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Dissertations / Theses on the topic 'Iliac vein and saphenous vein'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Crook, Martin. "Mechanisms of monocyte adhesion to human saphenous vein." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324233.

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2

Cornelissen, Jacqueline. "Saphenous vein bypass graft occlusion : signalling pathways and apoptosis." Thesis, University of the West of England, Bristol, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.431153.

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3

Rutgers, Peter Hans. "To strip or not to strip the incompetent saphenous vein." [Maastricht : Maastricht : Rijksuniversiteit Limburg] ; University Library, Maastricht University [Host], 1993. http://arno.unimaas.nl/show.cgi?fid=6577.

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4

Harley, Suzanne Linda. "Fibrinogen as an inflammatory mediator at the Saphenous Vein Endothelium." Thesis, Imperial College London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300579.

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5

Li, Jun. "Pre-existing intimal hyperplasia and overexpression of TGF-ß1 in saphenous vein grafts before myocardial revascularization in humans: implications for aortocoronary saphenous vein graft disease." Ulm : Univ. Ulm , Med. Fak, 2001. http://nbn-resolving.de/urn:nbn:de:bsz:289-vts-8610.

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6

Souza, Domingos Sávio Ramos de. "Harvesting of saphenous vein for coronary artery bypass grafting : an improved technique that maintains vein wall integrity and provides a high early patency rate /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2002. http://publications.uu.se/theses/91-554-5232-9/.

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7

George, Sarah Jane. "The basis of smooth muscle proliferation in human saphenous vein in vitro." Thesis, Cardiff University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244434.

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8

Watts, Susan Margaret. "Inhibition of neointima formation using the human saphenous vein organ culture model." Thesis, University of Bristol, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264064.

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9

WADA, KENTARO, TOMOYUKI NODA, KENICHI HATTORI, HIDEKI MAKI, AKIRA KITO, and HIROFUMI OYAMA. "AIR VENT OF VEIN GRAFT IN EXTRACRANIAL-INTRACRANIAL BYPASS SURGERY." Nagoya University School of Medicine, 2012. http://hdl.handle.net/2237/16744.

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10

Souza, Domingos. "Harvesting of Saphenous Vein for Coronary Artery Bypass Grafting : An Improved Technique that Maintains Vein Wall Integrity and Provides a High Early Patency Rate." Doctoral thesis, Uppsala University, Thoracic Surgery, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1655.

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<p>The primary aim of this thesis was to modify saphenous vein (SV) harvesting technique and evaluate its clinical importance. A new "no touch" (NT) technique of SV preparation was developed where the vein is harvested with a pedicle of surrounding tissue, which protects the vein from spasm therefore obviating the need for distension.</p><p>Firstly, a prospective randomised study in 156 patients who underwent coronary artery bypass grafting was done to compare this new "no touch" technique to two others, the conventional (C) and the intermediate (I) techniques. A morphological study of the end

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11

Subramonia, Sriram. "Radiofrequency ablation in the treatment of long saphenous vein incompetence : impact on early outcome." Thesis, University of Newcastle upon Tyne, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.442226.

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12

Mughal, Romana Saher. "In vitro effects of insulin and proinsulin C-peptide on human saphenous vein function." Thesis, University of Leeds, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.539686.

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13

Dreifaldt, Mats. "Conduits in coronary artery bypass grafting surgery : Saphenous vein, radial and internal thoracic arteries." Doctoral thesis, Örebro universitet, Institutionen för hälsovetenskap och medicin, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-33265.

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A novel technique for saphenous vein (SV) graft harvesting, the No-touch technique (NT), has been developed at the Dept. of Cardiovascular surgery, Örebro University hospital. With NT the SV is harvested with a pedicle of surrounding tissue. This avoids graft spasm and eliminates the need for distension. The surrounding tissue acts as a structural support and is a rich source of vaso-dilating agents. A randomized controlled trial (RCT) has shown a significantly higher patency rate for NT SV grafts compared to SV grafts harvested with conventional technique (CT). This thesis evaluates some of t

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14

Sölvenäs, Rebecka. "Patency of no-touch saphenous vein grafts incoronary artery bypass grafting. An angiographicfollow up." Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-82625.

