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Journal articles on the topic 'Inhibitio'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Kriti, Tripathi, and Anand Trivedi Dr. "A Study of Corrosion Inhibition of Urea and Thiourea on Carbon Steel in 2M Nitric Acid." International Journal of Recent Trends in Science Technology & Management(IJRTSTM) 2, no. 1 (2024): 1–10. https://doi.org/10.5281/zenodo.10865884.

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Steel has been tested for corrosion at 30°, 40°, 50° and 60° degrees Celsius in 2M nitric acid (HNO3). For the current investigation, six time periods ranging from one to six hours were selected. The corrosion rate of carbon steel in 2M nitric acid varies significantly with time and temperature under examination from 21.246 × 10-5 gram cm-2 min1 to 147.222 × 10-5gram cm-2 min1. The findings demonstrate that 3 has a significant impact on carbon steel corrosion at a concentration of 2M. Higher temperatures and longer exposure times have b

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2

Fowler, Christopher J., Gun Thorell, Margareta Andersson, and Olle Magnusson. "Is inhibitio of striatal synaptosomal tyrosine hydroxylation by dopamine agonists a measure of dopamine autoreceptor function?" Naunyn-Schmiedeberg's Archives of Pharmacology 331, no. 1 (1985): 12–19. http://dx.doi.org/10.1007/bf00498846.

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3

B., A. Baviskar, S. Khadabadi S., L. Deore S., and R. Shiradkar M. "Synthesis and anticancer evaluation of novel clubbed triazolyl indenoisoquinoline as topoisomerase I inhibitors." Journal of Indian Chemical Society Vol. 89, Nov 2012 (2012): 1557–64. https://doi.org/10.5281/zenodo.5771787.

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aovernment College of Pharmacy, Kathora Naka, Amravati-444 604, Maharashtra, India <em>E-mail </em>: bhushan _ baviskar@rediffmail.com Dr. Reddy's Laboratories, Ameerpet, Hyderabad, India <em>Manuscript received online 29 January 2012, revised 12 February 2012, accepted 18 February 2012</em> In continuation to our work for the development of new anticancer agents, novel clubbed triazolylindenoisoquinoline derivatives were synthesized in good yields and characterized by IR, <sup>1</sup>H NMR, mass spectral and elemental analyses. The prepared compounds were tested for their in vitro antican

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4

Nosaka, S., K. Inui, S. Murase, and K. Murata. "A prejunctional mechanism in midbrain periaqueductal gray inhibition of vagal bradycardia in rats." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 270, no. 2 (1996): R373—R382. http://dx.doi.org/10.1152/ajpregu.1996.270.2.r373.

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Stimulation of the dorsal part of the midbrain periaqueductal gray matter (dPAG) inhibits baroreflex vagal bradycardia (BVB) via a central mechanism. Here we report that the dPAG suppresses vagal bradycardia also by a peripheral mechanism. In chloralose-urethan-anesthetized, beta-blocked rats, the cervical vagus nerve was cut and the distal cut end was electrically stimulated to induce vagal bradycardia (VIB). Sustained electrical stimulation of the dPAG attenuated VIB in a duration-dependent manner but did not affect bradycardia induced by intravenous acetyl-choline (AIB). The dPAG inhibition

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5

Ninkovic, Jana, and Sabita Roy. "Chronic morphine modulates actin polymerization leading to inhibition of Fc-gamma receptor mediated phagocytosis (111.29)." Journal of Immunology 186, no. 1_Supplement (2011): 111.29. http://dx.doi.org/10.4049/jimmunol.186.supp.111.29.

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Abstract Morphine has been known to modulate innate immune functions, by inhibiting macrophage phagocytosis. However, mechanisms by which morphine inhibits macrophage phagocytic ability remain to be explained. Our results indicate that chronic morphine treatment in vitro and in vivo inhibited Fcγ receptor mediated phagocytosis in murine macrophages by inhibiting actin polymerization. Using fluorescence microscopy and fluorometry, we showed that chronic morphine treatment led to inhibition of actin polymerization resulting in impaired internalization of opsonized dextran beads. Chronic morphine

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6

OZ, Iris, Orna AVIDAN, and Amnon HIZI. "Inhibition of the integrases of human immunodeficiency viruses type 1 and type 2 by reverse transcriptases." Biochemical Journal 361, no. 3 (2002): 557–66. http://dx.doi.org/10.1042/bj3610557.

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We present evidence that the integrases (INs) of HIV types 1 and 2 are inhibited in vitro by the reverse transcriptases (RTs) of HIV-1, HIV-2 and murine leukaemia virus. Both 3′-end processing and 3′-end joining (strand transfer) activities of IN were affected by the RTs. Full inhibitions were accomplished with most RT and IN combinations tested at around equimolar RT/IN ratios. The disintegration activity of IN was also inhibited by RTs. Neither DNA synthesis nor the ribonuclease H (RNase H) domain of RT were involved in IN inhibition, since specific DNA polymerase inhibitors did not affect t

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7

Kimata, H., and A. Yoshida. "Differential effects of gangliosides on Ig production and proliferation by human B cells." Blood 84, no. 4 (1994): 1193–200. http://dx.doi.org/10.1182/blood.v84.4.1193.1193.

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Abstract The effects of gangliosides on human B-cell responses were studied. Of various gangliosides tested, only GM2 and GM3 inhibited production of IgG subclasses and IgM, but not IgA subclasses, and thymidine uptake by human B cells stimulated with SAC plus interleukin-2 (IL-2). In contrast, GM1, GD1a, GD1b, GD3, GT1b, and GQ1b were without effects. GM2- and GM3-induced inhibition were specific, because each was blocked by a corresponding antibody. Of various cytokines tested, tumor necrosis factor-alpha (TNF-alpha) alone counteracted GM2- and GM3- induced inhibitions of Ig production and t

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8

Kimata, H., and A. Yoshida. "Differential effects of gangliosides on Ig production and proliferation by human B cells." Blood 84, no. 4 (1994): 1193–200. http://dx.doi.org/10.1182/blood.v84.4.1193.bloodjournal8441193.

