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Dissertations / Theses on the topic 'Immune response genes'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 July 2024

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1

Aldred, Patricia M. R. "Variation in human immune response genes." Thesis, University of Nottingham, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415720.

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2

Lorenzi, Roberto. "Studies on gene conversion as a mutational mechanism in the evolution of major histocompatibility complex genes." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336766.

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3

Milner, Caroline M. "Characterisation of novel genes in the human major histocompatibility complex : the HSP70 & G9a genes." Thesis, University of Oxford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302867.

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4

Ghaffari, Emma Louise Marie. "Early growth response genes -2 and -3 are essential for optimal immune responses." Thesis, Brunel University, 2013. http://bura.brunel.ac.uk/handle/2438/8134.

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Early Growth Response Genes (EGR) is a family of four transcription factors containing a unique zinc finger domain. EGR-2 and EGR-3 are important for hindbrain development and myelination. These transcription factors are also necessary for lymphocyte function however, the mechanisms are still unclear. Previous findings have shown that EGR-2cKO mice develop lupus-like autoimmune disease with high levels of pro-inflammatory cytokines despite showing normal T and B cell proliferation after mitogenic stimulation. Therefore we established the CD2-EGR-2-/-EGR-3-/- mouse model to explore the phenotyp

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5

Kendall, Elaine. "Molecular characterisation of the human major histocompatibility complex." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333402.

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6

O'Neill, Ann Marie Ewald Sandra J. "Polymorphism in chicken immune response genes and resistance to disease." Auburn, Ala., 2007. http://repo.lib.auburn.edu/2007%20Fall%20Dissertations/O'Neill_Ann_48.pdf.

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7

Daniels, Garry D. "Cloning and characterisation of cytokine and cytokine receptor genes in rainbow trout, Oncorhynchus mykiss." Thesis, University of Aberdeen, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265893.

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Convincing molecular evidence for the existence of both cytokines and their receptors in teleost fish is presented. TGF-β is present in <I>O. mykiss</I> encoding a 112 amino acid mature peptide. An integrin binding site (RGD) and a characteristic tetrabasic cleavage site (RKKR) are present, as is the TGF-β superfamily motif. The mature peptide has 9 conserved cysteine residues (8 of which occur in pairs) as well as two additional conserved TGF-β superfamily residues (Pro<sub>36</sub> and Gly<sub>46</sub>). TGF-β exhibits a wide range tissue distribution including head-kidney macrophages, PBL,

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8

Emonts, M. "Polymorphisms in immune response genes in infectious diseases and autoimmune diseases." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2008. http://hdl.handle.net/1765/14316.

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9

Modesto, P. "EXPRESSION PROFILE OF IMMUNE RESPONSE GENES IN GOATS WITH EXPERIMENTALLY INDUCED STAPHYLOCOCCUS AUREUS MASTITIS." Doctoral thesis, Università degli Studi di Milano, 2012. http://hdl.handle.net/2434/169565.

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Counteracting infectious diseases of farm animals are an everlasting challenge in food production from livestock and preserving the health of farm animals is highly relevant to maintaining high standards of food quality. Clinical mastitis (CM) is the primary health reason for involuntary culling in dairy small ruminants and causes additional economic losses from costs of veterinary treatments. Complementary strategies are needed, since the classical prophylactic measures sometimes appear too demanding to breeders in terms of time and care, and efficient vaccination against the main pathogens i

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MAGRO, GIADA. "BOVINE STAPHYLOCOCCUS AUREUS MASTITIS: FROM THE MAMMARY IMMUNE RESPONSE TO THE BACTERIA VIRULENCE GENES." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/548380.

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Staphylococcus aureus (S. aureus) is one of the most important bacteria in veterinary medicine. In dairy herds, it is a contagious bacterium responsible mainly for subclinical mastitis in cattle, which frequently gives rise to persistent and chronic infection. Mastitis cause considerable economic losses due to i) decreased milk production, (ii) reduced milk quality, and (iii) treatment costs. Mastitis is also a public health problem. Indeed, the strains isolated from infected glands could produce enterotoxins. Three factors interact in mastitis: the host, the pathogen and the environment. This

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11

Ahyi, Ayélé-Nati. "The role of PU.1 and IRF4 interaction in the biology and function of T helper 2 cells." Connect to resource online, 2009. http://hdl.handle.net/1805/1882.

