Academic literature on the topic 'Interactions between tissues'

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Journal articles on the topic "Interactions between tissues"

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Daniel, Władyslawa Anna, and Jacek Wöjcikowski. "Interactions between Promazine and Antidepressants at the Level of Cellular Distribution." Pharmacology & Toxicology 81, no. 6 (1997): 259–64. http://dx.doi.org/10.1111/j.1600-0773.1997.tb00003.x.

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AbstractThe pharmacokinetic interactions in clinical combinations of a phenolhiazine neuroleptic and antidepressants at the level of cellular distribution were investigated. Uptake experiments were performed on slices of various rat tissues as a system with intact lysosomes. Promazine and antidepressants (imipramine, amitriptyline, sertraline, fluoxetine) were incubated separately or jointly with tissue slices for 1 hr. Initial concentration of each drug was 5 uM. The interaction studies were carried out in the absence and presence of ammonium chloride (20 mM), a lysosomotropic compound which
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Kawao, Naoyuki, and Hiroshi Kaji. "Interactions Between Muscle Tissues and Bone Metabolism." Journal of Cellular Biochemistry 116, no. 5 (2015): 687–95. http://dx.doi.org/10.1002/jcb.25040.

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Tomas, Eva, Meghan Kelly, Xiaoqin Xiang, et al. "Metabolic and hormonal interactions between muscle and adipose tissue." Proceedings of the Nutrition Society 63, no. 2 (2004): 381–85. http://dx.doi.org/10.1079/pns2004356.

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From the perspective of a muscle physiologist, adipose tissue has long been perceived predominantly as a fuel reservoir that provides muscle and other tissues with NEFA when exogenous nutrients are insufficient for their energy needs. Recently, studies have established that adipose tissue is also an endocrine organ. Among the hormones it releases are adiponectin and leptin, both of which can activate AMP-activated protein kinase and increase fatty acid oxidation in skeletal muscle and probably other tissues. Deficiencies of leptin or leptin receptor, adiponectin and IL-6 are associated with ob
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Tsang, Anthony H., Johanna L. Barclay, and Henrik Oster. "Interactions between endocrine and circadian systems." Journal of Molecular Endocrinology 52, no. 1 (2013): R1—R16. http://dx.doi.org/10.1530/jme-13-0118.

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In most species, endogenous circadian clocks regulate 24-h rhythms of behavior and physiology. Clock disruption has been associated with decreased cognitive performance and increased propensity to develop obesity, diabetes, and cancer. Many hormonal factors show robust diurnal secretion rhythms, some of which are involved in mediating clock output from the brain to peripheral tissues. In this review, we describe the mechanisms of clock–hormone interaction in mammals, the contribution of different tissue oscillators to hormonal regulation, and how changes in circadian timing impinge on endocrin
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Nammour, S., H. S. Loh, R. De Moor, and C. P. Eduardo. "Interactions between Oral Tissues and External Light and Matters." International Journal of Dentistry 2012 (2012): 1. http://dx.doi.org/10.1155/2012/726259.

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Wang, Congcong, Zihan Yi, Ye Jiao, Zhong Shen, Fei Yang, and Shankuan Zhu. "Gut Microbiota and Adipose Tissue Microenvironment Interactions in Obesity." Metabolites 13, no. 7 (2023): 821. http://dx.doi.org/10.3390/metabo13070821.

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Obesity is an increasingly serious global health problem. Some studies have revealed that the gut microbiota and its metabolites make important contributions to the onset of obesity. The gut microbiota is a dynamic ecosystem composed of diverse microbial communities with key regulatory functions in host metabolism and energy balance. Disruption of the gut microbiota can result in obesity, a chronic metabolic condition characterized by the excessive accumulation of adipose tissue. Host tissues (e.g., adipose, intestinal epithelial, and muscle tissues) can modulate the gut microbiota via microen
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Rainbow, Roshni, Weiping Ren, and Li Zeng. "Inflammation and Joint Tissue Interactions in OA: Implications for Potential Therapeutic Approaches." Arthritis 2012 (June 18, 2012): 1–8. http://dx.doi.org/10.1155/2012/741582.

