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Journal articles on the topic 'Interaction with biomolecule'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Zhou, Min, Weiping Li, Jian Li, et al. "Phase-separated condensate-aided enrichment of biomolecular interactions for high-throughput drug screening in test tubes." Journal of Biological Chemistry 295, no. 33 (2020): 11420–34. http://dx.doi.org/10.1074/jbc.ra120.012981.

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Modification-dependent and -independent biomolecular interactions, including protein–protein, protein–DNA/RNA, protein–sugar, and protein–lipid interactions, play crucial roles in all cellular processes. Dysregulation of these biomolecular interactions or malfunction of the associated enzymes results in various diseases; therefore, these interactions and enzymes are attractive targets for therapies. High-throughput screening can greatly facilitate the discovery of drugs for these targets. Here, we describe a biomolecular interaction detection method, called phase-separated condensate-aided enr

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2

Pronkin, Pavel G., and Alexander S. Tatikolov. "Photonics of Trimethine Cyanine Dyes as Probes for Biomolecules." Molecules 27, no. 19 (2022): 6367. http://dx.doi.org/10.3390/molecules27196367.

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Cyanine dyes are widely used as fluorescent probes in biophysics and medical biochemistry due to their unique photophysical and photochemical properties (their photonics). This review is focused on a subclass of the most widespread and studied cyanine dyes—trimethine cyanines, which can serve as potential probes for biomolecules. The works devoted to the study of the noncovalent interaction of trimethine cyanine dyes with biomolecules and changing the properties of these dyes upon the interaction are reviewed. In addition to the spectral-fluorescent properties, elementary photochemical propert

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Ekambaram, Rajasekaran, and Indupriya Rajasekaran. "Nanone interactions in antibody of living systems." Modern Health Science 4, no. 2 (2021): p1. http://dx.doi.org/10.30560/mhs.v4n2p1.

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One of the facts about how nanoparticle assemble and act is revealed using carbon value in biomolecule of living system here. This is how the biomolecules interact to bring about a micro or even macro level interaction in system of interest. This study shows micro level understanding can be better utilized from carbon analysis at nano level. I plan to extend this phenomena of change from nano to micro for building large scale applications in human nature. Applications include corrections in both at sequence and structure level for permanent recovery of defective one, adding flavor to the exist

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Zeindlhofer, Veronika, and Christian Schröder. "Computational solvation analysis of biomolecules in aqueous ionic liquid mixtures." Biophysical Reviews 10, no. 3 (2018): 825–40. http://dx.doi.org/10.1007/s12551-018-0416-5.

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Abstract Based on their tunable properties, ionic liquids attracted significant interest to replace conventional, organic solvents in biomolecular applications. Following a Gartner cycle, the expectations on this new class of solvents dropped after the initial hype due to the high viscosity, hydrolysis, and toxicity problems as well as their high cost. Since not all possible combinations of cations and anions can be tested experimentally, fundamental knowledge on the interaction of the ionic liquid ions with water and with biomolecules is mandatory to optimize the solvation behavior, the biode

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Chen, Jiajie, Youjun Zeng, Jie Zhou, et al. "Optothermophoretic flipping method for biomolecule interaction enhancement." Biosensors and Bioelectronics 204 (May 2022): 114084. http://dx.doi.org/10.1016/j.bios.2022.114084.

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Rowe, Rhianon K., and P. Shing Ho. "Relationships between hydrogen bonds and halogen bonds in biological systems." Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials 73, no. 2 (2017): 255–64. http://dx.doi.org/10.1107/s2052520617003109.

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The recent recognition that halogen bonding (XB) plays important roles in the recognition and assembly of biological molecules has led to new approaches in medicinal chemistry and biomolecular engineering. When designing XBs into strategies for rational drug design or into a biomolecule to affect its structure and function, we must consider the relationship between this interaction and the more ubiquitous hydrogen bond (HB). In this review, we explore these relationships by asking whether and how XBs can replace, compete against or behave independently of HBs in various biological systems. The

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Chaudhary, M., and K. Tyagi. "A REVIEW ON MOLECULAR DOCKING AND ITS APPLICATION." International Journal of Advanced Research 12, no. 03 (2024): 1141–53. http://dx.doi.org/10.21474/ijar01/18505.

