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Dissertations / Theses on the topic 'Influenza B virus'

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Published: 4 June 2021

Last updated: 25 July 2025

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1

Pavan, Carmen M. "Influenza B virus : segment 7 gene expression." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=55673.

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2

Rowley, Kathryn Victoria. "Genetic manipulation of influenza B virus segment 6." Thesis, University of Reading, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314321.

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3

MAENO, KOICHIRO. "Replication of Influenza B Virus: Biological Functions of Viral Neuraminidase." Nagoya University School of Medicine, 1994. http://hdl.handle.net/2237/15935.

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4

Tsang, Chi-ho, and 曾志豪. "A multi-probe quantitative PCR assay for genotyping of influenza B virus." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B49828599.

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Influenza B virus contributes to a significant portion of influenza disease burden in men. It is structurally similar and replicates in the same manner as the influenza A virus, leading to a comparable clinical presentation between the two viral species. Since 1977, influenza B has caused seasonal epidemics around the world together with A/H1N1 and A/H3N2 subtypes, and has a strong affinity to affect children of school age and young adults. In the 1980s, two antigenically distinct lineages of influenza B virus emerged, one being the B/Yamagata lineage and the other known as B/Victoria linea

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5

Huang, Kuan-Ying. "B cell and antibody responses to influenza A virus in human." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:3c24c905-15e2-4547-944e-e1a46a6aacd0.

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Neutralising antibodies and antigen-specific B cells are important for protection against influenza A virus. However, the antigenic evolution of influenza A viruses has made a continuing challenge to the design of vaccine and the public health. The ability to generate cross-reactive response against influenza remains unclear in human. It is important to explore the antibody and B cell repertoire at single cell level. The pandemic H1N1 and seasonal influenza vaccine induced robust antibody response in adults. However, pre- or co-vaccination with the seasonal vaccine led to a significantly reduc

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6

Schneider, Jana [Verfasser]. "Charakterisierung nuklearer Funktionen des Nichtstrukturproteins von Influenza-B-Virus / Jana Schneider." Berlin : Freie Universität Berlin, 2009. http://d-nb.info/1023665859/34.

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7

Boyden, Alexander Wiser. "Influenza A virus induces regulated T cell-driven B cell responses." Diss., University of Iowa, 2012. https://ir.uiowa.edu/etd/3432.

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Protection from influenza A virus (IAV) challenge requires switched, high affinity Abs derived from long-lived memory B cells and plasma cells. These subsets are generated in germinal centers (GCs), hallmark structures of T helper cell-driven B cell immunity. A full understanding of the acute and persistent GC B cell reaction following respiratory IAV infection is lacking, as is the characterization of IAV-induced T follicular helper (TFH) cells that support GCs. Additionally, it remains unclear as to whether IAV-induced GC B cells are subject to control by regulatory T cells (Tregs). To addre

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8

INOUE, HIROMASA, and ARIFUMI KUNO. "Antigenic Analysis of Influenza B Virus Isolated from the Epidemic in 1973." Nagoya University School of Medicine, 1985. http://hdl.handle.net/2237/17471.

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9

Wang, Xiaohui, and 王晓辉. "The role of IL-17A in modulating B cell response during influenza virus infection." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/208035.

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Interleukin-17A (IL-17A)is an important pro-inflammatory cytokine that plays a critical role in host defenses against diverse pathogens. Studies have shown that IL-17Aplays protective role against sub-lethal H1 and H3 subtypes influenza infections, but it is unclear about the role of IL-17A in the highly pathogenic H5N1 and lethal H1N1 influenza virus infection. B cell is an important effector cell type in anti-influenza immunity. Although roles of B cell in influenza infection have been extensively investigated, it is unclear whether and how IL-17AregulatesB cell response during influenza inf

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10

Audsley, Jennifer M., and jennifer audsley@med monash edu au. "Alternative Approaches In The Preparation And Growth Of Influenza B Vaccine Viruses." RMIT University. Applied Sciences, 2008. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20080414.141937.

