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Journal articles on the topic 'Indolizine'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Albota, Florin, Mino R. Caira, Constantin Draghici, Florea Dumitrascu, and Denisa E. Dumitrescu. "Sydnone C-4 heteroarylation with an indolizine ring via Chichibabin indolizine synthesis." Beilstein Journal of Organic Chemistry 12 (November 23, 2016): 2503–10. http://dx.doi.org/10.3762/bjoc.12.245.

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The synthesis of sydnones heteroarylated at C-4 with an indolizine was achieved by Chichibabin (Tschitschibabin) indolizine synthesis starting from the corresponding sydnone-N-pyridinium bromides. The latter compounds were also transformed to sydnone-indolizines connected through a keto group at the C-4 position by refluxing them in 1,2-epoxybutane with an activated alkyne. The structures of the new compounds were assigned by FTIR, NMR spectroscopy and X-ray analysis.

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2

Guidotti, Bruno Boni, Thiago Sabino da Silva, José Tiago Menezes Correia, and Fernando Coelho. "Brønsted-acid-catalyzed selective Friedel–Crafts monoalkylation of isatins with indolizines in water." Organic & Biomolecular Chemistry 18, no. 37 (2020): 7330–35. http://dx.doi.org/10.1039/d0ob01714k.

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3

Chan, Siu-Chung, Chi-Fung Yeung, Hau-Lam Shek, et al. "Iron(ii)-induced cycloisomerization of alkynes via “non-vinylidene” pathways for iron(ii)-indolizine and -indolizinone complexes." Chemical Communications 56, no. 83 (2020): 12644–47. http://dx.doi.org/10.1039/d0cc05081d.

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4

Botezatu (Dediu), Andreea Veronica, Georgiana Horincar, Ioana Otilia Ghinea, et al. "Whole-Cells of Yarrowia lipolytica Applied in “One Pot” Indolizine Biosynthesis." Catalysts 10, no. 6 (2020): 629. http://dx.doi.org/10.3390/catal10060629.

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A series of yeast strains was tested in order to evaluate their catalytic potential in biocatalysis of one-pot indolizine’s synthesis. Yeast cultivation was performed in a submerged system at 28 °C for 72 h at 180 rpm. An assessment of the reagents’ toxicity on yeast viability and metabolic functionality concluded that the growth potential of three Yarrowia lipolytica strains were least affected by the reactants compared to the other yeast strains. Further, crude fermentation products (biomass and cell-free supernatant)—obtained by submerged cultivation of these yeasts—were used in multistep c

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5

Venugopala, Katharigatta N., Sandeep Chandrashekharappa, Subhrajyoti Bhandary, et al. "Efficient Synthesis and Characterization of Novel Substituted 3-Benzoylindolizine Analogues via the Cyclization of Aromatic Cycloimmoniumylides with Electrondeficient Alkenes." Current Organic Synthesis 15, no. 3 (2018): 388–95. http://dx.doi.org/10.2174/1570179414666171024155051.

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Background: Indolizine pharmacophore is known to exhibit various promising pharmacological properties such as analgesic, anticancer, antihistaminic, antidiabetic, anti-inflammatory, antileishmanic, antimicrobial, antimutagenic, antioxidant, antitubercular, antiviral, larvicidal and herbicidal activities. Objective: In the present investigation, it was envisaged to synthesize a series of novel ethyl-7-substituted-3-(4- substituted benzoyl)-2-substituted indolizine-1-carboxylates by employing chromium(IV)oxide as dehydrogenating agent with triethylamine combination. Method: Synthesis of a series

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6

Ma, Lanchao, Bing Chen, Yunlong Guo, et al. "NIR polymers and phototransistors." Journal of Materials Chemistry C 6, no. 47 (2018): 13049–58. http://dx.doi.org/10.1039/c8tc03917h.

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A novel bisthiophene-fused diketopyrrolopyrrole unit (4,11-bis(2-octyldodecyl)-7H,14H-thieno[3′,2′:7,8]indolizino[2,1-a]thieno[3,2-g]indolizine-7,14-dione, BTI) has been designed as an electron acceptor and used to copolymerize with thiophene and bithiophene as electron donors to construct two D–A conjugated polymers, P1 and P2via Stille coupling, respectively.

