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Journal articles on the topic 'IL-7 receptor alpha'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Fahlman, C., FW Jacobsen, OP Veiby, IK McNiece, HK Blomhoff, and SE Jacobsen. "Tumor necrosis factor-alpha (TNF-alpha) potently enhances in vitro macrophage production from primitive murine hematopoietic progenitor cells in combination with stem cell factor and interleukin-7: novel stimulatory role of p55 TNF receptors." Blood 84, no. 5 (1994): 1528–33. http://dx.doi.org/10.1182/blood.v84.5.1528.1528.

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Abstract Tumor necrosis factor-alpha (TNF-alpha) is a bifunctional regulator of hematopoiesis, and its cellular responses are mediated by two distinct cell surface receptors. TNF-alpha generally inhibits the growth of primitive murine hematopoietic progenitor cells (Lin-Scal+) in response to multiple cytokine combinations, and the p75 TNF receptor is essential in signaling such inhibition. In the present study we show the reverse phenomenon in that TNF-alpha on the same progenitor cell population in combination with stem cell factor (SCF) and interleukin-7 (IL-7) through the p55 TNF receptor c

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2

Fahlman, C., FW Jacobsen, OP Veiby, IK McNiece, HK Blomhoff, and SE Jacobsen. "Tumor necrosis factor-alpha (TNF-alpha) potently enhances in vitro macrophage production from primitive murine hematopoietic progenitor cells in combination with stem cell factor and interleukin-7: novel stimulatory role of p55 TNF receptors." Blood 84, no. 5 (1994): 1528–33. http://dx.doi.org/10.1182/blood.v84.5.1528.bloodjournal8451528.

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Tumor necrosis factor-alpha (TNF-alpha) is a bifunctional regulator of hematopoiesis, and its cellular responses are mediated by two distinct cell surface receptors. TNF-alpha generally inhibits the growth of primitive murine hematopoietic progenitor cells (Lin-Scal+) in response to multiple cytokine combinations, and the p75 TNF receptor is essential in signaling such inhibition. In the present study we show the reverse phenomenon in that TNF-alpha on the same progenitor cell population in combination with stem cell factor (SCF) and interleukin-7 (IL-7) through the p55 TNF receptor can recrui

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3

SON, Min-Young, Kwang-Min CHOI, Min-Soo JOO та Chan-Il PARK. "Molecular Characterization and Expression Analysis of the Interleukin 7 Receptor Alpha Chain (IL-7Rα) Gene from Red Sea Bream (Pagrus major)". JOURNAL OF FISHRIES AND MARINE SCIENCES EDUCATION 32, № 2 (2020): 560–69. http://dx.doi.org/10.13000/jfmse.2020.4.32.2.560.

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4

Sanyal, Mrinmoy, Kira Y. Dionis, Alireza Baradaran-Heravi, et al. "Lack of IL-7 Receptor Alpha Chain (CD127) Expression In T Cells Is a Hallmark of T-Cell Immunodeficiency In Schimke Immuno-Osseous Dysplasia (SIOD)." Blood 116, no. 21 (2010): 2767. http://dx.doi.org/10.1182/blood.v116.21.2767.2767.

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Abstract Abstract 2767 Schimke immuno-osseous dysplasia (SIOD) is an autosomal recessive, incompletely penetrant, childhood disorder associated with biallelic loss-of-function mutations of SMARCAL1 (swi/snf-related matrix-associated actin-dependent regulator of chromatin, subfamily-a-like-1) gene. The SMARCAL1 gene encodes for the DNA annealing helicase although it is unknown why this impairment results in skeletal dysplasia, renal dysfunction, and T-cell lymphopenia. The representation of T-cell subsets in SIOD patients is further characterized by a high proportion of memory (CD45RA−CD45RO+)

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5

He, Y. W., and T. R. Malek. "Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells." Journal of Experimental Medicine 184, no. 1 (1996): 289–93. http://dx.doi.org/10.1084/jem.184.1.289.

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Mice that lack a functional gamma c subunit of the receptors for interleukin (IL)-2, IL-4, IL-7, IL-9, and IL-15 display profound defects in lymphoid development. The IL-7/IL-7R system represents a critical interaction for conventional T and B cell development. In this report, the role of IL-7R alpha in the development of lymphoid lineages other than conventional T and B cells was examined. We demonstrate that gamma delta + T cells were absent in IL-7R alpha-deficient mice, whereas the development and function of natural killer cells were normal. Thus, IL-7R alpha function is required for the

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6

Kawahara, A., Y. Minami, and T. Taniguchi. "Evidence for a critical role for the cytoplasmic region of the interleukin 2 (IL-2) receptor gamma chain in IL-2, IL-4, and IL-7 signalling." Molecular and Cellular Biology 14, no. 8 (1994): 5433–40. http://dx.doi.org/10.1128/mcb.14.8.5433.

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The high-affinity interleukin 2 receptor (IL-2R) consists of at least three distinct subunits: the IL-2R alpha chain (IL-2R alpha), beta chain (IL-2R beta), and gamma chain (IL-2R gamma). It has been shown that the cytoplasmic region of IL-2R beta, but not of IL-2R alpha, is essential for IL-2 signalling to the cell interior. In the present study, we examined the functional role of the IL-2R gamma cytoplasmic region in the IL-3-dependent mouse hematopoietic cell line BAF-B03, which expresses the endogenous IL-2R alpha and IL-2R gamma, or its subline F7, which additionally expresses human IL-2R

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7

Kawahara, A., Y. Minami, and T. Taniguchi. "Evidence for a critical role for the cytoplasmic region of the interleukin 2 (IL-2) receptor gamma chain in IL-2, IL-4, and IL-7 signalling." Molecular and Cellular Biology 14, no. 8 (1994): 5433–40. http://dx.doi.org/10.1128/mcb.14.8.5433-5440.1994.