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Thesis (Ph.D.)--Indiana University, 2009.<br>Title from screen (viewed on August 26, 2009). Department of Microbiology and Immunology, Indiana University-Purdue University Indianapolis (IUPUI). Advisor(s): Mark Kaplan. Includes vita. Includes bibliographical references (leaves 107-125).

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12

Weyer, Jacqueline. "Immune responses against recombinant poxvirus vaccines that express full-length lyssavirus glycoprotein genes." Thesis, University of Pretoria, 2006. http://hdl.handle.net/2263/28113.

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Rabies is a fatal but preventable neurotropic disease of potentially all mammals. The disease is caused by lyssaviruses. Rabies is recognized as the 10th most common lethal infectious disease in the world, rendering it one of the most feared zoonotic diseases known to man. Nevertheless, rabies can be prevented by application of pre- or post exposure treatments. Rabies vaccines have been available since the time of Pasteur, more that one hundred years ago. Since, vaccine research focused on the development of safer and more effective vaccines. Topics of current interest in the field of rabies v

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13

Rajsbaum, Ricardo. "Expression of TRIM genes in different immune cells and mechanism of regulation of their expression : implications for the immune response to pathogens." Thesis, Open University, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494626.

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The tripartite motif (TRIM) proteins are important in a variety of cellular functions including antiviral activity. We systematically analyzed mRNA expression of representative TRIMs in primary mouse macrophages, myeloid and plasmacytoid dendritic cells, and a selection of CD4+ T cell subsets. These cells have different effector functions in innate and adaptive immune responses, to a large extent due to the different patterns of cytokines that they produce. Here, we defined four clusters of TRIM genes based on their selective expression in these cell subsets. The first group of TRIMs was prefe

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14

Izadi, Shavakand Fariba. "A molecular genetic survey of immune response genes and biodiversity of industrial and non-industrial chickens." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/36959.

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The current practices in industrial poultry breeding developed specialized production lines from very few breeds, resulting in reducting in genetic diversity. “Free run/free range” production systems (non-industrial) are a more recent trend in the poultry sector. Non-industrial chicken populations may differ genetically and have more diversity in disease resistance genes than industrial populations. To test this hypothesis, six chicken populations from non-industrial source; Silkies (SK), Taiwanese Cross (TC), Shiqi (SQ), Yellow Shiqi (YSQ), Yellow Wai-Chow (YW), and Agassiz Cross (AC), and in

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15

Forni, D. "HOW NATURAL SELECTION SHAPED DIVERSITY AT IMMUNE RESPONSE GENES AND AUTOIMMUNE RISK ALLELES DURING MAMMALIAN EVOLUTION." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/279118.

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ABSTRACT INTRODUCTION Genetic diversity is generated by a combination of different evolutionary processes, including mutation, genetic drift, migration, and natural selection.It is well known that natural selection acts on a specific locus\variant, whereas demographic effects act on all loci in the same way; also the selection is expected to be focused on genomic positions that have a functional role. Importantly, the selected variants targeted by selection may not only have a functional role but can correlate with predisposition or protection to some specific diseases. They can therefore

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Denadai, Janine. "Infecção de aves (Gallus gallus domesticus) com Salmonella enterica subesp. enterica sorovar Enteritidis contendo deleções nos genes cobS, cbiA, pduC, pduD e pduE : avaliação da colonização intestinal, invasão sistêmica e resposta imune /." Jaboticabal, 2015. http://hdl.handle.net/11449/127833.