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7

Chudík, Miloslav, Štefan Marchalín, and Katarína Havrilová. "Synthesis and Spectral Properties of Methyl 6-Acetyl- or 6-Cyano-3-amino-2-benzoyl-7-furyl-5-methylindolizine-8-carboxylates." Collection of Czechoslovak Chemical Communications 63, no. 6 (1998): 826–34. http://dx.doi.org/10.1135/cccc19980826.

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Good yields of methyl 6-acetyl- or 6-cyano-3-amino-2-benzoyl-5-methyl-7-(5-substituted-2-furyl)indolizine-8-carboxylates (5a-5f) were obtained in the reaction of corresponding 5-acetyl- or 5-cyano-2-formyl-4-(5-substituted-2-furyl)-6-methyl-1,4-dihydropyridine-3-carboxylated (4a-4f) with 3-phenyl-3-oxopropanenitrile. Spectral properties of the indolizines 5 are discussed.

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8

Mizuno, Shohta, Takashi Nishiyama, Hana Bessho, et al. "Total Synthesis and Biological Evaluation of 22-Hydroxyacuminatine and the Related Natural Products Norketoyobyrine and Naucleficine." Molecules 30, no. 12 (2025): 2650. https://doi.org/10.3390/molecules30122650.

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Aromathecin compounds—which contain the same indolizine core structure as camptothecin-like compounds—are expected to show anticancer activity. Among them, 22-hydroxyacuminatine—which has a substituent on the E-ring of the pentacyclic scaffold—exhibits topoisomerase 1 inhibitory activity; therefore, the development of efficient methods for its synthesis has been actively pursued. Herein, we report a versatile synthetic methodology for introducing various substituents on the E-ring, leading to the total synthesis of 22-hydroxyacuminatine as a model compound of the aromathecin family. The synthe

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9

Venugopala, Katharigatta N., Christophe Tratrat, Melendhran Pillay, et al. "Anti-Tubercular Activity of Substituted 7-Methyl and 7-Formylindolizines and In Silico Study for Prospective Molecular Target Identification." Antibiotics 8, no. 4 (2019): 247. http://dx.doi.org/10.3390/antibiotics8040247.

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Novel series of diversely substituted indolizines were designed, synthesized, and evaluated for their in vitro anti-mycobacterial activity against H37Rv and multi-drug-resistant (MDR) strains of Mycobacterium tuberculosis (MTB). Many compounds exhibited significant inhibitory activity against MTB H37Rv strains. Indolizines 2d, 2e, and 4 were also found to be active against MTB clinical isolates with multi-resistance to rifampicin and isoniazid. Indolizine 4 was identified as the most promising anti-mycobacterial agent, displaying minimum inhibitory concentration (MIC) values of 4 and 32 μg/mL

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10

Matsumoto, Kiyoshi, Yukio Ikemi, Motoo Shiro, Takane Uchida, and James William Lown. "Reactions of 5-cyano-1,4-diphenylpyridazino[4,5-a]indolizines with dimethyl acetylenedicarboxylate: regioselective formation of 1:2 Michael type adducts." Canadian Journal of Chemistry 71, no. 4 (1993): 529–33. http://dx.doi.org/10.1139/v93-075.

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Reactions of 5-cyano-1,4-diphenylpyridazino[4,5-a]indolizines with dimethyl acetylenedicarboxylate afforded the 1:2 adducts regioselectively and, unexpectedly, in a Michael fashion rather than in a 1,3-dipolar manner. The structure of the products was established by X-ray crystallography. Regiospecific formation of the observed product 3 can be explained by the higher nucleophilicity of the nitrogen at the 2 position than at the 3 position of the 5-cyano-1,4-diphenylpyridazino[4,5-a]indolizine 1 owing to the contribution of a resonance structure 5 to the hybrid. This favors two successive Mich

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11

Kim, Sunmi, Jeong Hwa Lee, Seok Hyun Yoon, and Ikyon Kim. "A regioselective [4 + 2] annulation approach to 5-acylindolizine-7-carbonitriles: generation of poly-substituted pyridines." Organic & Biomolecular Chemistry 19, no. 26 (2021): 5806–17. http://dx.doi.org/10.1039/d1ob00788b.

