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Journal articles on the topic 'Inbred rat'

Author: Grafiati

Published: 4 June 2021

Last updated: 5 February 2022

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1

Thomas, Michael A., Chin-Fu Chen, Michael I. Jensen-Seaman, Peter J. Tonellato, and Simon N. Twigger. "Phylogenetics of rat inbred strains." Mammalian Genome 14, no. 1 (2003): 61–64. http://dx.doi.org/10.1007/s00335-002-2204-5.

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2

Kuramoto, Takashi, Satoshi Nakanishi, and Tadao Serikawa. "Functional polymorphisms in inbred rat strains and their allele frequencies in commercially available outbred stocks." Physiological Genomics 33, no. 2 (2008): 205–11. http://dx.doi.org/10.1152/physiolgenomics.00222.2007.

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Polymorphisms that have been proven to influence gene functions are called functional polymorphisms. It is significant to know the distribution of functional polymorphisms in the rat, widely used in animal models for human diseases. In this study, we assessed 16 functional polymorphisms consisting of 3 coat color and 13 disease-associated genes in 136 rat strains, as a part of the genetic profiling program of the National Bio Resource Project for the Rat (NBRP-Rat). Polymorphisms of Cdkn1a, Fcgr3, Grp10, Lss, and Fdft1, which were proven to function in prostate tumorigenesis, glomerulonephriti

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3

Kren, V., T. W. Kurtz, D. Krenova, V. Bila, M. Printz, and P. Pravenec. "Rat genome mapping using recombinant inbred strains." Transplantation Proceedings 29, no. 3 (1997): 1768. http://dx.doi.org/10.1016/s0041-1345(97)00048-1.

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4

Schlick, Nancy E., Michael I. Jensen-Seaman, Kimberly Orlebeke, Anne E. Kwitek, Howard J. Jacob, and Jozef Lazar. "Sequence analysis of the complete mitochondrial DNA in 10 commonly used inbred rat strains." American Journal of Physiology-Cell Physiology 291, no. 6 (2006): C1183—C1192. http://dx.doi.org/10.1152/ajpcell.00234.2006.

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Rat remains a major biomedical model system for common, complex diseases. The rat continues to gain importance as a model system with the completion of its full genomic sequence. Although the genomic sequence has generated much interest, only three complete sequences of the rat mitochondria exist. Therefore, to increase the knowledge of the rat genome, the entire mitochondrial genomes (16,307–16,315 bp) from 10 inbred rat strains (that are standard laboratory models around the world) and 2 wild rat strains were sequenced. We observed a total of 195 polymorphisms, 32 of which created an amino a

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5

Pohlová, Irena, Josef Zicha, Vladimir Křen, Jaroslav Kuneš, and Michal Pravenec. "Renal renin activity is associated with alterations of the renin gene in recombinant inbred rat strains." Clinical Science 84, no. 2 (1993): 129–32. http://dx.doi.org/10.1042/cs0840129.

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1. A structural alteration within the first intron of the renin gene in spontaneously hypertensive rats was demonstrated to co-segregate with blood pressure in some sets of F2 hybrids or recombinant inbred strains. There is no evidence as to whether restriction fragment length polymorphism of the renin gene is associated with any of the changes in the renin tissue level. For this reason we have determined renal renin activity in spontaneously hypertensive, Wistar-Kyoto and Brown Norway rats as well as in 22 recombinant inbred strains derived from F2 hybrids of spontaneously hypertensive and Br

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6

Bell, R. G. "Variation in responsiveness toTrichinella spiralisinfection in inbred rat strains." Parasitology 105, no. 1 (1992): 125–30. http://dx.doi.org/10.1017/s0031182000073777.

