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Journal articles on the topic 'Inbred Strains; Support'

Author: Grafiati
Published: 3 June 2025
Last updated: 31 July 2025

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1

Blount, Jeffrey B., Takeshi Kondoh, Lisa L. Pundt, John Conrad, Elizabeth M. Jansen, and Walter C. Low. "Immunobiology of neural transplants and functional incorporation of grafted dopamine neurons." Behavioral and Brain Sciences 18, no. 1 (1995): 48–49. http://dx.doi.org/10.1017/s0140525x00037286.

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AbstractIn contrast to the views put forth by Stein & Glasier, we support the use of inbred strains of rodents in studies of the immunobiology of neural transplants. Inbred strains demonstrate homology of the major histocompatibility complex (MHC). Virtually all experimental work in transplantation immunology is performed using inbred strains, yet very few published studies of immune rejection in intracerebral grafts have used inbred animals.
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2

Benhnini, Fouad, Mehdi Chenik, Dhafer Laouini, Hechmi Louzir, Pierre André Cazenave, and Koussay Dellagi. "Comparative Evaluation of Two Vaccine Candidates against Experimental Leishmaniasis Due to Leishmania major Infection in Four Inbred Mouse Strains." Clinical and Vaccine Immunology 16, no. 11 (2009): 1529–37. http://dx.doi.org/10.1128/cvi.00153-09.

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ABSATRCT Experimental leishmaniasis in BALB/c and C57BL/6 mice are the most investigated murine models that were used for the preclinical evaluation of Leishmania vaccine candidates. We have previously described two new inbred mouse strains named PWK and MAI issued from feral founders that also support the development of experimental leishmaniasis due to L. major. In this study, we sought to determine whether different mouse inbred strains generate concordant or discordant results when used to evaluate the potential of Leishmania proteins to protect against experimental leishmaniasis. To this
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3

van Swinderen, Bruno, Alex Galifianakis, and Michael C. Crowder. "Common Genetic Determinants of Halothane and Isoflurane Potencies in Caenorhabditis elegans." Anesthesiology 89, no. 6 (1998): 1509–17. http://dx.doi.org/10.1097/00000542-199812000-00030.

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Background Genetics provides a way to evaluate anesthetic action simultaneously at the molecular and behavioral levels. Results from strains that differ in anesthetic sensitivity have been mixed in their support of unitary theories of anesthesia. Here the authors use the previously demonstrated large variation of halothane sensitivities in Caenorhabditis elegans recombinant inbred strains to assess the similarities of the determinants of halothane action with those of another volatile anesthetic, isoflurane. Methods The recombinant inbred strains, constructed from two evolutionarily distinct C
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Everett, E. T., M. A. K. McHenry, N. Reynolds, et al. "Dental Fluorosis: Variability among Different Inbred Mouse Strains." Journal of Dental Research 81, no. 11 (2002): 794–98. http://dx.doi.org/10.1177/0810794.

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Concurrent with the decline in dental caries has been an increase in the prevalence of dental fluorosis, a side-effect of exposure to greater than optimal levels of fluoride during amelogenesis. The mechanisms that underlie the pathogenesis of dental fluorosis are not known. We hypothesize that genetic determinants influence an individual’s susceptibility or resistance to develop dental fluorosis. We tested this hypothesis using a mouse model system (continuous eruption of the incisors) where genotype, age, gender, food, housing, and drinking water fluoride level can be rigorously controlled.
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5

Behmoaras, Jacques, Mary Osborne-Pellegrin, Dominique Gauguier, and Marie-Paule Jacob. "Characteristics of the aortic elastic network and related phenotypes in seven inbred rat strains." American Journal of Physiology-Heart and Circulatory Physiology 288, no. 2 (2005): H769—H777. http://dx.doi.org/10.1152/ajpheart.00544.2004.

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Extracellular matrix (ECM) molecules such as elastin and collagen provide mechanical support to the vessel wall and are essential for vascular function. Evidence that genetic factors influence aortic ECM composition and organization was concluded from our previous studies showing that the inbred Brown Norway (BN) rat differs significantly from the outbred Long-Evans (LE) and the inbred LOU rat with respect to both thoracic aortic elastin content and internal elastic lamina (IEL) rupture in the abdominal aorta and iliac arteries. Here, we measured aortic elastin and collagen contents as well as
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Lightfoot, J. Timothy, Larry Leamy, Daniel Pomp, et al. "Strain screen and haplotype association mapping of wheel running in inbred mouse strains." Journal of Applied Physiology 109, no. 3 (2010): 623–34. http://dx.doi.org/10.1152/japplphysiol.00525.2010.

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Previous genetic association studies of physical activity, in both animal and human models, have been limited in number of subjects and genetically homozygous strains used as well as number of genomic markers available for analysis. Expansion of the available mouse physical activity strain screens and the recently published dense single-nucleotide polymorphism (SNP) map of the mouse genome (≈8.3 million SNPs) and associated statistical methods allowed us to construct a more generalizable map of the quantitative trait loci (QTL) associated with physical activity. Specifically, we measured wheel
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7

Whitehead, Gregory S., Julia K. L. Walker, Katherine G. Berman, W. Michael Foster, and David A. Schwartz. "Allergen-induced airway disease is mouse strain dependent." American Journal of Physiology-Lung Cellular and Molecular Physiology 285, no. 1 (2003): L32—L42. http://dx.doi.org/10.1152/ajplung.00390.2002.