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15

Hashmi, Syed. "Effects of CO2 insufflation during endoscopic vein harvesting on the structural and functional viability of saphenous vein endothelium : the role of calcium mobilisation and nitric oxide production." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/effects-of-co2-insufflation-during-endoscopic-vein-harvesting-on-thestructural-and-functional-viability-of-saphenous-vein-endotheliumthe-role-of-calcium-mobilisation-and-nitric-oxide-production(4c619537-47ac-44dc-913a-9f19d755edce).html.

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Endoscopic vein harvesting (EVH) has been reported to decrease saphenectomy related wound complications, improved patient satisfaction, shorter hospital stay and reduced postoperative pain compared with open conventional vein harvesting (OCVH) technique. Criticism of this technique centres on the risk of injury at the time of vein harvest with its potential detrimental effect on the structural viability and long term graft patency. Our hypothesis was to investigate the effect of surgical manipulation and carbon dioxide (CO2) insufflation used as an aid in visualisation, on endothelial preserva

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16

Rautio, T. (Tero). "Primary saphenous vein insufficiency:prospective studies on diagnostic duplex ultrasonography and treatment with endovenous radiofrequency-resistive heating." Doctoral thesis, University of Oulu, 2002. http://urn.fi/urn:isbn:9514267230.

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Abstract The purpose of the present research was (I-II) to evaluate the effects of clinical, hand-held Doppler (HHD) and duplex ultrasonographic examinations on the planning of operative procedure for primary varicose veins, (III) to assess the feasibility, safety and efficacy of endovenous saphenous vein obliteration with radiofrequency-resistive heating and (IV) to compare endovenous saphenous vein obliteration with conventional stripping operation in terms of short-term recovery and costs. Sixty-two legs (in 49 consecutive patients) and 142 legs (in 111 consecutive patients) with pr

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17

Campagnolo, Paola. "Resisdent progenitor cells in adult human saphenous vein : isolation, characterization and contribution to post-natal vascular regeneration." Thesis, University of Bristol, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500396.

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18

Urquhart, Paula, Susan M. Parkin, and Anna Nicolaou. "Profile of eicosanoids produced by human saphenous vein endothelial cells and the effect of dietary fatty acids." Harcourt, 2009. http://hdl.handle.net/10454/4038.

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no<br>Human saphenous vein endothelial cells (HSVECs) derived from primary cultures of adult human veins constitute an excellent in vitro model for studying human endothelial metabolism. In this study we report the14C-labelled prostanoid profile of HSVECs under resting and stimulated conditions and the effect of the n-3 polyunsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid on them. Results indicate that HSVECs while under resting conditions produce mainly prostaglandin F2 ¿(PGF2 ¿). After stimulation with calcium ionophore A23187, the cells were found to synthesise PGI2, P

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19

Alshanwani, Aliah Rajib M. "Role of microRNA-21 in the regulation of human saphenous vein smooth muscle cell function and vascular remodelling." Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/15329/.

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Cardiovascular diseases including coronary artery disease are the major cause of death worldwide. Saphenous vein (SV) bypass grafting is widely used to revascularise atherosclerotic coronary arteries, although failure rates are problematic. Adverse remodelling and intimal hyperplasia (IH) underlie graft failure primarily driven by aberrant smooth muscle cell (SMC) function. Whilst altered SMC function is pivotal to the adaptation of SV grafts, in the longer term excessive cell proliferation and migration lead to intimal hyperplasia that compromises patency rates. Whilst there are no pharmacolo

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20

Paul, Timir, Samit Bhatheja, Hemang Panchal, et al. "Outcomes of Saphenous Vein Graft Intervention With and Without Embolic Protection Device: A Comprehensive Review and Meta-Analysis." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/2771.

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Background: Current guidelines give a class I recommendation to use of embolic protection devices (EPD) for saphenous vein graft (SVG) intervention; however, studies have shown conflicting results. The objective of this meta-analysis is to compare all-cause mortality, major adverse cardiovascular events, myocardial infarction (MI), or target vessel revascularization in SVG intervention with and without EPD. Methods and Results: Literature was searched through October 2016. Eight studies (n=52 893) comparing SVG intervention performed with EPD (n=11 506) and without EPD (n=41 387) were included

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21

Ohnaka, Motoaki. "Effect of microRNA-145 to prevent vein graft disease in rabbits by regulation of smooth muscle cell phenotype." Kyoto University, 2014. http://hdl.handle.net/2433/192144.

