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Journal articles on the topic 'Iron absorption'

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1

TURNBULL, ADAM, FRANS CLETON, CLEMENT A. FINCH, LEE THOMPSON, and JOAN MARTIN. "IRON ABSORPTION. IV. THE ABSORPTION OF HEMOGLOBIN IRON." Nutrition Reviews 47, no. 2 (2009): 51–53. http://dx.doi.org/10.1111/j.1753-4887.1989.tb02786.x.

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2

Fuqua, Brie K., Christopher D. Vulpe, and Gregory J. Anderson. "Intestinal iron absorption." Journal of Trace Elements in Medicine and Biology 26, no. 2-3 (2012): 115–19. http://dx.doi.org/10.1016/j.jtemb.2012.03.015.

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3

Beard, John L., Laura E. Murray-Kolb, Jere D. Haas, and Frank Lawrence. "Iron Absorption Prediction Equations Lack Agreement and Underestimate Iron Absorption." Journal of Nutrition 137, no. 7 (2007): 1741–46. http://dx.doi.org/10.1093/jn/137.7.1741.

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4

Garry, Philip J. "Iron stores related to iron absorption." American Journal of Clinical Nutrition 66, no. 6 (1997): 1483–84. http://dx.doi.org/10.1093/ajcn/66.6.1483a.

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5

Roughead, Zamzam K., and Janet R. Hunt. "Adaptation in iron absorption: iron supplementation reduces nonheme-iron but not heme-iron absorption from food." American Journal of Clinical Nutrition 72, no. 4 (2000): 982–89. http://dx.doi.org/10.1093/ajcn/72.4.982.

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6

Fleming, Robert E., and Robert S. Britton. "Iron Imports. VI. HFE and regulation of intestinal iron absorption." American Journal of Physiology-Gastrointestinal and Liver Physiology 290, no. 4 (2006): G590—G594. http://dx.doi.org/10.1152/ajpgi.00486.2005.

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The majority of clinical cases of iron overload is caused by mutations in the HFE gene. However, the role that HFE plays in the physiology of intestinal iron absorption remains enigmatic. Two major models have been proposed: 1) HFE exerts its effects on iron homeostasis indirectly, by modulating the expression of hepcidin; and 2) HFE exerts its effects directly, by changing the iron status (and therefore the iron absorptive activity) of intestinal enterocytes. The first model places the primary role of HFE in the liver (hepatocytes and/or Kupffer cells). The second model places the primary rol
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7

Li, Xiaofei, Lingyan Zhang, Liyang Zhang, Lin Lu, and Xugang Luo. "Effect of iron source on iron absorption by in situ ligated intestinal loops of broilers." Animal Production Science 57, no. 2 (2017): 308. http://dx.doi.org/10.1071/an15531.

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Two experiments were conducted to investigate the effect of iron (Fe) source on Fe absorption by in situ ligated intestinal loops of broilers. In Experiment 1, in situ ligated intestinal loops from Fe-deficient chicks (29 days old) were perfused with solutions containing 0.45 mmol Fe/L from FeSO4 (FeSO4·7H2O), Fe-Gly chelate, Fe-Met chelate, one of three Fe-amino acid or protein complexes with weak, moderate or extremely strong complex strength (Fe-Met W, Fe-Pro M, or Fe-Pro ES), or the mixtures of FeSO4 with either Gly or Met (Fe + Gly or Fe + Met), respectively, up to 30 min. In Experiment 2
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8

Barrett, Jon F. R., Paul G. Whittaker, John D. Fenwick, John G. Williams, and Tom Lind. "Comparison of Stable Isotopes and Radioisotopes in the Measurement of Iron Absorption in Healthy Women." Clinical Science 87, no. 1 (1994): 91–95. http://dx.doi.org/10.1042/cs0870091.