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We investigated the development of airway hyperreactivity (AHR) and inflammation in the lungs of nine genetically diverse inbred strains of mice [129/SvIm, A/J, BALB/cJ, BTBR+(T)/tf/tf, CAST/Ei, C3H/HeJ, C57BL/6J, DBA/2J, and FVB/NJ] after sensitization and challenge with ovalbumin (OVA). At 24, 48, and 72 h post-OVA exposure, the severity of AHR and eosinophilic inflammation of the mouse strains ranged from relatively unresponsive to responsive. The severity of the airway eosinophilia of some strains did not clearly correlate with the development of AHR. The temporal presence of T helper type
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8

Fiette, L., C. Aubert, U. Müller, et al. "Theiler's virus infection of 129Sv mice that lack the interferon alpha/beta or interferon gamma receptors." Journal of Experimental Medicine 181, no. 6 (1995): 2069–76. http://dx.doi.org/10.1084/jem.181.6.2069.

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The Daniels strain of Theiler's virus causes a persistent infection of the white matter of spinal cord of susceptible mice, with chronic inflammation and primary demyelination. Inbred 129Sv mice are resistant to this infection; they present with mild encephalomyelitis and clear the infection within a matter of days. A very different outcome was observed with inbred 129Sv mice whose receptors for interferon alpha/beta or interferon gamma had been inactivated by homologous recombination. The former presented severe encephalomyelitis with acute infection of neurons, particularly in brain and hipp
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9

KOCH, LAUREN GERARD, STEVEN L. BRITTON, JOHN C. BARBATO, DAVID W. RODENBAUGH, and STEPHEN E. DiCARLO. "Phenotypic differences in cardiovascular regulation in inbred rat models of aerobic capacity." Physiological Genomics 1, no. 2 (1999): 63–69. http://dx.doi.org/10.1152/physiolgenomics.1999.1.2.63.

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Koch, Lauren Gerard, Steven L. Britton, John C. Barbato, David W. Rodenbaugh, and Stephen E. DiCarlo. Phenotypic differences in cardiovascular regulation in inbred rat models of aerobic capacity. Physiol. Genomics 63–69, 1999.—The Dark Aouti (DA) inbred strain of rats has superior aerobic treadmill running capacity compared with the Copenhagen (COP) strain of inbred rats. This difference in aerobic capacity provides a model to explore the genetic basis of variation in this trait. The present study evaluated intermediate phenotypic differences between 10 male COP inbred rats and 10 male DA inbr
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10

Simon, Holly M., Kevin P. Smith, Jeremy A. Dodsworth, Bobbi Guenthner, Jo Handelsman, and Robert M. Goodman. "Influence of Tomato Genotype on Growth of Inoculated and Indigenous Bacteria in the Spermosphere." Applied and Environmental Microbiology 67, no. 2 (2001): 514–20. http://dx.doi.org/10.1128/aem.67.2.514-520.2001.

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ABSTRACT We previously demonstrated a genetic basis in tomato for support of the growth of a biological control agent, Bacillus cereusUW85, in the spermosphere after seed inoculation (K. P. Smith, J. Handelsman, and R. M. Goodman, Proc. Natl. Acad. Sci. USA 96:4786–4790, 1999). Here we report results of studies examining the host effect on the support of growth of Bacillus andPseudomonas strains, both inoculated on seeds and recruited from soil, using selected inbred tomato lines from the recombinant inbred line (RIL) population used in our previous study. Two tomato lines, one previously foun
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11

Fryou, Noah, Mingjia Li, and Bernard Possidente. "0019 Assessing Genetic Variation for Effects of Lithium on Circadian Clock Period and Mortality in Fruit Flies." SLEEP 46, Supplement_1 (2023): A8—A9. http://dx.doi.org/10.1093/sleep/zsad077.0019.

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Abstract Introduction Lithium is the treatment of choice for bipolar disorder, but the mechanism for its therapeutic effect remains unknown, and it has a low threshold for toxic side-effects. Bipolar disorder is cyclical disorder with periodic onsets of illness including depressive and manic episode that vary in cycle length among patients. One of lithium’s well-documented effects- a lengthened circadian clock period- is intriguing since a circadian system abnormality is a potential explanation for the cyclical nature of bipolar disorder. Fruit flies are an efficient model organism for genetic
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12

TIMOTHY, L. M., and J. M. BEHNKE. "Necator americanus in inbred mice: evidence in support of genetically determined differences in the cellular immune response to a primary infection." Parasitology 114, no. 1 (1997): 53–63. http://dx.doi.org/10.1017/s0031182096008189.

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The blood and broncho-alveolar leucocyte (BAL) responses, to a primary Necator americanus infection, were studied in male BALB/c and NIH mice. Following percutaneous infection, a significant blood leucocytosis occurred in both the BALB/c and NIH strains. The peak response occurred, in both strains, on day 10 p.i. and this was reflected in the eosinophil response which peaked at the same time-point. The change in blood eosinophil numbers, as a result of infection, was found to be the greatest recorded for any cell type. In BALB/c mice, however, infection elicited a significantly more intense to
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13

Kito, Seiji, and Yuki Ohta. "Medium effects on capacitation and sperm penetration through the zona pellucida in inbred BALB/c spermatozoa." Zygote 13, no. 2 (2005): 145–53. http://dx.doi.org/10.1017/s0967199405003205.