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The final publication is available at http://dx.doi.org/10.1016/j.jtcvs.2013.11.054. Motoaki Ohnaka, Akira Marui, Kenichi Yamahara, Kenji Minakata, Kazuhiro Yamazaki, Motoyuki Kumagai, Hidetoshi Masumoto, Shiro Tanaka, Tadashi Ikeda, Ryuzo Sakata, Effect of microRNA-145 to prevent vein graft disease in rabbits by regulation of smooth muscle cell phenotype, The Journal of Thoracic and Cardiovascular Surgery, Volume 148, Issue 2, August 2014, Pages 676-682.e2, ISSN 0022-5223.<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(医学)<br>甲第18544号<br>医博第3937号<br>新制||医||1006(附属図書館)<br>31444<br>京都大学大学院

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22

PRANDI, FRANCESCA. "Identification of early pathophysiological events underlying venous coronary bypass stenosis by a mechano-biology approach." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2014. http://hdl.handle.net/10281/50493.

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Saphenous vein graft disease represents an unresolved problem in coronary artery bypass grafting. After surgery, progressive modification in the vein wall occurs, leading to occlusion of the graft lumen. This process, called intima hyperplasia, involves the participation of vein-resident cells as well as the recruitment of vein-extrinsic cells. Arterial wall strain has recently emerged as one of the factor that can contribute to the pathogenesis of the vein graft disease. Therefore, in collaboration with Department of Bioengineering, Politecnico di Milano we developed a culture system for the

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23

Olufeso, Femi. "The study of the replication of cytomegalovirus in vascular smooth muscle cells and in an organ culture of saphenous vein : potential role in atherogenesis." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249523.

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24

Hemmings, K. E., Kirsten Riches-Suman, M. A. Bailey, D. J. O'Regan, N. A. Turner, and K. E. Porter. "Role of microRNA-145 in DNA damage signalling and senescence in vascular smooth muscle cells of Type 2 diabetic patients." MDPI, 2021. http://hdl.handle.net/10454/18477.

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Yes<br>Increased cardiovascular morbidity and mortality in individuals with type 2 diabetes (T2DM) is a significant clinical problem. Despite advancements in achieving good glycaemic control, this patient population remains susceptible to macrovascular complications. We previously discovered that vascular smooth muscle cells (SMC) cultured from T2DM patients exhibit persistent phenotypic aberrancies distinct from those of individuals without a diagnosis of T2DM. Notably, persistently elevated expression levels of microRNA-145 co-exist with characteristics consistent with aging, DNA damage an

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25

Samano, Ninos. "No-Touch Saphenous Veins in Coronary Artery Bypass Grafting : Long-term Angiographic, Surgical, and Clinical Aspects." Doctoral thesis, Örebro universitet, Institutionen för hälsovetenskaper, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-50039.

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Ischemic heart disease is currently the leading cause of death globally. Coronary artery bypass grafting (CABG) is considered the best treatment for many patients and its success depends on the long-term patency of the conduits. Greater use of arterial grafts has been advocated because of their higher long-term patency compared to saphenous vein grafts (SVGs). Despite this, SVGs account for up to 80% of all grafts used in CABG. Consequently, the long-term patency of the saphenous vein (SV) is one of the most crucial challenges in cardiovascular surgery. The no-touch (NT) SV in CABG has shown a

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26

Meerits, Jonna. "Blodtrycksmanschett eller manuell handkompression vid bedömning av venös insufficiens i Vena saphena magna." Thesis, Örebro universitet, Hälsoakademin, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-15784.

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Bakgrund: Venduplex har på senare år vuxit fram som den mest använda metoden vid diagnostik av venös insufficiens eftersom det är en ofarlig, kostnadseffektiv, non-invasiv metod med hög sensitivitet och specificitet där både den anatomiska placeringen av insufficiensen samt den funktionella förändringen av venen kan påvisas direkt vid undersökningen. Olika manövrar kan genomföras för att påfresta venklaffarna och därmed framkalla en eventuell reflux, men det är oklart om de olika manövrerna kan påverka den reflux som provoceras fram och därmed också påverkar bedömningen av insufficiensgraden.

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27

Combs, Austin. "Cadaveric Endoscopic Gastrocnemius Recession Procedures to Identify Vital Anatomical Structures and Limit Intraoperative and Post-Operative Complications." Otterbein University Distinction Theses / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=otbndist1620461800775256.

