Academic literature on the topic 'Inbred Strains; Support'

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Journal articles on the topic "Inbred Strains; Support"

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Blount, Jeffrey B., Takeshi Kondoh, Lisa L. Pundt, John Conrad, Elizabeth M. Jansen, and Walter C. Low. "Immunobiology of neural transplants and functional incorporation of grafted dopamine neurons." Behavioral and Brain Sciences 18, no. 1 (1995): 48–49. http://dx.doi.org/10.1017/s0140525x00037286.

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AbstractIn contrast to the views put forth by Stein & Glasier, we support the use of inbred strains of rodents in studies of the immunobiology of neural transplants. Inbred strains demonstrate homology of the major histocompatibility complex (MHC). Virtually all experimental work in transplantation immunology is performed using inbred strains, yet very few published studies of immune rejection in intracerebral grafts have used inbred animals.
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Benhnini, Fouad, Mehdi Chenik, Dhafer Laouini, Hechmi Louzir, Pierre André Cazenave, and Koussay Dellagi. "Comparative Evaluation of Two Vaccine Candidates against Experimental Leishmaniasis Due to Leishmania major Infection in Four Inbred Mouse Strains." Clinical and Vaccine Immunology 16, no. 11 (2009): 1529–37. http://dx.doi.org/10.1128/cvi.00153-09.

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ABSATRCT Experimental leishmaniasis in BALB/c and C57BL/6 mice are the most investigated murine models that were used for the preclinical evaluation of Leishmania vaccine candidates. We have previously described two new inbred mouse strains named PWK and MAI issued from feral founders that also support the development of experimental leishmaniasis due to L. major. In this study, we sought to determine whether different mouse inbred strains generate concordant or discordant results when used to evaluate the potential of Leishmania proteins to protect against experimental leishmaniasis. To this
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van Swinderen, Bruno, Alex Galifianakis, and Michael C. Crowder. "Common Genetic Determinants of Halothane and Isoflurane Potencies in Caenorhabditis elegans." Anesthesiology 89, no. 6 (1998): 1509–17. http://dx.doi.org/10.1097/00000542-199812000-00030.

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Background Genetics provides a way to evaluate anesthetic action simultaneously at the molecular and behavioral levels. Results from strains that differ in anesthetic sensitivity have been mixed in their support of unitary theories of anesthesia. Here the authors use the previously demonstrated large variation of halothane sensitivities in Caenorhabditis elegans recombinant inbred strains to assess the similarities of the determinants of halothane action with those of another volatile anesthetic, isoflurane. Methods The recombinant inbred strains, constructed from two evolutionarily distinct C
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Everett, E. T., M. A. K. McHenry, N. Reynolds, et al. "Dental Fluorosis: Variability among Different Inbred Mouse Strains." Journal of Dental Research 81, no. 11 (2002): 794–98. http://dx.doi.org/10.1177/0810794.

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Concurrent with the decline in dental caries has been an increase in the prevalence of dental fluorosis, a side-effect of exposure to greater than optimal levels of fluoride during amelogenesis. The mechanisms that underlie the pathogenesis of dental fluorosis are not known. We hypothesize that genetic determinants influence an individual’s susceptibility or resistance to develop dental fluorosis. We tested this hypothesis using a mouse model system (continuous eruption of the incisors) where genotype, age, gender, food, housing, and drinking water fluoride level can be rigorously controlled.
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Behmoaras, Jacques, Mary Osborne-Pellegrin, Dominique Gauguier, and Marie-Paule Jacob. "Characteristics of the aortic elastic network and related phenotypes in seven inbred rat strains." American Journal of Physiology-Heart and Circulatory Physiology 288, no. 2 (2005): H769—H777. http://dx.doi.org/10.1152/ajpheart.00544.2004.

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Extracellular matrix (ECM) molecules such as elastin and collagen provide mechanical support to the vessel wall and are essential for vascular function. Evidence that genetic factors influence aortic ECM composition and organization was concluded from our previous studies showing that the inbred Brown Norway (BN) rat differs significantly from the outbred Long-Evans (LE) and the inbred LOU rat with respect to both thoracic aortic elastin content and internal elastic lamina (IEL) rupture in the abdominal aorta and iliac arteries. Here, we measured aortic elastin and collagen contents as well as
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Lightfoot, J. Timothy, Larry Leamy, Daniel Pomp, et al. "Strain screen and haplotype association mapping of wheel running in inbred mouse strains." Journal of Applied Physiology 109, no. 3 (2010): 623–34. http://dx.doi.org/10.1152/japplphysiol.00525.2010.