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Influenza B viruses are a significant cause of disease and influenza B antigens are present in all human vaccines. Achieving suitable yields of seed viruses is often difficult for vaccine manufacturers. With influenza A viruses increases in yields have been achieved by the preparation of reassortants between a high-yielding donor strain and an epidemic strain. However, reassortment of influenza B viruses for the preparation of seeds has not been usually undertaken due to the lack suitable donor strains. Such an approach, which formed the basis of this thesis, could improve vaccine yields, lowe

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11

Nannetti, Giulio. "Sviluppo e caratterizzazione di nuovi inibitori diretti contro la polimerasi dei virus dell'influenza di tipo A e B." Doctoral thesis, Università degli studi di Padova, 2014. http://hdl.handle.net/11577/3423848.

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Influenza (flu) is an airborne highly-infectious disease, characterized by high morbidity and significant mortality, especially in at-risk population (young children, elderly people, patients with chronic disease). Influenza type A (IAV) and type B (IBV) viruses, characterized by remarkable genetic instability and antigenic variability, are responsible for seasonal epidemics, which affect every year 15-20% of the world population. In addition, IAV is able to infect a wide variety of birds and mammals and as happened with the recent case of H1N1 swine flu, a genetic reassortment between viral g

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12

Reiche, Sven, Yamen Dwai, Bianca M. Bussmann, Susanne Horn, Michael Sieg, and Christian Jassoy. "High inter-individual diversity of point mutations, insertions, and deletions in human influenza virus nucleoprotein-specific memory B cells." Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-172324.

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The diversity of virus-specific antibodies and of B cells among different individuals is unknown. Using single-cell cloning of antibody genes, we generated recombinant human monoclonal antibodies from influenza nucleoprotein-specific memory B cells in four adult humans with and without preceding influenza vaccination. We examined the diversity of the antibody repertoires and found that NP-specific B cells used numerous immunoglobulin genes. The heavy chains (HCs) originated from 26 and the kappa light chains (LCs) from 19 different germ line genes. Matching HC and LC chains gave rise to 43 gen

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13

Sherry, Lee. "Investigating the antiviral activity of the interferon-inducible GTPase MxA against influenza viruses." Thesis, University of St Andrews, 2016. http://hdl.handle.net/10023/8072.

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The interferon (IFN) system forms an essential part of the innate immune response, up-regulating hundreds of IFN-stimulated genes (ISGs) in response to viral infection. A key protein in this response is the human myxovirus resistance protein MxA, an IFN-induced GTPase with broad-spectrum antiviral activity, capable of inhibiting many RNA and DNA viruses. One of the most studied antiviral effects of MxA is the inhibition of influenza A virus replication, yet the molecular mechanism of antiviral activity is still unknown. Influenza A viruses are inhibited by MxA at two distinct stages of viral r

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14

Ng, Hoi-yee Iris, and 吳凱怡. "Serological diagnosis of influenza B virus infection in pigs : a comparison of the hemagglutination inhibition assay and the cell-based ELISA assay." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/193797.

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Background Swine influenza virus (SIV) was first isolated in the United States in 1930 and was thereafter widely reported in many countries. Most SIVs that have been identified are influenza A viruses. There was no report of influenza B viruses isolated in swine. Seroepidemiological study in UK has shown a low seroprevalence of influenza B antibody in pigs. The primary serological test used to detect influenza antibody is the hemagglutination inhibition (HI)test. Enzyme-linked immunosorbent assay (ELISA) are also available commercially for detection of antibodies against influenza A viruses b

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15

Wurzer, Walter. "Die Rolle des Transkriptionsfaktors NF-kB [NF-kappa-B] in Influenza-A-Virus-infizierten Zellen." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968366732.

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16

Yuan, Weiming. "Novel anti-interferon mechanism : influenza B virus both induces and blocks the activity of the ubiquitin-like ISG15 protein /." Full text (PDF) from UMI/Dissertation Abstracts International, 2000. http://wwwlib.umi.com/cr/utexas/fullcit?p9992947.

