletes. To be able to determine these relationships, eighty healthy athletes and eighty healthy sedentary controls were genotyped for the ACE I/D polymorphism at gene level. Accordin

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Ito, H., S. Tsukui, T. Kanda, T. Utsugi, T. Ohno, and M. Kurabayashi. "Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and Polyneuropathy in Type 2 Diabetes without Macroalbuminuria." Journal of International Medical Research 30, no. 5 (2002): 476–82. http://dx.doi.org/10.1177/147323000203000502.

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Angiotensin-converting enzyme (ACE) gene polymorphism is thought to be a potent risk factor for nephropathy and retinopathy in diabetes. We investigated the association between polyneuropathy and gene polymorphisms of both the ACE insertion/deletion (I/D) and angiotensinogen (AGT) M235T genes in 84 type 2 diabetic patients without macroalbuminuria (21 with polyneuropathy and 63 without). ACE genotype distribution did not differ significantly between patients with and without polyneuropathy, but the frequency of the I allele was significantly higher in those with polyneuropathy than in those wi

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8

Ghanie, Ali, Radiyati Umi Partan, Taufik Indrajaya, Zulkhair Ali, Mgs Irsan Saleh, and Rachmat Hidayat. "The Effect of Angiotensin-Converting Enzyme Gene Polymorphisms in the Coronary Slow Flow Phenomenon at South Sumatra, Indonesia Population." Open Access Macedonian Journal of Medical Sciences 8, A (2020): 225–30. http://dx.doi.org/10.3889/oamjms.2020.3802.

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BACKGROUND: The coronary slow flow phenomenon (CSFP) is believed to be affected by endothelial dysfunction ruled by renin, angiotensin, aldosterone, and the angiotensin-converting enzyme (ACE). The gene of ACE has been characterized in humans by a major insertion (I)/deletion (D) polymorphism. Serum ACE levels were associated with I/D polymorphism in the ACE-encoding gene. AIM: This study explored and analyzed the role of ACE gene polymorphism risk factors with the incidence of CSFP in the population of South Sumatra, Indonesia. METHODS: This study was a cross-sectional analytic ob

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Kuswara, Hasna Nurazizah, Donny Nauphar, and Ariestya Indah Permata Sari. "Angiotensin-Converting Enzyme Insertion/Deletion (ACE I/D) Gene Polymorphism as a Risk Factor for Essential Hypertension." GHMJ (Global Health Management Journal) 7, no. 4 (2024): 180–90. https://doi.org/10.35898/ghmj-741044.

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Background: Hypertension is the leading cause of death globally due to its complications, including coronary heart disease and stroke. In 2018, hypertension cases in West Java were the second highest among all populations in Indonesia. Genetics is one of the unmodifiable risk factors for hypertension. Angiotensin-converting enzyme insertion/deletion (ACE I/D) gene polymorphism could affect ACE production in the renin-angiotensin-aldosterone system (RAAS), which is linked to the regulation of blood pressure. Aims: To analyze ACE I/D gene polymorphism as a risk factor for hypertension in Cirebon

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Shaker, Olfat Gamil, Manal Fouad Ismail, Esmat Ashour, Heba Mourad Yousif, Mie Afify, and Weaam Gouda. "ACE gene polymorphism and serum ACE level with Progression of Nephropathy in Type 2 Diabetic Patients." JOURNAL OF ADVANCES IN CHEMISTRY 9, no. 3 (2013): 2023–32. http://dx.doi.org/10.24297/jac.v9i3.1009.

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Background. One of the most common complications of diabetes mellitus (DM) is diabetic nephropathy (DN). Angiotensin- converting enzyme (ACE) gene was the first candidate gene of renin-angiotensin system (RAS) for predisposition to DN.Objective. Investigation whether the ACE insertion/deletion (I/D) polymorphism is associated with Egyptian type 2 diabetic patients (T2DM) with nephropathy. In addition, the study investigated the relationship between variants of ACE I/D gene polymorphism and serum ACE level and the progression of nephropathy in Egyptian T2DM patients.Methods. A total of 85 T2DM

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Jasrotia, Raman, Jyotdeep K. Raina, Minakshee Sharma, Rakesh K. Panjaliya, B. R. Kundal, and Parvinder Kumar. "Relationship of MTHFR and ACE gene Variations with Migraine Susceptibility: A Case-Control Study in the Population of North India (Jammu)." Biosciences Biotechnology Research Asia 15, no. 4 (2018): 851–60. http://dx.doi.org/10.13005/bbra/2694.

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Disturbance in vascular functioning pathways has been related to pathophysiology of migraine. The present study investigated the role of MTHFR C677T and ACE I/D gene polymorphisms in migraine susceptibility within the population of Jammu province of J&K state. A sum of 252 subjects including 102 migraine patients and 150 non-migrainous unrelated healthy controls were enrolled for the present study. PCR-RFLP was performed for determining MTHFR gene variations. For detecting insertion/deletion in ACE gene PCR was performed. In case of MTHFR, ‘T’ allele (variant allele) and TT genotype (varia

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Okuno, S., T. Utsugi, T. Ohno, et al. "Angiotensin-Converting Enzyme Gene Polymorphism as a Potent Risk Factor for Developing Microalbuminuria in Japanese Patients with Type 2 Diabetes Mellitus: A 9-Year Follow-up Study." Journal of International Medical Research 31, no. 4 (2003): 290–98. http://dx.doi.org/10.1177/147323000303100406.

