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1

Rees, Louisa Elizabeth Natasha. "The regulation of interleukin-10." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322627.

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2

Schmid-Lossberg, Juliette. "Nachweis von Interleukin-1α, Interleukin-1ß, Interleukin-5 und Interleukin-10 im vaginalen Abstrich von gesunden Frauen". Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-114787.

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3

Powell, Mark Jason. "Gene regulation of murine interleukin -10." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299106.

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4

Crawley, Esther Madeleine. "Interleukin 10 in juvenile idiopathic arthritis." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249187.

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5

Forrester, Megan Amy. "Identification of interleukin-10 producing cells specific for Epstein-Barr virus latent membrane protein 1 and the involvement of interleukin-27 in their induction." Thesis, University of Aberdeen, 2011. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=167956.

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During latent Epstein-Barr virus (EBV) infection, the T helper cell response to the EBV latent membrane protein (LMP)1 is dominated by the production of IL-10, but by IFN- γ during acute EBV infection. The purpose of this thesis was to develop methods for the enumeration and characterisation of the IL-10 producing CD4+ T cells that respond to peptides of the EBV protein LMP1, and to investigate the possible involvement of IL-27 in the development of these cells. It was found that some human donors have very high concentrations of IL-27 within serum, which is not dependent on EBV infection stat
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6

Dohmen, Klaus Malte. "Die kritische Rolle von Interleukin-10 bei der Induktion nasaler Toleranz in der experimentellen Autoimmun-Myokarditis (EAM)." [S.l. : s.n.], 2007. http://nbn-resolving.de/urn:nbn:de:bsz:289-vts-58242.

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7

Walter, Claudia. "Bestimmung der Zytokine Interleukin-1ra, Interleukin-6, Interleukin-10 und Interleukin-12 im Vaginalsekret bei Frauen mit Bakterieller Vaginose." Diss., lmu, 2004. http://nbn-resolving.de/urn:nbn:de:bvb:19-28461.

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8

Capper, Emma Rachel. "The human interleukin-10 and interleukin-10 receptor system : molecular & genetic analysis of SLE and recurrent miscarriage." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424695.

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9

Clarke, Christopher Jeremy Paul. "Molecular mechanisms of the anti-inflammatory cytokines interleukin-4 and interleukin-10." Thesis, Imperial College London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285172.

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10

Rempel, Julia D. "Interleukin-12 and interleukin-10 regulation of antibody responses upon protein antigen immunization." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ41623.pdf.

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11

Müller, Riccarda [Verfasser]. "Effekte einer Interleukin-10 Überexpression in humanen Gelenkchondrozyten und Interaktion von Interleukin-10 mit Tumor Nekrose Faktor-α / Riccarda Müller". Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2009. http://d-nb.info/1027813623/34.

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12

Schardt, Victor. "Vergleichende Untersuchungen zur Hefepilzbesiedelung von Mundhöhle und Vagina und Bestimmung von Interleukin-4, Interleukin-10 und Interleukin-12." Diss., lmu, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-155152.

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13

Leppert, Kyle McDonald McMurray Robert G. "The effect of glycogen depletion on responses of interleukin-1beta, interleukin-6, and interleukin-10 to maximal exercise." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2009. http://dc.lib.unc.edu/u?/etd,2599.

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Thesis (M.A.)--University of North Carolina at Chapel Hill, 2009.<br>Title from electronic title page (viewed Oct. 5, 2009). "... in partial fulfillment of the requirement for the degree of Master of Arts in the Department of Exercise and Sport Science Exercise Physiology." Discipline: Exercise and Sports Science; Department/School: Exercise and Sport Science.
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14

Strong, Victoria. "Modulation of dendritic cell function by interleukin-10." Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393790.

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15

Clutton, Genevieve Tyndale. "HIV-specific interleukin-10 responses and immune modulation." Thesis, University of Oxford, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.589623.

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Interleukin-l0 (IL-10) helps to limit the duration of potentially harmful inflammatory responses but has also been implicated in the persistence of a number of chronic viral infections. This thesis aimed to investigate the phenotype and function of mv -specific IL-l0-producing cells in chronic HIV-I infection, and the effect of IL-10 blockade on responses to candidate HIV -I vaccines. A cytokine capture assay was used to determine the HIV -specific cellular sources of IL- 10 in PBMC from 55 chronically infected individuals. A rare subset of CD8+ T cells was found to be the major HIV -I Gag-spe
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16

OBAFEMI, TOLULOPE FESAYO. "THE EFFECTS OF INTERLEUKIN 6 AND INTERLEUKIN 10 ON FRAILTY IN C57BL/6 MICE." Thesis, The University of Arizona, 2016. http://hdl.handle.net/10150/613394.

