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Journal articles on the topic 'Immune response genes'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 July 2024

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1

Du, Liping, Aize Kijlstra, and Peizeng Yang. "Immune Response Genes in Uveitis." Ocular Immunology and Inflammation 17, no. 4 (2009): 249–56. http://dx.doi.org/10.1080/09273940902999356.

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Cox, Diane W. "Genes of the immune response: disease associations." Genome 31, no. 2 (1989): 1085–86. http://dx.doi.org/10.1139/g89-186.

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3

Béhar, Ghislaine, Yves Bourlet, Nancy Fréchin, François Guillemot, Rima Zoorob, and Charles Auffray. "Molecular analysis of chicken immune response genes." Biochimie 70, no. 7 (1988): 909–17. http://dx.doi.org/10.1016/0300-9084(88)90232-5.

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Hartman, Zachary, Xiao Yi Yang, Gangjun Lei, et al. "Modulation of adenoviral vector immune responses through the over-expression of immune adaptor and viral immuno-modulatory genes (48.17)." Journal of Immunology 178, no. 1_Supplement (2007): S77—S78. http://dx.doi.org/10.4049/jimmunol.178.supp.48.17.

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Abstract For the past two decades, adenoviral vector platforms have been used as both gene therapy vehicles and vaccine platforms in various human clinical trials. However, the use of these, as well as other viral vector platforms, has been tempered by the innate immune and adaptive immune responses elicited. Despite the development of advanced generation adenoviral vectors, the innate responses precipitated by these vectors have remained largely unchanged due to the particular nature of the viral capsid and infectious process. To more effectively use these vectors for different purposes, we c

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Knapek, Katie J., Hanah M. Georges, Hana Van Campen, et al. "Fetal Lymphoid Organ Immune Responses to Transient and Persistent Infection with Bovine Viral Diarrhea Virus." Viruses 12, no. 8 (2020): 816. http://dx.doi.org/10.3390/v12080816.

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Bovine Viral Diarrhea Virus (BVDV) fetal infections occur in two forms; persistent infection (PI) or transient infection (TI), depending on what stage of gestation the fetus is infected. Examination of lymphoid organs from both PI and TI fetuses reveals drastically different fetal responses, dependent upon the developmental stage of the fetal immune system. Total RNA was extracted from the thymuses and spleens of uninfected control, PI, and TI fetuses collected on day 190 of gestation to test the hypothesis that BVDV infection impairs the innate and adaptive immune response in the fetal thymus

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Marchalonis, John J., Peter J. Morris, and Alan W. Harris. "SPECULATIONS ON THE FUNCTION OF IMMUNE RESPONSE GENES." International Journal of Immunogenetics 1, no. 1 (2007): 63–67. http://dx.doi.org/10.1111/j.1744-313x.1974.tb00292.x.

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7

Blumenthal, M., B. Johnson, D. Marcus, et al. "558 Immune response genes of ragweed sensitive individuals." Journal of Allergy and Clinical Immunology 81, no. 1 (1988): 307. http://dx.doi.org/10.1016/0091-6749(88)90792-0.

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8

Damulewicz, Milena, Michał Świątek, Agnieszka Łoboda, et al. "Daily Regulation of Phototransduction, Circadian Clock, DNA Repair, and Immune Gene Expression by Heme Oxygenase in the Retina of Drosophila." Genes 10, no. 1 (2018): 6. http://dx.doi.org/10.3390/genes10010006.

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The daily expression of genes and the changes in gene expression after silencing the heme oxygenase (ho) gene were examined in the retina of Drosophila using microarray and SybrGreen qPCR (quantitative polymerase chain reaction) methods. The HO decrease in the morning upregulated 83 genes and downregulated 57 genes. At night, 80 genes were upregulated and 22 were downregulated. The top 20 genes downregulated after ho silencing in the morning modulate phototransduction, immune responses, autophagy, phagocytosis, apoptosis, the carbon monoxide (CO) response, the oxidative stress/UV response, and

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Hsu, S. D., C. K. Anders, C. R. Acharya, et al. "Immune signatures hold prognostic import across solids tumors." Journal of Clinical Oncology 25, no. 18_suppl (2007): 21041. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.21041.

