Academic literature on the topic 'Immunotoxicity'

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Journal articles on the topic "Immunotoxicity"

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Nakamura, Kazuichi. "Immunotoxicity study." Folia Pharmacologica Japonica 131, no. 3 (2008): 215–19. http://dx.doi.org/10.1254/fpj.131.215.

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Collinge, Mark. "Developmental immunotoxicity." Drug Metabolism and Pharmacokinetics 34, no. 1 (2019): S4. http://dx.doi.org/10.1016/j.dmpk.2018.09.019.

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Cunningham, Morven, Marco Iafolla, Yada Kanjanapan, et al. "Evaluation of liver enzyme elevations and hepatotoxicity in patients treated with checkpoint inhibitor immunotherapy." PLOS ONE 16, no. 6 (2021): e0253070. http://dx.doi.org/10.1371/journal.pone.0253070.

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Background and aims Immune checkpoint inhibitors (ICI) are increasingly used in cancer therapy. Elevated liver enzymes frequently occur in patients treated with ICI but evaluation is poorly described. We sought to better understand causes of liver enzyme elevation, investigation and management. Methods Patients treated with anti-PD-1, PDL-1 or CTLA-4 therapy in Phase I/II clinical trials between August 2012 and December 2018 were included. Clinical records of patients with significant liver enzyme elevations were retrospectively reviewed. Results Of 470 ICI-treated patients, liver enzyme eleva
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Wang, Xinge, Na Li, Mei Ma, Yingnan Han, and Kaifeng Rao. "Immunotoxicity in Vitro Assays for Environmental Pollutants under Paradigm Shift in Toxicity Tests." International Journal of Environmental Research and Public Health 20, no. 1 (2022): 273. http://dx.doi.org/10.3390/ijerph20010273.

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With the outbreak of COVID-19, increasingly more attention has been paid to the effects of environmental factors on the immune system of organisms, because environmental pollutants may act in synergy with viruses by affecting the immunity of organisms. The immune system is a developing defense system formed by all metazoans in the course of struggling with various internal and external factors, whose damage may lead to increased susceptibility to pathogens and diseases. Due to a greater vulnerability of the immune system, immunotoxicity has the potential to be the early event of other toxic ef
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Sharma, R. P. "Evaluation of Pesticide Immunotoxicity." Toxicology and Industrial Health 4, no. 3 (1988): 373–80. http://dx.doi.org/10.1177/074823378800400309.

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Immunotoxicologic effects have been reported for a number of pesticides. Since pesticides represent a large range of chemical classes, different types of chemicals may affect the complex immune system by a variety of mechanisms. A preliminary evaluation of pesticides for immunotoxicologic potential can best be incorporated in general subacute and chronic toxicity testing, with additional groups assigned for initial host-sensitivity assays. For chemicals that are possible candidates for immunotoxicity in preliminary assays, a comprehensive immunotoxicity screening has been suggested. Finally, e
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Chiappelli, Francesco, Michelle A. Kung, Pablo Villanueva, Patricia Lee, Patrick Frost, and Nerissa Prieto. "Immunotoxicity of Cocaethylene." Immunopharmacology and Immunotoxicology 17, no. 2 (1995): 399–417. http://dx.doi.org/10.3109/08923979509019759.

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SAKAGUCHI, Takehiro, Sanae SAKAGUCHI, and Yoshiro KUDO. "Immunotoxicity of Beryllium." Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) 52, no. 4 (1998): 611–17. http://dx.doi.org/10.1265/jjh.52.611.

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Putman, E., J. W. Laan, and H. Loveren. "Assessing immunotoxicity: guidelines." Fundamental and Clinical Pharmacology 17, no. 5 (2003): 615–26. http://dx.doi.org/10.1046/j.1472-8206.2003.00181.x.

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Laan, Jan Willem, and Henk Loveren. "Assessing immunotoxicity: guidelines." Fundamental and Clinical Pharmacology 19, no. 3 (2005): 329–30. http://dx.doi.org/10.1111/j.1472-8206.2005.00339.x.