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17

Turnbull, Matthew Luke. "The role of the NS segment of Influenza A virus in setting host range and pathogenicity." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/25468.

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Influenza A virus (IAV) circulates in waterfowl, causing mostly asymptomatic infections. IAV can undergo host adaptation and evolve to cause significant disease and mortality in domestic poultry and mammals, applying an enormous socio-economic burden on society. Sporadically, IAV causes global pandemics in man due to its zoonotic nature, and this can result in millions of deaths worldwide during a single outbreak. Host adaptation of IAV is an incompletely understood phenomenon, but is known to involve both host and viral determinants. It is essential to improve the understanding of the factors

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18

Sadewasser, Anne [Verfasser]. "Aktivitäten des Nichtstrukturproteins 1 bei der Vermehrung von Influenza B Virus in humanen Zellen / Anne Sadewasser." Berlin : Freie Universität Berlin, 2014. http://d-nb.info/1049189639/34.

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19

Dhenni, Rama B. S. "Role of Granzyme B in the Susceptibility to Secondary Bacterial Infection after Viral Infection." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1460446984.

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20

Goldman, Lea Nichole. "Kinetics and phenotype of the draining lymph node and pulmonary B cell response to an influenza A virus-like particle vaccine." Thesis, University of Iowa, 2013. https://ir.uiowa.edu/etd/4634.

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Influenza A virus (IAV) infection is a serious respiratory disease associated with significant morbidity and mortality worldwide. Annual vaccination is the most effective way to prevent infection and its potentially severe complications; however, the vaccines currently offered have several drawbacks that limit its availability and protective efficacy. Influenza virus-like particles (VLPs), which lack viral genetic material and are non-infectious, represent a promising vaccine candidate. Previous reports have shown VLPs are more immunogenic than subunit or recombinant proteins, and confer prote

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21

Kemdirim, Stella C. "Molecular cloning of the polymerase genes of influenza B virus : complete nucleotide sequence of the virus genome RNA segment encoding the PBI protein." Thesis, McGill University, 1986. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=65397.

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22

Zacharias, Zeb Ralph. "Induction and maintenance of diverse humoral and cellular immune responses following influenza A virus infection and vaccination." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6669.

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Influenza A virus (IAV) is a major cause of serious respiratory illness worldwide, leading to approximately 5 million severe cases and 500,000 deaths per year. Given the disease severity, associated economic costs, and recent appearance of novel IAV strains, there is a renewed interest in developing novel and efficacious “universal” IAV vaccination strategies as well as therapeutic remedies. Previous studies from our laboratory have concentrated on IAV-specific CD8 T cell-mediated protection against IAV infection as IAV-specific CD8 T cells are needed for efficient clearance of virus. Recent s

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23

Fage, Clément. "Étude de la résistance des virus influenza B contemporains aux inhibiteurs de la neuraminidase et son impact sur le fitness viral." Doctoral thesis, Université Laval, 2019. http://hdl.handle.net/20.500.11794/36444.

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Les virus influenza ont toujours eu un impact considérable sur l’humanité. Les virus influenza B (IB) ont longtemps été négligés et sous-estimés par rapport aux virus influenza A (IA). Ils ne représentent que 10 à 20% des infections annuelles par les virus influenza, mais peuvent devenir majoritaire certaines années et entrainer des symptômes similaires à ceux des virus IA. Les inhibiteurs de la neuraminidase (INA) sont les principaux traitements disponibles contre les virus influenza. Cependant, à la suite de mutations, certains virus influenza ont développé des mécanismes de résistance limit

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24

Goka, Edward Anthony Chilongo. "Influenza A viruses dual and multiple infections with other respiratory viruses and risk of hospitalization and mortality." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/influenza-a-viruses-dual-and-multiple-infections-with-other-respiratory-viruses-and-risk-of-hospitalization-and-mortality(256eb122-a52a-4276-8dc1-28b5a2cc6662).html.

