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Journal articles on the topic 'Individual dose criterion'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Repin, V. S., and L. V. Repin. "CRITERIA FOR THE PROTECTING OF POPULATION AFTER RADIATION ACCIDENT: USE OF RADIATION RISK FOR ANALYSIS AND OPTIMAL DECISIONS MAKING TO LIMIT THE CONSUMPTION OF FOOD CONTAMINATED BY TECHNOGENIC RADIONUCLIDES." Radiatsionnaya Gygiena = Radiation Hygiene 11, no. 4 (2018): 28–38. http://dx.doi.org/10.21514/1998-426x-2018-11-4-28-38.

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The purpose of this paper is to assess the compliance of criterion A, adopted in NRB-99/2009 as emergency level of dose intervention, to permissible values of specific activity of137Cs,90Sr and131I in food products in the first year after the accident. Assessments are made on the basis of comparison of the conservativeness coefficients by dose and the magnitude of the risk. The results of the evaluation showed that estimates of the doses and risks for137Cs,90Sr, calculated on the basis of weighting by the number of age groups, are equally conservative. For131I, the conservative factors for dos

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Zhuchenko, Yu M. "THE GENERAL ESTIMATION OF EFFICIENCY OF THE LONG-TERM ANTIRADIATION AGRICULTURAL MEASURES TAKEN DURING THE POSTCHERNOBYL PERIOD IN BELARUS." Health and Ecology Issues, no. 2 (June 28, 2015): 81–86. http://dx.doi.org/10.51523/2708-6011.2015-12-2-17.

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We have estimated the efficiency of agricultural measures by the criterion of the individual total effective accumulated dose per average resident of the polluted areas of Belarus during the Post-Chernobyl period. We have calculated the share contribution of each of the three factors (physical half-life decay period, biogeochemical processes, counter-measures) in decreased radioactivity of milk being the main dose-forming factor. The annual effective doses of internal, external and total irradiation and their dynamics over 1987-2012 for mineral and peaty soils have been estimated.

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Dashanova, E., A. Molokanov, and E. Korneva. "Justification and Application of Sufficiency Criterion for Measuring the Activity of Uranium Radioisotopes in Biological Samples." Medical Radiology and radiation safety 66, no. 4 (2021): 70–76. http://dx.doi.org/10.12737/1024-6177-2021-66-4-70-76.

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Purpose: Ensuring the fulfillment of the sufficiency n criterion when measuring the activity of uranium radionuclides in biological samples carried out within the individual monitoring programme by calculation of the uncertainty and characteristics limits for measurements. Material and methods: The sufficiency criterion definition is given, which determines the maximum value of the decision threshold for measurements carried out for the individual monitoring of workers at which the fact of non-exceeding of the annual dose limit or permissible level takes place, taking into account the un

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Yuan, Jiankui, Yiran Zheng, Barry Wessels, et al. "Experimental Validation of Monte Carlo Simulations Based on a Virtual Source Model for TomoTherapy in a RANDO Phantom." Technology in Cancer Research & Treatment 15, no. 6 (2016): 796–804. http://dx.doi.org/10.1177/1533034615605007.

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A virtual source model for Monte Carlo simulations of helical TomoTherapy has been developed previously by the authors. The purpose of this work is to perform experiments in an anthropomorphic (RANDO) phantom with the same order of complexity as in clinical treatments to validate the virtual source model to be used for quality assurance secondary check on TomoTherapy patient planning dose. Helical TomoTherapy involves complex delivery pattern with irregular beam apertures and couch movement during irradiation. Monte Carlo simulation, as the most accurate dose algorithm, is desirable in radiati

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Wagner, de Souza Pereira, Kelecom Alphonse, Vivente Bento Macedo Marcos, Santos Araujo Rosane, Martinelli Fabbri Júlia, and Silva Gomes Santos Dulcinea. "Analysis of Lead-210 in Surface Water nearby a Phosphate Mining at Semi-arid Region in Santa Quitéria, Ceará State, Brazil." Advances in Research 9, no. 6 (2017): 1–8. https://doi.org/10.9734/AIR/2017/33213.

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<strong>Aims:</strong> To report the activity concentrations (AC) of <sup>210</sup>Pb in surface waters in a semi-arid region, aiming to record these concentrations before the beginning of a Naturally Occurring Radioactive Material (NORM) mining operation, facilitating subsequent comparisons with the operational phase besides verifying the radioecological characteristics of this radionuclide and the potability of the water used for human consumption by the local population. <strong>Study Design: </strong>The water samples were collected in a six points grid associated to places of human consum

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Geleva, Elena, Svetoslav Dimitrov, Nikolay Goutev, Verzhinia Variyska, and Dimitar Tonev. "GROSS ALPHA AND BETA ACTIVITY IN MINERAL WATER FROM SOUTHWEST BULGARIA." Ecological Engineering and Environment Protection 2023, no. 1/2023 (2023): 77–82. http://dx.doi.org/10.32006/eeep.2023.1.7782.

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The natural radioactivity levels of mineral water from certain most frequently used sources in Southwest Bulgaria were determined. The mineral water was investigated with regard to gross alpha and beta activity to determine whether the activity concentrations are below levels at which no further action is required. The measurements were made by Liquid Scintillation Spectrometer. The gross alpha and beta activity varied from ≤ 0.003 Bq/L to 0.671 Bq/L and from 0.054 and to 0.375 Bq/L, respectively. The values obtained in this study were compared with data reported by other authors in different

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Herger, Simon, Werner Vach, Anna-Maria Liphardt, Corina Nüesch, Christian Egloff, and Annegret Mündermann. "Experimental-analytical approach to assessing mechanosensitive cartilage blood marker kinetics in healthy adults: dose-response relationship and interrelationship of nine candidate markers." F1000Research 10 (June 22, 2021): 490. http://dx.doi.org/10.12688/f1000research.52159.1.