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Molecular Docking is powerful computer strategy, critical in drug development, structural biology, and biomolecular interaction researchproviding a thorough grasp of its importance in modern scientific study. Molecular docking involves forecasting how a small molecule, often a potential medication, will interact with a target biomolecule like DNA or a protein. This process examines the spatial and energetic compatibility of the ligand with the active site of the receptor, assisting in the discovery of new drug candidates, refining existing compounds, and understanding the intricate interaction

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Fraikin, G. Ya. "Photosensitized reactions of oxidative damage to biomolecules: role in genotoxic and cytotoxic processes." Vestnik Moskovskogo universiteta. Seria 16. Biologia 79, no. 3, 2024 (2024): 167–83. https://doi.org/10.55959/msu0137-0952-16-79-3-1.

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Photosensitized oxidation reactions of biomolecules such as lipids, proteins, DNA initiate cytotoxic and genotoxic processes that are mediated by endogenous sensitizers under effect of ultraviolet radiation in the range A (UVA, 320–400 nm) on living systems. The photosensitization reactions are oxygen-dependent and depending upon primary mechanism are divided into type I and type II. Type I reactions involve electron transfer between photoexcited sensitizer and biomolecule with the formation of radical states. The interaction of radical cation of biomolecule with oxygen leads to the production

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Zhuravlova, Maryna, Nataliya Obernikhina, Stepan Pilyo, Maryna Kachaeva, Oleksiy Kachkovsky, and Volodymyr Brovarets. "In silico binding affinity studies of phenyl-substituted 1,3-oxazoles with protein molecules." Ukr. Bioorg. Acta 2020, Vol. 15, N1 15, no. 1 (2020): 12–19. http://dx.doi.org/10.15407/bioorganica2020.01.012.

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The new model approach of interaction between the pharmacophores with bio-molecules, fragment-to-fragment, is presented. It is a new step of the molecular modeling and takes correctly into consideration not only the spatial complementarity of the interacted molecules but also the contribution of the stacking π-π-electron interaction and hydrogen bonds. As an example, the correct analysis of the interaction of the biological active phenyl-substituted 1,3-oxazoles with protein fragments is performed. It was shown that the length and energy of the hydrogen bond uniquely depend on the chemical con

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Hatamipour, Mahdi, Thomas P. Johnston, and Amirhossein Sahebkar. "One Molecule, Many Targets and Numerous Effects: The Pleiotropy of Curcumin Lies in its Chemical Structure." Current Pharmaceutical Design 24, no. 19 (2018): 2129–36. http://dx.doi.org/10.2174/1381612824666180522111036.

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Curcumin quite possibly represents one of the most diverse therapeutic agents yet isolated from natural sources. Therapeutic benefits of this extraordinary natural compound have been demonstrated during treatment of a variety of diseases, including cancer, inflammatory processes, immunological disorders, Diabetes, and oxidative stress often associated with hyperlipidemia. Due to its unique molecular chemical structure and functional groups, curcumin may bind with and subsequently either inhibit or activate a variety of endogenous biomolecules, including enzymes, receptors, signaling molecules,

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Nawaz, Nighat, Roshan Ali, Muhammad Ali, et al. "Microscale Thermophoresis Analysis of Membrane Proteins." Chemical Science International Journal 33, no. 2 (2024): 25–45. http://dx.doi.org/10.9734/csji/2024/v33i2887.

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Microscale thermophoresis (MST) is an analytical technique for measuring biomolecular interactions. It is based on the physical phenomenon that particles move within temperature gradients, which is affected by their size, charge, hydration shell and conformation. The MST sample must contain a fluorescent target molecule used to observe the movement of particles, and this can be titrated with an unlabelled binding partner for quantifying the interaction. MST is highly sensitive, using relatively small amounts of sample, and it has no limitations on the size of the target biomolecule, on the aff

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Polash, Shakil Ahmed, Koen Garlick-Trease, Suneela Pyreddy, Selvakannan Periasamy, Gary Bryant, and Ravi Shukla. "Amino Acid-Coated Zeolitic Imidazolate Framework for Delivery of Genetic Material in Prostate Cancer Cell." Molecules 28, no. 12 (2023): 4875. http://dx.doi.org/10.3390/molecules28124875.