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The effects of gangliosides on human B-cell responses were studied. Of various gangliosides tested, only GM2 and GM3 inhibited production of IgG subclasses and IgM, but not IgA subclasses, and thymidine uptake by human B cells stimulated with SAC plus interleukin-2 (IL-2). In contrast, GM1, GD1a, GD1b, GD3, GT1b, and GQ1b were without effects. GM2- and GM3-induced inhibition were specific, because each was blocked by a corresponding antibody. Of various cytokines tested, tumor necrosis factor-alpha (TNF-alpha) alone counteracted GM2- and GM3- induced inhibitions of Ig production and thymidine

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9

McLeod, Brett N., and George B. Spiegelman. "Soj Antagonizes Spo0A Activation of Transcription in Bacillus subtilis." Journal of Bacteriology 187, no. 7 (2005): 2532–36. http://dx.doi.org/10.1128/jb.187.7.2532-2536.2005.

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ABSTRACT The ParA family protein Soj appears to negatively regulate sporulation in Bacillus subtilis by inhibiting transcription from promoters that are activated by phosphorylated Spo0A. We tested in vitro Soj inhibition of Spo0A-independent variants of a promoter that Soj inhibited (PspoIIG). Transcription from the variants was less sensitive to Soj inhibition, suggesting that inhibition of wild-type PspoIIG was linked to transcription activation by Spo0A.

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10

Gao, Xiang, Yuandan Zhang, Zhe Li, Xinmin Wang, and Yingna Du. "Study on synthesis and properties of polyacrylate wax inhibitor." Journal of Physics: Conference Series 2723, no. 1 (2024): 012013. http://dx.doi.org/10.1088/1742-6596/2723/1/012013.

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Abstract Synthesis and properties of polyacrylate ester paraffin inhibitior based on polyacrylate ester start from dodecanol, tetradecanol, hexadecanol, octadecanol respectively were introduced in this paper. Hexadecyl polyacrylic showed the most potent paraffin inhibition, and then the optimum reaction condition of it was ascertained. The percentage inhibition of hexadecyl polyacrylic, synthesized under the optimized conditions, reached to 79.3%. Then crosslinked polyacrylate ester paraffin inhibitiors were synthesized and screened by static wax precipitation experiment, and find the percenta

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11

Thorne, D. P., and T. D. Lockwood. "Four proteolytic processes of myocardium, one insensitive to thiol reactive agents and thiol protease inhibitor." American Journal of Physiology-Endocrinology and Metabolism 265, no. 1 (1993): E10—E19. http://dx.doi.org/10.1152/ajpendo.1993.265.1.e10.

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Four distinct processes mediating protein degradation were identified in the Langendorff perfused rat heart. Hearts were biosynthetically labeled in vitro with [3H]leucine for 10 min. The subsequent release of [3H]leucine at 1.5-min intervals (2 mM nonradioactive leucine) was determined from 20 min to 8 h after labeling in rhythmically contracting hearts. Rapid turnover proteins were eliminated during the first 3 h; this degradation was not inhibited by insulin (5 nM) or isoproterenol (0.5 microM). However, the nontoxic thiol reactive agent diamide (100 microM) caused a complete inhibition of

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12

Inatsu, Sakiko, Ayumi Ohsaki, and Kumiko Nagata. "Idebenone Acts against Growth of Helicobacter pylori by Inhibiting Its Respiration." Antimicrobial Agents and Chemotherapy 50, no. 6 (2006): 2237–39. http://dx.doi.org/10.1128/aac.01118-05.

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ABSTRACT Growth of Helicobacter pylori was inhibited by the quinones, idebenone, duroquinone, menadione, juglone, and coenzyme Q1 at low concentrations of 0.8 to 3.2 μg/ml. Idebenone specifically inhibited H. pylori growth by inhibiting respiration and decreasing the cellular ATP level. The respiratory inhibition was accompanied by reduction of idebenone by the H. pylori cells.

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13

Kim, Hyun Ji, Boram Kim, Hyung Jung Byun, et al. "Resolvin D1 Suppresses H2O2-Induced Senescence in Fibroblasts by Inducing Autophagy through the miR-1299/ARG2/ARL1 Axis." Antioxidants 10, no. 12 (2021): 1924. http://dx.doi.org/10.3390/antiox10121924.

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ARG2 has been reported to inhibit autophagy in vascular endothelial cells and keratinocytes. However, studies of its mechanism of action, its role in skin fibroblasts, and the possibility of promoting autophagy and inhibiting cellular senescence through ARG2 inhibition are lacking. We induced cellular senescence in dermal fibroblasts by using H2O2. H2O2-induced fibroblast senescence was inhibited upon ARG2 knockdown and promoted upon ARG2 overexpression. The microRNA miR-1299 suppressed ARG2 expression, thereby inhibiting fibroblast senescence, and miR-1299 inhibitors promoted dermal fibroblas

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14

Tapiainen, Terhi, Tero Kontiokari, Laura Sammalkivi, Irma Ikäheimo, Markku Koskela, and Matti Uhari. "Effect of Xylitol on Growth of Streptococcus pneumoniae in the Presence of Fructose and Sorbitol." Antimicrobial Agents and Chemotherapy 45, no. 1 (2001): 166–69. http://dx.doi.org/10.1128/aac.45.1.166-169.2001.