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To clarify the risk factors for developing microalbuminuria in patients with type 2 diabetes mellitus, a longitudinal observational study was performed. Fifty patients with normoalbuminuria were recruited and treated conventionally for 9 years. Polymorphisms of the angiotensin-converting enzyme ( ACE) gene and the angiotensinogen M235T polymorphism were examined. During the study period, 12 of the 50 patients developed microalbuminuria; no patients progressed to macroalbuminuria. Multiple logistic regression analysis was performed using age, duration of diabetes, body mass index, haemoglobin A

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13

Radkov, O. V., M. N. Kalinkin, and V. V. Zavarin. "Association of insertion deletion polymorphism of the ACE gene with factors of circulating rennin-angiotensin-aldosterone system and endothelial function of skin microvassals in preeclampsia." Bulletin of Siberian Medicine 10, no. 4 (2011): 32–36. http://dx.doi.org/10.20538/1682-0363-2011-4-32-36.

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The association of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism with plasma ACE, renin activity and endothelial function of skin microvassals were studied. Preeclamptic patients with the DD genotype of ACE I/D gene polymorphism have lowest plasma renin activity level and endothelium-dependent vasodilatation, D allele carriers have highest plasma ACE activity.

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14

Saab, YB, PR Gard, and ADJ Overall. "The association of hypertension with renin–angiotensin system gene polymorphisms in the Lebanese population." Journal of the Renin-Angiotensin-Aldosterone System 12, no. 4 (2011): 588–94. http://dx.doi.org/10.1177/1470320311408465.

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Aim: The study objective was to examine the association of hypertension in the Lebanese population with three renin–angiotensin system gene polymorphisms (RAS): angiotensin-converting enzyme (ACE), angiotensinogen (AGT) and angiotensin-receptor type 1 (AT1R). Methods: A total of 270 subjects (124 hypertensive vs 146 normotensive) were genotyped for ACE insertion (I)/deletion (D), AGT (M235T), and AT1R (A1166C) gene polymorphisms by polymerase chain reaction and restriction fragment length polymorphism. Results: The studied genes showed no deviation from Hardy–Weinberg equilibrium. No associati

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Fatini, Cinzia, Elena Sticchi, Rossella Marcucci, et al. "ACE Insertion/Deletion, But Not −240A>T Polymorphism, Modulates the Severity in Heart Failure." Journal of Investigative Medicine 56, no. 8 (2008): 1004–10. http://dx.doi.org/10.2310/jim.0b013e31818e8028.

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ObjectiveACE gene is reported to be a candidate gene in heart failure. The insertion/deletion (I/D) polymorphism has been observed to be a predictor of mortality in this disease, but no data are available concerning the role of ACE −240A>T polymorphism. In this study, we investigated the role of ACE I/D and −240A>T polymorphisms in influencing both severity and clinical outcomes in patients with heart failure, according to New York Heart Association (NYHA) class.PatientsWe studied 323 patients with heart failure (258 men/65 women; age, 70.8 ± 11.5 years) followed-up for 11.9 ± 6.6 months

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Topal, Nurdan Papila, Beste Ozben, Veysel Sabri Hancer, et al. "Polymorphisms of the angiotensin-converting enzyme and angiotensinogen gene in patients with atrial fibrillation." Journal of the Renin-Angiotensin-Aldosterone System 12, no. 4 (2011): 549–56. http://dx.doi.org/10.1177/1470320311399605.

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Activation of the renin–angiotensin system (RAS) is associated with atrial fibrillation (AF). The aim of this study was to investigate the relation between AF and polymorphisms in RAS. One hundred and fifty patients with AF, 100 patients with no documented episode of AF and 100 healthy subjects were consecutively recruited into the study. The angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism, and the M235T, A-20C, and G-6A polymorphisms of the angiotensinogen gene were genotyped. Patients with AF had significantly lower frequency of II genotype of ACE I/D and higher fre

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G, Bansal, Chaithanya TM, Alam MA, and Manchi RK. "Effectiveness of antihypertensive agents in stage I/II hypertensive patients with ace (I/D) gene polymorphism." Journal of Medical and Scientific Research 11, no. 1 (2023): 22–25. http://dx.doi.org/10.17727/jmsr.2023/11-5.

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Background: Angiotensin converting enzyme (ACE) is the key enzyme, regulates the blood pressure which is encoded by 21kb gene that consists of 26 exons and is located on chromosome 17, contains a polymorphism in the form of either Insertion (I) or Deletion (D). The aim was to study the effect of antihypertensive drugs in patients of essential hypertension associated with ACE gene polymorphism. Methods: Hypertensive patients were recruited followed by genetic test was done for detecting ACE gene polymorphism, then patients were divided as Group-A & B. Group –A and B patients were treated wi

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Leonova, M. V. "Cough associated with angiotensin-converting enzyme inhibitors: the role of pharmacogenetics." Pharmacogenetics and Pharmacogenomics, no. 2 (March 4, 2025): 13–18. https://doi.org/10.37489/2588-0527-2024-2-13-18.