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An analysis of interstrain variation between 12 inbred and 4 congenic rat strains in the expression of immunity againstTrichinella spiralisis reported. All rat strains expressed strong rapid expulsion which resulted in the elimination of 88–98% of a challenge infection of muscle larvae. In contrast, substantial interstrain variation in the rate of adult worm expulsion in the primary infection as evident. By day 10 after infection, BUF and YO strains had < 50 worms left in the intestine whereas BI and WKA strain rats had barely begun rejection, with approximately 1000 worms present in the gu

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7

Woo, Lynn L., Adonis Hijaz, Hui Q. Pan, Mei Kuang, Raymond R. Rackley, and Margot S. Damaser. "Simulated childbirth injuries in an inbred rat strain." Neurourology and Urodynamics 28, no. 4 (2009): 356–61. http://dx.doi.org/10.1002/nau.20644.

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8

Sprott, R. L., and I. Ramirez. "Current Inbred and Hybrid Rat and Mouse Models." ILAR Journal 38, no. 3 (1997): 104–9. http://dx.doi.org/10.1093/ilar.38.3.104.

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9

Leyten, R., J. P. A. M. Vroemen, N. Blanckaert, and K. P. M. Heirwegh. "The congenic normal R/APfd and jaundiced R/APfd-j/j rat strains: a new animal model of hereditary non-haemolytic unconjugated hyperbilirubinaemia due to defective bilirubin conjugation." Laboratory Animals 20, no. 4 (1986): 335–42. http://dx.doi.org/10.1258/002367786780808758.

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In this paper the production of the R/APfd-j/j strain which is congenic with the R/APfd strain is reported. The R/APfd-j/j completely lacks hepatic bilirubin UDP-glucuronyltransferase activity, as do our GUNNXR/Pfd-j/j rat strain and various other stocks of GUNN rats (j/j) described in the literature. Our recombinant inbred strain GUNNXR/Pfd-j/j was produced from non-inbred GUNN (j/j) rats. This GUNNXR/Pfd-j/j rat was used as a donor of the jaundice gene j, the R/APfd rat serving as the recipient. After eight backcross-intercross cycles (16 generations) the R/APfd-j/j strain was obtained which

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10

Power, D. A., C. Cunningham, and G. R. D. Catto. "The role of RT1 antigen differences in semi-allogeneic rat pregnancy." Clinical Science 72, no. 1 (1987): 37–45. http://dx.doi.org/10.1042/cs0720037.

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1. The immunological mechanisms involved in sustaining normal semi-allogeneic pregnancies and in the enhancement of organ allografts were investigated in inbred rats. 2. The antigenic targets for alloantibodies formed after leucocyte transfusions and multiple allogeneic pregnancies were defined by the EA rosette inhibition (EAI) assay in several congenic and recombinant inbred rat strains. 3. Alloantibodies produced by leucocyte immunization (conventionally induced antisera) were directed only to RT1-encoded (major histocompatibility complex, MHC) antigens. Both RT1A (class I MHC) and either R

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11

Wang, C. G., J. J. Almirall, C. S. Dolman, R. J. Dandurand, and D. H. Eidelman. "In vitro bronchial responsiveness in two highly inbred rat strains." Journal of Applied Physiology 82, no. 5 (1997): 1445–52. http://dx.doi.org/10.1152/jappl.1997.82.5.1445.

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Wang, C. G., J. J. Almirall, C. S. Dolman, R. J. Dandurand, and D. H. Eidelman. In vitro bronchial responsiveness in two highly inbred rat strains. J. Appl. Physiol. 82(5): 1445–1452, 1997.—We investigated methacholine (MCh)-induced bronchoconstriction in explanted airways from Fischer and Lewis rats. Lung explants, 0.5- to 1.0-mm thick, were prepared from agarose-inflated lungs of anesthetized 8- to 12-wk-old male rats. After overnight culture, videomicroscopy was used to record baseline images of the individual airways. Dose-response curves to MCh were then constructed by repeated administra

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12

Behmoaras, Jacques, Mary Osborne-Pellegrin, Dominique Gauguier, and Marie-Paule Jacob. "Characteristics of the aortic elastic network and related phenotypes in seven inbred rat strains." American Journal of Physiology-Heart and Circulatory Physiology 288, no. 2 (2005): H769—H777. http://dx.doi.org/10.1152/ajpheart.00544.2004.

