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Dissertations / Theses on the topic 'Interaction with biomolecule'

Author: Grafiati
Published: 5 June 2025
Last updated: 2 August 2025

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1

Kim, Jungseung. "Investigation of the Interactions between Biomolecules and Mesoporous Inorganic Materials in Biomolecule Immobilization for Bioseparation and Biocatalysis." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1318861345.

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2

Ringeard, Jean-Marie. "Synthèse de matériaux hybrides par procédé sol-gel : optimisation des interactions biomolécules-matrice." Thesis, Cergy-Pontoise, 2013. http://www.theses.fr/2013CERG0684.

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Le contrôle de la qualité des ressources en eau nécessite des outils de détection en continu et in situ. Dans ce contexte, les biocapteurs sont prometteurs dans le développement de nouveaux systèmes pour une détection précoce. On peut citer deux exemples dans des domaines aussi variés que la détection précoce de corrosion bactérienne ou la détection de la formation d'espèces biologiques responsables de maladies dégénératives.Ce travail propose la conception et la réalisation d'un biocapteur pour la détection de molécules d'intérêt biologiques. La réalisation de ce biocapteur est basée sur le d
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McPhail, Deborah. "Energetics of interaction between biomolecules." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363149.

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4

Bredenberg, Johan. "Modelling biomolecular interactions /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-571-9.

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5

Ipaud, Amandine Barbara. "Interaction of metal oxides with biomolecules." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 2014. http://digitalcommons.auctr.edu/dissertations/1312.

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Current methods utilized for the cleanup of drinking water primarily involve the use of chemical oxidants (e.g. chlorine, chlorine dioxide, ozone) to remove harmful bacteria and other pathogens. These processes create a number of disinfection by products (DBPs) that are potent toxins including halonitro-methanes and halo-acetic acids. In our research, we sought to examine the ability of supported metal oxides to accomplish disinfection without the production of toxic DBPs. In an effort to examine the interaction of bio-molecules with metal oxides surfaces, our group used Fourier transform infr
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6

Weibrecht, Irene. "Visualizing Interacting Biomolecules In Situ." Doctoral thesis, Uppsala universitet, Molekylära verktyg, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-151579.

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Intra- and intercellular information is communicated by posttranslational modifications (PTMs) and protein-protein interactions, transducing information over cell membranes and to the nucleus. A cells capability to respond to stimuli by several highly complex and dynamic signaling networks provides the basis for rapid responses and is fundamental for the cellular collaborations required in a multicellular organism. Having received diverse stimuli, being positioned at various stages of the cell cycle or, for the case of cancer, containing altered genetic background, each cell in a population is
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7

Lechelon, Mathias. "Long-range electrodynamic interactions among biomolecules." Thesis, Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0469/document.

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L’étude des organismes vivants, la biologie, s’étend sur de nombreux domaines et notamment s’applique à comprendre le fonctionnement des êtres vivants. Les organismes les plus complexes comme les êtres Humains possèdent plusieurs niveaux d’organisation : ils sont constitués successivement d’organes, de tissus, de cellules, de biomolécules. On trouve plusieurs types de biomolécules dont les protéines, qui sont comme des minuscules outils qui permettent aux cellules de vivre et d’interagir avec leur environnement. Pour cela, les protéines doivent entrer en contact les unes avec les autres de man
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Karlsson, Linda. "Biomolecular interactions with porous silicon /." Linköping : Univ, 2003. http://www.bibl.liu.se/liupubl/disp/disp2003/tek804s.pdf.

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9

Stocks, Matthew Benedict. "Interacting with biomolecules using haptic feedback." Thesis, University of East Anglia, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.539370.

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10

Tiwari, Purushottam Babu. "Multimode Analysis of Nanoscale Biomolecular Interactions." FIU Digital Commons, 2015. http://digitalcommons.fiu.edu/etd/1923.

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Biomolecular interactions, including protein-protein, protein-DNA, and protein-ligand interactions, are of special importance in all biological systems. These interactions may occer during the loading of biomolecules to interfaces, the translocation of biomolecules through transmembrane protein pores, and the movement of biomolecules in a crowded intracellular environment. The molecular interaction of a protein with its binding partners is crucial in fundamental biological processes such as electron transfer, intracellular signal transmission and regulation, neuroprotective mechanisms, and reg
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11

Lord, Megan Susan Graduate School of Biomedical Engineering Faculty of Engineering UNSW. "Biomolecular and cellular interactions with surfaces." Awarded by:University of New South Wales. Graduate School of Biomedical Engineering, 2006. http://handle.unsw.edu.au/1959.4/24213.