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21041 Background: The host immune response can impact cancer growth, prognosis, and response to therapy. In colorectal cancer, the presence of cells involved with T-cell mediated adaptive immunity better predicts of survival than the current staging method. Immune signatures based on host response to cancer have the potential to predict prognosis and facilitate target specific therapy. Methods: We used the gene expression data associated with immune host response to colorectal cancer (Galon et al., Science 2006) to perform hierarchical clustering of solid tumors for which the clinical annotati

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Wu, Louisa P., Kwang-Min Choe, Yiran Lu, and Kathryn V. Anderson. "Drosophila Immunity: Genes on the Third Chromosome Required for the Response to Bacterial Infection." Genetics 159, no. 1 (2001): 189–99. http://dx.doi.org/10.1093/genetics/159.1.189.

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Abstract We have screened the third chromosome of Drosophila melanogaster for mutations that prevent the normal immune response. We identified mutant lines on the basis of their failure to induce transcription of an antibacterial peptide gene in response to infection or their failure to form melanized clots at the site of wounding. These mutations define 14 genes [immune response deficient (ird) genes] that have distinct roles in the immune response. We have identified the molecular basis of several ird phenotypes. Two genes, scribble and kurtz/modulo, affect the cellular organization of the f

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Mikhailova, Svetlana V., and Dinara E. Ivanoshchuk. "Innate-Immunity Genes in Obesity." Journal of Personalized Medicine 11, no. 11 (2021): 1201. http://dx.doi.org/10.3390/jpm11111201.

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The main functions of adipose tissue are thought to be storage and mobilization of the body’s energy reserves, active and passive thermoregulation, participation in the spatial organization of internal organs, protection of the body from lipotoxicity, and ectopic lipid deposition. After the discovery of adipokines, the endocrine function was added to the above list, and after the identification of crosstalk between adipocytes and immune cells, an immune function was suggested. Nonetheless, it turned out that the mechanisms underlying mutual regulatory relations of adipocytes, preadipocytes, im

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12

Tsuchiya, Naoyuki, Jun Ohashi, and Katsushi Tokunaga. "Variations in immune response genes and their associations with multifactorial immune disorders." Immunological Reviews 190, no. 1 (2002): 169–81. http://dx.doi.org/10.1034/j.1600-065x.2002.19013.x.

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13

Meeks, Michael D., Terri K. Wade, Ronald K. Taylor, and William F. Wade. "Immune Response Genes Modulate Serologic Responses to Vibrio cholerae TcpA Pilin Peptides." Infection and Immunity 69, no. 12 (2001): 7687–94. http://dx.doi.org/10.1128/iai.69.12.7687-7694.2001.

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ABSTRACT Cholera is an enteric disease caused by Vibrio cholerae. Toxin-coregulated pilus (TCP), a type 4 pilus expressed by V. cholerae, is a cholera virulence factor that is required for host colonization. The TCP polymer is composed of subunits of TcpA pilin. Antibodies directed against TcpA are protective in animal models of cholera. While natural or recombinant forms of TcpA are difficult to purify to homogeneity, it is anticipated that synthesized TcpA peptides might serve as immunogens in a subunit vaccine. We wanted to assess the potential for effects of the immune response (Ir) gene t

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worku, Mulumebet, Bahrath Kumar, and Hamid Ismail. "Differential Expression of Cow Innate and Adaptive Responses Genes in Response to Eugenol." Journal of Animal Science 99, Supplement_2 (2021): 31–32. http://dx.doi.org/10.1093/jas/skab096.056.

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Abstract Dietary phytochemicals have both nutritional and health benefits for farm animals. Research on the immunomodulatory effects of phytochemicals may aid in developing novel therapeutic agents and provide insights into the regulation of gene expression. Eugenol (4-allyl-2-methoxyphenyl) is the active ingredient in clove oil that has been studied for its immunomodulatory/anti-inflammatory effects. The objective of this study was to evaluate the effect of eugenol on the expression of genes associated with the cow’s innate and adaptive immune responses. Blood was collected from (n = 3) clini

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Inman, R. D. "Immunogenetic aspects of host immune response." Canadian Journal of Microbiology 34, no. 3 (1988): 319–22. http://dx.doi.org/10.1139/m88-058.