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Inbred BALB/c mice are one of the most difficult inbred strains to fertilize in vitro. In this study we examined the abilities of various media used for mouse in vitro fertilization (IVF) to support capacitation and sperm penetration through the zona pellucida (ZP) of inbred BALB/c spermatozoa. Media examined were TYH, M16, CZB, mWhitten medium, T6, modified Tyrode's solution (mTyrode's), mKSOM, MEM and TCM199. Modified human tubal fluid (mHTF) was used as a control medium. When sperm were capacitated and inseminated in the same medium, mHTF showed the best fertilization (approximately 80%) sc
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14

Flebbe, L., S. W. Vukajlovich, and D. C. Morrison. "Immunostimulation of C3H/HeJ lymphoid cells by R-chemotype lipopolysaccharide preparations." Journal of Immunology 142, no. 2 (1989): 642–52. http://dx.doi.org/10.4049/jimmunol.142.2.642.

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Abstract Splenocytes from the C3H/HeJ and C57BL/10ScN (nu/nu) inbred mouse strains have been characterized by a genetic defect in their capacity to proliferate in response to purified protein-free LPS preparations. In this manuscript we provide experimental evidence to support the concept that the refractory state of B cells from endotoxin-unresponsive mice to mitogenic stimulation by LPS does not extend to R-chemotype LPS isolated from a variety of rough strains of Salmonella or Escherichia coli. We present several lines of evidence to suggest that the observed mitogenic activity is not the r
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15

Fitzpatrick, Elizabeth, Tae-Won Yoon, Robert Williams, and Ae-Kyung Yi. "Effect of genetics on the development of Hypersensitivity Pneumonitis (HP) using the BXD recombinant inbred mouse reference population." Journal of Immunology 198, no. 1_Supplement (2017): 53.10. http://dx.doi.org/10.4049/jimmunol.198.supp.53.10.

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Abstract HP is an interstitial lung disease that develops following repeated exposure to a variety of inhaled environmental antigens. The disease is characterized by alveolitis, granulomas and in some patients, develops into a chronic form associated with fibrosis. Not all individuals exposed to HP causative antigens develop disease suggesting that genetic factors play a role in susceptibility; however, the host co-factor(s) that play a role in susceptibility are unknown. We are using the innovative systems genetics tool, the BXD panel of recombinant inbred mice with the Saccharopolyspora rect
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16

Prows, Daniel R., Mark J. Daly, Howard G. Shertzer, and George D. Leikauf. "Ozone-induced acute lung injury: genetic analysis of F2 mice generated from A/J and C57BL/6J strains." American Journal of Physiology-Lung Cellular and Molecular Physiology 277, no. 2 (1999): L372—L380. http://dx.doi.org/10.1152/ajplung.1999.277.2.l372.

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Acute lung injury (or acute respiratory distress syndrome) is a devastating and often lethal condition. This complex disease (trait) may be associated with numerous candidate genes. To discern the major gene(s) controlling mortality from acute lung injury, two inbred mouse strains displaying contrasting survival times to 10 parts/million ozone were identified. A/J (A) mice were sensitive [6.6 ± 1 (SE) h] and C57BL/6J (B) were resistant (20.6 ± 1 h). The designation for these phenotypes was 13 h, a point that clearly separated their survival time distributions. Our prior segregation studies sug
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17

Nguyen, Peter V., Steven N. Duffy, and Jennie Z. Young. "Differential Maintenance and Frequency-Dependent Tuning of LTP at Hippocampal Synapses of Specific Strains of Inbred Mice." Journal of Neurophysiology 84, no. 5 (2000): 2484–93. http://dx.doi.org/10.1152/jn.2000.84.5.2484.

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Transgenic and knockout mice are used extensively to elucidate the molecular mechanisms of hippocampal synaptic plasticity. However, genetic and phenotypic variations between inbred mouse strains that are used to construct genetic models may confound the interpretation of cellular neurophysiological data derived from these models. Using in vitro slice stimulation and recording methods, we compared the membrane biophysical, cellular electrophysiological, and synaptoplastic properties of hippocampal CA1 neurons in four specific strains of inbred mice: C57BL/6J, CBA/J, DBA/2J, and 129/SvEms/J. Hi
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18

Else, Kathryn, and D. Wakelin. "The effects of H-2 and non-H-2 genes on the expulsion of the nematode Trichuris muris from inbred and congenic mice." Parasitology 96, no. 3 (1988): 543–50. http://dx.doi.org/10.1017/s0031182000080173.

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SUMMARYTwo groups of H-2 congenic strains of mice were compared for their susceptibility to a primary infection with the nematode Trichuris muris. Mice of the BALB genetic background were markedly more resistant than mice of the BIO genetic background, as reflected by the rate of expulsion of T. muris from the large intestine. Within each of the two groups of H-2 congenic strains mice possessing the H-2k haplotype (BALB/k, B10.BR) were more susceptible to infection than mice expressing other haplotypes; B10 background strains expressing H-2b (B10) or H-2q (B10.G) alleles were the most resistan
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Brown, A. Ross, David J. Hosken, François Balloux, et al. "Genetic variation, inbreeding and chemical exposure—combined effects in wildlife and critical considerations for ecotoxicology." Philosophical Transactions of the Royal Society B: Biological Sciences 364, no. 1534 (2009): 3377–90. http://dx.doi.org/10.1098/rstb.2009.0126.

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Exposure to environmental chemicals can have negative consequences for wildlife and even cause localized population extinctions. Resistance to chemical stress, however, can evolve and the mechanisms include desensitized target sites, reduced chemical uptake and increased metabolic detoxification and sequestration. Chemical resistance in wildlife populations can also arise independently of exposure and may be spread by gene flow between populations. Inbreeding—matings between closely related individuals—can have negative fitness consequences for natural populations, and there is evidence of inb
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20

Roux, Candice M., Pierre Lecouflet, Jean-Marie Billard, et al. "Genetic Background Influence on Hippocampal Synaptic Plasticity: Frequency-Dependent Variations between an Inbred and an Outbred Mice Strain." International Journal of Molecular Sciences 24, no. 5 (2023): 4304. http://dx.doi.org/10.3390/ijms24054304.