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28

Beteli, Camila Baumann. "Estudo randomizado duplo-cego comparativo entre eletrocoagulação e radiofrequência no tratamento de pacientes portadores de insuficiência de veia safena magna e varizes dos membros inferiores." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/98/98131/tde-15012018-080533/.

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Introdução: A termoablação vem substituindo a cirurgia convencional no tratamento cirúrgico do refluxo da veia safena magna em pacientes portadores de varizes dos membros inferiores. Contudo, a termoablação apresenta elevados custos. A Eletrocoagulação endovenosa pode, seletivamente e de forma segura, causar necrose da parede da veia safena magna, mas seus resultados clínicos nunca foram estudados previamente. O objetivo deste estudo é comparar a Eletrocoagulação e a Radiofrequência no tratamento da insuficiência da veia safena magna, considerando eficácia, complicações e impacto na qualidade

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29

Metzger, Patrick Bastos. "Ultrassonografia vascular comparada à intravascular no diagnóstico das obstruções venosas ilíacas em portadores de insuficiência venosa crônica." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/98/98131/tde-26042016-095157/.

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Introdução: O tratamento da Insuficiência Venosa Crônica (IVC) é baseado na correção dos refluxos e obstruções ao fluxo sanguíneo venoso. A detecção, a gravidade e o tratamento dessas obstruções venosas, responsáveis pelos sinais e sintomas da IVC, têm sido recentemente estudados e melhor compreendidos. Estes estudos não definem qual o grau de obstrução significativa nem os critérios ultrassonográficos para sua detecção. O objetivo deste estudo foi determinar critérios ultrassonográficos para o diagnóstico das obstruções venosas ilíacas, avaliando a concordância deste método com o ultrassom in

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30

Fecuri, Junior Rubens. "Estudo da pressão venosa nas pernas ao final da gestação." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309252.

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Orientadores: Fabio Husemann Menezes, João Poterio Filho<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-07T12:22:37Z (GMT). No. of bitstreams: 1 FecuriJunior_Rubens_M.pdf: 5719185 bytes, checksum: e083a35f4647757fb28a54278b9718c6 (MD5) Previous issue date: 2006<br>Resumo: Introdução- A gestação é considerada como fator de desenvolvimento de varizes nas pernas e um dos fatores supostamente responsável por isso, seria o aumento de pressão nas veias das pernas devido ao aumento do útero e compressão das veias i

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31

Deus, Kleber Gontijo de. "Estudo randomizado de dois tipos de incisão para safenectomia em pacientes submetidos a revascularização miocárdica." Universidade Federal de Uberlândia, 2015. https://repositorio.ufu.br/handle/123456789/12848.

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Objective: Compare the evolution regarding the complications concerning two types of incision (conventional x mini-incision), for saphenectomy in patients that go under myocardial revascularization or otherwise known as coronary artery bypass surgery. Methods: During the period from January 2012 to August 2013, 66 patients were prospectively selected for coronary artery bypass with cardiopulmonary bypass surgery. These were divided into two groups: Conventional and Mini-Incision, with 33 patients in each group chosen in a random fashion and with knowledge of which technique to be used being pr

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Santos, Jorgete Barreto dos. "Ecoescleroterapia com espuma de polidocanol em veia safena magna com cateter curto versus cateter longo com tumescência: ensaio clínico randomizado." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5132/tde-21032019-100309/.

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INTRODUÇÃO: A ecoescleroterapia com espuma (EEE) é um método minimamente invasivo de tratamento das varizes dos membros inferiores. Suas principais vantagens são a indicação para pacientes com alto risco cirúrgico, recuperação precoce pós-intervenção e menor custo inicial em relação aos outros métodos endovenosos. Porém, a taxa de oclusão venosa é variável, especialmente para o eixo venoso troncular com diâmetro maior que 6 mm. OBJETIVO: Comparar duas técnicas de EEE de polidocanol a 3% em veia safena magna (VSM) insuficiente, tendo como desfecho primário a taxa de sucesso completo com uma ses

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33

Campos, Luciene Cristina Gastalho. "Identificação e caracterização de proteínas modificadas em enxertos de veias safenas humanas arterializadas no modelo ex vivo." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5131/tde-16122008-174047/.