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Orientador: Angelo Berchieri Junior<br>Coorientador: Oliveiro Caetano de Freitas Neto<br>Banca: Marcelo Brocchi<br>Banca: Jacqueline Boldrin de Paiva<br>Banca: Rosemeri de Oliveira Vasconcelos<br>Banca: Karin Werther<br>Resumo: Salmonella Enteritidis (SE) é responsável pela maioria dos casos de infecções alimentares em seres humanos e, geralmente, está associada ao consumo de produtos de origem avícola. Nas aves, SE coloniza o intestino, podendo sobreviver utilizando como substrato o 1,2 propanodiol (1,2-Pd) disponível neste ambiente, cujo metabolismo é viabilizado pela ação da enzima propanod

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Denadai, Janine [UNESP]. "Infecção de aves (Gallus gallus domesticus) com Salmonella enterica subesp. enterica sorovar Enteritidis contendo deleções nos genes cobS, cbiA, pduC, pduD e pduE: avaliação da colonização intestinal, invasão sistêmica e resposta imune." Universidade Estadual Paulista (UNESP), 2015. http://hdl.handle.net/11449/127833.

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Made available in DSpace on 2015-09-17T15:25:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-04-06. Added 1 bitstream(s) on 2015-09-17T15:46:24Z : No. of bitstreams: 1 000845411.pdf: 3451364 bytes, checksum: 80e865130ecdaad0f2b3fd5d563d2863 (MD5)<br>Salmonella Enteritidis (SE) é responsável pela maioria dos casos de infecções alimentares em seres humanos e, geralmente, está associada ao consumo de produtos de origem avícola. Nas aves, SE coloniza o intestino, podendo sobreviver utilizando como substrato o 1,2 propanodiol (1,2-Pd) disponível neste ambiente, cujo metabolismo é viabil

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18

Baloglu, Simge. "Applicability of vaccinia virus as cloning and expression vector for bacterial genes: mice immune responses to vaccinia virus expressing Brucella abortus and Listeria monocytogenes antigens." Diss., Virginia Tech, 2001. http://hdl.handle.net/10919/28485.

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Previous studies by our group showed that vaccinia virus recombinants expressing Brucella abortus (BA) antigens heat shock protein GroEL, 18 kDa protein and Cu/Zn SOD, were unable to induce protective immune responses against Brucella challenge. This dissertation analyzes the possible reasons for this phenomenon, by using other genes/proteins from BA and Listeria monocytogenes (LM), various shuttle plasmids (pSC65, pSC11) and immune response modulators (CpG, IL-12, B7-1). As the first objective, a vaccinia virus recombinant (WRL7/L12), expressing the BA L7/L12 gene was generated. L7/L12 ri

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19

Chen, Yuanneng. "Role of polymorphisms in genes affecting oxidative stress and immune response in susceptibility to alcoholic liver disease." Thesis, University of Newcastle Upon Tyne, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391248.

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20

Moses, Kiriana Mihi. "A whole cord model for identification of mechanisms for the antivascular effects of DMXAA." The University of Waikato, 2007. http://hdl.handle.net/10289/2488.

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Endothelial cells form the inner lining of a blood vessel and their structure and functional integrity are important in maintenance of the vessel wall and circulatory function. These cells play key roles in immune and inflammatory reactions by regulating lymphocyte and leukocyte movement into tissues; they are also main targets for antivascular agents in cancer therapy. Endothelial cell responses to different stimuli have been previously investigated using conventional approaches, 'HUVEC in vitro culture system'. In this study an ex vivo perfusion model was constructed and utilized using whole

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21

Hughes, Travis Shane. "Naked plasmid DNA as a vector for delivery of genes to the intrathecal space: Expression and immune response." Connect to online resource, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3337108.

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22

Kongchum, Pawapol. "Isolation of innate immune response genes, expression analysis, polymorphism identification and development of genetic markers for linkage analysis in common carp (Cyprinus carpio)." Diss., Virginia Tech, 2010. http://hdl.handle.net/10919/77300.