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ABSTRACT Xylitol is effective in preventing acute otitis media by inhibiting the growth of Streptococcus pneumoniae. To clarify this inhibition we used fructose, which is known to block similar growth inhibition observed in Streptococcus mutans. In addition, we evaluated the efficacy of sorbitol in inhibiting the growth of pneumococci, as sorbitol is widely used for indications similar to those for which xylitol is used. The addition of 5% xylitol to the growth medium resulted in marked growth inhibition, an effect which was totally eliminated in the presence of 1, 2.5, or 5% fructose but not

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15

Zhao, Qi, Mei Shan Pei, Wen Juan Guo, and Sheng Nian Wang. "Investigations of Adsorption of 1-Dodecyl-3-Methyl Imidazolium Chloride on Iron Surface as Corrosion Inhibitor." Advanced Materials Research 306-307 (August 2011): 1545–48. http://dx.doi.org/10.4028/www.scientific.net/amr.306-307.1545.

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1-dodecyl-3-methyl imidazolium chloride ([C12mim]Cl) was adsorbed on iron surface to form an inhibitive film. The adlayer inhibited the metal corrosion in 0.2 M H2SO4 efficiently. The inhibitive effect of [C12mim]Cl was characterized by electrochemical impedance spectroscopy (EIS) and scanning electron microscopy (SEM). Impedance spectra demonstrated that the values of charge-transfer resistance increased when adding [C12mim]Cl into 0.2 M H2SO4. The inhibition efficiency increased with increasing the concentration of [C12mim]Cl. Scanning electron microscopy (SEM) analysis showed that the corro

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16

Ocheretniuk, Alla, Oleksandr Kobzar, Iryna Mischenko, and Andriy Vovk. "N-Phenacylthiazolium Salts as Inhibitors of Cholinesterases." French-Ukrainian Journal of Chemistry 5, no. 2 (2017): 1–14. http://dx.doi.org/10.17721/fujcv5i2p1-14.

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Inhibition of acetylcholinesterase is considered as a promising approach for treatment of neurodegenerative disorders including Alzheimer's disease. In this study, we demonstrated that 5-substituted N-phenacylthiazolium derivatives are capable of inhibiting acetylcholinesterase and butyrylcholinesterase activities with IC50 values in the micromolar range. Some of the new thiazolium-based inhibitiors showed more than 10-fold selectivity for butyrylcholinesterase. Kinetic experiments and molecular docking were performed for understanding the inhibition mechanisms.

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17

Ali, Gul Shad, and A. S. N. Reddy. "Inhibition of Fungal and Bacterial Plant Pathogens by Synthetic Peptides: In Vitro Growth Inhibition, Interaction Between Peptides and Inhibition of Disease Progression." Molecular Plant-Microbe Interactions® 13, no. 8 (2000): 847–59. http://dx.doi.org/10.1094/mpmi.2000.13.8.847.

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Four synthetic cationic peptides, pep6, pep7, pep11 and pep20, were tested alone and in combinations for their antimicrobial activities against economically important plant pathogenic fungi (Phytophthora infestans and Alternaria solani) and bacteria (Erwinia carotovora subsp. carotovora and E. carotovora subsp. atroseptica). In in vitro studies, P. infestans and A. solani were inhibited by all four peptides, while E. carotovora subsp. carotovora and E. carotovora subsp. atroseptica were inhibited only by pep11 and pep20. All peptides completely inhibited P. infestans and A. solani on potato le

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18

Ji, Seung-Bae, So-Young Park, Subin Bae, et al. "Comprehensive Investigation of Stereoselective Food Drug Interaction Potential of Resveratrol on Nine P450 and Six UGT Isoforms in Human Liver Microsomes." Pharmaceutics 13, no. 9 (2021): 1419. http://dx.doi.org/10.3390/pharmaceutics13091419.

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The stereoselectivity of the food drug inhibition potential of resveratrol on cytochrome P450s and uridine 5′-diphosphoglucuronosyl transferases was investigated in human liver microsomes. Resveratrol enantiomers showed stereoselective inhibition of CYP2C9, CYP3A, and UGT1A1. The inhibitions of CYP1A2, CYP2B6, and CYP2C19 by resveratrol were stereo-nonselective. The estimated Ki values determined for CYP1A2 were 13.8 and 9.2 μM for trans- and cis-resveratrol, respectively. Trans-resveratrol noncompetitively inhibited CYP3A and UGT1A1 activities with Ki values of 23.8 and 27.4 μM, respectively.

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19

Williamson, Lauren, Itay Ayalon, Hui Shen, and Jennifer Kaplan. "Hepatic STAT3 inhibition amplifies the inflammatory response in obese mice during sepsis." American Journal of Physiology-Endocrinology and Metabolism 316, no. 2 (2019): E286—E292. http://dx.doi.org/10.1152/ajpendo.00341.2018.

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The purpose of this study was to better understand the role obesity plays in the inflammatory response during sepsis, specifically regarding the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway in the liver. We hypothesized that inhibiting STAT3 would lead to an increase in the inflammatory response and that obesity would amplify this effect. To investigate this, we inhibited STAT3 in two ways: pharmacological systemic inhibition and genetic hepatic-specific inhibition. In pharmacological inhibition studies, male C57BL/6 mice were randomized to a high-fat (60%

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20

Moodley, I., Y. Sotsios, and B. Bertin. "Modulation of oxazolone-induced hypersensitivity in mice by selective PDE inhibitors." Mediators of Inflammation 4, no. 2 (1995): 112–16. http://dx.doi.org/10.1155/s0962935195000196.