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The high-affinity interleukin 2 receptor (IL-2R) consists of at least three distinct subunits: the IL-2R alpha chain (IL-2R alpha), beta chain (IL-2R beta), and gamma chain (IL-2R gamma). It has been shown that the cytoplasmic region of IL-2R beta, but not of IL-2R alpha, is essential for IL-2 signalling to the cell interior. In the present study, we examined the functional role of the IL-2R gamma cytoplasmic region in the IL-3-dependent mouse hematopoietic cell line BAF-B03, which expresses the endogenous IL-2R alpha and IL-2R gamma, or its subline F7, which additionally expresses human IL-2R

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8

Marsh, C. B., S. A. Moore, H. A. Pope, and M. D. Wewers. "IL-1ra suppresses endotoxin-induced IL-1 beta and TNF-alpha release from mononuclear phagocytes." American Journal of Physiology-Lung Cellular and Molecular Physiology 267, no. 1 (1994): L39—L45. http://dx.doi.org/10.1152/ajplung.1994.267.1.l39.

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The proinflammatory effects of lipopolysaccharide (LPS) are modulated in large part through the induction of interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) release by mononuclear phagocytes. However, IL-1's target cell effects can be suppressed by IL-1 receptor agonist (IL-1ra). Because mononuclear phagocytes produce and respond to IL-1 via IL-1 receptors, we hypothesized that IL-1ra may also be able to block receptors on IL-1 producer cells and inhibit secondary IL-1-induced IL-1 production. To test this hypothesis, mononuclear cells and alveolar macrophages were s

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9

Hara, T., M. Ichihara, M. Takagi, and A. Miyajima. "Interleukin-3 (IL-3) poor-responsive inbred mouse strains carry the identical deletion of a branch point in the IL-3 receptor alpha subunit gene." Blood 85, no. 9 (1995): 2331–36. http://dx.doi.org/10.1182/blood.v85.9.2331.bloodjournal8592331.

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Interleukin-3 (IL-3) stimulates colony formation of multiple lineages of hematopoietic cells. Bone marrow cells of A/J mice are nonresponsive to IL-3, and this observation has recently been correlated with aberrant mRNA splicing and impaired expression of the IL-3 receptor alpha subunit (IL-3R alpha), a binding component of the high-affinity receptors. We examined the IL-3R alpha gene in 27 inbred mouse strains and found the identical mutation, a 5-bp deletion at the branch point of intron 7, in 10 of these mouse strains. Bone marrow cells isolated from these 10 mouse strains did not express I

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10

Plum, J., M. De Smedt, G. Leclercq, B. Verhasselt, and B. Vandekerckhove. "Interleukin-7 is a critical growth factor in early human T-cell development." Blood 88, no. 11 (1996): 4239–45. http://dx.doi.org/10.1182/blood.v88.11.4239.bloodjournal88114239.

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Highly purified human CD34+ fetal liver stem cells differentiate to mature T cells when seeded in vitro into isolated fetal thymic lobes of severe combined immunodeficient (SCID) mice followed by fetal thymus organ culture (FTOC). Here, this chimeric human-mouse FTOC was used to address the role of interleukin-7 (IL-7) and of the alpha chain of the IL-7 receptor (IL-7R alpha) in early human T-cell development. We report that addition of either the monoclonal antibody (MoAb) M25, which neutralizes both human and mouse IL-7, or the MoAb M21, which recognizes and blocks exclusively the human high

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11

Dadi, H., S. Ke, and CM Roifman. "Activation of phosphatidylinositol-3 kinase by ligation of the interleukin-7 receptor is dependent on protein tyrosine kinase activity." Blood 84, no. 5 (1994): 1579–86. http://dx.doi.org/10.1182/blood.v84.5.1579.1579.

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Abstract Ligation of the interleukin-7 receptor (IL-7R) results in a rapid phosphorylation of tyrosine residues on multiple substrates. In addition, we have recently shown that the IL-7R mediates activation of phosphatidylinositol-3 (PI-3) kinase. Because PI-3 kinase activity can be immunoprecipitated with antiphosphotyrosine antibodies in most receptor systems studied, it has been examined that either PI-3 kinase or an associated protein become tyrosine-phosphorylated after ligand binding. We studied here the possibility that PI-3 kinase, which is directly linked to mitogenic responses in gro

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12

Dadi, H., S. Ke, and CM Roifman. "Activation of phosphatidylinositol-3 kinase by ligation of the interleukin-7 receptor is dependent on protein tyrosine kinase activity." Blood 84, no. 5 (1994): 1579–86. http://dx.doi.org/10.1182/blood.v84.5.1579.bloodjournal8451579.

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Ligation of the interleukin-7 receptor (IL-7R) results in a rapid phosphorylation of tyrosine residues on multiple substrates. In addition, we have recently shown that the IL-7R mediates activation of phosphatidylinositol-3 (PI-3) kinase. Because PI-3 kinase activity can be immunoprecipitated with antiphosphotyrosine antibodies in most receptor systems studied, it has been examined that either PI-3 kinase or an associated protein become tyrosine-phosphorylated after ligand binding. We studied here the possibility that PI-3 kinase, which is directly linked to mitogenic responses in growth facto

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13

Plum, J., M. De Smedt, G. Leclercq, B. Verhasselt, and B. Vandekerckhove. "Interleukin-7 is a critical growth factor in early human T-cell development." Blood 88, no. 11 (1996): 4239–45. http://dx.doi.org/10.1182/blood.v88.11.4239.4239.