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Introduction: Epidemiological studies have indicated that 5-38% of influenza like illnesses (ILI) develop into severe disease due to, among others, factors such as; underlying chronic diseases, age, pregnancy, and viral mutations. There are suggestions that dual or multiple virus infections may affect disease severity. This study investigated the association between co-infection between influenza A viruses and other respiratory viruses and disease severity. Methodology: Datum for samples from North West England tested between January 2007 and June 2012 was analysed for patterns of co-infection

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25

Tissot, Alice. "Caractérisation Structurale et Biochimique de la Nucléoprotéine des virus grippaux de type A, B et D." Thesis, Université Grenoble Alpes (ComUE), 2017. http://www.theses.fr/2017GREAV014/document.

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Le virus de la grippe est un virus à ARN négatif appartenant à la famille des Orthomyxoviridae qui se compose de 7 membres dont les virus influenza A, B, C et D. Le génome viral comprend 7 à 8 particules ribonucléoprotéiques (RNP) au sein desquelles l’ARN viral (ARNv) est recouvert de multiples copies de nucléoprotéines (NP) et est associé à l’ARN polymérase virale via ses extrémités 3’ et 5’. Au cours de ce travail de thèse, nous nous sommes tout d’abord focalisés sur l’étude biochimique de NP A et NP B et avons pu mettre en évidence des comportements différents en ce qui concerne leurs propr

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26

Williams, Jonathan K., Alexander A. Shcherbakov, Jun Wang, and Mei Hong. "Protonation equilibria and pore-opening structure of the dual-histidine influenza B virus M2 transmembrane proton channel from solid-state NMR." AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2017. http://hdl.handle.net/10150/626055.

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The influenza A and B viruses are the primary cause of seasonal flu epidemics. Common to both viruses is the M2 protein, a homotetrameric transmembrane proton channel that acidifies the virion after endocytosis. Although influenza A M2 (AM2) and B M2 (BM2) are functional analogs, they have little sequence homology, except for a conserved HXXXW motif, which is responsible for proton selectivity and channel gating. Importantly, BM2contains a second titratable histidine, His-27, in the tetrameric transmembrane domain that forms a reverse WXXXH motif with the gating tryptophan. To understand how H

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27

Baumruck, Andreas [Verfasser], Alesia Akademischer Betreuer] Tietze, and Harald [Akademischer Betreuer] [Kolmar. "Chemical synthesis of membrane-associated peptides: A model study on influenza virus B protein BM2(1-51) / Andreas Baumruck ; Alesia Tietze, Harald Kolmar." Darmstadt : Universitäts- und Landesbibliothek Darmstadt, 2020. http://d-nb.info/1210644908/34.

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28

Baumruck, Andreas [Verfasser], Alesia [Akademischer Betreuer] Tietze, and Harald [Akademischer Betreuer] Kolmar. "Chemical synthesis of membrane-associated peptides: A model study on influenza virus B protein BM2(1-51) / Andreas Baumruck ; Alesia Tietze, Harald Kolmar." Darmstadt : Universitäts- und Landesbibliothek Darmstadt, 2020. http://d-nb.info/1210644908/34.

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29

Burmeister, Wilhelm Pascal. "Détermination de la structure de la neuraminidase du virus de la grippe B/Beijing/1/87 par cristallographie aux rayons X." Grenoble 1, 1992. http://www.theses.fr/1992GRE10138.

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Nous avons determine la structure de la neuraminidase du virus de la grippe souche b par la methode des derives lourds. Elle a ete affinee jusqu'a une resolution de 2. 2 a. La structure est tres similaire a celle de la neuraminidase des souches a. Deux sites de liaison de calcium, un sur l'axe d'ordre 4 du tetramere et un par sous-unite, ont ete identifies. Le premier site est capable de lier une variete de differents ions, comme l'analyse aux rayons x des cristaux dans lesquels nous avions fait diffuser des ions, l'a montre. Le deuxieme site montre toujours une pleine occupation par un ion ca

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30

Gravel, Emilie. "Hepsine et matriptase activent l’hémagglutinine des virus influenza A et B et leur inhibition représente une nouvelle stratégie thérapeutique n’entraînant pas le développement de résistance." Mémoire, Université de Sherbrooke, 2016. http://hdl.handle.net/11143/9464.