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Purpose: To determine the suitability of selected blood biomarkers of articular cartilage as mechanosensitive markers and to investigate the dose-response relationship between ambulatory load magnitude and marker kinetics in response to load. Methods: Serum samples were collected from 24 healthy volunteers before and at three time points after a 30-minute walking stress test performed on three test days. In each experimental session, one of three ambulatory loads was applied: 100% body weight (BW); 80%BW; 120%BW. Serum concentrations of COMP, MMP-3, MMP-9, ADAMTS-4, PRG-4, CPII, C2C and IL-6 w

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Herger, Simon, Werner Vach, Anna-Maria Liphardt, Corina Nüesch, Christian Egloff, and Annegret Mündermann. "Experimental-analytical approach to assessing mechanosensitive cartilage blood marker kinetics in healthy adults: dose-response relationship and interrelationship of nine candidate markers." F1000Research 10 (January 11, 2022): 490. http://dx.doi.org/10.12688/f1000research.52159.2.

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Purpose: To determine the suitability of selected blood biomarkers of articular cartilage as mechanosensitive markers and to investigate the dose-response relationship between ambulatory load magnitude and marker kinetics in response to load. Methods: Serum samples were collected from 24 healthy volunteers before and at three time points after a 30-minute walking stress test performed on three test days. In each experimental session, one of three ambulatory loads was applied: 100% body weight (BW); 80%BW; 120%BW. Serum concentrations of COMP, MMP-3, MMP-9, ADAMTS-4, PRG-4, CPII, C2C and IL-6 w

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Gebremedhn, Endale G., Peter J. Shortland, and David A. Mahns. "Variability of Oxaliplatin-Induced Neuropathic Pain Symptoms in Each Cycle and Its Implications on the Management of Colorectal Cancer Patients: A Retrospective Study in South Western Sydney Local Health District Hospitals, Sydney, Australia." Journal of Oncology 2019 (August 1, 2019): 1–11. http://dx.doi.org/10.1155/2019/4828563.

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Oxaliplatin-induced neuropathic pain limits treatment compliance. However, the variability of neuropathic pain symptoms in each cycle for individual patients and the impacts on treatment compliance remain untested. Data from 322 adult patients who received oxaliplatin-based chemotherapy were extracted based on pattern of chemotherapy, adverse events, and patient survival. Cox regression and survival analyses were employed. Seventy-eight percent of patients developed neuropathic pain that oscillated between a complete absence and presence on a cycle-by-cycle basis. Consequently, the presence of

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Mizutani, Takuya, Taiki Magome, Hiroshi Igaki, et al. "Optimization of treatment strategy by using a machine learning model to predict survival time of patients with malignant glioma after radiotherapy." Journal of Radiation Research 60, no. 6 (2019): 818–24. http://dx.doi.org/10.1093/jrr/rrz066.

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ABSTRACT The purpose of this study was to predict the survival time of patients with malignant glioma after radiotherapy with high accuracy by considering additional clinical factors and optimize the prescription dose and treatment duration for individual patient by using a machine learning model. A total of 35 patients with malignant glioma were included in this study. The candidate features included 12 clinical features and 192 dose–volume histogram (DVH) features. The appropriate input features and parameters of the support vector machine (SVM) were selected using the genetic algorithm base

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Jacobsen, Paula L., Atul R. Mahableshwarkar, William A. Palo, Yinzhong Chen, Marianne Dragheim, and Anita H. Clayton. "Treatment-emergent sexual dysfunction in randomized trials of vortioxetine for major depressive disorder or generalized anxiety disorder: a pooled analysis." CNS Spectrums 21, no. 5 (2015): 367–78. http://dx.doi.org/10.1017/s1092852915000553.

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ObjectiveAntidepressants are frequently associated with treatment-emergent sexual dysfunction (TESD). Vortioxetine, which was approved for patients with major depressive disorder (MDD), has a receptor profile that suggests limited impact on sexual functioning.MethodsArizona Sexual Experiences Scale (ASEX) patient-level data were pooled from 7 short-term vortioxetine trials (6 in MDD, 1 in generalized anxiety disorder) and analyzed for incidence of TESD at any post-baseline visit in patients without sexual dysfunction at baseline (defined as ASEX total score ≥19; individual ASEX item score ≥5;

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Semenov, O., and M. Lysychenko. "Ultraviolet installation for irradiation of animals with automatic control." Energy and automation, no. 6(52) (November 25, 2020): 128–38. http://dx.doi.org/10.31548/energiya2020.06.128.

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Modern technologies for the production of livestock products provide for long-term keeping of young animals indoors with an artificial microclimate. That is, it is expected to maintain within the required limits of temperature, humidity, gassiness, lighting level, etc. In particular, to compensate for solar radiation, ultraviolet irradiation units are used. The main criterion of UV irradiation is the dose, which is individual for each species and age of animals. The obtained amount of irradiation depends on the type and power of the radiation source, the height of the suspension, the continuan

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Smith, Patrick F., Abayomi Ogundele, Alan Forrest, et al. "Phase I and II Study of the Safety, Virologic Effect, and Pharmacokinetics/Pharmacodynamics of Single-Dose 3-O-(3′,3′-Dimethylsuccinyl)Betulinic Acid (Bevirimat) against Human Immunodeficiency Virus Infection." Antimicrobial Agents and Chemotherapy 51, no. 10 (2007): 3574–81. http://dx.doi.org/10.1128/aac.00152-07.