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1. Stable isotope methods are being used to investigate the absorption of dietary iron. In order to be certain that this new methodology is accurate, we have compared results obtained using stable isotopes and inductively coupled plasma mass spectrometry with those determined using a radioisotope and whole body counting. 2. The stable isotope 54Fe (2.8 mg) was given to 10 healthy non-pregnant women. Six women received the isotope in aqueous form, and four took it with a meat meal. The 54Fe served as a carrier for 10 ng of the radioisotope 59Fe. An ampoule (200 μg) of the isotope 57Fe or 58Fe w
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9

Dilantika, Charisma. "Iron Absorption and its Influencing Factors to Prevent Iron Deficiency." Journal of Indonesian Specialized Nutrition 1, no. 1 (2023): 10–21. http://dx.doi.org/10.46799/jisn.v1i1.2.

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Iron is an important nutrient, required to support tissue oxygen delivery, cell growth and differentiation regulation, and energy metabolism. Body iron levels are mainly controlled by regulation of iron absorption in duodenum and proximal jejunum, allowing absorption to be accurately matched to unregulated losses. Since iron bioavailability often reduced, dietary iron absorption is controlled by cellular and systemic factors to ensure that overall body iron levels are maintained at adequate levels. A better understanding of the mechanism for iron absorption and factors influencing its absorpti
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10

Ajioka, Richard S., Ivana De Domenico, and James P. Kushner. "Hepcidin-Independent Regulation of Dietary Iron Absorption." Blood 112, no. 11 (2008): 3853. http://dx.doi.org/10.1182/blood.v112.11.3853.3853.

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Abstract Iron homeostasis in mammals is maintained at the level of iron absorption by the gut. Hepcidin plays a central role in homeostasis by binding to ferroportin and regulating cellular iron export. We found that mice weaned onto diets ranging from 35–350 mg Fe/kg for a period of 4 wk did not change body iron levels as measured by organ iron content and hematological parameters. Direct measure of absorption of 59Fe administered by gavage revealed an inverse correlation between dietary iron content and absorption. Gavage experiments were done following a 4h fast when the stomach and proxima
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11

Blachier, François, Pierre Vaugelade, Véronique Robert, et al. "Comparative capacities of the pig colon and duodenum for luminal iron absorption." Canadian Journal of Physiology and Pharmacology 85, no. 2 (2007): 185–92. http://dx.doi.org/10.1139/y07-007.

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Iron deficiency is the most common human nutritional disorder in the world. Iron absorptive capacity of the small intestine is known to be much limited and therefore large quantities of iron salts must be used to treat iron deficiency. As a result, significant amounts of iron may reach the large intestine. This study compared the capacities of the small and large intestine to transfer luminal iron to the venous blood in relationship with the expression in epithelial cells of proteins involved in iron absorption using a pig model. Intracaecal injection of iron sulphate corresponding with 2.5 an
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12

Bries, Amanda E., Richard F. Hurrell, and Manju B. Reddy. "Iron Absorption from Bouillon Fortified with Iron-Enriched Aspergillus oryzae Is Higher Than That Fortified with Ferric Pyrophosphate in Young Women." Journal of Nutrition 150, no. 5 (2020): 1109–15. http://dx.doi.org/10.1093/jn/nxaa035.

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ABSTRACT Background Bouillon cubes are a potential vehicle for iron fortification. They are currently fortified with ferric pyrophosphate (FePP), which is known to be poorly absorbed. The objective of this study was to assess the iron absorption of Aspergillus oryzae grown in FePP (ASP-p) and compare it with FePP and ferrous sulfate (FeSO4)–fortified bouillon cubes. Methods In 2 single-blinded, crossover studies, healthy women with serum ferritin concentrations <40 μg/L were randomly assigned to consume a rice-vegetable meal with iron-fortified chicken bouillon. Subjects in study I (n =
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13

Lynch, SR, BS Skikne, and JD Cook. "Food iron absorption in idiopathic hemochromatosis." Blood 74, no. 6 (1989): 2187–93. http://dx.doi.org/10.1182/blood.v74.6.2187.2187.