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Cough is a common side effect of angiotensin-converting enzyme (ACE) inhibitors, requiring the discontinuation of these medications. The frequency of dry cough in patients treated with ace inhibitors was approximately 1.5–11%, according to a previous study of 35%. The exact mechanism underlying cough caused by ACE inhibitors remains unclear, with the bradykinin pathway being the most widely accepted theory. The roles of genetic polymorphisms in enzyme proteins and ACE inhibitors have been actively discussed by the medical community. Thus, the first studies to assess the role of genetic factors

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Kamińska, Justyna, Aneta Leszczyńska, Kamil Bujak, and Bożena Szyguła-Jurkiewicz. "The role of the I/D polymorphism in the angiotensin-converting enzyme gene in selected cardiovascular diseases." Postępy Higieny i Medycyny Doświadczalnej 72 (August 10, 2018): 760–66. http://dx.doi.org/10.5604/01.3001.0012.2427.

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Angiotensin converting enzyme (ACE) plays an essential role in the functioning of two important systems in the human body by catalysing the synthesis of angiotensin II in the renin-angiotensin-aldosterone system and by degrading bradykinin in the kinin-kallikrein involved in the development of many cardiovascular conditions. It has been shown that ACE activity is largely genetically determined. More than nine hundred various polymorphisms, mostly single nucleotide polymorphisms, have been detected in the ACE gene; however, the most researched one is still the insertion/deletion polymorphism lo

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Kumagai, Hiroshi, Takuro Tobina, Noriko Ichinoseki-Sekine, et al. "Role of selected polymorphisms in determining muscle fiber composition in Japanese men and women." Journal of Applied Physiology 124, no. 5 (2018): 1377–84. http://dx.doi.org/10.1152/japplphysiol.00953.2017.

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Genetic polymorphisms and sex differences are suggested to affect muscle fiber composition; however, no study has investigated the effects of genetic polymorphisms on muscle fiber composition with respect to sex differences. Therefore, the present study examined the effects of genetic polymorphisms on muscle fiber composition with respect to sex differences in the Japanese population. The present study included 211 healthy Japanese individuals (102 men and 109 women). Muscle biopsies were obtained from the vastus lateralis to determine the proportion of myosin heavy chain (MHC) isoforms (MHC-I

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Trebunova, Marianna, Eva Slaba, Viera Habalova, and Zuzana Gdovinova. "ACE I/D polymorphism in Alzheimer’s disease." Open Life Sciences 3, no. 1 (2008): 49–54. http://dx.doi.org/10.2478/s11535-007-0051-9.

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AbstractAngiotensin-converting enzyme (ACE) has been reported to show altered activity in patients with neurological diseases. The recent studies found that a 287 bp insertion/deletion (I/D) polymorphism of the ACE gene may be associated with susceptibility to Alzheimer’s disease (AD) but the results have been heterogenous between studies in Europe. In the present study we examined for the first time the association of ACE I/D polymorphism along with APOE genotype in 70 sporadic AD and 126 control subjects in Slovak Caucasians (Central Europe). An increased risk for AD was observed in subjects

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Dušanović Pjević, Marija, Ljiljana Beslac Bumbaširevic, Ljubica Vojvodic, et al. "Analysis of the Association Between Polymorphisms within PAI-1 and ACE genes and Ischemic Stroke Outcome After rt-PA Therapy." Journal of Pharmacy & Pharmaceutical Sciences 22 (April 23, 2019): 142–49. http://dx.doi.org/10.18433/jpps30339.

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Purpose: Treatment of Ischemic stroke (IS) in acute phase is based on the use of thrombolytic rt-PA therapy. We aimed to determine whether different alleles and genotypes of I/D ACE gene and 4G/5G PAI-1 gene polymorphisms may influence outcome of rt-PA therapy in patients with IS and the occurrence of haemorrhagic transformation (HT). Methods: Our study included 94 consecutive patients with IS treated with rt-PA. Modified Rankin Scale (mRS) at 3rd month after IS was used to determine the stroke outcome, with scores 0-1 defining the favourable outcome, and scores 2-6 defining poor outcome. Geno

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Pan, Yan-Hong, Min Wang, Yan-Mei Huang, et al. "ACE Gene I/D Polymorphism and Obesity in 1,574 Patients with Type 2 Diabetes Mellitus." Disease Markers 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/7420540.

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Association between ACE gene I/D polymorphism and the risk of overweight/obesity remains controversial. We investigated the possible relationship between ACE gene I/D polymorphism and obesity in Chinese type 2 diabetes mellitus (T2DM) patients. In this study, obesity was defined as a body mass index (BMI) value ≥ 25 kg/m2and subjects were classified into 4 groups (lean, normal, overweight, and obese). PCR (polymerase chain reaction) was used to detect the ACE gene I/D polymorphism in T2DM patients. Metabolic measurements including blood glucose, lipid profile, and blood pressure were obtained.

