Academic literature on the topic 'Intracellular uptake'

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Journal articles on the topic "Intracellular uptake"

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Yanagawa, N., and O. D. Jo. "Intracellular acidification inhibits opposum kidney cell phosphate uptake." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 272, no. 6 (1997): R1904—R1911. http://dx.doi.org/10.1152/ajpregu.1997.272.6.r1904.

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The aim of our study is to examine the effect of intracellular pH (pHi) on inorganic phosphate (Pi) uptake by a proximal tubular cell line, the opposum kidney (OK) cells. The OK cell pHi (7.48 +/- 0.02; n = 12) was altered to levels between 6.5 and 8.5 by the high-K+ nigericin method, and cell uptakes were measured at 7.5 extracellular pH. It was found that pHi acidification suppressed Pi uptake with a decrease in maximal reaction rate, whereas alkalinization had no significant effect. Other Na(+)-dependent transport systems for glucose and amino acid were not affected by these pHi changes. Th
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Gesbert, Gael, Elodie Ramond, Fabiola Tros, et al. "Importance of Branched-Chain Amino Acid Utilization in Francisella Intracellular Adaptation." Infection and Immunity 83, no. 1 (2014): 173–83. http://dx.doi.org/10.1128/iai.02579-14.

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Intracellular bacterial pathogens have adapted their metabolism to optimally utilize the nutrients available in infected host cells. We recently reported the identification of an asparagine transporter required specifically for cytosolic multiplication ofFrancisella. In the present work, we characterized a new member of the major super family (MSF) of transporters, involved in isoleucine uptake. We show that this transporter (here designated IleP) plays a critical role in intracellular metabolic adaptation ofFrancisella. Inactivation of IleP severely impaired intracellularF. tularensissubsp.no
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Choi, Moon-Jeong, R. Pierson, Yongmin Chang, Haiquing Guo, and Inn-Kyu Kang. "Enhanced Intracellular Uptake of CdTe Quantum Dots by Conjugation of Oligopeptides." Journal of Nanomaterials 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/291020.

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Arg-Gly-Asp-Ser (RGDS), a typical membrane-permeable carrier peptide, was conjugated with mercaptoisobutyric acid-immobilized CdTe quantum dot (CTNPs) to enhance the intracellular uptake of quantum dots. Mean size of mercaptoisobutyric acid-immobilized quantum dots (37 nm) as determined by dynamic light scattering was increased up to 54 nm after RGDS immobilization. It was found, fromin vitrocell culture experiment, that fibroblast (NIH 3T3) cells were well proliferated in the presence of RGDS-conjugated quantum dots (RCTNPs), and the intracellular uptake of CTNPs and RCTNPs was studied by mea
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Yoon, Sorah, and John J. Rossi. "Aptamers: Uptake mechanisms and intracellular applications." Advanced Drug Delivery Reviews 134 (September 2018): 22–35. http://dx.doi.org/10.1016/j.addr.2018.07.003.

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Korchak, Helen M., Barbara E. Corkey, Gordon C. Yaney та Laurie E. Kilpatrick. "Negative regulation of ligand-initiated Ca2+uptake by PKC-βII in differentiated HL60 cells". American Journal of Physiology-Cell Physiology 281, № 2 (2001): C514—C523. http://dx.doi.org/10.1152/ajpcell.2001.281.2.c514.

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In phagocytic cells, fMet-Leu-Phe triggers phosphoinositide remodeling, activation of protein kinase C (PKC), release of intracellular Ca2+ and uptake of extracellular Ca2+. Uptake of extracellular Ca2+ can be triggered by store-operated Ca2+channels (SOCC) and via a receptor-operated nonselective cation channel(s). In neutrophilic HL60 cells, the PKC activator phorbol myristate acetate (PMA) activates multiple PKC isotypes, PKC-α, PKC-β, and PKC-δ, and inhibits ligand-initiated mobilization of intracellular Ca2+ and uptake of extracellular Ca2+. Therefore PKC is a negative regulator at severa
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Wang, X., M. Ji, J. F. Wang, Z. Liu, and Z. Y. Yang. "Anaerobic uptake of phosphate in an anaerobic–aerobic granular sludge sequencing batch reactor." Water Science and Technology 53, no. 9 (2006): 63–70. http://dx.doi.org/10.2166/wst.2006.266.