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Since the late 1990s, common carp and koi production enterprises around the world have suffered enormous losses due to a viral disease caused by cyprinid herpesvirus-3 (CyHV-3). Genetic variation in resistance to CyHV-3 infection was observed in different common carp strains, indicating that disease resistance can be improved by selective breeding. Marker-assisted selection is a breeding strategy that can accelerate genetic gain; however, this approach requires genetic markers and a genetic linkage map. To develop molecular tools for breeding CyHV-3-resistant aquaculture stock, several candida

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23

Miller, Wyatt Austin. "Effects of molting and hyposalinity stress on the expression of HIF-a, molting, and immune response genes in juvenile Cancer magister /." Connect to title online (Scholars' Bank), 2008. http://hdl.handle.net/1794/9132.

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24

Miller, Wyatt 1980. "Effects of Molting and Hyposalinity Stress on the Expression of HIF-a, Molting, and Immune Response Genes in Juvenile Cancer magister." Thesis, University of Oregon, 2009. http://hdl.handle.net/1794/9132.

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xi, 49 p. : ill. A print copy of this thesis is available through the UO Libraries. Search the library catalog for the location and call number.<br>Molting and hyposalinity stress in crustaceans cause extensive morphological and metabolic changes. I hypothesize that injuvenile Cancer magister, which molt in nearshore and estuarine habitats, hypoxia inducible factor (HIF) participates in regulating target genes in response to molting and hyposalinity stress. This study investigated the mRNA expression ofHIF-a, cryptocyanin 2, arthrodial membrane protein 6.0, anti.. lipopolysaccharide fact

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Singh, Randeep. "Early growth response genes 2 and 3 are potent inhibitors of T-bet function for interferon gamma production in T-cells." Thesis, Brunel University, 2016. http://bura.brunel.ac.uk/handle/2438/14780.

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Early growth response (Egr) gene 2 and 3 are genes encoding transcription factors important for maintaining immune homeostasis. Here we define a fundamental role of Egr2 and 3 to control T cell proliferation and differentiation of effector T cells. Egr2 and Egr3 deficiency in T cells resulted in impaired T cell proliferation, but hyper-activation and excessive differentiation of T cells in response to viral infection, while, conversely, sustained Egr2 expression enhanced proliferation, but severely impaired effector differentiation in to T helper (Th) subsets, such as, Th1 and Th17 subtypes. T

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Jusi, Márcia Mariza Gomes [UNESP]. "Estudo da resposta imune de camundongos BALB/c com a proteína recombinante A2 de Leishmania chagasi." Universidade Estadual Paulista (UNESP), 2015. http://hdl.handle.net/11449/126394.

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Made available in DSpace on 2015-08-20T17:09:40Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-02-12. Added 1 bitstream(s) on 2015-08-20T17:26:39Z : No. of bitstreams: 1 000837650_20170101.pdf: 129928 bytes, checksum: bcf92a65a2ae8f3fe651ecb9b7e44699 (MD5) Bitstreams deleted on 2017-01-02T15:03:50Z: 000837650_20170101.pdf,. Added 1 bitstream(s) on 2017-01-02T15:05:07Z : No. of bitstreams: 1 000837650.pdf: 3998019 bytes, checksum: 27c55eb98a37acdb1cdea68262f691ce (MD5)<br>O agente etiológico da leishmaniose visceral no Brasil, é a Leishmania chagasi. Ela é transmitida pela picada do

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Jusi, Márcia Mariza Gomes. "Estudo da resposta imune de camundongos BALB/c com a proteína recombinante A2 de Leishmania chagasi /." Jaboticabal, 2015. http://hdl.handle.net/11449/126394.

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Orientador: Rosangela Zacarias Machado<br>Banca: Antonio Carlos Alessi<br>Banca: Pamela Rodrigues Reina Moreira<br>Banca: Hiro Goto<br>Banca: Trícia Maria Ferreira de Sousa Oliveira<br>Resumo: O agente etiológico da leishmaniose visceral no Brasil, é a Leishmania chagasi. Ela é transmitida pela picada do flebotomíneo Lutzomyia longipalpis, que adquire o parasito ao realizar o hematofagismo em animais infectados. O presente trabalho teve como objetivo estudar a resposta imune de camundongos BALB/c imunizados com a proteína recombinante produzido a partir do gene A2-L de L. chagasi, amostra isol

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Sirimanapong, Wanna. "Characterisation of the immune response of the striped catfish (Pangasianodon hypophthalmus, Sauvage) following immunomodulation and challenge with bacteria pathogens." Thesis, University of Stirling, 2013. http://hdl.handle.net/1893/19277.

