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Dissertations / Theses on the topic 'Intestinal mucosal immune system'

Author: Grafiati

Published: 4 June 2021

Last updated: 12 February 2022

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1

Thompson, Fiona Marie. "Activation of the mucosal immune system and growth of the small intestine at weaning /." Title page, abstract and contents only, 1994. http://web4.library.adelaide.edu.au/theses/09PH/09pht4677.pdf.

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2

Stange, Jörg. "Studies on host-pathogen interactions at mucosal barrier surfaces using the murine intestinal parasite Eimeria falciformis." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2013. http://dx.doi.org/10.18452/16716.

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Wir nutzten in dieser Studie den apikomplexen Parasiten Eimeria falciformis als Modell. Unsere Ergebnisse zeigen, dass das in infizierten Wildtypmäusen dominierende Zytokin IFN-γ für Immunschutz und für die Entwicklung der Darmpathologie entbehrlich war. E. falciformis-infizierte IFN-γR-/- and IFN-γ-/- Mäuse zeigten extremen Körpergewichtsverlust und starke Pathologie im Darm. Die Entwicklung des Parasiten in diesen Mäusen war überraschenderweise reduziert. Diese Beobachtungen gingen mit einer drastisch erhöhten Produktion von parasiten-spezifischem IL-17A und IL-22 durch CD4+ T Zellen einher.

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3

Tyrer, Peter Charles, and n/a. "Targeting M-cells for oral vaccine delivery." University of Canberra. Health Sciences, 2004. http://erl.canberra.edu.au./public/adt-AUC20060427.122012.

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An in vitro model of the follicle-associated epithelia that overlie the Peyer's patches of the small intestine was developed and validated to examine the mechanisms of mucosal antigen sampling. This model displays many phenotypic and physiological characteristics of M cells including apical expression of [alpha]5[beta]l integrin and enhanced energy dependent participate transport. CD4+ T-cells were shown to be an important influence on the development of Mlike cells. The model was used to examine the M cell mediated uptake of several putative whole-cell killed bacterial vaccines. Greater numbe

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4

Munro, Grant Hamilton. "Murine giardiasis : intestinal mucosal immune responses." Thesis, University of Edinburgh, 1985. http://hdl.handle.net/1842/20043.

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5

Hu, Hong-Zhen. "Purinergic neurogenic intestinal mucosal secretion." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1100028634.

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Thesis (Ph. D.)--Ohio State University, 2004.<br>Document formatted into pages; contains 171 p. Includes bibliographical references. Abstract available online via OhioLINK's ETD Center; full text release delayed at author's request until 2005 Nov. 10.

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6

Santos, Liliane Martins dos. "Breakdown of intestinal homeostasis by mucosal infections triggers adaptive immune responses against antigens from commensal bacteria." Universidade Federal de Minas Gerais, 2011. http://hdl.handle.net/1843/BUOS-8XUR5V.

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The gastrointestinal tract of mammals is inhabited by thousands of distinct species of commensal microorganisms that exist in a mutualistic relationship with the host. It has previously been shown that these gut microbes play an important role in modulating host immune responses. On the other hand, commensals can also contribute to pathology in the context of acute infection. For instance, oral infections with Toxoplasma gondii in certain inbred strains of mice lead to an exacerbated intestinal inflammation that is accompanied by a loss of diversity within the gut flora. Furthermore, the micro

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7

Morris, Bruce C. "Intestinal Mucosal Mast Cell Immune Response and Pathogenesis of Two Eimeria Acervulina Isolates in Broiler Chickens." Thesis, Virginia Tech, 2002. http://hdl.handle.net/10919/36228.

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Five experiments were conducted comparing differential intestinal immune responses to two isolates of Eimeria acervulina (EA), EA1 and EA2. In three experiments, broiler chicks were divided into control (non-challenged), EA1, or EA2 challenged (14 days of age) groups. On day 6 post-challenge (PC), changes in body weight were determined, intestinal lesions were scored, and duodenal tissue was evaluated for morphometric alterations and mucosal mast cell responses. EA1 produced duodenal lesions and reduced villus height to crypt depth ratios when compared to controls; however, no differences we

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8

Etling, Michele R. "THE AGING MUCOSAL IMMUNE SYSTEM IN THE INTERLEUKIN-10-DEFICIENT MOUSE." Case Western Reserve University School of Graduate Studies / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=case1184295867.

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9

Blazek, Alisa D. "A Simulated Altitude Device can Improve Endurance Performance without Mucosal Immune System Compromise." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1267567607.