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Pfau, Jean C. "Immunotoxicity of asbestos." Current Opinion in Toxicology 10 (August 2018): 1–7. http://dx.doi.org/10.1016/j.cotox.2017.11.005.

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Dissertations / Theses on the topic "Immunotoxicity"

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Karrow, Niel. "Chemical mixture immunotoxicity to rainbow trout." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0005/NQ44769.pdf.

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Bartlett, Alison. "QSAR study of immunotoxicity in antibiotics." Thesis, Liverpool John Moores University, 1995. http://researchonline.ljmu.ac.uk/5135/.

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Since their inception the B-Iactam antibiotics have become one of the most important classes of phannaceutical agents, both therapeutically and economically, in modern day usage for the treatment of a wide spectrum of bacterial infections. However, due to the versatility of bacteria many previously treatable species are developing resistance to the antibiotics currently available and so there is ever a need to develop more ~-lactam antibiotics, which are effective and yet safe. A major drawback to the ~-lactams is the degree of immunologically adverse reactions they induce. It was the aim of t
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McDonald, Valerie Alexandra. "Evaluating Immunotoxicity of Quaternary Ammonium Compounds." Thesis, Virginia Tech, 2017. http://hdl.handle.net/10919/79723.

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Alkyl dimethyl benzyl ammonium chloride (ADBAC) and didecyl dimethyl ammonium chloride (DDAC) are common quaternary ammonium compounds used as disinfectants in households, medical, and restaurant settings. They cause occupational skin and respiratory hazards in humans, and developmental and reproductive toxicity in mice. They also cause increased secretions of proinflammatory cytokines in cell lines and vaginal inflammation in porcine models; but have not been evaluated for developmental immunotoxicity. We assessed immunotoxicity in-vitro with J774A.1 murine macrophage cell line by analyzing c
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Maliji, Ghorban. "Immunotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat." Thesis, University of Bristol, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319022.

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McDonald, Jennifer C. Venables Barney J. "Bacterial challenge in Lumbricus terrestris a terrestrial invertebrate immunotoxicity model /." [Denton, Tex.] : University of North Texas, 2007. http://digital.library.unt.edu/permalink/meta-dc-3640.

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Baken, Kirsten Annika. "Immunotoxicogenomics gene expression profiling as a tool to study immunotoxicity /." [Maastricht] : Maastricht : Universitaire Pers Maastricht ; University Library, Universiteit Maastricht [host], 2007. http://arno.unimaas.nl/show.cgi?fid=9329.

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Rabideau, Christine L. "Pesticide Mixtures Induce Immunotoxicity: Potentiation of Apoptosis and Oxidative Stress." Thesis, Virginia Tech, 2001. http://hdl.handle.net/10919/34547.

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The three insecticides of interest were lindane (an organochlorine), malathion (an organophosphate) and piperonyl butoxide (PBO; a synergist). Based on minimum cytotoxicity (> LC25), the following concentrations were chosen for the pesticide mixture studies: 70μM lindane (Lind), 50μM malathion (Mal) and 55μM PBO. In the AlamarBlue cytotoxicity assay, individual pesticide and mixtures of malathion/PBO (MP) and malathion/lindane (ML) prompted cytotoxicity with varying intensities (Mal 18.8%, Lind 20.4%, PBO 23.5%, ML 53.6% and MP 64.9%). Cytopathological analysis revealed apoptotic feature
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Olgun, Selen. "Immunotoxicity of Pesticide Mixtures and the Role of Oxidative Stress." Diss., Virginia Tech, 1998. http://hdl.handle.net/10919/11114.

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The immunotoxic effects of multiple pesticide exposure were evaluated. C57BL/6 mouse thymocytes were exposed to lindane, malathion, and permethrin, either separately or in mixtures of two pesticides, in concentrations ranging from 37.5 uM to 1mM. These exposures caused both apoptotic and necrotic cell death in thymocytes as evaluated by 7-aminoactinomycin-D, Annexin-V/PI, and lactate dehydrogenase release assays. When cells were exposed to lindane+malathion, or lindane+permethrin, a significantly greater-than-additive cytotoxicity was observed. The pesticide exposure caused DNA ladder formatio
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McDonald, Jennifer C. "Bacterial Challenge in Lumbricus Terrestris: A Terrestrial Invertebrate Immunotoxicity Model." Thesis, University of North Texas, 2007. https://digital.library.unt.edu/ark:/67531/metadc3640/.