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Voronkov, L. G., N. G. Gorovenko, I. D. Mazur та A. V. Lyashenko. "Поліморфізм I/D гена ангіотензинперетворюючого ферменту: морфофункціональні зміни міокарда та прогностичне значення у хворих з хронічною серцевою недостатністю". Likarska sprava, № 8 (30 грудня 2012): 36–42. http://dx.doi.org/10.31640/ls-2012-8-05.

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The article presents data regarding links of I/D angiotensin-converting enzyme (ACE) gene polymorphism and structural changes in the myocardium and predictive value in chronic heart failure (CHF). We did not find association of I/D ACE gene polymorphism and structural changes in the myocardium and predictive value in patients with CHF, receiving treatment inhibitor ACE.

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Dikmen, Miris, Hasan Veysi Günes, Irfan Degirmenci, Gazi Özdemir, and Ayse Basaran. "Are the angiotensin-converting enzime gene and acticity risk factors for stroke?" Arquivos de Neuro-Psiquiatria 64, no. 2a (2006): 212–16. http://dx.doi.org/10.1590/s0004-282x2006000200008.

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Stroke is a multifactorial disease in which genetic factors play an important role. This study was carried out to determine angiotensin-converting enzyme (ACE) gene polymorphism in Turkish acute stroke patients and to establish whether there is an association of angiotensin-converting enzyme gene I/D polymorphism with clinical parameters. In this study 185 patients and 50 controls were recruited. We have investigated the association among the allelic distribution of the insertion/deletion (I/D) polymorphism of the ACE gene identified by polymerase chain reaction. Distribution of ACE gene I/D g

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Abuaisha, Asmaa Mahmoud, Lamia Faisal Abou Marzoq, Eman Saad Fayyad, Mai Sufian Eljbour, and Abeer Kamal Baraka. "Association of Angiotensin Converting Enzyme Gene Insertion/Deletion Polymorphism with Type 2 Diabetic Nephropathy in Gaza Strip-Palestine." Asian Journal of Health Sciences 4, no. 2 (2018): 1–10. http://dx.doi.org/10.15419/ajhs.v4i2.442.

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Introduction: The insertion/deletion (I/D) polymorphism of 287 bp Alu repeat sequence in intron 16 of Angiotensin Converting Enzyme (ACE) gene resulting in three genotypes I/D, D/D and I/I. ACE gene expression is associated with ACE levels in cells and in the plasma. It indicated that the polymorphism may modulate the expression of the ACE gene. The D/D genotype is believed to confer deleterious effect to many pathogenesis, also, it might be a cause-effect for type 2 diabetic nephropathy (T2DN). In this study, we evaluated the frequency of the different genotypes of ACE gene and investigated i

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Lala Akhundova, Lala Akhundova, Gulmira Alibayova Gulmira Alibayova, Nurmammad Mustafayev Nurmammad Mustafayev, Samira Rustamova Samira Rustamova, and Irada Huseynova Irada Huseynova. "IMPACT OF ANGIOTENSIN-1 CONVERTING ENZYME GENE INSERTION/DELETION (I/D) POLYMORPHISM ON DIABETES MELLITUS SUSCEPTIBILITY AMONG AZERBAIJAN POPULATION." Ambiance in Life International Scientific Journal in Medicine of Southern Caucasus 06, no. 01 (2021): 63–68. http://dx.doi.org/10.36962/0601202163.

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The association between the angiotensin‑converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and the risk of diabetes mellitus developing in the Azerbaijan population is not studied yet. Therefore, the aim of the present study was to investigate the association of ACE I/D gene polymorphism and the risk of developing diabetes in Azerbaijan population. A total of 200 individual consisting of 100 control subjects and 100 patients with diabetes mellitus (28 patients I type DM (11 male and 17 female); 72 patients II type DM (21 male and 51 female)) were recruited. DNA was extracted fr

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Zhou, Tian-Biao, Yuan-Han Qin, Chao Ou, et al. "A meta-analysis of the association between angiotensin-converting enzyme insertion/deletion gene polymorphism and steroid-sensitive nephrotic syndrome in children." Journal of the Renin-Angiotensin-Aldosterone System 13, no. 1 (2011): 175–83. http://dx.doi.org/10.1177/1470320311422579.

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Background and objective: Angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism correlates with circulating and cellular ACE concentration. Association between ACE I/D gene polymorphism and steroid-sensitive nephrotic syndrome (SSNS) risk in children is still controversial. This meta-analysis was performed to evaluate the relation between ACE I/D gene polymorphism and SSNS susceptibility in children. Methods: The relevant investigations were screened from the search engines of PubMed, Cochrane Library and CBM-disc (China Biological Medicine Database) as of 1 March 2011

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Obraztsova, G. I., A. S. Glotov, T. V. Stepanova, T. E. Ivashchenko, and Y. R. Kovalev. "Analysis of polymorphisms of renin-angiotensin system and bradykinin receptor genes in children and adolescents with primary arterial hypertension." "Arterial’naya Gipertenziya" ("Arterial Hypertension") 12, no. 2 (2006): 156–60. http://dx.doi.org/10.18705/1607-419x-2006-12-2-156-160.