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The modulation of biological interactions with artificial surfaces is a vital aspect of biomaterials research. Protein adsorption is established as an early biological response to implanted materials that influences biocompatibility, hence an understanding of how to direct specific protein and cellular responses is critical for the development of future biomaterials. The effects of protein adsorption and subsequent cellular interactions on a variety of surfaces are investigated. Acrylic-based hydrogels are used as a model system in which to investigate both tear and serum protein adsorption
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12

Yan, Siu-cheong. "Bioinorganic chemistry of antimony : interaction of antimonial with biomolecules /." View the Table of Contents & Abstract, 2004. http://sunzi.lib.hku.hk/hkuto/record/B30575540.

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13

Yan, Siu-cheong, and 甄肇昌. "Bioinorganic chemistry of antimony: interaction of antimonial with biomolecules." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B4457017X.

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14

David, Laurent. "Modelisation des interactions electrostatiques des biomolecules en solution." Université Joseph Fourier (Grenoble), 1996. http://www.theses.fr/1996GRE10159.

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Les interactions electrostatiques jouent un role crucial dans la modelisation d'une macromolecule biologique, et particulierement dans la comprehension de l'effet du solvant sur le systeme considere. La resolution de l'equation lineaire de poisson-boltzmann (lpb) permet d'obtenir une representation de ces interactions. Plusieurs methodes resolvant cette equation (ou une approximation de cette equation) sont developpees dans le but d'etre utilisees en dynamique moleculaire. La premiere etude utilise la methode des differences finies pour discretiser le systeme et differents algorithmes mathemat
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15

Doutreligne, Sébastien. "interactive molecular dynamics software development : Application to biomolecule folding." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC180/document.

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Le repliement de biomolécules à partir de méthodes computationelles reste un grand défi. Plus particulièrement, les simulations de dynamique moléculaire tout-atomes sont intrinsèquement longues et ne permettent pas encore d’atteindre l’échelle de temps de la microseconde de façon courante. En général, un approche gros-grain est préférée pour simuler des systèmes plus grands et des échelles de temps plus longues. Les approches automatiques comme la dynamique moléculaire ne tiennent pas compte de l’expertise de l’investigateur. Ce travail de thèse explore le repliement des biomolécules au
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16

Anderson, Henrik. "Development of Electroacoustic Sensors for Biomolecular Interaction Analysis." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-107211.

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17

Honorato-Zimmer, Ricardo. "On a thermodynamic approach to biomolecular interaction networks." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28904.

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We explore the direct and inverse problem of thermodynamics in the context of rule-based modelling. The direct problem can be concisely stated as obtaining a set of rewriting rules and their rates from the description of the energy landscape such that their asymptotic behaviour when t → ∞ coincide. To tackle this problem, we describe an energy function as a finite set of connected patterns P and an energy cost function e which associates real values to each of these energy patterns. We use a finite set of reversible graph rewriting rules G to define the qualitative dynamics by showing which tr
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18

Batchelor, M. R. "Understanding and exploiting biomolecular interactions at interfaces." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596464.

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Force spectroscopy was used to measure adhesion forces between SAM-modified surfaces. A simple test system was investigated before applying the technique to the antibiotic, vancomycin, and its target cell-wall peptide sequence L-Lys-D-Ala-D-Ala. Unsuccessful attempts were made to investigate this interaction directly by coupling vancomycin to an AFM tip. Nonetheless, specific interaction forces were observed between two surfaces exposing L-Lys-D-Ala-D-Ala when vancomycin was present in the intervening solution. This has been ascribed to the initial formation of vancomycin/ L-Lys-D-Ala-D-Ala co
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19

Dryden, Daniel M. "Long-Range Interactions in Biomolecular-Inorganic Assemblies." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1405078771.

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20

MOTTA, STEFANO. "PROTEIN DYNAMICS SIMULATIONS TO INVESTIGATE BIOMOLECULAR INTERACTIONS." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2018. http://hdl.handle.net/10281/199135.