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Metal–organic frameworks (MOFs) are currently under progressive development as a tool for non-viral biomolecule delivery. Biomolecules such as proteins, lipids, carbohydrates, and nucleic acids can be encapsulated in MOFs for therapeutic purposes. The favorable physicochemical properties of MOFs make them an attractive choice for delivering a wide range of biomolecules including nucleic acids. Herein, a green fluorescence protein (GFP)-expressing plasmid DNA (pDNA) is used as a representative of a biomolecule to encapsulate within a Zn-based metal–organic framework (MOF) called a zeolitic imid

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Mishra, Esha, Subrata Majumder, Shikha Varma, and Peter A. Dowben. "X-ray photoemission studies of the interaction of metals and metal ions with DNA." Zeitschrift für Physikalische Chemie 236, no. 4 (2021): 439–80. http://dx.doi.org/10.1515/zpch-2021-3037.

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Abstract X-ray Photoelectron Spectroscopy (XPS) has been used to study the interactions of heavy metal ions with DNA with some success. Surface sensitivity and selectivity of XPS are advantageous for identifying and characterizing the chemical and elemental structure of the DNA to metal interaction. This review summarizes the status of what amounts to a large part of the photoemission investigations of biomolecule interactions with metals and offers insight into the mechanism for heavy metal-bio interface interactions. Specifically, it is seen that metal interaction with DNA results in conform

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Pandey, Gyanendra Krishna, Nilesh Kumar Pathak, R. Uma, and R. P. Sharma. "Electromagnetic study of surface enhanced Raman scattering of plasmonic-biomolecule: An interaction between nanodimer and single biomolecule." Solid State Communications 255-256 (April 2017): 47–53. http://dx.doi.org/10.1016/j.ssc.2017.03.010.

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15

Myndrul, Valerii, and Igor Iatsunskyi. "Nanosilicon-Based Composites for (Bio)sensing Applications: Current Status, Advantages, and Perspectives." Materials 12, no. 18 (2019): 2880. http://dx.doi.org/10.3390/ma12182880.

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This review highlights the application of different types of nanosilicon (nano-Si) materials and nano-Si-based composites for (bio)sensing applications. Different detection approaches and (bio)functionalization protocols were found for certain types of transducers suitable for the detection of biological compounds and gas molecules. The importance of the immobilization process that is responsible for biosensor performance (biomolecule adsorption, surface properties, surface functionalization, etc.) along with the interaction mechanism between biomolecules and nano-Si are disclosed. Current tre

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John, Torsten, Zhi Xiang Voo, Clemens Kubeil, et al. "Effects of guanidino modified aminoglycosides on mammalian membranes studied using a quartz crystal microbalance." MedChemComm 8, no. 5 (2017): 1112–20. http://dx.doi.org/10.1039/c7md00054e.

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17

Geng, Lijun, Xudong Yu, Yajuan Li, et al. "Instant hydrogel formation of terpyridine-based complexes triggered by DNA via non-covalent interaction." Nanoscale 11, no. 9 (2019): 4044–52. http://dx.doi.org/10.1039/c8nr08532c.

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Ding, Pingjian, Wenjue Ouyang, Jiawei Luo, and Chee-Keong Kwoh. "Heterogeneous information network and its application to human health and disease." Briefings in Bioinformatics 21, no. 4 (2019): 1327–46. http://dx.doi.org/10.1093/bib/bbz091.

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Abstract The molecular components with the functional interdependencies in human cell form complicated biological network. Diseases are mostly caused by the perturbations of the composite of the interaction multi-biomolecules, rather than an abnormality of a single biomolecule. Furthermore, new biological functions and processes could be revealed by discovering novel biological entity relationships. Hence, more and more biologists focus on studying the complex biological system instead of the individual biological components. The emergence of heterogeneous information network (HIN) offers a pr

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PIERRES, ANNE, JOANA VITTE, ANNE-MARIE BENOLIEL, and PIERRE BONGRAND. "DISSECTING INDIVIDUAL LIGAND–RECEPTOR BONDS WITH A LAMINAR FLOW CHAMBER." Biophysical Reviews and Letters 01, no. 03 (2006): 231–57. http://dx.doi.org/10.1142/s1793048006000161.