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Abstract The relationship between iron status and food iron absorption was evaluated in 75 normal volunteers, 15 patients with idiopathic hemochromatosis, and 22 heterozygotes by using double extrinsic radioiron tags to label independently the nonheme and heme iron components of a hamburger meal. In normal subjects, absorption from each of these pools was inversely correlated with storage iron, as measured by the serum ferritin concentration. In patients with hemochromatosis, absorption of both forms of iron was far greater than would be predicted from the relationship between absorption and s
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14

Lynch, SR, BS Skikne, and JD Cook. "Food iron absorption in idiopathic hemochromatosis." Blood 74, no. 6 (1989): 2187–93. http://dx.doi.org/10.1182/blood.v74.6.2187.bloodjournal7462187.

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The relationship between iron status and food iron absorption was evaluated in 75 normal volunteers, 15 patients with idiopathic hemochromatosis, and 22 heterozygotes by using double extrinsic radioiron tags to label independently the nonheme and heme iron components of a hamburger meal. In normal subjects, absorption from each of these pools was inversely correlated with storage iron, as measured by the serum ferritin concentration. In patients with hemochromatosis, absorption of both forms of iron was far greater than would be predicted from the relationship between absorption and serum ferr
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15

Spasic, Maja Vujic, Judit Kiss, Thomas Herrmann, et al. "Physiologic systemic iron metabolism in mice deficient for duodenal Hfe." Blood 109, no. 10 (2007): 4511–17. http://dx.doi.org/10.1182/blood-2006-07-036186.

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Abstract Mutations in the Hfe gene result in hereditary hemochromatosis (HH), a disorder characterized by increased duodenal iron absorption and tissue iron overload. Identification of a direct interaction between Hfe and transferrin receptor 1 in duodenal cells led to the hypothesis that the lack of functional Hfe in the duodenum affects TfR1-mediated serosal uptake of iron and misprogramming of the iron absorptive cells. Contrasting this view, Hfe deficiency causes inappropriately low expression of the hepatic iron hormone hepcidin, which causes increased duodenal iron absorption. We specifi
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16

Magnusson, B., E. Bjorn-Rasmussen, L. Hallberg, and L. Rossander. "Iron Absorption in Relation to Iron Status." Scandinavian Journal of Haematology 27, no. 3 (2009): 201–8. http://dx.doi.org/10.1111/j.1600-0609.1981.tb00473.x.

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17

BOTHWELL, T. H., R. D. BAYNES, B. J. MACFARLANE, and A. P. MACPHAIL. "Nutritional iron requirements and food iron absorption." Journal of Internal Medicine 226, no. 5 (1989): 357–65. http://dx.doi.org/10.1111/j.1365-2796.1989.tb01409.x.

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18

Huebers, H. A., E. Csiba, B. Josephson, and C. A. Finch. "Iron absorption in the iron-deficient rat." Blut 60, no. 6 (1990): 345–51. http://dx.doi.org/10.1007/bf01737850.

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19

Leong, Weng-In, Christopher L. Bowlus, Jonas Tallkvist, and Bo Lönnerdal. "DMT1 and FPN1 expression during infancy: developmental regulation of iron absorption." American Journal of Physiology-Gastrointestinal and Liver Physiology 285, no. 6 (2003): G1153—G1161. http://dx.doi.org/10.1152/ajpgi.00107.2003.

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Two iron transporters, divalent metal transporter1 (DMT1) and ferroportin1 (FPN1) have been identified; however, their role during infancy is unknown. We investigated DMT1, FPN1, ferritin, and transferrin receptor expression, iron absorption and tissue iron in iron-deficient rat pups, iron-deficient rat pups given iron supplements, and controls during early ( day 10) and late infancy ( day 20). With iron deficiency, DMT1 was unchanged and FPN1 was decreased (-80%) at day 10. Body iron uptake, mucosal iron retention, and total iron absorption were unchanged. At day 20, DMT1 increased fourfold a
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20

O??Neil-Cutting, Mary A., and William H. Crosby. "Antacids and Iron Absorption." Nurse Practitioner 11, no. 8 (1986): 70. http://dx.doi.org/10.1097/00006205-198608000-00015.