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In Southeast Asia, the family Pangasiidae is important for commercial fisheries and aquaculture. Pangasianodon hypophthalmus (striped catfish) is the most economically important species farmed in Vietnam, with a total export value of 1.7 billion USD in 2012. Intensive aquaculture can lead to problems with major outbreaks of disease and Edwardsiella ictaluri and Aeromonas hydrophila represent two important bacterial pathogens in P. hypophthalmus aquaculture. Immunostimulants have proven to be a very useful food additive for the aquaculture industry, since they can be easily fed to fish to enhan

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Janse, van Rensburg Marike. "The role of the cytochrome B and cytochrome C oxidase III genes in the immune response of the South African abalone, Haliotis midae." Master's thesis, University of Cape Town, 2007. http://hdl.handle.net/11427/4275.

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Includes abstract.<br>Includes bibliographical references (leaves 80-89).<br>Although South Africa is the second largest producer of abalone outside Asia, the sustainability of the industry could be threatened by infectious diseases (Troell et ai., 2006). Probiotics are increasingly being viewed as an alternative to chemical and antibiotic treatments (Balcazar et al., 2006), and have been shown to improve the health of the South African abalone, Haliotis midae (Macey and Coyne, 2005). In order to establish better health management systems, and to implement alternative therapies such as probiot

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Hippolito, Daise Damaris Carnietto de. "Estudo dos genes codificadores de citocinas implicadas na modulação da leishmaniose tegumentar americana e correlação com os achados clínico-laboratoriais da doença." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/99/99131/tde-09112017-152754/.

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A resposta imune desencadeada em pacientes com leishmaniose tegumentar Americana (LTA) é predominantemente celular. Assim, o estudo dos mecanismos imunológicos responsáveis pela formação, progressão e cura desta infecção é de grande importância, considerando a deformação que ela pode causar em indivíduos infectados. Este estudo investigou a expressão de mRNA de IFN-?, IL-10, IL-27, TNF-?, TGF-? e IL-6 em 40 biopsias de parafina (FFPE) fixadas em formalina de pacientes com diagnóstico clínico e laboratorial para LTA. Um grupo de 10 biópsias FFPE coletadas de pacientes com diagnóstico clínico de

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Sukkar, Dani. "Role of Nosema cerenae and pesticides on the decline of bees : Studies using a multifactorial approach : “Tipping the scale of honeybee immune responses - The effect of pesticides on immune-stimulation mimicking Nosema spp.”." Electronic Thesis or Diss., Université de Lorraine, 2023. http://www.theses.fr/2023LORR0086.

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Les abeilles sont confrontées à la menace mondiale du syndrome d'effondrement des colonies (CCD), entraînant des décès de colonies et une diminution de leur nombre, affectant leur contribution environnementale et agronomique dans la pollinisation des plantes et des cultures commerciales, en plus de la production de miel. L'exposition aux pesticides peut être l'une des principales causes conduisant au CCD en affaiblissant le système immunitaire des abeilles et en altérant leurs réponses immunitaires. Les maladies de la nosémose causées par Nosema spp. peuvent avoir une contribution significativ

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Morampudi, Vijay. "Study of the modulation of innate immune responses in intestinal epithelial cells by Toxoplasma gondii and its correlation with parasite virulence." Doctoral thesis, Universite Libre de Bruxelles, 2010. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210009.

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Early innate response of intestinal epithelial cells is the first line defense against enteric pathogens. Toxoplasma gondii infections acquired naturally via the peroral route, encounter intestinal epithelial cells early post-infection. Although the population structure of T. gondii is known to be highly clonal, clinical strains of T. gondii have been classified into three genotypes based on their virulence. In this study we investigated whether human intestinal epithelial cell immune response to T. gondii is virulence dependent. We demonstrated distinct virulence of the three T. gondii genoty

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Ullastres, i. Coll Anna. "Adaptation in Drosophila melanogaster Natural Populations. Fitness Effects and Evolutionary History of a Natural Insertion and Molecular Effects of Several Transposable Elements on Immune-Related Genes." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/406957.