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Lo studio degli aspetti dinamici delle interazioni tra biomolecole è fondamentale per comprendere come queste molecole esercitano le loro funzioni nella cellula. La trasmissione di segnali cellulari, i processi di trasporto, la catalisi, sono funzioni che dipendono dall’interazione dinamica delle proteine con ormoni, farmaci e altre proteine. L’abilità di interazione delle proteine con altre molecole consente un ampio spettro di possibilità per la regolazione dei meccanismi biologici esistenti in natura. Un significativo avanzamento nello studio delle interazioni biomolecolari con metodi di di
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21

Iafisco, Michele <1980&gt. "Interaction between biomimetic inorganic materials and biomolecules: towards nanotechnological applications." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amsdottorato.unibo.it/1621/1/TESI_Michele_Iafisco.pdf.

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22

Iafisco, Michele <1980&gt. "Interaction between biomimetic inorganic materials and biomolecules: towards nanotechnological applications." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amsdottorato.unibo.it/1621/.

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23

Sethi, Manish. "INTERACTIONS AND EFFECTS OF BIOMOLECULES ON AU NANOMATERIAL SURFACES." UKnowledge, 2011. http://uknowledge.uky.edu/gradschool_diss/822.

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Au nanoparticles are increasingly being used in biological applications. Their use is of interest based upon their unique properties that are achieved at the nanoscale, which includes strong optical absorbances that are size and aggregation state dependent. Such absorbances can be used in sensitive chemical/biological detection schemes where bioligands can be directly attached to the nanoparticle surface using facile methods. Unfortunately, a number of complications persist that prevent their wide-scale use. These limitations include minimal nanoparticle stability in biological-based media of
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24

Moore, Adam. "On biomolecular interactions : investigating receptor-ligand interactions; theoretical and experimental approaches." Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298073.

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25

Mekapothula, Swapna. "Gold nanoparticle-biomolecule conjugates synthesis, properties, cellular interactions and cytotoxicity studies /." Diss., Columbia, Mo. : University of Missouri-Columbia, 2008. http://hdl.handle.net/10355/5641.

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Thesis (M.S.)--University of Missouri-Columbia, 2008.<br>"May 2008" The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Includes bibliographical references.
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26

Gargaun, Ana. "Capillary Electrophoresis for Separation of Biomolecules and Viruses." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/35235.

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This thesis examines the use of capillary electrophoresis for the study of several biomolecules and their interactions and viruses. The first two experimental chapters focus on its utility for thermodynamic and kinetic analysis of molecules. Chapter one focuses on the use of non-equilibrium capillary electrophoresis of equilibrium mixtures (NECEEM), to calculate the dissociation constant for the interaction between double stranded microRNA-122 and protein p19. NECEEM was used to calculate the rate constants (koff = 0.059 ± 0.013 s-1, kon = 0.0022 ± 0.0008 s-1M-1) and the dissociation cons
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27

Andersson, Karl. "Characterization of Biomolecular Interactions Using a Multivariate Approach." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4322.

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28

McKenzie, Fiona. "Nanoparticle probes for the study of biomolecular interactions." Thesis, University of Strathclyde, 2010. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=14371.

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29

Banwait, Sukraj Kaur. "Metallo-Supramolecular complexes and their interactions with biomolecules and cells." Thesis, University of Birmingham, 2010. http://etheses.bham.ac.uk//id/eprint/964/.

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Chapter 1 introduces the field of supramolecular chemistry and reviews examples of supramolecular architectures. Applications of these assemblies are outlined with a focus on DNA recognition. In chapter 2 the synthesis and characterisation of an array of palladium(II) and platinum(II) tetra-stranded, dinuclear complexes is described. The synthesis of two palladium(II) triangles and a palladium(II) pyramid are also presented. Chapter 3 investigates the biological activities of four of the tetra-stranded palladium(II) complexes described in chapter 2. The results show that while all of them bind
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30

Saha, Saumitra. "Spectral and orbital based analyses of interactions in some biomolecules /." Swinburne Research Bank, 2008. http://hdl.handle.net/1959.3/46099.

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Thesis (Ph. D.)--Swinburne University of Technology, Centre for Molecular Simulation - 2008.<br>Dissertation submitted in fulfilment of requirements for the degree Doctor of Philosophy, Centre for Molecular Simulation, Swinburne University of Technology, 2008. Typescript. Includes bibliographical references (p. 188-218).
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31

Li, Aixiao. "Molecular modeling of non-bonding interactions in biomolecules-ligand systems." Paris 7, 2009. http://www.theses.fr/2009PA077032.