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21

Anderson, Gregory J., David M. Frazer, and Gordon D. McLaren. "Iron absorption and metabolism." Current Opinion in Gastroenterology 25, no. 2 (2009): 129–35. http://dx.doi.org/10.1097/mog.0b013e32831ef1f7.

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22

ANDERSON, GREGORY J. "Control of iron absorption." Journal of Gastroenterology and Hepatology 11, no. 11 (1996): 1030–32. http://dx.doi.org/10.1111/j.1440-1746.1996.tb00029.x.

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23

Sörensen, Einar Wolff. "Studies on Iron Absorption." Acta Medica Scandinavica 180, no. 2 (2009): 241–44. http://dx.doi.org/10.1111/j.0954-6820.1966.tb02831.x.

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24

Sörensen, Einar Wolff. "Studies on Iron Absorption." Acta Medica Scandinavica 181, no. 6 (2009): 707–16. http://dx.doi.org/10.1111/j.0954-6820.1967.tb07989.x.

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25

Sörensen, Einar Wolff. "Studies on Iron Absorption." Acta Medica Scandinavica 181, no. 6 (2009): 739–46. http://dx.doi.org/10.1111/j.0954-6820.1967.tb07995.x.

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26

Sotos, John G. "Beeturia and iron absorption." Lancet 354, no. 9183 (1999): 1032. http://dx.doi.org/10.1016/s0140-6736(05)76638-1.

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27

Hauge, Bodil Nexmand. "The Iron Absorption Test." Acta Medica Scandinavica 168, no. 2 (2009): 109–16. http://dx.doi.org/10.1111/j.0954-6820.1960.tb06651.x.

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28

SØRENSEN, EINAR WOLFF. "Studies on Iron Absorption." Acta Medica Scandinavica 175, no. 6 (2009): 763–70. http://dx.doi.org/10.1111/j.0954-6820.1964.tb00633.x.

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29

Sørensen, Einar Wolff. "Studies on Iron Absorption." Acta Medica Scandinavica 178, no. 4 (2009): 385–92. http://dx.doi.org/10.1111/j.0954-6820.1965.tb04283.x.

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30

Conrad, Marcel E., Jay N. Umbreit, and Elizabeth G. Moore. "Iron Absorption and Transport." American Journal of the Medical Sciences 318, no. 4 (1999): 213–29. http://dx.doi.org/10.1016/s0002-9629(15)40626-3.

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31

Andrews, Nancy C. "Iron metabolism and absorption." Reviews in Clinical and Experimental Hematology 4, no. 4 (2000): 283–301. http://dx.doi.org/10.1046/j.1468-0734.2000.00021.x.

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32

CONRAD, MARCEL E., JAY N. UMBREIT, and ELIZABETH G. MOORE. "Iron Absorption and Transport." American Journal of the Medical Sciences 318, no. 4 (1999): 213. http://dx.doi.org/10.1097/00000441-199910000-00002.

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33

Conrad, Marcel E., and Jay N. Umbreit. "Pathways of Iron Absorption." Blood Cells, Molecules, and Diseases 29, no. 3 (2002): 336–55. http://dx.doi.org/10.1006/bcmd.2002.0564.

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34

Hallberg, Leif, and Lena Hulthén. "Perspectives on Iron Absorption." Blood Cells, Molecules, and Diseases 29, no. 3 (2002): 562–73. http://dx.doi.org/10.1006/bcmd.2002.0603.

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35

Pramudita, Saphira, Ulfa Yasmin, Sulistiawati Sulistiawati, and Novita Idayani. "THE RELATIONSHIP BETWEEN pH VALUE OF IRON SUPPLEMENT WITH THE ABSORPTION OF IRON IONS IN DECIDUOUS TEETH (AN IN VITRO STUDY)." Dentino: Jurnal Kedokteran Gigi 10, no. 1 (2025): 104. https://doi.org/10.20527/dentino.v10i1.22213.