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A highly efficient [4 + 2] annulation approach to poly-functionalized indolizine-7-carbonitriles enables us to install nitrile, (hetero)aryl/alkyl, and acyl groups regioselectively on the pyridine unit of indolizine.

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12

Sekgota, Khethobole C., Michelle Isaacs, Heinrich C. Hoppe, et al. "Propylphosphonic acid anhydride–mediated amidation of Morita–Baylis–Hillman–derived indolizine-2-carboxylic acids." Journal of Chemical Research 45, no. 7-8 (2021): 674–78. http://dx.doi.org/10.1177/1747519820987156.

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Propylphosphonic acid anhydride has been successfully used as a coupling agent in the synthesis of a series of indolizine-2-carboxamido derivatives from indolizine-2-carboxylic acid and its 3-acetylated analogue. The acid substrates were obtained by saponification of the corresponding methyl esters produced, in turn, selectively and efficiently, by time-controlled cyclisation of a single Morita–Baylis–Hillman adduct. Various amino and hydrazino compounds with medicinal potential have been used to prepare indolizine-2-carboxamido and hydrazido derivatives.

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13

Kim, Taegwan, and Jonghoon Kim. "Color-Tunable Indolizine-Based Fluorophores and Fluorescent pH Sensor." Molecules 27, no. 1 (2021): 12. http://dx.doi.org/10.3390/molecules27010012.

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A new fluorescent indolizine-based scaffold was developed using a straightforward synthetic scheme starting from a pyrrole ring. In this fluorescent system, an N,N-dimethylamino group in the aryl ring at the C-3 position of indolizine acted as an electron donor and played a crucial role in inducing a red shift in the emission wavelength based on the ICT process. Moreover, various electron-withdrawing groups, such as acetyl and aldehyde, were introduced at the C-7 position of indolizine, to tune and promote the red shift of the emission wavelength, resulting in a color range from blue to orange

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14

Wang, Yefei, Zhen Yang, Fengtao Zhan, et al. "Correction: Indolizine quaternary ammonium salt inhibitors part II: a reinvestigation of an old-fashioned strong acid corrosion inhibitor phenacyl quinolinium bromide and its indolizine derivative." New Journal of Chemistry 43, no. 43 (2019): 17123–24. http://dx.doi.org/10.1039/c9nj90149c.

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Correction for ‘Indolizine quaternary ammonium salt inhibitors part II: a reinvestigation of an old-fashioned strong acid corrosion inhibitor phenacyl quinolinium bromide and its indolizine derivative’ by Yefei Wang et al., New J. Chem., 2018, 42, 12977–12989.

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15

Zhang, Yi-Zhu, Feng-Tao Sheng, Zuoquan Zhu, et al. "Organocatalytic C3-functionalization of indolizines: synthesis of biologically important indolizine derivatives." Organic & Biomolecular Chemistry 18, no. 29 (2020): 5688–96. http://dx.doi.org/10.1039/d0ob01230k.

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A Brønsted acid-catalyzed C3-alkylation of indolizines has been established with different electrophiles (E), which synthesized a series of C3-functionalized indolizines in overall good yields (up to 89%).

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16

Bayazit, Mustafa Kemal, Nihat Celebi, Selcuk Gumus, and Lemi Turker. "An experimental and theoretical approach to synthesis of novel indolizine type heterocycles." Celal Bayar Üniversitesi Fen Bilimleri Dergisi 16, no. 2 (2020): 129–34. https://doi.org/10.18466/cbayarfbe.457856.

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1,3-Dipolar cycloaddition reactions of certain pyridinium ylides with various dipolarophiles were studied. Synthesis of new indolizine heterocycles was achieved. The new indolizine systems were characterized spectroscopically. A theoretical study of the reactions was accomplished at FMO level (PM3-RHF calculations).

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17

N, Ramalakshmi, Amuthalakshmi S, Yamuna R, A. Smith Anton, and Arunkumar S. "Indolizine- A Privileged Biological Scaffold." Der Pharma Chemica 13, no. 2 (2021): 10. https://doi.org/10.5281/zenodo.14718468.