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Ce travail est consacré à la modélisation des interactions entre des inhibiteurs et des molécules impliquées dans la cancérisation, dans le but notamment d'établir de manière précise les modes d'interaction biomolécules-ligand. Dans la famille des CDK (cyclin dépendant kinases) nous nous sommes intéressés à la sélectivité que présente un nouvel inhibiteur (2PU) vis-à-vis de CDK4 par rapport à CDK2. Les méthodes employées : dynamique moléculaire, calculs d'énergies d'interaction, docking et méthodes mixtes du type ONIOM ont permis d'établir les raisons précises de la sélectivité en mettant en é
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32

Imhoff, Marjorie. "Low-energy (1-500 eV) ion-biomolecule interactions in the condensed phase." Thèse, Université de Sherbrooke, 2005. http://savoirs.usherbrooke.ca/handle/11143/4208.

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An understanding of all nascent events leading to radiolytic DNA damage is required to achieve a complete description of ionizing radiation effects on living cells. These early, sub-picosecond events, involve the production of numerous low-energy (E < 20 eV) secondary electrons, neutral radicals, and secondary ions. Secondary ions, created either by the primary radiation, or by secondary electrons via resonant processes, are produced all along the primary radiation track with energies from a few eV up to several hundreds eV depending on their formation mechanism. Although much recent attention
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33

Xie, Mouzhe. "Probing and Modeling Biomolecule-Nanoparticle Interactions by Solution Nuclear Magnetic Resonance Spectroscopy." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1532049249287026.

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34

Sciortino, Giuseppe. "Understanding the interaction of metal complexes with their biomolecular targets." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/670180.

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Caracteritzar la interacció entre complexos de metalls de transició i proteïnes és fonamental en camps d’investigació com la farmacologia i la química mèdica i per al disseny de metal·loenzims artificials. La difracció de raigs-X i la ressonància magnètica nuclear (RMN) proporcionen una descripció estructural completa del sistema, encara que poden presentar-se dificultats que impedeixin la seva aplicació. Altres tècniques espectroscòpiques faciliten informació de la regió de la proteïna en la qual es troba enllaçat el complex metàl·lic, o del tipus de donadors que formen l’enllaç, però no perm
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35

Naemat, Abida. "Biomolecular imaging of host-pathogen interaction by Raman micro-spectroscopy." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/39476/.

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The ability of pathogens and their surrogate host cells to exchange molecules is at the core of all host-pathogen interaction processes. Small chemical molecule signals provide a rich vocabulary for cellular communication, and pathogens have evolved the capacity to modulate, mimic or hijack these signals in a defensive, exponentially increasing the scope and complexity of this chemical language between host cells and pathogens. The objective of this work is to use Raman microscopy (RMS) to analyze molecular changes during infection of human cells by intra- (Toxoplasma gondii) and extra-cellula
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36

Moro, Daniele <1979&gt. "Nanoscale surface properties and interaction with fundamental biomolecules of chlorite and phlogopite." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6352/1/Moro_Daniele_Tesi.pdf.

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The surface properties of minerals have important implications in geology, environment, industry and biotechnology and for certain aspects in the research on the origin of life. This research project aims to widen the knowledge on the nanoscale surface properties of chlorite and phlogopite by means of advanced methodologies, and also to investigate the interaction of fundamental biomolecules, such as nucleotides, RNA, DNA and amino acid glycine with the surface of the selected phyllosilicates. Multiple advanced and complex experimental approaches based on scanning probe microscopy and spatia
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Moro, Daniele <1979&gt. "Nanoscale surface properties and interaction with fundamental biomolecules of chlorite and phlogopite." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6352/.

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The surface properties of minerals have important implications in geology, environment, industry and biotechnology and for certain aspects in the research on the origin of life. This research project aims to widen the knowledge on the nanoscale surface properties of chlorite and phlogopite by means of advanced methodologies, and also to investigate the interaction of fundamental biomolecules, such as nucleotides, RNA, DNA and amino acid glycine with the surface of the selected phyllosilicates. Multiple advanced and complex experimental approaches based on scanning probe microscopy and spatia
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38

Rigby-Singleton, Shellie. "Scanning probe and optical tweezer investigations of biomolecular interactions." Thesis, University of Nottingham, 2003. http://eprints.nottingham.ac.uk/10001/.

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A complex array of intermolecular forces controls the interactions between and within biological molecules. The desire to empirically explore these fundamental forces has led to the development of several biophysical techniques. Of these, the atomic force microscope (AFM) and the optical tweezers have been employed throughout this thesis to monitor the intermolecular forces involved in biomolecular interactions. The AFM is a well-established force sensing technique capable of measuring biomolecular interactions at a single molecule level. However, its versatility has not been extrapolated to t
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Allen, Stephanie. "The study of biomolecular interactions using scanning probe microscopy." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363596.