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We inspected 179 children and adolescents aged 9-17 years with primary arterial hypertension (AH) and 158 schoolchildren aged 7-17 years. All the hypertensive children underwent 24 hour ABPM. Family history of all the children was studied in particular of cardiovascular diseases. The 19-83G/A polymorphism of renin gene (REN), the M235T polymorphism of the angiotensinogen gene (AGT), the I/D polymorphism of angiotensin converting gene (ACE), the Al 166C polymorphism of angiotensin II type 1 receptor (AGTR1) gene, the C3123A polymorphism of angiotensin II type 2 receptor gene (AGTR2), I/D and T/

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El-Sayed Marei, Yara, Ahmed Abdallah Bayoumy, Hassnaa Mohamed Abulazm Nassar, Bassam Mansour, and Asmaa Bakeir Hamady. "The Relation between ACE Gene Polymorphism and the Severity of COVID-19 Infection." International Journal of Microbiology 2023 (January 4, 2023): 1–7. http://dx.doi.org/10.1155/2023/4540287.

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Introduction. The coronavirus disease 2019 (COVID-19) pandemic, which emerged in China at the end of 2019, rapidly spread worldwide. The angiotensin-converting enzyme (ACE) gene contains an insertion/deletion (I/D) polymorphism that leads to a higher serum ACE level which is associated with several diseases and also with a high mortality rate in SARS. Therefore, this study aimed at assessing the association between ACE gene polymorphism and the risk and severity of COVID-19 disease in patients. Methodology. Forty-five SARS-CoV-2 infected patients and another random control group of 45 healthy

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Utami, Sri Lestari, Dorta Simamora, Ira Idawati, and Jimmy Hadi Widjaja. "ACE I/D and A2350G Polymorphisms are Correlated with Body Mass Index, but Not with Body Weight and Essential Hypertension: Study in Javanese Postmenopausal Women." Molecular and Cellular Biomedical Sciences 8, no. 2 (2024): 96. http://dx.doi.org/10.21705/mcbs.v8i2.426.

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Background: Genetics was one of the risk factors for essential hypertension (EH). Research on ACE I/D and A2350G polymorphisms associated with risk factors for hypertension in Indonesia has never been done. Therefore, this study was conducted to analyze the relationship between the genotype and alleles of this gene with EH, body weight, and body mass index (BMI) in Javanese postmenopausal women.Materials and methods: This cross-sectional study involved 69 postmenopausal Javanese women according to several criteria related with hypertension risk factors. The data were obtained from the measurem

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Nadalin, Sergej, Sanja Dević Pavlić, Vjekoslav Peitl, et al. "Association between Insertion-Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene and Treatment Response to Antipsychotic Medications: A Study of Antipsychotic-Naïve First-Episode Psychosis Patients and Nonadherent Chronic Psychosis Patients." International Journal of Molecular Sciences 23, no. 20 (2022): 12180. http://dx.doi.org/10.3390/ijms232012180.

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We investigated whether a functional insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme (ACE) influenced antipsychotic treatment. At baseline, and after 8 weeks of treatment with various antipsychotic medications, we assessed patients’ Positive and Negative Syndrome Scale (PANSS) scores, PANSS factors, and metabolic-syndrome-related parameters (fasting plasma lipid and glucose levels, and body mass index). A total of 186 antipsychotic-naïve first-episode psychosis patients or nonadherent chronic psychosis individuals (99 males and 87 females) were genotyped by polymerase ch

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Nesen, A. O., P. S. Semenovykh, K. O. Savicheva, and V. Y. Galchinska. "ACE gene polymorphism and features of kidney disorders in patients with type 2 diabetes mellitus." Ukrainian Therapeutical Journal, no. 1—2 (June 30, 2022): 39–43. http://dx.doi.org/10.30978/utj2022-1-39.

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Objective — to determine the prevalence of the Alu Ins/Del polymorphism of the angiotensin‑converting enzyme (ACE) gene in patients with type 2 diabetes mellitus (DM 2) with nephropathy and to identify possible associative relationship between the course of the disease and the genetic profile of the examined subjects. Materials and methods. Examinations involved 73 patients with diabetic nephropathy (DN), treated in the hospital of L. T. Mala Therapy National Institute. The control group consisted of 19 healthy individuals. After the initial examination and depending on the polymorphic v

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Krivdić Dupan, Zdravka, Vlatka Periša, Mirjana Suver Stević, et al. "The Impact of Pentraxin 3 Serum Levels and Angiotensin-Converting Enzyme Polymorphism on Pulmonary Infiltrates and Mortality in COVID-19 Patients." Biomedicines 12, no. 7 (2024): 1618. http://dx.doi.org/10.3390/biomedicines12071618.