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ABSTRACT Bevirimat [3-O-(3′,3′-dimethylsuccinyl)betulinic acid] is the first in a new class of anti-human immunodeficiency virus (HIV) drugs that inhibit viral maturation by specifically blocking cleavage of the Gag capsid (CA) precursor, CA-SP1, to mature CA protein, resulting in defective core condensation and release of immature noninfectious virions. Four cohorts of six HIV-infected adults, with CD4 counts of >200 and plasma viral loads of 5,000 to 250,000 transcripts/ml and not currently receiving antiretroviral therapy, were randomized to receive a single oral dose of placebo, 75, 150

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Sukhikh, E., L. Sukhikh, A. Vertinsky, P. Izhevsky, I. Sheino, and V. Vertoukhova. "Analysis of the Physical and Radiobiological Equivalence of the Calculated and Measured Dose Distributions for Prostate Stereotactic Radiotherapy." Medical Radiology and radiation safety 66, no. 3 (2021): 68–75. http://dx.doi.org/10.12737/1024-6177-2021-66-3-68-75.

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Purpose: Carrying out the analysis of the physical and radiobiological equivalence of dose distributions obtained during the planning of hypofractionated stereotactic radiation therapy of the prostate cancer and verification using a three-dimensional cylindrical dosimeter. Material and Methods: Based on the anatomical data of twelve patients diagnosed with prostate carcinoma, stage T2N0M0 with low risk, plans were developed for stereotactic radiation therapy with volumetric modulates arc therapy (VMAT). The dose per fraction was 7,25 Gy for 5 fractions (total dose 36,25 Gy) with a normal

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Al-Sudani, Zahraa A. Ismail, Sawsan S. Fleifil, and Mazin Mohammed. "Measurement of Tritium Activity Concentrations in Water Samples of Al-Amara City in Misan Province-Iraq, using Liquid Scintillation Counter." Asian Journal of Water, Environment and Pollution 20, no. 1 (2023): 67–75. http://dx.doi.org/10.3233/ajw230010.

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This research work aims to measure the concentration of tritium activity in the Tigris river and samples of tap water collected from different places of Al-Amara city in Misan province using a Tri-Carb 3110TR liquid scintillation counter (LSC) and to calculate an annual effective dose due to the ingestion of water samples. The mean values of the tritium activity concentrations measured in the water samples were 0.562 ± 0.126 Bq/L (4.763 ± 1.075TU) and 0.521 ± 0.060 Bq/L (4.422 ± 0.512TU) for Tigris River and tap water samples, respectively. The mean annual effective doses are given to the infa

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Los, Maartje, Frank L. Gerritse, Hielke Jodie Meulenbeld, Jeanine M. L. Roodhart, Ankie M. T. van der Velden, and Ronald De Wit. "Analysis of docetaxel therapy in elderly (≥70yrs) castration resistant prostate cancer (CRPC) patients enrolled in the Netherlands Prostate Study (NePro)." Journal of Clinical Oncology 31, no. 15_suppl (2013): e16059-e16059. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e16059.

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e16059 Background: Prostate cancer truly is an age-associated disease, approximately half of prostate cancer patients in the Netherlands are aged 70 years or older at the time of diagnosis. However, age above 70 years has been an exclusion criterion in many clinical trials. Hence the knowledge about chemotherapy tolerance and toxicity in patients aged 70 years and above is limited. In this study we evaluated the influence of age on docetaxel chemotherapy in elderly (≥70yrs) castration resistant prostate cancer (CRPC) patients. Methods: Prostate cancer truly is an age-associated disease, approx

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Kurabekova, R. M., O. M. Tsirulnikova, O. E. Gichkun, et al. "Correlation between insulin-like growth factor 1 levels and tacrolimus dose in pediatric liver recipients." Russian Journal of Transplantology and Artificial Organs 23, no. 2 (2021): 13–20. http://dx.doi.org/10.15825/1995-1191-2021-2-13-20.

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Introduction. To prevent post-transplant complications associated with unbalanced immunosuppression, objective indicators reflecting the state of the immune system and associated with the immunosuppressant dose are required. In pediatric liver transplantation, an important indicator of hepatocellular function and restoration of anthropometric characteristics is insulin-like growth factor 1 (IGF-1), which exhibits both nonspecific and selective immunomodulator properties.Objective: to assess the correlation between growth hormone and IGF-1 levels and tacrolimus dose and blood concentrations in

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Balakin, V., V. Mashinistov, and A. Koveria. "Perspective technology of recycling of radioactive contaminated metal based on its melting." Nuclear and Radiation Safety, no. 2(78) (June 7, 2018): 43–48. http://dx.doi.org/10.32918/nrs.2018.2(78).07.

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Melting of the radioactively contaminated metal converts it as a source of ionizing radiation from a surface distribution of radionuclides into the source with their volume distribution. From the surface of the melted metal gamma radiation of a part of radionuclides is emitted, which are in its scope. Alpha and beta radiation are absorbed completely in the metal. To obtain a radiation-safe metal it is necessary that the amount of gamma-emitting radionuclides, which are loaded into the furnace together with the charge, did not exceed the established allowable level. The radiation sa

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Bushnell, Philip J. "Styrene Impairs Serial Spatial Reversal Learning in Rats." Journal of the American College of Toxicology 13, no. 4 (1994): 279–300. http://dx.doi.org/10.3109/10915819409140600.