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For almost half a century, acute hippocampal slice preparations have been widely used to investigate anti-amnesic (or promnesic) properties of drug candidates on long-term potentiation (LTP)—a cellular substrate that supports some forms of learning and memory. The large variety of transgenic mice models now available makes the choice of the genetic background when designing experiments crucially important. Furthermore, different behavioral phenotypes were reported between inbred and outbred strains. Notably, some differences in memory performance were emphasized. Despite this, investigations,
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Babay, Besma E. C., Hechmi Louzir, Chahnaz Kebaïer, Samir Boubaker, Koussay Dellagi, and Pierre-André Cazenave. "Inbred Strains Derived from Feral Mice Reveal New Pathogenic Mechanisms of Experimental Leishmaniasis Due to Leishmania major." Infection and Immunity 72, no. 8 (2004): 4603–11. http://dx.doi.org/10.1128/iai.72.8.4603-4611.2004.

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ABSTRACT Two inbred mouse strains, derived from feral founders, are susceptible to experimental leishmaniasis due to Leishmania major and support a disease of a severity intermediate between those observed in strains C57BL/6 and BALB/c. Mice of the MAI strain develop a severe, nonhealing, but nonfatal disease with no resistance to a secondary parasite challenge. The immunological responses showed a TH2 dominance characterized by an early peak of interleukin-4 (IL-4) and IL-13. However, neutralization of IL-4, which leads to a resistance phenotype in BALB/c mice, has no effect on disease progre
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Raza, Abbas, Sean A. Diehl, Kristiaan H. Finstad, et al. "Genetic analysis of Bphse and Shs, novel loci controlling hypersensitivity to histamine in mice." Journal of Immunology 200, no. 1_Supplement (2018): 104.10. http://dx.doi.org/10.4049/jimmunol.200.supp.104.10.

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Abstract Histamine (HA) is a biogenic amine produced by mast cells and basophils that regulates many physiological processes including acute and chronic inflammation, immune regulation, and immediate hypersensitivity reactions. Previously, we mapped Bphs, the autosomal dominant locus in mice controlling hypersensitivity to HA following exposure to either Bordetella pertussis or pertussis toxin (PTX) to chromosome 6 (Chr6). Positional candidate gene cloning identified Bphs as HA H1 receptor (Hrh1/H1R). The Bphs-susceptible H1R allele possesses the Pro263, Val312 and Pro330 haplotype while the B
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23

Pitman, Wendy A., Ron Korstanje, Gary A. Churchill, et al. "Quantitative trait locus mapping of genes that regulate HDL cholesterol in SM/J and NZB/B1NJ inbred mice." Physiological Genomics 9, no. 2 (2002): 93–102. http://dx.doi.org/10.1152/physiolgenomics.00107.2001.

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To investigate the quantitative trait loci (QTL) regulating plasma cholesterol, the female progeny of an (SM×NZB/ B1NJ)×NZB/B1NJ backcross were fed an atherogenic diet. After 18 wk, plasma total cholesterol and high-density lipoprotein cholesterol (HDL-C) was measured. HDL-C concentrations were greater in NZB than in SM mice. For standard chow-fed mice, QTL were found near D5Mit370 and D18Mit34. For mice fed an atherogenic diet, a QTL was found near D5Mit239. The QTL for chow-fed and atherogenic-fed mice on chromosome 5 seem to be two different loci. We used a multitrait analysis to rule out p
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Cortopassi, Gino A., and Allan C. Wilson. "Genetic analysis of a switch in cell specificity of P lysozyme expression in molossinus mice." Genetical Research 58, no. 2 (1991): 111–14. http://dx.doi.org/10.1017/s001667230002975x.

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SummaryAn electrophoretic survey of concentrations of lysozymes M and P was carried out with seven species in the house mouse group (spretus, hortulanus, abbotti, musculus, castaneus, domesticus and molossinus). In most species M is the predominant lysozyme in all tissues tested, except the small intestine, where P predominates if present. In inbred strains of molossinus mice P is more abundant than M in all tissues tested. The phenotypes of high expression of P lysozyme and low expression of M lysozyme in peritoneal and alveolar macrophages were examined genetically. Results of interspecific
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25

Genzer, Sarah C., Timothy Flietstra, JoAnn D. Coleman-McCray, Cassandra Tansey, Stephen R. Welch, and Jessica R. Spengler. "Effect of Parental Age, Parity, and Pairing Approach on Reproduction in Strain 13/N Guinea Pigs (Cavia porcellus)." Animals 13, no. 5 (2023): 895. http://dx.doi.org/10.3390/ani13050895.

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Guinea pigs are important animal models for human disease, and both outbred and inbred lines are utilized in biomedical research. The optimal maintenance of guinea pig colonies, commercially and in research settings, relies on robust informed breeding programs, however, breeding data on specialized inbred strains are limited. Here, we investigated the effects of parental age, parity, and pairing approaches on mean total fetus count, percentage of female pups in the litter, and pup survival rate after 10 days in strain 13/N guinea pigs. Our analysis of colony breeding data indicates that the av
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26

Martin, Matthew D., Ramakrishna Sompallae, Christina Winborn, John T. Harty, and Vladimir P. Badovinac. "Diverse CD8 T cell responses to infection revealed by the collaborative cross." Journal of Immunology 204, no. 1_Supplement (2020): 95.16. http://dx.doi.org/10.4049/jimmunol.204.supp.95.16.