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Background: Iron deficiency anemia is a prior health issue that often occurs in school-aged children. Iron substances have a critical role in neurological growth, so it is necessary to give iron supplements as therapy. Iron supplements can affect deciduous teeth. Aims: To measure the pH and absorption value of iron supplements in deciduous teeth and determine the relationship between pH value of iron supplements with the absorption of iron ions in deciduous teeth. Material and Methods: This study is an experimental in vitro- study. Sample groups used iron supplements (Ferriz, Sangobion Kids, F
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36

Correnti, Margherita, Elena Gammella, Gaetano Cairo, and Stefania Recalcati. "Iron Absorption: Molecular and Pathophysiological Aspects." Metabolites 14, no. 4 (2024): 228. http://dx.doi.org/10.3390/metabo14040228.

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Iron is an essential nutrient for growth among all branches of life, but while iron is among the most common elements, bioavailable iron is a relatively scarce nutrient. Since iron is fundamental for several biological processes, iron deficiency can be deleterious. On the other hand, excess iron may lead to cell and tissue damage. Consequently, iron balance is strictly regulated. As iron excretion is not physiologically controlled, systemic iron homeostasis is maintained at the level of absorption, which is mainly influenced by the amount of iron stores and the level of erythropoietic activity
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37

Szymlek-Gay, Ewa A., Magnus Domellöf, Olle Hernell, et al. "Mode of oral iron administration and the amount of iron habitually consumed do not affect iron absorption, systemic iron utilisation or zinc absorption in iron-sufficient infants: a randomised trial." British Journal of Nutrition 116, no. 6 (2016): 1046–60. http://dx.doi.org/10.1017/s0007114516003032.

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AbstractDifferent metabolic pathways of supplemental and fortification Fe, or inhibition of Zn absorption by Fe, may explain adverse effects of supplemental Fe in Fe-sufficient infants. We determined whether the mode of oral Fe administration or the amount habitually consumed affects Fe absorption and systemic Fe utilisation in infants, and assessed the effects of these interventions on Zn absorption, Fe and Zn status, and growth. Fe-sufficient 6-month-old infants (n72) were randomly assigned to receive 6·6 mg Fe/d from a high-Fe formula, 1·3 mg Fe/d from a low-Fe formula or 6·6 mg Fe/d from F
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38

Chang, Suying, Zhenwu Huang, Yuxia Ma, et al. "Mixture of Ferric Sodium Ethylenediaminetetraacetate (NaFeEDTA) and Ferrous Sulfate: An Effective Iron Fortificant for Complementary Foods for Young Chinese Children." Food and Nutrition Bulletin 33, no. 2 (2012): 111–16. http://dx.doi.org/10.1177/156482651203300204.

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Background Ferric sodium ethylenediaminetetraacetate (NaFeEDTA) enhances iron absorption in the presence of phytate. However, the amount of NaFeEDTA that would have to be added to a complementary food to provide the necessary intake of iron for an infant or young child if NaFeEDTA were the sole iron fortificant exceeds the Acceptable Daily Intake (ADI) of EDTA for this age group. EDTA increases iron absorption at a molar ratio EDTA:iron of less than 1:1. Objective To determine whether iron absorption is enhanced with a mixture of ferrous sulfate (FeSO4) and NaFeEDTA. Methods Two studies with a
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39

Thomas, Carla, and Phillip S. Oates. "Copper deficiency increases iron absorption in the rat." American Journal of Physiology-Gastrointestinal and Liver Physiology 285, no. 5 (2003): G789—G795. http://dx.doi.org/10.1152/ajpgi.00509.2002.