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10

Pardo, Camacho Cristina. "Intestinal mucosal humoral response and neuro-immune interaction as contributors to the pathophysiology of diarrhea-predominant Irritable Bowel Syndrome." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/670719.

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La Síndrome de l’Intestí Irritable (SII) és un trastorn gastrointestinal crònic i prevalent que cursa amb alteracions a la motilitat intestinal i amb dolor abdominal. La SII constitueix un trastorn recurrent i potencialment incapacitant sense un marcador de diagnòstic específic i únicament hi ha disponibles tractaments pal·liatius. L’absència d’una patofisiologia ben establerta destaca la necessitat d’identificar les causes orgàniques subjacents a les alteracions intestinal i la generació de símptomes. A la mucosa intestinals d’aquests pacients s’ha identificat un cert grau d’inflamació així

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11

Ewing, Patricia A., and n/a. "Developmental profiles of mucosal immunity in pre-school children." University of Canberra. Human & Biomedical Sciences, 2000. http://erl.canberra.edu.au./public/adt-AUC20060707.154930.

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Previous studies of the ontogeny of the mucosal immune system have shown a significant increase in salivary Immunoglobulin A levels occurring at about five years of age. This study has monitored a group of 3 and 4 year old children during one year of attendance at Pre-School to examine whether such an increase could be linked to increased antigenic exposure associated with moving into a school like environment. Saliva samples were collected at regular intervals and analysed for immunoglobulin and total protein levels. Daily health records were maintained for each child, and a detailed social a

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12

Christoforidou, Zoe. "The role of gut microbiota in driving the development of the mucosal immune system." Thesis, University of Bristol, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.689676.

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It is now accepted that gut microbiota are crucial for the development of the mucosal immune system. It has been suggested that differences in early life microbial colonisation may be associated with variable predisposition to allergic, auto immune, and inflammatory diseases. The exact underlying mechanisms are difficult to study in human infants, however, the similarities in physiology and nutritional requirements between pigs and humans suggest that piglets can be good models to elucidate the pathways involved. The aim of this PhD project was to investigate how differences in microbiota, ear

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13

Ucan, Uckun Sait. "T cells and cytokines in the lamina propria of the pig." Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389234.

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14

Harris, Cecilia. "Effect of environmental factors on the development of the mucosal immune system in the piglet." Thesis, University of Bristol, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419675.

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15

Armstrong, Fiona. "Interactions between sources of resistant starch, intestinal cancer and the immune system." Thesis, University of Newcastle Upon Tyne, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340689.

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16

Sansom, Nigel P. "Antigen sampling by porcine intestinal Peyer's patch M-cells." Thesis, University of Aberdeen, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322637.

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17

Sjöblom, Markus. "The duodenal mucosal bicarbonate secretion : role of melatonin in neurohumoral control and cellular signaling /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. {[distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3521.

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18

Harvey, Joanna E. "T cell and macrophage differentiation markers in the normal and inflamed human intestine." Thesis, University of Southampton, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236511.

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19

Nyakundi, Jane Nyamoita. "A study of intestinal pathology and its significance in Trypanosoma brucei brucei infection." Thesis, University of Salford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366023.

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20

Law, Yuet Ching. "Specific Compartmentalization of IgA ASCs in Mouse Salivary Glands via Differential Expression of Chemokines and Chemokine Receptors." BYU ScholarsArchive, 2008. https://scholarsarchive.byu.edu/etd/1952.

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The mucosal system, which forms a barrier between internal organ systems and the external environment, is frequently exposed to pathogenic microorganisms. Immunoglobulin A (IgA) antibody secreting cells (ASCs) localize in the lamina propria, and produce IgA antibodies which help protect mucosal tissues. The concept of a common mucosal immune system in which IgA ASCs have the ability to populate any mucosal site has been proposed (1, 2). However, recent research has suggested that IgA ASCs primed in different mucosal sites might possess different sets of chemokine receptors, and therefore migra

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21

Powell, Nicholas. "Defining the role of the transcription factor T-bet in the innate immune system in intestinal inflammation." Thesis, King's College London (University of London), 2014. https://kclpure.kcl.ac.uk/portal/en/theses/defining-the-role-of-the-transcription-factor-tbet-in-the-innate-immune-system-in-intestinal-inflammation(d78ff348-ac4f-4ef6-b1a9-7e527226bf04).html.