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A revascularização cardíaca utilizando a ponte de safena é um procedimento bastante utilizado para restabelecer o fluxo coronariano. Apesar do sucesso deste procedimento, a patência deste enxerto pode chegar a menos de 50% em 10 anos. Atribui-se parte deste insucesso a variações no processo adaptativo à nova condição hemodinâmica, onde o shear stress e o estiramento aumentados podem estar interferindo na função endotelial e vascular. Este processo envolve a participação de diversas proteínas e o estudo de como elas participam conjuntamente é uma importante abordagem para entender as alterações

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34

Borin, Thaiz Ferraz. "Aumento da IL-1beta no processo de arterialização de enxertos venosos utilizando modelos ex vivo, in vitro e in vivo." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5131/tde-29012009-132853/.

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A revascularização cardíaca utilizando a ponte de safena é um procedimento bastante comum usado para restabelecer o fluxo coronariano. O sucesso do implante depende da adaptação do vaso que estava em um regime hemodinâmico venoso, e passa subitamente para um regime arterial. Durante este processo adaptativo, ocorrem diversas alterações moleculares cujo conhecimento pode fornecer alternativas de melhoramento da patência dos enxertos venosos em leito arterial. Neste trabalho está sendo investigada a regulação da IL-1beta tanto em veia safena humana como em modelo animal de arterialização venosa.

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35

Swenne, Christine Leo. "Wound Infection Following Coronary Artery Bypass Graft Surgery : Risk Factors and the Experiences of Patients." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7168.

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Neumann, Gesa. "Die Bedeutung voraktivierter Monozyten bei ihrer Adhäsion an humane Aorten-, Saphenavenen-, Umbilikalarterien- und Umbilikalvenenendothelzellen und die Untersuchung der Superoxidausschüttung von Endothel und Monozyten bei Patienten mit arterieller Hypertonie und gesunden Kontrollpersonen im Vergleich." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2004. http://dx.doi.org/10.18452/15159.

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Einführung - Periphere Blutmonozyten spielen eine Rolle in der Pathogenese der Arteriosklerose. Bei spontan hypertensiven Ratten wurden im Vergleich zu normotonen Wistar-Kyoto-Ratten signifikant erhöhte Zahlen aktivierter Monozyten beobachtet [Liu 1996]. Wir untersuchten Monozyten von Patienten mit essentieller Hypertonie und von gesunden Probanden hinsichtlich möglicher Unterschiede in der Aktivierung anhand ihrer Adhäsion an von uns kultivierte (HAEC) und isolierte (HSVEC, HUVEC, HUAEC) humane Endothelzellen. Wir bestimmten die Adhäsionsmoleküle ICAM-1, VCAM-1 sowie E-Selektin und analysiert

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37

Wang, Zhiping. "Increased contractility in antigen-sensitized canine saphenous vein." 1989. http://hdl.handle.net/1993/16954.

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38

Crowley, Christine Maureen. "Excitation-contraction coupling in the human saphenous vein." Thesis, 2002. http://hdl.handle.net/2429/12975.

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Background: Human vascular preparations are most suitable to study vascular physiology and pathophysiology. Fresh tissues are difficult to obtain and may be damaged from the surgical procedure, limiting their use or introducing variability in the experimental findings. The purpose of this study was two-fold: (1) to demonstrate that a functional human saphenous vein (HSV) preparation may be obtained from coronary artery revascularisation procedures; (2) to elucidate excitation-contraction coupling mechanisms in functionally intact segments of HSV. Methods: Isometric contraction experiment

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39

Li, Jun [Verfasser]. "Pre-existing intimal hyperplasia and overexpression of TGF-β1 [TGF-beta-1] in saphenous vein grafts before myocardial revascularization in humans : implications for aortocoronary saphenous vein graft disease / presented by Jun Li". 2001. http://d-nb.info/1001068564/34.

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40

"Novel vascular markers and therapeutic strategies for the prevention of vein graft failure in a pig model of carotid artery-saphenous vein interposition grafting." 2009. http://library.cuhk.edu.hk/record=b5894197.