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It is increasingly recognized that the pathogenesis of cartilage degradation in osteoarthritis (OA) is multifactorial and involves the interactions between cartilage and its surrounding tissues. These interactions regulate proinflammatory cytokine-mediated cartilage destruction, contributing to OA progression as well as cartilage repair. This review explores the pathogenesis of OA in the context of the multiple tissue types in the joint and discusses the implications of such complex tissue interaction in the development of anti-inflammatory therapeutics for the treatment of OA.
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Nagase, T., T. Ito, M. Yanai, J. G. Martin, and M. S. Ludwig. "Responsiveness of and interactions between airways and tissue in guinea pigs during induced constriction." Journal of Applied Physiology 74, no. 6 (1993): 2848–54. http://dx.doi.org/10.1152/jappl.1993.74.6.2848.

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Mechanical interdependence between airways and tissues can modify the magnitude of induced bronchoconstriction. We questioned whether the guinea pig, an animal with abundant airway smooth muscle, would differ from other species in the relative responsiveness of and interactions between airways and tissues. Therefore we induced constriction with aerosolized methacholine (MCh) and partitioned responses into airway and tissue components. We measured tracheal and alveolar pressures using alveolar capsules in open-chest guinea pigs (n = 9) during mechanical ventilation [frequency = 1 Hz, tidal volu
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Elofsson, Hampus, Doroteya Raykova, and Agata Zieba Wicher. "Abstract 6772: Powerful background reduction in fluorescent tissue stains with an improved proximity-based technology for detection of protein-protein interactions." Cancer Research 83, no. 7_Supplement (2023): 6772. http://dx.doi.org/10.1158/1538-7445.am2023-6772.

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Abstract Immunofluorescent staining of tissues via in situ proximity ligation assay (isPLA) is now a well-established tool for highly sensitive detection of protein-protein interactions and their localization. It finds versatile applications in basic research, understanding of cellular processes, visualization of tissue architecture, and identification of biomarkers, among others. However, standard IF and isPLA techniques alike may suffer from high background. Tissues are particularly affected by background problems caused by autofluorescence and tissue infiltration of various cell types (e.g.
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Amponsah, N. T., E. E. Jones, H. J. Ridgway, and M. V. Jaspers. "Microscopy of some interactions between Botryosphaeriaceae species and grapevine tissues." Australasian Plant Pathology 41, no. 6 (2012): 665–73. http://dx.doi.org/10.1007/s13313-012-0159-x.

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Dissertations / Theses on the topic "Interactions between tissues"

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Dugan, Aisling Siobhan. "The interactions between BK virus and host cell receptors." View abstract/electronic edition; access limited to Brown University users, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3318311.

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Floyd, Hayley. "Cobalt, chromium implant wear : investigating interactions between products and the local environment and presenting an approach for mapping tissues." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8366/.

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Modern cobalt-chromium (CoCr) alloy compositions, for hip implants, were developed to resist the issues of wear and corrosion; however they still succumb to degradation. While the literature is vast, there is still a lack of understanding of the variability in implant-metal derivatives generated, and the effect such products can have on biological components other than just cells. In this thesis the effect of Co ions on type I collagen (main component of the extracellular matrix) was investigated. The conformation of the triple-helix was maintained, however the time taken for fibril formation
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Monnot, Pauline. "Rôle des interactions mécaniques entre tissus dans la mise en place du circuit olfactif du poisson-zèbre." Electronic Thesis or Diss., Sorbonne université, 2021. http://www.theses.fr/2021SORUS113.

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Alors que les signaux biochimiques impliqués dans la croissance axonale et la migration neuronale sont largement étudiés, la contribution des signaux mécaniques dans la formation des circuits neuronaux reste peu explorée in vivo. Nous cherchons à étudier comment les forces mécaniques contribuent à la formation du circuit olfactif du poisson-zèbre. Ce circuit se développe durant la morphogénèse de la placode olfactive (PO), par le mouvement passif des corps cellulaires qui s’éloignent de l’extrémité de leurs axones. Mes travaux de thèse s’intéressent à la contribution mécanique de l’œil, qui se
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Hollville, Enzo. "Impact du type de surface sur la réponse à l’exercice : du muscle au mouvement Interactions between fascicles and tendinous tissues in gastrocnemius medialis and vastus lateralis during drop landing How surface properties affect fascicle-tendon interactions during drop landing? Muscle-tendon interactions in jumping: influence of surface properties." Thesis, Sorbonne Paris Cité, 2019. http://www.theses.fr/2019USPCB018.