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Mice lacking the transcription factor T-bet in the innate immune system (Tbx21-/- x Rag2-/- Ulcerative Colitis, or TRUC) develop microbiota-dependent inflammatory bowel disease (IBD). The innate immune mechanisms responsible for causing disease are still to be resolved, yet potentially offer novel insights into the pathogenesis of IBD, and how T-bet might influence inflammation in the gut. In this thesis it was shown that chronic IBD in TRUC mice was dependent on interleukin-17A (IL-17A) producing IL-7R+ CD90+ innate lymphoid cells (ILCs). Depletion of ILCs or IL-17A neutralization cured disea

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22

Zhang, Min Fen. "The role of milk transforming growth factor-[beta](TGF-[beta]) in the development of the infant gut and gut mucosal immune system." Title page, contents and abstract only, 2000. http://web4.library.adelaide.edu.au/theses/09PH/09phz51.pdf.

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In title, [beta] is represented by the Greek letter. Copies of author's previously published articles inserted. Errata pages pasted onto back end-paper. Bibliography: leaves 104-137. Studies milk TGF-[beta] and its receptors in the post-natal gut using a rat model to investigate a link between milk TGF-[beta] and the development of the infant gut and gut mucosal immune system. Finds maternal milk may be a major source of TGF-[beta] to the immature gut and may react with receptors on the cells of the mucosal immune system along the gastro-intestinal tract, modulating infant mucosal immune respo

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23

Da, Silva Polyana. "A novel image analysis approach to characterise the effects of dietary components on intestinal morphology and immune system in Atlantic salmon." Thesis, University of Stirling, 2013. http://hdl.handle.net/1893/20055.

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The intestinal tract of salmonids provides a dynamic interface that not only mediates nutrient uptake but also functions as the first line of defence against ingested pathogens. Exposure of the immune system to beneficial microorganisms and different dietary immunostimulants via the intestine has been shown to prime the immune system and help in the development of immune competence. Furthermore, the morphology and function of teleostean intestines are known to respond to feed components and to ingested and resident bacterial communities. Histological appraisal is still generally considered to

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24

Javed, Najma H. "Interaction of the immune system and enteric nervous system in guinea pig distal colon : mediators causing release of acetylcholine and chloride secretion during intestinal anaphylaxis /." The Ohio State University, 1992. http://rave.ohiolink.edu/etdc/view?acc_num=osu148777866328618.

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25

Stoicov, Calin. "Pathogenesis of the Helicobacter Induced Mucosal Disease: A Dissertation." eScholarship@UMMS, 2010. https://escholarship.umassmed.edu/gsbs_diss/477.

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Helicobacter pylori causes chronic gastritis, peptic ulceration and gastric cancer. This bacterium is one of the most prevalent in the world, but affects mostly the populations with a lower socioeconomical status. While it causes gastric and duodenal ulcers in only 20% of infected patients, less then 1% will develop gastric adenocarcinoma. In fact, H. pylori is the most important risk factor in developing gastric cancer. Epidemiological studies have shown that 80% of gastric cancer patients are H. pylori positive. The outcome of the infection with this bacterium depends on bacterial factors, d

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26

Steimle, Alexander [Verfasser], and Julia-Stefanie [Akademischer Betreuer] Frick. "How intestinal commensals affect the immune system and the outcome of inflammatory disorders : novel molecular insights / Alexander Steimle ; Betreuer: Julia-Stefanie Frick." Tübingen : Universitätsbibliothek Tübingen, 2017. http://d-nb.info/1199545643/34.

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27

Todd, Derrick James. "Role of the Intestinal Immune System in the Pathogenesis of Autoimmune Diabetes in the BB Rat Model of Type 1 Diabetes Mellitus." eScholarship@UMMS, 2001. https://escholarship.umassmed.edu/gsbs_diss/138.

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The intestine is the largest lymphoid organ in the body, challenged constantly by an enonnous quantity and diversity of antigens. Distinct from peripheral lymphocytes, intestinal lymphocytes have evolved unique mechanisms of tolerance and appear to govern mucosal processes such as "chronic physiologic inflammation" and oral tolerance. Failure of mucosal tolerance has been implicated in the pathogenesis of several diseases, including inflammatory bowel disease, celiac disease, and even autoimmune diabetes. One population of intestinal lymphocytes, intraepithelial lymphocytes (IELs), exists with

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28

Unger, Benjamin Landry. "The role of growth factors and Rho kinase (ROCK) in the regulation of IL-1 mediated pro-inflammatory cytokine production in intestinal epithelial cells." Diss., Online access via UMI:, 2009.