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Abstract Highly purified human CD34+ fetal liver stem cells differentiate to mature T cells when seeded in vitro into isolated fetal thymic lobes of severe combined immunodeficient (SCID) mice followed by fetal thymus organ culture (FTOC). Here, this chimeric human-mouse FTOC was used to address the role of interleukin-7 (IL-7) and of the alpha chain of the IL-7 receptor (IL-7R alpha) in early human T-cell development. We report that addition of either the monoclonal antibody (MoAb) M25, which neutralizes both human and mouse IL-7, or the MoAb M21, which recognizes and blocks exclusively the h

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14

Rane, Lalit, Nalini Vudattu, Kasia Bourcier та ін. "Alternative splicing of interleukin-7 (IL-7) and interleukin-7 receptor alpha (IL-7Rα) in peripheral blood from patients with multiple sclerosis (MS)". Journal of Neuroimmunology 222, № 1-2 (2010): 82–86. http://dx.doi.org/10.1016/j.jneuroim.2010.02.014.

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15

Buza-Vidas, Natalija, Henrik Ahlenius, Corrado M. Cilio, et al. "Critical and Complementary Role of FLT3 and Interleukin 7-Receptor Alpha Signaling in T Lymphocyte Development." Blood 104, no. 11 (2004): 112. http://dx.doi.org/10.1182/blood.v104.11.112.112.

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Abstract We recently demonstrated that signaling through the cytokine tyrosine kinase receptor flt3 and interleukin-7 receptor a (IL-7Ra) is indispensable for fetal and adult B cell commitment and development (Sitnicka et al., J. Exp. Med. 198: 1495, 2003). These receptors are also implicated to be important in regulation of T cell development, but their potential interdependence remains unexplored. We recently showed that flt3 ligand (FL)-deficient mice have reduced levels of early thymic progenitors as well as the common lymphoid progenitor (CLP) (Sitnicka et al., Immunity, 17:463, 2002). In

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16

Adachi, S. "Essential role of IL-7 receptor alpha in the formation of Peyer's patch anlage." International Immunology 10, no. 1 (1998): 1–6. http://dx.doi.org/10.1093/intimm/10.1.1.

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17

An, Lijuan, Xinman Dou, Mingli Wang, Wenjuan Luo, Qiang Ma, and Xiaokang Liu. "Involvement of TNF-alpha and IL-10 in breast cancer and patient survival." Tropical Journal of Pharmaceutical Research 19, no. 10 (2020): 2033–39. http://dx.doi.org/10.4314/tjpr.v19i10.2.

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Purpose: To investigate the involvement of tumor necrosis factor α (TNF-α) and interleukin 10 (IL-10) in the pathogenesis of breast cancer in vivo as well as the activity of ten Chinese herbal compounds in human breast cancer (MCF-7) cell proliferation in vitro.Methods: In the in vivo study, the association of serum TNF-α and IL-10 with breast cancer cell invasiveness and prognosis was determined in female patients (n = 192) with breast cancer, while in the in vitro study, ten herbal Chinese compounds were screened for their effectiveness against MCF-7 cells. The levels of TNF-α, IL-10, estrog

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18

Digel, W., M. Schmid, G. Heil, P. Conrad, S. Gillis, and F. Porzsolt. "Human interleukin-7 induces proliferation of neoplastic cells from chronic lymphocytic leukemia and acute leukemias." Blood 78, no. 3 (1991): 753–59. http://dx.doi.org/10.1182/blood.v78.3.753.753.

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Abstract The biologic effects of interleukin-7 (IL-7) and the expression of specific IL-7 membrane receptors on isolated neoplastic cells from previously untreated patients with chronic lymphocytic leukemia as well as acute leukemias were investigated in vitro. Leukemic cells were incubated for up to 6 days with various concentrations of IL-7 (0.01 to 2,000 U/mL). Neoplastic cells of the T- or B-phenotype from chronic as well as from acute leukemias proliferated in a dose-dependent manner. Cells from acute myeloid leukemias also proliferated in response to IL- 7. An optimal proliferative effec

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19

Digel, W., M. Schmid, G. Heil, P. Conrad, S. Gillis, and F. Porzsolt. "Human interleukin-7 induces proliferation of neoplastic cells from chronic lymphocytic leukemia and acute leukemias." Blood 78, no. 3 (1991): 753–59. http://dx.doi.org/10.1182/blood.v78.3.753.bloodjournal783753.

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The biologic effects of interleukin-7 (IL-7) and the expression of specific IL-7 membrane receptors on isolated neoplastic cells from previously untreated patients with chronic lymphocytic leukemia as well as acute leukemias were investigated in vitro. Leukemic cells were incubated for up to 6 days with various concentrations of IL-7 (0.01 to 2,000 U/mL). Neoplastic cells of the T- or B-phenotype from chronic as well as from acute leukemias proliferated in a dose-dependent manner. Cells from acute myeloid leukemias also proliferated in response to IL- 7. An optimal proliferative effect was ach

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20

Bargou, R. C., M. Y. Mapara, C. Zugck, et al. "Characterization of a novel Hodgkin cell line, HD-MyZ, with myelomonocytic features mimicking Hodgkin's disease in severe combined immunodeficient mice." Journal of Experimental Medicine 177, no. 5 (1993): 1257–68. http://dx.doi.org/10.1084/jem.177.5.1257.