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An unusual phenomenon of anaerobic phosphate uptake under alternating anaerobic/aerobic condition was observed in a granular sludge sequencing batch reactor, fed with acetate as sole organic substrate. Anaerobic phosphate uptake efficiencies remained at 50–70% as the influent P/COD was increased from 2/100 to 4/100, and results showed that anaerobic uptake of phosphate was correlated with anaerobic absorption of acetate. Excluding the main possibility of chemical phosphate removal, it appeared that phosphate uptake during the anaerobic phase was associated with organisms enriched in the reacto
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Das, Santanu, Stuart Horowitz, Carolyn G. Robbins, Marwan Eid El-Sabban, Namita Sahgal, and Jonathan M. Davis. "Intracellular uptake of recombinant superoxide dismutase after intratracheal administration." American Journal of Physiology-Lung Cellular and Molecular Physiology 274, no. 5 (1998): L673—L677. http://dx.doi.org/10.1152/ajplung.1998.274.5.l673.

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We have previously demonstrated that recombinant human copper-zinc superoxide dismutase (rhCu,ZnSOD) is rapidly incorporated into cells of airways, respiratory bronchioles, and alveoli after intratracheal administration. The present study examines whether this cellular uptake is specific for rhCu,ZnSOD or whether other proteins are similarly incorporated into lung cells. Twenty-two newborn piglets (2–3 days old, 1.2–2.0 kg) were intubated and mechanically ventilated. Eight piglets received fluorescently labeled recombinant human manganese superoxide dismutase (rhMnSOD), six received fluorescen
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Suvannapura, A., and N. R. Levens. "Norepinephrine uptake by rat jejunum: modulation by angiotensin II." American Journal of Physiology-Gastrointestinal and Liver Physiology 254, no. 2 (1988): G135—G141. http://dx.doi.org/10.1152/ajpgi.1988.254.2.g135.

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Angiotensin II (ANG II) is believed to stimulate sodium and water absorption from the small intestine by enhancing sympathetic nerve transmission. This study is designed to determine whether ANG II can enhance sympathetic neurotransmission within the small intestine by inhibiting norepinephrine (NE) uptake. Intracellular NE accumulation by rat jejunum was concentration dependent and resolved into high- and low-affinity components. The high-affinity component (uptake 1) exhibited a Michaelis constant (Km) of 1.72 microM and a maximum velocity (Vmax) of 1.19 nmol.g-1.10 min-1. The low-affinity c
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Juliano, R. L., and K. Carver. "Cellular uptake and intracellular trafficking of oligonucleotides." Advanced Drug Delivery Reviews 87 (June 2015): 35–45. http://dx.doi.org/10.1016/j.addr.2015.04.005.

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Zhang, Yong, and Ning Huang. "Intracellular uptake of CdSe-ZnS/polystyrene nanobeads." Journal of Biomedical Materials Research Part B: Applied Biomaterials 76B, no. 1 (2005): 161–68. http://dx.doi.org/10.1002/jbm.b.30347.

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Dissertations / Theses on the topic "Intracellular uptake"

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Nativo, Paola. "Uptake and Intracellular Fate of Surface-Modified Gold Nanoparticles." Thesis, University of Liverpool, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.507707.

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Hassuna, Noha. "The role of tetraspanins in the uptake of intracellular pathogens." Thesis, University of Sheffield, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522414.

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LETTIERO, BARBARA. "Uptake and intracellular trafficking of nanoparticles for potential medical use." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2011. http://hdl.handle.net/10281/20247.

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My PhD project has been focused on the characterization of the in vitro behavior of engineered Nanoparticles (NPs), especially concerning the first phases of interaction with barriers of different nature present in the body : a model of air-blood barrier , e.g. alveolar epithelial A30 cell line and an immunological barrier represented by the activation of the complement system. In light of these considerations, I have first compared the mechanism of cellular uptake and intracellular distribution of Solid Lipid NPs and Iron Oxide NPs over time. Then, I have studied the likely molecular basis of
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Tünnemann, Gisela. "Toxicity, uptake and applications of intracellular delivery by cell penetrating peptides." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-105432.

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Schütz, Irene [Verfasser]. "Uptake and intracellular delivery of nanoparticles into mammalian cells / Irene Schütz." Berlin : Freie Universität Berlin, 2016. http://d-nb.info/1104170698/34.