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To evaluate the effects of styrene exposure on learning, adult male Long-Evans rats learned repeated reversals of a spatial discrimination task. Styrene monomer (50% vol/vol in corn oil) was administered by gavage to groups of eight rats at 500 mg/kg/day, 5 days/week, for 8 weeks in Experiments (Exps) I and II (total dose = 20.0 g/kg) or for 1,3,5, or 8 weeks in Exp III (total dose = 2.5, 7.5, 12.5, or 20.0 g/kg). Control rats received corn oil vehicle for 8 weeks. Reversal training began 8 (Exp I), 10 (Exp II), or 32 (Exp III) weeks after termination of dosing. In Exp I, an instrumental (IN)

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Bradbury, P. A., P. Twumasi-Ankrah, K. Ding, et al. "The impact of brain metastases on overall survival (OS) in National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) clinical trials (CT) in advanced non-small cell lung cancer (NSCLC)." Journal of Clinical Oncology 27, no. 15_suppl (2009): 8075. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.8075.

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8075 Background: NSCLC patients (pts) with brain metastases (BMet) commonly are excluded from participating in clinical trials (CTs), based on perceptions of inferior outcomes. We evaluated the validity of this exclusion criterion, by investigating the OS of stage IV NSCLC pts with (BMet) and without (non-BMet) a prior history of BMet recruited to NCIC CTG CTs. Methods: This pooled analysis utilized data from BR.18 (paclitaxel/ carboplatin [PC] ± MMPI [BMS275291]), BR.21 (erlotinib vs. placebo), BR.24 (PC± VEGFR TKI [AZD2171]). Each trial permitted entry of pts with neurologically stable BMet,

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Finashov, L. V., V. V. Vostrotin, and A. Yu Yanov. "Tririum in urine in residents of Ozyorsk, the Chelyabinsk region in 2016." Radiatsionnaya Gygiena = Radiation Hygiene 12, no. 3 (2019): 42–49. http://dx.doi.org/10.21514/1998-426x-2019-12-3-42-49.

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Objectives. To create the model of relation between volume activity of tritium in urine of Ozyorsk residents and physical and biological factors. To define the correspondence of internal exposure doses of Ozyorsk residents obtained from tritium to standards and requirements of present-day radiation security system. In the framework of the objectives the following tasks were solved: measurement of volume activity of tritium in the urine; detection of main factors affecting the volume activity of tritium in the urine; estimation of the distribution of committed effective dose equivalent of inter

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Gjini, Erida, Francisco F. S. Paupério, and Vitaly V. Ganusov. "Treatment timing shifts the benefits of short and long antibiotic treatment over infection." Evolution, Medicine, and Public Health 2020, no. 1 (2020): 249–63. http://dx.doi.org/10.1093/emph/eoaa033.

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Abstract Antibiotics are the major tool for treating bacterial infections. Rising antibiotic resistance, however, calls for a better use of antibiotics. While classical recommendations favor long and aggressive treatments, more recent clinical trials advocate for moderate regimens. In this debate, two axes of ‘aggression’ have typically been conflated: treatment intensity (dose) and treatment duration. The third dimension of treatment timing along each individual’s infection course has rarely been addressed. By using a generic mathematical model of bacterial infection controlled by immune resp

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Chegrynets, A. I., О. О. Saliy, I. A. Sobko, and V. O. Krasinko. "Immunological evaluation of inactivated Newcastle disease vaccine depending on adjuvant composition." Regulatory Mechanisms in Biosystems 12, no. 3 (2021): 490–97. http://dx.doi.org/10.15421/022167.

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Newcastle disease is a global problem that is being recorded in most countries and also a serious obstacle to exchange of genetic material of poultry in various countries of the world. Control of the Newcastle disease comprises correct injection of efficacious vaccines so as to decrease or eliminate the clinical disease. Our goal was to perform comparative studies of the vaccines against Newcastle disease of water in oil type, the adjuvant being mineral oil mixed with emulsifiers (Span-80 and Tween-80) and ready-to-use adjuvant system (Montanide ISA 70), and study the impact of composition of

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Smith, Allan H., and Dan S. Sharp. "A Standardized Benchmark Approach To the Use of Cancer Epidemiology Data for Risk Assessment." Toxicology and Industrial Health 1, no. 4 (1985): 205–12. http://dx.doi.org/10.1177/074823378500100413.

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Clarity and scientific validity are two criteria for assessing the quality of communications between scientists and risk managers. Regulating permissible exposures on the basis of very-low-dose risk extrapolation uses scientific information that may not meet either criterion. With regard to clarity, it is difficult for an individual to conceive of the meaning of risks on the order of 1 in 1,000,000 lifetime excess. With regard to scientific validity, the uncertainties of extrapolating risks at very low doses are evident in the wide variation in results produced depending on the statistical and

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Ozsahin, Dilber Uzun, Mehmet Ilker Gelisen, Mustapha Taiwo, Yasemin Agachan, Dorrin Rahi, and Berna Uzun. "Decision Analysis of the COVID-19 Vaccines." EuroBiotech Journal 5, s1 (2021): 20–25. http://dx.doi.org/10.2478/ebtj-2021-0017.