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The most important function of proteins may well be to bind to other biomolecules. It has long been felt that kinetic rates of bond formation and dissociation between soluble receptors and ligands might account for most features of the binding process. Only theoretical considerations allowed to predict the behaviour of surface-attached receptors from the properties of soluble forms. During the last decade, experimental progress essentially based on flow chambers, atomic force microscopes or biomembrane force probes allowed direct analysis of biomolecule interaction at the single bond level and

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Kusnin, Norzila, Nor Azah Yusof, Nurul Asyikeen Ab Mutalib, et al. "Enhanced Electrochemical Conductivity of Surface-Coated Gold Nanoparticles/Copper Nanowires onto Screen-Printed Gold Electrode." Coatings 12, no. 5 (2022): 622. http://dx.doi.org/10.3390/coatings12050622.

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Electrochemical application has been widely used in the study of biosensors. Small biomolecules need a sensitive sensor, as the transducer that can relay the signal produced by biomolecule interactions. Therefore, we are improvising a sensor electrode to enhance electrochemical conductivity for the detection of small DNA molecule interaction. This work describes the enhanced electrochemical conductivity studies of copper nanowires/gold nanoparticles (CuNWs/AuNPs), using the screen-printed gold electrode (SPGE). The AuNPs were synthesized using the Turkevich method as well as characterized by t

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21

Zhang, Wenhao, and Tiechao Jiang. "Design of Biomolecule Interaction Detection System Based on Fiber Biosensor." IEEE Sensors Journal 20, no. 16 (2020): 8922–29. http://dx.doi.org/10.1109/jsen.2020.2984808.

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22

Plikusiene, Ieva, Vincentas Maciulis, Arunas Ramanavicius, and Almira Ramanaviciene. "Spectroscopic Ellipsometry and Quartz Crystal Microbalance with Dissipation for the Assessment of Polymer Layers and for the Application in Biosensing." Polymers 14, no. 5 (2022): 1056. http://dx.doi.org/10.3390/polym14051056.

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Polymers represent materials that are applied in almost all areas of modern life, therefore, the characterization of polymer layers using different methods is of great importance. In this review, the main attention is dedicated to the non-invasive and label-free optical and acoustic methods, namely spectroscopic ellipsometry (SE) and quartz crystal microbalance with dissipation (QCM-D). The specific advantages of these techniques applied for in situ monitoring of polymer layer formation and characterization, biomolecule immobilization, and registration of specific interactions were summarized

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Wieland, Felicia, Richard Bruch, Michael Bergmann, Stefan Partel, Gerald A. Urban, and Can Dincer. "Enhanced Protein Immobilization on Polymers—A Plasma Surface Activation Study." Polymers 12, no. 1 (2020): 104. http://dx.doi.org/10.3390/polym12010104.

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Over the last years, polymers have gained great attention as substrate material, because of the possibility to produce low-cost sensors in a high-throughput manner or for rapid prototyping and the wide variety of polymeric materials available with different features (like transparency, flexibility, stretchability, etc.). For almost all biosensing applications, the interaction between biomolecules (for example, antibodies, proteins or enzymes) and the employed substrate surface is highly important. In order to realize an effective biomolecule immobilization on polymers, different surface activa

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Giampà, Marco, and Elvira Sgobba. "Insight to Functional Conformation and Noncovalent Interactions of Protein-Protein Assembly Using MALDI Mass Spectrometry." Molecules 25, no. 21 (2020): 4979. http://dx.doi.org/10.3390/molecules25214979.

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Noncovalent interactions are the keys to the structural organization of biomolecule e.g., proteins, glycans, lipids in the process of molecular recognition processes e.g., enzyme-substrate, antigen-antibody. Protein interactions lead to conformational changes, which dictate the functionality of that protein-protein complex. Besides biophysics techniques, noncovalent interaction and conformational dynamics, can be studied via mass spectrometry (MS), which represents a powerful tool, due to its low sample consumption, high sensitivity, and label-free sample. In this review, the focus will be pla

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Saha, S., S. Sur, A. K. Bothra, and Arnab Sen. "A homology model of 16s rRNA tertiary structure of Frankia." NBU Journal of Plant Sciences 6, no. 1 (2012): 89–94. http://dx.doi.org/10.55734/nbujps.2012.v06i01.014.