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Kang, Ning.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2009.<br>Includes bibliographical references.<br>Abstract also in Chinese.<br>Abstracts --- p.i<br>Abbreviations --- p.v<br>List of Figures and Tables --- p.vii<br>Contents --- p.viii<br>Chapter Chapter 1: --- Introduction --- p.1<br>Chapter 1. --- Saphenous vein graft patency after coronary artery bypass grafting --- p.1<br>Chapter 2. --- Mechanism of vein graft failure and therapeutic strategies --- p.8<br>Chapter 2.1 --- Mechanism --- p.15<br>Chapter 2.2 --- Therapeutic strategies --- p.18<br>Chapter 3. --- Summary -

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41

Brass, Margaret Mary. "Biomechanical and morphological characterization of common iliac vein remodeling: Effects of venous reflux and hypertension." Thesis, 2014. http://hdl.handle.net/1805/5278.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>The passive properties of the venous wall are important in the development of venous pathology. Increase in venous pressure due to retrograde flow (reflux) and obstruction of venous flow by intrinsic and extrinsic means are the two possible mechanisms for venous hypertension. Reflux is the prevailing theory in the etiology of venous insufficiency. The objective of this thesis is to quantify the passive biomechanical response and structural remodeling of veins subjected to chronic venous reflux and hypertension. To investigate the eff

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Roberts, A. C., J. Gohil, L. Hudson, et al. "Aberrant Phenotype in Human Endothelial Cells of Diabetic Origin: Implications for Saphenous Vein Graft Failure?" 2015. http://hdl.handle.net/10454/10083.

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yes<br>Type 2 diabetes (T2DM) confers increased risk of endothelial dysfunction, coronary heart disease, and vulnerability to vein graft failure after bypass grafting, despite glycaemic control. This study explored the concept that endothelial cells (EC) cultured from T2DM and nondiabetic (ND) patients are phenotypically and functionally distinct. Cultured human saphenous vein- (SV-) EC were compared between T2DM and ND patients in parallel. Proliferation, migration, and in vitro angiogenesis assays were performed; western blotting was used to quantify phosphorylation of Akt, ERK, and eNOS. Th

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Alshanwani, A. R., Kirsten Riches-Suman, D. J. O'Regan, I. C. Wood, N. A. Turner, and K. E. Porter. "MicroRNA‐21 drives the switch to a synthetic phenotype in human saphenous vein smooth muscle cells." 2018. http://hdl.handle.net/10454/16246.

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Yes<br>Cardiovascular disease is a leading cause of morbidity and mortality. Smooth muscle cells (SMC) comprising the vascular wall can switch phenotypes from contractile to synthetic, which can promote the development of aberrant remodelling and intimal hyperplasia (IH). MicroRNA‐21 (miR‐21) is a short, non‐coding RNA that has been implicated in cardiovascular diseases including proliferative vascular disease and ischaemic heart disease. However, its involvement in the complex development of atherosclerosis has yet to be ascertained. Smooth muscle cells (SMC) were isolated from human saphenou

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Chiu, Kuan-Ming, and 邱冠明. "The Clinical Advantages and Disadvantages of Endoscopic Saphenous Vein Harvest – Technique Refinement and Study of Endothelial Function." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/38214735552312381687.

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Jackson, C. D., K. Barnes, Shervanthi Homer-Vanniasinkam, and A. J. Turner. "Expression and localization of human endothelin-converting enzyme-1 isoforms in symptomatic atherosclerotic disease and saphenous vein." 2006. http://hdl.handle.net/10454/3922.

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No<br>Endothelln-converting enzyme (ECE-1) is a critical enzyme in the production of the potent vasoconstrictor peptide endothelin (ET-1). It has previously been shown that the levels of both ET-1 and ECE-1 are raised in atherosclerosis, but the possible relevance of the isoforms of ECE-1 in these changes has not yet been investigated. The aim of this study was to examine the expression of the ECE-1a and ECE-1c isoforms in human atherosclerotic pathologies. Immunohistochemical analysis was carried out on sections from atherosclerotic and non-atherosclerotic vascular tissue using a combination

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Urquhart, Paula, Susan M. Parkin, J. S. Rogers, J. A. Bosley, and Anna Nicolaou. "The effect of conjugated linoleic acid on arachidonic acid metabolism and eicosanoid production in human saphenous vein endothelial cells." 2002. http://hdl.handle.net/10454/3749.