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29

Heyer, Charlotte Maria Elisabeth [Verfasser], and Volker [Akademischer Betreuer] Stefanski. "Impact of dietary phosphorus and fermentable substrates on the immune system and the intestinal microbiota of the pig / Charlotte Maria Elisabeth Heyer ; Betreuer: Volker Stefanski." Hohenheim : Kommunikations-, Informations- und Medienzentrum der Universität Hohenheim, 2016. http://d-nb.info/1122458231/34.

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30

Heyer, Charlotte [Verfasser], and Volker [Akademischer Betreuer] Stefanski. "Impact of dietary phosphorus and fermentable substrates on the immune system and the intestinal microbiota of the pig / Charlotte Maria Elisabeth Heyer ; Betreuer: Volker Stefanski." Hohenheim : Kommunikations-, Informations- und Medienzentrum der Universität Hohenheim, 2016. http://d-nb.info/1122458231/34.

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31

Vitoretti, Luana Beatriz. "Estudo de mecanismos reguladores da inflamação pulmonar tardia após isquemia e reperfusão intestinal em ratos." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/42/42136/tde-20022015-140750/.

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Citocinas geradas durante a I/R-i promovem lesão pulmonar aguda e podem causar imunossupressão. Investigamos se a inflamação pulmonar após dias de reperfusão intestinal está relacionada com alterações no sistema imune. Ratos machos Wistar foram submetidos a oclusão da artéria mesentérica superior por 45 min e a 2 h, 3, 5 ou 20 dias de reperfusão. Observamos que após 5 dias de reperfusão intestinal enterobactérias estão presentes nos linfonodos mesentéricos e que os neutrófilos circulantes estão mais ativos no combate a patógenos, enquanto leucócitos da cavidade peritoneal não. Notamos aumento

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32

Estruch, Cucarella Guillem. "ASSESSMENT OF THE LONG-TERM IMPACT OF HIGH PLANT PROTEIN DIETS ON THE INTESTINAL STATUS OF THE ON-GROWING GILTHEAD SEA BREAM (Sparus aurata, L.)." Doctoral thesis, Universitat Politècnica de València, 2018. http://hdl.handle.net/10251/113063.

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Aunque el uso de altos niveles de fuentes de proteína vegetal en piensos para doradas de engorde se ha alcanzado con éxito en cuanto al crecimiento, estas dietas todavía están asociadas a efectos negativos en la eficiencia nutricional y en la capacidad inmunitaria. El intestino es el órgano donde se produce la primera interacción entre el pez, los nutrientes y las bacterias del medio, y desarrolla un papel crucial en la digestión de los nutrientes y la respuesta infamatoria e inmune. Esta tesis doctoral se centra en el impacto de distintas dietas con altos niveles de proteína vegetal, y especi

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33

Massot, Cladera Malen. "Efecte dels components bioactius del cacau sobre la microbiota i el sistema immunitari intestinal de rata." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/361098.

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En els últims anys ha crescut considerablement l’interès per descobrir aliments naturals funcionals amb propietats beneficioses per a l’hoste. En aquest sentit, el cacau ha passat a ser un dels principals subjectes d’estudi pel seu contingut en flavonoides. Són molts els estudis que associen la ingesta de cacau amb efectes beneficiosos sobre la salut. A més, se li han atribuït propietats immunomoduladores en rata. En base a aquests efectes descrits, l’objectiu d’aquesta Tesi Doctoral va ser establir l’efecte de dietes enriquides amb cacau, flavonoides del cacau i fibra de cacau sobre la mic

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34

Gómez, Gallego Carlos. "Funcionalidad de las poliaminas sobre el desarrollo del sistema inmune y la microbiota intestinal durante el periodo de lactancia : influencia del procesado de las fórmulas infantiles en el contenido en poliaminas y en la liberación de péptidos durante la digestión: ensayo de funcionalidad empleando como modelo ratones BALB/cOlaHsd lactantes= Polyamine functionality on immune system development and intestinal microbiota during lactation : influence of the infant formula manufacturing on polyamine content and bioactive peptide releasing during digestion: assay of functionality in a lactating BALB/cOlaHsd mice model." Doctoral thesis, Universidad de Murcia, 2014. http://hdl.handle.net/10803/284822.