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Abstract The entire globe is struggling with the COVID-19 pandemic since March 11, 2020. There is still a large number of infected patients and death, and there is no proven treatment for the infection yet. This has led to the race in vaccine development to protect people from COVID-19 infection. As of February 3, 2021, there were 289 experimental COVID -19 vaccines in development, 66 of which were in clinical trials with different phases, and 20 of them were in phase 3. This study aims to evaluate 15 important vaccines based on criteria such as the dose number, dosing schedule, storage advant

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Kennedy, Robert S., Janet J. Turnage, and William P. Dunlap. "Diagnosis of Alcohol Intoxication: Effectiveness of Cognitive and Neurovestibular Field Sobriety Tests." Proceedings of the Human Factors and Ergonomics Society Annual Meeting 37, no. 14 (1993): 964–68. http://dx.doi.org/10.1177/154193129303701407.

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Tests from an automated performance test battery of cognitive tests and the standardized field sobriety tests (FST) used nationwide by law enforcement officers were administered in three experiments involving graded dosages of alcohol. In the first experiment, subjects were raised to one of four levels of alcohol dosage in four different sessions. In the second experiment, the descending branch of the blood alcohol level (BAL) curve was monitored from .15 BAL, and cognitive and motor performances were assessed by the Automated Performance Test System (APTS) and FST. In the third experiment, th

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Agarwal, Neeraj, Kinjal Parikh, Srinivas Kiran Tantravahi, et al. "Clinical benefit (CB) of high-dose interleukin-2 (HD IL-2) in clear cell (cc) metastatic renal cell carcinoma (mRCC)." Journal of Clinical Oncology 32, no. 4_suppl (2014): 461. http://dx.doi.org/10.1200/jco.2014.32.4_suppl.461.

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461 Background: HD IL-2, an immunotherapy, is a standard of care for a select group of patients (pts) with mRCC. Generally objective response (OR) rates, i.e. complete response (CR) + partial response (PR), of 16-20% are discussed with pts, but not disease stabilization (SD). Recent data suggest that cancer immunotherapy may improve survival without inducing OR. Thus, treatment with HD IL-2 may provide survival benefit to an additional group of pts not experiencing OR, but only SD as the best response. Here we report CB ( OR+SD), and specifically report outcomes of cc mRCC pts experiencing SD

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Gisslinger, Heinz, Christoph Klade, Pencho Georgiev, et al. "Individualized Dosing of Ropeginterferon Alfa-2b Ensures Optimal Response in Patients with Low-Risk Polycythemia Vera (PV)." Blood 142, Supplement 1 (2023): 4563. http://dx.doi.org/10.1182/blood-2023-173499.

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Introduction: Ropeginterferon alfa-2b at a fixed dose of 100 µg/2 weeks was efficacious in patients with low-risk polycythemia vera (PV) in the Low-PV trial, but the response rate was lower in a group of patients who switched to ropeginterferon alfa-2b after failing to respond to phlebotomy alone (Barbui et al., 2023). The finding that this group had a higher proportion of males and higher baseline values for body-mass index, phlebotomy demand, blood counts and JAK2V617F allele burden suggests that these characteristics might predict a higher dose requirement of ropeginterferon alfa-2b. We ana

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Martusevich, Andrew Kimovich. "use of methods of the biocrystallomics in personification of the treatment with high diluted drugs." International Journal of High Dilution Research - ISSN 1982-6206 17, no. 2 (2021): 33. http://dx.doi.org/10.51910/ijhdr.v17i2.938.

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Background: One of most important trends in modern medicine is its transformation to personalized diagnostics and treatment. This tendency fully applies to homeopathy, especially considering that this discipline is based on the principles of individual approach to the patient. At the same time, the methods of individualization of treatment in homeopathy are relatively few.  Aims: Develop of methodology and methods of application biocrystalloscopic tests to personalize the homeopathic treatment. The proposed technology became previously proposed for ozone therapy practice as biocrystallom

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Labbe, Vincent, Damien Contou, Nicholas Heming, et al. "Comparison of standard prophylactic, intermediate prophylactic and therapeutic anticoagulation in patients with severe COVID-19: protocol for the ANTICOVID multicentre, parallel-group, open-label, randomised controlled trial." BMJ Open 12, no. 4 (2022): e059383. http://dx.doi.org/10.1136/bmjopen-2021-059383.

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IntroductionCOVID-19 induces venous, arterial and microvascular thrombosis, involving several pathophysiological processes. In patients with severe COVID-19 without macrovascular thrombosis, escalating into high-dose prophylactic anticoagulation (HD-PA) or therapeutic anticoagulation (TA) could be beneficial in limiting the extension of microvascular thrombosis and forestalling the evolution of lung and multiorgan microcirculatory dysfunction. In the absence of data from randomised trials, clinical practice varies widely.Methods and analysisThis is a French multicentre, parallel-group, open-la

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E, Lukin, Mashinistov V, Galkin O, and Muzychenko A. "Radiation protection of melting of radioactive contaminated metal." Theory and practice of metallurgy 1, no. 1 (2019): 62–70. http://dx.doi.org/10.34185/tpm.1.2019.08.