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Indolizine derivatives own cherished biological activities and have been studied for their hypoglycemic, antimicrobial, anti-inflammatory& analgesic, anti-tumour activities. Indolizine scaffold has fascinated speculation and continuing interest and has become an important parent system for the development of potent new drug candidates. The conjugated planar electronic structure exhibits strong fluorescence properties which serve as a valuable tool for DNA interaction and spectroscopic sensitizer studies. Thus, the chemistry, synthesis and properties of this merged system and its derivative

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18

Vrábel, Viktor, Július Sivý, Peter Šafář, and Jozef Kožíšek. "(11aS)-1,5,11,11a-Tetrahydro-1-benzothieno[3,2-f]indolizin-3(2H)-one." Acta Crystallographica Section E Structure Reports Online 69, no. 12 (2013): o1819—o1820. http://dx.doi.org/10.1107/s1600536813031693.

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The absolute configuration of the title compound, C14H13NOS, was assigned from the synthesis and confirmed by the structure determination. There are two independent molecules in the asymmetric unit. The central six-membered ring of the indolizine moiety adopts an envelope conformation, with the greatest deviations from the mean planes being 0.569 (3) and 0.561 (3) Å for the indolizine bridgehead C atoms of the two molecules. The benzothieno ring attached to the indolizine ring system is planar to within 0.015 (3) Å in both molecules. In the crystal, weak C—H...O and C—H...π interactions lead t

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19

Zhang, Xueguo, Jianpeng Zhang, Zhengyi Liu, Wenxuan Bi, Jian Shen, and Guang Li. "Efficient Solvent-Free Synthesis of Indolizines Using CuBr Catalyst from Pyridine, Acetophenone, and Electron-Deficient Alkenes." Molecules 29, no. 9 (2024): 2061. http://dx.doi.org/10.3390/molecules29092061.

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Herein, we have developed a new approach for the synthesis of indolizine via Cu-catalyzed reaction of pyridine, acetophenone, and nitroolefin under mild conditions in high yields. This reaction involved the formation of C–N and C–C bonds and new indolizine compounds with high stereoselectivity and excellent functional group tolerance.

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20

Tallarita, Roberto, Lukas Manuel Jacobsen, Benedict J. Elvers, et al. "Synthesis of Seven Indolizine-Derived Pentathiepines: Strong Electronic Structure Response to Nitro Substitution in Position C-9." Molecules 29, no. 1 (2023): 216. http://dx.doi.org/10.3390/molecules29010216.

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Seven new 1,2,3,4,5-pentathiepino[6,7-a]indolizines were synthesized in which the pentathiepine moieties bear an indolizine backbone that is derivatized from C–H to F-, Cl-, Br-, I-, NO2-, and CH3-substitutions, respectively, in a meta position relative to the aza group on the pyridine moiety. Their preparation took place via two common steps: (i) a Sonogashira coupling between (4-substituted) 2-bromo- or 2-chloropyridines and propynyl 3,3-diethylacetal, and (ii) a ring closing reaction mediated by a molybdenum oxo-bistetrasulfido complex and elemental sulfur. The latter simultaneously facilit

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21

Romo, Pablo E., Jairo Quiroga, Justo Cobo, and Christopher Glidewell. "Synthesis and spectroscopic and structural characterization of spiro[indoline-3,3′-indolizine]s formed by 1,3-dipolar cycloadditions between isatins, pipecolic acid and an electron-deficient alkene." Acta Crystallographica Section C Structural Chemistry 77, no. 9 (2021): 496–504. http://dx.doi.org/10.1107/s2053229621007142.