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The effects of PDE inhibitors on oxazolone-induced contact hypersensitivity (CS) were studied in mice. Rolipram, Ro 20-1724 and theophylline dose dependently inhibited CS but none caused >53% inhibition. ED30values at 24 h before challenge for rolipram, Ro 20-1724 and theophylline were 2.1, 5.4 and 30.4 mg/kg, p.o., respectively. Milrinone and SKF 94836 at 30 mg/kg caused a small, but significant inhibition of 13% and 18%, respectively, although the inhibition (8%) caused by zaprinast was not significant. Betamethasone (10 mg/kg, p.o.) caused a marked inhibition (80%) as did indomethacin (6

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Israeli, Tal, Yael Riahi, Perla Garzon та ін. "Nutrient Sensor mTORC1 Regulates Insulin Secretion by Modulating β-Cell Autophagy". Diabetes 71, № 3 (2021): 453–69. http://dx.doi.org/10.2337/db21-0281.

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The dynamic regulation of autophagy in β-cells by cycles of fasting-feeding and its effects on insulin secretion are unknown. In β-cells, mechanistic target of rapamycin complex 1 (mTORC1) is inhibited while fasting and is rapidly stimulated during refeeding by a single amino acid, leucine, and glucose. Stimulation of mTORC1 by nutrients inhibited the autophagy initiator ULK1 and the transcription factor TFEB, thereby preventing autophagy when β-cells were continuously exposed to nutrients. Inhibition of mTORC1 by Raptor knockout mimicked the effects of fasting and stimulated autophagy while i

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22

Oguzie, E. E. "Adsorption and corrosion inhibitive properties of Azadirachta indica in acid solutions." Pigment & Resin Technology 35, no. 6 (2006): 334–40. http://dx.doi.org/10.1108/03699420610711335.

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PurposeTo assess the protective effect and adsorption behaviour of Azadirachta indica extract in controlling mild steel corrosion in 1 M H2SO4 and 2 M HCl.Design/methodology/approachThe inhibitive effect of the plant extract was monitored using the gas‐volumetric technique. The inhibition mechanism was inferred by curve fitting of the experimental data to known adsorption isotherms and the trend of inhibition efficiency with temperature.FindingsAzadirachta indica extract effectively inhibited steel corrosion in the acid media studied by virtue of adsorption. The inhibitor adsorption characteri

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23

Zheng, Yifeng, Pengxi Liu, Neng Wang, et al. "Betulinic Acid Suppresses Breast Cancer Metastasis by Targeting GRP78-Mediated Glycolysis and ER Stress Apoptotic Pathway." Oxidative Medicine and Cellular Longevity 2019 (August 19, 2019): 1–15. http://dx.doi.org/10.1155/2019/8781690.

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Targeting aberrant metabolism is a promising strategy for inhibiting cancer growth and metastasis. Research is now geared towards investigating the inhibition of glycolysis for anticancer drug development. Betulinic acid (BA) has demonstrated potent anticancer activities in multiple malignancies. However, its regulatory effects on glycolysis and the underlying molecular mechanisms are still unclear. BA inhibited invasion and migration of highly aggressive breast cancer cells. Moreover, BA could suppress aerobic glycolysis of breast cancer cells presenting as a reduction of lactate production,

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24

Rether, Jan, Gerhard Erkel, Timm Anke та Olov Sterner. "Inhibition of inducible TNF-α expression by oxaspirodion, a novel spiro-compound from the ascomycete Chaetomium subspirale". Biological Chemistry 385, № 9 (2004): 829–34. http://dx.doi.org/10.1515/bc.2004.108.

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Abstract In a search for compounds inhibiting the inducible TNF-αa promoter activity in T cells, a new spiro-compound, designated oxaspirodion, was isolated from fermentations of the ascomycete Chaetomium subspirale. Oxaspirodion inhibited TNF-α promoter-driven luciferase reporter gene expression with an IC50 value of 2.5 µg/ml (10 µM) in TPA/ionomycin-stimulated Jurkat T cells. Studies on the mode of action of the compound revealed that the inhibition of the TNF-α promoter activity is caused by an inhibition of the phosphorylation of the ERK1/2 kinases. In addition, oxaspirodion inhibited the

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Bakri, Sophie J., Jeff Lynch, Michelle Howard-Sparks, Stephan Saint-Juste, and Said Saim. "Vorolanib, sunitinib, and axitinib: A comparative study of vascular endothelial growth factor receptor inhibitors and their anti-angiogenic effects." PLOS ONE 19, no. 6 (2024): e0304782. http://dx.doi.org/10.1371/journal.pone.0304782.

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Purpose Pathological angiogenesis and vascular instability are observed in diabetic retinopathy (DR), diabetic macular edema (DME), and wet age-related macular degeneration (wAMD). Many receptor tyrosine kinases (RTKs) including vascular endothelial growth factor receptors (VEGFRs) contribute to angiogenesis, whereas the RTK TIE2 is important for vascular stability. Pan-VEGFR tyrosine kinase inhibitors (TKIs) such as vorolanib, sunitinib, and axitinib are of therapeutic interest over current antibody treatments that target only one or two ligands. This study compared the anti-angiogenic potent

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26

Veyhl, Maike, Thorsten Keller, Valentin Gorboulev, Alexandra Vernaleken, and Hermann Koepsell. "RS1 (RSC1A1) regulates the exocytotic pathway of Na+-d-glucose cotransporter SGLT1." American Journal of Physiology-Renal Physiology 291, no. 6 (2006): F1213—F1223. http://dx.doi.org/10.1152/ajprenal.00068.2006.