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Extracellular matrix (ECM) molecules such as elastin and collagen provide mechanical support to the vessel wall and are essential for vascular function. Evidence that genetic factors influence aortic ECM composition and organization was concluded from our previous studies showing that the inbred Brown Norway (BN) rat differs significantly from the outbred Long-Evans (LE) and the inbred LOU rat with respect to both thoracic aortic elastin content and internal elastic lamina (IEL) rupture in the abdominal aorta and iliac arteries. Here, we measured aortic elastin and collagen contents as well as

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13

KOCH, LAUREN GERARD, STEVEN L. BRITTON, JOHN C. BARBATO, DAVID W. RODENBAUGH, and STEPHEN E. DiCARLO. "Phenotypic differences in cardiovascular regulation in inbred rat models of aerobic capacity." Physiological Genomics 1, no. 2 (1999): 63–69. http://dx.doi.org/10.1152/physiolgenomics.1999.1.2.63.

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Koch, Lauren Gerard, Steven L. Britton, John C. Barbato, David W. Rodenbaugh, and Stephen E. DiCarlo. Phenotypic differences in cardiovascular regulation in inbred rat models of aerobic capacity. Physiol. Genomics 63–69, 1999.—The Dark Aouti (DA) inbred strain of rats has superior aerobic treadmill running capacity compared with the Copenhagen (COP) strain of inbred rats. This difference in aerobic capacity provides a model to explore the genetic basis of variation in this trait. The present study evaluated intermediate phenotypic differences between 10 male COP inbred rats and 10 male DA inbr

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14

Ibrahim, Jamila, Jody K. Miyashiro, and Bradford C. Berk. "Shear Stress Is Differentially Regulated Among Inbred Rat Strains." Circulation Research 92, no. 9 (2003): 1001–9. http://dx.doi.org/10.1161/01.res.0000069687.54486.b1.

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15

Rosenwasser, A. M., M. W. Pellowski, and E. D. Hendley. "Circadian timekeeping in hyperactive and hypertensive inbred rat strains." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 271, no. 3 (1996): R787—R796. http://dx.doi.org/10.1152/ajpregu.1996.271.3.r787.

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Inbred strains have been used to study genetic and physiological relationships among different aspects of circadian timekeeping, as well as relationships between circadian rhythmicity and other strain-specific traits. The present study characterized several features of circadian timekeeping in genetically hyperactive (WKHA) and genetically hypertensive (WKHT) inbred strains, derived from spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats. WKHAs and WKHTs differed in free-running period, steady-state entrainment to light-dark cycles, and photic phase shifting, and relationships among

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16

ERICKSON, C., and K. BYERS. "Sustained nicotine release comparisons in six inbred rat strains." Pharmacology Biochemistry and Behavior 33, no. 1 (1989): 63–67. http://dx.doi.org/10.1016/0091-3057(89)90430-9.

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17

Zhang-James, Yanli, Li Yang, Frank A. Middleton, Lina Yang, Jameson Patak, and Stephen V. Faraone. "Autism-related behavioral phenotypes in an inbred rat substrain." Behavioural Brain Research 269 (August 2014): 103–14. http://dx.doi.org/10.1016/j.bbr.2014.04.035.

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18

Michalkiewicz, Mieczyslaw, Teresa Michalkiewicz, Aron M. Geurts, et al. "Efficient transgenic rat production by a lentiviral vector." American Journal of Physiology-Heart and Circulatory Physiology 293, no. 1 (2007): H881—H894. http://dx.doi.org/10.1152/ajpheart.00060.2007.