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Abstract Enhanced host protection against re-infection requires generation of memory T cells of sufficient quantity and functional quality. Unlike well-studied inbred mice, T cell responses of diverse size and quality are generated following infection of humans and outbred mice. Thus, additional models are needed that more accurately reflect variation in immune outcomes in genetically diverse populations and to uncover underlying genetic causes. The Collaborative Cross (CC), a large recombinant inbred panel of mice, is an ideal model in this pursuit due to the high degree of genetic variation
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REICH, MICHAEL S., JOSEPH P. JARVIS, MATTHEW J. SILVA, and JAMES M. CHEVERUD. "Genetic relationships between obesity and osteoporosis in LGXSM recombinant inbred mice." Genetics Research 90, no. 5 (2008): 433–44. http://dx.doi.org/10.1017/s0016672308009798.

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SummaryObesity and osteoporosis affect millions of Americans. While phenotypically, obesity is negatively correlated with fracture risk, research on a genetic basis for this relationship is lacking. We used males and females from 16 LGXSM recombinant inbred (RI) mouse strains to investigate the genetically mediated relationship between obesity and osteoporosis-related traits. First, heritabilities were estimated for (1) bone morphology properties determined by microCT (femoral and radial diaphyseal bone cross-sectional area and moments of inertia, as well as proximal tibial trabecular bone vol
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Onwochei, M. O., R. M. Snajdar, and J. P. Rapp. "Release of atrial natriuretic factor from heart-lung preparations of inbred Dahl rats." American Journal of Physiology-Heart and Circulatory Physiology 253, no. 5 (1987): H1044—H1052. http://dx.doi.org/10.1152/ajpheart.1987.253.5.h1044.

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Isolated heart-lung preparations from hypertensive inbred Dahl salt-hypertension sensitive (S) and normotensive inbred Dahl salt-hypertension resistant (R) rats were perfused using 15% washed rat red blood cells in Krebs-Ringer bicarbonate buffer. Atrial pressures were increased by increasing venous return (preload) or by increasing the arterial resistance (afterload). Increases in preload at a constant afterload produced increases in the right and left atrial pressures equivalent between S and R strains. Atrial natriuretic factor (ANF) release was linearly related to right atrial pressure (RA
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Watarai, Masahisa, Isabelle Derre, James Kirby, Joseph D. Growney, William F. Dietrich, and Ralph R. Isberg. "Legionella pneumophila Is Internalized by a Macropinocytotic Uptake Pathway Controlled by the Dot/Icm System and the Mouse Lgn1 Locus✪." Journal of Experimental Medicine 194, no. 8 (2001): 1081–96. http://dx.doi.org/10.1084/jem.194.8.1081.

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The products of the Legionella pneumophila dot/icm genes enable the bacterium to replicate within a macrophage vacuole. This study demonstrates that the Dot/Icm machinery promotes macropinocytotic uptake of L. pneumophila into mouse macrophages. In mouse strains harboring a permissive Lgn1 allele, L. pneumophila promoted formation of vacuoles that were morphologically similar to macropinosomes and dependent on the presence of an intact Dot/Icm system. Macropinosome formation appeared to occur during, rather than after, the closure of the plasma membrane about the bacterium, since a fluid-phase
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Klante, Gabriela, Karin Secci, Mireille Masson-Pévet, et al. "Interstrain differences in activity pattern, pineal function, and SCN melatonin receptor density of rats." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 276, no. 4 (1999): R1078—R1086. http://dx.doi.org/10.1152/ajpregu.1999.276.4.r1078.

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We investigated the possibility that strain-dependent differences in the diurnal pattern of wheel running activity rhythms are also reflected in the melatonin profiles. The inbred rat strains ACI/Ztm, BH/Ztm, and LEW/Ztm. LEW were examined for diurnal [12:12-h light-dark (LD)] wheel running activity, urinary 6-sulphatoxymelatonin (aMT6s) excretion, melatonin concentrations of plasma and pineal glands, and melatonin receptor density in the suprachiasmatic nuclei (SCN). ACI rats displayed unimodal activity patterns with a high level of activity, whereas BH and LEW rats showed multimodal activity
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Riley, D., M. Dwinell, B. Qian, et al. "Differences between three inbred rat strains in number of K+ channel-immunoreactive neurons in the medullary raphé nucleus." Journal of Applied Physiology 108, no. 4 (2010): 1003–10. http://dx.doi.org/10.1152/japplphysiol.00625.2009.

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Ventilatory sensitivity to hypercapnia is greater in Dahl salt-sensitive (SS) rats than in Fawn Hooded hypertensive (FHH) and Brown Norway (BN) inbred rats. Since pH-sensitive potassium ion (K+) channels are postulated to contribute to the sensing and signaling of changes in CO2-H+ in chemosensitive neurons, we tested the hypothesis that there are more pH-sensitive K+ channel-immunoreactive (ir) neurons within the medullary raphé nuclei of the highly chemosensitive SS rats than in the other two strains. Medullary tissues from male and female BN, FHH, and SS rats were stained with cresyl violet
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Horváth, János, Balázs Barkóczi, Géza Müller, and Viktor Szegedi. "Anxious and Nonanxious Mice Show Similar Hippocampal Sensory Evoked Oscillations under Urethane Anesthesia: Difference in the Effect of Buspirone." Neural Plasticity 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/186323.