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No<br>The effects of a conjugated linoleic acid (CLA) mixture of single isomers (50:50, w/w, cis9,trans11:trans10,cis12) and the individual isomers on (a) the production of resting and calcium ionophore stimulated 14C-eicosanoids and (b) the incorporation of 14C-arachidonic acid (AA) into membrane phospholipids of human saphenous vein endothelial cells were investigated. The CLA mixture and the individual isomers were found to inhibit resting production of 14C-prostaglandin F2a by 50, 43 and 40%, respectively. A dose dependent inhibition of stimulated 14C-prostaglandins was observed with the C

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Riches-Suman, Kirsten, J. Huntriss, C. Keeble, et al. "Mapping the methylation status of the miR-145 promoter in saphenous vein smooth muscle cells from individuals with type 2 diabetes." 2016. http://hdl.handle.net/10454/11032.

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yes<br>Type 2 diabetes mellitus prevalence is growing globally, and the leading cause of mortality in these patients is cardiovascular disease. Epigenetic mechanisms such as microRNAs (miRs) and DNA methylation may contribute to complications of type 2 diabetes mellitus. We discovered an aberrant type 2 diabetes mellitus–smooth muscle cell phenotype driven by persistent up-regulation of miR-145. This study aimed to determine whether elevated expression was due to changes in methylation at the miR-145 promoter. Smooth muscle cells were cultured from saphenous veins of 22 non-diabetic and 2

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Riches-Suman, Kirsten, A. R. Alshanwani, P. Warburton, et al. "Elevated expression levels of microRNA-143/5 in saphenous vein smooth muscle cells from patients with type 2 diabetes drive persistent changes in phenotype and function." 2014. http://hdl.handle.net/10454/10084.

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yes<br>Type 2 diabetes (T2DM) promotes premature atherosclerosis and inferior prognosis after arterial reconstruction. Vascular smooth muscle cells (SMC) respond to patho/physiological stimuli, switching between quiescent contractile and activated synthetic phenotypes under the control of microRNAs (miRs) that regulate multiple genes critical to SMC plasticity. The importance of miRs to SMC function specifically in T2DM is unknown. This study was performed to evaluate phenotype and function in SMC cultured from non-diabetic and T2DM patients, to explore any aberrancies and investigate underlyi

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Riches-Suman, Kirsten, P. Warburton, D. J. O'Regan, N. A. Turner, and K. E. Porter. "Type 2 diabetes impairs venous, but not arterial smooth muscle cell function: possible role of differential RhoA activity." 2014. http://hdl.handle.net/10454/10086.

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yes<br>Background/purpose Coronary heart disease is the leading cause of morbidity in patients with type 2 diabetes mellitus (T2DM), frequently resulting in a requirement for coronary revascularization using the internal mammary artery (IMA) or saphenous vein (SV). Patency rates of SV grafts are inferior to IMA and further impaired by T2DM whilst IMA patencies appear similar in both populations. Smooth muscle cells (SMC) play a pivotal role in graft integration; we therefore examined the phenotype and proliferative function of IMA- and SV-SMC isolated from non-diabetic (ND) patients or those

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Δαμέλου, Αναστασία. "Η εκτίμηση με οπτική συνεκτική τομογραφία των ένοχων βλαβών μοσχευμάτων ασθενών με οξύ στεφανιαίο σύνδρομο και προηγηθείσα αορτοστεφανιαία παράκαμψη". Thesis, 2013. http://hdl.handle.net/10889/6231.

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Στο συγκεκριμένο ερευνητικό πρωτόκολλο μελετήθηκαν οι πιθανές ένοχες βλάβες σε φλεβικά μοσχεύματα ασθενών με οξέα στεφανιαία σύνδρομα με τη μέθοδο της Οπτικής Συνεκτικής Τομογραφίας (OCT). • Οι αθηροσκληρωτικές βλάβες των φλεβικών μοσχευμάτων έχουν μελετηθεί in vivo με τη μέθοδο της αγγειοσκόπησης και της ενδαγγειακής υπερηχογραφίας (IVUS). Απεναντίας, η απεικόνιση των μοσχευμάτων με τη μέθοδο της OCT, η οποία χαρακτηρίζεται από σημαντικά μεγαλύτερη διακριτική ικανότητα σε σχέση με το IVUS και βελτιωμένη διεισδυτική ικανότητα συγκρινόμενη με την αγγειοσκόπηση, δεν έχει μελετηθεί συστηματικά.

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