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An integral component of modern technogenic activities using nuclear energy is the accumulation of radioactively contaminated metals. Solving the issues of recycling or returning these metals to reuse is inextricably linked to ensuring the radiation safety of people and the environment at all stages of the technological cycle using radioactive metal. Possible consequences of the effect of ionizing radiation on the human body are considered, the features of radioactively contaminated metal as a possible source of radiation for production personnel are investigated, as well as the analysis of ra

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Treshchalina, Yelena, Saida Karshieva, Natalya Anisimova, Suriya Sitdikova, and Mikhail Kiselevskiy. "ANTIINTEGRIN AVG3 SAV-RGD AS COMBINANT FOR DTIC WITH HUMAN AMELANOTIC SKIN MELANOMA." Problems in oncology 65, no. 2 (2019): 298–302. http://dx.doi.org/10.37469/0507-3758-2019-65-2-298-302.

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Introduction. The avB3 integrin (cell adhesion molecule) plays the role of the receptor, including, metalloproteinase matrix 2, involved in melanoma metastasis. We have been characterized as an antimelanoma original anti-integrin agent SAV-RGD (lyo-SAV-RGD), specifically binding to melanoma cells by means of the Arg-Gly-Asp tripeptide. More significant inhibited effect was obtained on amelanotic human skin melanoma MeWo. Accordingly, the experimental evaluation of the effectiveness of lyo-SAV-RGD in combination with the «gold» standard of antimelanoma chemotherapy dacarbazine (DTIC) is relevan

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Winchell, Gregory A., Rik de Greef, Rebecca E. Wrishko, Eric Mangin, Hetty Waskin, and Christopher Bruno. "1558. A Population Pharmacokinetic Model for Posaconazole Intravenous Solution and Oral Powder for Suspension Formulations in Pediatric Patients With Neutropenia." Open Forum Infectious Diseases 6, Supplement_2 (2019): S569. http://dx.doi.org/10.1093/ofid/ofz360.1422.

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Abstract Background Posaconazole is approved in adults for prophylaxis and treatment of invasive fungal disease. Two formulations that offer weight-based dosing—intravenous (IV) and oral powder for suspension (PFS)—are being evaluated in children. A population pharmacokinetic (popPK) approach was used to characterize and predict the PK exposure of posaconazole PFS and IV formulations in children to identify dosages associated with achieving a target PK of 1200 ng/mL as the mean Cavg and individual Cavg ≥500 ng/mL and <2500 ng/mL in ~90% of patients. Methods A popPK model was developed throu

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Mikhaylova, I. N., M. N. Stakheyeva, I. Zh Shubina, et al. "The immune system contributes to the effectiveness of vaccine therapy in patients with metastatic melanoma." Siberian journal of oncology 22, no. 2 (2023): 43–55. http://dx.doi.org/10.21294/1814-4861-2023-22-2-43-55.

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The aim of the study was to identify differences in the immune system parameters between metastatic melanoma patients who responded and did not respond to dendritic cell vaccination.Material and Methods. The study group included 20 patients with stage III–IV metastatic melanoma, who received vaccine therapy with dendritic cells (DC) in a prophylactic mode. The control groups included 13 patients who had symptoms of disease progression at the time of starting vaccine therapy, and 5 healthy donors. The DC-vaccine was prepared in the form of a suspension of the patient’s autologous dendritic cell

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Kunarsih, Endang, Hermansyah Hermansyah, and Rusmanto Rusmanto. "Usulan kriteria pemulangan pasien (patient release) kedokteran nuklir di Indonesia." Jurnal Pengawasan Tenaga Nuklir 1, no. 2 (2021): 38–46. http://dx.doi.org/10.53862/jupeten.v1i2.017.

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Nuclear medicine procedures are carried out by applying a radioactive substance to the patient’s body. Thus, the patient can be assumed to be a ‘radiation source’ and needs to follow special provisions so that his presence does not expose nearby individuals unnecessarily. Therefore, when the patient is released from the hospital, it must ensure that the patient’s radiation exposure does not expose the individuals in the vicinity. However, several related regulations have not regulated this in detail. In this paper, a study is carried out regarding the criteria considered in the release of nucl

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Okoya, Aderonke A., Adeniyi S. Oginni, and Olarike F. Awofisayo. "Natural radionuclides and ions concentrations in water and sediments around iron-smelting industry in Ikirun, Osun-State, Nigeria." Journal of Public Health and Diseases 4, no. 4 (2021): 38–46. http://dx.doi.org/10.31248/jphd2021.103.

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Natural radionuclides pose a threat to the environment, because of the radioactivity they undergo. Water is said to be the sink of all pollutants including radionuclides and water pollution is a serious challenge due to the direct link between the adequacy of good quality water and the state of public health. The concentrations of uranium-238, thorium-232 and potassium-40 and ions in the selected water bodies around Ikirun Iron-smelting Industry were determined in wet and dry seasons to highlight possible radioactive pollution from the iron-smelting emissions. The radionuclides were analyzed u

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Labbé, Vincent, Cyrielle Desnos, Sebastien Preau, et al. "Risk, rate or rhythm control for new onset supraventricular arrhythmia during septic shock: protocol for the CAFS multicentre, parallel-group, open-label trial." BMJ Open 15, no. 4 (2025): e090404. https://doi.org/10.1136/bmjopen-2024-090404.

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IntroductionNew-onset supraventricular arrhythmia (NOSVA) is the most common arrhythmia in patients with septic shock and is associated with haemodynamic alterations and increased mortality rates. With no data available from randomised trials, clinical practice for patient management varies widely. In this setting, rate control or rhythm control could be beneficial in limiting the duration of shock and preventing evolution to multiorgan dysfunction.Methods and analysisThe Control Atrial Fibrillation in Septic shock (CAFS) study is a binational (French and Belgium), multicentre, parallel-group,

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OSCAR, THOMAS P. "General Regression Neural Network and Monte Carlo Simulation Model for Survival and Growth of Salmonella on Raw Chicken Skin as a Function of Serotype, Temperature, and Time for Use in Risk Assessment†." Journal of Food Protection 72, no. 10 (2009): 2078–87. http://dx.doi.org/10.4315/0362-028x-72.10.2078.