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The product of gene RSC1A1, named RS1, participates in transcriptional and posttranscriptional regulation of the sodium-d-glucose cotransporter SGLT1. Using coexpression in oocytes of Xenopus laevis, posttranscriptional inhibition of human SGLT1 (hSGLT1) and some other transporters by human RS1 (hRS1) was demonstrated previously. In the present study, histidine-tagged hRS1 was expressed in oocytes or Sf9 cells and purified using nickel(II)-charged nitrilotriacetic acid-agarose. hRS1 protein was injected into oocytes expressing hSGLT1 or the human organic cation transporter hOCT2, and the effec

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Putnam, W. S., R. A. Liddle, and J. A. Williams. "Inhibitory regulation of rat exocrine pancreas by peptide YY and pancreatic polypeptide." American Journal of Physiology-Gastrointestinal and Liver Physiology 256, no. 4 (1989): G698—G703. http://dx.doi.org/10.1152/ajpgi.1989.256.4.g698.

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Peptide YY (PYY) and pancreatic polypeptide (PP) have been shown to inhibit exocrine pancreatic secretion in vivo in a variety of species. This study evaluates the type of stimulation inhibited by PYY and PP by examining, in urethan-anesthetized rats, the inhibition of pancreatic secretion when stimulated to a comparable extent by cholecystokinin (CCK), 2-deoxy-D-glucose (2DG), bethanecol, and electrical vagal nerve stimulation. PYY at maximal infusion rates inhibited stimulation by CCK by 83%, bethanecol by 55%, and electrical nerve stimulation by 40%. The inhibition of CCK stimulation was ha

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Lim, M. S., and M. P. Walsh. "The effects of caldesmon on the ATPase activities of rabbit skeletal-muscle myosin." Biochemical Journal 238, no. 2 (1986): 523–30. http://dx.doi.org/10.1042/bj2380523.

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We studied the effects of caldesmon, a major actin- and calmodulin-binding protein found in a variety of muscle and non-muscle tissues, on the various ATPase activities of skeletal-muscle myosin. Caldesmon inhibited the actin-activated myosin Mg2+-ATPase, and this inhibition was enhanced by tropomyosin. In the presence of the troponin complex and tropomyosin, caldesmon inhibited the Ca2+-dependent actomyosin Mg2+-ATPase; this inhibition could be partly overcome by Ca2+/calmodulin. Caldesmon, phosphorylated to the extent of approximately 4 mol of Pi/mol of caldesmon, inhibited the actin-activat

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29

Schwendicke, Falk, Franziska Korte, Christof E. Dörfer, Susanne Kneist, Karim Fawzy El-Sayed, and Sebastian Paris. "Inhibition of Streptococcus mutans Growth and Biofilm Formation by Probiotics in vitro." Caries Research 51, no. 2 (2017): 87–95. http://dx.doi.org/10.1159/000452960.

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To exert anticaries effects, probiotics are described to inhibit growth and biofilm formation of cariogenic bacteria such as Streptococcus mutans (SM). We screened 8 probiotics and assessed how SM growth or biofilm formation inhibition affects cariogenicity of probiotic-SM mixed-species biofilms in vitro. Growth inhibition was assessed by cocultivating probiotics and 2 SM strains (ATCC 20532/25175) on agar. Probiotics were either precultured before SM cultivation (exclusion), or SM precultured prior to probiotic cultivation (displacement). Inhibition of SM culture growth was assessed visually.

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Faizi, Shaheen, Tahira Sarfaraz, Saima Sumbul, et al. "Synthesis of Novel 8-Hydroxyquinoline Derivatives through Mannich Reaction and their Biological Evaluation as Potential Immunomodulatory Agents." Medicinal Chemistry 16, no. 4 (2020): 531–43. http://dx.doi.org/10.2174/1573406415666190626121650.

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Background: In continuation of our work on Mannich reaction on 8-hydroxyquinoline, fifteen different combinations of aromatic aldehydes and aniline were subjected to Mannich reaction from which twelve products (eight Mannich bases, two imines and two intramolecularly cyclized products with benzofuranone skeleton) were obtained. Among them six compounds (1, 2, 6, 8, 9 and 12) are the new compounds. The structures of the compounds were characterized by UV, IR, MS and 1H NMR. Method: The compounds were tested for the inhibition of pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and Int

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Singh, Pankaj Kumar, Raj Kumar, Ashok Sharma, et al. "Role of Apoptotic Proteins in REC-2006 Mediated Radiation Protection in Hepatoma Cell Lines." Evidence-Based Complementary and Alternative Medicine 2011 (2011): 1–11. http://dx.doi.org/10.1093/ecam/neq059.

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The present study was carried out to evaluate the role of apoptotic proteins in REC-2006-mediated radiation protection in hepatoma cell lines. REC-2006 treatment 2 h before irradiation strongly inhibited the cleavage of ATM and PARP-1 in HepG2 cells. The expression of nuclear apoptosis inducing factor (AIF) was found to be more inhibited (~17%) in HepG2 cells in REC-2006 + radiation-treated group. More inhibition (~33%) of cytochromecwas observed in HepG2 cells upon REC-2006 treatment 2 h prior irradiation. Similarly, significantly more (P<.05) inhibition of Apaf-1, caspase-9 and caspase-3

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Umoren, S. A., I. B. Obot, L. E. Akpabio, and S. E. Etuk. "Adsorption and corrosive inhibitive properties of Vigna unguiculata in alkaline and acidic media." Pigment & Resin Technology 37, no. 2 (2008): 98–105. http://dx.doi.org/10.1108/03699420810860455.