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Tertiary structure determination of biomolecule is important for knowing their function. Although different experimental prediction methods are present computational approach has an important role. Frankia sp., is a nitrogen fixing bacterium promoting soil fertility.16S ribosomal nucleic acid molecule is not only important as a molecular signature for classification and identification of organisms but has a great impact on protein synthesis. Here we have developed 3D structure of 16S rRNA of three different strains of Frankia viz Frankia sp. strain HFPCc13, Frankia alni strain ACN14a and Frank

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Baltoumas, Fotis A., Sofia Zafeiropoulou, Evangelos Karatzas, et al. "Biomolecule and Bioentity Interaction Databases in Systems Biology: A Comprehensive Review." Biomolecules 11, no. 8 (2021): 1245. http://dx.doi.org/10.3390/biom11081245.

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Technological advances in high-throughput techniques have resulted in tremendous growth of complex biological datasets providing evidence regarding various biomolecular interactions. To cope with this data flood, computational approaches, web services, and databases have been implemented to deal with issues such as data integration, visualization, exploration, organization, scalability, and complexity. Nevertheless, as the number of such sets increases, it is becoming more and more difficult for an end user to know what the scope and focus of each repository is and how redundant the informatio

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Jebakumari, K. A. Esther, N. K. Murugasenapathi, and Tamilarasan Palanisamy. "Engineered Two-Dimensional Nanostructures as SERS Substrates for Biomolecule Sensing: A Review." Biosensors 13, no. 1 (2023): 102. http://dx.doi.org/10.3390/bios13010102.

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Two-dimensional nanostructures (2DNS) attract tremendous interest and have emerged as potential materials for a variety of applications, including biomolecule sensing, due to their high surface-to-volume ratio, tuneable optical and electronic properties. Advancements in the engineering of 2DNS and associated technologies have opened up new opportunities. Surface-enhanced Raman scattering (SERS) is a rapid, highly sensitive, non-destructive analytical technique with exceptional signal amplification potential. Several structurally and chemically engineered 2DNS with added advantages (e.g., π–π*

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Garrain, P.-A., D. Costa, and P. Marcus. "Biomaterial−Biomolecule Interaction: DFT-D Study of Glycine Adsorption on Cr2O3." Journal of Physical Chemistry C 115, no. 3 (2010): 719–27. http://dx.doi.org/10.1021/jp109704b.

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Platts, James A., and Iogann Tolbatov. "Simulation of uranyl-biomolecule interaction using a cationic dummy atom model." Chemical Physics Letters 822 (July 2023): 140479. http://dx.doi.org/10.1016/j.cplett.2023.140479.

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Li, Hui Qing, Xiu Fang Wang, Jun Zhang, and Xiao Wei Di. "Investigating the Interaction Mechanism of Gold Nanoparticles with Mercapto Amino Acids." Advanced Materials Research 645 (January 2013): 43–46. http://dx.doi.org/10.4028/www.scientific.net/amr.645.43.

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Biomolecule functionalized gold nanoparticles offer a broad range of applications in biomedical and bioanalytical areas. In this work, we investigated the spectroscopy behavior of gold nanoparticles modified with mercapto amino acid, cysteine. We found that the interaction of gold nanoparticles with cysteine resulted in a shift in the plasmon bands to higher wavelengths at the lower concentration of cysteine and in acidity solution.

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Kim, Hokyung, Hayeon Choi, Yoonji Heo, Cheoljae Kim, Min Kim, and Ki Tae Kim. "Biosensors Based on Bivalent and Multivalent Recognition by Nucleic Acid Scaffolds." Applied Sciences 12, no. 3 (2022): 1717. http://dx.doi.org/10.3390/app12031717.

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Several biological macromolecules adopt bivalent or multivalent interactions to perform various cellular processes. In this regard, the development of molecular constructs presenting multiple ligands in a specific manner is becoming crucial for the understanding of multivalent interactions and for the detection of target macromolecules. Nucleic acids are attractive molecules to achieve this goal because they are capable of forming various, structurally well-defined 2D or 3D nanostructures and can bear multiple ligands on their structures with precisely controlled ligand–ligand distances. Thank

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Hymavati, Vivek Kumar, and M. Elizabeth Sobhia. "Implication of Crystal Water Molecules in Inhibitor Binding at ALR2 Active Site." Computational and Mathematical Methods in Medicine 2012 (2012): 1–11. http://dx.doi.org/10.1155/2012/541594.