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A novel Hodgkin cell line, designated HD-MyZ, was established from the pleural effusion of a 29-yr-old patient with Hodgkin's disease (HD) of nodular sclerosing type. The majority of cells grow adherently and display typical morphological characteristics of Reed-Sternberg (RS) and Hodgkin (H) cells, i.e., large multi- and mononucleated cells with prominent nucleoli. Immunofluorescence analysis revealed a myelomonocytoid immunophenotype (expression of CD13 and CD68, and lack of lymphoid markers). HD-MyZ cells strongly expressed restin, a recently described intermediate filament-associated prote

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21

Mentz, F., F. Ouaaz, A. Michel, et al. "Maturation of acute T-lymphoblastic leukemia cells after CD2 ligation and subsequent treatment with interleukin-2." Blood 84, no. 4 (1994): 1182–92. http://dx.doi.org/10.1182/blood.v84.4.1182.1182.

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Abstract In this study, we have investigated the ability of various cytokines to induce the maturation of acute lymphoblastic leukemia (T-ALL) cells with early T-cell phenotype. Leukemic blasts from 17 untreated T-ALL patients were assayed for their ability to acquire mature T-cell markers, CD3/T-cell receptor (TCR) in particular, after incubation with one or a combination of recombinant human interleukin-1 (IL-1), IL-2, IL-4, IL-7, and CD2-specific monoclonal antibody (MoAb). IL-7 or IL-2 induced the proliferation of some leukemic cells, whereas sequential cell treatment with CD2-MoAb and the

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22

Mentz, F., F. Ouaaz, A. Michel, et al. "Maturation of acute T-lymphoblastic leukemia cells after CD2 ligation and subsequent treatment with interleukin-2." Blood 84, no. 4 (1994): 1182–92. http://dx.doi.org/10.1182/blood.v84.4.1182.bloodjournal8441182.

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In this study, we have investigated the ability of various cytokines to induce the maturation of acute lymphoblastic leukemia (T-ALL) cells with early T-cell phenotype. Leukemic blasts from 17 untreated T-ALL patients were assayed for their ability to acquire mature T-cell markers, CD3/T-cell receptor (TCR) in particular, after incubation with one or a combination of recombinant human interleukin-1 (IL-1), IL-2, IL-4, IL-7, and CD2-specific monoclonal antibody (MoAb). IL-7 or IL-2 induced the proliferation of some leukemic cells, whereas sequential cell treatment with CD2-MoAb and then IL-2 pr

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23

Shamim, Zaiba, Stephanie Thiant, Sylvie Faucher, et al. "Plasma Levels of Soluble Interleukin-7 Receptor Alpha (sIL-7Ra) and IL-7Ra Polymorphism After Allogeneic Stemcell Transplantation,." Blood 118, no. 21 (2011): 4012. http://dx.doi.org/10.1182/blood.v118.21.4012.4012.

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Abstract Abstract 4012 Background: Interleukin-7 (IL-7) is a cytokine essential for T cell development in the thymus and maintenance of peripheral T cells. IL-7 binds to cellular IL-7 receptors (IL-7Ra-common g chain heterodimer), in competition with a soluble form of the receptor, shed by the cells (sIL-7Ra). We have identified single nucleotide polymorphisms in the exons of the gene encoding IL-7Ra (+510T/C rs1494558, +1237 G/C rs1494555, 2087 C/T rs6897932), and previous results by us and by others indicate that IL-7R SNPs are associated with aGvHD and mortality after SCT. Moreover, the bio

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24

Osborne, Lisa C., Salim Dhanji, Jonathan W. Snow та ін. "Impaired CD8 T cell memory and CD4 T cell primary responses in IL-7Rα mutant mice". Journal of Experimental Medicine 204, № 3 (2007): 619–31. http://dx.doi.org/10.1084/jem.20061871.

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Loss of interleukin (IL)-7 or the IL-7 receptor alpha (IL-7Rα, CD127) results in severe immunodeficiencies in mice and humans. To more precisely identify signals governing IL-7 function in vivo, we have disrupted the IL-7Rα Y449XXM motif in mice by knock-in mutagenesis (IL-7Rα449F). Thymic precursors were reduced in number in IL-7Rα449F mice, but in marked contrast to IL-7Rα−/− knockout mice, thymocytes and peripheral T cells developed normally. Strikingly, Listeria infection revealed that CD4 and CD8 T cells had different requirements for IL-7Rα signals. CD4 T cells failed to mount a primary

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25

Luheshi, G. N., A. Stefferl, A. V. Turnbull, et al. "Febrile response to tissue inflammation involves both peripheral and brain IL-1 and TNF-alpha in the rat." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 272, no. 3 (1997): R862—R868. http://dx.doi.org/10.1152/ajpregu.1997.272.3.r862.

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We investigated the role and interaction between tumor necrosis factor (TNF)-alpha, interleukin (IL)-1, and IL-6 in the development of fever and their involvement in brain and systemic pathways in response to localized tissue inflammation caused by injection of turpentine (TPS) in the rat. Intramuscular injection of 10 microl TPS caused significant increases in body temperature, of up to 2 degrees C, compared with saline-treated animals. Fevers were maximal 7-8 h after injection and were preceded by significant increases in plasma bioactive IL-6. No changes in circulating bioactive IL-1 or TNF

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26

Lundström, Wangko, Christina Hermanrud, Maria Sjöstrand, et al. "Interferon beta treatment of multiple sclerosis increases serum interleukin-7." Multiple Sclerosis Journal 20, no. 13 (2014): 1727–36. http://dx.doi.org/10.1177/1352458514532700.

