Academic literature on the topic 'Inbred rat'

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Journal articles on the topic "Inbred rat"

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Thomas, Michael A., Chin-Fu Chen, Michael I. Jensen-Seaman, Peter J. Tonellato, and Simon N. Twigger. "Phylogenetics of rat inbred strains." Mammalian Genome 14, no. 1 (2003): 61–64. http://dx.doi.org/10.1007/s00335-002-2204-5.

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Kuramoto, Takashi, Satoshi Nakanishi, and Tadao Serikawa. "Functional polymorphisms in inbred rat strains and their allele frequencies in commercially available outbred stocks." Physiological Genomics 33, no. 2 (2008): 205–11. http://dx.doi.org/10.1152/physiolgenomics.00222.2007.

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Polymorphisms that have been proven to influence gene functions are called functional polymorphisms. It is significant to know the distribution of functional polymorphisms in the rat, widely used in animal models for human diseases. In this study, we assessed 16 functional polymorphisms consisting of 3 coat color and 13 disease-associated genes in 136 rat strains, as a part of the genetic profiling program of the National Bio Resource Project for the Rat (NBRP-Rat). Polymorphisms of Cdkn1a, Fcgr3, Grp10, Lss, and Fdft1, which were proven to function in prostate tumorigenesis, glomerulonephriti
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Kren, V., T. W. Kurtz, D. Krenova, V. Bila, M. Printz, and P. Pravenec. "Rat genome mapping using recombinant inbred strains." Transplantation Proceedings 29, no. 3 (1997): 1768. http://dx.doi.org/10.1016/s0041-1345(97)00048-1.

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Schlick, Nancy E., Michael I. Jensen-Seaman, Kimberly Orlebeke, Anne E. Kwitek, Howard J. Jacob, and Jozef Lazar. "Sequence analysis of the complete mitochondrial DNA in 10 commonly used inbred rat strains." American Journal of Physiology-Cell Physiology 291, no. 6 (2006): C1183—C1192. http://dx.doi.org/10.1152/ajpcell.00234.2006.

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Rat remains a major biomedical model system for common, complex diseases. The rat continues to gain importance as a model system with the completion of its full genomic sequence. Although the genomic sequence has generated much interest, only three complete sequences of the rat mitochondria exist. Therefore, to increase the knowledge of the rat genome, the entire mitochondrial genomes (16,307–16,315 bp) from 10 inbred rat strains (that are standard laboratory models around the world) and 2 wild rat strains were sequenced. We observed a total of 195 polymorphisms, 32 of which created an amino a
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Pohlová, Irena, Josef Zicha, Vladimir Křen, Jaroslav Kuneš, and Michal Pravenec. "Renal renin activity is associated with alterations of the renin gene in recombinant inbred rat strains." Clinical Science 84, no. 2 (1993): 129–32. http://dx.doi.org/10.1042/cs0840129.

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1. A structural alteration within the first intron of the renin gene in spontaneously hypertensive rats was demonstrated to co-segregate with blood pressure in some sets of F2 hybrids or recombinant inbred strains. There is no evidence as to whether restriction fragment length polymorphism of the renin gene is associated with any of the changes in the renin tissue level. For this reason we have determined renal renin activity in spontaneously hypertensive, Wistar-Kyoto and Brown Norway rats as well as in 22 recombinant inbred strains derived from F2 hybrids of spontaneously hypertensive and Br
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Bell, R. G. "Variation in responsiveness toTrichinella spiralisinfection in inbred rat strains." Parasitology 105, no. 1 (1992): 125–30. http://dx.doi.org/10.1017/s0031182000073777.

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An analysis of interstrain variation between 12 inbred and 4 congenic rat strains in the expression of immunity againstTrichinella spiralisis reported. All rat strains expressed strong rapid expulsion which resulted in the elimination of 88–98% of a challenge infection of muscle larvae. In contrast, substantial interstrain variation in the rate of adult worm expulsion in the primary infection as evident. By day 10 after infection, BUF and YO strains had < 50 worms left in the intestine whereas BI and WKA strain rats had barely begun rejection, with approximately 1000 worms present in the gu
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Woo, Lynn L., Adonis Hijaz, Hui Q. Pan, Mei Kuang, Raymond R. Rackley, and Margot S. Damaser. "Simulated childbirth injuries in an inbred rat strain." Neurourology and Urodynamics 28, no. 4 (2009): 356–61. http://dx.doi.org/10.1002/nau.20644.