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Water molecules play a crucial role in mediating the interaction between a ligand and a macromolecule. The solvent environment around such biomolecule controls their structure and plays important role in protein-ligand interactions. An understanding of the nature and role of these water molecules in the active site of a protein could greatly increase the efficiency of rational drug design approaches. We have performed the comparative crystal structure analysis of aldose reductase to understand the role of crystal water in protein-ligand interaction. Molecular dynamics simulation has shown the

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Nelea, Valentin, Jeanne Paquette, and Marc D. McKee. "Mechanisms of Interaction of Biomolecule Phosphate Side Chains with Calcite during Dissolution." Crystal Growth & Design 21, no. 5 (2021): 2898–910. http://dx.doi.org/10.1021/acs.cgd.1c00082.

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Jung, Yong Woo, Jae Jin Yoon, Young Dong Kim, and Deokha Woo. "Study of the Interaction Between Biomolecule Monolayers Using Total Internal Reflection Ellipsometry." Journal of the Korean Physical Society 58, no. 4(2) (2011): 1031–34. http://dx.doi.org/10.3938/jkps.58.1031.

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Rogoża, Natalia H., Magdalena A. Krupa, Pawel Krupa, and Adam K. Sieradzan. "Integrating Explicit and Implicit Fullerene Models into UNRES Force Field for Protein Interaction Studies." Molecules 29, no. 9 (2024): 1919. http://dx.doi.org/10.3390/molecules29091919.

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Fullerenes, particularly C60, exhibit unique properties that make them promising candidates for various applications, including drug delivery and nanomedicine. However, their interactions with biomolecules, especially proteins, remain not fully understood. This study implements both explicit and implicit C60 models into the UNRES coarse-grained force field, enabling the investigation of fullerene–protein interactions without the need for restraints to stabilize protein structures. The UNRES force field offers computational efficiency, allowing for longer timescale simulations while maintaining

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Cueto-Díaz, Eduardo J., Santos Gálvez-Martínez, María Colin-García, and Eva Mateo-Martí. "A New Approach in Prebiotic Chemistry Studies: Proline Sorption Triggered by Mineral Surfaces Analysed Using XPS." Life 13, no. 4 (2023): 908. http://dx.doi.org/10.3390/life13040908.

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The role of minerals in the origin of life and prebiotic evolution remains unknown and controversial. Mineral surfaces have the potential to facilitate prebiotic polymerization due to their ability to adsorb and concentrate biomolecules that subsequently can catalyse reactions; however, the precise nature of the interaction between the mineral host and the guest biomolecule still needs to be understood. In this context, we spectroscopically characterized, using infrared, X-ray photoemission spectroscopy (XPS) and X-ray diffraction (XRD) techniques, the interaction between L-proline and montmor

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Zamora-Ginez, Irma, Blanca Guadalupe Baez-Duarte, Eduardo Monjaraz, Guillermo Franco-Romero, Dan J. Peralta-Prado, and Abigail Briones-Montiel. "Aspartato aminotransferasa salival biomolécula diagnóstica de periodontitis como puente de interacción multidisciplinaria." Revista Biomédica 35, no. 2 (2024): 76–84. http://dx.doi.org/10.32776/revbiomed.v35i2.1186.

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Introducción: Es necesaria una adecuada interacción multidisciplinaria entre médicos y profesionales de la salud bucodental para disminuir las repercusiones de la enfermedad periodontal. Objetivo: Determinar si aspartato aminotransferasa salival (AST) es mejor biomolécula diagnóstica de periodontitis comparada con AST sérica e Interleucina- 6 (IL-6) y factor de necrosis tumoral-alfa (TNF-α) salivales y séricas. Material y Método: Estudio de metodología mixta, compuesta por dos subestudios, el primero, experimental, comparativo, transversal, retrospectivo para determinar la capacidad diagnóstic

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Miranda, Catarina S., Ana R. M. Ribeiro, Natália C. Homem, and Helena P. Felgueiras. "Spun Biotextiles in Tissue Engineering and Biomolecules Delivery Systems." Antibiotics 9, no. 4 (2020): 174. http://dx.doi.org/10.3390/antibiotics9040174.