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The central role of histocompatibility leukocyte antigens (HLA) class II molecules in antigen presentation has received great attention in recent years, yet class I molecules have been defined as primarily functioning as a restriction element for cytotoxic T cell killing of virus-infected cells. Extensive clinical evidence, however, indicates that the HLA class I genes are strongly associated with nonseptic complications of enteric and genitourinary bacterial infections. Ninety percent of patients with Reiter's syndrome and reactive arthritis are positive for HLA-B27, yet the mechanism of dise

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Fijarczyk, Anna, Katarzyna Dudek, Marta Niedzicka, and Wiesław Babik. "Balancing selection and introgression of newt immune-response genes." Proceedings of the Royal Society B: Biological Sciences 285, no. 1884 (2018): 20180819. http://dx.doi.org/10.1098/rspb.2018.0819.

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The importance of interspecific introgression as a source of adaptive variation is increasingly recognized. Theory predicts that beneficial genetic variants cross species boundaries easily even when interspecific hybridization is rare and gene flow is strongly constrained throughout the genome. However, it remains unclear whether certain classes of genes are particularly prone to adaptive introgression. Genes affected by balancing selection (BS) may constitute such a class, because forms of BS that favour novel, initially rare alleles, should facilitate introgression. We tested this hypothesis

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Kumar, Neeraj, Gurvinder Kaur, and Narinder Mehra. "Genetic determinants of Type 1 diabetes: immune response genes." Biomarkers in Medicine 3, no. 2 (2009): 153–73. http://dx.doi.org/10.2217/bmm.09.7.

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Howell, M. D., B. E. Kim, and D. Y. Leung. "Immunomodulatory Effect of Rapamycin on Innate Immune Response Genes." Journal of Allergy and Clinical Immunology 123, no. 2 (2009): S33. http://dx.doi.org/10.1016/j.jaci.2008.12.1070.

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Shleptsova, V. A., E. V. Trushkin, O. A. Bystryh, et al. "Expression of Early Immune Response Genes during Physical Exercise." Bulletin of Experimental Biology and Medicine 149, no. 1 (2010): 89–92. http://dx.doi.org/10.1007/s10517-010-0883-6.

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Nepom, Gerald T. "The Effects of Variations in Human Immune-Response Genes." New England Journal of Medicine 321, no. 11 (1989): 751–52. http://dx.doi.org/10.1056/nejm198909143211108.

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Pignata, Claudio, and Rosa Romano. "In This Issue: FOX Genes and the Immune Response." International Reviews of Immunology 33, no. 2 (2014): 81–82. http://dx.doi.org/10.3109/08830185.2014.887827.

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Mehta, Akash M., Merel Mooij, Ivan Branković, Sander Ouburg, Servaas A. Morré, and Ekaterina S. Jordanova. "Cervical Carcinogenesis and Immune Response Gene Polymorphisms: A Review." Journal of Immunology Research 2017 (2017): 1–12. http://dx.doi.org/10.1155/2017/8913860.

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The local immune response is considered a key determinant in cervical carcinogenesis after persistent infection with oncogenic, high-risk human papillomavirus (HPV) infections. Genetic variation in various immune response genes has been shown to influence risk of developing cervical cancer, as well as progression and survival among cervical cancer patients. We reviewed the literature on associations of immunogenetic single nucleotide polymorphism, allele, genotype, and haplotype distributions with risk and progression of cervical cancer. Studies on HLA and KIR gene polymorphisms were excluded

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Jin, Lei, Lin Deng, and Wanchun Wang. "Candidate Genes of Allergic Dermatitis Are Associated with Immune Response." Journal of Healthcare Engineering 2022 (January 4, 2022): 1–11. http://dx.doi.org/10.1155/2022/8745722.

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Allergic dermatitis (AD) is a common and burdensome inflammatory skin disease, and diagnosis is challenging. This study was conducted to identify candidate genes for AD diagnosis and underlying molecular mechanisms. Gene expression profiles were obtained from datasets GSE121212, GSE130588, and GSE157194. Use differential analysis to identify differentially expressed genes (DEGs) between AD and control. Use enrichment analysis to identify potential molecular dysregulation mechanisms. Comprehensive least absolute shrinkage and selection operator (LASSO) logistic regression, receiver operator cha

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NAJİ, Ahmed Qasim, Md Mahmodul Hasan SOHEL, Saif Adil Abbood AL-JANABİ, Ghulam Asghar SAJİD, and Mehmet Ulaş ÇINAR. "Akkaraman ve Romanov Kuzularının Alveolar Makrofajlarında Lipopolisakkarit ve Lipoteikoik Asite Yanıtta İmmün İlişkili Genlerin Ekspresyon Profilinin Araştırılması." Hayvan Bilimi ve Ürünleri Dergisi 5, no. 1 (2022): 7–23. http://dx.doi.org/10.51970/jasp.1050658.