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Previous genetic association studies of physical activity, in both animal and human models, have been limited in number of subjects and genetically homozygous strains used as well as number of genomic markers available for analysis. Expansion of the available mouse physical activity strain screens and the recently published dense single-nucleotide polymorphism (SNP) map of the mouse genome (≈8.3 million SNPs) and associated statistical methods allowed us to construct a more generalizable map of the quantitative trait loci (QTL) associated with physical activity. Specifically, we measured wheel
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Whitehead, Gregory S., Julia K. L. Walker, Katherine G. Berman, W. Michael Foster, and David A. Schwartz. "Allergen-induced airway disease is mouse strain dependent." American Journal of Physiology-Lung Cellular and Molecular Physiology 285, no. 1 (2003): L32—L42. http://dx.doi.org/10.1152/ajplung.00390.2002.

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We investigated the development of airway hyperreactivity (AHR) and inflammation in the lungs of nine genetically diverse inbred strains of mice [129/SvIm, A/J, BALB/cJ, BTBR+(T)/tf/tf, CAST/Ei, C3H/HeJ, C57BL/6J, DBA/2J, and FVB/NJ] after sensitization and challenge with ovalbumin (OVA). At 24, 48, and 72 h post-OVA exposure, the severity of AHR and eosinophilic inflammation of the mouse strains ranged from relatively unresponsive to responsive. The severity of the airway eosinophilia of some strains did not clearly correlate with the development of AHR. The temporal presence of T helper type
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Fiette, L., C. Aubert, U. Müller, et al. "Theiler's virus infection of 129Sv mice that lack the interferon alpha/beta or interferon gamma receptors." Journal of Experimental Medicine 181, no. 6 (1995): 2069–76. http://dx.doi.org/10.1084/jem.181.6.2069.

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The Daniels strain of Theiler's virus causes a persistent infection of the white matter of spinal cord of susceptible mice, with chronic inflammation and primary demyelination. Inbred 129Sv mice are resistant to this infection; they present with mild encephalomyelitis and clear the infection within a matter of days. A very different outcome was observed with inbred 129Sv mice whose receptors for interferon alpha/beta or interferon gamma had been inactivated by homologous recombination. The former presented severe encephalomyelitis with acute infection of neurons, particularly in brain and hipp
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KOCH, LAUREN GERARD, STEVEN L. BRITTON, JOHN C. BARBATO, DAVID W. RODENBAUGH, and STEPHEN E. DiCARLO. "Phenotypic differences in cardiovascular regulation in inbred rat models of aerobic capacity." Physiological Genomics 1, no. 2 (1999): 63–69. http://dx.doi.org/10.1152/physiolgenomics.1999.1.2.63.

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Koch, Lauren Gerard, Steven L. Britton, John C. Barbato, David W. Rodenbaugh, and Stephen E. DiCarlo. Phenotypic differences in cardiovascular regulation in inbred rat models of aerobic capacity. Physiol. Genomics 63–69, 1999.—The Dark Aouti (DA) inbred strain of rats has superior aerobic treadmill running capacity compared with the Copenhagen (COP) strain of inbred rats. This difference in aerobic capacity provides a model to explore the genetic basis of variation in this trait. The present study evaluated intermediate phenotypic differences between 10 male COP inbred rats and 10 male DA inbr
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Simon, Holly M., Kevin P. Smith, Jeremy A. Dodsworth, Bobbi Guenthner, Jo Handelsman, and Robert M. Goodman. "Influence of Tomato Genotype on Growth of Inoculated and Indigenous Bacteria in the Spermosphere." Applied and Environmental Microbiology 67, no. 2 (2001): 514–20. http://dx.doi.org/10.1128/aem.67.2.514-520.2001.

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ABSTRACT We previously demonstrated a genetic basis in tomato for support of the growth of a biological control agent, Bacillus cereusUW85, in the spermosphere after seed inoculation (K. P. Smith, J. Handelsman, and R. M. Goodman, Proc. Natl. Acad. Sci. USA 96:4786–4790, 1999). Here we report results of studies examining the host effect on the support of growth of Bacillus andPseudomonas strains, both inoculated on seeds and recruited from soil, using selected inbred tomato lines from the recombinant inbred line (RIL) population used in our previous study. Two tomato lines, one previously foun
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Reports on the topic "Inbred Strains; Support"

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Harman, Gary E., and Ilan Chet. Enhancement of plant disease resistance and productivity through use of root symbiotic fungi. United States Department of Agriculture, 2008. http://dx.doi.org/10.32747/2008.7695588.bard.

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The objectives of the project were to (a) compare effects ofT22 and T-203 on growth promotion and induced resistance of maize inbred line Mol7; (b) follow induced resistance of pathogenesis-related proteins through changes in gene expression with a root and foliar pathogen in the presence or absence of T22 or T-203 and (c) to follow changes in the proteome of Mol? over time in roots and leaves in the presence or absence of T22 or T-203. The research built changes in our concepts regarding the effects of Trichoderma on plants; we hypothesized that there would be major changes in the physiology
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