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Studies have shown that pro-inflammatory IL-6 and anti-inflammatory IL-10 interleukins may correlate to frailty and aging. This frailty can be defined in the context of clinical symptoms which include sarcopenia and osteoporosis, decreased activity level; or in the context of increased susceptibility to adverse health outcomes from a deficient immune system. In this experiment we tested a cohort of conditionally regulated IL-6 and IL-10 mice with controls (IL-6tg+.rtTA(r/r) (n=8), IL-10(-/-). IL-10tg+ rtTA(r/r) (n=10) and rtTA(r/r) (n=5)) under frailty assessments and immunological cell analys
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17

Unterberger, Claudia. "Molekulare Mechanismen der Induktion von Interleukin-10 durch Glukokortikoide." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-74135.

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18

Karimi, Sepideh. "Expression of interleukin-10 in vitro and in vivo." Thesis, University of Ottawa (Canada), 1994. http://hdl.handle.net/10393/6527.

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Classification of cytokines into T helper type 1 (Th1) and T helper type 2 (Th2) has helped in the elucidation of the mechanisms of resistance or susceptibility to infections. HIV infection causes CD4$\sp+$ T cell dysfunction and depletion by indirect mechanisms; for example: inhibition of immunoregulatory cytokines. Interleukin (IL-10), the subject of this study, is secreted mostly by CD4$\sp+$ human Th2-like, but also by Th0,Th1-like, and by a proportion of CD8$\sp+$ T cell clones. HIV sero-positive patients exhibit depressed cell mediated immune responses, B cell hyperplasia, and hypergamma
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19

Chang, Wen-Lan William. "Genetic and functional dissection of rhesus cytomegalovirus interleukin-10 /." Connect to Digital dissertations. Restricted to UC campuses. Access is free to UC campus dissertations, 2002. http://uclibs.org/PID/11984.

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20

Azbil, Tatiana. "Nachweis von Candida-Spezies und Bestimmung der Zytokine Interleukin-1 beta, Interleukin-1ra, Interleukin-4, Interleukin-6, Interleukin-8, Interleukin-10 und Interleukin-12 im Vaginalsekret und im Serum bei Schwangeren in Relation zum Gestationsalter." Diss., lmu, 2006. http://nbn-resolving.de/urn:nbn:de:bvb:19-57576.

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21

Cavendish, Victoria Jane. "The regulation of tumour necrosis factor-alpha and interleukin-10 by interleukin-13 in monocytic cells." Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.392976.

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22

Dokka, Sujatha. "IL-10 gene therapy for the treatment of pulmonary inflammation." Morgantown, W. Va. : [West Virginia University Libraries], 2000. http://etd.wvu.edu/templates/showETD.cfm?recnum=1421.

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Thesis (Ph. D.)--West Virginia University, 2000.<br>Title from document title page. Document formatted into pages; contains ix, 132 p. : ill. (some col.) Vita. Includes abstract. Includes bibliographical references.
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23

Kampshoff, Jörg. "Die Wirkung der Interleukine 4, 10 und 13 auf die Koinkubation von Endothelzellen und mononukleären Zellen, gemessen an der Freisetzung von PDGF, Interleukin-1-[beta] [Interleukin-1-beta] und Interleukin-6." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972057684.

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24

VanDeusen, Jeffrey Bryan. "A role for stat-1 in regulating interleukin 10 production following LPS challenge." Connect to this title online, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1084860074.

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Thesis (Ph. D.)--Ohio State University, 2005.<br>Title from first page of PDF file. Document formatted into pages; contains ix, 64 p.; also includes graphics (some col.). Includes bibliographical references (p. 54-64). Available online via OhioLINK's ETD Center.
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25

Dockstader, Kristy. "Role of interleukin-10 in lung repair during influenza infection." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/59050.

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The mammalian lung is intricately designed for effective gas exchange. However, infections such as influenza can damage the lung tissue and can cause a critical decrease in lung performance. Influenza is a single stranded RNA virus from the Orthomyxoviridae family. Seasonal influenza outbreaks cause up to 600 deaths in Canada each year, with increased death tolls during years with pandemic strains. Influenza A virus primarily infects the epithelial cells of the respiratory system and leads to acute respiratory infections. Tissue destruction occurs both as a result of viral-mediated apoptoti
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26

Le, Moine Olivier. "Interleukin-10 in liver ischaemia-reperfusion injury and alcoholic cirrhosis." Doctoral thesis, Universite Libre de Bruxelles, 1996. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/212296.