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Background: Interleukin-7 (IL-7) is a non-redundant cytokine for T-cell development and survival. The IL-7 signaling pathway has been genetically and functionally associated with several autoimmune diseases including multiple sclerosis (MS). Objective: The objective of this paper is to elucidate the effect of the widely used immunomodulatory MS therapy interferon beta (IFNβ) on IL-7 homeostasis. Methods: Swedish MS patients were screened for IL-7 concentration in serum and blood cell counts. IL-7 receptor alpha chain (IL-7Rα) expression was determined by semi-quantitative real-time polymerase

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27

Vicari, A., M. do C. de Moraes, J. M. Gombert, et al. "Interleukin 7 induces preferential expansion of V beta 8.2+CD4-8- and V beta 8.2+CD4+8- murine thymocytes positively selected by class I molecules." Journal of Experimental Medicine 180, no. 2 (1994): 653–61. http://dx.doi.org/10.1084/jem.180.2.653.

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We analyzed the phenotype and V beta-T cell receptor (TCR) repertoire, together with interleukin 7 receptor (IL-7R) expression in unfractionated thymocytes stimulated in vitro with IL-7. This culture system results in a specific proliferation of mature thymocytes belonging to the CD3+CD4-, CD4+8-, and CD4-8+ subsets. IL-7 induced a preferential expansion of V beta 8.2+CD4-8- and V beta 8.2+CD4-8- thymocytes. This phenomenon is not observed in beta 2-microglobulin-deficient mice, showing that a fraction of CD4+8- thymocytes, enriched in V beta 8.2+ cells, is selected by class I molecules in nor

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28

Cluitmans, FH, BH Esendam, JE Landegent, R. Willemze, and JH Falkenburg. "Constitutive in vivo cytokine and hematopoietic growth factor gene expression in the bone marrow and peripheral blood of healthy individuals." Blood 85, no. 8 (1995): 2038–44. http://dx.doi.org/10.1182/blood.v85.8.2038.bloodjournal8582038.

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We investigated hematopoietic growth factor (HGF) and cytokine gene expression in the bone marrow (BM) and peripheral blood (PB) of healthy individuals as a starting point for delineating the physiologic role of cytokines in steady state hematopoiesis. BM biopsy specimens and PB samples from 7 healthy individuals were analyzed by polymerase chain reaction amplification of reverse-transcribed RNA using gene-specific primer sets. Consistent gene expression in the BM of all 7 individuals was detected for macrophage colony-stimulating factor (CSF), stem cell factor, interleukin-6 (IL-6), IL-7, ery

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29

Faucher, Sylvie, Angela M. Crawley, Wendy Decker, et al. "Development of a Quantitative Bead Capture Assay for Soluble IL-7 Receptor Alpha in Human Plasma." PLoS ONE 4, no. 8 (2009): e6690. http://dx.doi.org/10.1371/journal.pone.0006690.

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30

Lanfrancone, L., D. Boraschi, P. Ghiara, et al. "Human peritoneal mesothelial cells produce many cytokines (granulocyte colony-stimulating factor [CSF], granulocyte-monocyte-CSF, macrophage- CSF, interleukin-1 [IL-1], and IL-6) and are activated and stimulated to grow by IL-1." Blood 80, no. 11 (1992): 2835–42. http://dx.doi.org/10.1182/blood.v80.11.2835.2835.

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Abstract To investigate the role of peritoneal mesothelial cells in regulating hematopoiesis, as well as inflammation, healing, and tissue regeneration processes, long-term cultures of peritoneal mesothelial cells from human endocavitarian fluids were established. The purity of the cell population was assessed by morphologic and immunocytochemical criteria. Five peritoneal mesothelial cell cultures were analyzed for cytokine expression. Macrophage colony-stimulating factor (M-CSF), granulocyte-CSF (G-CSF), interleukin-1 alpha (IL-1 alpha), IL-1 beta, and IL-6 transcripts were constantly but va

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31

Lanfrancone, L., D. Boraschi, P. Ghiara, et al. "Human peritoneal mesothelial cells produce many cytokines (granulocyte colony-stimulating factor [CSF], granulocyte-monocyte-CSF, macrophage- CSF, interleukin-1 [IL-1], and IL-6) and are activated and stimulated to grow by IL-1." Blood 80, no. 11 (1992): 2835–42. http://dx.doi.org/10.1182/blood.v80.11.2835.bloodjournal80112835.

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To investigate the role of peritoneal mesothelial cells in regulating hematopoiesis, as well as inflammation, healing, and tissue regeneration processes, long-term cultures of peritoneal mesothelial cells from human endocavitarian fluids were established. The purity of the cell population was assessed by morphologic and immunocytochemical criteria. Five peritoneal mesothelial cell cultures were analyzed for cytokine expression. Macrophage colony-stimulating factor (M-CSF), granulocyte-CSF (G-CSF), interleukin-1 alpha (IL-1 alpha), IL-1 beta, and IL-6 transcripts were constantly but variably de

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32

Jacobsen, SE, OP Veiby, J. Myklebust, C. Okkenhaug, and SD Lyman. "Ability of flt3 ligand to stimulate the in vitro growth of primitive murine hematopoietic progenitors is potently and directly inhibited by transforming growth factor-beta and tumor necrosis factor-alpha." Blood 87, no. 12 (1996): 5016–26. http://dx.doi.org/10.1182/blood.v87.12.5016.bloodjournal87125016.