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Hippocampal oscillations recorded under urethane anesthesia are proposed to be modulated by anxiolytics. All classes of clinically effective anxiolytics were reported to decrease the frequency of urethane theta; however, recent findings raise concerns about the direct correlation of anxiolysis and the frequency of hippocampal theta. Here, we took advantage of our two inbred mouse strains displaying extremes of anxiety (anxious (AX) and nonanxious (nAX)) to compare the properties of hippocampal activity and to test the effect of an anxiolytic drugs. No difference was observed in the peak freque
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33

Payton, Colin D., and J. M. Boulton-Jones. "Genetic Factors in the Development of Nephropathy in Diabetic Lewis and Da Rats." Clinical Science 77, no. 5 (1989): 521–27. http://dx.doi.org/10.1042/cs0770521.

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1. Streptozotocin was used to induce diabetes in two inbred strains of rats, Lewis and DA, known to have different glomerular properties. 2. Dietary protein intake, weight and plasma glucose were monitored during the course of the experiment, and, at regular intervals, urine collections were made utilizing metabolic cages. 3. No significant differences were found in protein intake or plasma glucose between the two strains. 4. Proteinuria was higher in the diabetic Lewis rats than in the diabetic DA rats, and the difference became progressively greater with the passage of time. After 6 months o
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34

Hirai, Asuka, Nobuhisa Ohtsuka, Toshio Ikeda, et al. "Role of Mouse Hepatitis Virus (MHV) Receptor Murine CEACAM1 in the Resistance of Mice to MHV Infection: Studies of Mice with Chimeric mCEACAM1a and mCEACAM1b." Journal of Virology 84, no. 13 (2010): 6654–66. http://dx.doi.org/10.1128/jvi.02680-09.

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ABSTRACT Although most inbred mouse strains are highly susceptible to mouse hepatitis virus (MHV) infection, the inbred SJL line of mice is highly resistant to its infection. The principal receptor for MHV is murine CEACAM1 (mCEACAM1). Susceptible strains of mice are homozygous for the 1a allele of mCeacam1, while SJL mice are homozygous for the 1b allele. mCEACAM1a (1a) has a 10- to 100-fold-higher receptor activity than does mCEACAM1b (1b). To explore the hypothesis that MHV susceptibility is due to the different MHV receptor activities of 1a and 1b, we established a chimeric C57BL/6 mouse (
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35

Khan, Asis, Ayako Wendy Fujita, Nadine Randle, et al. "Global selective sweep of a highly inbred genome of the cattle parasite Neospora caninum." Proceedings of the National Academy of Sciences 116, no. 45 (2019): 22764–73. http://dx.doi.org/10.1073/pnas.1913531116.

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Neospora caninum, a cyst-forming apicomplexan parasite, is a leading cause of neuromuscular diseases in dogs as well as fetal abortion in cattle worldwide. The importance of the domestic and sylvatic life cycles of Neospora, and the role of vertical transmission in the expansion and transmission of infection in cattle, is not sufficiently understood. To elucidate the population genomics of Neospora, we genotyped 50 isolates collected worldwide from a wide range of hosts using 19 linked and unlinked genetic markers. Phylogenetic analysis and genetic distance indices resolved a single genotype o
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36

Wagoner, Wendy J., Jill A. Kellogg, Richard K. Bestwick, and James A. Stamp. "SUPERIOR REGENERATION AND AGROBACTERIUM INFECTABILITY OF BROCCOLI AND CAULIFLOWER TISSUES AND THE IDENTIFICATION OF A PROCEDURE FOR THE GENERATION OF TRANSGENIC PLANTS." HortScience 27, no. 6 (1992): 620f—621. http://dx.doi.org/10.21273/hortsci.27.6.620f.

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Broccoli and cauliflower are among the most regeneratively intractable genotypes found in the brassicaceae. To develop a method for transfer of the gene encoding S-adenosylmethionine hydrolase (SAMase) into inbred broccoli and cauliflower germplasm, we investigated the morphogenic competence and Agrobacterium susceptibility of a wide range of tissues of varied source. Appropriately controlled expression of the SAMase gene should, theoretically, reduce the plant's capacity for ethylene biosynthesis and extend the post harvest shelf life of the flower head. Through examination of the in vitro re
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37

Walker, Jon P., John C. Barbato, and Lauren Gerard Koch. "Cardiac adenosine production in rat genetic models of low and high exercise capacity." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 283, no. 1 (2002): R168—R173. http://dx.doi.org/10.1152/ajpregu.00621.2001.

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We previously demonstrated that Copenhagen (COP) and DA inbred rat strains show a wide difference in a test for aerobic treadmill running that correlated positively with isolated cardiac function. The purpose of this study was to test adenosine production as a candidate intermediate phenotype that may explain part of the difference in running and cardiac performance in these genetic models for low and high aerobic capacity. Adenosine production was measured as the activity of soluble 5′-nucleotidase and membrane-bound ecto-5′-nucleotidase in the membrane pellet and supernatant fractions of lef
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38

Bix, Mark, Shangli Lian та Meenu Pillai. "Host resistance to a gastrointestinal parasite regulated by a SNP modulating SMAD3 binding to a TGFβ-regulated transcriptional enhancer of Mina, encoding an immunoregulatory member of the Jmjc protein family (70.9)". Journal of Immunology 188, № 1_Supplement (2012): 70.9. http://dx.doi.org/10.4049/jimmunol.188.supp.70.9.