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A major challenge of modern Biology is elucidating the genetic basis of adaptation. While there are many SNP-based studies trying to elucidate the genetic basis of genotype-phenotype relationships, the role of transposable element (TE)-induced mutations is understudied. Recent evidences demonstrate that TEs are a powerful tool to identify the genetic basis of adaptive phenotypic traits. Drosophila melanogaster is a good model to study adaptation because it is original from subtropical Africa and only recently colonized out-of-Africa environments. To identify and characterize the role of severa

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Alasoo, Kaur. "Regulation of gene expression in macrophage immune response." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/263855.

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Gene expression quantitative trait loci (eQTL) mapping studies can provide mechanistic insights into the functions of disease-associated variants. However, many eQTLs are cell type and context specific. This is particularly relevant for immune cells, whose cellular function and behaviour can be substantially altered by external cues. Furthermore, understanding mechanisms behind eQTLs is hindered by the difficulty of identifying causal variants. We differentiated macrophages from induced pluripotent stem cells from 86 unrelated, healthy individuals derived as part of the Human Induced Pluripote

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Carriero, Mateus Maldonado. "Caracterização e análise de expressão dos genes das enzimas Arginase 1, Arginase 2 e Óxido Nítrico Sintase Induzível (iNOS) de Piaractus mesopotamicus em resposta à infecção por Aeromonas dhakensis." Universidade Federal de São Carlos, 2016. https://repositorio.ufscar.br/handle/ufscar/7901.

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Redwood, Alec J. "Cytokine gene expression patterns and immune responses to systemic Candida albicans infection in inbred mice." Thesis, Curtin University, 1997. http://hdl.handle.net/20.500.11937/1182.

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Aims of the research:To characterise the tissue histology and tissue distribution patterns of C. albicans during systemic murine candidiasis.To develop a reliable, reproducible and sensitive SQ-RT-PCR for the quantitation of in vivo cytokine gene transcription.To use this technique to determine the in vivo pattern of tissue specific cytokine gene expression during systemic candidiasis.To determine if cytokine gene expression patterns vary between resistant BALB/c and sensitive CBA/CaH mice during primary systemic candidiasis.To determine if differences in tissue distribution of C. albicans in

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Jones, Rebecca L. "Immune responses in hepatocellular carcinoma : potential for immunotherapy." Thesis, University of Birmingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269217.

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Cooper, Laken N. "Effects of Sleep Fragmentation on the Immune System of Zebra Finches Using Cytokine Gene Expression." TopSCHOLAR®, 2016. http://digitalcommons.wku.edu/theses/1623.

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Sleep loss is known to trigger an inflammatory response and increase serum corticosterone in both human and murine models. However, very little evidence is available on the potential effects of sleep loss in avian models. This study aims to construct a profile using cytokine gene expression data to determine how birds respond to sleep loss in a controlled environment. I investigated changes in pro-inflammatory (IL-1β and IL-6) and anti-inflammatory (IL-10) cytokine gene expression in the periphery (fat, liver, spleen, and heart) and brain (hypothalamus, hippocampus, and apical hyperpallium) in

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Redwood, Alec J. "Cytokine gene expression patterns and immune responses to systemic Candida albicans infection in inbred mice." Curtin University of Technology, School of Biomedical Sciences, 1997. http://espace.library.curtin.edu.au:80/R/?func=dbin-jump-full&object_id=10970.

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Aims of the research:To characterise the tissue histology and tissue distribution patterns of C. albicans during systemic murine candidiasis.To develop a reliable, reproducible and sensitive SQ-RT-PCR for the quantitation of in vivo cytokine gene transcription.To use this technique to determine the in vivo pattern of tissue specific cytokine gene expression during systemic candidiasis.To determine if cytokine gene expression patterns vary between resistant BALB/c and sensitive CBA/CaH mice during primary systemic candidiasis.To determine if differences in tissue distribution of C. albicans in

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Mehta, Ninad T. "Early Epigenetic Regulation of the Adaptive Immune Response Gene CIITA." Digital Archive @ GSU, 2010. http://digitalarchive.gsu.edu/biology_theses/24.