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The alveolar macrophages (AMs) are frontier of defense against foreign materials that initiate immune response in lungs. Knowledge of the expression dynamics of major immune-related genes in the alveolar macrophages in response to lipopolysaccharide (LPS) and lipoteichoic acid (LTA) challenge can help to understand disease mechanism involved in several respiratory diseases. The aim of this study was to investigate the mRNA expression of selected immune-related genes in response to lipopolysaccharide (LPS) and lipoteichoic acid (LTA) challenge in sheep alveolar macrophages in vivo. Results reve

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Fathi, Moataz, Ibrahim Al-Homidan, Gamal Rayan, Salah El-Safty, Tarek Ebeid, and Osama Abou-Emera. "Laying performance, immune response and antioxidant properties of hens segregating for naked neck and frizzle genes under low ambient temperature." Czech Journal of Animal Science 64, No. 5 (2019): 216–25. http://dx.doi.org/10.17221/221/2018-cjas.

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Major genes could be introgressed into laying hens to attenuate heat stress. However, under cold and/or moderate ambient temperature, these genes might possess different behaviour. The main objective of this study was to evaluate laying performance, immune response, and antioxidant status of native laying hens segregating for naked neck (Na) and frizzle (F) genes under low ambient temperature. Five genotypes were studied: homozygous naked neck (NaNaff), heterozygous naked neck (Nanaff), homozygous frizzle (nanaFF), heterozygous frizzle (nanaFf), and normally feathered (nanaff). The hens were r

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Alper, Scott, Sandra J. McBride, Brad Lackford, Jonathan H. Freedman, and David A. Schwartz. "Specificity and Complexity of the Caenorhabditis elegans Innate Immune Response." Molecular and Cellular Biology 27, no. 15 (2007): 5544–53. http://dx.doi.org/10.1128/mcb.02070-06.

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ABSTRACT In response to infection, Caenorhabditis elegans produces an array of antimicrobial proteins. To understand the C. elegans immune response, we have investigated the regulation of a large, representative sample of candidate antimicrobial genes. We found that all these putative antimicrobial genes are expressed in tissues exposed to the environment, a position from which they can ward off infection. Using RNA interference to inhibit the function of immune signaling pathways in C. elegans, we found that different immune response pathways regulate expression of distinct but overlapping se

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Gururajan, Murali, Alan Simmons, Trivikram Dasu, et al. "Early Growth Response Genes Regulate B Cell Development, Proliferation, and Immune Response." Journal of Immunology 181, no. 7 (2008): 4590–602. http://dx.doi.org/10.4049/jimmunol.181.7.4590.

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SONG, RAN, Igor Dozmorov, Chaoying Liang, et al. "Population diversity in transcriptional responses of macrophages to TLR7/8 signaling (IRM12P.654)." Journal of Immunology 194, no. 1_Supplement (2015): 133.13. http://dx.doi.org/10.4049/jimmunol.194.supp.133.13.

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Abstract The Toll-like receptors (TLR) of the innate immune system play a key role in the recognition of pathogens and the initiation of a robust innate immune response. Although an innate immune response is essential for resistance to pathogen infection, the magnitude and qualities of innate immune responses are quite variable in the human population. Here we performed transcriptome sequencing of monocyte-derived macrophages generated from 78 healthy individuals, including 10 replicates from repeat donors, to profile gene expression patterns in responses to TLR7/8 signaling. Extensive qualita

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Hewavisenti, Rehana V., Katrina M. Morris, Denis O’Meally, Yuanyuan Cheng, Anthony T. Papenfuss, and Katherine Belov. "The identification of immune genes in the milk transcriptome of the Tasmanian devil (Sarcophilus harrisii)." PeerJ 4 (January 12, 2016): e1569. http://dx.doi.org/10.7717/peerj.1569.