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Résumé: Chaque année, les épidémies saisonnières d’influenza causent de 3 à 5 millions de cas sévères de maladie, entraînant entre 250 000 et 500 000 décès mondialement. Seulement deux classes d’antiviraux sont actuellement commercialisées pour traiter cette infection respiratoire : les inhibiteurs de la neuraminidase, tels que l’oseltamivir (Tamiflu) et les inhibiteurs du canal ionique M2 (adamantanes). Toutefois, leur utilisation est limitée par l’apparition rapide de résistance virale. Il est donc d’un grand intérêt de développer de nouvelles stratégies thérapeutiques pour le traitement de

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31

Hestin, Marc. "Etude clinique de la grippe b : a propos de cinq observations." Université Louis Pasteur (Strasbourg) (1971-2008), 1987. http://www.theses.fr/1987STR1M263.

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32

YELSCH, PHILIPPE. "Influence des virus du sida sur les profils serologiques des sujets infectes par le virus de l'hepatite." Limoges, 1989. http://www.theses.fr/1989LIMO0177.

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33

Przewlocki, Grzegorz. "Influence du murabutide sur la réponse immunitaire à des antigènes naturels et synthétiques du virus de l'hépatite B." Paris 6, 1986. http://www.theses.fr/1986PA066135.

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34

Mäkelä, M. (Mira). "Influenssa A- ja B-virus sekä käytössä olevat influenssarokotteet ja kehitteillä olevat universaalit influenssarokotteet." Bachelor's thesis, University of Oulu, 2018. http://urn.fi/URN:NBN:fi:oulu-201804201511.

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Influenssa A- ja B-virukset ovat negatiivisäikeisiä RNA-viruksia, joiden genomi on segmentoitunut kahdeksaan osaan. Influenssa A-virus voidaan luokitella alatyyppeihin kalvoglykoproteiinien: hemagglutiniinin (HA) ja neuraminidaasin (NA) avulla. Influenssavirukset aiheuttavat kausittaisia epidemioita sekä ajoittain odottamattomia pandemioita. Kausi-influenssaepidemiat aiheutuvat kahdesta influenssa A-viruksen alatyypistä (H1N1 ja H3N2) sekä kahdesta influenssa B-viruksen linjasta (Yamagata ja Victoria). Influenssaviruksilta voi suojautua rokotteen avulla, jonka tehokkuus vaihtelee 60–90 % välil

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35

Eschlimann, Marine. "Influence de la variabilité des protéines d’enveloppe du virus de l’hépatite B sur l’évolution de l’infection évaluée par la persistance de l’antigène HBs." Thesis, Université de Lorraine, 2017. http://www.theses.fr/2017LORR0133/document.

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L’hépatite B chronique touche environ 257 millions de personnes dans le monde. La perte de l’antigène HBs (AgHBs), marqueur de guérison fonctionnelle, n’est que très rarement observée, même sous traitement antiviral (3-16 %). Les protéines d’enveloppe du virus de l’hépatite B (VHB), formant l’AgHBs, sont très variables et cruciales pour le pouvoir infectieux du virus de l’hépatite B (VHB) et la physiopathologie. Nous avons émis l’hypothèse que cette variabilité pourrait expliquer, au moins partiellement, l’évolution de l’infection par le VHB, évaluée par la clairance de l’AgHBs, chez des patie

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36

Finkernagel, Malin [Verfasser]. "Influence of vitamin D on the hepatitis B virus life cycle in different genotypes / Malin Finkernagel." Mainz : Universitätsbibliothek Mainz, 2017. http://d-nb.info/1124025464/34.

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37

Velay, Aurélie. "Influence des protéines d’enveloppe du virus de l’hépatite B sur la disparition de l’antigène HBs circulant lors du traitement de l’hépatite chronique B par analogues nucléos(t)idiques : mécanismes moléculaires impliqués et développement d’un traitement immunomodulateur à base d’anticorps monoclonaux." Thesis, Université de Lorraine, 2015. http://www.theses.fr/2015LORR0284/document.