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The precise regulation of Major Histocompatibility class II (MHC-II) genes plays an important role in the control of the adaptive immune response. MHC-II genes are expressed constitutively in only a few cell types, but their expression can be induced by the inflammatory response cytokine interferon gamma (INF-γ). The regulation of MHC-II is controlled by a Master Regulator, the class II transactivator (CIITA). Multiple studies have shown that CIITA regulated expression of MHC-II is controlled and induced by INF-γ. It has been also shown that a functional CIITA gene is necessary for the express

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Romero, Claudia. "CELLULAR IMMUNE RESPONSE AND GENE EXPRESSION PROFILING IN CROHN'S DISE." Doctoral diss., University of Central Florida, 2004. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/2704.

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Despite the chronic debate in the etiology of crohn's disease (cd), a debilitating inflammatory bowel disease (ibd) closely related to ulcerative colitis (uc), an emerging interest in a possible mycobacterial role has been marked. Granuloma and pathologic manifestations in cd resemble aspects found in tuberculosis, leprosy and paratuberculosis. The latter, a chronic enteritis in cattle, goat, sheep and primates, which is similar to human enteritis, also known as cd, is caused by a fastidious, slow growing mycobacterium avium subspecies paratuberculosis (map). Due to the similarities between cd

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Rabquer, Brqadley James. "The Immune Response to Streptococcus pneumoniae and Pneumococcal Polysaccharides." University of Toledo Health Science Campus / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=mco1157731794.

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Engstrand, Mats. "Cellular Immune Responses to Allografts and Cytomegalovirus." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3441.

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Maripuu, Linda. "Superantigens in group A streptococcus : gene diversity and humoral immune response." Doctoral thesis, Umeå universitet, Biomedicinsk laboratorievetenskap, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-46454.

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Group A streptococcus (GAS) is a strictly human pathogen that causes infections ranging from asymptomatic carriage to the highly lethal streptococcal toxic shock syndrome (STSS). GAS are classified according to the sequence of the variable 5’ end of the emm-gene that encodes the surface associated M-protein. In the late 1980s, outbreaks of GAS infections with high rates of STSS were reported in several parts of the world, including Sweden. Superantigens (SAgs), a group of exotoxins, have been described as key mediators of STSS due to their capacity to polyclonally activate T-cells and induce a

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Williams, Kevin Jason. "NF- kB c-Rel dependent gene induction in the immune response." Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1779835231&sid=6&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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Pearce, Oliver M. T. "Controlled virus glycosylation : engineering adenoviruses as targetable stealth vectors for gene therapy." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670156.

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Ferrer, Roig Aurora. "Immune responses to dystrophin : implications for gene therapy of DMD." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395118.

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Urrutia, Alejandra. "Defining the boundaries of a healthy immune response using standardized immune monitoring tools." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066004/document.

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Le projet Milieu Intérieur a pour but d'identifier les facteurs génétiques et environnementaux ayant un impact sur la variabilité immunitaire naturelle. Cette analyse multiparamétrique requière néanmoins d'utiliser des outils standardisés. Afin d'étudier la réponse immune induite, nous avons utilisé un système optimisé prêt à l'emploi de stimulation du sang et développé un protocole unique de quantification de l'ARN afin d'étudier la signature transcriptionnelle en réponse à des immuno-modulateurs. Testant l'hypothèse que la réponse à des composés complexes peut être définie par la signature A

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Reichel, Felix Friedrich Lambert [Verfasser]. "Immune response to ocular gene therapy with AAV8 / Felix Friedrich Lambert Reichel." Tübingen : Universitätsbibliothek Tübingen, 2020. http://d-nb.info/1222510952/34.

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Sun, Huaichang. "Characterisation of immune responses to African swine fever virus-encoded antigens." Thesis, University of Hertfordshire, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260800.

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