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Release of iron from enterocytes and hepatocytes is thought to require the copper-dependent ferroxidase activity of hephaestin (Hp) and ceruloplasmin (Cp), respectively. In swine, copper deficiency (CD) impairs iron absorption, but whether this occurs in rats is unclear. By feeding a diet deficient in copper, CD was produced, as evidenced by the loss of copper-dependent plasma ferroxidase I activity, and in enterocytes, CD reduced copper levels and copper-dependent oxidase activity. Hematocrit was reduced, and liver iron was doubled. CD reduced duodenal mucosal iron and ferritin, whereas CD in
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40

Follett, Jennifer R., Yasushi A. Suzuki, and Bo Lönnerdal. "High specific activity heme-Fe and its application for studying heme-Fe metabolism in Caco-2 cell monolayers." American Journal of Physiology-Gastrointestinal and Liver Physiology 283, no. 5 (2002): G1125—G1131. http://dx.doi.org/10.1152/ajpgi.00443.2001.

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Heme-Fe is an important source of dietary iron in humans. Caco-2 cells have been used extensively to study human iron absorption with an emphasis on factors affecting nonheme iron absorption. Therefore, we examined several factors known to affect heme iron absorption. Cells grown in bicameral chambers were incubated with high specific activity [59Fe]heme alone or with 1% globin, BSA, or fatty acid-free BSA (BSA-FA) to examine the effect of protein source on absorption. Heme iron absorption was enhanced by globin and inhibited by BSA and BSA-FA. Absorption of heme iron in cells pretreated for 7
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41

Santos, Manuela, Hans Clevers, Maria de Sousa та J. J. M. Marx. "Adaptive Response of Iron Absorption to Anemia, Increased Erythropoiesis, Iron Deficiency, and Iron Loading in β2-Microglobulin Knockout Mice". Blood 91, № 8 (1998): 3059–65. http://dx.doi.org/10.1182/blood.v91.8.3059.3059_3059_3065.

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Recently, a novel gene of the major histocompatibility complex (MHC) class I family, HFE (HLA-H), has been found to be mutated in a large proportion of hereditary hemochromatosis (HH) patients. Further support for a causative role of HFE in this disease comes from the observation that β2-microglobulin knockout (β2m−/−) mice, that fail to express MHC class I products, develop iron overload. We have now used this animal model of HH to examine the capacity to adapt iron absorption in response to altered iron metabolism in the absence of β2m-dependent molecule(s). Mucosal uptake, mucosal transfer
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42

LINAKIS, JAMES G., PETER G. LACOUTURE, and ALAN WOOLF. "Iron absorption from chewable vitamins with iron versus iron tablets." Pediatric Emergency Care 8, no. 6 (1992): 321–24. http://dx.doi.org/10.1097/00006565-199212000-00003.

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43

Gallahan, Samantha, Stephanie Brower, Hannah Wapshott-Stehli, Joelle Santos, and Thao T. B. Ho. "A Systematic Review of Isotopically Measured Iron Absorption in Infants and Children Under 2 Years." Nutrients 16, no. 22 (2024): 3834. http://dx.doi.org/10.3390/nu16223834.

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Background: Iron is an essential element for critical biological functions, with iron deficiency negatively affecting growth and brain development and iron excess associated with adverse effects. The goal of this review is to provide a comprehensive assessment of up-to-date evidence on iron absorption measured isotopically in children, preterm infants, and full-term infants, up to 24 months of age. Methods: Search databases included Pubmed, Cochrane, Web of Science, and Scopus from a date range of 1 January 1953 to 22 July 2024. The included articles were experimental studies with iron absorpt
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44

Hoppe, Michael, Gunilla Önning, Anna Berggren, and Lena Hulthén. "Probiotic strainLactobacillus plantarum299v increases iron absorption from an iron-supplemented fruit drink: a double-isotope cross-over single-blind study in women of reproductive age." British Journal of Nutrition 114, no. 8 (2015): 1195–202. http://dx.doi.org/10.1017/s000711451500241x.