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Sprott, R. L., and I. Ramirez. "Current Inbred and Hybrid Rat and Mouse Models." ILAR Journal 38, no. 3 (1997): 104–9. http://dx.doi.org/10.1093/ilar.38.3.104.

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Leyten, R., J. P. A. M. Vroemen, N. Blanckaert, and K. P. M. Heirwegh. "The congenic normal R/APfd and jaundiced R/APfd-j/j rat strains: a new animal model of hereditary non-haemolytic unconjugated hyperbilirubinaemia due to defective bilirubin conjugation." Laboratory Animals 20, no. 4 (1986): 335–42. http://dx.doi.org/10.1258/002367786780808758.

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In this paper the production of the R/APfd-j/j strain which is congenic with the R/APfd strain is reported. The R/APfd-j/j completely lacks hepatic bilirubin UDP-glucuronyltransferase activity, as do our GUNNXR/Pfd-j/j rat strain and various other stocks of GUNN rats (j/j) described in the literature. Our recombinant inbred strain GUNNXR/Pfd-j/j was produced from non-inbred GUNN (j/j) rats. This GUNNXR/Pfd-j/j rat was used as a donor of the jaundice gene j, the R/APfd rat serving as the recipient. After eight backcross-intercross cycles (16 generations) the R/APfd-j/j strain was obtained which
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Power, D. A., C. Cunningham, and G. R. D. Catto. "The role of RT1 antigen differences in semi-allogeneic rat pregnancy." Clinical Science 72, no. 1 (1987): 37–45. http://dx.doi.org/10.1042/cs0720037.

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1. The immunological mechanisms involved in sustaining normal semi-allogeneic pregnancies and in the enhancement of organ allografts were investigated in inbred rats. 2. The antigenic targets for alloantibodies formed after leucocyte transfusions and multiple allogeneic pregnancies were defined by the EA rosette inhibition (EAI) assay in several congenic and recombinant inbred rat strains. 3. Alloantibodies produced by leucocyte immunization (conventionally induced antisera) were directed only to RT1-encoded (major histocompatibility complex, MHC) antigens. Both RT1A (class I MHC) and either R
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Dissertations / Theses on the topic "Inbred rat"

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Grieve, Ian C. "Quantitative trait analysis in a panel of recombinant inbred rat strains." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/5617.

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Expression quantitative trait loci (eQTLs) are generated by the combined use of microarray technology to measure gene expression and genetic linkage analysis to map the expression traits to the genome. This thesis describes co-expression and quantitative trait transcript (QTT) analysis carried out on a dataset consisting of thousands of cis- and trans-eQTLs. These were mapped in 29 rat Recombinant Inbred strains derived from a cross between the Spontaneously Hypertensive Rat (SHR), a widely used model of the human metabolic syndrome, and the normotensive Brown Norway (BN). Gene expression data
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Ghosh, Sumona. "Effect of exercise training on metabolic intermediate phenotypes in inbred rat strains." Connect to Online Resource-OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=mco1182807006.

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Thesis (M.S.)--University of Toledo, 2007.<br>"In partial fulfillment of the requirements for the degree of Master of Science in Biomedical Sciences." Title from title page of PDF document. Bibliography: p. 59-68.
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Ghosh, Sumona. "Effects of Exercise Training on Metabolic Intermediate Phenotypes in Inbred Rat Strains." University of Toledo Health Science Campus / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=mco1182807006.

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Garrett, Michael R. "Genetic dissection of hypertension-related renal disease using the Dahl salt-sensitive rat." Connect to Online Resource-OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=mco1175545256.