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Objectives: The aim of this study was to examine the impact of the pentraxin 3 (PTX3) serum level and angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism on the severity of radiographic pulmonary infiltrates and the clinical outcomes of COVID-19. Methods: The severity of COVID-19 pulmonary infiltrates was evaluated within a week of admission by analyzing chest X-rays (CXR) using the modified Brixia (MBrixa) scoring system. The insertion (I)/deletion (D) polymorphism of the ACE gene and the serum levels of PTX3 were determined for all patients included in the study. R

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Abd Elneam, Ahmed I., Mohammed Saleh Al-Dhubaibi, and Ali Ismaiel Ali Abd Alrheam. "Angiotensin-Converting Enzyme (ACE) D Allele as a Risk Factor for Increase Serum Interleukin-6 and Interleukin-8 in Psoriasis Patients." Open Access Macedonian Journal of Medical Sciences 6, no. 5 (2018): 772–76. http://dx.doi.org/10.3889/oamjms.2018.188.

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BACKGROUND: Psoriasis is a chronic, recurrent inflammatory skin disease. It is characterised by autoimmune, environmental factors and complex genetic disorder.AIM: To explore the role of IL-6, IL-8, and ACE I/D polymorphism in the pathogenesis of Psoriasis and investigation of the relationship between ACE polymorphism and occurrence of psoriasis.PATIENTS AND METHODS: In this study, we took 73 psoriasis patients and 47 healthy patients as a control. These two groups subjected to analysis for ACE gene I/D polymorphism by PCR and biochemical methods.RESULTS: The serum levels of ACE, IL-8 and IL-6

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Lee, Noo Ri, In Wook Hwang, Hyung Jun Kim, Yun Dan Kang, Jin Wan Park, and Han Jun Jin. "Genetic Association of Angiotensin-Converting Enzyme (ACE) Gene I/D Polymorphism with Preterm Birth in Korean Women: Case-Control Study and Meta-Analysis." Medicina 55, no. 6 (2019): 264. http://dx.doi.org/10.3390/medicina55060264.

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Background and Objectives: The ACE gene encodes the angiotensin-converting enzyme (ACE), a component of the renin-angiotensin system. Increased ACE activity may cause abnormal regulation of placental circulation and angiogenesis, resulting in adverse pregnancy outcomes. Previous studies have reported that the insertion/deletion (I/D) polymorphism of the ACE gene is associated with the development of preterm birth (PTB). However, results of the association between ACE gene I/D and PTB are inconsistent in various populations. Therefore, we performed a case-control study and a meta-analysis to ev

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Chandra, Vincent Alexander, Yahwardiah Siregar, and Cut Aria Arina. "Correlation of ACE Gene Polymorphism and Hypertension in Stroke Ischemic Patients." Sumatera Medical Journal 3, no. 1 (2020): 41–47. http://dx.doi.org/10.32734/sumej.v3i1.3310.

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Stroke is the third highest cerebrovascular disease in the world with high mortality and disability rate that is mostly dominated by ischemic stroke. Genetic factor that had been reported to have an indirect effect in increasing the incidence of ischemic stroke is ACE gene polymorphism. ACE gene polymorphism is characterized by the insertion marked by letter (I) or deletion marked by letter (D) on intron 16, chromosome 17. ACE gene polymorphism has drawn a lot of attention from scientists and had been reported to have an indirect effect in increasing the ischemic stroke incidence through patho

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Sudayasa, I. Putu, Fera Husdaningsih, and La Ode Alifariki. "Polymorphism of Gene ACE I/D and Family History of Hypertension as the predisposition of Hypertension." MARCH 2023 19, no. 2 (2023): 236–41. http://dx.doi.org/10.47836/mjmhs.19.2.34.

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Introduction: Hypertension is a polygenic disease that caused 45% of deaths. Various genes have been engaged with the pathogenesis of hypertension. One of these genes affects sodium homeostasis in the kidney, including the ACE I/D gene polymorphism. The present study aimed to investigate the relationship of family history of hypertension and ACE I/D gene polymorphism with the incidence of hypertension in coastal communities of Kendari City. Methods: The study was conducted using a case-control study design. The case group was hypertensive patients based on medical diagnostic by doctors, while

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Sudayasa, I. Putu, Fera Husdaningsih, and La Ode Alifariki. "Polymorphism of Gene ACE I/D and Family History of Hypertension as Predisposition of Hypertension." Malaysian Journal of Medicine and Health Sciences 19, no. 3 (2023): 171–77. http://dx.doi.org/10.47836/mjmhs.19.3.22.

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Introduction: Hypertension is a polygenic disease that caused 45% of deaths. Various genes have been engaged with the pathogenesis of hypertension. One of these genes affects sodium homeostasis in the kidney, including the ACE I/D gene polymorphism. The present study aimed to investigate the relationship of family history of hypertension and ACE I/D gene polymorphism with the incidence of hypertension in coastal communities of Kendari City. Methods: The study was conducted using a case-control study design. The case group was hypertensive patients based on medical diagnostic by doctors, while

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Araz, Mustafa, Sükrü Aynacioglu, Sebnem Aktaran, Belgin Alasehirli, and Vahap Okan. "Association Between Polymorphism of the Angiotensin I Converting Enzyme Gene and Hypertension in Turkish Type II Diabetic Patients." Acta Medica (Hradec Kralove, Czech Republic) 44, no. 1 (2001): 29–32. http://dx.doi.org/10.14712/18059694.2019.83.