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Abstract In a hunt for Th2-bias regulatory loci in mice, we have used interval-specific congenic mapping to positionally clone a gene called Mina, encoding an immunoregulatory member of the JmjC protein family. Th2-bias is a genetic trait defined as the propensity of naïve T helper cells to develop in vitro under neutral conditions into T helper 2 (Th2) effector cells. Th2 cells play a critical role in host protection from multicellular parasites such as intestinal helminths and when disregulated contribute to allergic diseases such as asthma. The Th2-bias trait is known to vary across differ
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39

Drake, C. G., S. J. Rozzo, H. F. Hirschfeld, N. P. Smarnworawong, E. Palmer, and B. L. Kotzin. "Analysis of the New Zealand Black contribution to lupus-like renal disease. Multiple genes that operate in a threshold manner." Journal of Immunology 154, no. 5 (1995): 2441–47. http://dx.doi.org/10.4049/jimmunol.154.5.2441.

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Abstract F1 progeny of New Zealand Black (NZB) and New Zealand White (NZW) mice spontaneously develop an autoimmune process remarkably similar to human systemic lupus erythematosus. Previous studies have implicated major genetic contributions from the NZW MHC and from a dominant NZB gene on chromosome 4. To identify additional NZB contributions to lupus-like disease, (NZB x SM/J)F1 x NZW backcross mice were followed for the development of severe renal disease and were comprehensively genotyped. Despite a 50% incidence of disease, significant associations between the presence of the NZB genotyp
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40

Seda, Ondrej, Ludmila Kazdova, Drahomira Krenova, and Vladimir Kren. "Rosiglitazone fails to improve hypertriglyceridemia and glucose tolerance in CD36-deficient BN.SHR4 congenic rat strain." Physiological Genomics 12, no. 2 (2003): 73–78. http://dx.doi.org/10.1152/physiolgenomics.00113.2002.

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The favorable metabolic effects of thiazolidinediones are supposedly related to the peroxisome proliferator-activated receptor-γ (PPARγ)-driven changes in lipid metabolism, particularly in free fatty acid (FFA) trafficking. The fatty acid translocase CD36 is one of the proposed PPARγ targets to mediate this action. We assessed the effect of rosiglitazone (RSG, Avandia) administration in two inbred rat strains, BN/Cub and BN.SHR4 congenic strain, differing in 10 cM proximal segment of chromosome 4. Rats were fed high-sucrose diet with or without RSG for 1 wk. In BN.SHR4, which carries defective
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41

Zeid, Dana, Sean Mooney-Leber, Laurel R. Seemiller, Lisa R. Goldberg, and Thomas J. Gould. "Terc Gene Cluster Variants Predict Liver Telomere Length in Mice." Cells 10, no. 10 (2021): 2623. http://dx.doi.org/10.3390/cells10102623.

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Variants in a gene cluster upstream-adjacent to TERC on human chromosome 3, which includes genes APRM, LRRC31, LRRC34 and MYNN, have been associated with telomere length in several human populations. Currently, the mechanism by which variants in the TERC gene cluster influence telomere length in humans is unknown. Given the proximity between the TERC gene cluster and TERC (~0.05 Mb) in humans, it is speculated that cluster variants are in linkage disequilibrium with a TERC causal variant. In mice, the Terc gene/Terc gene cluster are also located on chromosome 3; however, the Terc gene cluster
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42

Benoit, Vivian M., Annett Petrich, Kishore R. Alugupalli, et al. "Genetic Control of the Innate Immune Response to Borrelia hermsii Influences the Course of Relapsing Fever in Inbred Strains of Mice." Infection and Immunity 78, no. 2 (2009): 586–94. http://dx.doi.org/10.1128/iai.01216-09.

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ABSTRACT Host susceptibility to infection is controlled in large measure by the genetic makeup of the host. Spirochetes of the genus Borrelia include nearly 40 species of vector-borne spirochetes that are capable of infecting a wide range of mammalian hosts, causing Lyme disease and relapsing fever. Relapsing fever is associated with high-level bacteremia, as well as hematologic manifestations, such as thrombocytopenia (i.e., low platelet numbers) and anemia. To facilitate studies of genetic control of susceptibility to Borrelia hermsii infection, we performed a systematic analysis of the cour
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43

Cho, Hye-Youn, Anne E. Jedlicka, Robert Clarke, and Steven R. Kleeberger. "Role of Toll-like receptor-4 in genetic susceptibility to lung injury induced by residual oil fly ash." Physiological Genomics 22, no. 1 (2005): 108–17. http://dx.doi.org/10.1152/physiolgenomics.00037.2005.

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The mechanisms of susceptibility to particle-induced lung injury are not clearly understood. To evaluate the contribution of genetic background to pulmonary pathogenesis, we compared the lung injury responses to residual oil fly ash (ROFA) in inbred mouse strains and calculated heritability estimates. Significant interstrain (genetic) variation was observed in ROFA-induced lung inflammation and hyperpermeability phenotypes; broad-sense heritability ranged from ∼0.43 to 0.62, and the coefficient of genetic determination ranged from 0.28 to 0.45. C3H/HeJ (HeJ) mice were most resistant to the ROF
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44

Soutiere, Shawn E., and Wayne Mitzner. "Comparison of postnatal lung growth and development between C3H/HeJ and C57BL/6J mice." Journal of Applied Physiology 100, no. 5 (2006): 1577–83. http://dx.doi.org/10.1152/japplphysiol.00809.2005.