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A bacterial challenge assay was developed utilizing the earthworm, Lumbricus terrestris, in order to assess potential immunotoxic effects from exposure to specific polychlorinated biphenyl congeners. Earthworms were inoculated with Aeromonous hydrophila, establishing a 10-day LD50. In vitro assays for effects of PCBs on phagocytosis agreed with mammalian studies, demonstrating potent suppression of phagocytosis by the non-coplanar PCB congener 138 and no suppression by the coplanar congener 126. However, when the effects of the two PCB congeners were evaluated for suppression of resistance to
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Mohammadian, Gholamreza. "Immunotoxicity of Chromium Contaminated Soil in the Earthworm, Lumbricus Terrestris." Thesis, University of North Texas, 1993. https://digital.library.unt.edu/ark:/67531/metadc501250/.

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Objective was to assess the toxicity of chromium (Cr) contaminated soil (CS) using the earthworm Lumbricus terrestris. Specific aims were to determine: (1) survival (LC50); .(2) immunotoxicity as indicated by lysozyme activity, coelomocyte counts, secretory (SR) and erythrocyte rosette (ER) formation, and phagocytosis; and (3) compare effects of CS exposure with those of Cr spiked artificial soil (AS) . CS Cr concentration was 8.78 mg/g with 98.2% being Cr^3+ and 1.8% being Cr^6+. Using 14 d AS protocol the LC50 was 6.49% CS: AS mixture. CS concentrations of 0.5, 1.0, 2.5 and 5.0% were subleth
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Books on the topic "Immunotoxicity"

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Dietert, Rodney R., ed. Immunotoxicity Testing. Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-401-2.

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DeWitt, Jamie C., Cheryl E. Rockwell, and Christal C. Bowman, eds. Immunotoxicity Testing. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8549-4.

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Dayan, A. D., R. F. Hertel, E. Heseltine, G. Kazantzis, E. M. Smith, and M. T. Van der Venne, eds. Immunotoxicity of Metals and Immunotoxicology. Springer US, 1990. http://dx.doi.org/10.1007/978-1-4684-8443-4.

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D, Dayan Anthony, International Programme on Chemical Safety., Fraunhofer-Institut für Toxikologie und Aerosolforschung (Hannover, Germany), and Medizinische Hochschule Hannover, eds. Immunotoxicity of metals and immunotoxicology. Plenum Press, 1990.

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Dietert, Rodney R., and Robert W. Luebke, eds. Immunotoxicity, Immune Dysfunction, and Chronic Disease. Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-812-2.

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Programme, United Nations Environment, International Labour Organisation, World Health Organization, and International Program on Chemical Safety., eds. Principles and methods for assessing direct immunotoxicity associated with exposure to chemicals. World Health Organization, 1996.

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Immunotoxicity testing: Methods and protocols. Humana Press, 2010.

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Dietert, Rodney R. Immunotoxicity Testing: Methods and Protocols. Humana Press, 2016.

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DeWitt, Jamie C., Cheryl E. Rockwell, and Christal C. Bowman. Immunotoxicity Testing: Methods and Protocols. Springer New York, 2019.

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Dayan, Anthony D., R. F. Hertel, E. Heseltine, G. Kazantis, and E. B. Smith. Immunotoxicity of Metals and Immunotoxicology. Springer, 2012.

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Book chapters on the topic "Immunotoxicity"

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Nahler, Gerhard. "immunotoxicity." In Dictionary of Pharmaceutical Medicine. Springer Vienna, 2009. http://dx.doi.org/10.1007/978-3-211-89836-9_672.

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Hartung, Thomas. "Immunotoxicity." In Methods in Pharmacology and Toxicology. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0521-8_11.

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Brousseau, Pauline, and Michel Fournier. "Aquatic Immunotoxicity." In Encyclopedia of Aquatic Ecotoxicology. Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-007-5704-2_8.