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Dissertation (Ph.D.)--University of Toledo, 2006.<br>"In partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biomedical Sciences." Title from title page of PDF document. Bibliography: p. 89-95, p. 127-131, p. 184-192, p.198-233.
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Ways, Justin Andrew. "An Inbred Rat Model of Exercise Capacity: The Path to Identifying Alleles Regulating Variation in Treadmill Running Performance and Associated Phenotypes." Connect to full text in OhioLINK ETD Center, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=mco1201562803.

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Dissertation (Ph.D.)--University of Toledo, 2007.<br>"In partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biomedical Sciences." Title from title page of PDF document. Bibliography: p. 142-183.
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Baker, K. C. "The absorption from the gut and immunomodulatory effects of the sulphated polygalactan food-additive, carrageenan : Studies in the inbred rat." Thesis, University of Reading, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371432.

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Bossy, Tanya. "Implication of a novel nerve growth factor (NGF) maturation and degradation cascade in the Fischer-344 rat model of age-associated memory deficits." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111573.

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Despite the overwhelming evidence for atrophy of the NGF-dependant Basal Forebrain Cholinergic neurons during aging, there is no persuasive evidence towards a decrease in NGF and/or NGF mRNA content in the brain of aged animals. Previous experiments from our laboratory have shown that NGF is released as a precursor protein and cleaved into the mature form in the extracellular space under the influence of a complex protease cascade. These recent findings have lead us to propose that any alterations in levels and/or activity of this maturation/degradation cascade might affect NGF's biological ac
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Todd, Derrick James. "Role of the Intestinal Immune System in the Pathogenesis of Autoimmune Diabetes in the BB Rat Model of Type 1 Diabetes Mellitus." eScholarship@UMMS, 2001. https://escholarship.umassmed.edu/gsbs_diss/138.

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The intestine is the largest lymphoid organ in the body, challenged constantly by an enonnous quantity and diversity of antigens. Distinct from peripheral lymphocytes, intestinal lymphocytes have evolved unique mechanisms of tolerance and appear to govern mucosal processes such as "chronic physiologic inflammation" and oral tolerance. Failure of mucosal tolerance has been implicated in the pathogenesis of several diseases, including inflammatory bowel disease, celiac disease, and even autoimmune diabetes. One population of intestinal lymphocytes, intraepithelial lymphocytes (IELs), exists with
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van, Wijngaarden Peter, and petervanwijn@yahoo com au. "Heritable influences in oxygen-induced retinopathy." Flinders University. Medicine, 2006. http://catalogue.flinders.edu.au./local/adt/public/adt-SFU20060824.211102.

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Retinopathy of prematurity, a disease characterised by aberrant retinal vascular development in premature neonates, is a leading cause of blindness and visual impairment in childhood. This work sought to examine differences in the susceptibility of inbred rat strains to oxygen-induced retinopathy, a model of human retinopathy of prematurity. The overriding aim was to identify genetic factors in rats that might be generalisable to humans. Newborn rats of six different strains were exposed to alternating cycles of hyperoxia and relative hypoxia for fourteen days. Rats were removed to room air
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Sweeney, Patricia M. "Indirect inbred selection for drying rate in maize hybrids /." The Ohio State University, 1990. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487681788253123.

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Books on the topic "Inbred rat"

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Neurobiology of reproduction in the female rat: A fifty-year perspective. Springer-Verlag, 1989.

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L, Snyder David, ed. Dietary restriction and aging: Proceedings of the Symposium on the Effects of Dietary Restriction on Aging and Disease in Germfree and Conventional Lobund-Wistar Rats, held in Notre Dame, Indiana, March 27-29, 1988. A.R. Liss, 1989.

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A, Boorman Gary, ed. Pathology of the Fischer rat: Reference and atlas. Academic Press, 1990.

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Boorman, Gary A., Scot L. Eustis, Michael R. Elwell, and C. Montgomery. Pathology of the Fischer Rat: Reference and Atlas. Academic Press, 1990.

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Boorman, Gary A., Scot L. Eustis, Michael R. Elwell, and C. Montgomery. Pathology of the Fischer Rat: Reference and Atlas. Academic Press, 1990.

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Everett, Jack W. Neurobiology of Reproduction in the Female Rat: A 50 Year Perspective (Monographs on Endocrinology). Springer, 1990.