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The recently cloned flt3 ligand (FL) stimulates the growth of primitive hematopoietic progenitor cells through synergistic interactions with multiple other cytokines. The present study is the first demonstrating cytokines capable of inhibiting FL-stimulated hematopoietic cell growth. Tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta 1 (TGF-beta l) potently inhibited the clonal growth of murine Lin-Sca-l+ bone marrow progenitors stimulated by FL alone or in combination with granulocyte colony-stimulating factor (G-CSF), stem cell factor (SCF), interleukin (IL)-3, IL-6,

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33

Shamim, Zaiba, Lars Peter Ryder, Ib Jarle Christensen, Antoine Toubert, Anne M. Dickinson, and Klaus Müller. "Prognostic Significance of Interleukin-7 Receptor-Alpha Gene Polymorphisms in Allogeneic Stem Cell Transplantation: a Confirmatory Study." Blood 114, no. 22 (2009): 798. http://dx.doi.org/10.1182/blood.v114.22.798.798.

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Abstract Abstract 798 Interleukin-7 (IL-7) belongs to the hematopoietic family of cytokines, being essential for T cell development in the thymus and maintenance of peripheral T cells. IL-7 signals through IL-7R, which consists of the gamma common chain as well as an alpha-chain. The alpha-chain, is also used by the receptor of thymic stromal–derived lymphopoitin (TSLP), a cytokine with complex effects on cytokine profiles, including induction of TNF production by dendritic cells. We have sequenced IL-7Ralpha and identified the existence of 4 single nucleotide polymorphisms (+510C/T, +1237 A/G

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Rambaldi, A., S. Bettoni, S. Tosi, et al. "Establishment and characterization of a new granulocyte-macrophage colony-stimulating factor-dependent and interleukin-3-dependent human acute myeloid leukemia cell line (GF-D8)." Blood 81, no. 5 (1993): 1376–83. http://dx.doi.org/10.1182/blood.v81.5.1376.1376.

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Abstract A novel factor-dependent human myeloid leukemia cell line (GF-D8) was established from the peripheral blood of an 82-year-old man suffering from acute myeloblastic leukemia (AML). By morphology, cytochemical staining, and analysis of surface antigens, GF-D8 cells are myeloblasts of immature progenitor origin. The consensus karyotype is 45, XY, -5, 7q-, inv(7) (q31.2q36), 8q+, +8q+, 11q+, 12p-, -15, -17, + marker. The long-term survival and proliferation of GF-D8 cells is dependent on the presence of either granulocyte-macrophage colony-stimulating factor (GM- CSF) or interleukin-3 (IL

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Rambaldi, A., S. Bettoni, S. Tosi, et al. "Establishment and characterization of a new granulocyte-macrophage colony-stimulating factor-dependent and interleukin-3-dependent human acute myeloid leukemia cell line (GF-D8)." Blood 81, no. 5 (1993): 1376–83. http://dx.doi.org/10.1182/blood.v81.5.1376.bloodjournal8151376.

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A novel factor-dependent human myeloid leukemia cell line (GF-D8) was established from the peripheral blood of an 82-year-old man suffering from acute myeloblastic leukemia (AML). By morphology, cytochemical staining, and analysis of surface antigens, GF-D8 cells are myeloblasts of immature progenitor origin. The consensus karyotype is 45, XY, -5, 7q-, inv(7) (q31.2q36), 8q+, +8q+, 11q+, 12p-, -15, -17, + marker. The long-term survival and proliferation of GF-D8 cells is dependent on the presence of either granulocyte-macrophage colony-stimulating factor (GM- CSF) or interleukin-3 (IL-3). Weak

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Antin, JH, HJ Weinstein, EC Guinan, et al. "Recombinant human interleukin-1 receptor antagonist in the treatment of steroid-resistant graft-versus-host disease." Blood 84, no. 4 (1994): 1342–48. http://dx.doi.org/10.1182/blood.v84.4.1342.1342.

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Abstract Acute graft-versus-host disease (GVHD) that is resistant to therapy is a highly lethal complication of marrow transplantation. Inflammatory cytokines such as interleukin-1 (IL-1) may be critical mediators of this process. If so, specific inhibition of IL-1 activity with recombinant human IL-1 receptor antagonist (IL-1Ra), a naturally occurring competitive inhibitor of IL-1, may ameliorate acute GVHD. We performed an open-label, phase I/II trial to evaluate the safety and efficacy of IL-1Ra in 17 patients with steroid-resistant GVHD. The IL- 1Ra was administered as a 24-hour continuous

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Antin, JH, HJ Weinstein, EC Guinan, et al. "Recombinant human interleukin-1 receptor antagonist in the treatment of steroid-resistant graft-versus-host disease." Blood 84, no. 4 (1994): 1342–48. http://dx.doi.org/10.1182/blood.v84.4.1342.bloodjournal8441342.