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Les propriétés des surfaces sportives peuvent impacter directement la performance et le risque de blessure en modulant la part d’énergie transmise à l'athlète lors de l'impact du pied sur la surface. Les pelouses naturelle et synthétique sont couramment utilisées sur les terrains de football et de rugby. Depuis quelques années, une nouvelle génération de pelouse dite naturelle renforcée a fait son apparition dans les clubs professionnels mais son influence sur la biomécanique du geste sportif est encore mal connue. Cette thèse vise à évaluer l'influence de trois types de surfaces (gazon nature
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Shapero, Kayle Sarah. "Interactions between valvular cells: implications for heart valve tissue engineering." Thesis, Boston University, 2013. https://hdl.handle.net/2144/11048.

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Thesis (Ph.D.)--Boston University<br>Approximately 1 in 1000 children are born with congenital cardiovascular defects yearly in the US, including many abnormalities in heart valves. Tissue engineered heart valves (TEHVs) offer a solution for replacement or repair of affected valves. However, its therapeutic application is limited, and in ovine models, no TEHV has performed satisfactorily in vivo for longer than twenty weeks, in part due to the absence of supporting data for selection of the appropriate cell type(s) to be incorporated into the construct. This partially owes to the lack of a ful
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Carlsson, Karin. "Tissue Factor in Complex : Studies of interactions between blood coagulation proteins." Doctoral thesis, Linköpings universitet, Biokemi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-63688.

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Many biological processes rely on specific protein-protein interactions, for example immune responses, cell signaling, transcription, and blood coagulation. Blood coagulation is initiated when a vessel wall is damaged, exposing tissue factor (TF) to the circulating factor VII/factor VIIa (FVII/FVIIa) which results in the formation of the TF:FVIIa complex and thereby the initiation of blood coagulation. One of the substrates for the TF:FVIIa complex is factor X (FX), which is activated to factor Xa (FXa), subsequently leading to a series of reactions resulting in clot formation. Tissue factor p
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Sim, Richard James. "Characterisation of the interaction between Neisseria meningitidis and the human host." Thesis, University of Birmingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246497.

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Neisseria meningitidis is an important cause of septicaemia and meningitis, yet can be found colonising the nasopharynx of up to 20% of healthy individuals. The aim of my work was to provide detailed characterisation of the cellular location of meningococcal carriage and subsequently select suitable models to investigate the molecular and cellular basis of the mechanisms by which the bacterium interacts with the human upper respiratory tract. This is the fundamental microbial-host interaction underlying the commensalism of Neisseria meningitidis. A survey of meningococcal carriage in tonsillar
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Qui, Lin. "Interaction between vascular endothelial cells and surface textured biomaterials." Thesis, Queen Mary, University of London, 2014. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8854.

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A promising approach to overcome thrombus and neointima formation on vascular grafts is to create a functional, quiescent monolayer of endothelial cells on the surface of implants. Surface topography of these implants is proven to enhance cell attachment and to reduce the inflammation associated with a smooth surface. Photoembossing is a relatively new, simple, environment-friendly and cost-effective technique to create surface topographies, since there is no etching step or mould needed. In this study, photopolymer films are photoembossed through contact mask photoembossing, while fibres are
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Aziz, Khalil Abdul. "Influence of GM-CSF and G-CSF on the mutual interactions between platelets and neutrophils." Thesis, University of Liverpool, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241473.

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Hockey, Verity Irena. "Characterising the molecular interaction between tissue factor pathway inhibitor and protein S." Thesis, Imperial College London, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.530472.

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Books on the topic "Interactions between tissues"

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Giuliani, Alessandra, and Alessia Cedola. Advanced High-Resolution Tomography in Regenerative Medicine: Three-Dimensional Exploration into the Interactions between Tissues, Cells, and Biomaterials. Springer, 2018.

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Jakob, Stephan M., and Jukka Takala. Oxygen transport in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0137.