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Tasmanian devil (Sarcophilus harrisii) pouch young, like other marsupials, are born underdeveloped and immunologically naïve, and are unable to mount an adaptive immune response. The mother’s milk provides nutrients for growth and development as well as providing passive immunity. To better understand immune response in this endangered species, we set out to characterise the genes involved in passive immunity by sequencing and annotating the transcriptome of a devil milk sample collected during mid-lactation. At mid-lactation we expect the young to have heightened immune responses, as they hav

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Petit, Marine J., Matthew W. Kenaston, Oanh H. Pham, Ariana A. Nagainis, Adam T. Fishburn, and Priya S. Shah. "Nuclear dengue virus NS5 antagonizes expression of PAF1-dependent immune response genes." PLOS Pathogens 17, no. 11 (2021): e1010100. http://dx.doi.org/10.1371/journal.ppat.1010100.

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Dengue virus (DENV) disruption of the innate immune response is critical to establish infection. DENV non-structural protein 5 (NS5) plays a central role in this disruption, such as antagonism of STAT2. We recently found that DENV serotype 2 (DENV2) NS5 interacts with Polymerase associated factor 1 complex (PAF1C). The primary members of PAF1C are PAF1, LEO1, CTR9, and CDC73. This nuclear complex is an emerging player in the immune response. It promotes the expression of many genes, including genes related to the antiviral, antimicrobial and inflammatory responses, through close association wi

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Starr, Izzy, Kristina Seiffert-Sinha, Animesh A. Sinha, and Omer Gokcumen. "Evolutionary context of psoriatic immune skin response." Evolution, Medicine, and Public Health 9, no. 1 (2021): 474–86. http://dx.doi.org/10.1093/emph/eoab042.

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Abstract The skin is vital for protecting the body and perceiving external stimuli in the environment. Ability to adapt between environments is in part based on skin phenotypic plasticity, indicating evolved homeostasis between skin and environment. This homeostasis reflects the greater relationship between the body and the environment, and disruptions in this balance may lead to accumulation of susceptibility factors for autoimmune conditions like psoriasis. In this study, we examined the relationship between rapid, lineage-specific evolution of human skin and formation of psoriatic skin resp

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Waring, Ashley L., Joshua Hill, Brooke M. Allen, et al. "Meta-Analysis of Immune Induced Gene Expression Changes in Diverse Drosophila melanogaster Innate Immune Responses." Insects 13, no. 5 (2022): 490. http://dx.doi.org/10.3390/insects13050490.

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Organisms are commonly infected by a diverse array of pathogens and mount functionally distinct responses to each of these varied immune challenges. Host immune responses are characterized by the induction of gene expression, however, the extent to which expression changes are shared among responses to distinct pathogens is largely unknown. To examine this, we performed meta-analysis of gene expression data collected from Drosophila melanogaster following infection with a wide array of pathogens. We identified 62 genes that are significantly induced by infection. While many of these infection-

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Khunger, Arjun, Erin Piazza, Sarah Warren та ін. "CTLA-4 blockade and interferon-α induce proinflammatory transcriptional changes in the tumor immune landscape that correlate with pathologic response in melanoma". PLOS ONE 16, № 1 (2021): e0245287. http://dx.doi.org/10.1371/journal.pone.0245287.

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Patients with locally/regionally advanced melanoma were treated with neoadjuvant combination immunotherapy with high-dose interferon α-2b (HDI) and ipilimumab in a phase I clinical trial. Tumor specimens were obtained prior to the initiation of neoadjuvant therapy, at the time of surgery and progression if available. In this study, gene expression profiles of tumor specimens (N = 27) were investigated using the NanoString nCounter® platform to evaluate associations with clinical outcomes (pathologic response, radiologic response, relapse-free survival (RFS), and overall survival (OS)) and defi

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Stear, Michael, Sarah Preston, David Piedrafita, and Katarzyna Donskow-Łysoniewska. "The Immune Response to Nematode Infection." International Journal of Molecular Sciences 24, no. 3 (2023): 2283. http://dx.doi.org/10.3390/ijms24032283.