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It has been suggested that an insertion/deletion (I/D) polymorphism in intron 16 of the angiotensin converting enzyme (ACE) gene may be associated with essential hypertension. The aim of this study was to examine the association between ACE I/D polymorphism with blood pressure level and hypertension status in Turkish type 2 diabetic subjects. Hundred and seven hypertensive (78 female, 29 male) and 132 normotensive type 2 diabetic subjects (73 female, 59 male) and 138 sex and age matched control subjects (87 female, 51 male) without diabetes and hypertension were included into the study. The I/

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Dmitrenko, O. P., N. S. Karpova, M. K. Nurbekov, and O. V. Papysheva. "I/D Polymorphism Gene ACE and Risk of Preeclampsia in Women with Gestational Diabetes Mellitus." Disease Markers 2020 (December 28, 2020): 1–7. http://dx.doi.org/10.1155/2020/8875230.

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Preeclampsia (PE) and gestational diabetes mellitus (GDM) are the most common complications of pregnancy, which result in adverse outcomes for the mother and the fetus. GDM is regarded as a separate independent risk factor for PE development, as evidenced by a higher preeclampsia rate in gestational diabetes mellitus than in the general population. The role the endothelial cell dysfunction plays is considered to be the most reasonable one in the origin of these diseases. The activity of plasma and tissue angiotensin converting enzyme (ACE) is believed to be genetically controlled. The availabl

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Chernyshov, V. A., A. O. Nesen, P. S. Semenovykh, and K. O. Savicheva. "The association of rs4646994 ACE and rs1799983 eNOS gene polymorphisms with metabolic effects of dapagliflozin in patients with diabetic nephropathy and essential hypertension." Ukrainian Therapeutical Journal, no. 4 (December 23, 2023): 5–17. http://dx.doi.org/10.30978/utj2023-4-5.

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Objective — to establish possible associations of rs4646994 ACE and rs1799983 eNOS gene polymorphisms with metabolic effects of dapagliflozin in patients (pts) with diabetic nephropathy (DN) and essential hypertension (EH). Materials and methods. Clinical investigation and examinations involved 171 pts, from them 85 (49.7%) females and 86 (50.3%) males with DN of I—IV stages and EH of II—III stages, aged 31 to 82 years old (an average age was 59.38±1.58 years). They were also genotyped for rs4646994 (I/D) ACE and for rs1799983 (G894T) eNOS gene polymorphisms with the use of polymerase ch

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Malakoutian, Tahereh, Bahareh Madadi, and Ahmad Ebrahimi. "Evaluation of common polymorphisms of eNOS gene and ACE gene in autosomal dominant polycystic kidney disease patients and their association with hypertension and renal failure." Journal of Renal Injury Prevention 10, no. 1 (2019): e04-e04. http://dx.doi.org/10.34172/jrip.2021.04.

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Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is the most hereditary renal disease that leads to end-stage renal disease (ESRD). Objectives: Since there is no available parameter to assess the clinical course of ADPKD and its outcome, yet, the aim of our study was evaluation of the association of common polymorphisms of eNOS and ACE genes with clinical manifestations (kidney failure and hypertension) in ADPKD. Patients and Methods: Seventy-five ADPKD patients and 100 control subjects participated in our study. Around 7.5 cc of whole blood was taken from each participant an

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Almazroea, Abdulhadi H., Sondos Yousef, Salma M. S. Ahmad, Hanin N. AlHiraky, Amal Al-Haidose, and Atiyeh M. Abdallah. "The Impact of ACE Gene Variants on Acute-Phase Reactants in Children with Rheumatic Heart Disease." Diagnostics 13, no. 10 (2023): 1672. http://dx.doi.org/10.3390/diagnostics13101672.

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Rheumatic heart disease (RHD) is the most important sequela of upper respiratory group A Streptococcus (GAS) infection. The role of the common angiotensin-converting enzyme (ACE) insertion/deletion (I/D) variant in the disease and its subtypes remains uncertain. The acute-phase reactants (APRs) C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) form part of the Jones criteria for diagnosing RHD, and genetic factors are known to influence baseline CRP and ESR levels. Therefore, here, we investigated the relationship between the ACE I/D polymorphism and APR levels in RHD. A total

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Pehlivan, Sacide, Hüseyin Onay, Erol Tavmergen, N. Tavmergen Göker, and Özgür Çoğulu. "Angiotensin Converting Enzyme Gene Polymorphisms In Male Infertility." European Journal of Therapeutics 14, no. 2 (2008): 15–17. http://dx.doi.org/10.58600/eurjther.2008-14-2-1330-arch.