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Adequate oxygen delivery is crucial for organ survival. The main determinants of oxygen delivery are cardiac output, haemoglobin concentration, and arterial oxygen saturation. The adequacy of oxygen delivery also depends on oxygen consumption, which may vary widely. Mixed venous oxygen saturation reflects the amount of oxygen not extracted by the tissues, and therefore provides useful information on the relationship between oxygen delivery and oxygen needs. If not in balance, tissue hypoxia may ensue and arterial lactate concentration increases. This occurs at higher oxygen delivery rates in a
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Radermacher, Peter, and Claus-Martin Muth. Pathophysiology and management of depth-related disorders. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0351.

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Decompression illness comprises decompression sickness resulting from tissue inert gas super-saturation and pulmonary barotraumas due to alveolar or airway over-distension. Gas bubbles can cause vascular obstruction or tissue compression, resulting in tissue ischaemia and oedema. Interactions between the blood–gas interface and the endothelium will result in further tissue damage, and trigger an inflammatory cascade with capillary leakage and haemoconcentration. Decompression illness may mimic any other emergency pathology and any emergency coinciding with decompression is ‘due to’ decompressi
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Dettman, Robert, Juan Antonio Guadix, Elena Cano, Rita Carmona, and Ramón Muñoz-Chápuli. The multiple functions of the proepicardial/epicardial cell lineage in heart development. Edited by José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, et al. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0020.

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The epicardium is the outer cell layer of the vertebrate heart. In recent years, both the embryonic and adult epicardium have revealed unsuspected peculiarities and functions, which are essential for cardiac development. In this chapter we review the current literature on the epicardium, and describe its evolutionary origin, the mechanisms leading to the induction of its extracardiac progenitor tissue, the proepicardium, and the way in which the proepicardium is transferred to the heart to form the epicardium. We also describe the epicardial epithelial–mesenchymal transition from which mesench
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Parlato, Marianna, and Jean-Marc Cavaillon. Innate immunity and the inflammatory cascade. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0299.

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Inflammation results from a complex interaction between a large number of mediators able to induce each other and to favour the generation of other inflammatory molecules (e.g. free radicals, lipid mediators, and proteases). The perpetuation of inflammation by these cascades of mediators is favoured by their ability to induce coagulation, leukocyte recruitment, and cell and tissue alteration (apoptosis, necrosis, and barrier disruption). Other cascades of mediators occur to generate anti-inflammatory mediators favouring the healing process. A neuroendocrine loop and neuromediators from central
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Vlachopoulos, Charalambos, and Nikolaos Ioakeimidis. Erectile dysfunction as a marker and predictor of cardiovascular disease. Edited by Charalambos Vlachopoulos. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0245.

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Erectile dysfunction (ED) is defined as the inability to obtain or maintain a penile erection to support satisfactory sexual performance. It is considered an early manifestation of generalized vascular disease and recognized as a marker of increased cardiovascular risk both acutely and chronically by predicting all-cause mortality, cardiovascular mortality, coronary events, stroke, and peripheral artery disease in men with and without known coronary artery disease. The link between ED and cardiovascular disease might reside in the interaction between androgen level, chronic inflammation, and c
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Chinoy, Hector, and Robert G. Cooper. Polymyositis and dermatomyositis. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0124.

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Polymyositis (PM), dermatomyositis (DM), and inclusion body myositis (IBM) form part of the idiopathic inflammatory myopathies (IIM), a heterogeneous group of rare autoimmune diseases characterized by an acquired proximal muscle weakness, raised muscle enzymes (including creatine kinase), inflammatory cell infiltrates in muscle biopsy tissue, electrophysiological abnormalities, and presence of circulating myositis-specific/myositis-associated autoantibodies. The underlying aetiology of IIM is poorly understood, but likely involves interactions between environmental and genetic risk factors. My
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Eleftheriou, Despina, and Paul A. Brogan. Paediatric vasculitis. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0136.

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Systemic vasculitis is characterized by blood vessel inflammation which may lead to tissue injury from vascular stenosis, occlusion, aneurysm, and/or rupture. Apart from relatively common vasculitides such as Henoch-Schönlein purpura (HSP) and Kawasaki's disease (KD), most of the primary vasculitic syndromes are rare in childhood, but are associated with significant morbidity and mortality. New classification criteria for childhood vasculitis have recently been proposed and validated. The cause of most vasculitides is unknown, although it is likely that a complex interaction between environmen
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Badimon, Lina, Felix C. Tanner, Giovanni G. Camici, and Gemma Vilahur. Pathophysiology of thrombosis. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198755777.003.0018.