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Nowadays, tissue engineering is described as an interdisciplinary field that combines engineering principles and life sciences to generate implantable devices to repair, restore and/or improve functions of injured tissues. Such devices are designed to induce the interaction and integration of tissue and cells within the implantable matrices and are manufactured to meet the appropriate physical, mechanical and physiological local demands. Biodegradable constructs based on polymeric fibers are desirable for tissue engineering due to their large surface area, interconnectivity, open pore structur

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Su, Li-Chen, Ying-Feng Chang, Chien Chou, et al. "Binding Kinetics of Biomolecule Interaction at Ultralow Concentrations Based on Gold Nanoparticle Enhancement." Analytical Chemistry 83, no. 9 (2011): 3290–96. http://dx.doi.org/10.1021/ac1028616.

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Rahdar, Abbas, Hamed Najafi-Ashtiani, and Esmael Sanchooli. "Fluorescence and dynamics studies of dye-biomolecule interaction in the nano-colloidal systems." Journal of Molecular Structure 1175 (January 2019): 821–27. http://dx.doi.org/10.1016/j.molstruc.2018.08.046.

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Dahiwade, Mandakini, Nikita Vyawahare, Prachi Garade, et al. "Biological activity and biomolecule interaction of pyridyl thiazole derivative and its copper complex." Journal of Molecular Liquids 404 (June 2024): 124936. http://dx.doi.org/10.1016/j.molliq.2024.124936.

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Dixit, Chitransh, Kanchan Lata Dixit, Chandra Kumar Dixit, Praveen Kumar Pandey, and Shavej Ali Siddiqui. "Analytical Techniques for Characterizing the Composition and Structure of Complex Biomolecules." International journal of Modern Achievement in Science, Engineering and Technology 2, no. 1 (2024): 36–41. https://doi.org/10.63053/ijset.57.

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The study explores analyzing complex biomolecules is essential for advancing our understanding of biological systems and their role in health and disease. This abstract provides an overview of analytical techniques used to characterize the composition and structure of these intricate biomolecules. One crucial technique is mass spectrometry, which enables the precise determination of a biomolecule's molecular weight and the identification of its constituent atoms and functional groups. Liquid chromatography-mass spectrometry (LC-MS) and tandem mass spectrometry (MS/MS) are commonly employed for

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Rudi, Ludmila, Liliana Cepoi, Tatiana Chiriac, and Svetlana Djur. "Interactions Between Potentially Toxic Nanoparticles (Cu, CuO, ZnO, and TiO2) and the Cyanobacterium Arthrospira platensis: Biological Adaptations to Xenobiotics." Nanomaterials 15, no. 1 (2024): 46. https://doi.org/10.3390/nano15010046.

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(1) Background: The widespread use of nanoparticles (NPs) implies their inevitable contact with living organisms, including aquatic microorganisms, making it essential to understand the effects and consequences of this interaction. Understanding the adaptive responses and biochemical changes in microalgae and cyanobacteria under NP-induced stress is essential for developing biotechnological strategies that optimize biomolecule production while minimizing potential toxicity. This study aimed to evaluate the interactions between various potentially toxic nanoparticles and the cyanobacterial stra

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Chen, Xuequan, Hannah Lindley-Hatcher, Rayko I. Stantchev, et al. "Terahertz (THz) biophotonics technology: Instrumentation, techniques, and biomedical applications." Chemical Physics Reviews 3, no. 1 (2022): 011311. http://dx.doi.org/10.1063/5.0068979.

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Terahertz (THz) technology has experienced rapid development in the past two decades. Growing numbers of interdisciplinary applications are emerging, including materials science, physics, communications, and security as well as biomedicine. THz biophotonics involves studies applying THz photonic technology in biomedicine, which has attracted attention due to the unique features of THz waves, such as the high sensitivity to water, resonance with biomolecules, favorable spatial resolution, capacity to probe the water–biomolecule interactions, and nonionizing photon energy. Despite the great pote

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Lamberti, Annalisa, Carmen Sanges, Nunzia Migliaccio, et al. "Silicon-Based Technology for Ligand-Receptor Molecular Identification." Journal of Atomic, Molecular, and Optical Physics 2012 (January 11, 2012): 1–5. http://dx.doi.org/10.1155/2012/948390.