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The aim of this study was to investigate the frequency of Angiotensin Converting Enzyme (ACE) polymorphism in patients with oligospermia or azoospermia and to compare the frequency of polymorphism with the control group which included the men who had a child within 5 years. ACE insersion (I) / deletion (D) polymorphism was investigated at 132 men; 71 of them were diagnosed as azoospermia, 31 of them were diagnosed were oligospermia and 30 of them were healthy control. Analysis revealed that azoospermic, oligospermic and controls in terms of polymorphisms, genotype and allele frequencies, the d

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Elfaki, Imadeldin, Rashid Mir, Faisel M. Abu Duhier, et al. "Clinical Implications of MiR128, Angiotensin I Converting Enzyme and Vascular Endothelial Growth Factor Gene Abnormalities and Their Association with T2D." Current Issues in Molecular Biology 43, no. 3 (2021): 1859–75. http://dx.doi.org/10.3390/cimb43030130.

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Type 2 DM (T2D) results from the interaction of the genetic and environmental risk factors. Vascular endothelial growth factor (VEGF), angiotensin I-converting enzyme (ACE), and MicroRNAs (MiRNAs) are involved in important physiological processes. Gene variations in VEGF, ACE and MiRNA genes are associated with diseases. In this study we investigated the associations of the VEGF-2578 C/A (rs699947), VEGF-2549 insertion/deletion (I/D), and ACE I/D rs4646994 and Mir128a (rs11888095) gene variations with T2D using the amplification refractory mutation system PCR (ARMS-PCR) and mutation specific P

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Ansam Abdulameer Yahya, Dheyaa Jabbar, and Nassar Abdalaema Abdalhadi. "Association of Angiotensin Converting Enzyme (insertion\deletion) and Angiotensin II Type 1 Receptor (A1166C) gene polymorphisms with diabetic nephropathy in Iraqi type 2 diabetic patients." Iraqi Journal of Pharmaceutical Sciences( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 33, no. 3 (2024): 17–29. http://dx.doi.org/10.31351/vol33iss3pp17-29.

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Renin-angiotensin-aldosterone system abnormalities are the most prevalent cause of renal hemodynamic abnormalities, and candidate genes in this system are involved in the etiology of diabetic nephropathy (DN). A polymorphism in the angiotensin converting enzyme (ACE) gene I(insertion)\D(deletion) has been correlated to plasma ACE levels. Furthermore, the Angiotensin II Type 1 Receptor AGT1R (A1166C) expression pattern is highly related to nephropathy. The objectives of this study involved evaluating the frequency of the ACE (I/D) and AGT1R (A1166C) gene polymorphisms and investigating the asso

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Faure-Delanef, Laurence, Bruno Baudin, Bénédicte Bénéteau-Burnat, Jean-Christophe Beaudoin, Jacqueline Giboudeau, and Daniel Cohen. "Plasma concentration, kinetic constants, and gene polymorphism of angiotensin I-converting enzyme in centenarians." Clinical Chemistry 44, no. 10 (1998): 2083–87. http://dx.doi.org/10.1093/clinchem/44.10.2083.

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Abstract We have determined serum activity and kinetic constants of angiotensin I-converting enzyme (ACE), parallel to an insertion/deletion (I/D) polymorphism in its gene, in French centenarians and controls 20–70 years of age because this enzyme could have an impact on cardiovascular risk, and thus on longevity. Both the ACE D allele and ACE D/D genotype were more frequent in centenarians in comparison with controls, without sex-related differences nor significant correlation with a cardiovascular pathology. In centenarians, I/D polymorphism was correlated with circulating ACE activity (D/D

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Malysheva, I. E., L. V. Topchieva, and E. L. Tikhonovich. "Study of association of ACE gene I/D polymorphism with the risk of pulmonary sarcoidosis (with the participation of the Republic of Karelia residents)." PULMONOLOGIYA 32, no. 1 (2022): 89–94. http://dx.doi.org/10.18093/0869-0189-2022-32-1-89-94.

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The aim of the study was to analyze the association of I/D polymorphism of angiotensin-converting enzyme (ACE) gene with the risk of pulmonary sarcoidosis in ethnic Russians of the Republic of Karelia. Methods. The study enrolled 242 individuals, including 112 patients of Russian nationality residing in the Republic of Karelia with confirmed pulmonary sarcoidosis and 130 healthy donors as a control group. The distribution of alleles and genotypes of I/D polymorphism of ACE gene (rs4646994) in these groups was investigated. Alleles of this polymorphic marker were identified by the method of PCR

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Moqadami, A., E. M. Agah, and M. Khalaj-Kondori. "Ace gene insertion/deletion polymorphism is associated with glioblastoma in an Iranian population: a case-control study." Siberian journal of oncology 22, no. 2 (2023): 85–92. http://dx.doi.org/10.21294/1814-4861-2023-22-2-85-92.

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Background. The insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene has recently been reported to be associated with the pathogenesis and development of human cancers.This study aimed to assess the potential association between ACE (I/D) polymorphism and glioblastoma in an Iranian population.Material and Methods. This case-control study was conducted on 80 patients with glioblastoma and 80 healthy blood donors as controls. Gap-polymerase chain reaction (Gap-PCR) was used to determine the ACE (I/D) genotypes. PCR products were separated and measured by electrop

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