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Dissertations / Theses on the topic 'Integrin LFA-1'

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1

Stewart, Mairi Purslow. "Activation of the leukocyte integrin LFA-1 lymphocytes." Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321666.

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2

McDowall, Alison Jane. "Mechanisms of activation of the leukocyte integrin LFA-1." Thesis, Open University, 2000. http://oro.open.ac.uk/58066/.

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This work was undertaken to characterise the interaction of the leukocyterestricted integrin LFA-1 (CD1la/CD18) with its ligands. LFA-1 function is critical for an immune response and, for example, allows leukocyte binding and transmigration across the endothelium, antigen presentation and cytotoxic T lymphocyte-mediated killing. The ligands for LFA-1 are the Intercellular Adhesion Molecules (ICAMs), with ICAM-1, ICAM-2 and ICAM-3 being the best characterised. The binding sites on ICAM-1 and ICAM-3 for LFA-1 were investigated with the use of antibodies and mutated proteins. The following regio
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3

Stanley, Paula E. "The interaction between integrin LFA-1 and its ligand ICAM-1." Thesis, Open University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340738.

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4

Hedman, Håkan. "Regulation of leukocyte integrin adhesiveness." Doctoral thesis, Umeå universitet, Molekylärbiologi (Teknat- och Medfak), 1995. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-100597.

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5

Parks, William. "Force activation of I domain containing and lacking integrins on live cells." Thesis, Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/42695.

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Cellular adhesion plays a crucial role in the biological function of cells, allowing them to communicate and signal, as well as physically anchor, by enabling them to adhere to either other cells or the extra cellular matrix (ECM). This process is regulated by several factors including intrinsic bond kinetics, internal cellular signaling, environment, force exerted on the bond, and force history of the bond. Concerning the force and force history dependence, the observation of catch bonds in integrin binding has asked as more questions than it has answered. To explore the force and force hist
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6

Geginat, Jens. "Interdependence between adhesion and proliferation the role of the [alpha]L- [alphaL-], [beta]2-integrin [beta2-integrin] (LFA-1) in t cell antigen receptor dependent proliferation of primary human t lymphocytes /." [S.l.] : [s.n.], 1999. http://www.diss.fu-berlin.de/1999/35/index.html.

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7

Sirim, Pinar. "Funktionelle Charakterisierung der Signaltransduktionskaskade des LFA-1-Integrins." Diss., lmu, 2001. http://nbn-resolving.de/urn:nbn:de:bvb:19-3716.

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8

Lam, Hang-yee Chloe, and 林倖而. "Identification of interacting partners of LFA-1 in the testis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/202255.

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9

Sweeney, Bernadette Mary. "Activation of LFA-1 through mutations within the IDAS site of the I Domain : their effects on ligand binding and the capacity of LFA-1 to signal to other integrins." Thesis, Open University, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.402826.

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10

Birkigt, Jessica [Verfasser], Eugen [Gutachter] Feist, and Ulrike [Gutachter] Seifert. "Die Rolle von SLP-76 bei der T-Zellrezeptor-vermittelten Aktivierung des Integrins LFA-1 in T-Zellen / Jessica Birkigt ; Gutachter: Eugen Feist, Ulrike Seifert." Magdeburg : Universitätsbibliothek Otto-von-Guericke-Universität, 2020. http://d-nb.info/1223615677/34.

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11

Birkigt, Jessica Verfasser], Eugen [Gutachter] [Feist, and Ulrike [Gutachter] Seifert. "Die Rolle von SLP-76 bei der T-Zellrezeptor-vermittelten Aktivierung des Integrins LFA-1 in T-Zellen / Jessica Birkigt ; Gutachter: Eugen Feist, Ulrike Seifert." Magdeburg : Universitätsbibliothek Otto-von-Guericke-Universität, 2020. http://nbn-resolving.de/urn:nbn:de:gbv:ma9:1-1981185920-354499.

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12

Lopez, Nicola. "The integrin LFA-1 as a potential target for neutrophil interactions during neuroinflammation." Doctoral thesis, 2022. http://hdl.handle.net/11562/1066265.

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Neuroinflammation is a complex inflammatory process occurring within the central nervous system (CNS). It is mediated by the production of cytokines, chemokines, reactive oxygen species and secondary messengers produced and secreted by CNS-resident cells and recruited immune cells. Recent studies highlighted the key role of neutrophils as crucial players in chronic inflammatory diseases including CNS disorders such as Alzheimer’s disease (AD) and multiple sclerosis (MS). Previous studies on experimental autoimmune encephalomyelitis (EAE), the animal model of MS, have shown that neutrophils in
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13

Geginat, Jens [Verfasser]. "Interdependence between adhesion and proliferation : the role of the αL- [alphaL-], β2-integrin [beta2-integrin] (LFA-1) in t cell antigen receptor dependent proliferation of primary human t lymphocytes / von Jens Geginat". 1999. http://d-nb.info/962265039/34.

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14

Pietronigro, Enrica Caterina. "The role of neutrophils in the pathogenesis of Alzheimer's disease." Doctoral thesis, 2014. http://hdl.handle.net/11562/712180.

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L’Alzheimer è una severa e progressiva malattia neurodegenerativa età-dipendente, dalla eziologia sconosciuta. Colpisce 35 milioni di persone nel mondo e porta ad un deterioramento cognitivo, dovuto alla perdita neuronale in quelle regioni del cervello deputate all’apprendimento e alla memoria. Le due principali e distintive caratteristiche neuropatologiche della malattia di Alzheimer sono i depositi extracellulari di peptide beta-amiloide (placche) e i filamentosi aggregati intracellulari di proteina tau iperfosforilata. Recenti studi suggeriscono che la neuroinfiammazione può rappresentare u
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15

TOFFALI, Lara. "Identification of Jak PTK-regulated rho-specific GEFs involved in activation of lymphocyte adhesion." Doctoral thesis, 2013. http://hdl.handle.net/11562/546549.

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La rapida induzione dell’affinità integrinica è un processo dinamico cruciale nel reclutamento leucocitario, che è controllato da complessi meccanismi molecolari di segnale intracellulare indotti da chemochine. Le small GTPasi della famiglia di rho e rap sono certamente le molecole di segnale più studiate in questo contesto; dati recenti da noi ottenuti hanno evidenziato inoltre un ruolo importante delle proteine tirosin-chinasi della famiglia delle Jak (Jak PTKs) che agiscono da regolatori a monte delle small GTPasi. Gli scambiatori di nucleotidi guanosinici (GEFs-Guanosine Exchange Factors)
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16

DUSI, SILVIA. "Role of integrins in the trafficking of Th1 and Th17 cells in the central nervous system during experimental autoimmune encephalomyelitis." Doctoral thesis, 2017. http://hdl.handle.net/11562/961282.

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La Sclerosi Multipla (SM) è una patologia infiammatoria autoimmune cronica, disabilitante e demielinizzante, del sistema nervoso centrale (SNC). La migrazione di cellule T autoreattive e la loro riattivazione attraverso la presentazione antigenica effettuata dalle locali cellule presentanti l’antigene, rappresentano due eventi critici nella patogenesi della SM e nel suo modello animale, l’encefalite autoimmune sperimentale (EAE). Le risposte ai potenziali antigeni all’interno del SNC richiedono una migrazione a lungo raggio, comunicazione a corto raggio e contatti cellula-cellula diretti con l
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17

Sirim, Pinar [Verfasser]. "Funktionelle Charakterisierung der Signaltransduktionskaskade des LFA-1-Integrins / vorgelegt von Pinar Sirim." 2001. http://d-nb.info/962869317/34.

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