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Five new spiro[indoline-3,3′-indolizine]s have been synthesized with high regio- and stereospecificity in one-pot three-component reactions between a substituted indole-2,3-dione, (S)-pipecolic acid and trans-3-benzoylacrylic acid, and subsequently characterized using a combination of elemental analysis, IR and 1H and 13C NMR spectroscopy, mass spectrometry and crystal structure analysis. (1′SR,2′SR,3RS,8a′RS)-2′-Benzoyl-5-fluoro-2-oxo-1′,5′,6′,7′,8′,8a′-hexahydro-2′H-spiro[indoline-3,3′-indolizine]-1′-carboxylic acid, C23H21FN2O4, (I), and (1′SR,2′SR,3RS,8a′RS)-2′-benzoyl-5-methyl-2-oxo-1′,5′

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22

Saucier, Matthew A., Cameron Smith, Nicholas A. Kruse, Nathan I. Hammer, and Jared H. Delcamp. "Acid-Triggered Switchable Near-Infrared/Shortwave Infrared Absorption and Emission of Indolizine-BODIPY Dyes." Molecules 28, no. 3 (2023): 1287. http://dx.doi.org/10.3390/molecules28031287.

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Fluorescent organic dyes that absorb and emit in the near-infrared (NIR, 700–1000 nm) and shortwave infrared (SWIR, 1000–1700 nm) regions have the potential to produce noninvasive high-contrast biological images and videos. BODIPY dyes are well known for their high quantum yields in the visible energy region. To tune these chromophores to the NIR region, fused nitrogen-based heterocyclic indolizine donors were added to a BODIPY scaffold. The indolizine BODIPY dyes were synthesized via microwave-assisted Knoevenagel condensation with indolizine aldehydes. The non-protonated dyes showed NIR abso

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23

Bode, Moira L., and Perry T. Kaye. "Indolizine studies. Part 2. Synthesis and NMR spectroscopic analysis of 2-substituted indolizines." Journal of the Chemical Society, Perkin Transactions 1, no. 15 (1993): 1809. http://dx.doi.org/10.1039/p19930001809.

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24

Cai, Qun, Yan-Ping Zhu, Yang Gao, Jing-Jing Sun, and An-Xin Wu. "A direct method for the synthesis of indolizine derivatives from easily available aromatic ketones, pyridines, and acrylonitrile derivatives." Canadian Journal of Chemistry 91, no. 6 (2013): 414–19. http://dx.doi.org/10.1139/cjc-2012-0534.

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A concise and efficient strategy has been proposed to synthesize indolizine derivatives from easily available aryl or heteroaryl methyl ketones, pyridines, and acrylonitriles. The mechanistic pathway involved the integration of iodination, pyridinium ylide synthesis, and 1,3-dipolar cycloaddition. The protocols were found to be highly efficient in terms of high yields, operational simplicity, mild reaction conditions, and easy workup. This method has provided an important supplement for the synthesis of indolizine derivatives via a novel tandem synthesis.

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25

Chandrashekharappa, Sandeep, Katharigatta N. Venugopala, Christophe Tratrat, et al. "Efficient synthesis and characterization of novel indolizines: exploration of in vitro COX-2 inhibitory activity and molecular modelling studies." New Journal of Chemistry 42, no. 7 (2018): 4893–901. http://dx.doi.org/10.1039/c7nj05010k.

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26

Shen, Yong-Miao, Hoong-Kun Fun, and Jian-Hua Xu. "Dimethyl indolizine-1,6-dicarboxylate." Acta Crystallographica Section E Structure Reports Online 62, no. 9 (2006): o4080—o4081. http://dx.doi.org/10.1107/s1600536806033411.

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27

Gu, Wei-Jin, Jin Zhuang, Yu-Liang Jiang, and Bing-Xiang Wang. "Diethyl indolizine-1,3-dicarboxylate." Acta Crystallographica Section E Structure Reports Online 67, no. 1 (2010): o123. http://dx.doi.org/10.1107/s1600536810050919.

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28

Ji, Ruixue, Aikun Liu, Shili Shen, Xiaoqun Cao, Fei Li, and Yanqing Ge. "An indolizine–rhodamine based FRET fluorescence sensor for highly sensitive and selective detection of Hg2+ in living cells." RSC Advances 7, no. 65 (2017): 40829–33. http://dx.doi.org/10.1039/c7ra07938a.

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29

Yang, Jie, Yifan Zhu, Anfernee Kai-Wing Tse, et al. "Synthesis and study of Au(iii)–indolizine derivatives: turn-on luminescence by photo-induced controlled release." Chemical Communications 55, no. 31 (2019): 4471–74. http://dx.doi.org/10.1039/c8cc10177a.