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Ischaemic heart disease and stroke are major causes of death and morbidity worldwide. Coronary and cerebrovascular events are mainly a consequence of a sudden thrombotic occlusion of the vessel lumen. Arterial thrombosis usually develops on top of a disrupted atherosclerotic plaque because of the exposure of thrombogenic material, such as collagen fibrils and tissue factor (TF), to the flowing blood. TF, either expressed by subendothelial cells, macrophage- and/or vascular smooth muscle-derived foam-cells in atherosclerotic plaques, is a key element in the initiation of thrombosis due to its a
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Book chapters on the topic "Interactions between tissues"

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Hendry, I. A., C. E. Hill, and R. E. Bonyhady. "Interactions Between Developing Autonomic Neurons and their Target Tissues." In Ciba Foundation Symposium 83 - Development of the Autonomic Nervous System. John Wiley & Sons, Ltd., 2008. http://dx.doi.org/10.1002/9780470720653.ch10.

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Bertoluzza, A., P. Monti, R. Simoni, and R. Caramazza. "Interface Interactions Between Hydrophilic Contact Lenses and Ocular Tissues." In Interfaces in Medicine and Mechanics—2. Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-011-3852-9_44.

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Ferlin, Kimberly M., David S. Kaplan, and John P. Fisher. "Characterization of the Adhesive Interactions Between Cells and Biomaterials." In Micro and Nanotechnologies in Engineering Stem Cells and Tissues. John Wiley & Sons, Inc., 2013. http://dx.doi.org/10.1002/9781118574775.ch7.

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Roca, J., M. Hogan, and P. D. Wagner. "Interactions Between Convective and Diffusive Components of O2 Transport to the Tissues." In Update in Intensive Care and Emergency Medicine. Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-84209-2_26.

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Wiart, Joe, and Man Faï Wong. "Dosimetry of Interactions Between the Radioelectric Waves and Human Tissues - Hybrid Approach of the Metrology." In Measurements using Optic and RF Waves. John Wiley & Sons, Inc., 2013. http://dx.doi.org/10.1002/9781118586228.ch9.

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Edelstein-Keshet, Leah. "Pattern Formation Inside Living Cells." In SEMA SIMAI Springer Series. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-86236-7_5.

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AbstractWhile most of our tissues appear static, in fact, cell motion comprises an important facet of all life forms, whether in single or multicellular organisms. Amoeboid cells navigate their environment seeking nutrients, whereas collectively, streams of cells move past and through evolving tissue in the development of complex organisms. Cell motion is powered by dynamic changes in the structural proteins (actin) that make up the cytoskeleton, and regulated by a circuit of signaling proteins (GTPases) that control the cytoskeleton growth, disassembly, and active contraction. Interesting mat
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Pavard, Samuel, and C. Jessica E. Metcalf. "31. Trade-Offs between Mortality Components in Life History Evolution." In Human Evolutionary Demography. Open Book Publishers, 2024. http://dx.doi.org/10.11647/obp.0251.31.

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Little is known about the relative importance of different causes of death in driving the evolution of senescence and longevity across species. Here we argue that cause-specific mortality may be shaped by physiological trade-offs between mortality components, challenging the theoretical view that physiologically independent processes should senesce at the same rate, or that interactions between causes of death will make selection blind to the effects of specific causes of death. We review the evidence that risk of cancers trades off with risks of mortality from other diseases, and investigate
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Grote, J., G. Siegel, K. Zimmer, and A. Adler. "The Interaction Between Oxygen and Vascular Wall." In Oxygen Transport to Tissue XI. Springer US, 1989. http://dx.doi.org/10.1007/978-1-4684-5643-1_64.

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Majno, G. "Interactions Between Dead Cells and Living Tissue." In Novartis Foundation Symposia. John Wiley & Sons, Ltd., 2008. http://dx.doi.org/10.1002/9780470719336.ch5.

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Embery, G., R. J. Waddington, and K. S. Last. "The Interaction between Connective Tissues and Implant Materials." In Proceedings of the First International Conference on Interfaces in Medicine and Mechanics. Springer Netherlands, 1989. http://dx.doi.org/10.1007/978-94-011-7477-0_12.