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Exon, J. H., and L. D. Koller. "Immunotoxicity of Cadmium." In Handbook of Experimental Pharmacology. Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-70856-5_9.

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Petrarca, Claudia, Rocco Mangifesta, and Luca Di Giampaolo. "Immunotoxicity of Nanoparticles." In Current Topics in Environmental Health and Preventive Medicine. Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-4735-5_6.

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Salazar, Keith D., and Rosana Schafer. "Introduction to Immunotoxicity." In Molecular and Integrative Toxicology. Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-812-2_1.

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Taylor, Michael J. "Immunotoxicity of Trichothecene Mycotoxins." In Biodeterioration Research. Springer US, 1990. http://dx.doi.org/10.1007/978-1-4757-9453-3_6.

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Jeong, Tae Cheon. "Metabolism: Role in Immunotoxicity." In Encyclopedia of Immunotoxicology. Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-54596-2_970.

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Keil, Deborah E. "Immunotoxicity of Perfluoroalkylated Compounds." In Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-15518-0_10.

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Dietert, Rodney R., and Leigh Ann Burns-Naas. "Developmental Immunotoxicity in Rodents." In Immunotoxicology Strategies for Pharmaceutical Safety Assessment. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470386385.ch21.

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Conference papers on the topic "Immunotoxicity"

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Niu, Q., Q. Zhang, H. Li, L. Wang, and X. Lu. "1708b The immunotoxicity and neurotoxicity of aluminium." In 32nd Triennial Congress of the International Commission on Occupational Health (ICOH), Dublin, Ireland, 29th April to 4th May 2018. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/oemed-2018-icohabstracts.139.

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Herrmann, Delia, Guido Seitz, Steven W. Warmann, Michael Bonin, Jörg Fuchs, and Sorin Armeanu-Ebinger. "Abstract 3416: Cetuximab promotes immunotoxicity against rhabdomyosarcoma in vitro." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-3416.

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Zhernov, Yu V., A. O. Litovkina, I. V. Perminova, and M. R. Khaitov. "Immunotoxicity and allergenic properties of humic acids isolated from peloid." In Fifth International Conference of CIS IHSS on Humic Innovative Technologies «Humic substances and living systems». CLUB PRINT ltd., 2019. http://dx.doi.org/10.36291/hit.2019.zhernov.018.

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Ishihara, Jun, Aslan Mansurov, and Jeffrey Hubbell. "1227 Eliminating the immunotoxicity of interleukin-12 through protease-sensitive masking." In SITC 37th Annual Meeting (SITC 2022) Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/jitc-2022-sitc2022.1227.

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Zhuang, Yaohua, Peng Gao, Hangbing Cao, et al. "Methylglyoxal Potentiates AMPK-Mediated Polarization of M2d-Like Tumor-Associated Macrophages." In International Medicine and Health Sciences Congress. ECER, 2024. https://doi.org/10.53375/imhsc.2024.114.

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Methylglyoxal (MGO) is a widely-used compound in food industry, which is also produced by glycolytic metabolism. It is known to be associated with multiple chronic diseases, such as type 2 diabetes, cardiovascular diseases, and cancers. Although our immune system is actively removing mutated cells, recent findings indicated that tumor-associated macrophages (TAMs) could induce immunosuppression and promote cancer cell proliferation in tumor microenvironment, the polarization of which was regulated by cell metabolism. Since the MGO levels can be increased by the accelerated glycolysis in tumor
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Prado Prado, Francisco, Esvieta Tenorio Borroto, and Humberto González-Díaz. "Computational model for multiplex assay of drug immunotoxicity in macrophage - study of the anti-microbial G1 using flow cytometry." In The 17th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2013. http://dx.doi.org/10.3390/ecsoc-17-e001.

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Khalikova, K. F., G. R. Yamalova, N. N. Mishina, A. V. Malanev, R. M. Aslanov, and D. V. Aleev. "Experimental evaluation of the immunotoxic effect of a new muscle relaxant." In БИОТЕХНОЛОГИЯ: НАУЧНЫЕ ИССЛЕДОВАНИЯ И СВЯЗЬ С ПРОИЗВОДСТВОМ. Всероссийский научно-исследовательский и технологический институт биологической промышленности, 2024. https://doi.org/10.47804/978-5-89904-038-2-2024-276-279.