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Wei, Hai. "Analysis and intracellular uptake of ß-cyclodextrin and a ß-cyclodextrin complex." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0010/MQ60194.pdf.

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Chindera, Kantaraja. "Cell uptake properties of Polyhexamethylene Biguanide (PHMB) and applications in intracellular delivery." Thesis, Royal Veterinary College (University of London), 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.618319.

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Jindi, Elias Sonav. "Evaluation of mechanisms for accessing intracellular targets for protein-based drugs." Thesis, Uppsala universitet, Avdelningen för farmaceutisk biokemi, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-445320.

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Over the years, biological drugs have evolved and have made breakthroughs in diseases associated with extracellular proteins. However, intracellular proteins that cause disease progression are still largely inaccessible. Examples of diseases that are caused by an intracellular aggregation of proteins are neurodegenerative diseases such as Parkinson's disease, Huntington's disease (HD), and Alzheimer's disease (AD). The purpose of the work is to find a strategy to reach the neurons intracellularly. The goal is to be able to design a biological drug that enters the neuron by investigating differ
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Pelc, Radek. "Calcium mobilisation and uptake in smooth muscle cells : role of intracellular calcium stores." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275402.

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Clark, S. A. "The mechanism of uptake and intracellular fate of leupeptin in rat yolk sacs." Thesis, Keele University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376309.

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Books on the topic "Intracellular uptake"

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Brooks, Andrew William. Uptake, accumulation and intracellular distribution of aluminium and iron in the terrestrial snail, Helix Aspersa. University of Manchester, 1993.

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Afghan, Sophia G. Monoclonal antibodies for the diagnosis of tuberculosis and the study of properties of some of the mycobacterial antigens especially in relation to macrophages uptake of BCG and intracellular survival and killing. University of Birmingham, 1994.

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Rapid hyaluronan uptake is associated with enhanced motility and transformation: Implications for an intracellular mode of action. National Library of Canada, 1999.

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Book chapters on the topic "Intracellular uptake"

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Andersen, Helene, Ladan Parhamifar, and S. Moein Moghimi. "Uptake and Intracellular Trafficking of Nanocarriers." In Intracellular Delivery II. Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-017-8896-0_6.

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Fielding, Christopher J., Anita Bist, and Phoebe E. Fielding. "Selective Uptake of Lipoprotein Free Cholesterol and Its Intracellular Transport — Role of Caveolin." In Intracellular Cholesterol Trafficking. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5113-3_17.

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Blomhoff, Rune, Kaare R. Norum, and Trond Berg. "Inter- and Intracellular Transport of Retinol in the Liver." In Receptor-Mediated Uptake in the Liver. Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-70956-2_34.

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Hopkins, Colin R. "Uptake and Intracellular Processing of Cell Surface Receptors." In New Insights into Cell and Membrane Transport Processes. Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-5062-0_18.

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Neves, V., H. M. Coley, J. McFadden, and S. R. P. Silva. "Uptake, Intracellular Localization and Biodistribution of Carbon Nanotubes." In Carbon Nanotubes for Biomedical Applications. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-14802-6_9.

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Berg, T., G. Kindberg, T. Ford, and R. Blomhoff. "Intracellular Degradation of Asialoglycoproteins in Rat Hepatocytes Studied by Fractionation in Nycodenz Gradients." In Receptor-Mediated Uptake in the Liver. Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-70956-2_30.

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Liu, Li, and Chien Ho. "A New Approach to Decrease the RES Uptake of Nanodrugs by Pre-administration with Intralipid® Resulting in a Reduction of Toxic Side Effects." In Intracellular Delivery III. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-43525-1_5.

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Gachanja, Naomi N., David A. Dorward, Adriano G. Rossi, and Christopher D. Lucas. "Assays of Eosinophil Apoptosis and Phagocytic Uptake." In Methods in Molecular Biology. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1095-4_10.