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Conference papers on the topic "Interactions between tissues"

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Magni, Giada, Martina Banchelli, Leonardo Ciaccheri, et al. "In vitro analysis on the interaction between cell culture medium and blue LED light." In Optical Interactions with Tissue and Cells XXXVI, edited by Joel N. Bixler, Norbert Linz, and Alex J. Walsh. SPIE, 2025. https://doi.org/10.1117/12.3043442.

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Harunani, Maysoon, Mutian Shen, Zohar Nussinov, and Leonid Shmuylovich. "Establishing a causal link between the physiologic range of skin chromophore concentrations and physiologically relevant regions of CIELAB color space." In Optical Interactions with Tissue and Cells XXXVI, edited by Joel N. Bixler, Norbert Linz, and Alex J. Walsh. SPIE, 2025. https://doi.org/10.1117/12.3044143.

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Sun, Bingheng, Zhong Ren, and Gaoqiang Liang. "Finite element analysis and experiments on the interaction between pulsed laser and capillaries in skin tissue." In Seventh Optics Young Scientist Summit (OYSS 2024), edited by Yue Yang, Tian Jiang, Chao Zuo, et al. SPIE, 2025. https://doi.org/10.1117/12.3055809.

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Zhang, Lijuan, Spencer P. Lake, Victor K. Lai, Victor H. Barocas, and Mark S. Shephard. "Elucidation of Microstructural Interactions Between Collagen and Non-Fibrillar Matrix in Soft Tissue Using a Coupled Fiber-Matrix Model." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80401.

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The mechanical properties of soft connective tissues are governed by their collagen fiber network and surrounding non-fibrillar matrix (e.g., proteoglycans, cells, elastin, etc.). In order to understand how healthy tissues function, and how properties change in injury and disease, it is necessary to quantify the mechanical response of both the collagen network and the non-fibrillar matrix (NFM), as well as the nature of the interaction between these tissue constituents. Using collagen-agarose co-gels as a simple experimental tissue analog system, we have demonstrated how NFM contributes to the
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Frey, Christina R., Victor K. Lai, and Victor H. Barocas. "Structural and Mechanical Differences Between Pure Collagen and Fibrin Gels and Partially Digested Co-Gels." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53675.

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Natural and bio-engineered tissues are often composed of multiple fiber networks (fibrin, collagen, elastin, etc.). The microstructure and interactions between components determine the macroscopic mechanical properties of the tissues. Examples of multi-fiber networks include skin (collagen and elastin) and thrombus during the wound healing process (collagen and fibrin). In addition, tissue engineers (eg. [1]) use fibrin as a scaffold to seed cells for tissue growth; over time, networks of collagen and fibrin coexist as the fibrin is degraded and replaced with cell-synthesized collagen. Our gro
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Hyypio, Jeffrey D., Mohammad F. Hadi, Victor K. Lai, and Victor H. Barocas. "A Microscale Collagen-Fibrin Interacting Network Model With Comparison to Experimental Results." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80656.

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Many native and bioengineered soft tissues are composed of two or more types of biopolymer networks that mechanically define and support the material [1]. Modeling the response of multi-network soft tissues to mechanical loading can be difficult due to the heterogeneous nature of these materials and the large strains (&gt;1) involved. As tissues deform, the different biopolymer networks interact with one another and determine the overall stress-strain outcome for the tissue. Capturing this interaction could help improve the accuracy of a computer model to simulate the microscale behavior of so
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Zhao, Ronghua, and Alan G. Casson. "Abstract 1098: Interactions between P53 and IGF2 in human esophageal adenocarcinoma tissues and cell lines." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-1098.

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Al-Safadi, Samer, and Parsaoran Hutapea. "An Analytical Model for Predicting the Deflection of Hollow Surgical Needle in Soft Tissue." In ASME 2021 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/imece2021-71532.

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Abstract Considerable research efforts have been devoted for studying the interaction between surgical needles and soft tissues which can be used to evaluate the deflection of a bevel-tip needle inside a tissue. The development of an analytical model to predict the steering behavior of the needle during needle-tissue interactions could improve the performance of many percutaneous needle-based procedures. In this study, Euler-Bernoulli beam elastic foundation theory was utilized to model the needle as a cantilever beam moving along its longitudinal axis and undergoing various external loads. Th
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Lai, Victor K., Allan M. Kerandi, Spencer P. Lake, Robert T. Tranquillo, and Victor H. Barocas. "Collagen Network Architecture Varies Between Pure Collagen and Collagen-Fibrin Co-Gels." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80738.