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One of the most important goals in the fields of biology and medicine is the possibility to dispose of efficient tools for the characterization of the extraordinary complexity of ligand-receptor interactions. To approach this theme, we explored the use of crystalline silicon (cSi) technology for the realization of a biotechnological device in which the ligand-receptor interactions are revealed by means of optical measurements. Here, we describe a chemical procedure for the functionalization of microwell etched on silicon wafers, and the subsequent anchoring of biological molecules like an anti

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Kheirodin, Mohsen, Hossein Nejat Pishkenari, Ali Moosavi, and Ali Meghdari. "Study of Biomolecules Imaging Using Molecular Dynamics Simulations." Nano 10, no. 07 (2015): 1550096. http://dx.doi.org/10.1142/s1793292015500964.

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The process of imaging a biomolecule by atomic force microscope (AFM) is modeled using molecular dynamics (MD) simulations. Since the large normal force exerted by the tip on the biosample in contact and tapping modes may damage the sample structure and produce irreversible deformation, the noncontact mode of AFM (NC-AFM) is employed as the operating mode. The biosample is scanned using a carbon nanotube (CNT) as the AFM probe. CNTs because of their small diameter, high aspect ratio and high mechanical resistance attract many attentions for imaging purposes. The tip–sample interaction is simul

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Fang, Zhe, Shuaiwei Xu, Rui Cao, et al. "Interfacial Adsorption Mechanisms of Arginine, Glutamic Acid, Aspartic Acid, and Valine on Magnesium and Magnesium Alloy Surfaces: A First-Principles Investigation." Coatings 15, no. 5 (2025): 586. https://doi.org/10.3390/coatings15050586.

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Elucidating the interfacial interaction mechanisms between biomolecules and metal surfaces is crucial for designing functionalized biomedical materials. This study employs first-principles calculations based on density functional theory (DFT) to investigate the adsorption behaviors of arginine (Arg), glutamic acid (Glu), aspartic acid (Asp), and valine (Val) on magnesium (Mg) and Mg alloy surfaces. The adsorption behaviors of four kinds of amino acids on Mg and Mg alloy surfaces were analyzed through optimized adsorption configurations, adsorption energies (Eads), bond lengths, projected densi

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Savojardo, Castrense, Pier Luigi Martelli, and Rita Casadio. "Protein–Protein Interaction Methods and Protein Phase Separation." Annual Review of Biomedical Data Science 3, no. 1 (2020): 89–112. http://dx.doi.org/10.1146/annurev-biodatasci-011720-104428.

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In the last decade, newly developed experimental methods have made it possible to highlight that macromolecules in the cell milieu physically interact to support physiology. This has shifted the problem of protein–protein interaction from a microscopic, electron-density scale to a mesoscopic one. Further, nowadays there is increasing evidence that proteins in the nucleus and in the cytoplasm can aggregate in membraneless organelles for different physiological reasons. In this scenario, it is urgent to face the problem of biomolecule functional annotation with efficient computational methods, s

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Yuan, Yi, Congrong Chen, Xinyi Guo, Bing Li, Ni He, and Shaoyun Wang. "Noncovalent interactions between biomolecules facilitated their application in food emulsions' construction: A review." Comprehensive Reviews in Food Science and Food Safety 23, no. 1 (2023): 1–23. http://dx.doi.org/10.1111/1541-4337.13285.

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AbstractThe use of biomolecules, such as proteins, polysaccharides, saponins, and phospholipids, instead of synthetic emulsifiers in food emulsion creation has generated significant interest among food scientists due to their advantages of being nontoxic, harmless, edible, and biocompatible. However, using a single biomolecule may not always meet practical needs for food emulsion applications. Therefore, biomolecules often require modification to achieve ideal interfacial properties. Among them, noncovalent interactions between biomolecules represent a promising physical modification method to

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Giangregorio, Maria M., Giuseppe V. Bianco, Pio Capezzuto, Giovanni Bruno, and Maria Losurdo. "Surface plasmon resonance combined with spectroscopic ellipsometry read-out for probing surface–biomolecule interaction." Thin Solid Films 571 (November 2014): 478–83. http://dx.doi.org/10.1016/j.tsf.2013.11.143.

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