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AbstractEosinophil apoptosis (programmed cell death) plays an important role in several inflammatory and allergic conditions. Apoptosis triggers various mechanisms including activation of cysteine-aspartic proteases (caspases) and is characterized by morphological and biochemical changes. These include cellular condensation, nuclear fragmentation, increased mitochondrial permeability with loss of membrane potential, and exposure of phosphatidylserine on the cell membrane. A greater understanding of apoptotic mechanisms, subsequent phagocytosis (efferocytosis), and regulation of these processes
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Foroozandeh, Parisa, Siti Asmaa Mat Jusoh, and Shaharum Shamsuddin. "Passive Drug Delivery, Mechanisms of Uptake, and Intracellular Trafficking." In Organelle and Molecular Targeting. CRC Press, 2021. http://dx.doi.org/10.1201/9781003092773-5.

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Larsen, Erik Hviid, and Jens Nørkær Sørensen. "Stationary and Nonstationary Ion and Water Flux Interactions in Kidney Proximal Tubule: Mathematical Analysis of Isosmotic Transport by a Minimalistic Model." In Reviews of Physiology, Biochemistry and Pharmacology. Springer International Publishing, 2019. http://dx.doi.org/10.1007/112_2019_16.

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AbstractOur mathematical model of epithelial transport (Larsen et al. Acta Physiol. 195:171–186, 2009) is extended by equations for currents and conductance of apical SGLT2. With independent variables of the physiological parameter space, the model reproduces intracellular solute concentrations, ion and water fluxes, and electrophysiology of proximal convoluted tubule. The following were shown: Water flux is given by active Na+ flux into lateral spaces, while osmolarity of absorbed fluid depends on osmotic permeability of apical membranes. Following aquaporin “knock-out,” water uptake is not r
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Conference papers on the topic "Intracellular uptake"

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Panariti, A., B. Lettiero, I. Morjan, et al. "Uptake And Intracellular Distribution Of Functionalized Iron Oxide Nanoparticles." In BONSAI PROJECT SYMPOSIUM: BREAKTHROUGHS IN NANOPARTICLES FOR BIO-IMAGING. AIP, 2010. http://dx.doi.org/10.1063/1.3505057.

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Miller, Gerald G., Kevin Brown, Ronald B. Moore, et al. "Intracellular uptake kinetics of hypocrellin photosensitizers for photodynamic therapy." In Fifth International Photodynamic Association Biennial Meeting, edited by Denis A. Cortese. SPIE, 1994. http://dx.doi.org/10.1117/12.203432.

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Ferrati, Silvia, Rita E. Serda, Andrew Bean, and Mauro Ferrari. "Intracellular Trafficking of Nano-Carriers." In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13303.

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A multistage delivery system based on biodegradable mesoporous silicon particles loaded with one or multiple second stage nano-particles is likely to be useful for drug delivery. Upon intravenous injection the silicon nano-carriers will travel through the blood stream and migrate to the vessel wall. Vascular endothelial cells have been shown to be promising candidates for drug delivery as they represent both an anchor point and target.[1] It has been shown that human endothelial cells can act as nonprofessional phagocytes internalizing our silicon micron-sized nano-carriers.[2] The complete un
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Zhang, Wujie, Jianhua Rong, Qian Wang, and Xiaoming He. "Synthesis, Cellular Uptake, and Cytotoxicity of a Thermally Responsive Nanocapsule." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206872.

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Recently, polymeric nanoparticles have attracted tremendous interests as a useful tool to encapsulate therapeutic drugs, genes, and proteins for their controlled and sustained delivery. Among them, polymeric hydrogel nanoparticles with thermal and/or pH responsiveness have attracted particular attention [1]. Trehalose, a non-reducing disaccharide of glucose, has been demonstrated to be a potent, nontoxic bioprotectant for stabilizing lipids, proteins, viruses, and blood cells at cryogenic and particularly, ambient temperatures (i.e., cryo and lyopreservation) [2]. However, intracellular delive
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Brandenberger, C., C. Muehlfeld, AG Lenz, et al. "Preferential Intracellular Localisation of Nanoparticles after Uptake by Pulmonary Epithelial Cells." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a5247.

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Gregas, Molly K., Fei Yan, Jonathan Scaffidi, et al. "Tracking SERS-active nanoprobe intracellular uptake for chemical and biological sensing." In Optics East 2007, edited by Tuan Vo-Dinh, Robert A. Lieberman, and Günter Gauglitz. SPIE, 2007. http://dx.doi.org/10.1117/12.758287.