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Acute graft-versus-host disease (GVHD) that is resistant to therapy is a highly lethal complication of marrow transplantation. Inflammatory cytokines such as interleukin-1 (IL-1) may be critical mediators of this process. If so, specific inhibition of IL-1 activity with recombinant human IL-1 receptor antagonist (IL-1Ra), a naturally occurring competitive inhibitor of IL-1, may ameliorate acute GVHD. We performed an open-label, phase I/II trial to evaluate the safety and efficacy of IL-1Ra in 17 patients with steroid-resistant GVHD. The IL- 1Ra was administered as a 24-hour continuous infusion

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DeKoter, Rodney P., Brock L. Schweitzer, Darrel Jones, David A. Hildeman, and Kelly J. Huang. "The IL-7 Receptor alpha Promoter Is Activated at Distinct Stages during B Cell Development by the Ets Transcription Factors PU.1 and GABP." Blood 106, no. 11 (2005): 3157. http://dx.doi.org/10.1182/blood.v106.11.3157.3157.

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Abstract The cytokine interleukin-7 (IL-7) is required for B and T lymphocyte development, and for the survival and maintenance of both naive and memory T lymphocytes. The receptor for IL-7 (IL-7R) is heterodimeric, consisting of a common gamma chain (γc) and an alpha subunit (IL-7Rα). The γc is expressed in most hematopoietic cell types, but the IL-7Rα gene is regulated in a cell type and developmental stage-specific manner. We have previously shown that the Ets-family transcription factor PU.1 is required to activate transcription of the IL-7Rα gene during fetal lymphocyte development. Howev

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Golden-Mason, Lucy, James R. Burton, Nicole Castelblanco, et al. "Loss of IL-7 receptor alpha-chain (CD127) expression in acute HCV infection associated with viral persistence." Hepatology 44, no. 5 (2006): 1098–109. http://dx.doi.org/10.1002/hep.21365.

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Hsiao, Feng, Julie Frouard, Andrea Gramatica, et al. "Tissue memory CD4+ T cells expressing IL-7 receptor-alpha (CD127) preferentially support latent HIV-1 infection." PLOS Pathogens 16, no. 4 (2020): e1008450. http://dx.doi.org/10.1371/journal.ppat.1008450.

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Taetle, R., and JM Honeysett. "Gamma-interferon modulates human monocyte/macrophage transferrin receptor expression." Blood 71, no. 6 (1988): 1590–95. http://dx.doi.org/10.1182/blood.v71.6.1590.1590.

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Abstract Although circulating human monocytes do not express transferrin (Tf) receptors, cultured adherent blood cells display high-affinity Tf binding sites. In the present studies, effects of various cytokines and biologically active proteins on human monocyte/macrophage Tf receptors were investigated. After culture, Tf receptor expression by adherent blood cells was time dependent and plateaued by 7 days. The addition of interleukin-1 (IL-1), alpha-interferon (alpha-IFN), granulocyte/macrophage-colony stimulating factor (GM-CSF), or human IgG to macrophages cultured for 4 days did not alter

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Taetle, R., and JM Honeysett. "Gamma-interferon modulates human monocyte/macrophage transferrin receptor expression." Blood 71, no. 6 (1988): 1590–95. http://dx.doi.org/10.1182/blood.v71.6.1590.bloodjournal7161590.

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Although circulating human monocytes do not express transferrin (Tf) receptors, cultured adherent blood cells display high-affinity Tf binding sites. In the present studies, effects of various cytokines and biologically active proteins on human monocyte/macrophage Tf receptors were investigated. After culture, Tf receptor expression by adherent blood cells was time dependent and plateaued by 7 days. The addition of interleukin-1 (IL-1), alpha-interferon (alpha-IFN), granulocyte/macrophage-colony stimulating factor (GM-CSF), or human IgG to macrophages cultured for 4 days did not alter Tf recep

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Skeen, M. J., and H. K. Ziegler. "Intercellular interactions and cytokine responsiveness of peritoneal alpha/beta and gamma/delta T cells from Listeria-infected mice: synergistic effects of interleukin 1 and 7 on gamma/delta T cells." Journal of Experimental Medicine 178, no. 3 (1993): 985–96. http://dx.doi.org/10.1084/jem.178.3.985.

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Peritoneal gamma/delta T cells from Listeria-immune mice show an enhanced potential to expand when restimulated with antigens or mitogens in vitro (see companion paper [Skeen, M. J., and H. K. Ziegler. 1993. J. Exp. Med. 178:971]). When cocultured with peritoneal alpha/beta T cells, the gamma/delta T cell population expanded preferentially even when the in vitro stimulus was specific for the alpha/beta T cell population. Purified gamma/delta T cells did not respond to alpha/beta T cell-specific stimuli. If isolated T cell subsets were recombined in cell mixing experiments, the resulting prolif

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Ortaldo, J. R., A. T. Mason, and J. J. O'Shea. "Receptor-induced death in human natural killer cells: involvement of CD16." Journal of Experimental Medicine 181, no. 1 (1995): 339–44. http://dx.doi.org/10.1084/jem.181.1.339.

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Propriocidal regulation of T cells refers to apoptosis induced by interleukin 2 (IL-2) activation with subsequent antigen receptor stimulation. We examined whether natural killer (NK) cells exhibited cytokine- and ligand-induced death similar to activated T cells. Peripheral NK cells were examined for ligand-induced death using antibodies to surface moieties (CD2, CD3, CD8, CD16, CD56), with and without prior activation of IL-2. Only those NK cells stimulated first with IL-2 and then with CD16 exhibited ligand-induced death; none of the other antibody stimuli induced this phenomenon. Next we e

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Hémar, A., A. Subtil, M. Lieb, E. Morelon, R. Hellio, and A. Dautry-Varsat. "Endocytosis of interleukin 2 receptors in human T lymphocytes: distinct intracellular localization and fate of the receptor alpha, beta, and gamma chains." Journal of Cell Biology 129, no. 1 (1995): 55–64. http://dx.doi.org/10.1083/jcb.129.1.55.