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Tesis por compendio de publicaciones<br>Introducción: La lactancia materna es la forma de alimentación recomendada, siempre que sea posible, al menos durante los primeros seis meses de vida. Si esto no es posible, existen fórmulas artificiales con las que poder cubrir los requerimientos nutricionales de los recién nacidos. La exposición a determinados factores ambientales, incluidos factores nutricionales, durante el periodo intrauterino y los meses posteriores al nacimiento podría determinar la susceptibilidad a determinadas enfermedades en etapas posteriores de la vida. Se ha demostrado una

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35

Ho, Shu-Ying, and 何淑螢. "The Effect of Mushroom Polysaccharides on Intestinal Mucosal Immune System." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/17428955621835487187.

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碩士<br>國立臺灣大學<br>漁業科學研究所<br>101<br>Mushroom polysaccharides are distinguished as important immunostimulant in animal body. Administrate glucan to animal inducing different isotype immunoglobulin secretion. Immunoglobulin A is the major antibody in the intestinal mucus, and transcytosis of IgA across epithelia is mediated by the poly-Ig receptor. Neutralization is important protection mechanism against antigen by IgA in gut. In the present study simulate acting intestinal mucosal immune system. Further to study the effects of mushroom polysaccharide on immunoglobulin A (IgA), immunoglobulin G (I

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36

Gannon, Mark. "Immunomodulatory effects of dietary fibre supplementation: effects on cytokine and antibody production and lymphocyte population profiles." Thesis, 2009. http://hdl.handle.net/10155/37.

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Gastrointestinal microflora has been shown to have a bi-directional relationship with the host immune system. A variety of fermentable carbohydrate polymers largely pass through the small intestine, providing fermentable substrates for gut microflora. Dietary fibre supplementation may provide a strategy for manipulating the intestinal bacterial profile, changing the interaction with the mucosal immune system, thereby modulating the host immune system. We used a BBc rat animal model to evaluate the effects of oat bran and wheat bran dietary fibre on the immune system. Previous collaborative eff

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37

Cummins, Adrian Gerard. "Interaction of the mucosal immune system with the epithelium of the small intestine / Adrian Gerard Cummins." 1989. http://hdl.handle.net/2440/18824.

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38

Chege, Duncan Mwithiga. "Evaluating the Interaction of HIV and the Immune System in Mucosal Tissues." Thesis, 2013. http://hdl.handle.net/1807/35172.

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90% of Human Immunodeficiency Virus (HIV) infections are acquired across the genital or gastrointestinal mucosa, and infection leads to profound depletion of CD4+ lymphocytes. Antiretroviral therapy can restore blood CD4+ T cells. However, immune dysfunction and defects in mucosal antimicrobial defence persist. Some CD4+ T-subsets, particularly antimicrobial Th17 cells, show enhanced susceptibility to HIV infection and are also preferentially depleted in the course of HIV infection; the latter may allow microbial translocation into the bloodstream. Genital infections have been shown to have di

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39

Yi-Shin, Pan, and 潘宜欣''. "The effect of Ling-zhi polysaccharides on intestinal immune system." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/62921427271235207770.

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碩士<br>國立陽明大學<br>微生物暨免疫學研究所<br>89<br>Oral tolerance is the obstacle for inducing immunity by oral route. There were some powerful mucosal adjuvants, such as CT and LT that had been studied for their capacity in immune potentiation. Due to their toxicity per se, their usage was carefully considered. In the previous study from our laboratory, it was shown that Ling-zhi polysaccharides isolated from Ganoderma lucidum had the effects on anti-tumor and modulating the immune system through oral administration, though their absorption by intestine and metabolism were unclear. This implied that Ling-zh

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VENKATARAMANA, SHRIRAM. "Paradoxical effects of immune cells on the enteric nervous system in intestinal inflammation." Thesis, 2009. http://hdl.handle.net/1974/5340.

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Inflammatory bowel disease causes structural and functional alterations in the enteric nervous system (ENS). Since the onset of intestinal inflammation involves the activation of resident immune cells as well as rapid influx of infiltrating cells, we proposed that changes in the ENS are a result of the release of toxic inflammatory factors. We hypothesized that early damage to the ENS in inflammation is caused by harmful levels of nitric oxide (NO) generated by the enzyme inducible nitric oxide synthase (iNOS) found in immune cells. This was assessed in the 2, 4, 6-trinitrobenzene sulfonic aci

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Wu, Kuan-Long, and 吳冠龍. "Oral efficacy and intestinal mucosal immune responses induced by the complex of DNA encoding Green Fluorescent Protein disulfide-crosslinked low molecular linear polyetheleneimine, and sodium hyaluronate." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/53270759868027462758.