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L'hépatite B chronique reste un problème majeur de santé publique. Sous traitement par analogues nucléos(t)idiques (NUCs), l'objectif thérapeutique ultime est la clairance de l'antigène (Ag) HBs. Nous avons étudié l'influence de la variabilité des protéines d'enveloppe, impliquées dans l'entrée cellulaire du virus et cibles de la réponse immune, sur la clairance de l'Ag HBs. Des patients traités par NUCs ayant obtenu une clairance de l'Ag HBs (resolvers) ont été appariés à des non-resolver. Deux mutations combinées sT125M/sP127T, caractéristiques des non-resolver, étaient associées à une baiss

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38

Przewlocki, Grzegorz. "Influence du murabutide sur la réponse immunitaire à des antigènes naturels et synthétiques du virus de l'hépatite B." Grenoble 2 : ANRT, 1986. http://catalogue.bnf.fr/ark:/12148/cb37600494n.

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39

Mohr, Christina [Verfasser]. "Influence of hepatitis B virus surface protein variants associated with antiviral resistance on viral assembly and secretion of hepatitis B and hepatitis D viruses / Christina Mohr." Gießen : Universitätsbibliothek, 2014. http://d-nb.info/1068540001/34.

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40

Sohlberg, Ebba. "Immune maturation in early childhood and the influence of herpesvirus infections." Doctoral thesis, Stockholms universitet, Institutionen för molekylär biovetenskap, Wenner-Grens institut, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-93034.

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The quality of immune responses develops from birth into adulthood and in the context of the host microbial environment. The aim of this work was to study immune maturation during childhood, and how this process can be affected by the common herpesviruses; Epstein-Barr virus (EBV) and cytomegalovirus (CMV). In paper I we studied monocytes, an important cell type for immunity in the newborn. We showed that the neonatal monocyte subsets exist in similar frequencies as adult subsets, and have a potent capacity for pro-inflammatory cytokine production. In paper II, III and IV we studied the effect

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41

Mohamed, Ajayeb Dakhelallah. "The influence of HLA in chronic hepatitis B and C and analysis of a new subtype of hepatitis C virus." Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243795.

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42

Boudou, Valérie. "Synthèse et propriétés biologiques de Bêta-pentofurano-nucléosides de l'adénine d'énantiomérie non naturelle L : influence des substituants et des configurations en position(s) 2' et/ou 3'." Montpellier 2, 1997. http://www.theses.fr/1997MON20185.

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Afin de parvenir a de nouveaux composes antiviraux, plus actifs et moins toxiques que ceux actuellement utilises en clinique humaine, nous avons axe notre travail vers la synthese et l'etude d'analogues nucleosidiques de l'adenine, d'anomerie et d'enantiomerie non naturelle l. Le premier chapitre de cette these resume, a partir d'etudes bibliographiques, les proprietes biologiques de certains -l-nucleosides. Le second chapitre porte sur la synthese stereospecifique des quatre -l-pentofuranonucleosides de l'adenine, de leurs deux homologues 2'-desoxygenes et de la l-adenosine 5'-triphosphate. L

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43

Gómez, Basilio Rosario. "Respuesta a la vacuna del virus hepatitis B en pacientes en hemodialisis: influencia e importancia como factor pronóstico de morbilidad y mortalidad." Doctoral thesis, Universitat de Lleida, 1994. http://hdl.handle.net/10803/300299.

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El objetivo del estudio es poner de manifiesto en hemodializados un hecho demostrado en población general, la interrelación entre inmunidad y desnutrición. El porcentaje de pacientes respondedores a la vacuna de Hepatitis B es 60.9%, similar a resultados de otros grupos e inferior a la obtenida en población normal a pesar de utilizar doble dosis. Este hecho expresa el déficit inmunitario existente en pacientes con insuficiencia renal crónica. La desnutrición influye desfavorablemente en la respuesta a la vacuna del virus VHB, siendo los factores más estrechamente asociados la urea prehe

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44

Williams, John. "A mathematical model of the dynamics of hepatitis B virus transmission in the UK under the influence of different vaccination control strategies." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298721.