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Nematode infection is a major threat to the health of humans, domestic animals and wildlife. Nematodes vary in their effect on the host and in the mechanisms underlying immunity but the general features are becoming clear. There is considerable variation among individuals in resistance to infection and much of this variation is due to genetic variation in the immune response. The major histocompatibility complex has a strong influence on resistance to infection but other genes are collectively more important. Resistant individuals produce more IgA, eosinophils, IgE and mast cells than suscepti

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Collins, Natalie, Jernej Godec, Lihua Zou, Martin C. Mihm, Gad Getz, and W. Nicholas Haining. "Transcriptional Hallmarks Of Tumor Infiltrating Lymphocyte Responses To Melanoma." Blood 122, no. 21 (2013): 3491. http://dx.doi.org/10.1182/blood.v122.21.3491.3491.

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Abstract Tumor-infiltrating lymphocytes (TIL) are found in a subset of melanomas. Patients with pronounced TIL responses have an excellent prognosis, suggesting that for those patients, the infiltrating immune cells are part of an effective adaptive and/or innate response to cancer. However, the molecular features of brisk TIL infiltrates have not been analyzed in situ. Moreover, it is not clear whether the features of the immune response to melanoma are shared by other tumors. Here, we used histological grading of TIL infiltrates in melanoma samples from The Cancer Genome Atlas combined with

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Dai, Lingli, Zaixia Liu, Lili Guo, et al. "Multi-Tissue Transcriptome Study of Innate Immune Gene Expression Profiling Reveals Negative Energy Balance Altered the Defense and Promoted System Inflammation of Dairy Cows." Veterinary Sciences 10, no. 2 (2023): 107. http://dx.doi.org/10.3390/vetsci10020107.

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Negative energy balance (NEB) during the perinatal period leads to metabolic and immunological disorders in dairy cows, resulting in systemic responses and inflammation. The innate immune system is crucial for the host’s protection and inflammatory response. However, systematic research is still lacking on how NEB affects the innate immune system to alter the ’host defense capability and inflammatory response. In this investigation, raw transcriptome data of adipose, blood, endometrial, hypothalamus, and liver tissues were downloaded from a public database, cleaned, aligned, quantified, and ba

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Chandler, Luke M., Michael Rodriguez, and Keith P. Choe. "RNAi screening for modulators of an osmo-sensitive gene response to extracellular matrix damage reveals negative feedback and interactions with translation inhibition." PLOS ONE 18, no. 5 (2023): e0285328. http://dx.doi.org/10.1371/journal.pone.0285328.

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In epidermal tissues, extracellular matrices (ECMs) function as barriers between the organism and environment. Despite being at the interface with the environment, little is known about the role of animal barrier ECMs in sensing stress and communicating with cytoprotective gene pathways in neighboring cells. We and others have identified a putative damage sensor in the C. elegans cuticle that regulates osmotic, detoxification, and innate immune response genes. This pathway is associated with circumferential collagen bands called annular furrows; mutation or loss of furrow collagens causes cons

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Zhao, Xiuxin, Hanpeng Luo, Haibo Lu, et al. "RNA-Seq Analysis of Peripheral Whole Blood from Dairy Bulls with High and Low Antibody-Mediated Immune Responses—A Preliminary Study." Animals 13, no. 13 (2023): 2208. http://dx.doi.org/10.3390/ani13132208.

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Enhancing the immune response through breeding is regarded as an effective strategy for improving animal health, as dairy cattle identified as high immune responders are reported to have a decreased prevalence of economically significant diseases. The identification of differentially expressed genes (DEGs) associated with immune responses might be an effective tool for breeding healthy dairy cattle. In this study, antibody-mediated immune responses (AMIRs) were induced by the immunization of hen egg white lysozyme (HEWL) in six Chinese Holstein dairy bulls divided into high- and low-AMIR group

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Kang, Soo-Ji, Ji-Su Jun, and Kwang-Won Hong. "Transcriptome Analysis Reveals Immunomodulatory Effect of Spore-Displayed p75 on Human Intestinal Epithelial Caco-2 Cells." International Journal of Molecular Sciences 23, no. 23 (2022): 14519. http://dx.doi.org/10.3390/ijms232314519.