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30

Naik, T. R. Ravikumar, G. Mahanthesha, and T. Suresh. "Synthesis and Biological Evaluation of (4-Fluorophenyl)(1-(5-phenyl-1,3,4-oxadiazol-2-yl)indolizin-3-yl)methanone Derivatives as Anti-cancer and Antimicrobial Agents." International Journal of Pharmaceutical Sciences and Drug Research 14, no. 01 (2022): 8–18. http://dx.doi.org/10.25004/ijpsdr.2022.140102.

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A novel series of (4-Fluorophenyl (1-(5-phenyl-1,3,4-oxadiazol-2-yl)indolizin-3-yl)methanone derivatives 9(a-n) were synthesized by the coupling reaction of 3-(4-fluorobenzoyl)indolizine-1-carboxylic acid and substituted benzohydrazide followed by intramolecular cyclization. The structures of the compounds were characterized by 1 H NMR, 13C NMR, LCMS, FT-IR, and elemental analyses. The compounds 9(a-n) anti-cancer activity was evaluated against the MCF-7 cell line (HTB-22, Homo sapiens, Breast carcinoma). Compound 9j (IC50 = 21.57 µM), and 9n (IC50 = 8.52 µM) exhibited the most potent cytotoxi

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31

Wang, Yefei, Zhen Yang, Fengtao Zhan, et al. "Indolizine quaternary ammonium salt inhibitors part II: a reinvestigation of an old-fashioned strong acid corrosion inhibitor phenacyl quinolinium bromide and its indolizine derivative." New Journal of Chemistry 42, no. 15 (2018): 12977–89. http://dx.doi.org/10.1039/c8nj02505c.

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32

Foster, C., M. Ritchie, D. L. Selwood, and W. Snowden. "Synthesis and Anti-Herpes Activity of a Series of Indolizines." Antiviral Chemistry and Chemotherapy 6, no. 5 (1995): 289–97. http://dx.doi.org/10.1177/095632029500600502.

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A systematic screening study identified 2-phenyl-indolizine [1] as having significant human cytomegalovirus (HCMV) activity (IC50 = 7-19 μM). Preliminary mode of action studies on infected cells treated with [1] indicated supression of HCMV-related polypeptides with little effect on the host cells. A series of analogues were synthesized, some of which showed improved HCMV activity although with lower therapeutic indices than [1]. Several analogues demonstrated significant varicella zoster virus activity, with 2-(4-cyanophenyl)indolizine [5] having an IC50 of 5 μM and a therapeutic index of 20

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33

Sarkar, Rajib, Tandrima Chaudhuri, Animesh Karmakar та Chhanda Mukhopadhyay. "Synthesis and photophysics of selective functionalized π-conjugated, blue light emitting, highly fluorescent C7-imidazo indolizine derivatives". Organic & Biomolecular Chemistry 13, № 48 (2015): 11674–86. http://dx.doi.org/10.1039/c5ob01646k.

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34

Bode, Moira L., Perry T. Kaye, and Rosemary George. "Indolizine studies. Part 3. Synthesis and dynamic NMR analysis of indolizine-2-carboxamides." Journal of the Chemical Society, Perkin Transactions 1, no. 20 (1994): 3023. http://dx.doi.org/10.1039/p19940003023.

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35

Kakehi, Akikazu, Suketaka Ito, Shin-ichi Matsumoto, and Yuichiro Morimoto. "Regiospecific Formations of Thieno[3,2-a]indolizine and Thieno[2,3-b]indolizine Derivatives." Chemistry Letters 16, no. 10 (1987): 2043–46. http://dx.doi.org/10.1246/cl.1987.2043.

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36

Liu, Ren-Rong, Zheng-Yi Cai, Chuan-Jun Lu, et al. "Indolizine synthesis via Cu-catalyzed cyclization of 2-(2-enynyl)pyridines with nucleophiles." Organic Chemistry Frontiers 2, no. 3 (2015): 226–30. http://dx.doi.org/10.1039/c4qo00336e.

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37

Huang, Cheng, Zhifei Zhao, Shiwu Li, Jixing Zhao, Leifang Wu, and Chengzhi Gu. "Catalytic asymmetric conjugate addition of indolizines to unsaturated ketones catalyzed by chiral-at-metal complexes." Organic Chemistry Frontiers 9, no. 7 (2022): 1932–36. http://dx.doi.org/10.1039/d1qo01657a.