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Dutt, Jodi Samantha Naomi. "Biomolecular interactions of whole blood constituents at amperometric electrodes." Thesis, University of Surrey, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.435171.

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Fong, Pedro. "Efficient and accurate prediction of biomolecular conformation and interactions." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.511262.

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Connors, Wendy Lee. "Sequential injection analysis for the investigation of biomolecular interactions /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/8481.

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PALMARA, GIANLUCA. "Microcantilever-based sensing arrays for evaluation of biomolecular interactions." Doctoral thesis, Politecnico di Torino, 2016. http://hdl.handle.net/11583/2639290.

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The controlled immobilization on a surface of biomolecules used as recognition elements is of fundamental importance in order to realize highly specific and sensible biosensors. Microcantilevers (MC) are nanomechanical sensors, which can be used as label free micro-sized mechanical transducers. MC resonant frequency is sensitively modified upon molecules adsorption, demonstrating an impressive mass resolution. A widely used approach for the immobilization of biorecognition elements on silicon substrates consists in the deposition of 3-aminopropyl-triethoxysilane (APTES) followed by the incubat
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Mareš, Jiří. "Structure, folding and interactions of membrane-associated biomolecules studied by NMR /." [S.l.] : [s.n.], 2009. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000286575.

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45

Wigenius, Jens. "Conjugated Polyelectrolytes in Interactions with Biomolecules for Supramolecular assembly and Sensing." Doctoral thesis, Linköpings universitet, Biomolekylär och Organisk Elektronik, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-54902.

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Conjugated polyelectrolytes (CP) show interesting electrical and optical properties for organic electronics as well as for life science applications. Their possibilities of supramolecular assembly with nanowire like misfolded proteins, amyloids, as well as synthetic polypeptides or DNA forming conducting or luminescent nano composites is highly interesting as being a truly bottom up approach for fabrication of OLEDs, photovoltaic’s as well as logic devices. The conformation and aggregation dependent luminescence properties from the special class of CPs, Luminescent conjugated polyelectrolytes
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46

Zyto, Aurore. "Computational modeling of protein-biomolecule interactions with application to mechanotransduction and antibody maturation." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/45207.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Biological Engineering Division, 2008.<br>Includes bibliographical references (leaves 100-112).<br>Cell survival, growth, differentiation, migration, and communication all depend on the appropriate combination of specific interactions between proteins and biomolecules. Therefore, understanding the molecular mechanisms influencing protein-biomolecule binding interactions is important both for fundamental knowledge and as a foundation for therapeutic applications and biotechnology. This thesis presents two applications of computational mode
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47

Demirgoez, Doene. "Surface plasmon fluorescence spectroscopy and microscopy studies for biomolecular interaction studies." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=976097044.

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48

Svedhem, Sofia. "Biomolecular interactions at model interfaces : a self-assembled monolayer approach /." Linköping : Univ, 2001. http://www.bibl.liu.se/liupubl/disp/disp2001/tek677s.pdf.

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49

Öster, Carl. "Investigating interactions using solid state NMR : applications to biomolecular complexes." Thesis, University of Warwick, 2017. http://wrap.warwick.ac.uk/99641/.

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Solid state NMR is a powerful method to obtain information on structure and dynamics of proteins, protein complexes, and other biomolecular assemblies, that due to solubility and size limitations cannot be achieved by other methods. This thesis is dedicated to the use of proton detected solid state NMR experiments at fast (60-100 kHz) magic angle spinning speeds to probe biomolecular structure, dynamics and intermolecular interactions. We used solvent paramagnetic relaxation enhancements to (i) speed up experiments and (ii) measure solvent accesibililty to map protein – protein interfaces. Fur
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50

Sanchez-Cano, Carlos. "Biomolecular interactions and cellular effects of steroidal and metallosupramolecular metallodrugs." Thesis, University of Birmingham, 2009. http://etheses.bham.ac.uk//id/eprint/494/.

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The work described herein concerns the effect on the anticancer activity and the ability to reach their possible intracellular targets of certain steroidal metallodrugs and metallosupramolecular cylinders. Chapter 1 surveys the background to the project, surveying different DNA-binding modes, explaining their importance in the anticancer properties of metallodrugs and showing an overview of the different strategies used for enhanced delivery of these metallodrugs. In Chapter 2 the synthesis of new steroidal DNA covalent-binding platinum(II) complexes together with techniques to purify previous
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