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PurposeTo investigate the adsorption behaviour and inhibitive effect of Vigna unguiculata (VU) extract (agricultural waste material) for aluminium corrosion in 0.5 M NaOH and H2SO4.Design/methodology/approachThe inhibitive effect of the plant extract was assessed using weight loss method at 30 and 60oC. The trend of inhibition efficiency with temperature was used to propose the mechanism of inhibition and type of adsorption.FindingsVU extract effectively inhibited aluminium corrosion in both alkaline and acidic media. Inhibition efficiency (I %) of the extract increased with increase in concen

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Mohanty, N., and HY Yamamoto. "Mechanism of Non-Photochemical Chlorophyll Fluorescence Quenching. I. The Role of De-Epoxidised Xanthophylls and Sequestered Thylakoid Membrane Protons as Probed by Dibucaine." Functional Plant Biology 22, no. 2 (1995): 231. http://dx.doi.org/10.1071/pp9950231.

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Dibucaine reportedly inhibits the light-induced transthylakoid proton gradient of chloroplasts without inhibiting energy-dependent non-photochemical chlorophyll fluorescence quenching (Laasch, H. and Weis, E. (1989). Photosynthesis Research 22, 137-146). We show that dibucaine can inhibit fluorescence quenching, depending on the de-epoxidation state of the xanthophyll cycle. Whereas dibucaine (20-40 μM) had little effect on fluorescence quenching in pre-illuminated-type thylakoids (loaded with zeaxanthin and antheraxanthin), it strongly inhibited quenching in dark-adapted-type thylakoids (no p

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34

Perollet, Catherine, Zhong Chao Han, Catherine Savona, Jacques Philippe Caen, and Andreas Bikfalvi. "Platelet Factor 4 Modulates Fibroblast Growth Factor 2 (FGF-2) Activity and Inhibits FGF-2 Dimerization." Blood 91, no. 9 (1998): 3289–99. http://dx.doi.org/10.1182/blood.v91.9.3289.

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AbstractPlatelet factor 4 (PF-4) inhibits angiogenesis in vitro and in vivo. The mechanism of inhibition is poorly understood. We have investigated the mechanism of inhibition by examining the interaction of PF-4 and the fibroblast growth factor-2 (FGF-2)/fibroblast growth factor receptor (FGFR) system. PF-4 inhibited the binding of FGF-2 to high-affinity and low-affinity binding sites in murine microvascular endothelial cells (LEII cells) and proliferation. Maximum inhibition of binding to endothelial FGF receptors was observed at PF-4 concentrations between 5 and 10 μg/mL (half maximum inhib

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Perollet, Catherine, Zhong Chao Han, Catherine Savona, Jacques Philippe Caen, and Andreas Bikfalvi. "Platelet Factor 4 Modulates Fibroblast Growth Factor 2 (FGF-2) Activity and Inhibits FGF-2 Dimerization." Blood 91, no. 9 (1998): 3289–99. http://dx.doi.org/10.1182/blood.v91.9.3289.3289_3289_3299.

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Platelet factor 4 (PF-4) inhibits angiogenesis in vitro and in vivo. The mechanism of inhibition is poorly understood. We have investigated the mechanism of inhibition by examining the interaction of PF-4 and the fibroblast growth factor-2 (FGF-2)/fibroblast growth factor receptor (FGFR) system. PF-4 inhibited the binding of FGF-2 to high-affinity and low-affinity binding sites in murine microvascular endothelial cells (LEII cells) and proliferation. Maximum inhibition of binding to endothelial FGF receptors was observed at PF-4 concentrations between 5 and 10 μg/mL (half maximum inhibition at

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Umemiya, M., and A. J. Berger. "Presynaptic inhibition by serotonin of glycinergic inhibitory synaptic currents in the rat brain stem." Journal of Neurophysiology 73, no. 3 (1995): 1192–201. http://dx.doi.org/10.1152/jn.1995.73.3.1192.

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1. With the use of a thin brain stem slice preparation, we recorded in visualized neonatal rat hypoglossal motoneurons unitary glycinergic inhibitory postsynaptic currents (IPSCs) that were evoked by extracellular stimulation of nearby interneurons. We found that 10 microM serotonin (5-HT) presynaptically inhibited this glycinergic synaptic transmission by 85.5%. 2. In the somata of presynaptic interneurons, 5-HT1A receptor activation potentiated inwardly rectifying K+ channels and inhibited voltage-activated calcium channels. 3. In contrast, the 5-HT1B receptor was primarily responsible for i

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Peeples, Eric S., Karoly Mirnics, and Zeljka Korade. "Chemical Inhibition of Sterol Biosynthesis." Biomolecules 14, no. 4 (2024): 410. http://dx.doi.org/10.3390/biom14040410.

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Cholesterol is an essential molecule of life, and its synthesis can be inhibited by both genetic and nongenetic mechanisms. Hundreds of chemicals that we are exposed to in our daily lives can alter sterol biosynthesis. These also encompass various classes of FDA-approved medications, including (but not limited to) commonly used antipsychotic, antidepressant, antifungal, and cardiovascular medications. These medications can interfere with various enzymes of the post-lanosterol biosynthetic pathway, giving rise to complex biochemical changes throughout the body. The consequences of these short-

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Wang, Hong Mei, Ke Long Huang, and Zhi Ping Zhu. "Corrosion Inhibition of Mild Steel by Benzotriazoliumionic Liquid in Hydrochloric Acid." Advanced Materials Research 239-242 (May 2011): 1409–13. http://dx.doi.org/10.4028/www.scientific.net/amr.239-242.1409.