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Naturally-occurring extracellular matrix (ECM) proteins, e.g. collagen I and fibrin, play an important role in tissues, conferring structural integrity and providing a biochemical environment for eliciting important cellular responses (e.g. migration). Tissue engineers use a variety of matrix polymers as initial scaffolds for seeding cells, sometimes in combination with one another (e.g. collagen-fibrin [1]). For example, our group fabricates arterial tissue equivalents (TEs) by seeding cells in a fibrin gel, which is gradually degraded over time and replaced by cell-produced collagen [2]. Whi
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Al-Safadi, Samer, and Parsaoran Hutapea. "Predicting Needle Deflection in Soft Tissue: a Computational Modeling Approach." In ASME 2023 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2023. http://dx.doi.org/10.1115/imece2023-113833.

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Abstract This study explores the mechanical interactions between surgical needles and soft tissues during procedures like biopsies and brachytherapy. A key challenge is needle tip deflection, which can cause deviation from the intended target. The study aims to develop an analytical model that predicts needle tip deflection during insertion by combining principles from interfacial mechanics and soft tissue deformation. A modified version of the dynamic Euler-Bernoulli beam theory is employed to model needle insertion and predict needle tip deflection. The model’s predictions are then compared
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Reports on the topic "Interactions between tissues"

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Funkenstein, Bruria, and Shaojun (Jim) Du. Interactions Between the GH-IGF axis and Myostatin in Regulating Muscle Growth in Sparus aurata. United States Department of Agriculture, 2009. http://dx.doi.org/10.32747/2009.7696530.bard.

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Growth rate of cultured fish from hatching to commercial size is a major factor in the success of aquaculture. The normal stimulus for muscle growth in growing fish is not well understood and understanding the regulation of muscle growth in fish is of particular importance for aquaculture. Fish meat constitutes mostly of skeletal muscles and provides high value proteins in most people's diet. Unlike mammals, fish continue to grow throughout their lives, although the size fish attain, as adults, is species specific. Evidence indicates that muscle growth is regulated positively and negatively by
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Rafaeli, Ada, Russell Jurenka, and Chris Sander. Molecular characterisation of PBAN-receptors: a basis for the development and screening of antagonists against Pheromone biosynthesis in moth pest species. United States Department of Agriculture, 2008. http://dx.doi.org/10.32747/2008.7695862.bard.

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The original objectives of the approved proposal included: (a) The determination of species- and tissue-specificity of the PBAN-R; (b) the elucidation of the role of juvenile hormone in gene regulation of the PBAN-R; (c) the identificationof the ligand binding domains in the PBAN-R and (d) the development of efficient screening assays in order to screen potential antagonists that will block the PBAN-R. Background to the topic: Moths constitute one of the major groups of pest insects in agriculture and their reproductive behavior is dependent on chemical communication. Sex-pheromone blends are
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Pilitkul, Trairak, Prapaporn Pisitkun, Asada Leelahavanichkul, and Poorichaya Somparn. Systems-investigation of aberrant signaling in immune cells of SLE mouse model. Faculty of Medicine, Chulalongkorn University, 2020. https://doi.org/10.58837/chula.res.2020.21.

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Autoimmune diseases occur when the immune cells react against self antigens and subsequently lead to inflammation in the tissues. The interactions between genetics and environmental triggers regulate the phenotypes and outcome of the diseases. Type I interferon has been shown as one of the most crucial cytokines involving in the pathogenesis of autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). SLE is a chronic systemic autoimmune disease which can result in autoantibody production and fatal glomerulonephritis. Activation via nucleic acid sensors can
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Pisitkun, Trairak, Prapaporn Pisitkun, Asada Leelahavanichkul, and Poorichaya Somparn. Systems biology investigation of immune cell regulation at the molecular level in SLE. Faculty of Medicine, Chulalongkorn University, 2018. https://doi.org/10.58837/chula.res.2018.24.