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Currently, the use of muscle relaxants is becoming important in the immobilization of animals in veterinary medicine. A new muscle relaxant with muscle relaxant properties has been synthesized by the staff of the Department of Toxicology of the Federal State Budgetary Budgetary Institution "FCTRB-VNIVI". The introduction of a new compound into veterinary practice usually occurs after a number of preclinical studies. One of the important parts of preclinical toxicological studies is the study of immunotoxicity, aimed at identifying possible negative effects of the drug on the immune system. Exp
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Young, Arabella, Vinh Nguyen, Jee Hye Kang, et al. "Abstract PR07: Developing syngeneic NOD tumor models to profile immunotoxicity and antitumor immunity in response to cancer immunotherapies in autoimmune-prone mice." In Abstracts: Fourth CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival; September 30 - October 3, 2018; New York, NY. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/2326-6074.cricimteatiaacr18-pr07.

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Verhaert, Marthe, and Sandrine Aspeslagh. "1272 Two-year experience of BITOX: the Belgian multidisciplinary ImmunoTOXicity board, a nationwide initiative of the Belgian Society for Medical Oncology (BSMO)." In SITC 38th Annual Meeting (SITC 2023) Abstracts. BMJ Publishing Group Ltd, 2023. http://dx.doi.org/10.1136/jitc-2023-sitc2023.1272.

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She, Yue, Zhong Wang, Nan Wang, and Yanfei Li. "Notice of Retraction: Effects of Aluminum on Intracellular Calcium Homeostasis of Splenic Lymphocytes in Chickens Cultured In Vitro: Preliminary Study of Aluminum Immunotoxicity in Chickens." In 2011 5th International Conference on Bioinformatics and Biomedical Engineering. IEEE, 2011. http://dx.doi.org/10.1109/icbbe.2011.5781428.

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Reports on the topic "Immunotoxicity"

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Riedel, J. A., and D. R. Mattie. Immunotoxicity of Jet Fuels and Solvents. Defense Technical Information Center, 2002. http://dx.doi.org/10.21236/ada453158.

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Kalinich, John F. Carcinogenicity and Immunotoxicity of Embedded Depleted Uranium and Heavy-Metal Tugsten Alloy in Rodents. Defense Technical Information Center, 2004. http://dx.doi.org/10.21236/ada428281.

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Kalinich, John F., ALexandra C. Miller, and David E. McClain. Carcinogenicity and Immunotoxicity of Embedded Depleted Uranium and Heavy-Metal Tungsten Alloy in Rodents. Defense Technical Information Center, 2006. http://dx.doi.org/10.21236/ada458449.

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Carlson, E. A., Y. Li, and J. T. Zelikoff. Inhibition of CYP1A-Mediated Metabolism of Benzo(A)Pyrene (BAP): Effects Upon BAP-Induced Immunotoxicity in Japanese Medaka (Oryzias Latipes). Defense Technical Information Center, 2001. http://dx.doi.org/10.21236/ada402076.

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Systemic and immunotoxicity induced by topical application of perfluorohexane sulfonic acid (PFHxS) in a murine model (dataset). U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 2024. http://dx.doi.org/10.26616/nioshrd-1089-2024-0.

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Systemic and immunotoxicity induced by topical application of perfluoroheptane sulfonic acid (PFHpS) or perfluorooctane sulfonic acid (PFOS) in a murine model (dataset). U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 2024. http://dx.doi.org/10.26616/nioshrd-1093-2024-0.

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NTP Immunotoxicity Technical Report on the Dermal Hypersensitivity and Irritancy Studies of 4-Methylcyclohexanemethanol (CASRN 34885-03-5) and Crude 4-Methylcyclohexanemethanol Administered Topically to Female BALB/c Mice. NIEHS, 2020. http://dx.doi.org/10.22427/ntp-imm-01.

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