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The inhibiting behavior of 1-ethyl-3-butylbenzotriazolium ionic liquids，[C2Bt][Br] ,on mild steel corrosion in 5 wt.% HCl as corroding solution was investigated using weight loss，potentiodynamic polarization and electrochemical impedance measurements. The obtained results indicated that [C2Bt][Br] is a good inhibitor for the mild steel in 5 wt.% HCl solution. The inhibition efficiency increased with an increase of inhibitive concentration. Potentiodynamic polarization data indicated that the [C2Bt][Br] acted essentially as a mixed-type inhibitor. The electrochemical impedance study showed that

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Rasmussen, F., J. Georgsen, and J. O. Pedersen. "Granulocyte Chemotaxis." Acta Radiologica 30, no. 1 (1989): 93–96. http://dx.doi.org/10.1177/028418518903000120.

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The under agarose method for evaluation of leucocyte chemotaxis was used to investigate the effect of radiographic contrast media (CM) on granulocyte locomotion. The CM tested had no chemoattractive properties. CM inhibited N-fmlp, a synthetic formylated Met-tripeptide, which is a strong chemotactic agent and an analogue to chemotatic peptides produced by bacteria. The inhibition of N-fmlp was most pronounced for diatrizoate. Equiosmolal saline was not so inhibitive. Therefore, some part of the inhibition was caused by factor(s) other than hyperosmolality inherent in the CM solution.

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De Silva, Deepa S., Richard M. Wilson, Christoph Hutchinson, et al. "Fenofibrate inhibits aldosterone-induced apoptosis in adult rat ventricular myocytes via stress-activated kinase-dependent mechanisms." American Journal of Physiology-Heart and Circulatory Physiology 296, no. 6 (2009): H1983—H1993. http://dx.doi.org/10.1152/ajpheart.00002.2009.

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Aldosterone induces extracellular signal-regulated kinase (ERK)-dependent cardiac remodeling. Fenofibrate improves cardiac remodeling in adult rat ventricular myocytes (ARVM) partly via inhibition of aldosterone-induced ERK1/2 phosphorylation and inhibition of matrix metalloproteinases. We sought to determine whether aldosterone caused apoptosis in cultured ARVM and whether fenofibrate ameliorated the apoptosis. Aldosterone (1 μM) induced apoptosis by increasing terminal deoxynucleotidyltransferase-mediated dUTP nick end labeling (TUNEL)-positive nuclei in ARVM. Spironolactone (100 nM), an ald

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Miya, Md Dulal, and Shamim Shamsi. "In Vitro Evaluation of Selected Plant extracts and Chemicals against Pathogenic Fungi isolated from Momordica Charantia L." Journal of Bangladesh Academy of Sciences 41, no. 1 (2017): 11–16. http://dx.doi.org/10.3329/jbas.v41i1.33496.

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Five plant extracts and two chemicals were evaluated against radial growth of five pathogenic fungi isolated from fresh vegetables of two varieties of Momordica charantia L. The isolated fungi were Aspergillus niger Van Tiegh, Curvularia brachyspora Boedijn, Fusarium Link, Rhizopus stolonifer (Ehrenb.:Fr.) Vuill and Trichoderma viride Pers.. Five plant extracts namely Allium sativum L., Azadirachta indicia A. Juss., Citrus limon (L.) Burm. f, Mangifera indica L. and Psidium guajava L. were evaluated for inhibiting growth of above mentioned fungi associated with the vegetable. Out of the five p

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Sanni, Omotayo, Jianwei Ren, and Tien-Chien Jen. "Surface and corrosion properties of Type 430 ferritic stainless steel in parsley (Petroselinum Sativum) essential oil-containing sulphuric acid solution." Surface Topography: Metrology and Properties 9, no. 4 (2021): 045050. http://dx.doi.org/10.1088/2051-672x/ac431f.

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Abstract This study examined the corrosion inhibiting properties of parsley (petroselinum sativum) essential oils, for Type 430 ferritic stainless steel in 0.5 molar sulphuric acid solutions. In this study, weight loss, electrochemical and scanning electron microscope techniques were used in gaining a detailed understanding of inhibition effects of parsley (petroselinum sativum) essential oils (PEO) on Type 430 ferritic stainless steel corrosion. The inhibitor studied exhibits good anti-corrosion performance with 98.65% inhibition efficiency. This result could be ascribed to the adsorbed PEO o

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Taylor, R. F., and L. P. Schramm. "Spinally mediated inhibition of abdominal and lumbar sympathetic activities." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 254, no. 4 (1988): R655—R658. http://dx.doi.org/10.1152/ajpregu.1988.254.4.r655.

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Renal, splenic, and lumbar sympathetic nerve activities were recorded in the paralyzed, anesthetized, artificially ventilated, and spinally transected rat. Electrical stimulation of the dorsolateral funiculus caudal to the spinal transection was used to generate stimulus-response curves for changes in sympathetic activity in each of the three sympathetic nerves using five stimulus frequencies. In all rats, spinal stimulation inhibited sympathetic activity in renal and splenogastric nerves by approximately 50%. In grouped data, threshold frequency for inhibition of renal and splenogastric sympa

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Mestry, Kaushik. "Schiff Bases as Potential Corrosion Inhibitor – A Review." International Journal of Advance and Applied Research 6, no. 25(C) (2025): 194–97. https://doi.org/10.5281/zenodo.15331569.

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Abstract: Corrosion is the destruction of metal which is a significant and costly issue across the world leads to drive much attention of researcher to find effective inhibitors. Schiff bases due to their versatile versatile structures and reactivity becoming a promising molecules as a corrosion inhibition. This review provides an insight regarding the role of Schiff bases as good corrosion inhibitor with emphasing on their structural features and inhibition mechanism. The review also explores the practical applications of Schiff bases in various industries and discusses the challenges and lim

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Komada, Hiroshi, Jun Uematsu, Sahoko Kihira, et al. "Inhibition of Human Parainfluenza Virus Type 2 Growth in Vitro by Catechin is caused by the Inhibition of Genome and mRNA Syntheses and by the Disruption of Cytoskeleton, and that by Tannic Acid is Mainly Caused by Genome Synthesis Inhibition and the Disruption of Cytoskeleton." International Journal of Sciences Volume 3, no. 2014-12 (2014): 47–55. https://doi.org/10.5281/zenodo.3348825.