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Members of the cytokine receptor family are composed of several noncovalently linked chains with sequence and structure homologies in their extracellular domain. Receptor subfamily members share at least one component: thus the receptors for interleukin (IL) 2 and IL15 have common beta and gamma chains, while those for IL2, 4, 7, and 9 have a common gamma chain. The intracellular pathway followed by IL2 receptors after ligand binding and endocytosis was analyzed by immunofluorescence and confocal microscopy in a human T lymphocytic cell line. Surprisingly, the alpha, beta, and gamma chains had

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Xun, CQ, JS Thompson, CD Jennings, SA Brown, and MB Widmer. "Effect of total body irradiation, busulfan-cyclophosphamide, or cyclophosphamide conditioning on inflammatory cytokine release and development of acute and chronic graft-versus-host disease in H-2- incompatible transplanted SCID mice." Blood 83, no. 8 (1994): 2360–67. http://dx.doi.org/10.1182/blood.v83.8.2360.2360.

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Abstract In a previous study, we found that total body irradiation (TBI) was essential to induce acute graft-versus-host disease (GVHD) after allogeneic H-2-incompatible splenocyte (SP) transplantation in SCID mice. SCID mice (H-2d) conditioned with cyclophosphamide and transplanted intravenously (IV) with 5 x 10(7) C57BL/6 (H-2b) SP developed chronic GVHD within 3 months posttransplant without any evidence of preceding acute GVHD. In this study, SCID mice were conditioned with 4 Gy TBI or non-TBI regimens, either BuCy2 (busulfan 4 mg/kg/d + cyclophosphamide 100 mg/kg/d for 2 days) or Cy5 (cyc

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47

Xun, CQ, JS Thompson, CD Jennings, SA Brown, and MB Widmer. "Effect of total body irradiation, busulfan-cyclophosphamide, or cyclophosphamide conditioning on inflammatory cytokine release and development of acute and chronic graft-versus-host disease in H-2- incompatible transplanted SCID mice." Blood 83, no. 8 (1994): 2360–67. http://dx.doi.org/10.1182/blood.v83.8.2360.bloodjournal8382360.

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In a previous study, we found that total body irradiation (TBI) was essential to induce acute graft-versus-host disease (GVHD) after allogeneic H-2-incompatible splenocyte (SP) transplantation in SCID mice. SCID mice (H-2d) conditioned with cyclophosphamide and transplanted intravenously (IV) with 5 x 10(7) C57BL/6 (H-2b) SP developed chronic GVHD within 3 months posttransplant without any evidence of preceding acute GVHD. In this study, SCID mice were conditioned with 4 Gy TBI or non-TBI regimens, either BuCy2 (busulfan 4 mg/kg/d + cyclophosphamide 100 mg/kg/d for 2 days) or Cy5 (cyclophospha

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Bendelac, A., R. D. Hunziker, and O. Lantz. "Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1 T cells." Journal of Experimental Medicine 184, no. 4 (1996): 1285–93. http://dx.doi.org/10.1084/jem.184.4.1285.

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Natural Killer (NK)1.1+ (NK1) T cells are a specialized subset of alpha/beta T cells that coexpress surface receptors that are normally associated with the NK cell lineage of the innate immune system. On recognition of the conserved, major histocompatibility complex class I-like CD1 molecule, these cells are able to release explosive bursts of interleukin 4 (IL-4), a cytokine that promotes the T helper type 2 (Th2) effector class of an immune response. A unique feature of their T cell receptor (TCR) repertoire is the expression of an invariant TCR alpha chain, V alpha 14-J alpha 281, and of a

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Sereti, Irini, Richard M. Dunham, John Spritzler, et al. "IL-7 administration drives T cell–cycle entry and expansion in HIV-1 infection." Blood 113, no. 25 (2009): 6304–14. http://dx.doi.org/10.1182/blood-2008-10-186601.

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Abstract Interleukin 7 (IL-7) is a common gamma chain receptor cytokine implicated in thymopoiesis and in peripheral expansion and survival of T lymphocytes. The safety and activity of recombinant human IL-7 (rhIL-7) administration were therefore examined in HIV-infected persons. In this prospective randomized placebo-controlled study, a single subcutaneous dose of rhIL-7 was well tolerated with biologic activity demonstrable at 3 μg/kg and a maximum tolerated dose of 30 μg/kg. Injection site reactions and transient elevations of liver function tests were the most notable side effects. Transie

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Uchida, Kazushige, Kazuichi Okazaki, Andras Debrecceni, et al. "Analysis of Cytokines in the Early Development of Gastric Secondary Lymphoid Follicles in Helicobacter pylori-Infected BALB/c Mice with Neonatal Thymectomy." Infection and Immunity 69, no. 11 (2001): 6749–54. http://dx.doi.org/10.1128/iai.69.11.6749-6754.2001.

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ABSTRACT Immunological interaction between the host and Helicobacter pylori seems to play a critical role in follicular formation in gastric mucosa. We reported H. pylori-induced follicular gastritis model using neonatally thymectomized mice. In this study, we investigated the involvement of various cytokines in this model. BALB/c mice were thymectomized on the third day after birth (nTx). At 6 weeks old, these mice were orally infected with H. pylori. Histological studies showed that follicular formation occurred from 8 weeks after the infection and that most of the infiltrating lymphocytes w

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