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Stross, Leonhard Verfasser], Jörg [Akademischer Betreuer] Durner, and Ulrike [Akademischer Betreuer] [Protzer-Knolle. "The Influence of Regulatory T cells and other Immunoregulators on the Course of Hepatitis B Virus Infection / Leonhard Stross. Gutachter: Ulrike Protzer. Betreuer: Jörg Durner." München : Universitätsbibliothek der TU München, 2011. http://d-nb.info/1019588802/34.

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Barthel, Sebastian Robert [Verfasser], Eberhard [Akademischer Betreuer] [Gutachter] Hildt, and Robert [Akademischer Betreuer] [Gutachter] Tampé. "Influence of hepatitis B virus on insulin receptor signaling and liver regeneration / Sebastian Robert Barthel. Betreuer: Eberhard Hildt ; Robert Tampé. Gutachter: Robert Tampé ; Eberhard Hildt." Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg, 2016. http://d-nb.info/1112601643/34.

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Chetaille, Bruno. "Facteurs pronostiques biopathologiques des lymphomes Hodgkiniens : influence du microenvironnement." Thesis, Aix-Marseille 2, 2010. http://www.theses.fr/2010AIX20666/document.

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Les lymphomes hodgkiniens(LH) représentent 30% des lymphomes. 90 % des patients en sont gueris mais parfois au prix d'importants effets secondaires(cancers secondaires notamment). L'enjeu actuel consiste à identifier les patients susceptibles de bénéficier d'une déescalade thérapeutique(même résultat thérapeutique obtenu au prix d'un traitement moins lourd)Actuellemnt les facteurs pronostiques utilisé en routine(stade Ann Arbor et index pronostic internationnal) ne permettent qu'une stratification imparfaite des patients notamment pour les stades localisés. Dans le but d'identifier de nouveaux

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"Diversifying selective pressure on influenza B virus hemagglutinin." Thesis, 2009. http://hdl.handle.net/1911/61806.

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Influenza B virus hemagglutinin (HA) is a major surface glycoprotein with frequent amino-acid substitutions. However, the roles of antibody selection in the amino-acid substitutions of HA were still poorly understood. In order to gain insights into this important issue, an analysis was conducted on a total of 271 HA1 sequences of influenza B virus strains isolated during 1940&sim;2007. In this analysis, PAML (Phylogenetic Analysis by Maximum Likelihood) package was used to detect the existence of positive selection and to identify positively selected sites on HA1. Strikingly, all the positivel

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Jen, Hsiao Mei, and 蕭美人. "Genetic analysis of influenza B virus in Taiwan." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/96979194996838060359.

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碩士<br>長庚大學<br>醫學生物技術研究所<br>94<br>The segmented genome of influenza B virus allows the exchange of gene segments between cocirculating strains of Victoria viruses and Yamagata viruses. Through the process of reassortment, diversity is generated by recombination of genes between viruses that differ in one or more gene segments. In this study, forty strains of influenza B virus were isolated and identified between 2000 and 2005. Throat swabs were collected from patients suffering from influenza B virus in medical centers in northern parts of Taiwan. To elucidate the molecular characteristics of t

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Ni, Fengyun. "Functional and structural studies of influenza B virus hemagglutinin." Thesis, 2013. http://hdl.handle.net/1911/72014.

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Influenza A and B viruses are major causes of seasonal flu epidemics each year. Hemagglutinin (HA) mediates the binding of virus to host cell and the fusion with host membrane. The crystal of HA in complex with antibody that reveals the mechanism by which antibody recognizes HA may not diffract to high resolution, thereby preventing the accurate interpretation of the structural model. The application of normal mode refinement that aims for improving the structure quality at the low resolution is tested. These studies provide some guidelines for future refinement of HA-antibody complex struc

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