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The antiviral activities of catechin mixture (catechin) and tannic acid against human parainfluenza virus type 2 (hPIV-2) were investigated in vitro. Catechin and tannic acid both inhibited cell fusion induced by hPIV-2 in LLCMK2 cells. However, high concentrations of them caused cell toxicity. Both catechin and tannic acid reduced the number of viruses released from the cells. Real time PCR showed that catechin almost completely inhibited virus genome RNA synthesis, and tannic acid largely inhibited it. Virus nucleoprotein (NP), fusion (F) and hemaggulutinin-neuraminidase (HN) gene syntheses

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Janthongkaw, Atikarn, Sirinthip Klaophimai, Tanaporn Khampaya, et al. "Effect of Green and Red Thai Kratom (Mitragyna speciosa) on pancreatic digestive enzymes (alpha-glucosidase and lipase) and acetyl-carboxylase 1 activity: A possible therapeutic target for obesity prevention." PLOS ONE 18, no. 9 (2023): e0291738. http://dx.doi.org/10.1371/journal.pone.0291738.

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Regular use of Thai kratom has been linked to reduced blood triglyceride levels and body mass index (BMI) in healthy individuals. We analyzed Green Thai Kratom (GTK) and Red Thai Kratom (RTK) to investigate their effects on pancreatic digestive enzymes. The ethanol extracts of GTK and RTK inhibited lipase activity more strongly than alpha-glucosidase activity, suggesting the presence of lipase inhibitors. Mitragynine, the major compound in GTK, showed potent lipase inhibition and moderate alpha-glucosidase inhibition. Quercetin, found in both extracts, strongly inhibited alpha-glucosidase but

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Mi, Siyuan, Jia Liu, Xiaojing Liu, Yishan Fu, Junjie Yi та Shengbao Cai. "Inhibitory Effects of Myricetrin and Dihydromyricetin toward α-Glucosidase and Pancreatic Lipase with Molecular Docking Analyses and Their Interaction". Journal of Food Quality 2021 (27 липня 2021): 1–10. http://dx.doi.org/10.1155/2021/9943537.

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The aim of the current study was to evaluate the interaction effects of myricetrin and dihydromyricetin in inhibiting α-glucosidase and pancreatic lipase at different combination ratios and concentrations and to illuminate the underlying mechanisms of their inhibitions by molecular docking analyses. Results showed that both phenolic compounds possessed good inhibitory effects toward two enzymes in a dose-dependent manner. Myricetrin demonstrated a stronger inhibition against α-glucosidase (IC50, 41.14 ± 2.52 and more than 200 μg/mL, respectively), while dihydromyricetin had a better pancreatic

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Elder, R. T., X. Xu, J. W. Williams, H. Gong, A. Finnegan, and A. S. Chong. "The immunosuppressive metabolite of leflunomide, A77 1726, affects murine T cells through two biochemical mechanisms." Journal of Immunology 159, no. 1 (1997): 22–27. http://dx.doi.org/10.4049/jimmunol.159.1.22.

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Abstract The immunosuppressive metabolite of leflunomide, A77 1726, inhibits the enzymatic activity of protein tyrosine kinases and of dihydro-orotic acid dehydrogenase, an enzyme involved in pyrimidine biosynthesis. Here murine CTLL cell lines were studied to determine which of the biochemical targets of A77 1726 was responsible for the observed inhibition of proliferation and cytotoxic activity. At low concentrations of A77 1726, pyrimidine biosynthesis is the target, since inhibition of proliferation correlates with a reduction in pyrimidine NTP levels and is reversed by uridine. At higher

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Huo, Ping Hui, Jian Feng Li, Shang Li Shi, et al. "Wide Spectrum Inhibitory Effect Study of Two Botanical Antimicrobials to Soil and Air Microbes." Applied Mechanics and Materials 310 (February 2013): 172–76. http://dx.doi.org/10.4028/www.scientific.net/amm.310.172.

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Two botanical antimicrobials: matrine and pyrethrin were used to study their wide spectrum inhibitory effect on microbes from air and soil, to compare their properties as effective inoculant additive. The result indicates that both the two antimicrobials have inhibited microbe number significantly as the increase of concentration contents, but stimulated microbe diameter. Matrine and pyrethrin have shown their superiority in inhibiting actinomycetes (completely inhibition concentration: 400 mg L-1 for air-oriented and 700mg L-1 for soil-oriented) and mould (completely inhibition concentration:

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Akhgari, A. B., M. Motallebi, and M. R. Zamani. "Bean polygalacturonase-inhibiting protein expressed in transgenic Brassica napus inhibits polygalacturonase from its fungal pathogen Rhizoctonia solani." Plant Protection Science 48, No. 1 (2012): 1–9. http://dx.doi.org/10.17221/46/2009-pps.

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Polygalacturonase-inhibiting proteins (PGIPs) selectively inhibit polygalacturonases (PGs) secreted by invading plant pathogenic fungi. The objective of present research was to clone and introduce the pgip2 gene from bean (Phaseolus vulgaris) cv. Goli, with antifungal potential, into the commercially important canola (Brassica napus, R line Hyola 308) via Agrobacterium tumefaciens mediated transformation. Here we used a transgenic overexpression approach in order to investigate the inhibitory activity of the PGIP on the PG from Rhizoctonia solani, the causal agent of damping off and root rot o

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