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27

Williams, Lynn Michelle. "A comparison of interleukin-10 and lipopolysaccharide signalling in monocytes." Thesis, Imperial College London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264968.

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28

Chong, Wai-po, and 莊偉波. "Association of interleukin 10 promoter polymorphisms with systemic lupus erythematosus." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B29295981.

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29

Thompson, Kerry C. "The expression and function of interleukin-10 in liver injury." Thesis, University of Southampton, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285873.

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30

Madan, Rajat. "Novel insights into the in vivo biology of Interleukin-10." University of Cincinnati / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1242133534.

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31

Wendland, Sylke [Verfasser]. "Interleukin-6-, Interleukin-10- und TNF-alpha-Plasmaspiegel bei Patienten mit transplantations-assoziierter lymphoproliferativer Erkrankung / Sylke Wendland." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2013. http://d-nb.info/1035406365/34.

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32

Asselineau, Delphine. "Le polymorphisme du promoteur de l'interleukine-10 et son rôle éventuel dans la maladie d'Alzheimer." Thesis, Paris 6, 2014. http://www.theses.fr/2014PA066089.

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La maladie d'Alzheimer (MA) est une maladie neurodégénérative irréversible et progressive entraînant des troubles cognitifs et comportementaux. L'inflammation est caractéristique de la MA. L'interleukine-10 (IL-10), une cytokine anti-inflammatoire a été associée à un risque plus faible de développer la MA. Cependant le lien entre l'IL-10 et la progression de la MA n'a jamais été étudié. Le but de cette thèse a été d'étudier le rôle de l'IL-10 dans le développement ainsi que dans la progression de la MA. Pour mener à bien cette étude, 31 sujets atteints par la MA et 20 sujets contrôles cognitiv
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33

Ramos, Rodrigo Nalio. "The immunosuppressive microenvironment in cancer : local and systemic effects on patients' monocytes." Thesis, Lyon 1, 2015. http://www.theses.fr/2015LYO10270.

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Chez les patients atteints de cancer, les cellules néoplasiques échappent au contrôle du système immunitaire en raison de leur faible immunogénicité et d'une capacité exacerbée à moduler le micro-environnement. Nous décrivons ici les effets de ce micro-environnement tumoral sur la différenciation locale et systémique des monocytes et l'impact de la présence de Macrophages-Associés aux Tumeurs (TAM) CD163+ sur la survie des patientes atteintes de cancer du sein. Par une analyse de cytométrie en flux, nous décrivons un composition hétérogène des sous-types de TAM CD163low et CD163high, où nous a
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34

Frisch, Kristina. "Klonierung von IL-10 und IL-10-Homologen und Funktionsanalyse in einem Mausmodell der polymikrobiellen Sepsis." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=973392185.

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35

Schwarz, Annika. "Einfluss von Interleukin-10 auf die Differenzierung von Monozyten zu Dendritischen Zellen." Doctoral thesis, Universitätsbibliothek Leipzig, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-148424.

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Interleukin-10 ist ein Paradebeispiel eines immunhemmenden Zytokins. Es konnte nachgewiesen werden, dass eine Reihe von Tumoren Interleukin-10 produziert, um einer Antitumor-Immunantwort zu entgehen. Viele Studien haben sich mit dem Einfluss von Interleukin-10 auf die antigenpräsentierenden Fähigkeiten der Dendritischen Zellen beschäftigt. Es gibt eindeutige Hinweise, dass der Effekt von tumorproduziertem Interleukin-10 nicht nur in einer hemmenden Wirkung auf die Ausreifung Dendritischer Zellen besteht, sondern dass Interleukin-10 zu einer Reduktion der Anzahl an Dendritischen Zellen führen
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36

Wang, Allen Ping-Lun. "The effect of hypoxia on the production of interleukin-10 (IL-10) in human mononuclear cells." Thesis, University of Leicester, 2010. http://hdl.handle.net/2381/10228.

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Macrophages play an important role in both innate and adaptive immunity by engulfing intruding pathogens and damaged or infected cells, antigen presentation, and by secretion of immune mediators. Interleukin 10 (IL-10) is a potent anti-inflammatory cytokine mainly produced by macrophages in response to cell activation, which serves to suppress immune reactions and inflammation. Hypoxia refers to oxygen deprivation. It is a common condition found in pathological tissues. The relationship between hypoxia and the production of IL-10 by macrophage is not yet thoroughly understood. In previous unpu
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37

Aydın, Gönül Karaaslan Tamer. "Deneysel omurilik yaralanmasında İnterlökin-10'un İnterlökin 1-Beta ve İnterlökin-6 üzerine etkilerinin incelenmesi /." Isparta : SDÜ Tıp Fakültesi, 2007. http://tez.sdu.edu.tr/Tezler/TT00331.pdf.