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Bakhit, C., D. Lewis, R. Billings, and B. Malfroy. "CELLULAR CATABOLISM OF RECOMBINANT TISSUE-TYPE PLASMINOGEN ACTIVATOR: IDENTIFICATION AND CHARACTERIZATION OF A NOVEL HIGH AFFINITY UPTAKE SYSTEM ON RAT HEPATOCYTES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644400.

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The uptake, internalization and intracellular degradation of 125I-labeled rt-PA (125I-rt-PA) by isolated rat hepatocytes was investigated. Incubation at 37°C resulted in internalization of 125I-rt-PA, followed by the appearance of labeled trichloroacetic acid-soluble (TCA) material in the inclubation media due to degradation of rt-PA. Degradation of rt-PA was inhibited by the presence of NH4Cl (10mM) or chloroquine (ImM) (lysosoma tropic agents) in the incubation media. This suggests that rt-PA degradation occurs intracellularly, perhaps within the lysosomes. 125I-rt-PA was taken up by rat hep
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Rong, Ning, Yan Wang, Hao Zhou, Zhenzhen Fan, and Ruming Liu. "Dynamics and Mechnisms of Ultrasound and Microbubble Mediated Intracellular Plasmid DNA Uptake." In 2018 IEEE International Ultrasonics Symposium (IUS). IEEE, 2018. http://dx.doi.org/10.1109/ultsym.2018.8579876.

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Wang, Kexin, Xiang Sang, Shuanghuang Xiao, et al. "Interaction of gold nanorods with ovarian cells: toxicity, uptake and intracellular distribution." In Eleventh International Conference on Information Optics and Photonics (CIOP 2019), edited by Hannan Wang. SPIE, 2019. http://dx.doi.org/10.1117/12.2548784.

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Levy-Toledano, S., J. Enouf, M. Lebret, R. Bredoux, and J. P. Caen. "ABNORMAL CALCIUM TRANSPORT INTO MICROSOMES OF GRAY PLATELET SYNDROME." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644747.

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Gray platelets initially described as lacking α granules also show thrombin-induced aggregation and release lower than normal. One of the possible explanation is a modified intracellular Ca2+ concentration which is involved in platelet activation. We then decided to investigate the relationship between the morphological abnormality and a possible regulation of platelet Ca2+ concentration.We isolated a platelet membrane fraction (100,000 g) enriched in intracellular membranes which actively sequesters Ca2+. This Ca2+ uptake was mediated by a characterized (Ca2+ + Mg2+) ATPase.The isolated membr
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Reports on the topic "Intracellular uptake"

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Masinde, Lwandiko. The Dynamics of Intracellular Uptake of Surface Modified Poly (d, L-Lactide-co-Glycolide) Nanoparticles in Breast Cancer Cells (Rev). Defense Technical Information Center, 2004. http://dx.doi.org/10.21236/ada595766.

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Granot, David, Richard Amasino, and Avner Silber. Mutual effects of hexose phosphorylation enzymes and phosphorous on plant development. United States Department of Agriculture, 2006. http://dx.doi.org/10.32747/2006.7587223.bard.

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Research objectives 1) Analyze the combined effects of hexose phosphorylation and P level in tomato and Arabidopsis plants 2) Analyze the combined effects of hexose phosphorylation and P level in pho1 and pho2 Arabidopsis mutants 3) Clone and analyze the PHO2 gene 4) Select Arabidopsis mutants resistant to high and low P 5) Analyze the Arabidopsis mutants and clone the corresponding genes 6) Survey wild tomato species for growth characteristics at various P levels Background to the topic Hexose phosphorylating enzymes, the first enzymes of sugar metabolism, regulate key processes in plants suc
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99mTc SPECT-CT, Consensus QIBA Profile. Chair Yuni Dewaraja and Robert Miyaoka. Radiological Society of North America (RSNA)/Quantitative Imaging Biomarkers Alliance (QIBA), 2019. https://doi.org/10.1148/qiba/20191021.

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The quantification of 99mTc labeled biomarkers can add unique value in many different settings, ranging from clinical trials of investigation new drugs to the treatment of individual patients with marketed therapeutics. For example, goals of precision medicine include using companion radiopharmaceutical diagnostics as just-in-time, predictive biomarkers for selecting patients to receive targeted treatments, customizing doses of internally administered radiotherapeutics, and assessing responses to treatment. This Profile describes quantitative outcome measures that represent proxies of target c
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