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Kenji, Shima, ed. Obesity and NIDDM: Lessons from the OLETF rat. Elsevieer, 1999.

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J, Hedrich Hans, Adams M, and International Council for Laboratory Animal Science., eds. Genetic monitoring of inbred strains of rats: A manual on colony management, basic monitoring techniques, and genetic variants of the laboratory rat. Gustav Fischer Verlag, 1990.

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Hedrich, Hans J. Genetic Monitoring of Inbred Strains of Rats: A Manual on Colony Management, Basic Monitoring Techniques, and Genetic Variants of the Laboratory Rat. Gustav Fischer, 1991.

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Festing, Michael F. W. Inbred Strains in Biomedical Research. Palgrave, 2014.

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Book chapters on the topic "Inbred rat"

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Okuyama, Tohru, Kazuo Hashi, Yasutaka Kurokawa, Satoshi Sasaki, and Katsuko Sudo. "Morphological Study on Congenital Hydrocephalus of the Inbred Rat, LEW/Jms." In Annual Review of Hydrocephalus. Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-662-11155-0_6.

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Karlsson, Sandra, and Karin Klinga-Levan. "Expression Analysis of Human Endometrial Adenocarcinoma in an Inbred Rat Model." In Hormonal Carcinogenesis V. Springer New York, 2008. http://dx.doi.org/10.1007/978-0-387-69080-3_50.

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Yankah, A. C., and H.-U. Wottge. "Immunosuppression in allograft valve surgery. A study on inbred rat model." In Cardiac Valve Allografts. Steinkopff, 1997. http://dx.doi.org/10.1007/978-3-642-59250-8_14.

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Gasser, M., W. Timmermann, and A. Thiede. "Segmental Femoral Artery Allografts: Histomorphological Analysis of the Rejection Response in Inbred Rat Strains." In Organtransplantation in Rats and Mice. Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-72140-3_36.

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Timmermann, W., and A. Thiede. "The Rejection Response to Segmental Grafts of the Femoral Artery in Inbred Rat Strains." In Microsurgical Models in Rats for Transplantation Research. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-61657-0_16.

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Okuyama, Tohru, Kazuo Hashi, Satoshi Sasaki, Katsuko Sudo, and Yasutaka Kurokawa. "Changes in Cerebral Microvasculature in Congenital Hydrocephalus of the Inbred Rat LEW/Jms: Light and electron microscopic examination." In Annual Review of Hydrocephalus. Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-662-11152-9_3.

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Yamada, Hiroshi, Norihiko Tamaki, Takayuki Shirakuni, et al. "The Etiology of the Congenital Hydrocephalus in the Inbred Rat LEW/Jms: Light microscopic study in the embryonic stage." In Annual Review of Hydrocephalus. Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-662-11155-0_2.

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Engemann, R., H. J. Gassel, Th Schang, A. Thiede, and H. Hamelmann. "The Immunogenicity of Isolated Liver Cells: Comparison of Complete Liver Cell Suspensions (LCS) versus Liver Parenchymal Cell Suspensions (LPS) in Two Different Allogeneic Inbred Rat Strain Combinations." In Experimental and Clinical Hepatology. Springer Netherlands, 1986. http://dx.doi.org/10.1007/978-94-009-4151-9_22.

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Scheidel, P. H., M. Korell, T. Strowitzki, U. Noss, R. A. Wiedemann, and H. K. Hepp. "Orthotopic Transplantation of the Fallopian Tube, Ovary, and Segment of the Uterus in Inbred Rats." In Microsurgical Models in Rats for Transplantation Research. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-61657-0_51.

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Gugenheim, J., D. Houssin, E. Martin, and H. Bismuth. "Decreased Graft Versus Host Reaction After Portal Venous Drainage of Spleen Grafts in Inbred Strains of Rats." In Microsurgical Models in Rats for Transplantation Research. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-61657-0_45.

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Conference papers on the topic "Inbred rat"

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Jo, T., K. Tsuchiya, M. Hassan, S. Siddiqui, H. Ghezzo, and JG Martin. "Investigation of Molecular Regulation in the Airways of Two Highly Inbred Rat Strains." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a6042.

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