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Iron deficiency is common, especially among young women. Adding probiotics to foods could be one way to increase iron absorption. The aim of this study was to test the hypothesis that non-haem iron absorption from a fruit drink is improved by addingLactobacillus plantarum299v (Lp299v). Iron absorption was studied in healthy women of reproductive age using a single-blind cross-over design in two trials applying the double-isotope (55Fe and59Fe) technique. In Trial 1, iron absorption from a fruit drink containing 109colony-forming units (CFU) Lp299v was compared with that from a control drink wi
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45

Wang, Jun, Gabor Radics, Michael Whelehan, et al. "Novel Iron-Whey Protein Microspheres Protect Gut Epithelial Cells from Iron-Related Oxidative Stress and Damage and Improve Iron Absorption in Fasting Adults." Acta Haematologica 138, no. 4 (2017): 223–32. http://dx.doi.org/10.1159/000480632.

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Background: Iron food fortification and oral iron formulations are frequently limited by poor absorption, resulting in the widespread use of high-dose oral iron, which is poorly tolerated. Methods: We evaluated novel iron-denatured whey protein (Iron-WP) microspheres on reactive oxygen species (ROS) and viability in gut epithelial (HT29) cells. We compared iron absorption from Iron-WP versus equimolar-dose (25 mg elemental iron) ferrous sulphate (FeSO4) in a prospective, randomised, cross-over study in fasting volunteers (n = 21 per group) dependent on relative iron depletion (a ferritin level
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46

Ekenved, Gunnar. "ABSORPTION FROM DIFFERENT TYPES OF IRON TABLETS - CORRELATION BETWEEN SERUM IRON INCREASE AND TOTAL ABSORPTION OF IRON." Scandinavian Journal of Haematology 17, S28 (2009): 51–63. http://dx.doi.org/10.1111/j.1600-0609.1976.tb00348.x.

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47

Lynch. "Influence of Infection/Inflammation, Thalassemia and Nutritional Status on Iron Absorption." International Journal for Vitamin and Nutrition Research 77, no. 3 (2007): 217–23. http://dx.doi.org/10.1024/0300-9831.77.3.217.

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Iron balance in human beings is maintained by the control of absorption. Recent observations have demonstrated that a peptide hormone, hepcidin, is the principal regulator of iron homeostasis. It is produced in the liver in response to increasing iron stores. It is also induced by interleukin-6 (IL-6) in infectious and inflammatory diseases. Hepcidin restricts both iron absorption and iron release from stores. Disorders that affect the duodenum or stomach directly, particularly gluten enteropathy and H. pylori infections, also impair iron absorption by damaging enterocytes or reducing gastric
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48

Ajioka, Richard S., Joanne E. Levy, Nancy C. Andrews, and James P. Kushner. "Regulation of iron absorption in Hfe mutant mice." Blood 100, no. 4 (2002): 1465–69. http://dx.doi.org/10.1182/blood-2001-11-0037.

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Hereditary hemochromatosis is most commonly caused by homozygosity for a point mutation (C282Y) in the human hemochromatosis gene (HFE). The mechanism by which HFEregulates iron absorption is not known, but the C282Y mutation results in loss of cell surface expression of the human hemachromatosis protein (HFE) and hyperabsorption of iron by the duodenal enterocyte. Mice homozygous for a deletion in the mouse hemochromatosis gene (Hfe) or a mutation equivalent to that seen in human hereditary hemochromatosis (C282Y) were compared with wild-type animals for their ability to regulate iron absorpt
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Magnusson, Bengt, Lennart Sölvell, Bertil Arvidsson, and Christer Siösteen. "Iron Absorption during Iron Supplementation in Blood Donors." Scandinavian Journal of Haematology 14, no. 5 (2009): 337–46. http://dx.doi.org/10.1111/j.1600-0609.1975.tb02705.x.

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50

KAWAKAMI, Hiroshi, Makiko HIRATSUKA, and Shun''ichi DOSAKO. "Effects of iron-saturated lactoferrin on iron absorption." Agricultural and Biological Chemistry 52, no. 4 (1988): 903–8. http://dx.doi.org/10.1271/bbb1961.52.903.

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