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38

Frellstedt, Linda. "Induction and characterization of endotoxin tolerance in equine peripheral blood mononuclear cells in vitro." Thesis, Virginia Tech, 2010. http://hdl.handle.net/10919/44307.

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Endotoxemia is responsible for severe illness in horses. Individuals can become unresponsive to the endotoxin molecule after an initial exposure; this phenomenon has been called developing a state of â endotoxin toleranceâ (ET). ET has been induced in horses in vivo; however, cytokine expression associated with ET has not been investigated. The purpose of this study was to develop and validate a method for inducing ET in equine peripheral blood mononuclear cells (PBMCs) in vitro, and to describe the cytokine profile which is associated with the ET. <p> Blood was collected from 6 healthy hor
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39

Gehrcke, Jan-Philip. "Investigation of the interleukin-10-GAG interaction using molecular simulation methods." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-163205.

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Glycosaminoglycans (GAGs) are linear polysaccharides, built of periodically occurring disaccharide units. GAGs are ubiquitous in the extracellular matrix (ECM), where they exhibit multifarious biological activities. This diversity arises from - among others - their ability to interact with and regulate a large number of proteins, such as cytokines, chemokines, and growth factors. As of the huge variety in their chemical configuration, GAGs are further sub-classified into different types (heparin, for instance, is one of these sub-classes). Hence, GAGs are a diverse class of molecules, which su
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40

Schardt, Victor [Verfasser], and Ernst Rainer [Akademischer Betreuer] Weissenbacher. "Vergleichende Untersuchungen zur Hefepilzbesiedelung von Mundhöhle und Vagina und Bestimmung von Interleukin-4, Interleukin-10 und Interleukin-12 / Victor Schardt. Betreuer: Ernst Rainer Weissenbacher." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2013. http://d-nb.info/1032862645/34.

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41

Künze, Georg. "Untersuchungen zur Wechselwirkung von Interleukin-10 mit Glykosaminoglykanen mittels NMR-Spektroskopie." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-176115.

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Das Zytokin Interleukin-10 (IL-10) ist ein Schlüsselspieler in der Regulation des Immunsystems mit pro- und anti-inflammatorischen Funktionen. Es spielt eine wichtige Rolle bei der Terminierung und Unterdrückung einer Entzündungsantwort, die ansonsten zu einer bleibenden Schädigung des Gewebes führen kann. Eine Dysregulation von IL-10 ist mit verschiedenen Krankheitsbildern wie chronischen Entzündungen, Autoimmunerkrankungen und Krebs assoziiert. IL-10 wird von einem breiten Spektrum von Zelltypen, darunter hauptsächlich hämatopoetische Zellen, aber auch epitheliale und mesenchymale Zellen, geb
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42

Etling, Michele R. "THE AGING MUCOSAL IMMUNE SYSTEM IN THE INTERLEUKIN-10-DEFICIENT MOUSE." Case Western Reserve University School of Graduate Studies / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=case1184295867.

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43

Wong, Justine Karoline. "HIV-1 Tat-induced interleukin-10 from monocytes is subtype specific." Diss., [La Jolla] : University of California, San Diego, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p1465088.

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Thesis (Ph. D.)--University of California, San Diego, 2009.<br>Title from first page of PDF file (viewed June 22, 2009). Available via ProQuest Digital Dissertations. Includes bibliographical references (p. 27-35).
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44

Taubert, Christina Maria. "Molecular mechanisms underlying the regulation of interleukin-10 production in macrophages." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/10034083/.

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Interleukin (IL)-10 is an immunosuppressive cytokine that plays a crucial role in preventing inflammatory and autoimmune pathology. The dysregulation of IL-10 during infection can lead to either an over-exuberant response damaging the host, or conversely ineffective pathogen clearance. Macrophages are important players in inflammatory responses and produce IL-10 in response to Toll-like receptor (TLR) ligation along with protective pro-inflammatory cytokines. The collective regulation of these cytokines is central to the generation of an effective but balanced immune response. We observed that
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45

Blalock, Emily L. "Roles of TH2 and TH17 CD4+ T-Helper Cell Cytokines in the Pathogenesis of Experiemental Cytomegalovirus Retinitis." Digital Archive @ GSU, 2012. http://digitalarchive.gsu.edu/biology_diss/122.