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A general regression neural network (GRNN) and Monte Carlo simulation model for predicting survival and growth of Salmonella on raw chicken skin as a function of serotype (Typhimurium, Kentucky, and Hadar), temperature (5 to 50°C), and time (0 to 8 h) was developed. Poultry isolates of Salmonella with natural resistance to antibiotics were used to investigate and model survival and growth from a low initial dose (&lt;1 log) on raw chicken skin. Computer spreadsheet and spreadsheet add-in programs were used to develop and simulate a GRNN model. Model performance was evaluated by determining

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Mykhailova, L. L., and M. G. Buzynny. "Practical use of radiation parameters of drinking water quality: guidelines of international organizations and ukrainian experience." Environment & Health, no. 4 (97) (December 2020): 27–34. http://dx.doi.org/10.32402/dovkil2020.04.027.

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The analysis of the documents of the authoritative international organizations and scientific works was carried out from the point of view of the development of the strategy for ensuring the radiation quality of drinking water. The radiation parameters of the quality of drinking water, the interpretation of monitoring results by screening and recommended levels, the value of the individual dose criterion, as well as algorithms for establishing the frequency of monitoring of the radiation parameters of drinking water were considered. Objective: We analyzed the documents of reputable internation

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Gardner, Melissa, Sebastian Winter, Jorg Dietrich, et al. "NCOG-09. RADIATION INDUCED CEREBRAL VOLUME LOSS AND CEREBROVASCULAR DISEASE RISK IN SURVIVORS OF GRADE 2 AND 3 GLIOMAS." Neuro-Oncology 24, Supplement_7 (2022): vii198—vii199. http://dx.doi.org/10.1093/neuonc/noac209.762.

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Abstract INTRODUCTION Cranial irradiation with protons (PRT) as compared with photons (PHT) reduces radiation exposure to healthy brain tissue and may mitigate early- and late-delayed complications. Prior work in our group has demonstrated that PRT results in less brain atrophy over 2 years post-treatment as compared with PHT. It is unknown whether individual factors, such as cerebrovascular disease risk (CVDR; known to be important in post-RT brain changes), interacts with treatment type to affect brain volume change. METHODS Patients treated with PRT for grade 2 or 3 gliomas were meticulousl

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Churbakova, O. V., D. V. Pechkurov, V. G. Akimkin, and V. V. Makashova. "The effectiveness of various antiviral therapy regimens in children with chronic hepatitis B." Infekcionnye bolezni 21, no. 4 (2023): 26–33. http://dx.doi.org/10.20953/1729-9225-2023-4-26-33.

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Objective. To determine the effectiveness of various interferon therapy regimens in children with chronic hepatitis B (HBV). Patients and methods. The study included 126 children with HBV aged 3 to 17 years, who were treated in the pediatric infectious diseases department of the N.A.Semashko City Clinical Hospital in Samara. The diagnosis of HBV was confirmed by the detection of markers HBsAg, anti-cor IgM, HBeAg, anti-HBe. 88 (69.8%) patients with HBeAg(+) were registered, with HBeAg(‑) – 38 (30,2%). To exclude hepatitis D, total anti-HDVs were determined. Hepatitis B virus DNA was detected b

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Huzun, Dorin, Uliana Kostiv, Serhii Sazhyn, Alla Sazhyna, and Koliesnik Dmytro Koliesnik. "SOME ASPECTS OF PREDICTING THE SEVERITY OF VIRUS-INDUCED BRONCHIAL ASTHMA EXACERBATION IN CHILDREN DUE TO COVID-19 PANDEMIC." Ukrainian Scientific Medical Youth Journal 127, no. 4 (2021): 99–106. http://dx.doi.org/10.32345/usmyj.4(127).2021.99-106.

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bronchial asthma is an important medical and social issue directly affects the health of patients, their quality of life, and the direct and indirect economic costs associated with the disease are quite significant. Due to the pandemic caused by a new strain of coronavirus SARS-CoV-2, international and domestic regulations documents have updated the management of patients with asthma. In particular, there have been recommendations for remote visits to assess the patients’ complaints however physical analysis and objective examination are not available during such consultations. It can lead to

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Appiah-Kubi, Abena, Seethal A. Jacob, Matthew M. Heeney, et al. "Individualized, PK-Guided Dosing of Hydroxyurea for Young Children with Sickle Cell Anemia: Final Results from the Hydroxyurea Optimization through Precision Study (HOPS)." Blood 144, Supplement 1 (2024): 175. https://doi.org/10.1182/blood-2024-200426.

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Introduction: Hydroxyurea is standard of care for young children with sickle cell anemia (SCA), yet optimal dosing remains uncertain. We prospectively demonstrated that an individualized, pharmacokinetic (PK)-guided initial dosing strategy for children with SCA was feasible, safe, and effective in the single center TREAT trial (NCT02286154). The Hydroxyurea Optimization through Precision Study (HOPS, NCT03789591) was then designed to evaluate PK-guided dosing in a multicenter trial design to directly compare the benefits of PK-guided dosing to a standard weight-based dosing with gradual, stepw

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Paditz, K., H. Kluth, and M. Rodehutscord. "Relationship between graded doses of three microbial phytases and digestible phosphorus in pigs." Animal Science 78, no. 3 (2004): 429–38. http://dx.doi.org/10.1017/s1357729800058835.