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A lentiviral construct for an enhanced green fluorescent protein (eGFP) driven by a chicken β-actin promoter, cytomegalovirus enhancer, and intronic sequences from rabbit β-globin (CAG) was used to produce transgenic lines of rats for evaluation of the usefulness of this approach in gene function studies. Fertilized eggs were collected from inbred Dahl S and outbred Sprague-Dawley rats, and ∼100 pl of concentrated virus were microinjected into the perivitrelline space of one-cell embryos. Of 121 embryos injected, 60 pups (49.6%) were born. Transgenic rates averaged 22% in Dahl S and 14% in Spr

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19

Alemayehu, Adamu, Laura Breen, and Morton P. Printz. "A new inbred Wistar-Kyoto rat substrain exhibiting apparent salt sensitivity and borderline hypertension." American Journal of Physiology-Heart and Circulatory Physiology 283, no. 3 (2002): H1181—H1190. http://dx.doi.org/10.1152/ajpheart.00187.2002.

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The normotensive Wistar-Kyoto (WKY) rat strain is a traditional control for the spontaneously hypertensive rat (SHR). We found trait differences between two inbred normotensive WKY strains, derived originally from different vendors, and compared these two strains from La Jolla-Taconic Farms (WKY/lj-tf) and La Jolla-Charles River (WKY/lj-cr) with the inbred SHR/lj-cr for cardiovascular, diurnal, and activity traits under normal and high (8%) NaCl diets. Marked genetic diversity was found between the two vendor-derived WKY. By using an extended study design and radiotelemetry, we compared WKY/lj

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20

Cuenya, Lucas, Marta Sabariego, Rocío Donaire, Albert Fernández-Teruel, Carmen Torres, and Mauricio R. Papini. "Transfer across reward devaluation tasks in inbred Roman rat strains." Learning and Motivation 52 (November 2015): 22–31. http://dx.doi.org/10.1016/j.lmot.2015.08.003.

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21

Abbott, R. E., and D. Schachter. "Inheritance of salt-dependent hypertension in the inbred Dahl rat." Hypertension 24, no. 4 (1994): 506–11. http://dx.doi.org/10.1161/01.hyp.24.4.506.

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22

Bökenkamp, Regina, Adriana C. Gittenberger-De Groot, Conny J. Van Munsteren, Robert W. Grauss, Jaap Ottenkamp, and Marco C. Deruiter. "Persistent Ductus Arteriosus in the Brown-Norway Inbred Rat Strain." Pediatric Research 60, no. 4 (2006): 407–12. http://dx.doi.org/10.1203/01.pdr.0000238243.37116.a6.

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23

Biesiadecki, Brandon J., Paul H. Brand, Lauren G. Koch, Patricia J. Metting, and Steven L. Britton. "Phenotypic variation in sensorimotor performance among eleven inbred rat strains." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 276, no. 5 (1999): R1383—R1389. http://dx.doi.org/10.1152/ajpregu.1999.276.5.r1383.

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As a first step toward identifying the genes that determine sensorimotor ability (motor coordination) we subjected 11 inbred strains of rats to three different tests for this trait. Rats were tested at 13 wk of age to determine how long they could remain on 1) a rotating cylinder as the velocity of rotation increased every 5 s (1-direction rotation test), 2) a rotating cylinder that reversed direction every 5 s and increased velocity every 10 s (2-direction rotation test), and 3) a platform that was tilted 2° every 5 s from 22 to 47° (tilt test). On all three tests, rats of the PVG strain demo

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24

Basset, Alexandra, Dominique Laude, Stéphane Laurent, and Jean-Luc Elghozi. "Contrasting circadian rhythms of blood pressure among inbred rat strains." Journal of Hypertension 22, no. 4 (2004): 727–37. http://dx.doi.org/10.1097/00004872-200404000-00015.

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25

Yahata, T., T. Nagashima, M. Moriya, A. Kuroshima, F. Furuyama, and H. Nishino. "Improved cold-tolerance of the inbred heat-tolerant FOK rat." Pathophysiology 1 (November 1994): 215. http://dx.doi.org/10.1016/0928-4680(94)90447-2.

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26

Stanojević, Stanislava, Katarina Mitić, Vesna Vujić, Vesna Kovačević-Jovanović та Mirjana Dimitrijević. "β-endorphin differentially affects inflammation in two inbred rat strains". European Journal of Pharmacology 549, № 1-3 (2006): 157–65. http://dx.doi.org/10.1016/j.ejphar.2006.08.012.