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Autoimmune diseases occur when the immune cells react against self-antigens and subsequently lead to inflammation in the tissues. The interactions between genetics and environmental triggers regulate the phenotypes and outcome of the diseases. Type I interferon has been shown as one of the most crucial cytokines involving in the pathogenesis of autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). SLE is a chronic systemic autoimmune disease which can result in autoantibody production and fatal glomerulonephritis. Activation via nucleic acid sensors can
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Pilitkul, Trairak, Prapaporn Pisitkun, and Asada Leelahavanichkul. Systems-investigation of aberrant signaling in immune cells of SLE mouse model. Faculty of Medicine, Chulalongkorn University, 2015. https://doi.org/10.58837/chula.res.2015.22.

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Autoimmune diseases occur when the immune cells react against self-antigens and subsequently lead to inflammation in the tissues. The interactions between genetics and environmental triggers regulate the phenotypes and outcome of the diseases. Type I interferon has been shown as one of the most crucial cytokines involving in the pathogenesis of autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). SLE is a chronic systemic autoimmune disease which can result in autoantibody production and fatal glomerulonephritis. Activation via nucleic acid sensors can
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Prusky, Dov, Lisa Vaillancourt, and Robert Fluhr. Host Ammonification by Postharvest Pathogens and its Contribution to Fungal Colonization and Symptom Development. United States Department of Agriculture, 2006. http://dx.doi.org/10.32747/2006.7592640.bard.

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Postharvest decay of fruits and vegetables caused by pathogenic and saprophytic fungi significantly impairs the quality and quantity of fresh produce brought to market. Consequently, there is considerable interest in identifying factors that determine the susceptibility of these commodities to pathogen infection. Insidious postharvest decays remain quiescent during fruit growth and harvest, but activate during the postharvest period. A key response to the physiological changes occurring during fruit ripening is the initiation of ammonium secretion by the pathogen. Ammonium ions at the infectio
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Funkenstein, Bruria, and Cunming Duan. GH-IGF Axis in Sparus aurata: Possible Applications to Genetic Selection. United States Department of Agriculture, 2000. http://dx.doi.org/10.32747/2000.7580665.bard.

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Many factors affect growth rate in fish: environmental, nutritional, genetics and endogenous (physiological) factors. Endogenous control of growth is very complex and many hormone systems are involved. Nevertheless, it is well accepted that growth hormone (GH) plays a major role in stimulating somatic growth. Although it is now clear that most, if not all, components of the GH-IGF axis exist in fish, we are still far from understanding how fish grow. In our project we used as the experimental system a marine fish, the gilthead sea bream (Sparus aurata), which inhabits lagoons along the Mediter
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Cherlet, Tracy C., and Leigh C. Murphy. Interaction Between Estrogen Receptor-Beta and the Transforming Growth Factor-Beta Signaling Cascade in Human Breast Tissue. Defense Technical Information Center, 2004. http://dx.doi.org/10.21236/ada430338.

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Matthews, Lisa, Guanming Wu, Robin Haw, et al. Illuminating Dark Proteins using Reactome Pathways. Reactome, 2022. http://dx.doi.org/10.3180/poster/20221027matthews.

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Diseases are often the consequence of proteins or protein complexes that are non-functional or that function improperly. An active area of research has focused on the identification of molecules that can interact with defective proteins and restore their function. While 22% percent of human proteins are estimated to be druggable, less than fifteen percent are targeted by FDA-approved drugs, and the vast majority of untargeted proteins are understudied or so-called "dark" proteins. Elucidation of the function of these dark proteins, particularly those in commonly drug-targeted protein families,
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Or, Etti, Tai-Ping Sun, Amnon Lichter, and Avichai Perl. Characterization and Manipulation of the Primary Components in Gibberellin Signaling in the Grape Berry. United States Department of Agriculture, 2010. http://dx.doi.org/10.32747/2010.7592649.bard.

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Seedless cultivars dominate the table grape industry. In these cultivars it is mandatory to apply gibberellin (GA) to stimulate berry development to a commercially acceptable size. These cultivars differ in their sensitivity to GA application, and it frequently results in adverse effects such as decreased bud fertility and increased fruit drop. Our long term goals are to (1) understand the molecular basis for the differential sensitivity and identify markers for selection of sensitive cultivars (2) to develop new strategies for targeted manipulation of the grape berry response to GA that will
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