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AbstractThe efficacy of three microbial phytases to increase the amount of digestible phosphorus (dP) was studied in pigs. A basal diet was prepared meeting the requirements of 30-kg pigs with the exception of P. Concentrations (in g/kg dry matter) were: P 2·9, phytate P 1·3, calcium (Ca) 6·9, and crude protein 208. Intrinsic phytase activity was below detection limit. Microbial phytase was supplemented from three sources (Aspergillus niger (Asp), Peniophora lycii (Pen), and consensus phytase (Con)) at the following levels (phytase units (FTU) per kg diet): 150, 300, 450, 600 and 900. Diets we

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Groheux, David, Loïc Ferrer, Jennifer Vargas, et al. "Multimodal machine learning model prediction of complete pathological response to neoadjuvant chemotherapy in triple-negative breast cancer." Journal of Clinical Oncology 40, no. 16_suppl (2022): 601. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.601.

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601 Background: Triple negative breast cancer (TNBC) is a biologically and clinically heterogenous disease, associated with poorer outcomes when compared with other subtypes of breast cancer. In early-stage TNBC, surgery with curative intent remains the mainstay of therapy. Neoadjuvant chemotherapy is often given prior to surgery and achieving pathological complete response (pCR) has been associated with improved long-term outcomes in terms of progression-free survival (PFS) and overall survival (OS). There is thus high clinical interest in the ability to accurately predict pCR status using ba

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Groheux, David, Loïc Ferrer, Jennifer Vargas, et al. "Multimodal machine learning model prediction of complete pathological response to neoadjuvant chemotherapy in triple-negative breast cancer." Journal of Clinical Oncology 40, no. 16_suppl (2022): 601. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.601.

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601 Background: Triple negative breast cancer (TNBC) is a biologically and clinically heterogenous disease, associated with poorer outcomes when compared with other subtypes of breast cancer. In early-stage TNBC, surgery with curative intent remains the mainstay of therapy. Neoadjuvant chemotherapy is often given prior to surgery and achieving pathological complete response (pCR) has been associated with improved long-term outcomes in terms of progression-free survival (PFS) and overall survival (OS). There is thus high clinical interest in the ability to accurately predict pCR status using ba

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Mohamad Nor, Mohamad Naimi, Suhaimi Ishak, and Amirul Faiz Osman. "DEVELOPING AN EFFECTIVE INDIVIDUAL AMIL CRITERIA." International Research Journal of Shariah, Muamalat and Islam 3, no. 6 (2021): 38–44. http://dx.doi.org/10.35631/irjsmi.36004.

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Amil is the backbone of zakat activities which, in general, play a role in collecting and distributing zakat. However, some incidents of mismanagement involve amil raise concerns about the quality and role of amil. The question arises on the effectiveness of the amil and what should be done to minimize the case of mismanagement among amil. There should be some criteria that need to be met in the appointment of amil so that the appointed amil can fulfill the vision of the zakat institution. This study suggested five main criteria in determining effective amil, namely background of amil, appoint

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Adimora, Ijele, Brendan E. Dempsey, Youdinghuan Chen, Kari Rosenkranz, Deborah L. Ornstein, and Monic R. Drescher. "Perioperative Bridging of Anticoagulation - Does Protocol Adherence Improve Outcomes?" Blood 134, Supplement_1 (2019): 935. http://dx.doi.org/10.1182/blood-2019-125325.

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Background: Perioperative warfarin management is a clinical challenge as it requires careful assessment of both thrombosis and bleeding risk associated with the planned procedure. In our experience, many clinicians favor bridging over not bridging and often use full dose unfractionated or low molecular weight heparin even when a prophylactic dose would be a reasonable alternative. To improve and standardize the complex decision-making process for anticoagulation management for patients undergoing elective surgery we introduced an evidenced-based perioperative bridging anticoagulation protocol

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Lypovetska, О. B., V. О. Prokopov, and M. Yu Antomonov. "Determination of carcinogenic health risk from chloroform of drinking water at inhalation and cutaneous entry into the organism with the use of simplified calculation formulas." Environment & Health 98 (1) (January 2021): 14–19. http://dx.doi.org/10.32402/dovkil2021.01.014.

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Objective: We developed the simplified formulas for the calculation of carcinogenic risk in case of inhalation and cutaneous entry of drinking water chloroform into the human body. Materials and methods: We calculated average daily lifetime doses for the oral, inhalation and cutaneous entry of drinking water chloroform into the human body according to the R.2.1.10.1920-04 and MU 2.2.4-122-2005. The calculation of carcinogenic risks was carried out taking into account the average daily entry of a chemical substance throughout life and the slope factor. Mathematical calculations were performed w

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Bogunov, Leonid A. "Change criteria as a factor of labour rationalization in the change of social-labour relations." Herald of Omsk University. Series: Economics 22, no. 2 (2024): 66–75. http://dx.doi.org/10.24147/1812-3988.2024.22(2).66-75.

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The aim of the study is to analyze the elaboration of the problems of labor change in the current conditions and methodological justification of ensuring the rationalization of labor, implemented primarily by individuals themselves. The relevance of the study is determined by the active transformation of existing social and labor relations and the need to ensure the adaptation of labor activity of individual subjects of labor to changing conditions. On the basis of institutional and neo-institutional approaches, as well as system-activity methodology, a critical understanding of the concept of

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