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27

Sun, Q., and C. H. Turner. "Two Inbred Rat Strains That Differ Substantially in Hip Fragility." Calcified Tissue International 72, no. 4 (2003): 498–504. http://dx.doi.org/10.1007/s00223-002-1040-7.

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28

Woon, Peng Y., Anne M. Curtis, Pamela J. Kaisaki, et al. "Genomic organization of the rat Clock gene and sequence analysis in inbred rat strains." Genomics 87, no. 2 (2006): 208–17. http://dx.doi.org/10.1016/j.ygeno.2005.10.006.

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29

Rose, Rajiv, Bijan S. Kheirabadi, and Harold G. Klemcke. "Arterial blood gases, electrolytes, and metabolic indices associated with hemorrhagic shock: inter- and intrainbred rat strain variation." Journal of Applied Physiology 114, no. 9 (2013): 1165–73. http://dx.doi.org/10.1152/japplphysiol.01293.2012.

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We have previously shown interstrain variation (indicating a genetic basis), and intrastrain variation in survival time after hemorrhage (STaH) among inbred rat strains. To assist in understanding physiological mechanisms associated with STaH, we analyzed various arterial blood measures (ABM; pH, Paco2, oxygen content, sodium, potassium, glucose, bicarbonate, base excess, total CO2, and ionized calcium) in inbred rats. Rats from five inbred strains ( n = 8–10/strain) were catheterized and, ∼24 h later, subjected to a conscious, controlled, 47% hemorrhage. ABM were measured at the start (initia

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30

Avsaroglu, H., A. S. van der Sar, H. A. van Lith, L. F. M. van Zutphen, and L. J. Hellebrekers. "Differences in response to anaesthetics and analgesics between inbred rat strains." Laboratory Animals 41, no. 3 (2007): 337–44. http://dx.doi.org/10.1258/002367707781282811.

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Differences in response to analgesic and anaesthetic drugs can partly be attributed to variations in the genetic background of experimental animals. This study was carried out to determine differences in the response of inbred rat strains to a selection of analgesics and drugs used in anaesthetic protocols. A cross between the most contrasting strains can then be phenotyped in future studies in order to localize quantitative trait loci (QTLs) involved in analgesic/anaesthetic drug sensitivity. Eight inbred strains ( n = 6 rats/strain) were selected for the study: the pigmented ACI, BN and COP

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31

Waner, T., and A. Nyska. "Thyroxine (T4) and triiodothyronine (T3) levels in the Fischer 344 inbred rat." Laboratory Animals 22, no. 3 (1988): 276–80. http://dx.doi.org/10.1258/002367788780746458.

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Plasma levels of T3 and T4 were measured in male and female Fischer 344 (F344/Cr1) inbred rats aged 10, 17, 30, 56, 80 and 106 weeks in order to document the hormone profile of this strain of rat. In general, levels of T4 were higher in males than in females. Levels of T3 were lower in females for the first 17 weeks, similar for rats of age 30 weeks, and thereafter higher in the females than the males. T4 concentration decline was age-associated in both sexes. T3 levels declined in the males only, but remained relatively constant in the females throughout their lifespan. Generally, T4/T3 ratio

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32

Furuyama, F., and K. Ohara. "Genetic development of an inbred rat strain with increased resistance adaptation to a hot environment." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 265, no. 4 (1993): R957—R962. http://dx.doi.org/10.1152/ajpregu.1993.265.4.r957.

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The purpose of this study was to demonstrate resistance adaptation based on genotypic adaptation and to develop an inbred rat strain with genotypic resistance adaptation to a hot environment. Survival time (ST) at an ambient temperature (Ta) of 42.5 degrees C was determined without appreciable thermal damage. Rats with the longest ST were sibmated over 30 generations and designated FOK. The ST, evaporative water loss, and body water economy increased rapidly during the first 10-15 generations, followed by a more gradual increase. The FOK rat resisted a Ta of 42.5 degrees C for > 5 h; this a

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33

Klemcke, Harold G., Robert M. DeKroon, Mihaela Mocanu, Jennifer B. Robinette, and Oscar Alzate. "Cardiac mitochondrial proteomic expression in inbred rat strains divergent in survival time after hemorrhage." Physiological Genomics 45, no. 7 (2013): 243–55. http://dx.doi.org/10.1152/physiolgenomics.00118.2012.