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38

Huckaba, Aron J., Aswani Yella, Phillip Brogdon, et al. "A low recombination rate indolizine sensitizer for dye-sensitized solar cells." Chemical Communications 52, no. 54 (2016): 8424–27. http://dx.doi.org/10.1039/c6cc02247b.

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39

Chatterjee, Satadru, William E. Meador, Cameron Smith, et al. "SWIR emissive RosIndolizine dyes with nanoencapsulation in water soluble dendrimers." RSC Advances 11, no. 45 (2021): 27832–36. http://dx.doi.org/10.1039/d1ra05479a.

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40

AbdelSamad, Amr L., Mohammed T. El-Saadi, Ahmed M. Gouda, and Asmaa M. AboulMagd. "Pyrrolizine/indolizine-bearing (un)substituted isoindole moiety: design, synthesis, antiproliferative and MDR reversal activities, and in silico studies." RSC Advances 13, no. 44 (2023): 30753–70. http://dx.doi.org/10.1039/d3ra05310e.

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41

Chen, Hong-Ru, Zhen-Yu Hu, Hua-Li Qin, and Haolin Tang. "A novel three-component reaction for constructing indolizine-containing aliphatic sulfonyl fluorides." Organic Chemistry Frontiers 8, no. 6 (2021): 1185–89. http://dx.doi.org/10.1039/d0qo01430c.

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Bloch, Witold M., Stephanie M. Derwent-Smith, Fatiah Issa, Jonathan C. Morris, Louis M. Rendina, and Christopher J. Sumby. "Fused pyrazino[2,3-b]indolizine and indolizino[2,3-b]quinoxaline derivatives; synthesis, structures, and properties." Tetrahedron 67, no. 48 (2011): 9368–75. http://dx.doi.org/10.1016/j.tet.2011.09.133.

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BODE, M. L., and P. T. KAYE. "ChemInform Abstract: Indolizine Studies. Part 2. Synthesis and NMR Spectroscopic Analysis of 2-Substituted Indolizines." ChemInform 24, no. 51 (2010): no. http://dx.doi.org/10.1002/chin.199351191.

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Ceder, Olof, and Mohammed Rashid Sharif. "The reaction of indolizines with esters of orthoformic acid: synthesis of tris-indolizine molecular propellers." Chemische Berichte 120, no. 2 (1987): 239–42. http://dx.doi.org/10.1002/cber.19871200217.

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Au-Alvarez, O., V. A. Tafeenko, and L. A. Aslanov. "Structural study of indolizine derivatives." Acta Crystallographica Section A Foundations of Crystallography 52, a1 (1996): C274. http://dx.doi.org/10.1107/s010876739608854x.

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Kaupp, Gerd, and Ernst Ringer. "The first photocycloadditions of indolizine." Tetrahedron Letters 28, no. 49 (1987): 6155–58. http://dx.doi.org/10.1016/s0040-4039(00)61834-8.

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Sharma, Vikas, and Vipin Kumar. "Indolizine: a biologically active moiety." Medicinal Chemistry Research 23, no. 8 (2014): 3593–606. http://dx.doi.org/10.1007/s00044-014-0940-1.

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Birr, Emil-Joachim, and Werner Walther. "Zur Konstitution der Triaza-indolizine." Chemische Berichte 86, no. 11 (2006): 1401–3. http://dx.doi.org/10.1002/cber.19530861104.

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Bonnaud, Bernard, Dennis Bigg, and Jean-François Patoiseau. "Synthesis of novel indolizine derivatives." Journal of Heterocyclic Chemistry 28, no. 8 (1991): 1927–32. http://dx.doi.org/10.1002/jhet.5570280820.

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Tukulula, Matshawandile, Rosalyn Klein, and Perry T. Kaye. "Indolizine Studies, Part 5: Indolizine-2-carboxamides as Potential HIV-1 Protease Inhibitors[1]." Synthetic Communications 40, no. 13 (2010): 2018–28. http://dx.doi.org/10.1080/00397910903219450.

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