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碩士<br>中原大學<br>生物科技研究所<br>103<br>A gene delivery system carrying the gene segment of the antigen protein into the host body to express in non-viral way to stimulate mucosal and systemic immune responses has been developed. The current study used the ternary complex（DNA-CLPEI-HA）composed of plasmid DNA, disulfide-crosslinked low molecular linear polyetheleneimine(CLPEI) ,and hyaluronic acid (HA), which exhibited high gene transfection efficiency and low toxicity in cell culture systems. The examination by electron microscopes showed the physical properties of DNA-CLPEI-HA complex. The stability

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Cortiçada, Patrícia Gonçalves Moreira de Abreu. "Medicamentos Biológicos e Doença Inflamatória Intestinal." Master's thesis, 2015. http://hdl.handle.net/10451/26789.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2014<br>A doença de Crohn e a Colite Ulcerosa são duas doenças que, genericamente, se designam por doenças inflamatórias do intestino. Estas são doenças crónicas que se caracterizam por períodos de inflamação (com exacerbação dos sintomas), seguidos por períodos de remissão. As lesões podem ser limitadas à região do reto e do colon (colite ulcerosa) ou estenderem-se por todo o trato digestivo (doença de Crohn), podendo essas lesões serem relativamente simples ou mais complexas, levando

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Lu, Hsueh-Yun, and 呂學耘. "Study on the effect of wild bitter melon on regulatory T cells and further modulation of intestinal immune system." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/10648809373817639453.

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博士<br>國立臺灣大學<br>生化科技學系<br>104<br>Chronic inflammation and immune disorder are associated with insulin resistance, allergy, inflammatory bowel disease, etc. Regulatory T lymphocytes (Treg) suppress a variety of inflammatory and pathological immune responses. Wild bitter melon (WBM) has been demonstrated to improve the insulin resistance, but its effect on immune is still unclear. Therefore, the aim of this study is to investigate the effect of WBM on the intestinal immune system and Treg development. First, to investigate the improvement in insulin resistance of wild bitter melon is involved wi

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44

Worbs, Tim [Verfasser]. "Chemokine receptor CCR7 contributes to intranodal T-cell motility and functional organization of the intestinal immune system / by Tim Worbs." 2007. http://d-nb.info/985045809/34.

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Constâncio, Inês Margarida Gomes. "Relatórios de Estágio e Monografia intitulada “Probióticos como estimulantes do Sistema Imunitário."." Master's thesis, 2020. http://hdl.handle.net/10316/93075.

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Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de Farmácia<br>No âmbito da Unidade Curricular "Estágio Curricular" do Mestrado Integrado em Ciências Farmacêuticas, foi redigido o seguinte documento, que engloba os relatórios dos estágios referentes a Farmácia Comunitária e a Indústria Farmacêutica. Em cada um deles, é feita e descrita uma análise SWOT, analisando pontos internos - Forças (S) e Fraquezas (W) - e pontos externos - Oportunidades (O) e Ameças (T). Atualmente, os probióticos são definidos pela Food and Agriculture Organization e pela Wo

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Fundová, Petra. "Slizniční imunita v nemocech horního respiračního traktu a autoimunitních onemocnění." Doctoral thesis, 2016. http://www.nusl.cz/ntk/nusl-353440.

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Mucosal immune system comprises not only the major compartment of the immune system but also important interface with the outer environment. It is responsible in maintaining an intricate balance with the danger and non-danger stimuli of the outer world by employing specific anatomical features and unique functional mechanisms. Mucosal immune system has been long understudied, perhaps due to the limited accessibility, and its biological importance is thus still underevaluated. However, it has become evident that it is important to study mucosal immune system not only in local mucosal affections

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Santos, Nuno Ricardo Silva. "Da hipótese da higiene à hipótese do microbioma." Master's thesis, 2019. http://hdl.handle.net/10284/8720.

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A hipótese da Higiene originalmente proposta por Strachan em 1989 é caraterizada pela associação do tamanho das famílias e o seu status social com a prevalência de doenças tais como a febre dos fenos e eczemas em crianças. Segundo a sua hipótese, o motivo pelo qual, atualmente, existem mais alergias e/ou doenças autoimunes deve-se a uma menor exposição aos patogénios enquanto criança. Mais tarde esta hipótese foi modificada por Rook, que afirmava que eram os microorganismos presentes na microflora comensal, se alterados, enquanto crianças, que podiam modular, intensificar ou inibir os mecanism

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