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We have previously identified inbred rat strains differing in survival time to a severe controlled hemorrhage (StaH). In efforts to identify cellular mechanisms and ultimately genes that are important contributors to enhanced STaH, we conducted a study to characterize potential differences in cardiac mitochondrial proteins in these rats. Inbred rats from three strains [Brown Norway/Medical College of Wisconsin (BN); Dark Agouti (DA), and Fawn Hooded Hypertensive (FHH)] with different StaH (DA = FHH > BN) were assigned to one of three treatment groups ( n = 4/strain): nonoperated controls, s

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34

Francisco, Nicole R., Christen M. Raymond, and Paul D. Heideman. "Short photoperiod inhibition of growth in body mass and reproduction in ACI, BUF, and PVG inbred rats." Reproduction 128, no. 6 (2004): 857–62. http://dx.doi.org/10.1530/rep.1.00390.

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Laboratory rats have been generally considered non-photoresponsive, but strains of laboratory rats have been found to be variable for this trait. Young males of both the Fischer (F344) and Brown Norway strains (BN) suppress reproductive development, food intake and body mass in short winter photoperiod (short days (SD); 8 h light:16 h darkness), and food restriction interacts with SD to enhance the effect of SD alone. Conversely, young male Harlan Sprague Dawley outbred rats, along with other outbred laboratory rats tested, have little or no response to SD except when unmasked by food restrict

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35

Baker-Herman, T. L., R. W. Bavis, J. M. Dahlberg, et al. "Differential expression of respiratory long-term facilitation among inbred rat strains." Respiratory Physiology & Neurobiology 170, no. 3 (2010): 260–67. http://dx.doi.org/10.1016/j.resp.2009.12.008.

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36

Golder, Francis J., Andrea G. Zabka, Ryan W. Bavis, Tracy Baker-Herman, David D. Fuller, and Gordon S. Mitchell. "Differences in time-dependent hypoxic phrenic responses among inbred rat strains." Journal of Applied Physiology 98, no. 3 (2005): 838–44. http://dx.doi.org/10.1152/japplphysiol.00984.2004.

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Hypoxic ventilatory responses differ between rodent strains, suggesting a genetic contribution to interindividual variability. However, hypoxic ventilatory responses consist of multiple time-dependent mechanisms that can be observed in different respiratory motor outputs. We hypothesized that strain differences would exist in discrete time-dependent mechanisms of the hypoxic response and, furthermore, that there may be differences between hypoglossal and phrenic nerve responses to hypoxia. Hypoglossal and phrenic nerve responses were assessed during and after a 5-min hypoxic episode in anesthe

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37

Juberg, Daland R., Jenny T. Bond, and Wendell W. Weber. "N-acetylation of aromatic amines: genetic polymorphism in inbred rat strains." Pharmacogenetics 1, no. 1 (1991): 50–57. http://dx.doi.org/10.1097/00008571-199110000-00008.

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38

Bell, R. G., L. Adams, S. Coleman, D. Negrao-Correa, and T. Klei. "Brugia pahangi: Quantitative Analysis of Infection in Several Inbred Rat Strains." Experimental Parasitology 92, no. 2 (1999): 120–30. http://dx.doi.org/10.1006/expr.1999.4411.

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39

Löscher, Wolfgang, Sybille Cramer, and Ulrich Ebert. "Differences in Kindling Development in Seven Outbred and Inbred Rat Strains." Experimental Neurology 154, no. 2 (1998): 551–59. http://dx.doi.org/10.1006/exnr.1998.6948.