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Previous work by our group has demonstrated substantial differences in lung volume and morphometric parameters between inbred mice. Specifically, adult C3H/HeJ (C3) have a 50% larger lung volume and 30% greater mean linear intercept than C57BL/6J (B6) mice. Although much of lung development occurs postnatally in rodents, it is uncertain at what age the differences between these strains become manifest. In this study, we performed quasi-static pressure-volume curves and morphometric analysis on neonatal mice. Lungs from anesthetized mice were degassed in vivo using absorption of 100% O2. Pressu
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45

Alaro, James R., Andrea Partridge, Kazutoyo Miura, et al. "A Chimeric Plasmodium falciparum Merozoite Surface Protein Vaccine Induces High Titers of Parasite Growth Inhibitory Antibodies." Infection and Immunity 81, no. 10 (2013): 3843–54. http://dx.doi.org/10.1128/iai.00522-13.

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ABSTRACTThe C-terminal 19-kDa domain ofPlasmodium falciparummerozoite surface protein 1 (PfMSP119) is an established target of protective antibodies. However, clinical trials ofPfMSP142, a leading blood-stage vaccine candidate which contains the protective epitopes ofPfMSP119, revealed suboptimal immunogenicity and efficacy. Based on proof-of-concept studies in thePlasmodium yoeliimurine model, we produced a chimeric vaccine antigen containing recombinantPfMSP119(rPfMSP119) fused to the N terminus ofP. falciparummerozoite surface protein 8 that lacked its low-complexity Asn/Asp-rich domain, rP
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46

Kiely, P. D., I. Pecht, and D. B. Oliveira. "Mercuric chloride-induced vasculitis in the Brown Norway rat: alpha beta T cell-dependent and -independent phases: role of the mast cell." Journal of Immunology 159, no. 10 (1997): 5100–5106. http://dx.doi.org/10.4049/jimmunol.159.10.5100.

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Abstract Mercuric chloride induces a necrotizing vasculitis in the Brown Norway (BN) rat. This occurs in two phases, between 1 and 5 days (early) and between 12 and 20 days (late) after initiation of HgCl2. One outbred and four inbred rat strains were found to be susceptible to early vasculitis, but only the BN strain developed late vasculitis. In the BN strain, treatment with the mAb R73 (anti-alpha beta TCR) inhibited T cell function, completely prevented the late vasculitis, but had no effect against early vasculitis, indicating that early and late vasculitis is controlled by different gene
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47

Biddle, Fred G., James R. Eisner, and Brenda A. Eales. "The testis-determining autosomal trait, Tda-1, of C57BL/6J is determined by more than a single autosomal gene when compared with DBA/2J mice." Genome 37, no. 2 (1994): 296–304. http://dx.doi.org/10.1139/g94-041.

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The putative Tda-1 or testis-determining autosomal trait of the C57BL/6J mouse strain came to attention when the Y chromosome from the poschiavinus variety of Mus musculus domesticus was introduced into C57BL/6J by backcross matings. The F1 generation expressed normal testis development in XY individuals with the poschiavinus Y chromosome. In the backcross and subsequent crosses to C57BL/6J females, XY individuals expressed ovaries bilaterally or various combinations of an ovotestis with a contralateral ovary or testis or bilateral ovotestes and a few had testes bilaterally. Some of the previo
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48

Mims, C. W., and L. J. Vaillancourt. "Ultrastructural Characterization of Infection and Colonization of Maize Leaves by Colletotrichum graminicola, and by a C. graminicola Pathogenicity Mutant." Phytopathology® 92, no. 7 (2002): 803–12. http://dx.doi.org/10.1094/phyto.2002.92.7.803.

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Observations were made of the ultrastructure of infection and colonization of leaves of a susceptible maize inbred by Colletotrichum graminicola and by a C. graminicola pathogenicity mutant. The mutant causes no symptoms on either maize leaves or stalks. Prior evidence suggested that it is deficient in production of signal peptidase, responsible for cleavage of signal peptides from proteins destined for transport through the endoplasmic reticulum. There was no significant difference in the process of infection or colonization by the mutant and wild-type strains up to 48 h after inoculation. Bo
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49

Ashraf, Muhammad Z., and Rashid Ahmad. "Some New Construction of Diallel Crosses." International Journal of Social Studies 4, no. 1 (2024): 019–27. https://doi.org/10.55627/ijss.004.01.01295.

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One of the fundamental goals of crop genetics research is the development of improved crop varieties through the analysis of genetic architecture, particularly when multiple crop strains are involved. Diallel cross experiments, involving the crossing of various inbred parental lines, are commonly used to evaluate these lines' combining ability and identify superior genetic combinations. This study focuses on constructing and applying Balanced Incomplete Block Designs (BIBDs) and Partial Diallel Cross (PDC) designs to optimize genetic evaluation strategies. BIBDs constructed using the method of
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50

Sayles, P. C., and D. L. Wassom. "Immunoregulation in murine malaria. Susceptibility of inbred mice to infection with Plasmodium yoelii depends on the dynamic interplay of host and parasite genes." Journal of Immunology 141, no. 1 (1988): 241–48. http://dx.doi.org/10.4049/jimmunol.141.1.241.

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Abstract Inbred and H-2 congenic mouse strains were tested for their ability to resist infections with the non-lethal 17X or with the lethal YM isolates of Plasmodium yoelii. DBA/2 and B10.D2 mice, which best resisted infections with non-lethal P. yoelii, were exquisitely susceptible to infection with lethal isolates of this malaria species. In contrast, B6 and B10 mice, which were susceptible to infection with non-lethal P. yoelii, were resistant to infection with the lethal isolates. This reversal of host response phenotype was influenced by H-2 genes, as evidenced by the divergent responses
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