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Human cytomegalovirus (HCMV) is a betaherpesvirus that infects up to 80% of the population worldwide, and establishes latency in monocytes and bone marrow cells. Reactivated HCMV can become an opportunistic pathogen in individuals who are immunocompromised, such as those with acquired immunodeficiency syndrome (AIDS). HCMV infection of AIDS patients causes a sight-threatening retinitis that leads to vision loss and blindness in up to 46% of this population without antiretroviral treatment. Because untreated HIV-infected individuals exhibit the loss of cell-mediated immunity and alterations in
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46

Costa, Ana Carolina Vieira da. "Avaliação da produção de interleucina 6, fator de necrose tumoral e interleucina 10 em hemoculturas de pacientes com Leishmaniose Cutânea localizada." Universidade Federal de Goiás, 2017. http://repositorio.bc.ufg.br/tede/handle/tede/7243.

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Submitted by JÚLIO HEBER SILVA (julioheber@yahoo.com.br) on 2017-05-02T18:25:08Z No. of bitstreams: 2 Dissertação - Ana Carolina Vieira da Costa - 2017.pdf: 14344522 bytes, checksum: b31bb0d6ea37eec29c70d7d93855498f (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2017-05-03T11:56:23Z (GMT) No. of bitstreams: 2 Dissertação - Ana Carolina Vieira da Costa - 2017.pdf: 14344522 bytes, checksum: b31bb0d6ea37eec29c70d7d93855498f (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8
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Vendruscolo, Cynthia do Prado. "Avaliação dos efeitos inflamatório e oxidante do ozônio medicinal em articulações sinoviais de equinos hígidos." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/10/10136/tde-25052017-133250/.

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A ozonioterapia consiste na aplicação de ozônio medicinal, uma mistura de ozônio e oxigênio, que através das espécies reativas de oxigênio e produtos de lipoperoxidação exercem diversos efeitos no organismo como, melhora da oxigenação e metabolismo dos tecidos, angiogênese, aumento dos mecanismos antioxidantes, melhora do sistema imune, efeito anti-inflamatório, entre outros. Esta modalidade terapêutica já é amplamente estudada na medicina humana e vem sendo aplicada na medicina esportiva equina no tratamento de osteoartrite, porém sem estudos expressivos que comprovem sua segurança e eficácia
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48

Ruiz-Gómez, Gloria, John C. Hawkins, Jenny Philipp, et al. "Rational Structure-Based Rescaffolding Approach to De Novo Design of Interleukin 10 (IL-10) Receptor-1 Mimetics." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-215877.

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Tackling protein interfaces with small molecules capable of modulating protein-protein interactions remains a challenge in structure-based ligand design. Particularly arduous are cases in which the epitopes involved in molecular recognition have a non-structured and discontinuous nature. Here, the basic strategy of translating continuous binding epitopes into mimetic scaffolds cannot be applied, and other innovative approaches are therefore required. We present a structure-based rational approach involving the use of a regular expression syntax inspired in the well established PROSITE to defin
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49

Ruiz-Gómez, Gloria, John C. Hawkins, Jenny Philipp, et al. "Rational Structure-Based Rescaffolding Approach to De Novo Design of Interleukin 10 (IL-10) Receptor-1 Mimetics." Public Library of Science, 2016. https://tud.qucosa.de/id/qucosa%3A30052.

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Tackling protein interfaces with small molecules capable of modulating protein-protein interactions remains a challenge in structure-based ligand design. Particularly arduous are cases in which the epitopes involved in molecular recognition have a non-structured and discontinuous nature. Here, the basic strategy of translating continuous binding epitopes into mimetic scaffolds cannot be applied, and other innovative approaches are therefore required. We present a structure-based rational approach involving the use of a regular expression syntax inspired in the well established PROSITE to defin
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50

Howes, A. F. "The regulation of interleukin-10 and interleukin-12 in macrophages : investigating the differential regulation of IL-10 and IL-12 in C57BL/6 and BALB/c mice." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1409974/.

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Abstract:
Pattern recognition receptors (PRR) detect microbial products and induce cytokines which shape the immunological response. Interleukin-12 (IL-12) is a proinflammatory cytokine important for the differentiation of T helper 1 (Th1) cells which produce IFN-γ to activate macrophages and eradicate intracellular pathogens. In contrast, interleukin-10 (IL-10) is an immunosuppressive cytokine that minimises immune-driven host pathology, but can also lead to defective pathogen clearance. The regulation of IL-10 and IL-12 is therefore of interest due to their central roles in the orchestration of an eff
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