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40

van Wijngaarden, Peter, Douglas J. Coster, Helen M. Brereton, Ian L. Gibbins, and Keryn A. Williams. "Strain-Dependent Differences in Oxygen-Induced Retinopathy in the Inbred Rat." Investigative Opthalmology & Visual Science 46, no. 4 (2005): 1445. http://dx.doi.org/10.1167/iovs.04-0708.

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41

Yahata, Takehiro, Fujiya Furuyama, Tomoaki Nagashima, et al. "Thermoregulatory responses of the inbred heat-tolerant FOK rat to cold." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 277, no. 2 (1999): R362—R367. http://dx.doi.org/10.1152/ajpregu.1999.277.2.r362.

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The responses of inbred heat-tolerant FOK rats to cold were compared with those of Wistar King A/H (WKAH) and Std:Wistar (WSTR) strains. The fall of colonic temperature during cold exposure was unexpectedly smaller in FOK than in other groups, but the onset of shivering was delayed in FOK. Norepinephrine (NE)-induced in vivo oxygen consumption and the mitochondrial uncoupling protein 1 level of brown adipose tissue (BAT) were not different among the groups, but the cold-induced increases in in vivo oxygen consumption as well as plasma glycerol and free fatty acids were higher in FOK than in ot

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42

YAMADA, Takahisa, Daniel MORAREJO, Takashi AGUI, and Kozo MATSUMOTO. "Biochemical Polymorphisms in Long-Evans Cinnamon(LEC) Inbred Strain of Rat." Journal of Veterinary Medical Science 55, no. 3 (1993): 491–92. http://dx.doi.org/10.1292/jvms.55.491.

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43

Koster, Andries Sj, Leo Nieuwenhuis, and Ank C. Frankhuijzen-Sierevogel. "Comparison of microsomal drug-metabolizing enzymes in 14 rat inbred strains." Biochemical Pharmacology 38, no. 5 (1989): 759–65. http://dx.doi.org/10.1016/0006-2952(89)90228-1.

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44

Klemcke, Harold G., Bina Joe, Mariam L. Calderon, et al. "Genetic influences on survival time after severe hemorrhage in inbred rat strains." Physiological Genomics 43, no. 12 (2011): 758–65. http://dx.doi.org/10.1152/physiolgenomics.00245.2010.

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To find a genetic basis for differential ability to survive severe hemorrhage, we previously showed eightfold differences in survival times among inbred rat strains. We assumed that rat strains had similar normalized blood volumes (NBV; ml/100 g body wt). As NBV might vary among strains and constitute one genetic variable affecting survival time to hemorrhage, in experiment 1 of the current studies we first measured total blood volumes and calculated NBV in specific inbred rat strains (Brown Norway/Medical College of Wisconsin, BN; Dark Agouti, DA; Fawn Hooded Hypertensive, FHH; Lewis, LEW; an

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Baker, John E., Eugene A. Konorev, Garrett J. Gross, William M. Chilian, and Howard J. Jacob. "Resistance to myocardial ischemia in five rat strains: is there a genetic component of cardioprotection?" American Journal of Physiology-Heart and Circulatory Physiology 278, no. 4 (2000): H1395—H1400. http://dx.doi.org/10.1152/ajpheart.2000.278.4.h1395.

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There is a need to develop new and more consistent animal models of cardioprotection. Traditionally, outbred dogs, rabbits, and rats have been studied. We determined resistance to ischemia in isolated hearts from inbred strains of rats. Hearts from inbred rats: SS/Mcw (Dahl S, Dahl salt-sensitive), DA/Hsd (Dark Agouti), LEW/Hsd (Lewis), and BN/SsN/Mcw (Brown Norway); and from an outbred rat: Hsd:WIST (Wistar) were subjected to 27 min of global, no-flow ischemia, followed by 3 h of reperfusion. Infarct size in the Brown Norway rat was 2.5 times less than that observed in the Dahl S rat, with th

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Zimmerman, Kurt A., Zhengqin Yang, Jeremie M. Lever, et al. "Kidney resident macrophages in the rat have minimal turnover and replacement by blood monocytes." American Journal of Physiology-Renal Physiology 321, no. 2 (2021): F162—F169. http://dx.doi.org/10.1152/ajprenal.00129.2021.