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Lacticaseibacillus rhamnosus GG (LGG) can promote intestinal health by modulating the immune responses of the gastrointestinal tract. However, knowledge about the immunomodulatory action of LGG-derived soluble factors is limited. In our previous study, we have displayed LGG-derived p75 protein on the spore surface of Bacillus subtilis. The objective of this study was to determine the effect of spore-displayed p75 (CotG-p75) on immune system by investigating transcriptional response of Caco-2 cells stimulated by CotG-p75 through RNA-sequencing (RNA-seq). RNA-seq results showed that CotG-p75 mai

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Ding, Shuai Dominique, Alexandre B. Leitão, Jonathan P. Day, et al. "Trans-regulatory changes underpin the evolution of the Drosophila immune response." PLOS Genetics 18, no. 11 (2022): e1010453. http://dx.doi.org/10.1371/journal.pgen.1010453.

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When an animal is infected, the expression of a large suite of genes is changed, resulting in an immune response that can defend the host. Despite much evidence that the sequence of proteins in the immune system can evolve rapidly, the evolution of gene expression is comparatively poorly understood. We therefore investigated the transcriptional response to parasitoid wasp infection in Drosophila simulans and D. sechellia. Although these species are closely related, there has been a large scale divergence in the expression of immune-responsive genes in their two main immune tissues, the fat bod

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Li, Q., J. Tang, K. Chao, and X. Gao. "P1195 Identification of immune cell infiltration and potential candidate biomarker in anti-IL 12/23 treated Crohn’s disease patients by integrated bioinformatics analysis and machine learning." Journal of Crohn's and Colitis 18, Supplement_1 (2024): i2129—i2130. http://dx.doi.org/10.1093/ecco-jcc/jjad212.1325.

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Abstract Background Variations existed in patients' responses to ustekinumab (UST) treatment in Crohn's disease (CD), but the underlying cause remains unknown1. Our objective was to investigate the involvement of immune cells and identify potential biomarkers that linked to the response to IL 12/23 inhibitors in patients with CD. Methods The analysis utilized the GSE207022 dataset, which consisted of 54 non-responders and 9 responders to UST in CD cohort (Table 1). Initially, differentially expressed genes (DEGs) were identified. Subsequently, Gene Ontology (GO) and Kyoto Encyclopedia of Genes

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Kim, J. J., V. Ayyavoo, M. L. Bagarazzi, et al. "In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen." Journal of Immunology 158, no. 2 (1997): 816–26. http://dx.doi.org/10.4049/jimmunol.158.2.816.

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Abstract Recent studies support the importance of investigating a DNA vaccination approach for the immunologic control of HIV-1. In this regard, it may be important to specifically engineer immune responses in order to improve on first generation vaccine attempts. Especially for HIV, induction of cell-mediated immunity may be an important feature for any candidate vaccine. In an attempt to engineer in vivo the enhancement of cellular immune response and to direct Ag-dependent immune response from Th2 to Th1 type, we investigated the role of codelivery of genes for IL-12 and granulocyte-macroph

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Badshah, Yasmin, Maria Shabbir, Khushbukhat Khan, and Hashaam Akhtar. "Expression Profiles of Hepatic Immune Response Genes in HEV Infection." Pathogens 12, no. 3 (2023): 392. http://dx.doi.org/10.3390/pathogens12030392.

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Hepatitis E is a liver inflammation caused by infection with the hepatitis E virus (HEV). Every year, there are an estimated 20 million HEV infections worldwide, leading to an estimated 3.3 million symptomatic cases of hepatitis E. HEV viral load has been studied about the disease progression; however, hepatic the host gene expression against HEV infection remains unknown. Methods: We identified the expression profiles of hepatic immune response genes in HEV infections. Fresh blood samples were collected from all the study subjects (130 patients and 124 controls) in 3ml EDTA vacutainers. HEV v

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Luo, Jian, Zhiqiang Wang, Fang Tang, and Kai Feng. "Immune Defense Mechanism of Reticulitermes chinensis Snyder (Blattodea: Isoptera) against Serratia marcescens Bizio." Insects 13, no. 3 (2022): 226. http://dx.doi.org/10.3390/insects13030226.