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In this report, we performed parabiosis surgery on inbred Lewis rats and showed that rat kidney resident macrophages (KRMs), identified using our novel cross-species markers, are minimally dependent on peripheral blood input. Thus, for the first time, to our knowledge, we confirm that a hallmark of mouse KRMs is also present in KRMs isolated from another species.

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Sheppard, M. S., and R. M. Bala. "Profile of serum immunoreactive insulin-like growth factor I during gestation in Wistar rats." Canadian Journal of Physiology and Pharmacology 64, no. 5 (1986): 521–24. http://dx.doi.org/10.1139/y86-086.

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It has been reported that there is a striking homology between the basic insulin-like growth factors (IGF) – somatomedins (SM) found in humans and rats. The radioimmunoassay (RIA) developed for the human hormone IGF-I (basic somatomedin, B-SM) can measure immunoreactive IGF-I in rat serum (IrIGF-I). Using this RIA, the profile of serum IrIGF-I was measured at each day of gestation in groups of inbred and Charles River Wistar rats. In each case IrIGF-I showed a gradual increase in early and mid gestation followed by a sharp decrease that occurred late in gestation to values 20–40% of control. T

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Konno, Toshihiro, Lea A. Rempel, M. A. Karim Rumi, et al. "Chromosome-substituted rat strains provide insights into the genetics of placentation." Physiological Genomics 43, no. 15 (2011): 930–41. http://dx.doi.org/10.1152/physiolgenomics.00069.2011.

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The rat possesses a hemochorial form of placentation. Pronounced intrauterine trophoblast cell invasion and vascular remodeling characterize this type of placentation. Strain-specific patterns of placentation are evident in the rat. Some rat strains exhibit deep intrauterine trophoblast invasion and an expanded junctional zone [Holtzman Sprague-Dawley (HSD), Dahl salt sensitive (DSS)], whereas placentation sites of other rat strains are characterized by shallow invasion and a restricted junctional zone [Brown Norway (BN)]. In this report, we identified a quantitative trait that was used to dis

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PRAVENEC, MICHAL, VACLAV ZIDEK, ALENA MUSILOVA, VLADIMIR KŘEN, VLASTA BILA, and ROBERT DI NICOLANTONIO. "Chromosomal Mapping of a Major Quantitative Trait Locus Regulating Compensatory Renal Growth in the Rat." Journal of the American Society of Nephrology 11, no. 7 (2000): 1261–65. http://dx.doi.org/10.1681/asn.v1171261.

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Abstract. Despite extensive research conducted over the past century, the mechanisms of compensatory renal growth (CRG) remain a mystery. Insight into the mechanisms that regulate CRG might be gained by identifying genetic factors that influence this complex phenotype. In a large set of recombinant inbred strains derived from the spontaneously hypertensive rat and the Brown Norway rat, a genome scan for quantitative trait loci (QTL) that regulate CRG was performed. The CRG score was expressed as a ratio of the weight of the remnant right kidney at 8 wk of age to the weight of the left kidney a

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Wang, C. G., G. DiMaria, J. H. Bates, R. D. Guttmann, and J. G. Martin. "Methacholine-induced airway reactivity of inbred rats." Journal of Applied Physiology 61, no. 6 (1986): 2180–85. http://dx.doi.org/10.1152/jappl.1986.61.6.2180.

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Dose-response curves to inhaled aerosolized methacholine chloride (MCh) were obtained in anesthetized spontaneously breathing rats. Thirty rats (10/strain), randomly selected from highly inbred ACI, Lewis (L), and Brown Norway (BN) strains and 40 rats (20/strain) from similarly inbred Wistar-Furth (WF) and Buffalo (Buf) strains were studied. Airway responses were quantitated from changes in pulmonary resistance (RL) and airway reactivity was calculated as the dose of MCh required to increase RL to 150% (ED150RL) and 200% (ED200RL) of base line. There were no statistically significant differenc

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