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Reticulitermes chinensis Snyder is an important pest species in China. Serratia marcescens Bizio (SM1) is a potent biological bacterium. In our lab, we found that SM1 can kill R. chinensis. To date, the interaction between R. chinensis and SM1 has not been studied. Here, we explored immune responses of R. chinensis against SM1 using transcriptome sequencing. To elucidate immune-related genes, we identified 126,153 unigenes from R. chinensis. In total, 178 immune-related differentially expressed genes (DEGs) were identified. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis showed that ma

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Luo, Hao, Gao-Lei Liu, Dan Jian, et al. "Neoadjuvant Chemotherapy Improves the Immunosuppressive Microenvironment of Bladder Cancer and Increases the Sensitivity to Immune Checkpoint Blockade." Journal of Immunology Research 2022 (July 21, 2022): 1–21. http://dx.doi.org/10.1155/2022/9962397.

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Although tumor immune microenvironment plays an important role in antitumor therapy, few studies explored the gene signatures associated with the tumor immune microenvironment of bladder cancer after neoadjuvant chemotherapy. We examined and analyzed differentially expressed genes from 9 patients with stage I-III bladder cancer by RNA immune-oncology profiling platform. After neoadjuvant chemotherapy, the expressions of 43 genes in 19 pathways and 10 genes in 5 pathways were upregulated and downregulated, respectively. Neoadjuvant chemotherapy also promoted the expression of genes related to t

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Yan, Jia, Ya jun Huang, Qing yu Huang, Peng Xia Liu, and Chang Shan Wang. "Comprehensive analysis of the correlations of S100B with hypoxia response and immune infiltration in hepatocellular carcinoma." PeerJ 10 (March 29, 2022): e13201. http://dx.doi.org/10.7717/peerj.13201.

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S100B has been found to be dysregulated in many cancers including hepatocellular carcinoma (HCC). However, the functions of S100B and its underlying mechanisms in HCC remain poorly understood, especially in the tumor microenvironment. In this study, functions enrichment analysis indicated that S100B expression was correlated with hypoxia and immune responses. We found that hypoxia could induce S100B expression in an HIF-1α-dependent manner in HepG2 cells. Luciferase reporter and ChIP-qRCR assays demonstrated that HIF-1α regulates S100B transcription by directly binding to hypoxia-response elem

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Baglivo, Sara, Fortunato Bianconi, Francesca Romana Tofanetti, et al. "Immune gene expression and bayesian network analysis in advanced non small cell lung cancer (NSCLC) patients treated with immunotherapy." Journal of Clinical Oncology 37, no. 15_suppl (2019): e20693-e20693. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e20693.

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e20693 Background: Immune checkpoint inhibitors (ICIs) have revoluzionized the therapeutic paradigm for different types of cancer including NSCLC. Clinical benefit, however, is limited to a minority of patients. The only adopted predictive biomarker, PD-L1 IHC testing, suffers from some limitations. A better understanding of biomarkers associated with response to ICIs is needed. Here, we studied immune gene expression profile and association with clinical response to immunotherapy in advanced NSCLC patients (pts) treated with ICI. Methods: A total of 37 Formalin-fixed, paraffin-embedded (FFPE)

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MANDAL, S., L. CURTIS, M. PIND, L. MURPHY, and P. WATSON. "S100A7 (psoriasin) influences immune response genes in human breast cancer." Experimental Cell Research 313, no. 14 (2007): 3016–25. http://dx.doi.org/10.1016/j.yexcr.2007.03.020.

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Wake, Claire T., and Richard A. Flavell. "Multiple mechanisms regulate the expression of murine immune response genes." Cell 42, no. 2 (1985): 623–28. http://dx.doi.org/10.1016/0092-8674(85)90119-9.

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Wang, Zhiquan, Olivia M. Depies, Sutapa Sinha, Weiguo Han, Sameer A. Parikh, and Neil E. Kay. "Aberrant Heterochromatin Silences Immune Response Genes in Chronic Lymphocytic Leukemia." Blood 142, Supplement 1 (2023): 3258. http://dx.doi.org/10.1182/blood-2023-182898.

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Introduction: Recent studies have shown that clonal B cells derived from patients with chronic lymphocytic leukemia (CLL) have altered histone modification landscapes compared to B cells from healthy controls. We have also shown that the BCR signaling pathway impacts the chromatin landscapes of CLL B cells, implicating the interaction between oncogenic signaling and epigenetic machinery in CLL (Wang et al., Blood Cancer J. 2022; Wang et al., Cancer Res (2023) 83 (7_Supplement): 4725). However, the majority of the chromatin studies in CLL concentrate on the active enhancers associated with onco

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